TY  - CONF
AU  - Mandinić, Zoran
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Nedeljković, Mirjana
AU  - Carević, Momir
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/986
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Fluoride levels in hair samples - Biomarker of exposure
VL  - 172
IS  - Supplement
SP  - S119
EP  - S119
DO  - 10.1016/j.toxlet.2007.05.316
ER  - 

@conference{
author = "Mandinić, Zoran and Ćurčić, Marijana and Antonijević, Biljana and Nedeljković, Mirjana and Carević, Momir",
year = "2007",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Fluoride levels in hair samples - Biomarker of exposure",
volume = "172",
number = "Supplement",
pages = "S119-S119",
doi = "10.1016/j.toxlet.2007.05.316"
}

Mandinić, Z., Ćurčić, M., Antonijević, B., Nedeljković, M.,& Carević, M.. (2007). Fluoride levels in hair samples - Biomarker of exposure. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 172(Supplement), S119-S119.
https://doi.org/10.1016/j.toxlet.2007.05.316

Mandinić Z, Ćurčić M, Antonijević B, Nedeljković M, Carević M. Fluoride levels in hair samples - Biomarker of exposure. in Toxicology Letters. 2007;172(Supplement):S119-S119.
doi:10.1016/j.toxlet.2007.05.316 .

Mandinić, Zoran, Ćurčić, Marijana, Antonijević, Biljana, Nedeljković, Mirjana, Carević, Momir, "Fluoride levels in hair samples - Biomarker of exposure" in Toxicology Letters, 172, no. Supplement (2007):S119-S119,
https://doi.org/10.1016/j.toxlet.2007.05.316 . .

TY  - JOUR
AU  - Nedeljković, Mirjana
AU  - Antonijević, Biljana
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/569
AB  - Organization of a clinical-toxicological laboratory is presented and characteristics to be met by this type of laboratory are emphasized. In order to fulfill the competent role of a clinical-toxicological laboratory related to diagnosis and treatment of the acutely intoxicated patients, it is necessary to define a program of such laboratory. The analyses included into the scope of work of the laboratory are categorized according to the type of sample needed for the analysis, time requirements as well as sensitivity level of analytical method. The laboratory must be equipped with all the necessary equipment and staffed with adequately trained professionals, in order to enable for the results of analyses to be relevant for both physicians and patients.
AB  - Prikazana je organizacija kliničko-toksikološke laboratorije i istaknute karakteristike koje ovaj tip laboratorije treba da ispunjava. U cilju ostvarivanja kompetentne uloge kliničko-toksikološke laboratorije u dijagnostici i terapiji akutno otrovanih pacijenata, neophodno je definisati program rada laboratorije. Analize koje se nalaze u programu rada laboratorije su kategorizovane prema tipu uzorka koji je potreban za analizu, vremenu koje je potrebno za njihovo izvođenje kao i nivou osetljivosti metode. Laboratorija mora biti opremljena potrebnom opremom sa kvalifikovanom strukturom zaposlenih, tako da su rezultati analiza od značaja za kliničke toksikologe i za pacijente.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Clinical-toxicological laboratory organization
T1  - Organizacija kliničko-toksikološke laboratorije
VL  - 55
IS  - 3
SP  - 266
EP  - 279
UR  - https://hdl.handle.net/21.15107/rcub_farfar_569
ER  - 

@article{
author = "Nedeljković, Mirjana and Antonijević, Biljana",
year = "2005",
abstract = "Organization of a clinical-toxicological laboratory is presented and characteristics to be met by this type of laboratory are emphasized. In order to fulfill the competent role of a clinical-toxicological laboratory related to diagnosis and treatment of the acutely intoxicated patients, it is necessary to define a program of such laboratory. The analyses included into the scope of work of the laboratory are categorized according to the type of sample needed for the analysis, time requirements as well as sensitivity level of analytical method. The laboratory must be equipped with all the necessary equipment and staffed with adequately trained professionals, in order to enable for the results of analyses to be relevant for both physicians and patients., Prikazana je organizacija kliničko-toksikološke laboratorije i istaknute karakteristike koje ovaj tip laboratorije treba da ispunjava. U cilju ostvarivanja kompetentne uloge kliničko-toksikološke laboratorije u dijagnostici i terapiji akutno otrovanih pacijenata, neophodno je definisati program rada laboratorije. Analize koje se nalaze u programu rada laboratorije su kategorizovane prema tipu uzorka koji je potreban za analizu, vremenu koje je potrebno za njihovo izvođenje kao i nivou osetljivosti metode. Laboratorija mora biti opremljena potrebnom opremom sa kvalifikovanom strukturom zaposlenih, tako da su rezultati analiza od značaja za kliničke toksikologe i za pacijente.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Clinical-toxicological laboratory organization, Organizacija kliničko-toksikološke laboratorije",
volume = "55",
number = "3",
pages = "266-279",
url = "https://hdl.handle.net/21.15107/rcub_farfar_569"
}

