TY  - CONF
AU  - Pešić, Vesna
AU  - Dobrosavljević, Ana
AU  - Stanić, Dušanka
AU  - Batinić, Bojan
AU  - Plećaš, Bosiljka
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3299
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Ketamine in a model of depression resistant to tricyclic antidepressants
VL  - 29
IS  - Supplement 1
SP  - S271
EP  - S271
DO  - 10.1016/j.euroneuro.2018.11.430
ER  - 

@conference{
author = "Pešić, Vesna and Dobrosavljević, Ana and Stanić, Dušanka and Batinić, Bojan and Plećaš, Bosiljka",
year = "2019",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Ketamine in a model of depression resistant to tricyclic antidepressants",
volume = "29",
number = "Supplement 1",
pages = "S271-S271",
doi = "10.1016/j.euroneuro.2018.11.430"
}

Pešić, V., Dobrosavljević, A., Stanić, D., Batinić, B.,& Plećaš, B.. (2019). Ketamine in a model of depression resistant to tricyclic antidepressants. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 29(Supplement 1), S271-S271.
https://doi.org/10.1016/j.euroneuro.2018.11.430

Pešić V, Dobrosavljević A, Stanić D, Batinić B, Plećaš B. Ketamine in a model of depression resistant to tricyclic antidepressants. in European Neuropsychopharmacology. 2019;29(Supplement 1):S271-S271.
doi:10.1016/j.euroneuro.2018.11.430 .

Pešić, Vesna, Dobrosavljević, Ana, Stanić, Dušanka, Batinić, Bojan, Plećaš, Bosiljka, "Ketamine in a model of depression resistant to tricyclic antidepressants" in European Neuropsychopharmacology, 29, no. Supplement 1 (2019):S271-S271,
https://doi.org/10.1016/j.euroneuro.2018.11.430 . .

TY  - CONF
AU  - Petrović, Jelena
AU  - Stanić, Dušanka
AU  - Puškaš, Nela
AU  - Oved, K.
AU  - Gurwitz, D.
AU  - Mirković, Duško
AU  - Plećaš, Bosiljka
AU  - Pešić, Vesna
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2870
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Oxytocin promotes neurotrophic growth, increases integrin subunit beta 3 (ITGB3) and ameliorates depressive- and anxiety-like behaviour in rats
VL  - 27
IS  - Supplement 1
SP  - S34
EP  - S35
DO  - 10.1016/S0924-977X(17)30104-9
ER  - 

@conference{
author = "Petrović, Jelena and Stanić, Dušanka and Puškaš, Nela and Oved, K. and Gurwitz, D. and Mirković, Duško and Plećaš, Bosiljka and Pešić, Vesna",
year = "2017",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Oxytocin promotes neurotrophic growth, increases integrin subunit beta 3 (ITGB3) and ameliorates depressive- and anxiety-like behaviour in rats",
volume = "27",
number = "Supplement 1",
pages = "S34-S35",
doi = "10.1016/S0924-977X(17)30104-9"
}

Petrović, J., Stanić, D., Puškaš, N., Oved, K., Gurwitz, D., Mirković, D., Plećaš, B.,& Pešić, V.. (2017). Oxytocin promotes neurotrophic growth, increases integrin subunit beta 3 (ITGB3) and ameliorates depressive- and anxiety-like behaviour in rats. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 27(Supplement 1), S34-S35.
https://doi.org/10.1016/S0924-977X(17)30104-9

Petrović J, Stanić D, Puškaš N, Oved K, Gurwitz D, Mirković D, Plećaš B, Pešić V. Oxytocin promotes neurotrophic growth, increases integrin subunit beta 3 (ITGB3) and ameliorates depressive- and anxiety-like behaviour in rats. in European Neuropsychopharmacology. 2017;27(Supplement 1):S34-S35.
doi:10.1016/S0924-977X(17)30104-9 .

Petrović, Jelena, Stanić, Dušanka, Puškaš, Nela, Oved, K., Gurwitz, D., Mirković, Duško, Plećaš, Bosiljka, Pešić, Vesna, "Oxytocin promotes neurotrophic growth, increases integrin subunit beta 3 (ITGB3) and ameliorates depressive- and anxiety-like behaviour in rats" in European Neuropsychopharmacology, 27, no. Supplement 1 (2017):S34-S35,
https://doi.org/10.1016/S0924-977X(17)30104-9 . .

