TY  - JOUR
AU  - Ćulafić, Đorđe
AU  - Stulić, Miloš
AU  - Obrenović, Radmila
AU  - Miletić, Danijela
AU  - Mijac, Dragana
AU  - Stojković, Milica
AU  - Jovanović, Marija
AU  - Ćulafić, Milica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2213
AB  - AIM: To evaluate the clinical significance of cystatin C and renal resistive index for the determination of renal function in patients with liver cirrhosis. METHODS: We conducted a study of 63 patients with liver cirrhosis. A control group comprised of 30 age and gender-matched healthy persons. Serum cystatin C was determined in all study subjects and renal Doppler ultrasonography was made. Estimated glomerular filtration rate from serum creatinine (GFR(Cr)) and cystatin C (GFR(Cys)) was calculated. RESULTS: We confirmed significant differences in values of cystatin C between patients with different stages of liver cirrhosis according to Child-Pugh (P = 0.01), and a significant correlation with model of end stage liver disease (MELD) score (r(s) = 0.527, P  lt  0.001). More patients with decreased glomerular filtration rate were identified based on GFR(Cys) than on GFR(Cr) (P  lt  0.001). Significantly higher renal resistive index was noted in Child-Pugh C than in A (P  lt  0.001) and B stage (P = 0.001). Also, a significant correlation between renal resistive index and MELD score was observed (r(s) = 0.607, P  lt  0.001). Renal resistive index correlated significantly with cystatin C (r(s) = 0.283, P = 0.028) and showed a negative correlation with GFR(Cys) (r(s) = -0.31, P = 0.016). CONCLUSION: Cystatin C may be a more reliable marker for assessment of liver insufficiency. Additionally, cystatin C and renal resistive index represent sensitive indicators of renal dysfunction in patients with liver cirrhosis.
PB  - Baishideng Publishing Group Inc, Pleasanton
T2  - World Journal of Microbiology & Biotechnology
T1  - Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis
VL  - 20
IS  - 21
SP  - 6573
EP  - 6579
DO  - 10.3748/wjg.v20.i21.6573
ER  - 

@article{
author = "Ćulafić, Đorđe and Stulić, Miloš and Obrenović, Radmila and Miletić, Danijela and Mijac, Dragana and Stojković, Milica and Jovanović, Marija and Ćulafić, Milica",
year = "2014",
abstract = "AIM: To evaluate the clinical significance of cystatin C and renal resistive index for the determination of renal function in patients with liver cirrhosis. METHODS: We conducted a study of 63 patients with liver cirrhosis. A control group comprised of 30 age and gender-matched healthy persons. Serum cystatin C was determined in all study subjects and renal Doppler ultrasonography was made. Estimated glomerular filtration rate from serum creatinine (GFR(Cr)) and cystatin C (GFR(Cys)) was calculated. RESULTS: We confirmed significant differences in values of cystatin C between patients with different stages of liver cirrhosis according to Child-Pugh (P = 0.01), and a significant correlation with model of end stage liver disease (MELD) score (r(s) = 0.527, P  lt  0.001). More patients with decreased glomerular filtration rate were identified based on GFR(Cys) than on GFR(Cr) (P  lt  0.001). Significantly higher renal resistive index was noted in Child-Pugh C than in A (P  lt  0.001) and B stage (P = 0.001). Also, a significant correlation between renal resistive index and MELD score was observed (r(s) = 0.607, P  lt  0.001). Renal resistive index correlated significantly with cystatin C (r(s) = 0.283, P = 0.028) and showed a negative correlation with GFR(Cys) (r(s) = -0.31, P = 0.016). CONCLUSION: Cystatin C may be a more reliable marker for assessment of liver insufficiency. Additionally, cystatin C and renal resistive index represent sensitive indicators of renal dysfunction in patients with liver cirrhosis.",
publisher = "Baishideng Publishing Group Inc, Pleasanton",
journal = "World Journal of Microbiology & Biotechnology",
title = "Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis",
volume = "20",
number = "21",
pages = "6573-6579",
doi = "10.3748/wjg.v20.i21.6573"
}

Ćulafić, Đ., Stulić, M., Obrenović, R., Miletić, D., Mijac, D., Stojković, M., Jovanović, M.,& Ćulafić, M.. (2014). Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis. in World Journal of Microbiology & Biotechnology
Baishideng Publishing Group Inc, Pleasanton., 20(21), 6573-6579.
https://doi.org/10.3748/wjg.v20.i21.6573

Ćulafić Đ, Stulić M, Obrenović R, Miletić D, Mijac D, Stojković M, Jovanović M, Ćulafić M. Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis. in World Journal of Microbiology & Biotechnology. 2014;20(21):6573-6579.
doi:10.3748/wjg.v20.i21.6573 .

Ćulafić, Đorđe, Stulić, Miloš, Obrenović, Radmila, Miletić, Danijela, Mijac, Dragana, Stojković, Milica, Jovanović, Marija, Ćulafić, Milica, "Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis" in World Journal of Microbiology & Biotechnology, 20, no. 21 (2014):6573-6579,
https://doi.org/10.3748/wjg.v20.i21.6573 . .