TY  - CONF
AU  - Cvetanović, Aleksandra
AU  - Pavlić, Branimir
AU  - Ražić, Slavica
AU  - Arsenijević, Jelena
AU  - Zengin, Gokhan
AU  - Uysal, Sengul
AU  - Zeković, Zoran
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5275
AB  - U okviru ovog rada cvast kamilice je ekstrahovana primenom dve različite tehnike, sa ciljem dobijanja proizvoda bogatog bioaktivnim jedinjenjima i funkcionalnim sastojcima. Za ovu svrhu, primenjena je jedna konvencionalna (Soxhlet extrakcija - SE) i jedna nekonvencionalna (superkritična ekstrakcija - SFE) tehnika. Detaljni hemijski sasatav SE i SFE ekstrakata je analiziran primenom GC - MS. Dodatno, izvršena je i procena biološke aktivnosti dobijenih ekstrakata. Prinos lipofine frakcije dobijene nakon tročasovne ekstrakcije čistim ugljen-dioksidom (350 bar i 40 °C) je bio približan prinosu ostvarenom SE ekstrakcijom u trajanju od 6 h pomoću metilen hlorida. Ispitivanje ekstarkata u smislu inhibicije acetilholinesteraze (AChE) i butirilholinesteraze (BChE) je pokazalo veći enzim-inhibitorni potencijala SFE uzorka. Imajući u vidu „zeleni" karakter i bezbednost SFE ekstrakata, prepoznat je veliki potencijal i mogućnost njihove primene kao sastojaka različitih prehrambenih funkcionalnih proizvoda, kao i brojnih farmaceutskih preparata.
AB  - In this study chamomile was extracted applying two different techniques in order to obtain the extract opulent with bioactive compounds. For this purpose one conventional (Soxhlet - SE) and one non-conventional (Supercritical fluid extraction - SFE) extraction technique were used. Detailed chemical composition of SE and SFE extracts was analysed by GC - MS. Additionally, biological activity of the chamomile products was examined as well. The yield of lipophilic fraction, achieved by 3h extraction, with CO2 at 350 bar and 40 °C was close to that one produced by Soxhlet performed for 6 h with methylene chloride. On the other hand, examination of their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) showed much higher enzyme-inhibitory potential of SFE extracts. Due to their green character and safety, SFE extracts have a great potential and possibilities for their use as ingredients in both numerous functional food products and pharmaceutical products, are recognized.
PB  - Univerzitet u Beogradu
C3  - UNIFOOD Konferencija, Beograd, 5-6 oktobar 2018, Program i zbornik radova
T1  - Savremen pristup dobijanja funkcionalnih sastojaka kamilice
T1  - Emerging approach for the preparation of chamomile functional ingredients
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5275
ER  - 

@conference{
author = "Cvetanović, Aleksandra and Pavlić, Branimir and Ražić, Slavica and Arsenijević, Jelena and Zengin, Gokhan and Uysal, Sengul and Zeković, Zoran",
year = "2018",
abstract = "U okviru ovog rada cvast kamilice je ekstrahovana primenom dve različite tehnike, sa ciljem dobijanja proizvoda bogatog bioaktivnim jedinjenjima i funkcionalnim sastojcima. Za ovu svrhu, primenjena je jedna konvencionalna (Soxhlet extrakcija - SE) i jedna nekonvencionalna (superkritična ekstrakcija - SFE) tehnika. Detaljni hemijski sasatav SE i SFE ekstrakata je analiziran primenom GC - MS. Dodatno, izvršena je i procena biološke aktivnosti dobijenih ekstrakata. Prinos lipofine frakcije dobijene nakon tročasovne ekstrakcije čistim ugljen-dioksidom (350 bar i 40 °C) je bio približan prinosu ostvarenom SE ekstrakcijom u trajanju od 6 h pomoću metilen hlorida. Ispitivanje ekstarkata u smislu inhibicije acetilholinesteraze (AChE) i butirilholinesteraze (BChE) je pokazalo veći enzim-inhibitorni potencijala SFE uzorka. Imajući u vidu „zeleni" karakter i bezbednost SFE ekstrakata, prepoznat je veliki potencijal i mogućnost njihove primene kao sastojaka različitih prehrambenih funkcionalnih proizvoda, kao i brojnih farmaceutskih preparata., In this study chamomile was extracted applying two different techniques in order to obtain the extract opulent with bioactive compounds. For this purpose one conventional (Soxhlet - SE) and one non-conventional (Supercritical fluid extraction - SFE) extraction technique were used. Detailed chemical composition of SE and SFE extracts was analysed by GC - MS. Additionally, biological activity of the chamomile products was examined as well. The yield of lipophilic fraction, achieved by 3h extraction, with CO2 at 350 bar and 40 °C was close to that one produced by Soxhlet performed for 6 h with methylene chloride. On the other hand, examination of their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) showed much higher enzyme-inhibitory potential of SFE extracts. Due to their green character and safety, SFE extracts have a great potential and possibilities for their use as ingredients in both numerous functional food products and pharmaceutical products, are recognized.",
publisher = "Univerzitet u Beogradu",
journal = "UNIFOOD Konferencija, Beograd, 5-6 oktobar 2018, Program i zbornik radova",
title = "Savremen pristup dobijanja funkcionalnih sastojaka kamilice, Emerging approach for the preparation of chamomile functional ingredients",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5275"
}

Cvetanović, A., Pavlić, B., Ražić, S., Arsenijević, J., Zengin, G., Uysal, S.,& Zeković, Z.. (2018). Savremen pristup dobijanja funkcionalnih sastojaka kamilice. in UNIFOOD Konferencija, Beograd, 5-6 oktobar 2018, Program i zbornik radova
Univerzitet u Beogradu..
https://hdl.handle.net/21.15107/rcub_farfar_5275

Cvetanović A, Pavlić B, Ražić S, Arsenijević J, Zengin G, Uysal S, Zeković Z. Savremen pristup dobijanja funkcionalnih sastojaka kamilice. in UNIFOOD Konferencija, Beograd, 5-6 oktobar 2018, Program i zbornik radova. 2018;.
https://hdl.handle.net/21.15107/rcub_farfar_5275 .

Cvetanović, Aleksandra, Pavlić, Branimir, Ražić, Slavica, Arsenijević, Jelena, Zengin, Gokhan, Uysal, Sengul, Zeković, Zoran, "Savremen pristup dobijanja funkcionalnih sastojaka kamilice" in UNIFOOD Konferencija, Beograd, 5-6 oktobar 2018, Program i zbornik radova (2018),
https://hdl.handle.net/21.15107/rcub_farfar_5275 .