TY  - CONF
AU  - Petrović, Jelena
AU  - Stanić, Dušanka
AU  - Mirković, Duško
AU  - Batinić, Bojan
AU  - Plećaš, Bosiljka
AU  - Ignjatović, Svetlana
AU  - Pešić, Vesna
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2687
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Effects of long-term magnesium administration on levels of stress hormones and interleukin-6 after acute stress in rats chronically treated with adrenocorticotropic hormone
VL  - 26
IS  - Supplement 2
SP  - S207
EP  - S207
DO  - 10.1016/S0924-977X(16)31053-7
ER  - 

@conference{
author = "Petrović, Jelena and Stanić, Dušanka and Mirković, Duško and Batinić, Bojan and Plećaš, Bosiljka and Ignjatović, Svetlana and Pešić, Vesna",
year = "2016",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Effects of long-term magnesium administration on levels of stress hormones and interleukin-6 after acute stress in rats chronically treated with adrenocorticotropic hormone",
volume = "26",
number = "Supplement 2",
pages = "S207-S207",
doi = "10.1016/S0924-977X(16)31053-7"
}

Petrović, J., Stanić, D., Mirković, D., Batinić, B., Plećaš, B., Ignjatović, S.,& Pešić, V.. (2016). Effects of long-term magnesium administration on levels of stress hormones and interleukin-6 after acute stress in rats chronically treated with adrenocorticotropic hormone. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 26(Supplement 2), S207-S207.
https://doi.org/10.1016/S0924-977X(16)31053-7

Petrović J, Stanić D, Mirković D, Batinić B, Plećaš B, Ignjatović S, Pešić V. Effects of long-term magnesium administration on levels of stress hormones and interleukin-6 after acute stress in rats chronically treated with adrenocorticotropic hormone. in European Neuropsychopharmacology. 2016;26(Supplement 2):S207-S207.
doi:10.1016/S0924-977X(16)31053-7 .

Petrović, Jelena, Stanić, Dušanka, Mirković, Duško, Batinić, Bojan, Plećaš, Bosiljka, Ignjatović, Svetlana, Pešić, Vesna, "Effects of long-term magnesium administration on levels of stress hormones and interleukin-6 after acute stress in rats chronically treated with adrenocorticotropic hormone" in European Neuropsychopharmacology, 26, no. Supplement 2 (2016):S207-S207,
https://doi.org/10.1016/S0924-977X(16)31053-7 . .

TY  - CONF
AU  - Pešić, Vesna
AU  - Stanić, Dušanka
AU  - Petrović, Jelena
AU  - Puskas, Nela
AU  - Plećaš, Bosiljka
AU  - Ignjatović, Svetlana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2656
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Oxytocin affects changes in behaviour, BDNF and Ki-67 expression in hippocampus, caused by chronic corticosterone treatment
VL  - 26
IS  - Supplement 2
SP  - S289
EP  - S289
DO  - 10.1016/S0924-977X(16)31184-1
ER  - 

@conference{
author = "Pešić, Vesna and Stanić, Dušanka and Petrović, Jelena and Puskas, Nela and Plećaš, Bosiljka and Ignjatović, Svetlana",
year = "2016",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Oxytocin affects changes in behaviour, BDNF and Ki-67 expression in hippocampus, caused by chronic corticosterone treatment",
volume = "26",
number = "Supplement 2",
pages = "S289-S289",
doi = "10.1016/S0924-977X(16)31184-1"
}

Pešić, V., Stanić, D., Petrović, J., Puskas, N., Plećaš, B.,& Ignjatović, S.. (2016). Oxytocin affects changes in behaviour, BDNF and Ki-67 expression in hippocampus, caused by chronic corticosterone treatment. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 26(Supplement 2), S289-S289.
https://doi.org/10.1016/S0924-977X(16)31184-1

Pešić V, Stanić D, Petrović J, Puskas N, Plećaš B, Ignjatović S. Oxytocin affects changes in behaviour, BDNF and Ki-67 expression in hippocampus, caused by chronic corticosterone treatment. in European Neuropsychopharmacology. 2016;26(Supplement 2):S289-S289.
doi:10.1016/S0924-977X(16)31184-1 .

Pešić, Vesna, Stanić, Dušanka, Petrović, Jelena, Puskas, Nela, Plećaš, Bosiljka, Ignjatović, Svetlana, "Oxytocin affects changes in behaviour, BDNF and Ki-67 expression in hippocampus, caused by chronic corticosterone treatment" in European Neuropsychopharmacology, 26, no. Supplement 2 (2016):S289-S289,
https://doi.org/10.1016/S0924-977X(16)31184-1 . .

