TY  - CONF
AU  - Antonijević-Nikolić, Mirjana
AU  - Đuričić Milanković, Jelena
AU  - Popović, Kosana
AU  - Tanasković, Slađana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5413
AB  - Waste management is still a global challenge in the 21st century. Sustainable waste management aims to minimize the amount of solid waste that goes to landfill, keep materials in use as long as possible and thus ensure a reduction in the negative environmental, social and financial impacts of consumption. Household waste management is a challenging task because of the increasing amount of waste globally and the large quantity of different materials in this waste stream. Sorting the waste at the source, the place where it is generated, is a crucial task to promote recycling and circular economy. Primary separation of municipal waste in the Republic of Serbia is determined by the law on waste management and separate collection of plastic, paper, glass and metal is foreseen. However, waste sorting is still not a popular practice in households. Waste sorting at the source presents an initial step to recycling. This paper describes the primary separation of household waste in the urban area of Šabac, which is a part of project "Supply of equipment for solid waste source separation schemes in 4 regions". The project is implemented in four regions for waste management and include a total of seventeen cities and municipalities in Serbia. With the participation of citizens, the city of Šabac has started a project of primary waste sorting in households. Households were able to pick up bins for the primary sorting of household waste, as well as brochures with instructions. In the bins, citizens separate paper, plastic and metal waste from their households, which will later be used in the recycling process. By introducing the primary selection of household waste in this way, it is expected that the rate of recycling will increase to 15% in the next 2 years. In this way, goals such as: reduction of landfilled waste, preservation of the capacity of the Srem-Mačva sanitary landfill, contribution to recycling which results in saving energy, natural resources and money, preserves the environment, which is in accordance with the principles of sustainable development.
PB  - University of East Sarajevo, Faculty of technology
C3  - VIII International Congress “Engineering, Environment and Materials in Process Industry“, Book of abstracts, Jahorina, mart 20-23, 2023 Republika srpska, Bosna i Hercegovina
T1  - Improving solid waste managment as important step to sustainability: separation of waste in households
SP  - 426
EP  - 435
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5413
ER  - 

@conference{
author = "Antonijević-Nikolić, Mirjana and Đuričić Milanković, Jelena and Popović, Kosana and Tanasković, Slađana",
year = "2023",
abstract = "Waste management is still a global challenge in the 21st century. Sustainable waste management aims to minimize the amount of solid waste that goes to landfill, keep materials in use as long as possible and thus ensure a reduction in the negative environmental, social and financial impacts of consumption. Household waste management is a challenging task because of the increasing amount of waste globally and the large quantity of different materials in this waste stream. Sorting the waste at the source, the place where it is generated, is a crucial task to promote recycling and circular economy. Primary separation of municipal waste in the Republic of Serbia is determined by the law on waste management and separate collection of plastic, paper, glass and metal is foreseen. However, waste sorting is still not a popular practice in households. Waste sorting at the source presents an initial step to recycling. This paper describes the primary separation of household waste in the urban area of Šabac, which is a part of project "Supply of equipment for solid waste source separation schemes in 4 regions". The project is implemented in four regions for waste management and include a total of seventeen cities and municipalities in Serbia. With the participation of citizens, the city of Šabac has started a project of primary waste sorting in households. Households were able to pick up bins for the primary sorting of household waste, as well as brochures with instructions. In the bins, citizens separate paper, plastic and metal waste from their households, which will later be used in the recycling process. By introducing the primary selection of household waste in this way, it is expected that the rate of recycling will increase to 15% in the next 2 years. In this way, goals such as: reduction of landfilled waste, preservation of the capacity of the Srem-Mačva sanitary landfill, contribution to recycling which results in saving energy, natural resources and money, preserves the environment, which is in accordance with the principles of sustainable development.",
publisher = "University of East Sarajevo, Faculty of technology",
journal = "VIII International Congress “Engineering, Environment and Materials in Process Industry“, Book of abstracts, Jahorina, mart 20-23, 2023 Republika srpska, Bosna i Hercegovina",
title = "Improving solid waste managment as important step to sustainability: separation of waste in households",
pages = "426-435",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5413"
}

Antonijević-Nikolić, M., Đuričić Milanković, J., Popović, K.,& Tanasković, S.. (2023). Improving solid waste managment as important step to sustainability: separation of waste in households. in VIII International Congress “Engineering, Environment and Materials in Process Industry“, Book of abstracts, Jahorina, mart 20-23, 2023 Republika srpska, Bosna i Hercegovina
University of East Sarajevo, Faculty of technology., 426-435.
https://hdl.handle.net/21.15107/rcub_farfar_5413

Antonijević-Nikolić M, Đuričić Milanković J, Popović K, Tanasković S. Improving solid waste managment as important step to sustainability: separation of waste in households. in VIII International Congress “Engineering, Environment and Materials in Process Industry“, Book of abstracts, Jahorina, mart 20-23, 2023 Republika srpska, Bosna i Hercegovina. 2023;:426-435.
https://hdl.handle.net/21.15107/rcub_farfar_5413 .

Antonijević-Nikolić, Mirjana, Đuričić Milanković, Jelena, Popović, Kosana, Tanasković, Slađana, "Improving solid waste managment as important step to sustainability: separation of waste in households" in VIII International Congress “Engineering, Environment and Materials in Process Industry“, Book of abstracts, Jahorina, mart 20-23, 2023 Republika srpska, Bosna i Hercegovina (2023):426-435,
https://hdl.handle.net/21.15107/rcub_farfar_5413 .

TY  - CONF
AU  - Popović, Kosana
AU  - Antonijević-Nikolić, Mirjana
AU  - Đuričić-Milanković, Jelena
AU  - Ranković, Dragan
AU  - Milutinović, Bojana
AU  - Dražić, Branka
AU  - Tanasković, Slađana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5412
AB  - The stinging nettle (Urtica dioica L.) belongs to the Urticaceae family and represents a perennial plant. Stinging nettle is abundant species occurring in various types of forest, road verges and grassland sites. In many countries is used as both medicine and food. Stinging nettle is a weed and its seeds, leaves and even roots are used for medicinal purpose. Thanks to its high content of nutrients and bioactive compounds like poly phenols, vitamins and minerals, nettle possesses a great nutritional value and a large number of pharmacological effects, including anti-proliferative, anti-inflammatory, antioxidant, analgesic, immunostimulatory, anti-infectious, hypotensive, antiulcer activities and cardiovascular disease prevention. It is a reservoir of minerals (especially iron), vitamin C and pro-vitamin A.
Last decades the popularity of herbal medicine is rapidly increasing all over the world. However, heavy metal toxicity in plant materials has a great impact and importance on herbal plants and consequently affects the quality of herbal raw materials, herbal extracts, the safety and marketability of drugs. This paper presents determination of content seven heavy metals (Cu, Fe, Mn, Ni, Zn, Cd and Pb) in leaves samples Urtica dioica L. collected from five localities in Republic of Serbia. The sample preparation procedure involved dry digestion in triplicate and dissolution of the ash in 6M HCl and then in 0.1 M HNO3. All elements were analyzed using an inductively coupled plasma-optical emission spectrometry (ICP-OES). The contents of Ni, Cu, Zn, Mn and Fe in the leaves were found to be in the ranges of 0.54±0.00 to 1.87±0.10 ˂ 2.12±0.69-12.79±0.53 ˂ 18.18±0.46-28.48±1.37 ˂ 30.63±1.45-68.44±5.11, and 109.75±4.01-244.41±13.50 mg/kg dry weight, respectively. Value of toxic heavy metal Pb in two samples is 0.37±0.0 mg/kg dry weight, whiles content Cd has been below the detection limit. The content of heavy metals in samples were used to calculate target hazard quotients values (THQ) and hazard index (HI).
PB  - University of East Sarajevo,  Faculty of technology
C3  - VIII International Congress “Engineering, Environment and Materials in Process Industry“, Book of abstracts, Jahorina, mart 20-23, 2023 Republika srpska, Bosna i Hercegovina
T1  - Determination of heavy metal contents in stinging nettle from different localities in Serbia
SP  - 419
EP  - 425
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5412
ER  - 

@conference{
author = "Popović, Kosana and Antonijević-Nikolić, Mirjana and Đuričić-Milanković, Jelena and Ranković, Dragan and Milutinović, Bojana and Dražić, Branka and Tanasković, Slađana",
year = "2023",
abstract = "The stinging nettle (Urtica dioica L.) belongs to the Urticaceae family and represents a perennial plant. Stinging nettle is abundant species occurring in various types of forest, road verges and grassland sites. In many countries is used as both medicine and food. Stinging nettle is a weed and its seeds, leaves and even roots are used for medicinal purpose. Thanks to its high content of nutrients and bioactive compounds like poly phenols, vitamins and minerals, nettle possesses a great nutritional value and a large number of pharmacological effects, including anti-proliferative, anti-inflammatory, antioxidant, analgesic, immunostimulatory, anti-infectious, hypotensive, antiulcer activities and cardiovascular disease prevention. It is a reservoir of minerals (especially iron), vitamin C and pro-vitamin A.
Last decades the popularity of herbal medicine is rapidly increasing all over the world. However, heavy metal toxicity in plant materials has a great impact and importance on herbal plants and consequently affects the quality of herbal raw materials, herbal extracts, the safety and marketability of drugs. This paper presents determination of content seven heavy metals (Cu, Fe, Mn, Ni, Zn, Cd and Pb) in leaves samples Urtica dioica L. collected from five localities in Republic of Serbia. The sample preparation procedure involved dry digestion in triplicate and dissolution of the ash in 6M HCl and then in 0.1 M HNO3. All elements were analyzed using an inductively coupled plasma-optical emission spectrometry (ICP-OES). The contents of Ni, Cu, Zn, Mn and Fe in the leaves were found to be in the ranges of 0.54±0.00 to 1.87±0.10 ˂ 2.12±0.69-12.79±0.53 ˂ 18.18±0.46-28.48±1.37 ˂ 30.63±1.45-68.44±5.11, and 109.75±4.01-244.41±13.50 mg/kg dry weight, respectively. Value of toxic heavy metal Pb in two samples is 0.37±0.0 mg/kg dry weight, whiles content Cd has been below the detection limit. The content of heavy metals in samples were used to calculate target hazard quotients values (THQ) and hazard index (HI).",
publisher = "University of East Sarajevo,  Faculty of technology",
journal = "VIII International Congress “Engineering, Environment and Materials in Process Industry“, Book of abstracts, Jahorina, mart 20-23, 2023 Republika srpska, Bosna i Hercegovina",
title = "Determination of heavy metal contents in stinging nettle from different localities in Serbia",
pages = "419-425",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5412"
}

Popović, K., Antonijević-Nikolić, M., Đuričić-Milanković, J., Ranković, D., Milutinović, B., Dražić, B.,& Tanasković, S.. (2023). Determination of heavy metal contents in stinging nettle from different localities in Serbia. in VIII International Congress “Engineering, Environment and Materials in Process Industry“, Book of abstracts, Jahorina, mart 20-23, 2023 Republika srpska, Bosna i Hercegovina
University of East Sarajevo,  Faculty of technology., 419-425.
https://hdl.handle.net/21.15107/rcub_farfar_5412

Popović K, Antonijević-Nikolić M, Đuričić-Milanković J, Ranković D, Milutinović B, Dražić B, Tanasković S. Determination of heavy metal contents in stinging nettle from different localities in Serbia. in VIII International Congress “Engineering, Environment and Materials in Process Industry“, Book of abstracts, Jahorina, mart 20-23, 2023 Republika srpska, Bosna i Hercegovina. 2023;:419-425.
https://hdl.handle.net/21.15107/rcub_farfar_5412 .

Popović, Kosana, Antonijević-Nikolić, Mirjana, Đuričić-Milanković, Jelena, Ranković, Dragan, Milutinović, Bojana, Dražić, Branka, Tanasković, Slađana, "Determination of heavy metal contents in stinging nettle from different localities in Serbia" in VIII International Congress “Engineering, Environment and Materials in Process Industry“, Book of abstracts, Jahorina, mart 20-23, 2023 Republika srpska, Bosna i Hercegovina (2023):419-425,
https://hdl.handle.net/21.15107/rcub_farfar_5412 .

TY  - CONF
AU  - Stanić, Vojislav
AU  - Tanasković, Slađana
AU  - Jelić, Ivana
AU  - Janković, Marija
AU  - Jovanović, Dragoljub
AU  - Gerić, Tamara
AU  - Nastasijević, Branislav
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5332
AB  - Radijacionо zračenje predstavlja specifičan način onkološkog lečenja, kod kojeg se
antitumorski efekat postiže dejstvom jonizujućeg zračenja.Visokoenergetsko jonizujuće
zračenje oštećuje genetski materijal ćelija tumorskog tkiva i tako ograničava ili onemogućuje
njihovu sposobnost daljnjeg deljenja. Radioizotopi koji se koriste u lečenju u većini slučajeva
grenerišu beta zračenje koje izaziva uništenje obolelih ćelija. Interesovanje za razvoj 177Lu kao
radiofarmaceutika može se pripisati podobnosti njegovih nuklearnih svojstava za terapeutsku
upotrebu, emisija β(-) i γ zračenja i njegovo dobro kompleksiranje sa raznim ligandima. U
ovom radu je prikazana preliminarna sinteza kompleksa Lu(III) sa poliazamakrocikličnim
ligandom.
AB  - Radiation is a specific method of oncological treatment, in which the action of ionizing
radiation achieves the antitumor effect. High-energy ionizing radiation damages the genetic
material of tumor tissue cells and thus limits or disables their ability to divide further.
Radioisotopes used in treatment in most cases generate beta radiation that causes the
destruction of diseased cells. The interest in developing 177Lu as a radiopharmaceutical can be
attributed to the suitability of its nuclear properties for therapeutic use, the emission ofβ(-) and
γ radiation, and its good complexation with various ligands. This paper presents the
preliminary synthesis of Lu(III) complex with a polyazamacrocyclic ligand
PB  - Институт за нуклеарне науке „Винча“
PB  - Друштво за заштиту од зрачења Србије и Црне Горе
C3  - XXXII симпозијум ДЗЗСЦГ, 04-06. октобар 2023. године, Будва, Црна Гора, Зборник радова
T1  - Sinteza  lutecijuma(III) kompleksa sa poliazamakrocikličnim ligandom
T1  - Synthesis of lutetium(III) complex with a polyazamacrocyclic ligand
SP  - 395
EP  - 400
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5332
ER  - 

@conference{
author = "Stanić, Vojislav and Tanasković, Slađana and Jelić, Ivana and Janković, Marija and Jovanović, Dragoljub and Gerić, Tamara and Nastasijević, Branislav",
year = "2023",
abstract = "Radijacionо zračenje predstavlja specifičan način onkološkog lečenja, kod kojeg se
antitumorski efekat postiže dejstvom jonizujućeg zračenja.Visokoenergetsko jonizujuće
zračenje oštećuje genetski materijal ćelija tumorskog tkiva i tako ograničava ili onemogućuje
njihovu sposobnost daljnjeg deljenja. Radioizotopi koji se koriste u lečenju u većini slučajeva
grenerišu beta zračenje koje izaziva uništenje obolelih ćelija. Interesovanje za razvoj 177Lu kao
radiofarmaceutika može se pripisati podobnosti njegovih nuklearnih svojstava za terapeutsku
upotrebu, emisija β(-) i γ zračenja i njegovo dobro kompleksiranje sa raznim ligandima. U
ovom radu je prikazana preliminarna sinteza kompleksa Lu(III) sa poliazamakrocikličnim
ligandom., Radiation is a specific method of oncological treatment, in which the action of ionizing
radiation achieves the antitumor effect. High-energy ionizing radiation damages the genetic
material of tumor tissue cells and thus limits or disables their ability to divide further.
Radioisotopes used in treatment in most cases generate beta radiation that causes the
destruction of diseased cells. The interest in developing 177Lu as a radiopharmaceutical can be
attributed to the suitability of its nuclear properties for therapeutic use, the emission ofβ(-) and
γ radiation, and its good complexation with various ligands. This paper presents the
preliminary synthesis of Lu(III) complex with a polyazamacrocyclic ligand",
publisher = "Институт за нуклеарне науке „Винча“, Друштво за заштиту од зрачења Србије и Црне Горе",
journal = "XXXII симпозијум ДЗЗСЦГ, 04-06. октобар 2023. године, Будва, Црна Гора, Зборник радова",
title = "Sinteza  lutecijuma(III) kompleksa sa poliazamakrocikličnim ligandom, Synthesis of lutetium(III) complex with a polyazamacrocyclic ligand",
pages = "395-400",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5332"
}

Stanić, V., Tanasković, S., Jelić, I., Janković, M., Jovanović, D., Gerić, T.,& Nastasijević, B.. (2023). Sinteza  lutecijuma(III) kompleksa sa poliazamakrocikličnim ligandom. in XXXII симпозијум ДЗЗСЦГ, 04-06. октобар 2023. године, Будва, Црна Гора, Зборник радова
Институт за нуклеарне науке „Винча“., 395-400.
https://hdl.handle.net/21.15107/rcub_farfar_5332

Stanić V, Tanasković S, Jelić I, Janković M, Jovanović D, Gerić T, Nastasijević B. Sinteza  lutecijuma(III) kompleksa sa poliazamakrocikličnim ligandom. in XXXII симпозијум ДЗЗСЦГ, 04-06. октобар 2023. године, Будва, Црна Гора, Зборник радова. 2023;:395-400.
https://hdl.handle.net/21.15107/rcub_farfar_5332 .