Nedeljković, M.,& Antonijević, B.. (2005). Clinical-toxicological laboratory organization. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 55(3), 266-279.
https://hdl.handle.net/21.15107/rcub_farfar_569

Nedeljković M, Antonijević B. Clinical-toxicological laboratory organization. in Arhiv za farmaciju. 2005;55(3):266-279.
https://hdl.handle.net/21.15107/rcub_farfar_569 .

Nedeljković, Mirjana, Antonijević, Biljana, "Clinical-toxicological laboratory organization" in Arhiv za farmaciju, 55, no. 3 (2005):266-279,
https://hdl.handle.net/21.15107/rcub_farfar_569 .

TY  - JOUR
AU  - Stefanović, Danka
AU  - Antonijević, Biljana
AU  - Bokonjić, Dubravko
AU  - Stojiljković, Miloš P.
AU  - Milovanović, Zoran A.
AU  - Nedeljković, Mirjana
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/565
AB  - The aim of the present work was to examine potential beneficial role of sodium bicarbonate (3 mmol/kg ip) on protective potency of trimedoxime (10 mg/kg im), obidoxime (10 mg/kg im) and atropine (10 mg/kg im) in rats poisoned with dichlorvos. Special attention was paid to the influence of co-administration of sodium bicarbonate on acid-base status in experimental animals poisoned with dichlorvos (1.3 LD50 sc). Coadministration of sodium bicarbonate significantly increased protective effect of standard antidotes in rats poisoned with dichlorvos. Sodium bicarbonate given along with atropine/oxime produced an increase in blood pH value and correction of acidosis. In conclusion, correlation between protective effect and biochemical outcome was evident when sodium bicarbonate was added to antidotes.
AB  - Cilj rada je bio da se ispita efekat natrijum bikarbonata (3 mmol/kg ip) na zaštitni potencijal trimedoksima (10 mg/kg im), obidoksima (10 mg/kg im) i atropina (10 mg/kg im) u pacova trovanih dihlorvosom. Posebna pažnja je posvećena uticaju kombinacija natrijum bikarbonata i antidota na acido-bazni status eksperimentalnih životinja trovanih dihlorvosom (1.3 LD50 ). Primena kombinacija sa natrijum bikarbonatom zna- čajno je povećala zaštitne efekte standardnih antidota, a došlo je i do porasta vrednosti pH krvi i korekcije acidoze. Takođe, moglo se zaključiti da kada je natrijum bikarbonat dat zajedno sa atropinom/oksimom postoji jasna korelacija između dobijenih zaštitnih efekata i testiranih biohemijskih parametara.
PB  - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2  - Jugoslovenska medicinska biohemija
T1  - Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos
T1  - Uticaj natrijum bikarbonata i standardnih antidota na acido-bazni status pacova trovanih dihlorvosom
VL  - 23
IS  - 2
SP  - 165
EP  - 170
DO  - 10.2298/JMH0402165S
ER  - 