TY  - JOUR
AU  - Petrović, Jelena
AU  - Pešić, Vesna
AU  - Popović, Dejana
AU  - Plećaš, Bosiljka
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2271
AB  - Magnesium has a fundamental role in human body and it is necessary for many processes such as: transmembrane ion flux, neuronal activity, neurotransmitter release, regulation of adenylate cyclase and hormone receptor binding. In the central nervous system magnesium blocks the activity of NMDA receptors and magnesium-deficiency leads to NMDA receptors overactivity, possibly causing neuronal injury and neurological dysfunction, which consequently may manifest as major depression. Numerous pre-clinical and clinical studies confirmed that magnesium influences several systems associated with development of depression. On the other hand, standard antidepressants are ineffective in 40% of cases, and have some unpleasant side-effects. Even though the first positive effect of magnesium in patients with agitated depression was reported in 1921, unfortunately, only small number of studies that favor magnesium's effectiveness in treating depression was published in past decades, including one randomized clinical trial in which magnesium was as effective as imipramine in depressed elderly patients that suffered from diabetes. Even though much more clinical research is needed to extend this important line of research and to confirm its efficacy, due to its safety magnesium preparations could be considered as a potential addition for treatment resistant depression cases.
AB  - Magnezijum ima značajnu fiziološku ulogu u humanom organizmu i neophodan je za mnoge procese, uključujući: transmembransko kretanje jona, aktivnost neurona, oslobađanje neurotransmitera, regulaciju adenilat ciklaze i vezivanje pojedinih hormona za receptore. U centralnom nervnom sistemu magnezijum blokira aktivnost NMDA receptora, a deficit magnezijuma dovodi do prekomerne aktivacije NMDA receptora, što za posledicu može imati oštećenja neurona i neurološke disfunkcije i u krajnjoj liniji, može se manifestovati razvojem velike depresije. Brojna pretklinička i klinička ispitivanja potvrđuju da magnezijum utiče na nekoliko sistema uključenih u razvoj depresije. Sa druge strane, oko 40% pacijenata pokazuje rezistenciju na tretman standardnim antidepresivima, kojima se pripisuju i brojni neprijatni neželjeni efekti. Iako je prvi pozitivan učinak magnezijuma kod pacijenata koji pate od agitirane depresije prikazan još 1921, nažalost, samo mali broj studija koje govore u prilog efikasnosti magnezijuma u tretmanu depresije je publikovan tokom proteklih decenija, uključujući jedno randomizovano kliničko ispitivanje koje je pokazalo podjednaku efikasnost magnezijuma i imipramina kod starijih depresivnih pacijenata koji boluju od dijabetesa. Iako je neophodno sprovesti veći broj kliničkih ispitivanja i proširiti ovo polje istraživanja u cilju potvrđivanja njegove efikasnosti, usled svoje bezbednosti, magnezijum bi se potencijalno mogao uvesti kao dodatni tretman u lečenju depresije rezistentne na terapiju.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Role of magnesium in depression?
T1  - Uloga magnezijuma u depresiji?
VL  - 64
IS  - 4
SP  - 322
EP  - 334
DO  - 10.5937/arhfarm1404322P
ER  - 

@article{
author = "Petrović, Jelena and Pešić, Vesna and Popović, Dejana and Plećaš, Bosiljka",
year = "2014",
abstract = "Magnesium has a fundamental role in human body and it is necessary for many processes such as: transmembrane ion flux, neuronal activity, neurotransmitter release, regulation of adenylate cyclase and hormone receptor binding. In the central nervous system magnesium blocks the activity of NMDA receptors and magnesium-deficiency leads to NMDA receptors overactivity, possibly causing neuronal injury and neurological dysfunction, which consequently may manifest as major depression. Numerous pre-clinical and clinical studies confirmed that magnesium influences several systems associated with development of depression. On the other hand, standard antidepressants are ineffective in 40% of cases, and have some unpleasant side-effects. Even though the first positive effect of magnesium in patients with agitated depression was reported in 1921, unfortunately, only small number of studies that favor magnesium's effectiveness in treating depression was published in past decades, including one randomized clinical trial in which magnesium was as effective as imipramine in depressed elderly patients that suffered from diabetes. Even though much more clinical research is needed to extend this important line of research and to confirm its efficacy, due to its safety magnesium preparations could be considered as a potential addition for treatment resistant depression cases., Magnezijum ima značajnu fiziološku ulogu u humanom organizmu i neophodan je za mnoge procese, uključujući: transmembransko kretanje jona, aktivnost neurona, oslobađanje neurotransmitera, regulaciju adenilat ciklaze i vezivanje pojedinih hormona za receptore. U centralnom nervnom sistemu magnezijum blokira aktivnost NMDA receptora, a deficit magnezijuma dovodi do prekomerne aktivacije NMDA receptora, što za posledicu može imati oštećenja neurona i neurološke disfunkcije i u krajnjoj liniji, može se manifestovati razvojem velike depresije. Brojna pretklinička i klinička ispitivanja potvrđuju da magnezijum utiče na nekoliko sistema uključenih u razvoj depresije. Sa druge strane, oko 40% pacijenata pokazuje rezistenciju na tretman standardnim antidepresivima, kojima se pripisuju i brojni neprijatni neželjeni efekti. Iako je prvi pozitivan učinak magnezijuma kod pacijenata koji pate od agitirane depresije prikazan još 1921, nažalost, samo mali broj studija koje govore u prilog efikasnosti magnezijuma u tretmanu depresije je publikovan tokom proteklih decenija, uključujući jedno randomizovano kliničko ispitivanje koje je pokazalo podjednaku efikasnost magnezijuma i imipramina kod starijih depresivnih pacijenata koji boluju od dijabetesa. Iako je neophodno sprovesti veći broj kliničkih ispitivanja i proširiti ovo polje istraživanja u cilju potvrđivanja njegove efikasnosti, usled svoje bezbednosti, magnezijum bi se potencijalno mogao uvesti kao dodatni tretman u lečenju depresije rezistentne na terapiju.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Role of magnesium in depression?, Uloga magnezijuma u depresiji?",
volume = "64",
number = "4",
pages = "322-334",
doi = "10.5937/arhfarm1404322P"
}

Petrović, J., Pešić, V., Popović, D.,& Plećaš, B.. (2014). Role of magnesium in depression?. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 64(4), 322-334.
https://doi.org/10.5937/arhfarm1404322P

Petrović J, Pešić V, Popović D, Plećaš B. Role of magnesium in depression?. in Arhiv za farmaciju. 2014;64(4):322-334.
doi:10.5937/arhfarm1404322P .