Stanić, Vojislav, Tanasković, Slađana, Jelić, Ivana, Janković, Marija, Jovanović, Dragoljub, Gerić, Tamara, Nastasijević, Branislav, "Sinteza  lutecijuma(III) kompleksa sa poliazamakrocikličnim ligandom" in XXXII симпозијум ДЗЗСЦГ, 04-06. октобар 2023. године, Будва, Црна Гора, Зборник радова (2023):395-400,
https://hdl.handle.net/21.15107/rcub_farfar_5332 .

TY  - CONF
AU  - Dražić, Branka
AU  - Antonijević-Nikolić, Mirjana
AU  - Martinović-Cincović, Milena
AU  - Tanasković, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5334
AB  - The aim of this study was to investigate thermal behavior of the new complex with formula
[Cu(ala)cyc](ClO4)2∙2.5H2O. The complex was isolated and previously characterized by: elemental
analysis (C, H, N), molar conductivity, UV/Vis and FTIR spectroscopy and magnetic measurements
at room temperature. The sixcoordinate octahedral geometry around Cu(II) complexes was
proposed. The experimental data suggested that the tetradentate ligand cyclam was coordinated to
metals through four N donors and the amino carboxylate ligand coordinated via carboxylate ion.
Investigate of thermal stability can be crucial in confirming the structure as well as in assessing the
applicability of new compounds. The thermal properties of these complex have been investigated
by thermogravimetric (TG) and differential thermal analysis (DTA). Therefore, TG-DTA analysis
indicates that investigated complex decomposes exothermally in a single step in the range of 310 -
PB  - University in Banjaluka, Faculty of Technology
C3  - XIV Conference of
Chemists, Technologists and Environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka, Book of abstracts
T1  - Thermal stability of new copper(II) cyclam complex with aminocarboxylate co-ligand
SP  - 25
EP  - 25
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5334
ER  - 

@conference{
author = "Dražić, Branka and Antonijević-Nikolić, Mirjana and Martinović-Cincović, Milena and Tanasković, Slađana",
year = "2022",
abstract = "The aim of this study was to investigate thermal behavior of the new complex with formula
[Cu(ala)cyc](ClO4)2∙2.5H2O. The complex was isolated and previously characterized by: elemental
analysis (C, H, N), molar conductivity, UV/Vis and FTIR spectroscopy and magnetic measurements
at room temperature. The sixcoordinate octahedral geometry around Cu(II) complexes was
proposed. The experimental data suggested that the tetradentate ligand cyclam was coordinated to
metals through four N donors and the amino carboxylate ligand coordinated via carboxylate ion.
Investigate of thermal stability can be crucial in confirming the structure as well as in assessing the
applicability of new compounds. The thermal properties of these complex have been investigated
by thermogravimetric (TG) and differential thermal analysis (DTA). Therefore, TG-DTA analysis
indicates that investigated complex decomposes exothermally in a single step in the range of 310 -",
publisher = "University in Banjaluka, Faculty of Technology",
journal = "XIV Conference of
Chemists, Technologists and Environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka, Book of abstracts",
title = "Thermal stability of new copper(II) cyclam complex with aminocarboxylate co-ligand",
pages = "25-25",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5334"
}

Dražić, B., Antonijević-Nikolić, M., Martinović-Cincović, M.,& Tanasković, S.. (2022). Thermal stability of new copper(II) cyclam complex with aminocarboxylate co-ligand. in XIV Conference of
Chemists, Technologists and Environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka, Book of abstracts
University in Banjaluka, Faculty of Technology., 25-25.
https://hdl.handle.net/21.15107/rcub_farfar_5334

Dražić B, Antonijević-Nikolić M, Martinović-Cincović M, Tanasković S. Thermal stability of new copper(II) cyclam complex with aminocarboxylate co-ligand. in XIV Conference of
Chemists, Technologists and Environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka, Book of abstracts. 2022;:25-25.
https://hdl.handle.net/21.15107/rcub_farfar_5334 .

Dražić, Branka, Antonijević-Nikolić, Mirjana, Martinović-Cincović, Milena, Tanasković, Slađana, "Thermal stability of new copper(II) cyclam complex with aminocarboxylate co-ligand" in XIV Conference of
Chemists, Technologists and Environmentalists of Republic of Srpska, October 21-22, 2022, Banja Luka, Book of abstracts (2022):25-25,
https://hdl.handle.net/21.15107/rcub_farfar_5334 .

TY  - CONF
AU  - Antonijević Nikolić, Mirjana
AU  - Dražić, Branka
AU  - Tanasković, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4374
AB  - Two new bridged dinuclear Cu(II) compounds of tpmc (N,N',N'',N'''-tetrakis(2-pyridylmethyl)-
1,4,8,11-tetraazacyclotetradecane) and co-ligands L-leucine or L-isoleucine have been synthesized
and characterized. The complexes were prepared in the reaction [Cutpmc](ClO4)4∙6H2O and
aminocarboxylates. The complexes were characterized by elemental analysis (C, H, and N), molar
electrical conductivity and spectral methods (UV/vis and FTIR). The analytical data of the complexes
show the formation of binuclear complexes with the proposed formula [Cu2(L)tpmc](ClO4)4, L=L-
leucine (1) and L=L-isoleucine (2). The spectroscopic data suggested that the tpmc is coordinated to
Cu(II) through eight N donors and amino carboxylate ligands via their carboxylate ion moieties.
PB  - Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
T1  - New macrocyclic Cu(II) complexes with leucine/isoleucine co-ligands
VL  - II
SP  - 519
EP  - 522
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4374
ER  - 

@conference{
author = "Antonijević Nikolić, Mirjana and Dražić, Branka and Tanasković, Slađana",
year = "2022",
abstract = "Two new bridged dinuclear Cu(II) compounds of tpmc (N,N',N'',N'''-tetrakis(2-pyridylmethyl)-
1,4,8,11-tetraazacyclotetradecane) and co-ligands L-leucine or L-isoleucine have been synthesized
and characterized. The complexes were prepared in the reaction [Cutpmc](ClO4)4∙6H2O and
aminocarboxylates. The complexes were characterized by elemental analysis (C, H, and N), molar
electrical conductivity and spectral methods (UV/vis and FTIR). The analytical data of the complexes
show the formation of binuclear complexes with the proposed formula [Cu2(L)tpmc](ClO4)4, L=L-
leucine (1) and L=L-isoleucine (2). The spectroscopic data suggested that the tpmc is coordinated to
Cu(II) through eight N donors and amino carboxylate ligands via their carboxylate ion moieties.",
publisher = "Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)",
title = "New macrocyclic Cu(II) complexes with leucine/isoleucine co-ligands",
volume = "II",
pages = "519-522",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4374"
}

Antonijević Nikolić, M., Dražić, B.,& Tanasković, S.. (2022). New macrocyclic Cu(II) complexes with leucine/isoleucine co-ligands. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
Society of Physical Chemists of Serbia., II, 519-522.
https://hdl.handle.net/21.15107/rcub_farfar_4374

Antonijević Nikolić M, Dražić B, Tanasković S. New macrocyclic Cu(II) complexes with leucine/isoleucine co-ligands. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings). 2022;II:519-522.
https://hdl.handle.net/21.15107/rcub_farfar_4374 .

Antonijević Nikolić, Mirjana, Dražić, Branka, Tanasković, Slađana, "New macrocyclic Cu(II) complexes with leucine/isoleucine co-ligands" in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings), II (2022):519-522,
https://hdl.handle.net/21.15107/rcub_farfar_4374 .

TY  - CONF
AU  - Popović, Kosana
AU  - Antonijević Nikolić, Mirjana
AU  - Dražić, Branka
AU  - Tanasković, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4373
AB  - The chemical components in tea have received great interest because they are related to health. In this
study the content of five heavy metals including Cu, Fe, Mn, Zn and Ni were determined by atomic
absorption spectrometry on samples of herbal teas: Quercus cortex, Gentianae radix, Althaeae radix,
Uvae ursi folium and Glycyrrhizae radix collected from Šabac's market, Serbia. Based on the obtained
content of the metals in the analyzed herbal teas, estimated daily intake (EDI) was determined. Both
target hazard quotient (THQ) and hazard index (HI) were employed to assess the potential health risk
of studied metals in teas. The herbal tea samples analysed contain essential heavy metals (Cu, Fe,
Mn, Zn) and probably essential in trace (Ni) and could contribute to the daily dietary requirements.
The THQ from 7.76·10−4 to 5.75·10-1 and HI from 0.1059 to 0.6151 values for tea samples were lower
than 1, suggesting that consumption of tea would not cause significant health risks for consumers.
PB  - Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
T1  - The potential health risk of heavy metals in herbal tea commercially available in Šabac, Serbia
VL  - II
SP  - 489
EP  - 492
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4373
ER  - 

@conference{
author = "Popović, Kosana and Antonijević Nikolić, Mirjana and Dražić, Branka and Tanasković, Slađana",
year = "2022",
abstract = "The chemical components in tea have received great interest because they are related to health. In this
study the content of five heavy metals including Cu, Fe, Mn, Zn and Ni were determined by atomic
absorption spectrometry on samples of herbal teas: Quercus cortex, Gentianae radix, Althaeae radix,
Uvae ursi folium and Glycyrrhizae radix collected from Šabac's market, Serbia. Based on the obtained
content of the metals in the analyzed herbal teas, estimated daily intake (EDI) was determined. Both
target hazard quotient (THQ) and hazard index (HI) were employed to assess the potential health risk
of studied metals in teas. The herbal tea samples analysed contain essential heavy metals (Cu, Fe,
Mn, Zn) and probably essential in trace (Ni) and could contribute to the daily dietary requirements.
The THQ from 7.76·10−4 to 5.75·10-1 and HI from 0.1059 to 0.6151 values for tea samples were lower
than 1, suggesting that consumption of tea would not cause significant health risks for consumers.",
publisher = "Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)",
title = "The potential health risk of heavy metals in herbal tea commercially available in Šabac, Serbia",
volume = "II",
pages = "489-492",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4373"
}

Popović, K., Antonijević Nikolić, M., Dražić, B.,& Tanasković, S.. (2022). The potential health risk of heavy metals in herbal tea commercially available in Šabac, Serbia. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
Society of Physical Chemists of Serbia., II, 489-492.
https://hdl.handle.net/21.15107/rcub_farfar_4373

Popović K, Antonijević Nikolić M, Dražić B, Tanasković S. The potential health risk of heavy metals in herbal tea commercially available in Šabac, Serbia. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings). 2022;II:489-492.
https://hdl.handle.net/21.15107/rcub_farfar_4373 .

Popović, Kosana, Antonijević Nikolić, Mirjana, Dražić, Branka, Tanasković, Slađana, "The potential health risk of heavy metals in herbal tea commercially available in Šabac, Serbia" in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings), II (2022):489-492,
https://hdl.handle.net/21.15107/rcub_farfar_4373 .

TY  - JOUR
AU  - Popović, Kosana
AU  - Antonijević-Nikolić, Mirjana
AU  - Dražić, Branka
AU  - Jovanović, Dragoljub
AU  - Tanasković, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4295
AB  - Chemical components of teas have received great interest because they are related to health. In this work, data on the determination of foreign matter, loss on drying/water content, total ash and ash insoluble in hydrochloric acid are presented. The content of seven heavy metals including Cu, Fe, Mn, Zn, Ni, Cd and Pb were determined by atomic absorption spectrometry in samples of several herbal teas: Matricariae flos, Thymi herba, Menthae piperitae folium, Betulae folium, Quercus cortex, Gentianae radix, Frangulae cortex, Althaeae radix, Uvae ursi folium and Glycyrrhizae radix collected from Šabac’s market, Serbia. The sample preparation procedure involved dry digestion and dissolution of the ash in 6M HCl and then in 0.1 M HNO3. Herbal teas showed the concentration of heavy metals Cu, Fe, Mn, Zn and Ni in the range: 2.9 ± 0.1 – 22.2 ± 0.9 mg/kg, 118.5 ± 1.1 – 755.5 ± 2.5 mg/kg, 19.0 ± 5.8 – 561.0 ± 1.9 mg/kg, 6.5 ± 0.4 – 242.5 ± 1.4 mg/kg and 2.5 ± 0.1 – 10 ± 1.1 mg/kg, respectively. The level of copper in all samples was uniform. The highest content of Fe was in Thymi herba, while Mn and Zn were at maximum in Betulae folium. The levels of toxic heavy metals Cd and Pb were below the detection limit. The obtained values were compared with data available from literature. The herbal tea samples analyzed contained essential heavy metals (Cu, Fe, Mn, Zn) and probably essential in trace (Ni), and could obey the daily dietary requirements. Noncancer health risk assessment detected that the herbal teas of Betulae folium and Frangulae cortex can manifest some health risk to consumers.
PB  - Springer
T2  - Pharmaceutical Chemistry Journal
T1  - Assessment of the Quality of Herbal Teas from Šabac, Serbia in Terms of the Content of Heavy Metals
VL  - 56
IS  - 6
SP  - 827
EP  - 837
DO  - 10.1007/s11094-022-02716-w
ER  - 

@article{
author = "Popović, Kosana and Antonijević-Nikolić, Mirjana and Dražić, Branka and Jovanović, Dragoljub and Tanasković, Slađana",
year = "2022",
abstract = "Chemical components of teas have received great interest because they are related to health. In this work, data on the determination of foreign matter, loss on drying/water content, total ash and ash insoluble in hydrochloric acid are presented. The content of seven heavy metals including Cu, Fe, Mn, Zn, Ni, Cd and Pb were determined by atomic absorption spectrometry in samples of several herbal teas: Matricariae flos, Thymi herba, Menthae piperitae folium, Betulae folium, Quercus cortex, Gentianae radix, Frangulae cortex, Althaeae radix, Uvae ursi folium and Glycyrrhizae radix collected from Šabac’s market, Serbia. The sample preparation procedure involved dry digestion and dissolution of the ash in 6M HCl and then in 0.1 M HNO3. Herbal teas showed the concentration of heavy metals Cu, Fe, Mn, Zn and Ni in the range: 2.9 ± 0.1 – 22.2 ± 0.9 mg/kg, 118.5 ± 1.1 – 755.5 ± 2.5 mg/kg, 19.0 ± 5.8 – 561.0 ± 1.9 mg/kg, 6.5 ± 0.4 – 242.5 ± 1.4 mg/kg and 2.5 ± 0.1 – 10 ± 1.1 mg/kg, respectively. The level of copper in all samples was uniform. The highest content of Fe was in Thymi herba, while Mn and Zn were at maximum in Betulae folium. The levels of toxic heavy metals Cd and Pb were below the detection limit. The obtained values were compared with data available from literature. The herbal tea samples analyzed contained essential heavy metals (Cu, Fe, Mn, Zn) and probably essential in trace (Ni), and could obey the daily dietary requirements. Noncancer health risk assessment detected that the herbal teas of Betulae folium and Frangulae cortex can manifest some health risk to consumers.",
publisher = "Springer",
journal = "Pharmaceutical Chemistry Journal",
title = "Assessment of the Quality of Herbal Teas from Šabac, Serbia in Terms of the Content of Heavy Metals",
volume = "56",
number = "6",
pages = "827-837",
doi = "10.1007/s11094-022-02716-w"
}

Popović, K., Antonijević-Nikolić, M., Dražić, B., Jovanović, D.,& Tanasković, S.. (2022). Assessment of the Quality of Herbal Teas from Šabac, Serbia in Terms of the Content of Heavy Metals. in Pharmaceutical Chemistry Journal
Springer., 56(6), 827-837.
https://doi.org/10.1007/s11094-022-02716-w

Popović K, Antonijević-Nikolić M, Dražić B, Jovanović D, Tanasković S. Assessment of the Quality of Herbal Teas from Šabac, Serbia in Terms of the Content of Heavy Metals. in Pharmaceutical Chemistry Journal. 2022;56(6):827-837.
doi:10.1007/s11094-022-02716-w .

