TY  - JOUR
AU  - Miladinov, Marko
AU  - Rosić, Jovana
AU  - Erić, Katarina
AU  - Guzonjić, Azra
AU  - Jelenković, Jelenko
AU  - Bogavac-Stanojević, Nataša
AU  - Dimitrijević, Ivan
AU  - Kotur-Stevuljević, Jelena
AU  - Barišić, Goran
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5204
AB  - The Schlafen 11 (SLFN11) protein has recently emerged as pivotal in DNA damage conditions, with predictive potential for tumor response to cytotoxic chemotherapies. Recent discoveries also showed that the programmed death ligand 1 (PD-L1) protein can be found on malignant cells, providing an immune evasion mechanism exploited by different tumors. Additionally, excessive generation of free radicals, redox imbalance, and consequential DNA damage can affect intestinal cell homeostasis and lead to neoplastic transformation. Therefore, our study aimed to investigate the significance of SLFN11 and PD-L1 proteins and redox status parameters as prognostic biomarkers in CRC patients. This study included a total of 155 CRC patients. SLFN11 and PD-L1 serum levels were measured with ELISA and evaluated based on redox status parameters, sociodemographic and clinical characteristics, and survival. The following redox status parameters were investigated: spectrophotometrically measured superoxide dismutase (SOD), sulfhydryl (SH) groups, advanced oxidation protein products (AOPP), malondialdehyde (MDA), pro-oxidant–antioxidant balance (PAB), and superoxide anion (O2•–). The prooxidative score, antioxidative score, and OXY-SCORE were also calculated. The results showed significantly shorter survival in patients with higher OXY-SCOREs and higher levels of serum SLFN11, while only histopathology-analysis-related factors showed significant prognostic value. OXY-SCORE and SLFN11 levels may harbor prognostic potential in CRC patients.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Analysis of the Prognostic Potential of Schlafen 11, Programmed Death Ligand 1, and Redox Status in Colorectal Cancer Patients
VL  - 24
IS  - 20
DO  - 10.3390/ijms242015083
ER  - 

@article{
author = "Miladinov, Marko and Rosić, Jovana and Erić, Katarina and Guzonjić, Azra and Jelenković, Jelenko and Bogavac-Stanojević, Nataša and Dimitrijević, Ivan and Kotur-Stevuljević, Jelena and Barišić, Goran",
year = "2023",
abstract = "The Schlafen 11 (SLFN11) protein has recently emerged as pivotal in DNA damage conditions, with predictive potential for tumor response to cytotoxic chemotherapies. Recent discoveries also showed that the programmed death ligand 1 (PD-L1) protein can be found on malignant cells, providing an immune evasion mechanism exploited by different tumors. Additionally, excessive generation of free radicals, redox imbalance, and consequential DNA damage can affect intestinal cell homeostasis and lead to neoplastic transformation. Therefore, our study aimed to investigate the significance of SLFN11 and PD-L1 proteins and redox status parameters as prognostic biomarkers in CRC patients. This study included a total of 155 CRC patients. SLFN11 and PD-L1 serum levels were measured with ELISA and evaluated based on redox status parameters, sociodemographic and clinical characteristics, and survival. The following redox status parameters were investigated: spectrophotometrically measured superoxide dismutase (SOD), sulfhydryl (SH) groups, advanced oxidation protein products (AOPP), malondialdehyde (MDA), pro-oxidant–antioxidant balance (PAB), and superoxide anion (O2•–). The prooxidative score, antioxidative score, and OXY-SCORE were also calculated. The results showed significantly shorter survival in patients with higher OXY-SCOREs and higher levels of serum SLFN11, while only histopathology-analysis-related factors showed significant prognostic value. OXY-SCORE and SLFN11 levels may harbor prognostic potential in CRC patients.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Analysis of the Prognostic Potential of Schlafen 11, Programmed Death Ligand 1, and Redox Status in Colorectal Cancer Patients",
volume = "24",
number = "20",
doi = "10.3390/ijms242015083"
}

Miladinov, M., Rosić, J., Erić, K., Guzonjić, A., Jelenković, J., Bogavac-Stanojević, N., Dimitrijević, I., Kotur-Stevuljević, J.,& Barišić, G.. (2023). Analysis of the Prognostic Potential of Schlafen 11, Programmed Death Ligand 1, and Redox Status in Colorectal Cancer Patients. in International Journal of Molecular Sciences
MDPI., 24(20).
https://doi.org/10.3390/ijms242015083

Miladinov M, Rosić J, Erić K, Guzonjić A, Jelenković J, Bogavac-Stanojević N, Dimitrijević I, Kotur-Stevuljević J, Barišić G. Analysis of the Prognostic Potential of Schlafen 11, Programmed Death Ligand 1, and Redox Status in Colorectal Cancer Patients. in International Journal of Molecular Sciences. 2023;24(20).
doi:10.3390/ijms242015083 .

Miladinov, Marko, Rosić, Jovana, Erić, Katarina, Guzonjić, Azra, Jelenković, Jelenko, Bogavac-Stanojević, Nataša, Dimitrijević, Ivan, Kotur-Stevuljević, Jelena, Barišić, Goran, "Analysis of the Prognostic Potential of Schlafen 11, Programmed Death Ligand 1, and Redox Status in Colorectal Cancer Patients" in International Journal of Molecular Sciences, 24, no. 20 (2023),
https://doi.org/10.3390/ijms242015083 . .