Petrović, Jelena, Pešić, Vesna, Popović, Dejana, Plećaš, Bosiljka, "Role of magnesium in depression?" in Arhiv za farmaciju, 64, no. 4 (2014):322-334,
https://doi.org/10.5937/arhfarm1404322P . .

TY  - JOUR
AU  - Zogović, Dušanka
AU  - Pešić, Vesna
AU  - Dmitrasinović, Gordana
AU  - Dajak, Marijana
AU  - Plećaš, Bosiljka
AU  - Batinić, Bojan
AU  - Popović, Dejana
AU  - Ignjatović, Svetlana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2237
AB  - Background: Sleep deprivation, malnutrition and lack of physical activity are contemporary stress-related factors present in the student population. Stress activates the HPA and often suppresses the HPG axis, but also influences cytokine synthesis and consequently regulates immune response. Since magnesium deficiency facilitates negative pathophysiological consequences, a reasonable question imposes, wheth er Mg supplementation might correct the adrenal/go nadal hormone balance and immuno-endocrine function. Methods: Fifteen male students were given 2 x 250 mg Mg for four weeks. Serum levels of FSH, LH, testosterone (T), ACTH and cortisol
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students
VL  - 33
IS  - 3
SP  - 291
EP  - 298
DO  - 10.2478/jomb-2014-0016
ER  - 

@article{
author = "Zogović, Dušanka and Pešić, Vesna and Dmitrasinović, Gordana and Dajak, Marijana and Plećaš, Bosiljka and Batinić, Bojan and Popović, Dejana and Ignjatović, Svetlana",
year = "2014",
abstract = "Background: Sleep deprivation, malnutrition and lack of physical activity are contemporary stress-related factors present in the student population. Stress activates the HPA and often suppresses the HPG axis, but also influences cytokine synthesis and consequently regulates immune response. Since magnesium deficiency facilitates negative pathophysiological consequences, a reasonable question imposes, wheth er Mg supplementation might correct the adrenal/go nadal hormone balance and immuno-endocrine function. Methods: Fifteen male students were given 2 x 250 mg Mg for four weeks. Serum levels of FSH, LH, testosterone (T), ACTH and cortisol",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students",
volume = "33",
number = "3",
pages = "291-298",
doi = "10.2478/jomb-2014-0016"
}

Zogović, D., Pešić, V., Dmitrasinović, G., Dajak, M., Plećaš, B., Batinić, B., Popović, D.,& Ignjatović, S.. (2014). Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 33(3), 291-298.
https://doi.org/10.2478/jomb-2014-0016

Zogović D, Pešić V, Dmitrasinović G, Dajak M, Plećaš B, Batinić B, Popović D, Ignjatović S. Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students. in Journal of Medical Biochemistry. 2014;33(3):291-298.
doi:10.2478/jomb-2014-0016 .

Zogović, Dušanka, Pešić, Vesna, Dmitrasinović, Gordana, Dajak, Marijana, Plećaš, Bosiljka, Batinić, Bojan, Popović, Dejana, Ignjatović, Svetlana, "Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students" in Journal of Medical Biochemistry, 33, no. 3 (2014):291-298,
https://doi.org/10.2478/jomb-2014-0016 . .

TY  - JOUR
AU  - Pešić, Vesna
AU  - Zogović, Dušanka
AU  - Spremo-Potparević, Biljana
AU  - Plećaš, Bosiljka
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1606
AB  - In this paper we described the homeostasis of elementary iron: its absorption, utilization, storage and elimination. Special attention was paid to new insights into the regulatory mechanisams involved in its homestasis, especially the role of recently discovered hormone hepcidin, which is synthesized in the liver. Since it is reckoned that hepcidin has a central role in the systemic regulation of iron metabolism, the influences of various factors and conditions on the hepatic synthesis of hepcidin were delineated. Furthermore, we briefly described the most common disorders of iron homeostasis and their possible involvement in the pathogenesis of some diseases.
AB  - U radu je opisan promet gvožđa u organizmu: unošenje, iskorišćavanje, deponovanje i eliminacija. Posebna pažnja posvećena je novim saznanjima o regulaciji prometa tog elementa neophodnog za život. U tom smislu je istaknut, relativno skoro otkriven, hormon hepcidin koji sintetišu hepatociti. Smatra se da hepcidin zauzima centralno mesto u sistemskoj regulaciji metabolizma gvožđa i prikazan je uticaj različitih faktora i stanja na sintezu hepcidina u jetri. Ukratko su opisani i najčešći poremećaji homeostaze gvožđa i njegova eventualna uloga u patogenezi nekih oboljenja.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Iron homeostasis
T1  - Homeostaza gvožđa
VL  - 61
IS  - 1
SP  - 42
EP  - 64
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1606
ER  - 