Popović, Kosana, Antonijević-Nikolić, Mirjana, Dražić, Branka, Jovanović, Dragoljub, Tanasković, Slađana, "Assessment of the Quality of Herbal Teas from Šabac, Serbia in Terms of the Content of Heavy Metals" in Pharmaceutical Chemistry Journal, 56, no. 6 (2022):827-837,
https://doi.org/10.1007/s11094-022-02716-w . .

TY  - JOUR
AU  - Dražić, Branka
AU  - Antonijević-Nikolić, Mirjana
AU  - Marinović-Cincović, Milena
AU  - Živković-Radovanović, Vukosava
AU  - Borović, Branka
AU  - Tanasković, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4205
AB  - Two new cationic Cu(II) complexes of cyclam (1,4,8,11-tetraaza- cyclotetradecane) and aminocarboxylate coligands glycine or alanine have been synthesized. The complexes were characterized by elemental analysis (C, H and N), molar electrical conductivity, magnetic susceptibility measurement at room temperature, spectral methods (UV/Vis and Fourier transform infrared), as well as by thermogravimetric (TG) and differential thermal analysis (DTA). The analytical data of the complexes show the formation of mononuclear com- plexes with general formula [Cu(L)cyc](ClO4 )2⋅nH2 O, A) L = glycine, n = 1.5 and B) L = alanine, n = 2.5. The tetradentate ligand cyclam was coordinated to metals through four N donors. The spectroscopic data suggested that the amino carboxylate ligands coordinated via their carboxylate ion moieties. The six- -coordinate octahedral geometry around Cu(II) in both complexes was pre- sumed. TG-DTA analysis indicated that complex B decomposed exothermally in a single step in the range of 310–400 °C. The cytotoxic activity of Cu(II) complexes and the starting ligands were tested against human cervix adenocar- cinoma cell line (HeLa), human melanoma (FemX) and human colon carci- noma (LS174). The IC50 values for the Cu(II) complexes were from 48.35– –82.25 μM. Both complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans.
AB  - Синтетисана су два нова катјонска Cu(II) комплекса са цикламом (1,4,8,11-тетра- азациклотетрадекан) и аминокарбоксилатним колигандима: глицином или аланином. Комплекси су окарактерисани елементалном анализом (C, H, N), моларном електрич- ном проводљивошћу, мерењем магнетног момента на собној температури, спектралним методама (UV/Vis и Fourier трансфомисаном инфрацрвеном спектроскопијом) као и термогравиметријском (TG) и диференцијалном термијском (DTA) анализом. Анали- тички подаци комплекса показују формирање мононуклеарних комплекса опште фор- муле [Cu(L)cyc](ClO4) 2∙nH2O, A) L = глицин, n = 1,5 и B) L = аланин, n = 2,5. Тетра- дентатни лиганд циклам је координован са металима преко четири N донора. Спектро- скопски подаци сугеришу да су аминокарбоксилатни лиганди координовани преко својих карбоксилатних јона. У оба комплекса претпостављена је октаедарска геометрија око Cu(II). TG-DTA анализа показује да се комплекс B егзотермно разлаже у једном кораку у опсегу од 310–400 °C. Цитотоксична активност Cu(II) комплекса и почетних лиганада је тестирана na ћелијским линијама хуманог аденокарцинома грлића мате- рице (HeLa), хуманог меланома (FemiX) и хуманог карцинома дебелог црева (LS174). Вредности IC50 за комплексe Cu(II) биле су од 48,35 до 82,25 μМ. Антимикробна активност oба комплекса je тестирана према Staphylococcus aureus, Bacillus subtilis, Esche- richia coli и Candida albicans.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies
T1  - Нови комплекси бакaр(ii)-циклама са аминокарбоксилатним
колигандима: синтеза, карактеризација и in vitro
антипролиферативна и антибактеријска анализа
VL  - 87
IS  - 4
SP  - 451
EP  - 464
DO  - 10.2298/JSC211107026D
ER  - 

@article{
author = "Dražić, Branka and Antonijević-Nikolić, Mirjana and Marinović-Cincović, Milena and Živković-Radovanović, Vukosava and Borović, Branka and Tanasković, Slađana",
year = "2022",
abstract = "Two new cationic Cu(II) complexes of cyclam (1,4,8,11-tetraaza- cyclotetradecane) and aminocarboxylate coligands glycine or alanine have been synthesized. The complexes were characterized by elemental analysis (C, H and N), molar electrical conductivity, magnetic susceptibility measurement at room temperature, spectral methods (UV/Vis and Fourier transform infrared), as well as by thermogravimetric (TG) and differential thermal analysis (DTA). The analytical data of the complexes show the formation of mononuclear com- plexes with general formula [Cu(L)cyc](ClO4 )2⋅nH2 O, A) L = glycine, n = 1.5 and B) L = alanine, n = 2.5. The tetradentate ligand cyclam was coordinated to metals through four N donors. The spectroscopic data suggested that the amino carboxylate ligands coordinated via their carboxylate ion moieties. The six- -coordinate octahedral geometry around Cu(II) in both complexes was pre- sumed. TG-DTA analysis indicated that complex B decomposed exothermally in a single step in the range of 310–400 °C. The cytotoxic activity of Cu(II) complexes and the starting ligands were tested against human cervix adenocar- cinoma cell line (HeLa), human melanoma (FemX) and human colon carci- noma (LS174). The IC50 values for the Cu(II) complexes were from 48.35– –82.25 μM. Both complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans., Синтетисана су два нова катјонска Cu(II) комплекса са цикламом (1,4,8,11-тетра- азациклотетрадекан) и аминокарбоксилатним колигандима: глицином или аланином. Комплекси су окарактерисани елементалном анализом (C, H, N), моларном електрич- ном проводљивошћу, мерењем магнетног момента на собној температури, спектралним методама (UV/Vis и Fourier трансфомисаном инфрацрвеном спектроскопијом) као и термогравиметријском (TG) и диференцијалном термијском (DTA) анализом. Анали- тички подаци комплекса показују формирање мононуклеарних комплекса опште фор- муле [Cu(L)cyc](ClO4) 2∙nH2O, A) L = глицин, n = 1,5 и B) L = аланин, n = 2,5. Тетра- дентатни лиганд циклам је координован са металима преко четири N донора. Спектро- скопски подаци сугеришу да су аминокарбоксилатни лиганди координовани преко својих карбоксилатних јона. У оба комплекса претпостављена је октаедарска геометрија око Cu(II). TG-DTA анализа показује да се комплекс B егзотермно разлаже у једном кораку у опсегу од 310–400 °C. Цитотоксична активност Cu(II) комплекса и почетних лиганада је тестирана na ћелијским линијама хуманог аденокарцинома грлића мате- рице (HeLa), хуманог меланома (FemiX) и хуманог карцинома дебелог црева (LS174). Вредности IC50 за комплексe Cu(II) биле су од 48,35 до 82,25 μМ. Антимикробна активност oба комплекса je тестирана према Staphylococcus aureus, Bacillus subtilis, Esche- richia coli и Candida albicans.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies, Нови комплекси бакaр(ii)-циклама са аминокарбоксилатним
колигандима: синтеза, карактеризација и in vitro
антипролиферативна и антибактеријска анализа",
volume = "87",
number = "4",
pages = "451-464",
doi = "10.2298/JSC211107026D"
}

Dražić, B., Antonijević-Nikolić, M., Marinović-Cincović, M., Živković-Radovanović, V., Borović, B.,& Tanasković, S.. (2022). New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 87(4), 451-464.
https://doi.org/10.2298/JSC211107026D

Dražić B, Antonijević-Nikolić M, Marinović-Cincović M, Živković-Radovanović V, Borović B, Tanasković S. New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies. in Journal of the Serbian Chemical Society. 2022;87(4):451-464.
doi:10.2298/JSC211107026D .

Dražić, Branka, Antonijević-Nikolić, Mirjana, Marinović-Cincović, Milena, Živković-Radovanović, Vukosava, Borović, Branka, Tanasković, Slađana, "New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies" in Journal of the Serbian Chemical Society, 87, no. 4 (2022):451-464,
https://doi.org/10.2298/JSC211107026D . .

TY  - JOUR
AU  - Antonijević Nikolić, Mirjana
AU  - Dražić, Branka
AU  - Beata, Cristóvão
AU  - Bartyzel, Agata
AU  - Miroslaw, Barbara
AU  - Tanasković, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4193
AB  - New cationic complexes of Cu(II) with bridged aminocarboxylates: glycine and alanine, as well as octaazamacrocyclic ligand N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), with general formula [Cu2(L)tpmc](ClO4)4∙Y, (1): L=glycine, Y=2H2O and (2): L=alanine, Y=CH3CN were synthesized. Characterization of the complexes was performed by elemental analysis (C, H, N, Cu), UV/Vis, FTIR spectroscopy and magnetic measurements. The single crystal X-ray analyses results show that reported compounds were obtained as hydrates with formulae [Cu2(gly)tpmc](ClO4)4⋅6.5H2O (M1) and [Cu2(ala)tpmc](ClO4)4⋅5H2O (M2). They crystallize in the orthorhombic system, P212121 space group. The metal centers are bridged by the carboxylate group of the glycine/alanine and bound via nitrogen atoms of tmpc. In the complex M1/M2, geometry around Cu(II) coordination sphere is square pyramidal (M1: τ5 = 0.10/0.33; M2: τ5 = 0.04/0.30). In the crystal structure of M1 and M2 the amino acids exist as a zwitterion. The temperature dependence of magnetic susceptibility indicated very weak ferromagnetic interaction between two Cu(II) ions. The antiproliferative effect of the complexes, the free ligands, and cis-platin, as referent cytostatic drug, were tested against human leukemia monocytic cell line (THP-1), leukemic T cell lymphoblast (JURKAT) and Human Caucasian Burkitt′s lymphoma (RAMOS). The IC50 values for the complexes were from 37.9 ± 2.6 to 63.05 ± 0.72 µM.
PB  - Elsevier B.V.
T2  - Journal of Molecular Structure
T1  - New azamacrocyclic binuclear Cu(II) aminocarboxylate complexes: Structural, magnetic, spectral and antiproliferative studies
VL  - 1252
DO  - 10.1016/j.molstruc.2021.131969
ER  - 

@article{
author = "Antonijević Nikolić, Mirjana and Dražić, Branka and Beata, Cristóvão and Bartyzel, Agata and Miroslaw, Barbara and Tanasković, Slađana",
year = "2022",
abstract = "New cationic complexes of Cu(II) with bridged aminocarboxylates: glycine and alanine, as well as octaazamacrocyclic ligand N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), with general formula [Cu2(L)tpmc](ClO4)4∙Y, (1): L=glycine, Y=2H2O and (2): L=alanine, Y=CH3CN were synthesized. Characterization of the complexes was performed by elemental analysis (C, H, N, Cu), UV/Vis, FTIR spectroscopy and magnetic measurements. The single crystal X-ray analyses results show that reported compounds were obtained as hydrates with formulae [Cu2(gly)tpmc](ClO4)4⋅6.5H2O (M1) and [Cu2(ala)tpmc](ClO4)4⋅5H2O (M2). They crystallize in the orthorhombic system, P212121 space group. The metal centers are bridged by the carboxylate group of the glycine/alanine and bound via nitrogen atoms of tmpc. In the complex M1/M2, geometry around Cu(II) coordination sphere is square pyramidal (M1: τ5 = 0.10/0.33; M2: τ5 = 0.04/0.30). In the crystal structure of M1 and M2 the amino acids exist as a zwitterion. The temperature dependence of magnetic susceptibility indicated very weak ferromagnetic interaction between two Cu(II) ions. The antiproliferative effect of the complexes, the free ligands, and cis-platin, as referent cytostatic drug, were tested against human leukemia monocytic cell line (THP-1), leukemic T cell lymphoblast (JURKAT) and Human Caucasian Burkitt′s lymphoma (RAMOS). The IC50 values for the complexes were from 37.9 ± 2.6 to 63.05 ± 0.72 µM.",
publisher = "Elsevier B.V.",
journal = "Journal of Molecular Structure",
title = "New azamacrocyclic binuclear Cu(II) aminocarboxylate complexes: Structural, magnetic, spectral and antiproliferative studies",
volume = "1252",
doi = "10.1016/j.molstruc.2021.131969"
}

Antonijević Nikolić, M., Dražić, B., Beata, C., Bartyzel, A., Miroslaw, B.,& Tanasković, S.. (2022). New azamacrocyclic binuclear Cu(II) aminocarboxylate complexes: Structural, magnetic, spectral and antiproliferative studies. in Journal of Molecular Structure
Elsevier B.V.., 1252.
https://doi.org/10.1016/j.molstruc.2021.131969

Antonijević Nikolić M, Dražić B, Beata C, Bartyzel A, Miroslaw B, Tanasković S. New azamacrocyclic binuclear Cu(II) aminocarboxylate complexes: Structural, magnetic, spectral and antiproliferative studies. in Journal of Molecular Structure. 2022;1252.
doi:10.1016/j.molstruc.2021.131969 .

Antonijević Nikolić, Mirjana, Dražić, Branka, Beata, Cristóvão, Bartyzel, Agata, Miroslaw, Barbara, Tanasković, Slađana, "New azamacrocyclic binuclear Cu(II) aminocarboxylate complexes: Structural, magnetic, spectral and antiproliferative studies" in Journal of Molecular Structure, 1252 (2022),
https://doi.org/10.1016/j.molstruc.2021.131969 . .

