TY  - JOUR
AU  - Culafić-Vojinović, Violeta
AU  - Ćulafić, Đorđe
AU  - Ignjatović, Svetlana
AU  - Petakov, Milan
AU  - Đurović-Nikolić, Marina
AU  - Vasić, Jelena
AU  - Mirković, Duško
AU  - Mijac, Dragana
AU  - Stulić, Miloš
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2146
AB  - Background: Metabolic bone disease in patients with chronic liver disease is called hepatic osteodystrophy and is primarily a sequel to osteopenia/osteoporosis, and rarely secondary to osteomalacia: The aim of this work was to define the influence of vitamin D-3 and parathyroid hormone (PTH) in the pathogenesis of hepatic osteodystrophy, as well as the predictive significance of biochemical bone markers. Methods: This prospective study included 58 male patients with alcoholic (49) and viral (9) cirrhosis. The concentrations of serum vitamin D-3, PTH, osteocalcin and beta-carboxy-terminal cross-linked telopeptide of type I collagen (beta-CTX) were determined. Bone density was measured by dual energy X-ray absorptiometry in the L1 -L4 spinal segment and the femoral neck. Results: Lower bone mineral density (BMD) was measured in 41 patients (70.7%). There was no significant correlation between PTH and vitamin D3 values and T score in the femoral neck (p=0.51; p=0.063) and lumbar spine (p=0.49; 0.064). Also, no significant correlation was found between the osteocalcin values in lumbar spine BMD (p=0.944) and femoral neck (p=0.161), or with beta-CTX values and BMD in the lumbar spine (p=0.347) and femoral neck (p=0.73). Statistically significant difference was confirmed between the stage A osteocalcin (p=0.000) and beta-CTX (p=0.008) values in relation to advanced stages B and C. Conclusions: PTH and vitamin D3 do not influence the development of hepatic osteodystrophy. In patients with cirrhosis, osteocalcin and beta-CTX are not valid indicators of decreased BMD, but their values correlate with the degree of liver insufficiency.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis
VL  - 33
IS  - 2
SP  - 149
EP  - 155
DO  - 10.2478/jomb-2013-0025
ER  - 

@article{
author = "Culafić-Vojinović, Violeta and Ćulafić, Đorđe and Ignjatović, Svetlana and Petakov, Milan and Đurović-Nikolić, Marina and Vasić, Jelena and Mirković, Duško and Mijac, Dragana and Stulić, Miloš",
year = "2014",
abstract = "Background: Metabolic bone disease in patients with chronic liver disease is called hepatic osteodystrophy and is primarily a sequel to osteopenia/osteoporosis, and rarely secondary to osteomalacia: The aim of this work was to define the influence of vitamin D-3 and parathyroid hormone (PTH) in the pathogenesis of hepatic osteodystrophy, as well as the predictive significance of biochemical bone markers. Methods: This prospective study included 58 male patients with alcoholic (49) and viral (9) cirrhosis. The concentrations of serum vitamin D-3, PTH, osteocalcin and beta-carboxy-terminal cross-linked telopeptide of type I collagen (beta-CTX) were determined. Bone density was measured by dual energy X-ray absorptiometry in the L1 -L4 spinal segment and the femoral neck. Results: Lower bone mineral density (BMD) was measured in 41 patients (70.7%). There was no significant correlation between PTH and vitamin D3 values and T score in the femoral neck (p=0.51; p=0.063) and lumbar spine (p=0.49; 0.064). Also, no significant correlation was found between the osteocalcin values in lumbar spine BMD (p=0.944) and femoral neck (p=0.161), or with beta-CTX values and BMD in the lumbar spine (p=0.347) and femoral neck (p=0.73). Statistically significant difference was confirmed between the stage A osteocalcin (p=0.000) and beta-CTX (p=0.008) values in relation to advanced stages B and C. Conclusions: PTH and vitamin D3 do not influence the development of hepatic osteodystrophy. In patients with cirrhosis, osteocalcin and beta-CTX are not valid indicators of decreased BMD, but their values correlate with the degree of liver insufficiency.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis",
volume = "33",
number = "2",
pages = "149-155",
doi = "10.2478/jomb-2013-0025"
}

Culafić-Vojinović, V., Ćulafić, Đ., Ignjatović, S., Petakov, M., Đurović-Nikolić, M., Vasić, J., Mirković, D., Mijac, D.,& Stulić, M.. (2014). The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 33(2), 149-155.
https://doi.org/10.2478/jomb-2013-0025

Culafić-Vojinović V, Ćulafić Đ, Ignjatović S, Petakov M, Đurović-Nikolić M, Vasić J, Mirković D, Mijac D, Stulić M. The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis. in Journal of Medical Biochemistry. 2014;33(2):149-155.
doi:10.2478/jomb-2013-0025 .

Culafić-Vojinović, Violeta, Ćulafić, Đorđe, Ignjatović, Svetlana, Petakov, Milan, Đurović-Nikolić, Marina, Vasić, Jelena, Mirković, Duško, Mijac, Dragana, Stulić, Miloš, "The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis" in Journal of Medical Biochemistry, 33, no. 2 (2014):149-155,
https://doi.org/10.2478/jomb-2013-0025 . .