@article{
author = "Stefanović, Danka and Antonijević, Biljana and Bokonjić, Dubravko and Stojiljković, Miloš P. and Milovanović, Zoran A. and Nedeljković, Mirjana",
year = "2004",
abstract = "The aim of the present work was to examine potential beneficial role of sodium bicarbonate (3 mmol/kg ip) on protective potency of trimedoxime (10 mg/kg im), obidoxime (10 mg/kg im) and atropine (10 mg/kg im) in rats poisoned with dichlorvos. Special attention was paid to the influence of co-administration of sodium bicarbonate on acid-base status in experimental animals poisoned with dichlorvos (1.3 LD50 sc). Coadministration of sodium bicarbonate significantly increased protective effect of standard antidotes in rats poisoned with dichlorvos. Sodium bicarbonate given along with atropine/oxime produced an increase in blood pH value and correction of acidosis. In conclusion, correlation between protective effect and biochemical outcome was evident when sodium bicarbonate was added to antidotes., Cilj rada je bio da se ispita efekat natrijum bikarbonata (3 mmol/kg ip) na zaštitni potencijal trimedoksima (10 mg/kg im), obidoksima (10 mg/kg im) i atropina (10 mg/kg im) u pacova trovanih dihlorvosom. Posebna pažnja je posvećena uticaju kombinacija natrijum bikarbonata i antidota na acido-bazni status eksperimentalnih životinja trovanih dihlorvosom (1.3 LD50 ). Primena kombinacija sa natrijum bikarbonatom zna- čajno je povećala zaštitne efekte standardnih antidota, a došlo je i do porasta vrednosti pH krvi i korekcije acidoze. Takođe, moglo se zaključiti da kada je natrijum bikarbonat dat zajedno sa atropinom/oksimom postoji jasna korelacija između dobijenih zaštitnih efekata i testiranih biohemijskih parametara.",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos, Uticaj natrijum bikarbonata i standardnih antidota na acido-bazni status pacova trovanih dihlorvosom",
volume = "23",
number = "2",
pages = "165-170",
doi = "10.2298/JMH0402165S"
}

Stefanović, D., Antonijević, B., Bokonjić, D., Stojiljković, M. P., Milovanović, Z. A.,& Nedeljković, M.. (2004). Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos. in Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 23(2), 165-170.
https://doi.org/10.2298/JMH0402165S

Stefanović D, Antonijević B, Bokonjić D, Stojiljković MP, Milovanović ZA, Nedeljković M. Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos. in Jugoslovenska medicinska biohemija. 2004;23(2):165-170.
doi:10.2298/JMH0402165S .

Stefanović, Danka, Antonijević, Biljana, Bokonjić, Dubravko, Stojiljković, Miloš P., Milovanović, Zoran A., Nedeljković, Mirjana, "Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos" in Jugoslovenska medicinska biohemija, 23, no. 2 (2004):165-170,
https://doi.org/10.2298/JMH0402165S . .

TY  - CONF
AU  - Jovanović, D.
AU  - Ćurčić, Marijana
AU  - Nedeljković, Mirjana
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/386
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Fluoride content in potable water on territory of Vranje
T1  - Sadržaj fluorida u vodi za piće na teritoriji Vranja
VL  - 52
IS  - 4
SP  - 772
EP  - 773
UR  - https://hdl.handle.net/21.15107/rcub_farfar_386
ER  - 

@conference{
author = "Jovanović, D. and Ćurčić, Marijana and Nedeljković, Mirjana",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Fluoride content in potable water on territory of Vranje, Sadržaj fluorida u vodi za piće na teritoriji Vranja",
volume = "52",
number = "4",
pages = "772-773",
url = "https://hdl.handle.net/21.15107/rcub_farfar_386"
}

Jovanović, D., Ćurčić, M.,& Nedeljković, M.. (2002). Fluoride content in potable water on territory of Vranje. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 772-773.
https://hdl.handle.net/21.15107/rcub_farfar_386

Jovanović D, Ćurčić M, Nedeljković M. Fluoride content in potable water on territory of Vranje. in Arhiv za farmaciju. 2002;52(4):772-773.
https://hdl.handle.net/21.15107/rcub_farfar_386 .

Jovanović, D., Ćurčić, Marijana, Nedeljković, Mirjana, "Fluoride content in potable water on territory of Vranje" in Arhiv za farmaciju, 52, no. 4 (2002):772-773,
https://hdl.handle.net/21.15107/rcub_farfar_386 .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Đukić, Mirjana
AU  - Ćušić, Slavko
AU  - Nedeljković, Mirjana
AU  - Matović, Vesna
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/355
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Determination of morphine and 6-monoacethylmorphine in urine by GC-MS method using derivation
T1  - Određivanje morfina i 6-monoacetilmorfina u urinu gas-masenom spektrometrijom primenom derivatizacije
VL  - 52
IS  - 4
SP  - 764
EP  - 765
UR  - https://hdl.handle.net/21.15107/rcub_farfar_355
ER  - 

@conference{
author = "Ćurčić, Marijana and Đukić, Mirjana and Ćušić, Slavko and Nedeljković, Mirjana and Matović, Vesna",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Determination of morphine and 6-monoacethylmorphine in urine by GC-MS method using derivation, Određivanje morfina i 6-monoacetilmorfina u urinu gas-masenom spektrometrijom primenom derivatizacije",
volume = "52",
number = "4",
pages = "764-765",
url = "https://hdl.handle.net/21.15107/rcub_farfar_355"
}

