TY  - JOUR
AU  - Stojanović, Ivan
AU  - Okiljević, Bogdan
AU  - Radojičić, Zoran
AU  - Novaković, Aleksandra
AU  - Kaitović, Marko
AU  - Tomić, Slobodan
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4279
AB  - Background: Anterior mitral leaflet prolapse repair is a highly effective procedure, but despite excellent operative results still has an inferior long‐term durability when compared to posterior leaflet repair. Methods: We analysed mitral repair durability in 74 consecutive patients operated for anterior leaflet prolapse between 2010 and 2021. Their pre‐ and postoperative clinical, echocardiographic data and repair durability as well, were compared with 74 randomly assigned posterior leaflet prolapse patients who underwent valve repair during the same period. Results: While groups were of similar age, patients with anterior leaflet prolapse had an inferior preoperative status in terms of functional reserve, atrial fibrillation, operative risk, ejection fraction and had more dilated left heart chambers as well. 1, 5, and 10‐year freedom from repair failure was 87.1 ± 4.6%, 79.8 ± 6.5% and 50.7 ± 12.5% in the anterior, and 98.5 ± 1.5% respectively in the posterior leaflet group. Atrial fibrilation (hazard ratio [HR] 5.365; 95%; confidence interval [CI] 1.093–26.324 p = .038) and left ventricle end‐systolic diameter (HR 1.160 95%; CI 1.037–1.299 p = .010) independently predicted anterior leaflet repair failure. Receiver Operating Curve analysis established left ventricle end‐systolic diameter ≤42 mm as a cut‐off value associated with improved anterior leaflet repair durability. Accordingly, 10‐year repair durability in a subset of patients, with preserved left ventricle end‐systolic diameter (≤42 mm) was 86.4 ± 7.8%. Conclusion: Better long‐term repair durability in patients with anterior mitral leaflet prolapse and preserved sinus rhytm and left‐ventricle diameters justifies early reconstructive approach.
PB  - John Wiley and Sons Inc
T2  - Journal of Cardiac Surgery
T1  - Clinical and echocardiographic predictors of the anterior mitral leaflet repair failure
IS  - 37
SP  - 3567
EP  - 3574
DO  - 10.1111/jocs.16945
ER  - 

@article{
author = "Stojanović, Ivan and Okiljević, Bogdan and Radojičić, Zoran and Novaković, Aleksandra and Kaitović, Marko and Tomić, Slobodan",
year = "2022",
abstract = "Background: Anterior mitral leaflet prolapse repair is a highly effective procedure, but despite excellent operative results still has an inferior long‐term durability when compared to posterior leaflet repair. Methods: We analysed mitral repair durability in 74 consecutive patients operated for anterior leaflet prolapse between 2010 and 2021. Their pre‐ and postoperative clinical, echocardiographic data and repair durability as well, were compared with 74 randomly assigned posterior leaflet prolapse patients who underwent valve repair during the same period. Results: While groups were of similar age, patients with anterior leaflet prolapse had an inferior preoperative status in terms of functional reserve, atrial fibrillation, operative risk, ejection fraction and had more dilated left heart chambers as well. 1, 5, and 10‐year freedom from repair failure was 87.1 ± 4.6%, 79.8 ± 6.5% and 50.7 ± 12.5% in the anterior, and 98.5 ± 1.5% respectively in the posterior leaflet group. Atrial fibrilation (hazard ratio [HR] 5.365; 95%; confidence interval [CI] 1.093–26.324 p = .038) and left ventricle end‐systolic diameter (HR 1.160 95%; CI 1.037–1.299 p = .010) independently predicted anterior leaflet repair failure. Receiver Operating Curve analysis established left ventricle end‐systolic diameter ≤42 mm as a cut‐off value associated with improved anterior leaflet repair durability. Accordingly, 10‐year repair durability in a subset of patients, with preserved left ventricle end‐systolic diameter (≤42 mm) was 86.4 ± 7.8%. Conclusion: Better long‐term repair durability in patients with anterior mitral leaflet prolapse and preserved sinus rhytm and left‐ventricle diameters justifies early reconstructive approach.",
publisher = "John Wiley and Sons Inc",
journal = "Journal of Cardiac Surgery",
title = "Clinical and echocardiographic predictors of the anterior mitral leaflet repair failure",
number = "37",
pages = "3567-3574",
doi = "10.1111/jocs.16945"
}

