TY  - JOUR
AU  - Dangoor, Itzhak
AU  - Stanić, Dušanka
AU  - Reshef, Leah
AU  - Pešić, Vesna
AU  - Gophna, Uri
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3965
AB  - Humans are colonized by bacteria, fungi, archaea, and viruses, which are collectively referred to as the microbiome. Most of the microbiome resides in the gut and may easily be investigated via stool sampling and subsequent metagenomic DNA sequencing. Prolonged exposure to psychiatric pharmacological agents is often associated with marked gastrointestinal phenomena, including changes in food intake, bowel motility, gastric emptying, and transit time [1–3]. Unlike the relatively objective measurement of the microbiota composition, accurate assessment of patients’ therapy adherence and treatment outcomes represent a challenge in psychiatric medical care [4]. This is partly because, for most psychopharmacological agents, compliance and response to treatments are subjectively assessed based on self-reporting and physicians’ evaluations [5,6]. An interesting alternative is having changes in the psychiatric patients’ gut microbiota composition serve as a measurable proxy for monitoring patients’ compliance and the therapeutic effects of some drugs. It is yet unclear how behavioral changes and drug intake affect the microbiota; however, mounting evidence suggests that physical and mental disturbances may lead to changes in gastrointestinal (GI) motility [7,8] in both animals and humans [9–11]. Indeed, in humans, anger, fear, pain, and anxiety, as well as intensive exercise, results in changes in GI activity [8]. In rats, chronic stress results in initial delayed gastric emptying followed by acceleration later on [12]. Medication intake [13,14] and changes in stool consistency, gastric transit, and emptying time [15,16] also have a great impact on microbial composition.
PB  - MDPI
T2  - Microorganisms
T1  - Specific changes in the mammalian gut microbiome as a biomarker for oxytocin-induced behavioral changes
VL  - 9
IS  - 9
DO  - 10.3390/microorganisms9091938
ER  - 

@article{
author = "Dangoor, Itzhak and Stanić, Dušanka and Reshef, Leah and Pešić, Vesna and Gophna, Uri",
year = "2021",
abstract = "Humans are colonized by bacteria, fungi, archaea, and viruses, which are collectively referred to as the microbiome. Most of the microbiome resides in the gut and may easily be investigated via stool sampling and subsequent metagenomic DNA sequencing. Prolonged exposure to psychiatric pharmacological agents is often associated with marked gastrointestinal phenomena, including changes in food intake, bowel motility, gastric emptying, and transit time [1–3]. Unlike the relatively objective measurement of the microbiota composition, accurate assessment of patients’ therapy adherence and treatment outcomes represent a challenge in psychiatric medical care [4]. This is partly because, for most psychopharmacological agents, compliance and response to treatments are subjectively assessed based on self-reporting and physicians’ evaluations [5,6]. An interesting alternative is having changes in the psychiatric patients’ gut microbiota composition serve as a measurable proxy for monitoring patients’ compliance and the therapeutic effects of some drugs. It is yet unclear how behavioral changes and drug intake affect the microbiota; however, mounting evidence suggests that physical and mental disturbances may lead to changes in gastrointestinal (GI) motility [7,8] in both animals and humans [9–11]. Indeed, in humans, anger, fear, pain, and anxiety, as well as intensive exercise, results in changes in GI activity [8]. In rats, chronic stress results in initial delayed gastric emptying followed by acceleration later on [12]. Medication intake [13,14] and changes in stool consistency, gastric transit, and emptying time [15,16] also have a great impact on microbial composition.",
publisher = "MDPI",
journal = "Microorganisms",
title = "Specific changes in the mammalian gut microbiome as a biomarker for oxytocin-induced behavioral changes",
volume = "9",
number = "9",
doi = "10.3390/microorganisms9091938"
}

Dangoor, I., Stanić, D., Reshef, L., Pešić, V.,& Gophna, U.. (2021). Specific changes in the mammalian gut microbiome as a biomarker for oxytocin-induced behavioral changes. in Microorganisms
MDPI., 9(9).
https://doi.org/10.3390/microorganisms9091938

Dangoor I, Stanić D, Reshef L, Pešić V, Gophna U. Specific changes in the mammalian gut microbiome as a biomarker for oxytocin-induced behavioral changes. in Microorganisms. 2021;9(9).
doi:10.3390/microorganisms9091938 .

Dangoor, Itzhak, Stanić, Dušanka, Reshef, Leah, Pešić, Vesna, Gophna, Uri, "Specific changes in the mammalian gut microbiome as a biomarker for oxytocin-induced behavioral changes" in Microorganisms, 9, no. 9 (2021),
https://doi.org/10.3390/microorganisms9091938 . .