TY  - JOUR
AU  - Pavun, Leposava
AU  - Janošević-Ležaić, Aleksandra
AU  - Tanasković, Slađana
AU  - Ušjak, Dušan
AU  - Milenković, Marina
AU  - Uskoković-Marković, Snežana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4055
AB  - The presence of residual cardiovascular disease (CVD) risk is a current dilemma in clinical practice; indeed, despite optimal management and treatment, a considerable proportion of patients still undergo major CV events. Novel lipoprotein biomarkers are suggested as possible targets for improving the outcomes of patients at higher risk for CVD, and their impact on major CV events and mortality have previously been investigated. Innovative antidiabetic therapies have recently shown a significant reduction in atherogenic lipoproteins, beyond their effects on glucose parameters; it has also been suggested that such anti-atherogenic effect may represent a valuable mechanistic explanation for the cardiovascular benefit of, at least, some of the novel antidiabetic agents, such as glucagon-like peptide-1 receptor agonists. This emphasizes the need for further research in the field in order to clearly assess the effects of innovative treatments on different novel biomarkers, including atherogenic lipoproteins, such as small dense low-density lipoprotein (LDL), lipoprotein(a) (Lp(a)) and dysfunctional high-density lipoprotein (HDL). The current article discusses the clinical importance of novel lipid biomarkers for better management of patients in order to overcome residual cardiovascular risk.
AB  - Постои постојана потреба од ефикасни лекови, комбинации на лекови и методи за спречување на бактериски и вирусни инфекции, вклучувајќи го и коронавирусот. Познато е дека улогата на елементи во траги во зајакнување на човековиот имун систем е значајна. Витамините, микроелементите, вклучувајќи цинк, железо, селен, магнезиум и бакар, масните киселини омега-3 играат значајна физиолошка улога во унапредување на имуниот систем. Цинкот е неопходен микроелемент за основните ензимски физиолошки процеси. Тој игра важна улога во делбата на клетките и е вклучен во развојот на клетки одговорни за неспецифичен имунитет. Познато е дека недостигот на цинк ги предиспонира пациентите на вирусни инфекции поради намалениот антивирусен имунитет. Од друга страна, флавоноидите како метаболити на растенијата играат важна улога во спречување на оксидативен стрес. Овој труд има за цел да ја дискутира in vitro улогата на цинкот, флавонидите и нивните комплекси, како и нивните антиоксидативни и антимикорбни активности. Разгледана е и оправданоста за истовремена употреба на цинк и флавоноиди.
PB  - Macedonian Journal of Chemistry and Chemical Engineering
T2  - Macedonian Journal of Chemistry and Chemical Engineering
T1  - Antioxidant capacity and antimicrobial effects of zinc complexes of flavonoids – does synergism exist?
T1  - Aнтиоксидативен капацитет и антимикробни ефекти на комплекси
на цинк со флавоноиди – дали постои синергизам?
VL  - 40
IS  - 2
SP  - 231
EP  - 239
DO  - 10.20450/mjcce.2021.2401
ER  - 

@article{
author = "Pavun, Leposava and Janošević-Ležaić, Aleksandra and Tanasković, Slađana and Ušjak, Dušan and Milenković, Marina and Uskoković-Marković, Snežana",
year = "2021",
abstract = "The presence of residual cardiovascular disease (CVD) risk is a current dilemma in clinical practice; indeed, despite optimal management and treatment, a considerable proportion of patients still undergo major CV events. Novel lipoprotein biomarkers are suggested as possible targets for improving the outcomes of patients at higher risk for CVD, and their impact on major CV events and mortality have previously been investigated. Innovative antidiabetic therapies have recently shown a significant reduction in atherogenic lipoproteins, beyond their effects on glucose parameters; it has also been suggested that such anti-atherogenic effect may represent a valuable mechanistic explanation for the cardiovascular benefit of, at least, some of the novel antidiabetic agents, such as glucagon-like peptide-1 receptor agonists. This emphasizes the need for further research in the field in order to clearly assess the effects of innovative treatments on different novel biomarkers, including atherogenic lipoproteins, such as small dense low-density lipoprotein (LDL), lipoprotein(a) (Lp(a)) and dysfunctional high-density lipoprotein (HDL). The current article discusses the clinical importance of novel lipid biomarkers for better management of patients in order to overcome residual cardiovascular risk., Постои постојана потреба од ефикасни лекови, комбинации на лекови и методи за спречување на бактериски и вирусни инфекции, вклучувајќи го и коронавирусот. Познато е дека улогата на елементи во траги во зајакнување на човековиот имун систем е значајна. Витамините, микроелементите, вклучувајќи цинк, железо, селен, магнезиум и бакар, масните киселини омега-3 играат значајна физиолошка улога во унапредување на имуниот систем. Цинкот е неопходен микроелемент за основните ензимски физиолошки процеси. Тој игра важна улога во делбата на клетките и е вклучен во развојот на клетки одговорни за неспецифичен имунитет. Познато е дека недостигот на цинк ги предиспонира пациентите на вирусни инфекции поради намалениот антивирусен имунитет. Од друга страна, флавоноидите како метаболити на растенијата играат важна улога во спречување на оксидативен стрес. Овој труд има за цел да ја дискутира in vitro улогата на цинкот, флавонидите и нивните комплекси, како и нивните антиоксидативни и антимикорбни активности. Разгледана е и оправданоста за истовремена употреба на цинк и флавоноиди.",
publisher = "Macedonian Journal of Chemistry and Chemical Engineering",
journal = "Macedonian Journal of Chemistry and Chemical Engineering",
title = "Antioxidant capacity and antimicrobial effects of zinc complexes of flavonoids – does synergism exist?, Aнтиоксидативен капацитет и антимикробни ефекти на комплекси
на цинк со флавоноиди – дали постои синергизам?",
volume = "40",
number = "2",
pages = "231-239",
doi = "10.20450/mjcce.2021.2401"
}

Pavun, L., Janošević-Ležaić, A., Tanasković, S., Ušjak, D., Milenković, M.,& Uskoković-Marković, S.. (2021). Antioxidant capacity and antimicrobial effects of zinc complexes of flavonoids – does synergism exist?. in Macedonian Journal of Chemistry and Chemical Engineering
Macedonian Journal of Chemistry and Chemical Engineering., 40(2), 231-239.
https://doi.org/10.20450/mjcce.2021.2401

Pavun L, Janošević-Ležaić A, Tanasković S, Ušjak D, Milenković M, Uskoković-Marković S. Antioxidant capacity and antimicrobial effects of zinc complexes of flavonoids – does synergism exist?. in Macedonian Journal of Chemistry and Chemical Engineering. 2021;40(2):231-239.
doi:10.20450/mjcce.2021.2401 .

Pavun, Leposava, Janošević-Ležaić, Aleksandra, Tanasković, Slađana, Ušjak, Dušan, Milenković, Marina, Uskoković-Marković, Snežana, "Antioxidant capacity and antimicrobial effects of zinc complexes of flavonoids – does synergism exist?" in Macedonian Journal of Chemistry and Chemical Engineering, 40, no. 2 (2021):231-239,
https://doi.org/10.20450/mjcce.2021.2401 . .

TY  - JOUR
AU  - Tanasković, Slađana
AU  - Antonijević-Nikolić, Mirjana
AU  - Dražić, Branka
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4051
AB  - A large number of interesting Co (II) complexes with macrocyclicligands have been synthesized and the recognition of its complexes as important bioactive compounds in vitro and in vivo has aroused growing interest in these agents as potential drugs for therapeutic use in various diseases. Numerous available information on their bioinorganic properties and mode of action in several biological systems, combined with the new possibilities imposed by the development of medical chemistry, opens space for the development of a new generation of highly active drugs with minimized side effects which could add significantly to the current clinical research and practice. In this paper we attempt to present some properties of the earlier isolated the first Co(II)tpmc complex for which crystal structure confirmed chair conformation of macrocycle. Complex with formula [Co2(Cl)2tpmc](BF4)2 (tpmc = N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane), was studied on thermal behaviour and biological activity. TG-DTA analysis indicates that complex decomposition in a single step in the range of 365-435 °C. Investigated cytotoxic activity against two human cancer cell lines: HeLa (human cervix adenocarcinoma) and K562 (human myelogenous leukaemia). Complex was also preliminary assayed in vitro toward bacteria, fungi and mould together with the starting material for the synthesis (ligands, simple salts and solvents) as test substances. Investigated complex showed a moderate activity against strains of bacteria and were inactive against the tested fungi and mould. Minimal inhibitory concentration suppressing the visible growth of bacteria was determined. Biological investigations show the complex has significant cytotoxic potential.
AB  - Poznavanje biološke uloge kobalta i prepoznavanje njegovih kompleksa kao važnih bioaktivnih jedinjenja razlozi su sve veće zainteresovanosti za potencijalnu terapijsku primenu ovih kompleksa kod različitih bolesti. Brojne dostupne informacije o njihovim osobinama i načinu delovanja u nekoliko bioloških sistema, u kombinaciji sa novim mogućnostima koje nameće razvoj medicinske hemije, otvaraju prostor za razvoj nove generacije visoko aktivnih lekova sa minimalnim nuspojavama. U ovom radu smo ispitali neke osobine ranije izolovanog Co (II) tpmc kompleksa, prvog kod koga je rendgenska strukturna analiza potvrdila da se makrciklični ligand nalazi u konformaciji stolice. Ispitivane su termogravimetrijske I biološke osobine kompleksa [Co2(Cl)2tpmc](BF4)2 (tpmc = N, N', N'', N'''-tetrakis (2-piridilmetil) -1,4,8,11-tetraazaciklotetradekan). TG-DTA analiza ukazuje da je razlaganje kompleksa u jednom koraku u rasponu temperature od 365 -435 ° C. Ispitivana je citotoksična aktivnost na dve ljudske ćelijske linije karcinoma: HeLa (adenokarcinom grlića maternice) i K562 (mijelogena leukemija). Antimikrobno djelovanje kompleksa kvantifikovano je određivanjem minimalne inhibitorne koncentracije (MIC) korišćenjem bakterija Staphylococcus saprophyticus, Staphylococcus xylosus, Bacillus cereus, soja kvasca Candida albicans i plesni Aspergillus niger. Biološka ispitivanja su pokazala da kompleks ima značajan citotoksični potencijal I umerenu aktivnost prema bakterijama soja Staphylococcus.
PB  - Engineers Society for Corrosion
T2  - Materials Protection
T1  - Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex
T1  - Termičko ponašanje i biološka aktivnost [co2(cl)2 tpmc](bf4)2 kompleksa
VL  - 62
IS  - 4
SP  - 291
EP  - 296
DO  - 10.5937/zasmat2104291T
ER  - 

@article{
author = "Tanasković, Slađana and Antonijević-Nikolić, Mirjana and Dražić, Branka",
year = "2021",
abstract = "A large number of interesting Co (II) complexes with macrocyclicligands have been synthesized and the recognition of its complexes as important bioactive compounds in vitro and in vivo has aroused growing interest in these agents as potential drugs for therapeutic use in various diseases. Numerous available information on their bioinorganic properties and mode of action in several biological systems, combined with the new possibilities imposed by the development of medical chemistry, opens space for the development of a new generation of highly active drugs with minimized side effects which could add significantly to the current clinical research and practice. In this paper we attempt to present some properties of the earlier isolated the first Co(II)tpmc complex for which crystal structure confirmed chair conformation of macrocycle. Complex with formula [Co2(Cl)2tpmc](BF4)2 (tpmc = N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane), was studied on thermal behaviour and biological activity. TG-DTA analysis indicates that complex decomposition in a single step in the range of 365-435 °C. Investigated cytotoxic activity against two human cancer cell lines: HeLa (human cervix adenocarcinoma) and K562 (human myelogenous leukaemia). Complex was also preliminary assayed in vitro toward bacteria, fungi and mould together with the starting material for the synthesis (ligands, simple salts and solvents) as test substances. Investigated complex showed a moderate activity against strains of bacteria and were inactive against the tested fungi and mould. Minimal inhibitory concentration suppressing the visible growth of bacteria was determined. Biological investigations show the complex has significant cytotoxic potential., Poznavanje biološke uloge kobalta i prepoznavanje njegovih kompleksa kao važnih bioaktivnih jedinjenja razlozi su sve veće zainteresovanosti za potencijalnu terapijsku primenu ovih kompleksa kod različitih bolesti. Brojne dostupne informacije o njihovim osobinama i načinu delovanja u nekoliko bioloških sistema, u kombinaciji sa novim mogućnostima koje nameće razvoj medicinske hemije, otvaraju prostor za razvoj nove generacije visoko aktivnih lekova sa minimalnim nuspojavama. U ovom radu smo ispitali neke osobine ranije izolovanog Co (II) tpmc kompleksa, prvog kod koga je rendgenska strukturna analiza potvrdila da se makrciklični ligand nalazi u konformaciji stolice. Ispitivane su termogravimetrijske I biološke osobine kompleksa [Co2(Cl)2tpmc](BF4)2 (tpmc = N, N', N'', N'''-tetrakis (2-piridilmetil) -1,4,8,11-tetraazaciklotetradekan). TG-DTA analiza ukazuje da je razlaganje kompleksa u jednom koraku u rasponu temperature od 365 -435 ° C. Ispitivana je citotoksična aktivnost na dve ljudske ćelijske linije karcinoma: HeLa (adenokarcinom grlića maternice) i K562 (mijelogena leukemija). Antimikrobno djelovanje kompleksa kvantifikovano je određivanjem minimalne inhibitorne koncentracije (MIC) korišćenjem bakterija Staphylococcus saprophyticus, Staphylococcus xylosus, Bacillus cereus, soja kvasca Candida albicans i plesni Aspergillus niger. Biološka ispitivanja su pokazala da kompleks ima značajan citotoksični potencijal I umerenu aktivnost prema bakterijama soja Staphylococcus.",
publisher = "Engineers Society for Corrosion",
journal = "Materials Protection",
title = "Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex, Termičko ponašanje i biološka aktivnost [co2(cl)2 tpmc](bf4)2 kompleksa",
volume = "62",
number = "4",
pages = "291-296",
doi = "10.5937/zasmat2104291T"
}

Tanasković, S., Antonijević-Nikolić, M.,& Dražić, B.. (2021). Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex. in Materials Protection
Engineers Society for Corrosion., 62(4), 291-296.
https://doi.org/10.5937/zasmat2104291T

Tanasković S, Antonijević-Nikolić M, Dražić B. Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex. in Materials Protection. 2021;62(4):291-296.
doi:10.5937/zasmat2104291T .

Tanasković, Slađana, Antonijević-Nikolić, Mirjana, Dražić, Branka, "Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex" in Materials Protection, 62, no. 4 (2021):291-296,
https://doi.org/10.5937/zasmat2104291T . .