Ćurčić, M., Đukić, M., Ćušić, S., Nedeljković, M.,& Matović, V.. (2002). Determination of morphine and 6-monoacethylmorphine in urine by GC-MS method using derivation. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 764-765.
https://hdl.handle.net/21.15107/rcub_farfar_355

Ćurčić M, Đukić M, Ćušić S, Nedeljković M, Matović V. Determination of morphine and 6-monoacethylmorphine in urine by GC-MS method using derivation. in Arhiv za farmaciju. 2002;52(4):764-765.
https://hdl.handle.net/21.15107/rcub_farfar_355 .

Ćurčić, Marijana, Đukić, Mirjana, Ćušić, Slavko, Nedeljković, Mirjana, Matović, Vesna, "Determination of morphine and 6-monoacethylmorphine in urine by GC-MS method using derivation" in Arhiv za farmaciju, 52, no. 4 (2002):764-765,
https://hdl.handle.net/21.15107/rcub_farfar_355 .

TY  - CONF
AU  - Đukić, Mirjana
AU  - Jovanović, Marina
AU  - Nedeljković, Mirjana
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/358
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Influence of disulfiram treatment on 5-HIAA excretions in alcoholics
T1  - Uticaj terapije disulfiramom na 5-HIAA ekskreciju kod alkoholičara
VL  - 52
IS  - 4
SP  - 766
EP  - 767
UR  - https://hdl.handle.net/21.15107/rcub_farfar_358
ER  - 

@conference{
author = "Đukić, Mirjana and Jovanović, Marina and Nedeljković, Mirjana",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Influence of disulfiram treatment on 5-HIAA excretions in alcoholics, Uticaj terapije disulfiramom na 5-HIAA ekskreciju kod alkoholičara",
volume = "52",
number = "4",
pages = "766-767",
url = "https://hdl.handle.net/21.15107/rcub_farfar_358"
}

Đukić, M., Jovanović, M.,& Nedeljković, M.. (2002). Influence of disulfiram treatment on 5-HIAA excretions in alcoholics. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 766-767.
https://hdl.handle.net/21.15107/rcub_farfar_358

Đukić M, Jovanović M, Nedeljković M. Influence of disulfiram treatment on 5-HIAA excretions in alcoholics. in Arhiv za farmaciju. 2002;52(4):766-767.
https://hdl.handle.net/21.15107/rcub_farfar_358 .

Đukić, Mirjana, Jovanović, Marina, Nedeljković, Mirjana, "Influence of disulfiram treatment on 5-HIAA excretions in alcoholics" in Arhiv za farmaciju, 52, no. 4 (2002):766-767,
https://hdl.handle.net/21.15107/rcub_farfar_358 .

TY  - CONF
AU  - Vidojević, J.
AU  - Antonijević, Biljana
AU  - Nedeljković, Mirjana
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/330
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - The content of trihalomethanes in drinking water of the Čačak region
T1  - Sadržaj trihalometana u vodi za piće područja Čačka
VL  - 52
IS  - 4
SP  - 786
EP  - 787
UR  - https://hdl.handle.net/21.15107/rcub_farfar_330
ER  - 

@conference{
author = "Vidojević, J. and Antonijević, Biljana and Nedeljković, Mirjana",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "The content of trihalomethanes in drinking water of the Čačak region, Sadržaj trihalometana u vodi za piće područja Čačka",
volume = "52",
number = "4",
pages = "786-787",
url = "https://hdl.handle.net/21.15107/rcub_farfar_330"
}

Vidojević, J., Antonijević, B.,& Nedeljković, M.. (2002). The content of trihalomethanes in drinking water of the Čačak region. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 786-787.
https://hdl.handle.net/21.15107/rcub_farfar_330

Vidojević J, Antonijević B, Nedeljković M. The content of trihalomethanes in drinking water of the Čačak region. in Arhiv za farmaciju. 2002;52(4):786-787.
https://hdl.handle.net/21.15107/rcub_farfar_330 .

Vidojević, J., Antonijević, Biljana, Nedeljković, Mirjana, "The content of trihalomethanes in drinking water of the Čačak region" in Arhiv za farmaciju, 52, no. 4 (2002):786-787,
https://hdl.handle.net/21.15107/rcub_farfar_330 .