Stojanović, I., Okiljević, B., Radojičić, Z., Novaković, A., Kaitović, M.,& Tomić, S.. (2022). Clinical and echocardiographic predictors of the anterior mitral leaflet repair failure. in Journal of Cardiac Surgery
John Wiley and Sons Inc.(37), 3567-3574.
https://doi.org/10.1111/jocs.16945

Stojanović I, Okiljević B, Radojičić Z, Novaković A, Kaitović M, Tomić S. Clinical and echocardiographic predictors of the anterior mitral leaflet repair failure. in Journal of Cardiac Surgery. 2022;(37):3567-3574.
doi:10.1111/jocs.16945 .

Stojanović, Ivan, Okiljević, Bogdan, Radojičić, Zoran, Novaković, Aleksandra, Kaitović, Marko, Tomić, Slobodan, "Clinical and echocardiographic predictors of the anterior mitral leaflet repair failure" in Journal of Cardiac Surgery, no. 37 (2022):3567-3574,
https://doi.org/10.1111/jocs.16945 . .

TY  - JOUR
AU  - Stojanović, Ivan
AU  - Kaitović, Marko
AU  - Novaković, Aleksandra
AU  - Vuković, Petar
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3273
AB  - Introduction. Mitral valve calcifications are frequent finding in Barlow disease. This is making mitral repair surgery even more demanding in already complex valve pathology. Case report. A fifty-five-year-old Barlow disease patient underwent a mitral repair surgery due to posterior leaflet prolapse at P2 level and extensive posterior leaflet and annular calcifications as well. The prolapsed scallop was resected, while P1 and P3 scallops were detached from the annulus. After complete posterior annulus decalcification, so formed the large atrio-ventricular defect was reconstructed with the autologous pericardial patch and double suture line technique. The P1 and P3 segments were reattached there by the sliding technique and sutured with no strain. Annuloplasty was performed with a saddle rigid ring No 36. The patient was discharged nine days after the surgery with just a trace of mitral regurgitation. Conclusion. Annular decalcification and reconstruction in the patients with calcified Barlow mitral disease is necessary for safe and durable mitral valve surgical repair.
AB  - Uvod. Kalcifikacije mitralne valvule su čest nalaz kod bolesnika sa Barlovljevom bolesti što čini rekonstruktivnu hirurgiju zalistka kod ovih bolesnika znatno složenijom. Prikaz bolesnika. Bolesniku starom 55 godina je urađena rekonstrukcija mitralnog zalistka zbog prolapsa posteriornog listića i značajnih kalcifikacija na P2 segmentu i posteriornom anulusu. Nakon resekcije P2 segmenta i odvajanja P1 i P3 segmenta od anulusa, urađena je kompletna resekcija velikog kalcifikata sa skoro polovine obima posteriornog anulusa. Nastali atrioventrikularnog defekt rekonstruisan je autolognim perikardom elipsoidnog oblika sašivenim u dva sloja. P1 i P3 segment su potom reinplantirani na rekonstruisani anulus i međusobno spojeni. Rekonstruktivna procedura je kompletirana anuloplastikom pomoću sedlastog rigidnog prstena veličine 36. Bolesnik je otpušten devetog postoperativnog dana sa neznatnom mitralnom regurgitacijom. Zaključak. Dekalcifikacija posteriornog anulusa uz preciznu rekonstrukciju nastalog atrioventikularnog defekta je neophodna procedura za bezbednu i funkcionalno trajnu rekonstrukciju mitralnog zalistka.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Reconstructive surgery of an extremely calcified mitral valve in a Barlow disease patient: A case report
T1  - Rekonstruktivna hirurgija ekstremno kalcifikovane mitralne valvule kod bolesnika sa Barlovljevom bolesti
VL  - 76
IS  - 5
SP  - 552
EP  - 554
DO  - 10.2298/VSP170312117S
ER  - 

