TY  - JOUR
AU  - Durić, Vedrana
AU  - Batinić, Bojan
AU  - Petrović, Jelena
AU  - Stanić, Dušanka
AU  - Bulat, Zorica
AU  - Pešić, Vesna
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3172
AB  - Although a magnesium-mediated attenuation of memory deficits was reported in animal models of ageing and traumatic brain injury, a possible memory enhancement in healthy subjects has not been investigated yet. We used novel object recognition test (NORT) to examine the effects of acute (30 mg/kg) and chronic (50 mg/kg, 28 days) Mg-sulfate treatment on the long-term memory (LTM) in healthy adult male rats, and to test the sustainability of magnesium effects in the models of acute and chronic (21 days) ACTH administration (10 mu g/animal), mimicking the stress- and depression-like conditions. A single dose of Mg-sulfate enhanced the LTM retrieval in the 24 h inter-trial NORT protocol, in healthy, as well as in rats acutely treated with ACTH. Memory enhancement was also detected after 4-week long Mg-sulfate intake, in both healthy and rats chronically treated with ACTH. While the present findings on procognitive effects of chronic Mg-sulfate treatment corroborate with those from studies on the therapeutic potential of Mg-threonate, the current study is the first to report on memory enhancement induced by a single dose of magnesium.
PB  - John Libbey Eurotext Ltd, Montrouge
T2  - Magnesium Research
T1  - A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats
VL  - 31
IS  - 1
SP  - 24
EP  - 32
DO  - 10.1684/mrh.2018.0435
ER  - 

@article{
author = "Durić, Vedrana and Batinić, Bojan and Petrović, Jelena and Stanić, Dušanka and Bulat, Zorica and Pešić, Vesna",
year = "2018",
abstract = "Although a magnesium-mediated attenuation of memory deficits was reported in animal models of ageing and traumatic brain injury, a possible memory enhancement in healthy subjects has not been investigated yet. We used novel object recognition test (NORT) to examine the effects of acute (30 mg/kg) and chronic (50 mg/kg, 28 days) Mg-sulfate treatment on the long-term memory (LTM) in healthy adult male rats, and to test the sustainability of magnesium effects in the models of acute and chronic (21 days) ACTH administration (10 mu g/animal), mimicking the stress- and depression-like conditions. A single dose of Mg-sulfate enhanced the LTM retrieval in the 24 h inter-trial NORT protocol, in healthy, as well as in rats acutely treated with ACTH. Memory enhancement was also detected after 4-week long Mg-sulfate intake, in both healthy and rats chronically treated with ACTH. While the present findings on procognitive effects of chronic Mg-sulfate treatment corroborate with those from studies on the therapeutic potential of Mg-threonate, the current study is the first to report on memory enhancement induced by a single dose of magnesium.",
publisher = "John Libbey Eurotext Ltd, Montrouge",
journal = "Magnesium Research",
title = "A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats",
volume = "31",
number = "1",
pages = "24-32",
doi = "10.1684/mrh.2018.0435"
}

Durić, V., Batinić, B., Petrović, J., Stanić, D., Bulat, Z.,& Pešić, V.. (2018). A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats. in Magnesium Research
John Libbey Eurotext Ltd, Montrouge., 31(1), 24-32.
https://doi.org/10.1684/mrh.2018.0435

Durić V, Batinić B, Petrović J, Stanić D, Bulat Z, Pešić V. A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats. in Magnesium Research. 2018;31(1):24-32.
doi:10.1684/mrh.2018.0435 .

Durić, Vedrana, Batinić, Bojan, Petrović, Jelena, Stanić, Dušanka, Bulat, Zorica, Pešić, Vesna, "A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats" in Magnesium Research, 31, no. 1 (2018):24-32,
https://doi.org/10.1684/mrh.2018.0435 . .