TY  - JOUR
AU  - Antonijević Nikolić, Mirjana
AU  - Mészáros Szécsényi, Katalin
AU  - Dražić, Branka
AU  - Rodić, Marko
AU  - Stanić, Vojislav
AU  - Tanasković, Slađana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3811
AB  - In vitro cytotoxic evaluation, formation constants and thermal stability of four mixed-ligand Co(II) complexes with tpmc = N,N',N",N'"-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane and carboxylate/dicarboxylate co-ligands of formulas [Co2(benz)2tpmc](ClO4)2•3H2O (1), benz– = benzoate anion; [Co2(L)tpmc](ClO4)2•nH2O, L = pht2– (phthalate dianion), n=2 (2), L = ipht2– (isophthalate dianion), n=4 (3) and L = tpht2–(terephthalate dianion), n=4 (4) are reported. The stoichiometric composition of the compounds in the solution were determined spectrophotometrically using Job's methods. Formation constants, K and Gibbs free energy, ΔG values were calculated. The thermal behavior of the complexes was investigated by simultaneous TG/DSC and TG – MS measurements. The cytotoxic effect of the complexes, the free ligands, the DMSO solvent and cis-platin, as referent cytostatic drug, was evaluated on Human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The IC50 values were between 12.7–42.3 μM. The first crystal structure determination of the Co(II) complex [Co2(µ-pht)tpmc](ClO4)2•H2O with boat conformation of tpmc ligand, was also done. The complex crystallizes in monoclinic crystal system, C2/c space group. The geometries around both Co(II) atoms are highly distorted octahedral. The Co(II) ions exhibit CoN4O2 coordination environments with the four nitrogen donor atoms of the tpmc ligand and two oxygen atoms belonging to the one carboxylate group of pht2− ligand. The carboxylate groups of pht2− are coordinated in an endo-bidentate mode. The tpmc ligand adopted a boat conformation in which the two coordinated Co(II) atoms are located on the same side of the ring, with Co•••Co distance amounting 5.4799(5) Å.
PB  - Elsevier B.V.
T2  - Journal of Molecular Structure
T1  - Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior
VL  - 1236
DO  - 10.1016/j.molstruc.2021.130133
ER  - 

@article{
author = "Antonijević Nikolić, Mirjana and Mészáros Szécsényi, Katalin and Dražić, Branka and Rodić, Marko and Stanić, Vojislav and Tanasković, Slađana",
year = "2021",
abstract = "In vitro cytotoxic evaluation, formation constants and thermal stability of four mixed-ligand Co(II) complexes with tpmc = N,N',N",N'"-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane and carboxylate/dicarboxylate co-ligands of formulas [Co2(benz)2tpmc](ClO4)2•3H2O (1), benz– = benzoate anion; [Co2(L)tpmc](ClO4)2•nH2O, L = pht2– (phthalate dianion), n=2 (2), L = ipht2– (isophthalate dianion), n=4 (3) and L = tpht2–(terephthalate dianion), n=4 (4) are reported. The stoichiometric composition of the compounds in the solution were determined spectrophotometrically using Job's methods. Formation constants, K and Gibbs free energy, ΔG values were calculated. The thermal behavior of the complexes was investigated by simultaneous TG/DSC and TG – MS measurements. The cytotoxic effect of the complexes, the free ligands, the DMSO solvent and cis-platin, as referent cytostatic drug, was evaluated on Human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The IC50 values were between 12.7–42.3 μM. The first crystal structure determination of the Co(II) complex [Co2(µ-pht)tpmc](ClO4)2•H2O with boat conformation of tpmc ligand, was also done. The complex crystallizes in monoclinic crystal system, C2/c space group. The geometries around both Co(II) atoms are highly distorted octahedral. The Co(II) ions exhibit CoN4O2 coordination environments with the four nitrogen donor atoms of the tpmc ligand and two oxygen atoms belonging to the one carboxylate group of pht2− ligand. The carboxylate groups of pht2− are coordinated in an endo-bidentate mode. The tpmc ligand adopted a boat conformation in which the two coordinated Co(II) atoms are located on the same side of the ring, with Co•••Co distance amounting 5.4799(5) Å.",
publisher = "Elsevier B.V.",
journal = "Journal of Molecular Structure",
title = "Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior",
volume = "1236",
doi = "10.1016/j.molstruc.2021.130133"
}

Antonijević Nikolić, M., Mészáros Szécsényi, K., Dražić, B., Rodić, M., Stanić, V.,& Tanasković, S.. (2021). Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior. in Journal of Molecular Structure
Elsevier B.V.., 1236.
https://doi.org/10.1016/j.molstruc.2021.130133

Antonijević Nikolić M, Mészáros Szécsényi K, Dražić B, Rodić M, Stanić V, Tanasković S. Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior. in Journal of Molecular Structure. 2021;1236.
doi:10.1016/j.molstruc.2021.130133 .

Antonijević Nikolić, Mirjana, Mészáros Szécsényi, Katalin, Dražić, Branka, Rodić, Marko, Stanić, Vojislav, Tanasković, Slađana, "Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior" in Journal of Molecular Structure, 1236 (2021),
https://doi.org/10.1016/j.molstruc.2021.130133 . .

TY  - CHAP
AU  - Stanić, Vojislav
AU  - Tanasković, Slađana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4372
AB  - Mortality rate caused by multidrug-resistant bacterial infection is reported to be considerably high in the world. This chapter introduces metal oxide nanoparticles (MO-NPs) as antimicrobial agents. It starts by presenting the effect of physicochemical properties of MO-NPs such as: chemical composition, particle size, surface, the shape, concentration, solubility, the generation of reactive oxygen species, on their antibacterial activity. It then explains the mechanisms of antimicrobial activity MO-NPs. By the end of the chapter the nanoformulations of main metal oxides: aluminum, calcium, magnesium, silver, zinc, iron, copper, and titanium are presented. A full discussion of the correlation between metal oxide properties and their mechanisms of action as antimicrobials is included.
PB  - Elsevier
T2  - Nanotoxicity - Prevention and Antibacterial Applications of Nanomaterials
T1  - Antibacterial activity of metal oxide nanoparticles
SP  - 241
EP  - 274
DO  - 10.1016/B978-0-12-819943-5.00011-7
ER  - 

@inbook{
author = "Stanić, Vojislav and Tanasković, Slađana",
year = "2020",
abstract = "Mortality rate caused by multidrug-resistant bacterial infection is reported to be considerably high in the world. This chapter introduces metal oxide nanoparticles (MO-NPs) as antimicrobial agents. It starts by presenting the effect of physicochemical properties of MO-NPs such as: chemical composition, particle size, surface, the shape, concentration, solubility, the generation of reactive oxygen species, on their antibacterial activity. It then explains the mechanisms of antimicrobial activity MO-NPs. By the end of the chapter the nanoformulations of main metal oxides: aluminum, calcium, magnesium, silver, zinc, iron, copper, and titanium are presented. A full discussion of the correlation between metal oxide properties and their mechanisms of action as antimicrobials is included.",
publisher = "Elsevier",
journal = "Nanotoxicity - Prevention and Antibacterial Applications of Nanomaterials",
booktitle = "Antibacterial activity of metal oxide nanoparticles",
pages = "241-274",
doi = "10.1016/B978-0-12-819943-5.00011-7"
}

Stanić, V.,& Tanasković, S.. (2020). Antibacterial activity of metal oxide nanoparticles. in Nanotoxicity - Prevention and Antibacterial Applications of Nanomaterials
Elsevier., 241-274.
https://doi.org/10.1016/B978-0-12-819943-5.00011-7

Stanić V, Tanasković S. Antibacterial activity of metal oxide nanoparticles. in Nanotoxicity - Prevention and Antibacterial Applications of Nanomaterials. 2020;:241-274.
doi:10.1016/B978-0-12-819943-5.00011-7 .

Stanić, Vojislav, Tanasković, Slađana, "Antibacterial activity of metal oxide nanoparticles" in Nanotoxicity - Prevention and Antibacterial Applications of Nanomaterials (2020):241-274,
https://doi.org/10.1016/B978-0-12-819943-5.00011-7 . .

TY  - JOUR
AU  - Dražić, Branka
AU  - Antonijević-Nikolić, Mirjana
AU  - Žižak, Željko
AU  - Tanasković, Slađana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3650
AB  - Two   new   complexes   with   the   general   formula [Cu2(L)tpmc](ClO4)3·nH2O  (tpmc  = N,N′,N′′,N′′′-tetrakis(2-pyridylmethyl)- -1,4,8,11-tetraazacyclotetradecane,  L  = N-methylglycine, n =  3;  L  = N,N- -dimethylglycine, n = 2) were isolated and their composition, some physical and  chemical  properties  and  geometries  were  proposed  based  on  elemental analysis (C, H, N), conductometric and magnetic measurements and spectro-scopic data (UV–Vis, FTIR). It is evident that the complexes are binuclear and an exo coordination mode of the macrocyclic ligand in the boat conformation was proposed. The co-ligands are coordinated as a bridge using both oxygen atoms of the OCO- group. The cytotoxic activity of Cu(II) complexes as well as  their  Co(II)  analogs,  the  starting  ligands  and  the  free  salts  were  tested against human cervix adenocarcinoma cell line (HeLa), human chronic myelo-genous leukemia cells (K562), human breast cancer cell line (MDA-MB-453), and a non-cancerous cell line, human embryonic lung fibroblast (MRC-5). The IC50 values for the Cu(II) complexes were from 21.6±0.04 to 66.1±0.8, and for the Co(II) analogs were within the range from 8.8±0.74 to 15.40±1.52. All four complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans.
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous
VL  - 85
IS  - 5
SP  - 637
EP  - 649
DO  - 10.2298/JSC190710088D
ER  - 

@article{
author = "Dražić, Branka and Antonijević-Nikolić, Mirjana and Žižak, Željko and Tanasković, Slađana",
year = "2020",
abstract = "Two   new   complexes   with   the   general   formula [Cu2(L)tpmc](ClO4)3·nH2O  (tpmc  = N,N′,N′′,N′′′-tetrakis(2-pyridylmethyl)- -1,4,8,11-tetraazacyclotetradecane,  L  = N-methylglycine, n =  3;  L  = N,N- -dimethylglycine, n = 2) were isolated and their composition, some physical and  chemical  properties  and  geometries  were  proposed  based  on  elemental analysis (C, H, N), conductometric and magnetic measurements and spectro-scopic data (UV–Vis, FTIR). It is evident that the complexes are binuclear and an exo coordination mode of the macrocyclic ligand in the boat conformation was proposed. The co-ligands are coordinated as a bridge using both oxygen atoms of the OCO- group. The cytotoxic activity of Cu(II) complexes as well as  their  Co(II)  analogs,  the  starting  ligands  and  the  free  salts  were  tested against human cervix adenocarcinoma cell line (HeLa), human chronic myelo-genous leukemia cells (K562), human breast cancer cell line (MDA-MB-453), and a non-cancerous cell line, human embryonic lung fibroblast (MRC-5). The IC50 values for the Cu(II) complexes were from 21.6±0.04 to 66.1±0.8, and for the Co(II) analogs were within the range from 8.8±0.74 to 15.40±1.52. All four complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous",
volume = "85",
number = "5",
pages = "637-649",
doi = "10.2298/JSC190710088D"
}

Dražić, B., Antonijević-Nikolić, M., Žižak, Ž.,& Tanasković, S.. (2020). Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 85(5), 637-649.
https://doi.org/10.2298/JSC190710088D

Dražić B, Antonijević-Nikolić M, Žižak Ž, Tanasković S. Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous. in Journal of the Serbian Chemical Society. 2020;85(5):637-649.
doi:10.2298/JSC190710088D .

Dražić, Branka, Antonijević-Nikolić, Mirjana, Žižak, Željko, Tanasković, Slađana, "Synthesis and characterization of copper(II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous" in Journal of the Serbian Chemical Society, 85, no. 5 (2020):637-649,
https://doi.org/10.2298/JSC190710088D . .

TY  - JOUR
AU  - Antonijević-Nikolić, Mirjana
AU  - Antić-Stanković, Jelena
AU  - Dražić, Branka
AU  - Tanasković, Slađana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3336
AB  - New cationic mixed-ligand tetranuclear complex [Cu-4(tpht) (tpmc)(2)](ClO4)(6)center dot 5H(2)O (tpmc = N, N', N '', N"'-tetrakis-(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane, H(2)tpht - terephthalic acid (benzene-1,4-dicarboxylic acid)) was prepared and characterized by elemental analysis (C, H, N, Cu), UV/Vis, IR, EPR (X-band) spectra, conductivity, cyclic voltammetry and magnetic measurements (SQUID). Five coordinated geometry for new Cu(II) complex is proposed. The central metal ion is coordinated with two pyridyl and two cyclam nitrogens and bridged with -N-(CH2)(3)-N- fragments of the cyclam ring and OCO- of the terephthalate anion. Copper (II) ions are coordinated out of cyclam rings and one OCO- group from tpht bridges two Cu(II) inside tpmc unit and two Cu(2)tpmc units are bridged by dicarboxylate tpht dianion engaging all four oxygen atoms. Weak ferromagnetic interaction between copper (II) ions in new tetranuclear complex is observed, Weiss constant theta = 0.21 K and C = 0.398 cm(3) Kmol(-1). The new complex, related Cu(II) complexes with bridged benzene carboxylate, [Cu-2(C6H5COO)tpmc](ClO4)(3)center dot CH3OH, [Cu-2(Hpht)tpmc](ClO4)(3)center dot 3H(2)O (H(2)pht = phthalic acid), [Cu-4(ipht) (tpmc)(2)](ClO4)(6)center dot NaClO4 center dot 2CH(3)CN (H(2)ipht = isophthalic acid), solvents, starting salts and ligands were in vitro evaluated for antiproliferative and antibacterial activity. Antiproliferative evaluation was carried out using tumour cell lines: HeLa (human adenocarcinoma) and K562 (chronic myelogenous leukaemia). Among all tested compounds, the ipht complex revealed the highest antiproliferative activity. According to antibacterial screening results, most active compound was the benzoate complex against Micrococcus lysodeikticus.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Molecular Structure
T1  - New macrocyclic Cu(II) complex with bridge terephthalate: Synthesis, spectral properties, in vitro cytotoxic and antimicrobial activity. Comparison with related complexes
VL  - 1184
SP  - 41
EP  - 48
DO  - 10.1016/j.molstruc.2018.10.027
ER  - 

@article{
author = "Antonijević-Nikolić, Mirjana and Antić-Stanković, Jelena and Dražić, Branka and Tanasković, Slađana",
year = "2019",
abstract = "New cationic mixed-ligand tetranuclear complex [Cu-4(tpht) (tpmc)(2)](ClO4)(6)center dot 5H(2)O (tpmc = N, N', N '', N"'-tetrakis-(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane, H(2)tpht - terephthalic acid (benzene-1,4-dicarboxylic acid)) was prepared and characterized by elemental analysis (C, H, N, Cu), UV/Vis, IR, EPR (X-band) spectra, conductivity, cyclic voltammetry and magnetic measurements (SQUID). Five coordinated geometry for new Cu(II) complex is proposed. The central metal ion is coordinated with two pyridyl and two cyclam nitrogens and bridged with -N-(CH2)(3)-N- fragments of the cyclam ring and OCO- of the terephthalate anion. Copper (II) ions are coordinated out of cyclam rings and one OCO- group from tpht bridges two Cu(II) inside tpmc unit and two Cu(2)tpmc units are bridged by dicarboxylate tpht dianion engaging all four oxygen atoms. Weak ferromagnetic interaction between copper (II) ions in new tetranuclear complex is observed, Weiss constant theta = 0.21 K and C = 0.398 cm(3) Kmol(-1). The new complex, related Cu(II) complexes with bridged benzene carboxylate, [Cu-2(C6H5COO)tpmc](ClO4)(3)center dot CH3OH, [Cu-2(Hpht)tpmc](ClO4)(3)center dot 3H(2)O (H(2)pht = phthalic acid), [Cu-4(ipht) (tpmc)(2)](ClO4)(6)center dot NaClO4 center dot 2CH(3)CN (H(2)ipht = isophthalic acid), solvents, starting salts and ligands were in vitro evaluated for antiproliferative and antibacterial activity. Antiproliferative evaluation was carried out using tumour cell lines: HeLa (human adenocarcinoma) and K562 (chronic myelogenous leukaemia). Among all tested compounds, the ipht complex revealed the highest antiproliferative activity. According to antibacterial screening results, most active compound was the benzoate complex against Micrococcus lysodeikticus.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Molecular Structure",
title = "New macrocyclic Cu(II) complex with bridge terephthalate: Synthesis, spectral properties, in vitro cytotoxic and antimicrobial activity. Comparison with related complexes",
volume = "1184",
pages = "41-48",
doi = "10.1016/j.molstruc.2018.10.027"
}

Antonijević-Nikolić, M., Antić-Stanković, J., Dražić, B.,& Tanasković, S.. (2019). New macrocyclic Cu(II) complex with bridge terephthalate: Synthesis, spectral properties, in vitro cytotoxic and antimicrobial activity. Comparison with related complexes. in Journal of Molecular Structure
Elsevier Science BV, Amsterdam., 1184, 41-48.
https://doi.org/10.1016/j.molstruc.2018.10.027

Antonijević-Nikolić M, Antić-Stanković J, Dražić B, Tanasković S. New macrocyclic Cu(II) complex with bridge terephthalate: Synthesis, spectral properties, in vitro cytotoxic and antimicrobial activity. Comparison with related complexes. in Journal of Molecular Structure. 2019;1184:41-48.
doi:10.1016/j.molstruc.2018.10.027 .