@article{
author = "Pešić, Vesna and Zogović, Dušanka and Spremo-Potparević, Biljana and Plećaš, Bosiljka",
year = "2011",
abstract = "In this paper we described the homeostasis of elementary iron: its absorption, utilization, storage and elimination. Special attention was paid to new insights into the regulatory mechanisams involved in its homestasis, especially the role of recently discovered hormone hepcidin, which is synthesized in the liver. Since it is reckoned that hepcidin has a central role in the systemic regulation of iron metabolism, the influences of various factors and conditions on the hepatic synthesis of hepcidin were delineated. Furthermore, we briefly described the most common disorders of iron homeostasis and their possible involvement in the pathogenesis of some diseases., U radu je opisan promet gvožđa u organizmu: unošenje, iskorišćavanje, deponovanje i eliminacija. Posebna pažnja posvećena je novim saznanjima o regulaciji prometa tog elementa neophodnog za život. U tom smislu je istaknut, relativno skoro otkriven, hormon hepcidin koji sintetišu hepatociti. Smatra se da hepcidin zauzima centralno mesto u sistemskoj regulaciji metabolizma gvožđa i prikazan je uticaj različitih faktora i stanja na sintezu hepcidina u jetri. Ukratko su opisani i najčešći poremećaji homeostaze gvožđa i njegova eventualna uloga u patogenezi nekih oboljenja.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Iron homeostasis, Homeostaza gvožđa",
volume = "61",
number = "1",
pages = "42-64",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1606"
}

Pešić, V., Zogović, D., Spremo-Potparević, B.,& Plećaš, B.. (2011). Iron homeostasis. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 61(1), 42-64.
https://hdl.handle.net/21.15107/rcub_farfar_1606

Pešić V, Zogović D, Spremo-Potparević B, Plećaš B. Iron homeostasis. in Arhiv za farmaciju. 2011;61(1):42-64.
https://hdl.handle.net/21.15107/rcub_farfar_1606 .

Pešić, Vesna, Zogović, Dušanka, Spremo-Potparević, Biljana, Plećaš, Bosiljka, "Iron homeostasis" in Arhiv za farmaciju, 61, no. 1 (2011):42-64,
https://hdl.handle.net/21.15107/rcub_farfar_1606 .

TY  - JOUR
AU  - Živković, Lada
AU  - Plećaš, Bosiljka
AU  - Bajić, Vladan
AU  - Đelić, Ninoslav
AU  - Spremo-Potparević, Biljana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1605
AB  - DNA damage is a powerful trigger of apoptosis in neurons and is present in patients with Alzheimer's disease (AB). Also, DNA damage is registered in cells that are not neurons, such as peripheral blood leukocytes and fibroblasts. In this paper we examined and compared the impact of AB and chronological aging on DNA damage in peripheral blood leukocytes. We used electrophoresis of individual cells on gel (comet test) as a modern and reliable method for registration of nuclear DNA damage whose fragments form a comet tail, which is not present in undamaged cells. We analyzed leukocytes of these groups: AB patients with sporadic form of the disease, healthy elderly of an appropriate age and healthy younger adults as controls. The results show that the frequency of AB patients with leukocyte DNA damage significantly is higher than in similar control age-matched controls. Also, a significant increase in the frequency of DNA damage has been observed during chronological aging. Based on the obtained data we can conclude that genetic instability, otherwise present in the elderly is more expressed in patients with sporadic AB, which indicates that it is not just an epiphenomenon of aging, but is characteristic of the disease.
AB  - Oštećenja DNK su snažan okidač apoptoze neurona i prisutna su kod obolelih od Alchajmerove bolesti (AB). Ona se registruju i u ćelijama koje nisu neuroni, kao što su leukociti periferne krvi i fibroblasti. U ovom radu smo ispitivali i poredili uticaj AB i hronološkog starenja na oštećenje DNK leukocita periferne krvi. Koristili smo elektroforezu pojedinačnih ćelija na gelu (Komet test), kao savremenu i pouzdanu metodu za registrovanje oštećenja jedarne DNK čiji fragmenti formiraju rep komete, koji nije prisutan u neoštećenim ćelijama. Analizarani su leukociti: AB pacijenata sa sporadičnim oblikom bolesti, zdravih starih osoba odgovarajuće starosti i zdravih odraslih mlađih kontrolnih osoba. Dobijeni rezultati pokazuju da je kod AB ispitanika frekvencija leukocita sa oštećenjima DNK statistički značajno veća nego kod kontrola slične starosti; značajan porast učestalosti oštećenja DNK zapaža se i tokom hronološkog starenja. Na osnovu dobijenih podataka možemo da zaključimo da je genetička nestabilnost, inače prisutna i kod starih osoba, jače izražena kod pacijenata sa sporadičnom AB, što ukazuje na to da ona nije samo epifenomen starenja, već je karakteristika same bolesti.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Evaluation of DNA damages in peripheral blood leukocytes of Alzheimer's disease patients by Comet test
T1  - Ispitivanje stepena oštećenja DNK leukocita periferne krvi pacijenata sa Alchajmerovom bolešću primenom Komet testa
VL  - 61
IS  - 1
SP  - 28
EP  - 41
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_795
ER  - 

