TY  - JOUR
AU  - Miljević, Čedo D.
AU  - Nikolić-Kokić, Aleksandra
AU  - Blagojević, Duško
AU  - Milovanović, Maja
AU  - Munjiza, Ana
AU  - Jukić, Marin
AU  - Pešić, Vesna
AU  - Lecić-Tosevski, Dušica
AU  - Spasić, Mihajlo B.
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3058
AB  - To determine the relationship between alterations in the activity of the enzymes participating in antioxidative defense system and neurological soft signs (NSS) in schizophrenic patients with the first episode psychosis (S-FE, n = 19), patients in relapse (S-R, n = 46), and healthy controls (HC, n = 20). NSS intensity and enzymatic plasma activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) were compared between S-FE, S-R and HC subjects and a follow-up correlation analyses between the enzyme activities and NSS intensity was performed. NSS intensity was increased four times in schizophrenic patients compared with healthy controls. Activities of SOD and CAT were 40% decreased in S-FE and these reductions were ameliorated by antipsychotic treatment. GPX activity was 20% decreased in both patient groups compared with controls. A negative correlation between NSS intensity and GPX activity was specifically found in the S-FE patients. The data in this report argue that a reduction of GPX activity might be one of the causes for the emergence of NSS at the onset of schizophrenia, and provide the evidence that antipsychotic therapy can attenuate activity reductions of SOD and CAT, but not the activity reduction of GPX and the intensity of NSS.
PB  - Elsevier Ireland Ltd, Clare
T2  - Psychoneuroendocrinology
T1  - Association between neurological soft signs and antioxidant enzyme activity in schizophrenic patients
VL  - 269
SP  - 746
EP  - 752
DO  - 10.1016/j.psychres.2018.09.009
ER  - 

@article{
author = "Miljević, Čedo D. and Nikolić-Kokić, Aleksandra and Blagojević, Duško and Milovanović, Maja and Munjiza, Ana and Jukić, Marin and Pešić, Vesna and Lecić-Tosevski, Dušica and Spasić, Mihajlo B.",
year = "2018",
abstract = "To determine the relationship between alterations in the activity of the enzymes participating in antioxidative defense system and neurological soft signs (NSS) in schizophrenic patients with the first episode psychosis (S-FE, n = 19), patients in relapse (S-R, n = 46), and healthy controls (HC, n = 20). NSS intensity and enzymatic plasma activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) were compared between S-FE, S-R and HC subjects and a follow-up correlation analyses between the enzyme activities and NSS intensity was performed. NSS intensity was increased four times in schizophrenic patients compared with healthy controls. Activities of SOD and CAT were 40% decreased in S-FE and these reductions were ameliorated by antipsychotic treatment. GPX activity was 20% decreased in both patient groups compared with controls. A negative correlation between NSS intensity and GPX activity was specifically found in the S-FE patients. The data in this report argue that a reduction of GPX activity might be one of the causes for the emergence of NSS at the onset of schizophrenia, and provide the evidence that antipsychotic therapy can attenuate activity reductions of SOD and CAT, but not the activity reduction of GPX and the intensity of NSS.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Psychoneuroendocrinology",
title = "Association between neurological soft signs and antioxidant enzyme activity in schizophrenic patients",
volume = "269",
pages = "746-752",
doi = "10.1016/j.psychres.2018.09.009"
}

Miljević, Č. D., Nikolić-Kokić, A., Blagojević, D., Milovanović, M., Munjiza, A., Jukić, M., Pešić, V., Lecić-Tosevski, D.,& Spasić, M. B.. (2018). Association between neurological soft signs and antioxidant enzyme activity in schizophrenic patients. in Psychoneuroendocrinology
Elsevier Ireland Ltd, Clare., 269, 746-752.
https://doi.org/10.1016/j.psychres.2018.09.009

Miljević ČD, Nikolić-Kokić A, Blagojević D, Milovanović M, Munjiza A, Jukić M, Pešić V, Lecić-Tosevski D, Spasić MB. Association between neurological soft signs and antioxidant enzyme activity in schizophrenic patients. in Psychoneuroendocrinology. 2018;269:746-752.
doi:10.1016/j.psychres.2018.09.009 .

Miljević, Čedo D., Nikolić-Kokić, Aleksandra, Blagojević, Duško, Milovanović, Maja, Munjiza, Ana, Jukić, Marin, Pešić, Vesna, Lecić-Tosevski, Dušica, Spasić, Mihajlo B., "Association between neurological soft signs and antioxidant enzyme activity in schizophrenic patients" in Psychoneuroendocrinology, 269 (2018):746-752,
https://doi.org/10.1016/j.psychres.2018.09.009 . .