@article{
author = "Stojanović, Ivan and Kaitović, Marko and Novaković, Aleksandra and Vuković, Petar",
year = "2019",
abstract = "Introduction. Mitral valve calcifications are frequent finding in Barlow disease. This is making mitral repair surgery even more demanding in already complex valve pathology. Case report. A fifty-five-year-old Barlow disease patient underwent a mitral repair surgery due to posterior leaflet prolapse at P2 level and extensive posterior leaflet and annular calcifications as well. The prolapsed scallop was resected, while P1 and P3 scallops were detached from the annulus. After complete posterior annulus decalcification, so formed the large atrio-ventricular defect was reconstructed with the autologous pericardial patch and double suture line technique. The P1 and P3 segments were reattached there by the sliding technique and sutured with no strain. Annuloplasty was performed with a saddle rigid ring No 36. The patient was discharged nine days after the surgery with just a trace of mitral regurgitation. Conclusion. Annular decalcification and reconstruction in the patients with calcified Barlow mitral disease is necessary for safe and durable mitral valve surgical repair., Uvod. Kalcifikacije mitralne valvule su čest nalaz kod bolesnika sa Barlovljevom bolesti što čini rekonstruktivnu hirurgiju zalistka kod ovih bolesnika znatno složenijom. Prikaz bolesnika. Bolesniku starom 55 godina je urađena rekonstrukcija mitralnog zalistka zbog prolapsa posteriornog listića i značajnih kalcifikacija na P2 segmentu i posteriornom anulusu. Nakon resekcije P2 segmenta i odvajanja P1 i P3 segmenta od anulusa, urađena je kompletna resekcija velikog kalcifikata sa skoro polovine obima posteriornog anulusa. Nastali atrioventrikularnog defekt rekonstruisan je autolognim perikardom elipsoidnog oblika sašivenim u dva sloja. P1 i P3 segment su potom reinplantirani na rekonstruisani anulus i međusobno spojeni. Rekonstruktivna procedura je kompletirana anuloplastikom pomoću sedlastog rigidnog prstena veličine 36. Bolesnik je otpušten devetog postoperativnog dana sa neznatnom mitralnom regurgitacijom. Zaključak. Dekalcifikacija posteriornog anulusa uz preciznu rekonstrukciju nastalog atrioventikularnog defekta je neophodna procedura za bezbednu i funkcionalno trajnu rekonstrukciju mitralnog zalistka.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Reconstructive surgery of an extremely calcified mitral valve in a Barlow disease patient: A case report, Rekonstruktivna hirurgija ekstremno kalcifikovane mitralne valvule kod bolesnika sa Barlovljevom bolesti",
volume = "76",
number = "5",
pages = "552-554",
doi = "10.2298/VSP170312117S"
}

Stojanović, I., Kaitović, M., Novaković, A.,& Vuković, P.. (2019). Reconstructive surgery of an extremely calcified mitral valve in a Barlow disease patient: A case report. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(5), 552-554.
https://doi.org/10.2298/VSP170312117S

Stojanović I, Kaitović M, Novaković A, Vuković P. Reconstructive surgery of an extremely calcified mitral valve in a Barlow disease patient: A case report. in Vojnosanitetski pregled. 2019;76(5):552-554.
doi:10.2298/VSP170312117S .

Stojanović, Ivan, Kaitović, Marko, Novaković, Aleksandra, Vuković, Petar, "Reconstructive surgery of an extremely calcified mitral valve in a Barlow disease patient: A case report" in Vojnosanitetski pregled, 76, no. 5 (2019):552-554,
https://doi.org/10.2298/VSP170312117S . .