@article{
author = "Živković, Lada and Plećaš, Bosiljka and Bajić, Vladan and Đelić, Ninoslav and Spremo-Potparević, Biljana",
year = "2011",
abstract = "DNA damage is a powerful trigger of apoptosis in neurons and is present in patients with Alzheimer's disease (AB). Also, DNA damage is registered in cells that are not neurons, such as peripheral blood leukocytes and fibroblasts. In this paper we examined and compared the impact of AB and chronological aging on DNA damage in peripheral blood leukocytes. We used electrophoresis of individual cells on gel (comet test) as a modern and reliable method for registration of nuclear DNA damage whose fragments form a comet tail, which is not present in undamaged cells. We analyzed leukocytes of these groups: AB patients with sporadic form of the disease, healthy elderly of an appropriate age and healthy younger adults as controls. The results show that the frequency of AB patients with leukocyte DNA damage significantly is higher than in similar control age-matched controls. Also, a significant increase in the frequency of DNA damage has been observed during chronological aging. Based on the obtained data we can conclude that genetic instability, otherwise present in the elderly is more expressed in patients with sporadic AB, which indicates that it is not just an epiphenomenon of aging, but is characteristic of the disease., Oštećenja DNK su snažan okidač apoptoze neurona i prisutna su kod obolelih od Alchajmerove bolesti (AB). Ona se registruju i u ćelijama koje nisu neuroni, kao što su leukociti periferne krvi i fibroblasti. U ovom radu smo ispitivali i poredili uticaj AB i hronološkog starenja na oštećenje DNK leukocita periferne krvi. Koristili smo elektroforezu pojedinačnih ćelija na gelu (Komet test), kao savremenu i pouzdanu metodu za registrovanje oštećenja jedarne DNK čiji fragmenti formiraju rep komete, koji nije prisutan u neoštećenim ćelijama. Analizarani su leukociti: AB pacijenata sa sporadičnim oblikom bolesti, zdravih starih osoba odgovarajuće starosti i zdravih odraslih mlađih kontrolnih osoba. Dobijeni rezultati pokazuju da je kod AB ispitanika frekvencija leukocita sa oštećenjima DNK statistički značajno veća nego kod kontrola slične starosti; značajan porast učestalosti oštećenja DNK zapaža se i tokom hronološkog starenja. Na osnovu dobijenih podataka možemo da zaključimo da je genetička nestabilnost, inače prisutna i kod starih osoba, jače izražena kod pacijenata sa sporadičnom AB, što ukazuje na to da ona nije samo epifenomen starenja, već je karakteristika same bolesti.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Evaluation of DNA damages in peripheral blood leukocytes of Alzheimer's disease patients by Comet test, Ispitivanje stepena oštećenja DNK leukocita periferne krvi pacijenata sa Alchajmerovom bolešću primenom Komet testa",
volume = "61",
number = "1",
pages = "28-41",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_795"
}

Živković, L., Plećaš, B., Bajić, V., Đelić, N.,& Spremo-Potparević, B.. (2011). Evaluation of DNA damages in peripheral blood leukocytes of Alzheimer's disease patients by Comet test. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 61(1), 28-41.
https://hdl.handle.net/21.15107/rcub_veterinar_795

Živković L, Plećaš B, Bajić V, Đelić N, Spremo-Potparević B. Evaluation of DNA damages in peripheral blood leukocytes of Alzheimer's disease patients by Comet test. in Arhiv za farmaciju. 2011;61(1):28-41.
https://hdl.handle.net/21.15107/rcub_veterinar_795 .

Živković, Lada, Plećaš, Bosiljka, Bajić, Vladan, Đelić, Ninoslav, Spremo-Potparević, Biljana, "Evaluation of DNA damages in peripheral blood leukocytes of Alzheimer's disease patients by Comet test" in Arhiv za farmaciju, 61, no. 1 (2011):28-41,
https://hdl.handle.net/21.15107/rcub_veterinar_795 .