TY  - CONF
AU  - Tolić, T.
AU  - Đukić, Danijela
AU  - Nedeljković, Mirjana
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/354
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Toxic metals and nonmetals in lipsticks - total contents and soluble parts
T1  - Toksični metali i nemetali u ruževima za usne - ukupan sadržaj i rastvorni deo
VL  - 52
IS  - 4
SP  - 782
EP  - 783
UR  - https://hdl.handle.net/21.15107/rcub_farfar_354
ER  - 

@conference{
author = "Tolić, T. and Đukić, Danijela and Nedeljković, Mirjana",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Toxic metals and nonmetals in lipsticks - total contents and soluble parts, Toksični metali i nemetali u ruževima za usne - ukupan sadržaj i rastvorni deo",
volume = "52",
number = "4",
pages = "782-783",
url = "https://hdl.handle.net/21.15107/rcub_farfar_354"
}

Tolić, T., Đukić, D.,& Nedeljković, M.. (2002). Toxic metals and nonmetals in lipsticks - total contents and soluble parts. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 782-783.
https://hdl.handle.net/21.15107/rcub_farfar_354

Tolić T, Đukić D, Nedeljković M. Toxic metals and nonmetals in lipsticks - total contents and soluble parts. in Arhiv za farmaciju. 2002;52(4):782-783.
https://hdl.handle.net/21.15107/rcub_farfar_354 .

Tolić, T., Đukić, Danijela, Nedeljković, Mirjana, "Toxic metals and nonmetals in lipsticks - total contents and soluble parts" in Arhiv za farmaciju, 52, no. 4 (2002):782-783,
https://hdl.handle.net/21.15107/rcub_farfar_354 .

TY  - CONF
AU  - Antonijević, Biljana
AU  - Stefanović, Danka
AU  - Nedeljković, Mirjana
AU  - Stojiljković, Miloš P.
AU  - Bokonjić, Dubravko
AU  - Milovanović, Zoran A.
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/368
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Protective effect of standard antidotes along with sodium bicarbonate in rats poisoned with dichlorvos
T1  - Zaštitni efekat standardnih antidota primenjenih sa natrijum bikarbonatom u pacova trovanih dihlorvosom
VL  - 52
IS  - 4
SP  - 762
EP  - 763
UR  - https://hdl.handle.net/21.15107/rcub_farfar_368
ER  - 

@conference{
author = "Antonijević, Biljana and Stefanović, Danka and Nedeljković, Mirjana and Stojiljković, Miloš P. and Bokonjić, Dubravko and Milovanović, Zoran A.",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Protective effect of standard antidotes along with sodium bicarbonate in rats poisoned with dichlorvos, Zaštitni efekat standardnih antidota primenjenih sa natrijum bikarbonatom u pacova trovanih dihlorvosom",
volume = "52",
number = "4",
pages = "762-763",
url = "https://hdl.handle.net/21.15107/rcub_farfar_368"
}

Antonijević, B., Stefanović, D., Nedeljković, M., Stojiljković, M. P., Bokonjić, D.,& Milovanović, Z. A.. (2002). Protective effect of standard antidotes along with sodium bicarbonate in rats poisoned with dichlorvos. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 762-763.
https://hdl.handle.net/21.15107/rcub_farfar_368

Antonijević B, Stefanović D, Nedeljković M, Stojiljković MP, Bokonjić D, Milovanović ZA. Protective effect of standard antidotes along with sodium bicarbonate in rats poisoned with dichlorvos. in Arhiv za farmaciju. 2002;52(4):762-763.
https://hdl.handle.net/21.15107/rcub_farfar_368 .

Antonijević, Biljana, Stefanović, Danka, Nedeljković, Mirjana, Stojiljković, Miloš P., Bokonjić, Dubravko, Milovanović, Zoran A., "Protective effect of standard antidotes along with sodium bicarbonate in rats poisoned with dichlorvos" in Arhiv za farmaciju, 52, no. 4 (2002):762-763,
https://hdl.handle.net/21.15107/rcub_farfar_368 .