TY  - JOUR
AU  - Ćulafić, Đorđe
AU  - Stulić, Miloš
AU  - Obrenović, Radmila
AU  - Miletić, Danijela
AU  - Mijac, Dragana
AU  - Stojković, Milica
AU  - Jovanović, Marija
AU  - Ćulafić, Milica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2213
AB  - AIM: To evaluate the clinical significance of cystatin C and renal resistive index for the determination of renal function in patients with liver cirrhosis. METHODS: We conducted a study of 63 patients with liver cirrhosis. A control group comprised of 30 age and gender-matched healthy persons. Serum cystatin C was determined in all study subjects and renal Doppler ultrasonography was made. Estimated glomerular filtration rate from serum creatinine (GFR(Cr)) and cystatin C (GFR(Cys)) was calculated. RESULTS: We confirmed significant differences in values of cystatin C between patients with different stages of liver cirrhosis according to Child-Pugh (P = 0.01), and a significant correlation with model of end stage liver disease (MELD) score (r(s) = 0.527, P  lt  0.001). More patients with decreased glomerular filtration rate were identified based on GFR(Cys) than on GFR(Cr) (P  lt  0.001). Significantly higher renal resistive index was noted in Child-Pugh C than in A (P  lt  0.001) and B stage (P = 0.001). Also, a significant correlation between renal resistive index and MELD score was observed (r(s) = 0.607, P  lt  0.001). Renal resistive index correlated significantly with cystatin C (r(s) = 0.283, P = 0.028) and showed a negative correlation with GFR(Cys) (r(s) = -0.31, P = 0.016). CONCLUSION: Cystatin C may be a more reliable marker for assessment of liver insufficiency. Additionally, cystatin C and renal resistive index represent sensitive indicators of renal dysfunction in patients with liver cirrhosis.
PB  - Baishideng Publishing Group Inc, Pleasanton
T2  - World Journal of Microbiology & Biotechnology
T1  - Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis
VL  - 20
IS  - 21
SP  - 6573
EP  - 6579
DO  - 10.3748/wjg.v20.i21.6573
ER  - 

@article{
author = "Ćulafić, Đorđe and Stulić, Miloš and Obrenović, Radmila and Miletić, Danijela and Mijac, Dragana and Stojković, Milica and Jovanović, Marija and Ćulafić, Milica",
year = "2014",
abstract = "AIM: To evaluate the clinical significance of cystatin C and renal resistive index for the determination of renal function in patients with liver cirrhosis. METHODS: We conducted a study of 63 patients with liver cirrhosis. A control group comprised of 30 age and gender-matched healthy persons. Serum cystatin C was determined in all study subjects and renal Doppler ultrasonography was made. Estimated glomerular filtration rate from serum creatinine (GFR(Cr)) and cystatin C (GFR(Cys)) was calculated. RESULTS: We confirmed significant differences in values of cystatin C between patients with different stages of liver cirrhosis according to Child-Pugh (P = 0.01), and a significant correlation with model of end stage liver disease (MELD) score (r(s) = 0.527, P  lt  0.001). More patients with decreased glomerular filtration rate were identified based on GFR(Cys) than on GFR(Cr) (P  lt  0.001). Significantly higher renal resistive index was noted in Child-Pugh C than in A (P  lt  0.001) and B stage (P = 0.001). Also, a significant correlation between renal resistive index and MELD score was observed (r(s) = 0.607, P  lt  0.001). Renal resistive index correlated significantly with cystatin C (r(s) = 0.283, P = 0.028) and showed a negative correlation with GFR(Cys) (r(s) = -0.31, P = 0.016). CONCLUSION: Cystatin C may be a more reliable marker for assessment of liver insufficiency. Additionally, cystatin C and renal resistive index represent sensitive indicators of renal dysfunction in patients with liver cirrhosis.",
publisher = "Baishideng Publishing Group Inc, Pleasanton",
journal = "World Journal of Microbiology & Biotechnology",
title = "Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis",
volume = "20",
number = "21",
pages = "6573-6579",
doi = "10.3748/wjg.v20.i21.6573"
}

Ćulafić, Đ., Stulić, M., Obrenović, R., Miletić, D., Mijac, D., Stojković, M., Jovanović, M.,& Ćulafić, M.. (2014). Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis. in World Journal of Microbiology & Biotechnology
Baishideng Publishing Group Inc, Pleasanton., 20(21), 6573-6579.
https://doi.org/10.3748/wjg.v20.i21.6573

Ćulafić Đ, Stulić M, Obrenović R, Miletić D, Mijac D, Stojković M, Jovanović M, Ćulafić M. Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis. in World Journal of Microbiology & Biotechnology. 2014;20(21):6573-6579.
doi:10.3748/wjg.v20.i21.6573 .

Ćulafić, Đorđe, Stulić, Miloš, Obrenović, Radmila, Miletić, Danijela, Mijac, Dragana, Stojković, Milica, Jovanović, Marija, Ćulafić, Milica, "Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis" in World Journal of Microbiology & Biotechnology, 20, no. 21 (2014):6573-6579,
https://doi.org/10.3748/wjg.v20.i21.6573 . .