TY  - JOUR
AU  - Plećaš, Bosiljka
AU  - Živković, Lada
AU  - Potparević, Biljana
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1324
AB  - Aging is inevitable, and as the percentage of elderly in the population increases it becomes more important to understand physiological mechanisms associated with the normal aging process so the quality of life can be sustained. Maintaining physiological functions or 'health' in aging population will help to reduce the burden on the medical systems. In this work, we briefly consider, in the light of up-to-date scientific data and hypotheses, some key questions on the biology and physiology of aging: what is it and why does it happen. Prospects for delaying and impeding the aging process are disputed as well.
AB  - Starenje je neizbežno i kako zastupljenost starih osoba u populaciji raste, razumevanje fizioloških mehanizama uključenih u proces normalnog starenja ima sve veći značaj u cilju održavanja kvaliteta života u starosti. Takođe, očuvanje fizioloških funkcija ili 'zdravlja' starih ljudi smanjiće pritisak na zdravstvene sisteme i troškove. U ovom radu, u svetlu najnovijih naučnih podataka i hipoteza, sažeto se razmatraju neka ključna pitanja u vezi biologije i fiziologije starenja: šta je starenje i zašto se ono događa, kao i mogućnosti odlaganja i usporavanja starenja.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - The biology and physiology of aging
T1  - Biologija i fiziologija starenja
VL  - 59
IS  - 5
SP  - 357
EP  - 372
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1324
ER  - 

@article{
author = "Plećaš, Bosiljka and Živković, Lada and Potparević, Biljana",
year = "2009",
abstract = "Aging is inevitable, and as the percentage of elderly in the population increases it becomes more important to understand physiological mechanisms associated with the normal aging process so the quality of life can be sustained. Maintaining physiological functions or 'health' in aging population will help to reduce the burden on the medical systems. In this work, we briefly consider, in the light of up-to-date scientific data and hypotheses, some key questions on the biology and physiology of aging: what is it and why does it happen. Prospects for delaying and impeding the aging process are disputed as well., Starenje je neizbežno i kako zastupljenost starih osoba u populaciji raste, razumevanje fizioloških mehanizama uključenih u proces normalnog starenja ima sve veći značaj u cilju održavanja kvaliteta života u starosti. Takođe, očuvanje fizioloških funkcija ili 'zdravlja' starih ljudi smanjiće pritisak na zdravstvene sisteme i troškove. U ovom radu, u svetlu najnovijih naučnih podataka i hipoteza, sažeto se razmatraju neka ključna pitanja u vezi biologije i fiziologije starenja: šta je starenje i zašto se ono događa, kao i mogućnosti odlaganja i usporavanja starenja.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "The biology and physiology of aging, Biologija i fiziologija starenja",
volume = "59",
number = "5",
pages = "357-372",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1324"
}

Plećaš, B., Živković, L.,& Potparević, B.. (2009). The biology and physiology of aging. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 59(5), 357-372.
https://hdl.handle.net/21.15107/rcub_farfar_1324

Plećaš B, Živković L, Potparević B. The biology and physiology of aging. in Arhiv za farmaciju. 2009;59(5):357-372.
https://hdl.handle.net/21.15107/rcub_farfar_1324 .

Plećaš, Bosiljka, Živković, Lada, Potparević, Biljana, "The biology and physiology of aging" in Arhiv za farmaciju, 59, no. 5 (2009):357-372,
https://hdl.handle.net/21.15107/rcub_farfar_1324 .

TY  - JOUR
AU  - Leposavić, Gordana
AU  - Plećaš, Bosiljka
AU  - Kosec, Duško
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/253
AB  - To elucidate a putative role of beta-adrenoceptors in the modulation of intrathymic T-cell maturation, the expression of major differentiational antigene (CD4/CD8 and TCR alpha beta) on the thymocytes from both immature (aged 21 day at the beginning of the treatment) and adult (a,oed 75 days at the beginning of treatment) male rats subjected to a 15-day-long propranolol treatment (0.40 mg/100 g/day, s.c.) was analyzed by two- and one-color flow cytometry, respectively. Rats of matched age injected with saline served as controls. The propranolol treatment in immature but not adult rats caused a significant reduction in both the relative thymus weight and total thymocyte yield. In addition, a significant increase in the percentage of CD4(+)8(+) double-positive cells, with a proportional decrease in the relative proportion of CD4(+)8(-) single positive cells, was found in immature rats. In contrast, a slight but significant decrease in the percentage of CD4(+)8(+) cells with a parallel increase in the relative proportion of CD4+8- cells was found in adult rats. In both groups of rats, the percentage of TCR alpha beta(total) thymocytes was increased: in immature rats this was due to an increase in the percentage of TCR alpha beta(low) thymocytes, while in the adult rats it reflected a rise in the relative proportion of TCR alpha beta(high) cells. In conclusion, the study revealed that propranolol treatment in both immature and adult rats alters the relative proportion of CD4(+)8(+) and CD4(+)8(-) thymocytes, but in opposite fashion, and the data suggest that this treatment affects distinct fractions within the population of CD4(+)8(+) thymocytes with respect to expression of TCR alpha beta. The results also indicate that, regardless of rat sexual maturity, the development of thymocytes towards CD4(-)8(+) T-cells is relatively insensitive to long-lasting P-adrenoceptor blockade.
PB  - Elsevier Science BV, Amsterdam
T2  - Immunopharmacology
T1  - Differential effects of chronic propranolol treatment on the phenotypic profile of thymocytes from immature and adult rats
VL  - 46
IS  - 1
SP  - 79
EP  - 87
DO  - 10.1016/S0162-3109(99)00160-5
ER  - 

