TY  - JOUR
AU  - Liabeuf, Sophie
AU  - Pepin, , Marion
AU  - Franssen, Casper F.M.
AU  - Viggiano, Davide
AU  - Carriazo, Sol
AU  - Gansevoort, Ron T.
AU  - Gesualdo, Loreto
AU  - Hafez, Gaye
AU  - Malyszko, Jolanta
AU  - Mayer, Christopher
AU  - Nitsch, Dorothea
AU  - Ortiz, Alberto
AU  - Pešić, Vesna
AU  - Wiecek, Andrzej
AU  - Massy, Ziad
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4029
AB  - Chronic kidney disease (CKD) perturbs the crosstalk with others organs, with the interaction between the kidneys and the heart having been studied most intensively. However, a growing body of data indicates that there is an association between kidney dysfunction and disorders of the central nervous system. In epidemiological studies, CKD is associated with a high prevalence of neurological complications, such as cerebrovascular disorders, movement disorders, cognitive impairment and depression. Along with traditional cardiovascular risk factors (such as diabetes, inflammation, hypertension and dyslipidaemia), non-traditional risk factors related to kidney damage (such as uraemic toxins) may predispose patients with CKD to neurological disorders. There is increasing evidence to show that uraemic toxins, for example indoxyl sulphate, have a neurotoxic effect. A better understanding of factors responsible for the elevated prevalence of neurological disorders among patients with CKD might facilitate the development of novel treatments. Here, we review (i) the potential clinical impact of CKD on cerebrovascular and neurological complications, (ii) the mechanisms underlying the uraemic toxins' putative action (based on pre-clinical and clinical research) and (iii) the potential impact of these findings on patient care.
PB  - Oxford University Press
T2  - Nephrology Dialysis Transplantation
T1  - Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?
VL  - 37
IS  - supplement 2
SP  - ii33
EP  - ii44
DO  - 10.1093/ndt/gfab223
ER  - 

@article{
author = "Liabeuf, Sophie and Pepin, , Marion and Franssen, Casper F.M. and Viggiano, Davide and Carriazo, Sol and Gansevoort, Ron T. and Gesualdo, Loreto and Hafez, Gaye and Malyszko, Jolanta and Mayer, Christopher and Nitsch, Dorothea and Ortiz, Alberto and Pešić, Vesna and Wiecek, Andrzej and Massy, Ziad",
year = "2022",
abstract = "Chronic kidney disease (CKD) perturbs the crosstalk with others organs, with the interaction between the kidneys and the heart having been studied most intensively. However, a growing body of data indicates that there is an association between kidney dysfunction and disorders of the central nervous system. In epidemiological studies, CKD is associated with a high prevalence of neurological complications, such as cerebrovascular disorders, movement disorders, cognitive impairment and depression. Along with traditional cardiovascular risk factors (such as diabetes, inflammation, hypertension and dyslipidaemia), non-traditional risk factors related to kidney damage (such as uraemic toxins) may predispose patients with CKD to neurological disorders. There is increasing evidence to show that uraemic toxins, for example indoxyl sulphate, have a neurotoxic effect. A better understanding of factors responsible for the elevated prevalence of neurological disorders among patients with CKD might facilitate the development of novel treatments. Here, we review (i) the potential clinical impact of CKD on cerebrovascular and neurological complications, (ii) the mechanisms underlying the uraemic toxins' putative action (based on pre-clinical and clinical research) and (iii) the potential impact of these findings on patient care.",
publisher = "Oxford University Press",
journal = "Nephrology Dialysis Transplantation",
title = "Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?",
volume = "37",
number = "supplement 2",
pages = "ii33-ii44",
doi = "10.1093/ndt/gfab223"
}

Liabeuf, S., Pepin, ,. M., Franssen, C. F.M., Viggiano, D., Carriazo, S., Gansevoort, R. T., Gesualdo, L., Hafez, G., Malyszko, J., Mayer, C., Nitsch, D., Ortiz, A., Pešić, V., Wiecek, A.,& Massy, Z.. (2022). Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?. in Nephrology Dialysis Transplantation
Oxford University Press., 37(supplement 2), ii33-ii44.
https://doi.org/10.1093/ndt/gfab223

Liabeuf S, Pepin ,M, Franssen CF, Viggiano D, Carriazo S, Gansevoort RT, Gesualdo L, Hafez G, Malyszko J, Mayer C, Nitsch D, Ortiz A, Pešić V, Wiecek A, Massy Z. Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?. in Nephrology Dialysis Transplantation. 2022;37(supplement 2):ii33-ii44.
doi:10.1093/ndt/gfab223 .

Liabeuf, Sophie, Pepin, , Marion, Franssen, Casper F.M., Viggiano, Davide, Carriazo, Sol, Gansevoort, Ron T., Gesualdo, Loreto, Hafez, Gaye, Malyszko, Jolanta, Mayer, Christopher, Nitsch, Dorothea, Ortiz, Alberto, Pešić, Vesna, Wiecek, Andrzej, Massy, Ziad, "Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?" in Nephrology Dialysis Transplantation, 37, no. supplement 2 (2022):ii33-ii44,
https://doi.org/10.1093/ndt/gfab223 . .