TY  - JOUR
AU  - Antonijević, Biljana
AU  - Maksimović, Matej
AU  - Kilibarda, Vesna
AU  - Stojiljković, Miloš P.
AU  - Nedeljković, Mirjana
AU  - Milovanović, Zoran A.
AU  - Bokonjić, Dubravko
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/305
AB  - The aim of this study was to investigate the efficacy of four pyridinium oximes - pralidoxime (PAM-2), trimedoxime (TMB-4), obidoxime (LuH-6) and HI-6 - alone or in combination with memantine and its principal metabolite 1-amino-3-hydroxymethyl-5-methyl adamantane (Mrz 2/373) against soman in mice. Male Albino mice were pretreated iv with oximes and adamantanes at various times before 1.3 LD-50 of soman iv in order to obtain their ED-50t. In a separate experiment, the brain, dia­phragmai and erythrocytic acetylcholinesterase and plasma carboxylesterase activities were determined after sacrificing mice 5 min after soman 0.75 LD-50. Oxime HI-6 (ED-50 value at 5 min before soman) and adamantanes were administered 5 min before soman. In the combination regimens and in the biochemical experiments the dose of memantine and Mrz 2/373 was fixed at 10 mg/kg iv. Along the tested time intervals, HI-6 afforded the best protection of experimental animals, and calculated EDSOo value of HI-6 was 7.96 µmol/kg. Memantine significantly (up to 9 times) de­creased ED-500 values of all the oximes used, with the exception of TMB-4. Among tested tis­sues, the highest recovery of inhibited acetylcholinesterase was obtained in the diaphragm. Co-administration of adamantanes (memantine, Mrz 2/373) produced a statistically significant in­crease in the erythrocyte acetylcholinesterase activity. It could be concluded that memantine antidotal efficacy could be ascribed to the protection of acetylcholinesterase activity. .
AB  - Pored činjenice daje oksim HI-6 najefikasniji u antagonizovanju toksičnih efekata somana, terapija trovanja ovim nervnim bojnim otrovom još nije u potpunosti zadovoljavajuća. Dosadašnji eksperimenti sa memantinom su pokazali da ovaj derivat adamantana potencira terapijski efekat standardnih antidota pri trovanju organofosfornim jedinjenjima. U ovom radu ispitivana je antidotska efikasnost piridinijumskih oksima - pralidoksima, trimedoksima, obidoksima i HI-6, kao i njihovih kombinacija sa memantinom ili njegovim aktivnim metabolitom Mrz 2/373 u miševa trovanih somanom. Radi dobijanja parametara zaštitne efikasnosti antidota, albino miševima mužjacima su iv aplikovane rastuće doze antidota u određenim vremenskim intervalima ( 1 -60 min) pre 1,3 LD-50 iv somana. Aktivnosti acetilholinesteraze mozga, dijafragme i eritrocita, kao i karboksilesteraza plazme, određivane su nakon iv primene adamantana (10 mg/kg) i/ili oksima HI-6 (3,1 mg/kg; 7,96 µmol/kg) datih 5 min pre 0,75 LD-50 iv somana. Primena oksima HI-6 je obezbedila najbolju zaštitu eksperimentalnih životinja, a srednja efektivna doza u nultom vremenu ED-500 iznosila je 7,96 µmol/kg. Kada je primenjen u kombinaciji sa oksimima, memantin je doveo do značajnog (oko 9 puta) smanjenja HD-500 vrednosti svih oksima, osim trimedoksima. ali je zato poluvreme efikasnosti trimedoksima povećano 4,82 puta. Značajan porast acetilholinesteraze dijafragme dobijen je primenom HI-6, memantina kao i njihove kombinacije. U odnosu na grupu koja je primila samo soman, aktivnost acetilholi­nesteraze eritrocita bila je značajno veća u grupama kojima su davani adamantani i/ili HI-6. Nijedan od primenjenih tretmana nije doveo do statistički značajnog povećanja aktivnosti acetilholinesteraze mozga i karboksilesteraza plazme. Bolji zaštitni efekt kombinacija oksima i memantina u odnosu na same oksime mogao bi se pripisati antikonvulzivnom potencijalu memantina, koji je nekompetitivni antagonista NMDA receptora, ali i izvesnoj zaštiti aktivnog centra acetilholinesteraze dijafragme.
PB  - Srpsko lekarsko društvo - Sekcija za toksikologiju, Beograd
T2  - Archives of Toxicology, Kinetics and Xenobiotic Metabolism
T1  - Potential beneficial action of adamantanes in mice poisoned with soman
T1  - Potencijalna uloga adamantana u trovanju miševa somanom
VL  - 9
IS  - 1-2
SP  - 13
EP  - 20
UR  - https://hdl.handle.net/21.15107/rcub_farfar_305
ER  - 