Antonijević-Nikolić, Mirjana, Antić-Stanković, Jelena, Dražić, Branka, Tanasković, Slađana, "New macrocyclic Cu(II) complex with bridge terephthalate: Synthesis, spectral properties, in vitro cytotoxic and antimicrobial activity. Comparison with related complexes" in Journal of Molecular Structure, 1184 (2019):41-48,
https://doi.org/10.1016/j.molstruc.2018.10.027 . .

TY  - JOUR
AU  - Antonijević Nikolić, Mirjana
AU  - Dražić, Branka
AU  - Antić-Stanković, Jelena
AU  - Tanasković, Slađana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4379
AB  - New carboxylate complexes of the tetraazamacrocyclic ligand
N,N',N'',N'''-tetrakis(2-pyridilmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc)
with Ni(II) and Zn(II) as central ions were prepared. In mixed-ligand com-
plexes (endo,endo)-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate dianion (C9H8O42-
)
is also coordinated to metal ions. The complexes were characterized by ele-
mental analysis (C, H, N), FTIR and UV–Vis spectroscopy, molar conductivity
determination and magnetic susceptibility measurement at room temperature.
The analytical data of the complexes show the formation of binuclear
[Ni2(C9H8O4)tpmc](ClO4)2·4H2O and tetranuclear [Zn4(C9H8O4)(tpmc)2](ClO4)6·
·CH3CN·KClO 4·4H2O complexes. In tetranuclear Zn(II) complex bicyclic
dicarboxylate ligand is most likely to be bridge coordinated, and in binuclear
Ni(II) complex it is coordinated in a combined bridged manner with chelate
rings formation. In both complexes macrocyclic ligand was exo coordinated,
out of cyclam ring and adopts a boat conformation. The Zn(II) complex is one
of the rare tetranuclear Zn(II)-tpmc complexes with carboxylate ion bridging
two Zn2tpmc units. The complexes were tested for antibacterial activity against
Gram-positive bacteria Staphylococcus aureus (ATCC 25923) and Bacillus
subtilis (ATCC 6633), Gram-negative bacterium Escherichia coli (ATCC
25922), and yeast Candida albicans (ATCC 10231), and were screened for
antiproliferative activity against human cervix adenocarcinoma (HeLa) and
human myelogenous leukemia (K562) cell lines.
AB  - Синтетисани су нови карбоксилато комплекси са тетраазамакроцикличним ли-
гандом N,N',N'',N'''-тетракис(2-пиридилметил)-1,4,8,11-тетраазациклотетрадеканом
(tpmc) и Ni(II) и Zn(II) као централним јонима. У мешовитолигандним комплексима
(endo,endo)-бицикло-[2.2.1]-хепт-5-ен-2,3-дикарбоксилато дианјон (C9H8O4
2-
) је такође
везан за метални јон. Комплекси су окарактерисани елементалном анализом (C, H, N),
FTIR и UV/Vis спектроскопијом, као и мерењем моларне проводљивости и магнетне
сусцептибилности на собној температури. На основу добијених резултата претпос-
тављена је бинуклеарна структура [Ni2(C9H8O4)tpmc](ClO4) 2·4H2O комплекса, односно,
тетрануклеарна [Zn4(C9H8O4 )(tpmc) 2](ClO4)6·CH3CN·KClO4 ·4H2O комплекса. У тетра-
нуклеарном Zn(II) комплексу, бициклични дикарбоксилато лиганд је највероватније
мостно везан, док је у бинуклеарном Ni(II) комплексу мешовити мостно-хелатни начин
координације. Други начини мостног везивања дикарбоксилата не могу бити у потпуности искључени. У оба комплекса макроциклични лиганд је егзо координован, изван
цикламовог прстена и заузима конформацију лађе. Добијени Zn(II) кoмплекс је један од
ретких тетрануклеарних Zn(II)–tpmc комплекса са карбоксилато лигандом у мосту
између две Zn2tpmc јединице. Добијени комплекси су тестирани на антибактеријску
активност према Грам-позитивним бактеријама Staphylococcus aureus (ATCC 25923) и
Bacillus subtilis (ATCC 6633), Грам-негативној бактерији Escherichia coli (ATCC 25922) и
квасцу Candida albicans (ATCC 10231). Испитивана је њихова антипролиферативна
активност на хуманим малигним ћелијским линијама: цервикалног аденокарцинома
(HeLa) и мијелогене леукемије (K562).
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - New mixed-ligand Ni(II) and Zn(II) macrocyclic complexes with bridged bicyclo-[2,2,1]-hept-5-en-endo-2,3-cis-dicarboxylate: synthesis, characterization, antimicrobial and cytotoxic activity
T1  - Nови мешовитолигандни макроциклични комплекси Ni(II) и Zn(II) са мостовним (endo,endo)-бицикло-[2.2.1]-хепт-5-ен-2,3-дикарбоксилатом: синтеза, карактеризација, антимикробна и цитотоксична активност
VL  - 84
IS  - 9
SP  - 961
EP  - 973
DO  - https://doi.org/10.2298/JSC181216028A
ER  - 

@article{
author = "Antonijević Nikolić, Mirjana and Dražić, Branka and Antić-Stanković, Jelena and Tanasković, Slađana",
year = "2019",
abstract = "New carboxylate complexes of the tetraazamacrocyclic ligand
N,N',N'',N'''-tetrakis(2-pyridilmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc)
with Ni(II) and Zn(II) as central ions were prepared. In mixed-ligand com-
plexes (endo,endo)-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate dianion (C9H8O42-
)
is also coordinated to metal ions. The complexes were characterized by ele-
mental analysis (C, H, N), FTIR and UV–Vis spectroscopy, molar conductivity
determination and magnetic susceptibility measurement at room temperature.
The analytical data of the complexes show the formation of binuclear
[Ni2(C9H8O4)tpmc](ClO4)2·4H2O and tetranuclear [Zn4(C9H8O4)(tpmc)2](ClO4)6·
·CH3CN·KClO 4·4H2O complexes. In tetranuclear Zn(II) complex bicyclic
dicarboxylate ligand is most likely to be bridge coordinated, and in binuclear
Ni(II) complex it is coordinated in a combined bridged manner with chelate
rings formation. In both complexes macrocyclic ligand was exo coordinated,
out of cyclam ring and adopts a boat conformation. The Zn(II) complex is one
of the rare tetranuclear Zn(II)-tpmc complexes with carboxylate ion bridging
two Zn2tpmc units. The complexes were tested for antibacterial activity against
Gram-positive bacteria Staphylococcus aureus (ATCC 25923) and Bacillus
subtilis (ATCC 6633), Gram-negative bacterium Escherichia coli (ATCC
25922), and yeast Candida albicans (ATCC 10231), and were screened for
antiproliferative activity against human cervix adenocarcinoma (HeLa) and
human myelogenous leukemia (K562) cell lines., Синтетисани су нови карбоксилато комплекси са тетраазамакроцикличним ли-
гандом N,N',N'',N'''-тетракис(2-пиридилметил)-1,4,8,11-тетраазациклотетрадеканом
(tpmc) и Ni(II) и Zn(II) као централним јонима. У мешовитолигандним комплексима
(endo,endo)-бицикло-[2.2.1]-хепт-5-ен-2,3-дикарбоксилато дианјон (C9H8O4
2-
) је такође
везан за метални јон. Комплекси су окарактерисани елементалном анализом (C, H, N),
FTIR и UV/Vis спектроскопијом, као и мерењем моларне проводљивости и магнетне
сусцептибилности на собној температури. На основу добијених резултата претпос-
тављена је бинуклеарна структура [Ni2(C9H8O4)tpmc](ClO4) 2·4H2O комплекса, односно,
тетрануклеарна [Zn4(C9H8O4 )(tpmc) 2](ClO4)6·CH3CN·KClO4 ·4H2O комплекса. У тетра-
нуклеарном Zn(II) комплексу, бициклични дикарбоксилато лиганд је највероватније
мостно везан, док је у бинуклеарном Ni(II) комплексу мешовити мостно-хелатни начин
координације. Други начини мостног везивања дикарбоксилата не могу бити у потпуности искључени. У оба комплекса макроциклични лиганд је егзо координован, изван
цикламовог прстена и заузима конформацију лађе. Добијени Zn(II) кoмплекс је један од
ретких тетрануклеарних Zn(II)–tpmc комплекса са карбоксилато лигандом у мосту
између две Zn2tpmc јединице. Добијени комплекси су тестирани на антибактеријску
активност према Грам-позитивним бактеријама Staphylococcus aureus (ATCC 25923) и
Bacillus subtilis (ATCC 6633), Грам-негативној бактерији Escherichia coli (ATCC 25922) и
квасцу Candida albicans (ATCC 10231). Испитивана је њихова антипролиферативна
активност на хуманим малигним ћелијским линијама: цервикалног аденокарцинома
(HeLa) и мијелогене леукемије (K562).",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "New mixed-ligand Ni(II) and Zn(II) macrocyclic complexes with bridged bicyclo-[2,2,1]-hept-5-en-endo-2,3-cis-dicarboxylate: synthesis, characterization, antimicrobial and cytotoxic activity, Nови мешовитолигандни макроциклични комплекси Ni(II) и Zn(II) са мостовним (endo,endo)-бицикло-[2.2.1]-хепт-5-ен-2,3-дикарбоксилатом: синтеза, карактеризација, антимикробна и цитотоксична активност",
volume = "84",
number = "9",
pages = "961-973",
doi = "https://doi.org/10.2298/JSC181216028A"
}

Antonijević Nikolić, M., Dražić, B., Antić-Stanković, J.,& Tanasković, S.. (2019). New mixed-ligand Ni(II) and Zn(II) macrocyclic complexes with bridged bicyclo-[2,2,1]-hept-5-en-endo-2,3-cis-dicarboxylate: synthesis, characterization, antimicrobial and cytotoxic activity. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 84(9), 961-973.
https://doi.org/https://doi.org/10.2298/JSC181216028A

Antonijević Nikolić M, Dražić B, Antić-Stanković J, Tanasković S. New mixed-ligand Ni(II) and Zn(II) macrocyclic complexes with bridged bicyclo-[2,2,1]-hept-5-en-endo-2,3-cis-dicarboxylate: synthesis, characterization, antimicrobial and cytotoxic activity. in Journal of the Serbian Chemical Society. 2019;84(9):961-973.
doi:https://doi.org/10.2298/JSC181216028A .

Antonijević Nikolić, Mirjana, Dražić, Branka, Antić-Stanković, Jelena, Tanasković, Slađana, "New mixed-ligand Ni(II) and Zn(II) macrocyclic complexes with bridged bicyclo-[2,2,1]-hept-5-en-endo-2,3-cis-dicarboxylate: synthesis, characterization, antimicrobial and cytotoxic activity" in Journal of the Serbian Chemical Society, 84, no. 9 (2019):961-973,
https://doi.org/https://doi.org/10.2298/JSC181216028A . .

TY  - JOUR
AU  - Antonijević-Nikolić, Mirjana
AU  - Antić-Stanković, Jelena
AU  - Tanasković, Slađana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3083
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3426
AB  - AbstrcatNew cationic tetranuclear Co(II) and neutral binuclear Cu(II) complexes with tpmc (N,N,N,N-tetrakis-(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane) and bridging pyromellitate ligand pma (tetraanion 1,2,4,5-benzenetetracarboxylic acid) were isolated. The composition of the compounds is proposed based on elemental analyses (C, H, N, M=Cu, Co), molar conductivity determination, UV-Vis, FTIR, EPR, LC-MS and reflectance spectroscopy, magnetic measurements, cyclic voltammetry, as well as TG and DTA. It is proposed that in [Co-4(pma)(tpmc)(2)](ClO4)(4)6H(2)O (1), cobalt(II) is six-coordinate out of cyclam rings and one OCO- from pma participates in coordination with one Co(II). In the case of [Cu-2(pma)tpmc].8H(2)O (2), one OCO- from pma bridges two Cu(II). The cytotoxic activity of 1 and 2 was tested against tumor cell lines human cervix adenocarcinoma (HeLa), estrogen-receptor-positive human breast cancer (MCF-7), human myelogenous leukemia (K562), and the human Caucasian Burkitt's lymphoma (Ramos). The IC50 values for 1 and 2 were within the range 44.66 +/- 2.39 to 152.40 +/- 2.28M, and from 140.88 +/- 3.51 to 192.05 +/- 2.09M, respectively. Both 1 and 2 were tested for antimicrobial activity. We determined that minimal inhibitory concentration for 1 against Staphylococcus aureus, Bacillus subtilis, and Klebsiella pneumoniae was 25mM. Complex 2 did not express activity against tested microbial strains.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Coordination Chemistry
T1  - Synthesis, characterization, and in vitro antiproliferative and antibacterial studies of tetraazamacrocyclic complexes of Co(II) and Cu(II) with pyromellitic acid
VL  - 71
IS  - 10
SP  - 1542
EP  - 1559
DO  - 10.1080/00958972.2018.1459581
ER  - 

@article{
author = "Antonijević-Nikolić, Mirjana and Antić-Stanković, Jelena and Tanasković, Slađana",
year = "2018",
abstract = "AbstrcatNew cationic tetranuclear Co(II) and neutral binuclear Cu(II) complexes with tpmc (N,N,N,N-tetrakis-(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane) and bridging pyromellitate ligand pma (tetraanion 1,2,4,5-benzenetetracarboxylic acid) were isolated. The composition of the compounds is proposed based on elemental analyses (C, H, N, M=Cu, Co), molar conductivity determination, UV-Vis, FTIR, EPR, LC-MS and reflectance spectroscopy, magnetic measurements, cyclic voltammetry, as well as TG and DTA. It is proposed that in [Co-4(pma)(tpmc)(2)](ClO4)(4)6H(2)O (1), cobalt(II) is six-coordinate out of cyclam rings and one OCO- from pma participates in coordination with one Co(II). In the case of [Cu-2(pma)tpmc].8H(2)O (2), one OCO- from pma bridges two Cu(II). The cytotoxic activity of 1 and 2 was tested against tumor cell lines human cervix adenocarcinoma (HeLa), estrogen-receptor-positive human breast cancer (MCF-7), human myelogenous leukemia (K562), and the human Caucasian Burkitt's lymphoma (Ramos). The IC50 values for 1 and 2 were within the range 44.66 +/- 2.39 to 152.40 +/- 2.28M, and from 140.88 +/- 3.51 to 192.05 +/- 2.09M, respectively. Both 1 and 2 were tested for antimicrobial activity. We determined that minimal inhibitory concentration for 1 against Staphylococcus aureus, Bacillus subtilis, and Klebsiella pneumoniae was 25mM. Complex 2 did not express activity against tested microbial strains.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Coordination Chemistry",
title = "Synthesis, characterization, and in vitro antiproliferative and antibacterial studies of tetraazamacrocyclic complexes of Co(II) and Cu(II) with pyromellitic acid",
volume = "71",
number = "10",
pages = "1542-1559",
doi = "10.1080/00958972.2018.1459581"
}

Antonijević-Nikolić, M., Antić-Stanković, J.,& Tanasković, S.. (2018). Synthesis, characterization, and in vitro antiproliferative and antibacterial studies of tetraazamacrocyclic complexes of Co(II) and Cu(II) with pyromellitic acid. in Journal of Coordination Chemistry
Taylor & Francis Ltd, Abingdon., 71(10), 1542-1559.
https://doi.org/10.1080/00958972.2018.1459581

Antonijević-Nikolić M, Antić-Stanković J, Tanasković S. Synthesis, characterization, and in vitro antiproliferative and antibacterial studies of tetraazamacrocyclic complexes of Co(II) and Cu(II) with pyromellitic acid. in Journal of Coordination Chemistry. 2018;71(10):1542-1559.
doi:10.1080/00958972.2018.1459581 .