@article{
author = "Leposavić, Gordana and Plećaš, Bosiljka and Kosec, Duško",
year = "2000",
abstract = "To elucidate a putative role of beta-adrenoceptors in the modulation of intrathymic T-cell maturation, the expression of major differentiational antigene (CD4/CD8 and TCR alpha beta) on the thymocytes from both immature (aged 21 day at the beginning of the treatment) and adult (a,oed 75 days at the beginning of treatment) male rats subjected to a 15-day-long propranolol treatment (0.40 mg/100 g/day, s.c.) was analyzed by two- and one-color flow cytometry, respectively. Rats of matched age injected with saline served as controls. The propranolol treatment in immature but not adult rats caused a significant reduction in both the relative thymus weight and total thymocyte yield. In addition, a significant increase in the percentage of CD4(+)8(+) double-positive cells, with a proportional decrease in the relative proportion of CD4(+)8(-) single positive cells, was found in immature rats. In contrast, a slight but significant decrease in the percentage of CD4(+)8(+) cells with a parallel increase in the relative proportion of CD4+8- cells was found in adult rats. In both groups of rats, the percentage of TCR alpha beta(total) thymocytes was increased: in immature rats this was due to an increase in the percentage of TCR alpha beta(low) thymocytes, while in the adult rats it reflected a rise in the relative proportion of TCR alpha beta(high) cells. In conclusion, the study revealed that propranolol treatment in both immature and adult rats alters the relative proportion of CD4(+)8(+) and CD4(+)8(-) thymocytes, but in opposite fashion, and the data suggest that this treatment affects distinct fractions within the population of CD4(+)8(+) thymocytes with respect to expression of TCR alpha beta. The results also indicate that, regardless of rat sexual maturity, the development of thymocytes towards CD4(-)8(+) T-cells is relatively insensitive to long-lasting P-adrenoceptor blockade.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Immunopharmacology",
title = "Differential effects of chronic propranolol treatment on the phenotypic profile of thymocytes from immature and adult rats",
volume = "46",
number = "1",
pages = "79-87",
doi = "10.1016/S0162-3109(99)00160-5"
}

Leposavić, G., Plećaš, B.,& Kosec, D.. (2000). Differential effects of chronic propranolol treatment on the phenotypic profile of thymocytes from immature and adult rats. in Immunopharmacology
Elsevier Science BV, Amsterdam., 46(1), 79-87.
https://doi.org/10.1016/S0162-3109(99)00160-5

Leposavić G, Plećaš B, Kosec D. Differential effects of chronic propranolol treatment on the phenotypic profile of thymocytes from immature and adult rats. in Immunopharmacology. 2000;46(1):79-87.
doi:10.1016/S0162-3109(99)00160-5 .

Leposavić, Gordana, Plećaš, Bosiljka, Kosec, Duško, "Differential effects of chronic propranolol treatment on the phenotypic profile of thymocytes from immature and adult rats" in Immunopharmacology, 46, no. 1 (2000):79-87,
https://doi.org/10.1016/S0162-3109(99)00160-5 . .

TY  - CONF
AU  - Leposavić, Gordana
AU  - Plećaš, Bosiljka
AU  - Kosec, Duško
PY  - 1998
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/188
PB  - Blackwell Science Ltd, Oxford
C3  - European Journal of Neuroscience
T1  - Differential effects of a-adrenoceptor blockade on the intrathymic thymocytes maturation in adult and peripubertal rats
VL  - 10
SP  - 295
EP  - 295
UR  - https://hdl.handle.net/21.15107/rcub_farfar_188
ER  - 

@conference{
author = "Leposavić, Gordana and Plećaš, Bosiljka and Kosec, Duško",
year = "1998",
publisher = "Blackwell Science Ltd, Oxford",
journal = "European Journal of Neuroscience",
title = "Differential effects of a-adrenoceptor blockade on the intrathymic thymocytes maturation in adult and peripubertal rats",
volume = "10",
pages = "295-295",
url = "https://hdl.handle.net/21.15107/rcub_farfar_188"
}

Leposavić, G., Plećaš, B.,& Kosec, D.. (1998). Differential effects of a-adrenoceptor blockade on the intrathymic thymocytes maturation in adult and peripubertal rats. in European Journal of Neuroscience
Blackwell Science Ltd, Oxford., 10, 295-295.
https://hdl.handle.net/21.15107/rcub_farfar_188

Leposavić G, Plećaš B, Kosec D. Differential effects of a-adrenoceptor blockade on the intrathymic thymocytes maturation in adult and peripubertal rats. in European Journal of Neuroscience. 1998;10:295-295.
https://hdl.handle.net/21.15107/rcub_farfar_188 .

Leposavić, Gordana, Plećaš, Bosiljka, Kosec, Duško, "Differential effects of a-adrenoceptor blockade on the intrathymic thymocytes maturation in adult and peripubertal rats" in European Journal of Neuroscience, 10 (1998):295-295,
https://hdl.handle.net/21.15107/rcub_farfar_188 .