@article{
author = "Antonijević, Biljana and Maksimović, Matej and Kilibarda, Vesna and Stojiljković, Miloš P. and Nedeljković, Mirjana and Milovanović, Zoran A. and Bokonjić, Dubravko",
year = "2001",
abstract = "The aim of this study was to investigate the efficacy of four pyridinium oximes - pralidoxime (PAM-2), trimedoxime (TMB-4), obidoxime (LuH-6) and HI-6 - alone or in combination with memantine and its principal metabolite 1-amino-3-hydroxymethyl-5-methyl adamantane (Mrz 2/373) against soman in mice. Male Albino mice were pretreated iv with oximes and adamantanes at various times before 1.3 LD-50 of soman iv in order to obtain their ED-50t. In a separate experiment, the brain, dia­phragmai and erythrocytic acetylcholinesterase and plasma carboxylesterase activities were determined after sacrificing mice 5 min after soman 0.75 LD-50. Oxime HI-6 (ED-50 value at 5 min before soman) and adamantanes were administered 5 min before soman. In the combination regimens and in the biochemical experiments the dose of memantine and Mrz 2/373 was fixed at 10 mg/kg iv. Along the tested time intervals, HI-6 afforded the best protection of experimental animals, and calculated EDSOo value of HI-6 was 7.96 µmol/kg. Memantine significantly (up to 9 times) de­creased ED-500 values of all the oximes used, with the exception of TMB-4. Among tested tis­sues, the highest recovery of inhibited acetylcholinesterase was obtained in the diaphragm. Co-administration of adamantanes (memantine, Mrz 2/373) produced a statistically significant in­crease in the erythrocyte acetylcholinesterase activity. It could be concluded that memantine antidotal efficacy could be ascribed to the protection of acetylcholinesterase activity. ., Pored činjenice daje oksim HI-6 najefikasniji u antagonizovanju toksičnih efekata somana, terapija trovanja ovim nervnim bojnim otrovom još nije u potpunosti zadovoljavajuća. Dosadašnji eksperimenti sa memantinom su pokazali da ovaj derivat adamantana potencira terapijski efekat standardnih antidota pri trovanju organofosfornim jedinjenjima. U ovom radu ispitivana je antidotska efikasnost piridinijumskih oksima - pralidoksima, trimedoksima, obidoksima i HI-6, kao i njihovih kombinacija sa memantinom ili njegovim aktivnim metabolitom Mrz 2/373 u miševa trovanih somanom. Radi dobijanja parametara zaštitne efikasnosti antidota, albino miševima mužjacima su iv aplikovane rastuće doze antidota u određenim vremenskim intervalima ( 1 -60 min) pre 1,3 LD-50 iv somana. Aktivnosti acetilholinesteraze mozga, dijafragme i eritrocita, kao i karboksilesteraza plazme, određivane su nakon iv primene adamantana (10 mg/kg) i/ili oksima HI-6 (3,1 mg/kg; 7,96 µmol/kg) datih 5 min pre 0,75 LD-50 iv somana. Primena oksima HI-6 je obezbedila najbolju zaštitu eksperimentalnih životinja, a srednja efektivna doza u nultom vremenu ED-500 iznosila je 7,96 µmol/kg. Kada je primenjen u kombinaciji sa oksimima, memantin je doveo do značajnog (oko 9 puta) smanjenja HD-500 vrednosti svih oksima, osim trimedoksima. ali je zato poluvreme efikasnosti trimedoksima povećano 4,82 puta. Značajan porast acetilholinesteraze dijafragme dobijen je primenom HI-6, memantina kao i njihove kombinacije. U odnosu na grupu koja je primila samo soman, aktivnost acetilholi­nesteraze eritrocita bila je značajno veća u grupama kojima su davani adamantani i/ili HI-6. Nijedan od primenjenih tretmana nije doveo do statistički značajnog povećanja aktivnosti acetilholinesteraze mozga i karboksilesteraza plazme. Bolji zaštitni efekt kombinacija oksima i memantina u odnosu na same oksime mogao bi se pripisati antikonvulzivnom potencijalu memantina, koji je nekompetitivni antagonista NMDA receptora, ali i izvesnoj zaštiti aktivnog centra acetilholinesteraze dijafragme.",
publisher = "Srpsko lekarsko društvo - Sekcija za toksikologiju, Beograd",
journal = "Archives of Toxicology, Kinetics and Xenobiotic Metabolism",
title = "Potential beneficial action of adamantanes in mice poisoned with soman, Potencijalna uloga adamantana u trovanju miševa somanom",
volume = "9",
number = "1-2",
pages = "13-20",
url = "https://hdl.handle.net/21.15107/rcub_farfar_305"
}