Antonijević-Nikolić, Mirjana, Antić-Stanković, Jelena, Tanasković, Slađana, "Synthesis, characterization, and in vitro antiproliferative and antibacterial studies of tetraazamacrocyclic complexes of Co(II) and Cu(II) with pyromellitic acid" in Journal of Coordination Chemistry, 71, no. 10 (2018):1542-1559,
https://doi.org/10.1080/00958972.2018.1459581 . .

TY  - JOUR
AU  - Antonijević-Nikolić, Mirjana
AU  - Antić-Stanković, Jelena
AU  - Tanasković, Slađana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3083
AB  - AbstrcatNew cationic tetranuclear Co(II) and neutral binuclear Cu(II) complexes with tpmc (N,N,N,N-tetrakis-(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane) and bridging pyromellitate ligand pma (tetraanion 1,2,4,5-benzenetetracarboxylic acid) were isolated. The composition of the compounds is proposed based on elemental analyses (C, H, N, M=Cu, Co), molar conductivity determination, UV-Vis, FTIR, EPR, LC-MS and reflectance spectroscopy, magnetic measurements, cyclic voltammetry, as well as TG and DTA. It is proposed that in [Co-4(pma)(tpmc)(2)](ClO4)(4)6H(2)O (1), cobalt(II) is six-coordinate out of cyclam rings and one OCO- from pma participates in coordination with one Co(II). In the case of [Cu-2(pma)tpmc].8H(2)O (2), one OCO- from pma bridges two Cu(II). The cytotoxic activity of 1 and 2 was tested against tumor cell lines human cervix adenocarcinoma (HeLa), estrogen-receptor-positive human breast cancer (MCF-7), human myelogenous leukemia (K562), and the human Caucasian Burkitt's lymphoma (Ramos). The IC50 values for 1 and 2 were within the range 44.66 +/- 2.39 to 152.40 +/- 2.28M, and from 140.88 +/- 3.51 to 192.05 +/- 2.09M, respectively. Both 1 and 2 were tested for antimicrobial activity. We determined that minimal inhibitory concentration for 1 against Staphylococcus aureus, Bacillus subtilis, and Klebsiella pneumoniae was 25mM. Complex 2 did not express activity against tested microbial strains.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Coordination Chemistry
T1  - Synthesis, characterization, and in vitro antiproliferative and antibacterial studies of tetraazamacrocyclic complexes of Co(II) and Cu(II) with pyromellitic acid
VL  - 71
IS  - 10
SP  - 1542
EP  - 1559
DO  - 10.1080/00958972.2018.1459581
ER  - 

@article{
author = "Antonijević-Nikolić, Mirjana and Antić-Stanković, Jelena and Tanasković, Slađana",
year = "2018",
abstract = "AbstrcatNew cationic tetranuclear Co(II) and neutral binuclear Cu(II) complexes with tpmc (N,N,N,N-tetrakis-(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane) and bridging pyromellitate ligand pma (tetraanion 1,2,4,5-benzenetetracarboxylic acid) were isolated. The composition of the compounds is proposed based on elemental analyses (C, H, N, M=Cu, Co), molar conductivity determination, UV-Vis, FTIR, EPR, LC-MS and reflectance spectroscopy, magnetic measurements, cyclic voltammetry, as well as TG and DTA. It is proposed that in [Co-4(pma)(tpmc)(2)](ClO4)(4)6H(2)O (1), cobalt(II) is six-coordinate out of cyclam rings and one OCO- from pma participates in coordination with one Co(II). In the case of [Cu-2(pma)tpmc].8H(2)O (2), one OCO- from pma bridges two Cu(II). The cytotoxic activity of 1 and 2 was tested against tumor cell lines human cervix adenocarcinoma (HeLa), estrogen-receptor-positive human breast cancer (MCF-7), human myelogenous leukemia (K562), and the human Caucasian Burkitt's lymphoma (Ramos). The IC50 values for 1 and 2 were within the range 44.66 +/- 2.39 to 152.40 +/- 2.28M, and from 140.88 +/- 3.51 to 192.05 +/- 2.09M, respectively. Both 1 and 2 were tested for antimicrobial activity. We determined that minimal inhibitory concentration for 1 against Staphylococcus aureus, Bacillus subtilis, and Klebsiella pneumoniae was 25mM. Complex 2 did not express activity against tested microbial strains.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Coordination Chemistry",
title = "Synthesis, characterization, and in vitro antiproliferative and antibacterial studies of tetraazamacrocyclic complexes of Co(II) and Cu(II) with pyromellitic acid",
volume = "71",
number = "10",
pages = "1542-1559",
doi = "10.1080/00958972.2018.1459581"
}

Antonijević-Nikolić, M., Antić-Stanković, J.,& Tanasković, S.. (2018). Synthesis, characterization, and in vitro antiproliferative and antibacterial studies of tetraazamacrocyclic complexes of Co(II) and Cu(II) with pyromellitic acid. in Journal of Coordination Chemistry
Taylor & Francis Ltd, Abingdon., 71(10), 1542-1559.
https://doi.org/10.1080/00958972.2018.1459581

Antonijević-Nikolić M, Antić-Stanković J, Tanasković S. Synthesis, characterization, and in vitro antiproliferative and antibacterial studies of tetraazamacrocyclic complexes of Co(II) and Cu(II) with pyromellitic acid. in Journal of Coordination Chemistry. 2018;71(10):1542-1559.
doi:10.1080/00958972.2018.1459581 .

Antonijević-Nikolić, Mirjana, Antić-Stanković, Jelena, Tanasković, Slađana, "Synthesis, characterization, and in vitro antiproliferative and antibacterial studies of tetraazamacrocyclic complexes of Co(II) and Cu(II) with pyromellitic acid" in Journal of Coordination Chemistry, 71, no. 10 (2018):1542-1559,
https://doi.org/10.1080/00958972.2018.1459581 . .

TY  - JOUR
AU  - Tanasković, Slađana
AU  - Antonijević-Nikolić, Mirjana
AU  - Dražić, Branka
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3113
AB  - A new complexes with general formula [Co2(X)2tpmc](BF4)2·Y (X= F-, Y=CH3CN; X= Br-, Y= H2O; tpmc = N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane), were isolated and their composition, some of physical and chemical properties and their tentative geometries were evaluated based on: elemental analysis (C, H, N), conductometric and magnetic measurements, spectroscopic data (UV/Vis, IR) respectively. Then, we compared synthesized complexes with early described chloro analogous. Both complexes are binuclear with proposed chair conformation of macrocycle. Complex compounds were also preliminary assayed in vitro toward some Gram (+) and Gram (-) bacteria, fungi and mould together with the starting material for the synthesis (ligands, simple salts and solvents) as test substances. In some cases certain antimicrobial activity of the complexes was detected. Minimal inhibitory concentration suppressing the visible growth of bacteria was determined. Both investigated complexes showed a moderate activity against strains of bacteria and were inactive against the tested fungi and mould. Under the same conditions and applied the same concentration of the control group did not show activity.
AB  - Pripremlljena su dva nova kompleksa opšte formule [Co2(X)2tpmc](BF4)2·Y (X= F-, Y=CH3CN; X= Br-, Y= H2O; tpmc = N,N',N'',N'''-tetrakis(2-piridilmetil)-1,4,8,11- tetraazaciklotetradekan), čiji su sastav, neke fizičke i hemijske osobine kao i približne geometrije određene na osnovu elementalne analize (C, H, N), konduktometrijskih i magnetnih merenja i spektroskopskih podataka (UV/Vis, IR). Podaci su upoređeni sa ranije sintetisanim i opisanim hloro analogom. Oba nova kompleksa Co(II) su dinuklearna sa pretpostavljenom egzo koordinacijom makrocikla u konformaciji stolice. Kompleksi su preliminarno testirani na neke Gram (+), Gram (-) bakterije, plesni i kvasce zajedno sa startnim supstancama za sintezu (ligandima, prostim solima i rastvaračima) koje su služile kao test supstance. Određivana je minimalna inhibitorna koncentracija koja sprečava rast bakterija. U nekim slučajevima je nađena izvesna antimikrobna aktivnost. Oba kompleksa su pokazala aktivnost prema bakterijama ali su inaktivni prema gljivicama i kvascima dok je pod istim uslovima i istim primenjenim koncentracijama kontrolna grupa bila neaktivna.
PB  - Inženjersko društvo za koroziju, Beograd
T2  - Zaštita materijala
T1  - New mixed ligand Co(II) complexes: Synthesis, characterization and antimicrobial activity
T1  - Novi mešovito-ligandni kompleksi Co (II)- sinteza, karakterizacija i antimikrobna aktivnost
VL  - 59
IS  - 1
SP  - 51
EP  - 55
DO  - 10.5937/ZasMat1801051T
ER  - 

@article{
author = "Tanasković, Slađana and Antonijević-Nikolić, Mirjana and Dražić, Branka",
year = "2018",
abstract = "A new complexes with general formula [Co2(X)2tpmc](BF4)2·Y (X= F-, Y=CH3CN; X= Br-, Y= H2O; tpmc = N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane), were isolated and their composition, some of physical and chemical properties and their tentative geometries were evaluated based on: elemental analysis (C, H, N), conductometric and magnetic measurements, spectroscopic data (UV/Vis, IR) respectively. Then, we compared synthesized complexes with early described chloro analogous. Both complexes are binuclear with proposed chair conformation of macrocycle. Complex compounds were also preliminary assayed in vitro toward some Gram (+) and Gram (-) bacteria, fungi and mould together with the starting material for the synthesis (ligands, simple salts and solvents) as test substances. In some cases certain antimicrobial activity of the complexes was detected. Minimal inhibitory concentration suppressing the visible growth of bacteria was determined. Both investigated complexes showed a moderate activity against strains of bacteria and were inactive against the tested fungi and mould. Under the same conditions and applied the same concentration of the control group did not show activity., Pripremlljena su dva nova kompleksa opšte formule [Co2(X)2tpmc](BF4)2·Y (X= F-, Y=CH3CN; X= Br-, Y= H2O; tpmc = N,N',N'',N'''-tetrakis(2-piridilmetil)-1,4,8,11- tetraazaciklotetradekan), čiji su sastav, neke fizičke i hemijske osobine kao i približne geometrije određene na osnovu elementalne analize (C, H, N), konduktometrijskih i magnetnih merenja i spektroskopskih podataka (UV/Vis, IR). Podaci su upoređeni sa ranije sintetisanim i opisanim hloro analogom. Oba nova kompleksa Co(II) su dinuklearna sa pretpostavljenom egzo koordinacijom makrocikla u konformaciji stolice. Kompleksi su preliminarno testirani na neke Gram (+), Gram (-) bakterije, plesni i kvasce zajedno sa startnim supstancama za sintezu (ligandima, prostim solima i rastvaračima) koje su služile kao test supstance. Određivana je minimalna inhibitorna koncentracija koja sprečava rast bakterija. U nekim slučajevima je nađena izvesna antimikrobna aktivnost. Oba kompleksa su pokazala aktivnost prema bakterijama ali su inaktivni prema gljivicama i kvascima dok je pod istim uslovima i istim primenjenim koncentracijama kontrolna grupa bila neaktivna.",
publisher = "Inženjersko društvo za koroziju, Beograd",
journal = "Zaštita materijala",
title = "New mixed ligand Co(II) complexes: Synthesis, characterization and antimicrobial activity, Novi mešovito-ligandni kompleksi Co (II)- sinteza, karakterizacija i antimikrobna aktivnost",
volume = "59",
number = "1",
pages = "51-55",
doi = "10.5937/ZasMat1801051T"
}

Tanasković, S., Antonijević-Nikolić, M.,& Dražić, B.. (2018). New mixed ligand Co(II) complexes: Synthesis, characterization and antimicrobial activity. in Zaštita materijala
Inženjersko društvo za koroziju, Beograd., 59(1), 51-55.
https://doi.org/10.5937/ZasMat1801051T

Tanasković S, Antonijević-Nikolić M, Dražić B. New mixed ligand Co(II) complexes: Synthesis, characterization and antimicrobial activity. in Zaštita materijala. 2018;59(1):51-55.
doi:10.5937/ZasMat1801051T .

Tanasković, Slađana, Antonijević-Nikolić, Mirjana, Dražić, Branka, "New mixed ligand Co(II) complexes: Synthesis, characterization and antimicrobial activity" in Zaštita materijala, 59, no. 1 (2018):51-55,
https://doi.org/10.5937/ZasMat1801051T . .