Antonijević, B., Maksimović, M., Kilibarda, V., Stojiljković, M. P., Nedeljković, M., Milovanović, Z. A.,& Bokonjić, D.. (2001). Potential beneficial action of adamantanes in mice poisoned with soman. in Archives of Toxicology, Kinetics and Xenobiotic Metabolism
Srpsko lekarsko društvo - Sekcija za toksikologiju, Beograd., 9(1-2), 13-20.
https://hdl.handle.net/21.15107/rcub_farfar_305

Antonijević B, Maksimović M, Kilibarda V, Stojiljković MP, Nedeljković M, Milovanović ZA, Bokonjić D. Potential beneficial action of adamantanes in mice poisoned with soman. in Archives of Toxicology, Kinetics and Xenobiotic Metabolism. 2001;9(1-2):13-20.
https://hdl.handle.net/21.15107/rcub_farfar_305 .

Antonijević, Biljana, Maksimović, Matej, Kilibarda, Vesna, Stojiljković, Miloš P., Nedeljković, Mirjana, Milovanović, Zoran A., Bokonjić, Dubravko, "Potential beneficial action of adamantanes in mice poisoned with soman" in Archives of Toxicology, Kinetics and Xenobiotic Metabolism, 9, no. 1-2 (2001):13-20,
https://hdl.handle.net/21.15107/rcub_farfar_305 .

TY  - JOUR
AU  - Antonijević, Biljana
AU  - Maksimović, M.
AU  - Stojiljković, Miloš P.
AU  - Nedeljković, Mirjana
AU  - Đukić, Mirjana
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/274
PB  - Srpsko lekarsko društvo - Sekcija za toksikologiju, Beograd
T2  - Archives of Toxicology, Kinetics and Xenobiotic Metabolism
T1  - Protective effects of memantine and pyridinium oximes in mice poisoned with dichlorvos
T1  - Zaštitni efekti memantina i piridinijumskih oksima u miševa trovanih dihlorvosom
VL  - 8
IS  - 3
SP  - 216
EP  - 217
UR  - https://hdl.handle.net/21.15107/rcub_farfar_274
ER  - 

@article{
author = "Antonijević, Biljana and Maksimović, M. and Stojiljković, Miloš P. and Nedeljković, Mirjana and Đukić, Mirjana",
year = "2000",
publisher = "Srpsko lekarsko društvo - Sekcija za toksikologiju, Beograd",
journal = "Archives of Toxicology, Kinetics and Xenobiotic Metabolism",
title = "Protective effects of memantine and pyridinium oximes in mice poisoned with dichlorvos, Zaštitni efekti memantina i piridinijumskih oksima u miševa trovanih dihlorvosom",
volume = "8",
number = "3",
pages = "216-217",
url = "https://hdl.handle.net/21.15107/rcub_farfar_274"
}

Antonijević, B., Maksimović, M., Stojiljković, M. P., Nedeljković, M.,& Đukić, M.. (2000). Protective effects of memantine and pyridinium oximes in mice poisoned with dichlorvos. in Archives of Toxicology, Kinetics and Xenobiotic Metabolism
Srpsko lekarsko društvo - Sekcija za toksikologiju, Beograd., 8(3), 216-217.
https://hdl.handle.net/21.15107/rcub_farfar_274

Antonijević B, Maksimović M, Stojiljković MP, Nedeljković M, Đukić M. Protective effects of memantine and pyridinium oximes in mice poisoned with dichlorvos. in Archives of Toxicology, Kinetics and Xenobiotic Metabolism. 2000;8(3):216-217.
https://hdl.handle.net/21.15107/rcub_farfar_274 .

Antonijević, Biljana, Maksimović, M., Stojiljković, Miloš P., Nedeljković, Mirjana, Đukić, Mirjana, "Protective effects of memantine and pyridinium oximes in mice poisoned with dichlorvos" in Archives of Toxicology, Kinetics and Xenobiotic Metabolism, 8, no. 3 (2000):216-217,
https://hdl.handle.net/21.15107/rcub_farfar_274 .