TY  - JOUR
AU  - Tanasković, Slađana
AU  - Antonijević-Nikolić, Mirjana
AU  - Dražić, Branka
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2834
AB  - The aim of this paper is to compare the efficiency of some analogue of Co (II) and Cu (II) complexes to bacteria pathogenic to humans, which can contaminate vegetables and fruit at any stage of its production. The complexes of Cu(II) and Co(II) with N, N’, N’’, N’’’ - tetrakis (2-pyridylmethyl) -1,4,8,11-tetraazacyclotetradecane (tpmc) and various additional ligands were tested against Gram (+) and Gram (-) bacteria and some strains of fungi. As a control group the free salts of Co(II) and Cu(II) which were used as starting substances in the synthesis, as well as ligands and solvents were tested. The minimum inhibition concentrations suppressing the visible growth of bacteria (MIC) were also screened. Investigated complexes showed a moderate activity against strains of bacteria. Complexes of Co(II) generally showed higher activity then Cu(II) analogues. Under the same conditions and the same concentrations, the control group showed no activity. No compound showed antifungal activity.
AB  - Cilj ovog rada je poređenje efikasnosti nekih analognih kompleksa Co(II) i Cu(II) na bakterijske vrste patogene za čoveka koje mogu kontaminirati povrće i voće u bilo kojoj fazi njegove proizvodnje. Kompleksi Cu (II) i Co (II) sa N, N’, N’’, N’’’ - tetrakis (2-piridilmetil) -1,4,8,11-tetraazaciklotetradekanom (tpmc) i različitim dodatnim ligandima su testirani na Gram (+) i Gram (-) bakterije i neke sojeve gljiva. Kao kontrolna grupa su testirane i proste soli Co(II) i Cu(II) koje su korišćene kao polazne supstance u sintezi kao i ligandi i rastvarači. Određene su minimalne inhibitorne koncentracije (MIC) koje sprečavaju rast mikroorganizama. Ispitivani kompleksi pokazuju umerenu aktivnost prema sojevima bakterija. Kompleksi Co(II) su pokazali generalno već u aktivnost u odnosu na Cu (II) analoge. Pod istim uslovima i u primenjenim istim koncentracijama kontrolne grupe nisu pokazale aktivnost. Nijedno jedinjenje nije ispoljilo antigljivično dejstvo.
PB  - Univerzitet u Novom Sadu - Poljoprivredni fakultet - Departman za zaštitu bilja i životne sredine "dr Pavla Vukasovića", Novi Sad
T2  - Biljni lekar
T1  - Comparison of the antimicrobial activity of related Co(II)/Cu(II) complexes
T1  - Uporedni prikaz antimikrobne aktivnosti srodnih Co(II)/Cu(II) kompleksa
VL  - 45
IS  - 3
SP  - 321
EP  - 325
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2834
ER  - 

@article{
author = "Tanasković, Slađana and Antonijević-Nikolić, Mirjana and Dražić, Branka",
year = "2017",
abstract = "The aim of this paper is to compare the efficiency of some analogue of Co (II) and Cu (II) complexes to bacteria pathogenic to humans, which can contaminate vegetables and fruit at any stage of its production. The complexes of Cu(II) and Co(II) with N, N’, N’’, N’’’ - tetrakis (2-pyridylmethyl) -1,4,8,11-tetraazacyclotetradecane (tpmc) and various additional ligands were tested against Gram (+) and Gram (-) bacteria and some strains of fungi. As a control group the free salts of Co(II) and Cu(II) which were used as starting substances in the synthesis, as well as ligands and solvents were tested. The minimum inhibition concentrations suppressing the visible growth of bacteria (MIC) were also screened. Investigated complexes showed a moderate activity against strains of bacteria. Complexes of Co(II) generally showed higher activity then Cu(II) analogues. Under the same conditions and the same concentrations, the control group showed no activity. No compound showed antifungal activity., Cilj ovog rada je poređenje efikasnosti nekih analognih kompleksa Co(II) i Cu(II) na bakterijske vrste patogene za čoveka koje mogu kontaminirati povrće i voće u bilo kojoj fazi njegove proizvodnje. Kompleksi Cu (II) i Co (II) sa N, N’, N’’, N’’’ - tetrakis (2-piridilmetil) -1,4,8,11-tetraazaciklotetradekanom (tpmc) i različitim dodatnim ligandima su testirani na Gram (+) i Gram (-) bakterije i neke sojeve gljiva. Kao kontrolna grupa su testirane i proste soli Co(II) i Cu(II) koje su korišćene kao polazne supstance u sintezi kao i ligandi i rastvarači. Određene su minimalne inhibitorne koncentracije (MIC) koje sprečavaju rast mikroorganizama. Ispitivani kompleksi pokazuju umerenu aktivnost prema sojevima bakterija. Kompleksi Co(II) su pokazali generalno već u aktivnost u odnosu na Cu (II) analoge. Pod istim uslovima i u primenjenim istim koncentracijama kontrolne grupe nisu pokazale aktivnost. Nijedno jedinjenje nije ispoljilo antigljivično dejstvo.",
publisher = "Univerzitet u Novom Sadu - Poljoprivredni fakultet - Departman za zaštitu bilja i životne sredine "dr Pavla Vukasovića", Novi Sad",
journal = "Biljni lekar",
title = "Comparison of the antimicrobial activity of related Co(II)/Cu(II) complexes, Uporedni prikaz antimikrobne aktivnosti srodnih Co(II)/Cu(II) kompleksa",
volume = "45",
number = "3",
pages = "321-325",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2834"
}

Tanasković, S., Antonijević-Nikolić, M.,& Dražić, B.. (2017). Comparison of the antimicrobial activity of related Co(II)/Cu(II) complexes. in Biljni lekar
Univerzitet u Novom Sadu - Poljoprivredni fakultet - Departman za zaštitu bilja i životne sredine "dr Pavla Vukasovića", Novi Sad., 45(3), 321-325.
https://hdl.handle.net/21.15107/rcub_farfar_2834

Tanasković S, Antonijević-Nikolić M, Dražić B. Comparison of the antimicrobial activity of related Co(II)/Cu(II) complexes. in Biljni lekar. 2017;45(3):321-325.
https://hdl.handle.net/21.15107/rcub_farfar_2834 .

Tanasković, Slađana, Antonijević-Nikolić, Mirjana, Dražić, Branka, "Comparison of the antimicrobial activity of related Co(II)/Cu(II) complexes" in Biljni lekar, 45, no. 3 (2017):321-325,
https://hdl.handle.net/21.15107/rcub_farfar_2834 .

TY  - JOUR
AU  - Ćurčić, Marijana
AU  - Tanasković, Slađana
AU  - Stanković, Sanja
AU  - Janković, Saša
AU  - Antunović, Marko
AU  - Đorđević, Snežana
AU  - Kilibarda, Vesna
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2474
AB  - Background/Aim. Based on numerous studies in animals, the most prominent toxic effects of decabrominated di-phenyl ether (BDE-209) are observed in the liver, thyroid hormone homeostasis, reproductive and nervous systems. BDE-209 exhibits its toxic effects partly through the aryl hydrocarbon (Ah) receptor and consequent induction of hepatic microsomal enzymes. The aim of this study was to assess the hepatotoxic effect vs target tissue dose of BDE-209 in the subacutely orally exposed Wistar rats. Methods. Effects were examined on male Wistar rats, weighing 200-240 g, exposed to doses of 1,000, 2,000 or 4,000 mg BDE-209/kg body weight (bw)/day by gavage during 28 days. Animals were treated according to the decision of the Ethics Committee of the Military Medical Academy, No 9667-1/2011. Evaluation of the hepatotoxic effect was based on: relative liver weight water and food intake, biochemical parameters of liver function [aspartate amino transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gama glutamyl transferase (γ-GT)], and oxidative stress parameters in liver homogenates [malondialdehiyde (MDA), superoxide dismutase (SOD), -SH] and morphological and pathohistological changes in the liver. For the assessment of internal dose - response relationship, lower confidence limit of Benchmark dose (BMDL) of 5% or 10% i.e. BMDL5 or BMDL10, were calculated using PROAST software. Results. After the application of 1,000, 2,000 or 4,000 mg BDE-209/kg bw/day, the concentrations of BDE-209 measured in liver were 0.269, 0.569 and 0.859 mg/kg of liver wet weight, (ww) respectively. Internal doses correlated with external (r = 0.972; p  lt  0.05) according to equation: internal dose (mg BDE-209/kg of liver ww) = 0.0002 ' external dose (mg/kg bw/day) + 0.0622. Hepato-toxicity was demonstrated based on significant increase in AST and γ-GT activities and the degree of histopathological changes. The lowest BMDL5 of 0.07228 mg BDE-209/kg of liver ww, correlating to external dose of 39 mg/kg/day, indicated the increase of AST activity as the most sensitive biomarker of BDE-209 hepatotoxicity in subacutely ex-posed rats. Conclusion. The results of the present work add up to the issue of BDE-209 toxicity profile with a focus on relationship between internal dose and hepatotoxicity. Critical internal dose for the effect on AST of 0.07 mg/kg of liver ww, corresponding to external dose of 39 mg/kg/day, is the lowest dose ever observed among the studies on BDE-209 hepatotoxicity. For the persistent sub-stances with low absorption rate such as BDE-209, critical effect based on internal dose in majority of cases is considered as more precisely defined than the effect established based on external dose, particularly.
AB  - Uvod/Cilj. Prema podacima iz brojnih studija na životinjama, dekabromovani difeniletar (BDE-209) najznačajnije toksične efekte ispoljava na jetri, homeostazi hormona štitaste žlezde, reproduktivnom i nervnom sistemu. BDE-209 ispoljava toksične efekte delom preko receptora za aromatične ugljovodonike (Ah) i posledične indukcije mikrozomalnih enzima jetre. Cilj rada bio je procena hepatotoksičnog efekta u odnosu na dozu BDE-209 u ciljnom tkivu kod subakutno oralno eksponovanih Wistar pacova. Metode. Efekti su ispitivani na mužjacima Wistar pacova, mase 200-240 g, koji su putem oralne sonde primali doze od 1 000, 2 000 ili 4 000 mg BDE-209/kg telesne mase (tm) dan, tokom 28 dana. Životinje su tretirane u skladu sa odlukom Etičkog komiteta Vojnomedicinske akademije u Beogradu br. 9667-1/2011. Procena hepatotoksičnih efekata bazirana je na merenju relativne mase jetre, unosa vode i hrane, biohemijskih parametara funkcije jetre [aspartat aminotransferaza (AST), alanin amino-transferaza (ALT), alkalna fosfataza (ALP), gama glutamil transferaza (γ-GT)], parametara oksidativnog stresa u homogenatima jetre [malondialdehid (MDA), superoksid dizmutaza (SOD), -SH)] i morfoloških i histoloških promena na jetri. Za procenu odnosa interna doza - odgovor izračunavana je donja granica pouzdanosti granične Benchmark doze (BMDL) od 5% (BMDL5) ili 10% (BMDL10) primenom PROAST softvera. Rezultati. Koncentracije BDE-209 iznosile su 0,269, 0,569 i 0,859 mg/kg jetre nakon aplikacije 1 000, 2 000, odnosno 4 000 mg BDE-209/kg tm/dan. Interna doza u našoj studiji korelisala je sa eksternom dozom prema jednačini: interna doza (mg BDE-209/kg jetre) = 0,0002 ' eksterna doza (mg/kg tm/dan) + 0,0622 (r = 0,972; p  lt  0,05). Hepatotoksičnost je potvrđena na osnovu nalaza o povećanju aktivnosti enzima AST i γ-GT, kao i stepena patohistološkog oštećenja jetre. Najniža BMDL5 u eksperimentu od 0,07228 mg BDE-209/kg jetre, koja koreliše sa eksternom dozom od 39 mg/kg tm/dan izračunata je za aktivnost AST i ukazuje na to da je aktivnost AST ujedno i najosetljiviji biomarker hepatotoksičnosti BDE-209 kod subakutno eksponovanih pacova. Zaključak. Rezultati prezentovane studije daju doprinos pitanju toksikološkog profila BDE-209 sa fokusom na odnos između interne doze i hepatotoksičnih efekata. Kritična interna doza za efekat na AST od 0,07 mg/kg jetre, koja koreliše sa eksternom dozom od 39 mg/kg tm/dan, jeste ujedno i najniža kritična doza do sada definisana za hepatotoksične efekte BDE-209. Kritičan efekat koji se bazira na dozi u ciljnom tkivu u većini slučajeva može se smatrati preciznije definisanim od kritičnog efekta definisanog na bazi oralno primenjene doze, naročito za nedegradabilne supstance sa niskim stepenom apsorpcije, kao što je BDE-209.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats
T1  - Odnos hepatotoksičnosti i doze dekabromovanog difeniletra u ciljnom tkivu kod subakutno izloženih Wistar pacova
VL  - 72
IS  - 5
SP  - 405
EP  - 413
DO  - 10.2298/VSP1505405C
ER  - 

@article{
author = "Ćurčić, Marijana and Tanasković, Slađana and Stanković, Sanja and Janković, Saša and Antunović, Marko and Đorđević, Snežana and Kilibarda, Vesna and Vučinić, Slavica and Antonijević, Biljana",
year = "2015",
abstract = "Background/Aim. Based on numerous studies in animals, the most prominent toxic effects of decabrominated di-phenyl ether (BDE-209) are observed in the liver, thyroid hormone homeostasis, reproductive and nervous systems. BDE-209 exhibits its toxic effects partly through the aryl hydrocarbon (Ah) receptor and consequent induction of hepatic microsomal enzymes. The aim of this study was to assess the hepatotoxic effect vs target tissue dose of BDE-209 in the subacutely orally exposed Wistar rats. Methods. Effects were examined on male Wistar rats, weighing 200-240 g, exposed to doses of 1,000, 2,000 or 4,000 mg BDE-209/kg body weight (bw)/day by gavage during 28 days. Animals were treated according to the decision of the Ethics Committee of the Military Medical Academy, No 9667-1/2011. Evaluation of the hepatotoxic effect was based on: relative liver weight water and food intake, biochemical parameters of liver function [aspartate amino transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gama glutamyl transferase (γ-GT)], and oxidative stress parameters in liver homogenates [malondialdehiyde (MDA), superoxide dismutase (SOD), -SH] and morphological and pathohistological changes in the liver. For the assessment of internal dose - response relationship, lower confidence limit of Benchmark dose (BMDL) of 5% or 10% i.e. BMDL5 or BMDL10, were calculated using PROAST software. Results. After the application of 1,000, 2,000 or 4,000 mg BDE-209/kg bw/day, the concentrations of BDE-209 measured in liver were 0.269, 0.569 and 0.859 mg/kg of liver wet weight, (ww) respectively. Internal doses correlated with external (r = 0.972; p  lt  0.05) according to equation: internal dose (mg BDE-209/kg of liver ww) = 0.0002 ' external dose (mg/kg bw/day) + 0.0622. Hepato-toxicity was demonstrated based on significant increase in AST and γ-GT activities and the degree of histopathological changes. The lowest BMDL5 of 0.07228 mg BDE-209/kg of liver ww, correlating to external dose of 39 mg/kg/day, indicated the increase of AST activity as the most sensitive biomarker of BDE-209 hepatotoxicity in subacutely ex-posed rats. Conclusion. The results of the present work add up to the issue of BDE-209 toxicity profile with a focus on relationship between internal dose and hepatotoxicity. Critical internal dose for the effect on AST of 0.07 mg/kg of liver ww, corresponding to external dose of 39 mg/kg/day, is the lowest dose ever observed among the studies on BDE-209 hepatotoxicity. For the persistent sub-stances with low absorption rate such as BDE-209, critical effect based on internal dose in majority of cases is considered as more precisely defined than the effect established based on external dose, particularly., Uvod/Cilj. Prema podacima iz brojnih studija na životinjama, dekabromovani difeniletar (BDE-209) najznačajnije toksične efekte ispoljava na jetri, homeostazi hormona štitaste žlezde, reproduktivnom i nervnom sistemu. BDE-209 ispoljava toksične efekte delom preko receptora za aromatične ugljovodonike (Ah) i posledične indukcije mikrozomalnih enzima jetre. Cilj rada bio je procena hepatotoksičnog efekta u odnosu na dozu BDE-209 u ciljnom tkivu kod subakutno oralno eksponovanih Wistar pacova. Metode. Efekti su ispitivani na mužjacima Wistar pacova, mase 200-240 g, koji su putem oralne sonde primali doze od 1 000, 2 000 ili 4 000 mg BDE-209/kg telesne mase (tm) dan, tokom 28 dana. Životinje su tretirane u skladu sa odlukom Etičkog komiteta Vojnomedicinske akademije u Beogradu br. 9667-1/2011. Procena hepatotoksičnih efekata bazirana je na merenju relativne mase jetre, unosa vode i hrane, biohemijskih parametara funkcije jetre [aspartat aminotransferaza (AST), alanin amino-transferaza (ALT), alkalna fosfataza (ALP), gama glutamil transferaza (γ-GT)], parametara oksidativnog stresa u homogenatima jetre [malondialdehid (MDA), superoksid dizmutaza (SOD), -SH)] i morfoloških i histoloških promena na jetri. Za procenu odnosa interna doza - odgovor izračunavana je donja granica pouzdanosti granične Benchmark doze (BMDL) od 5% (BMDL5) ili 10% (BMDL10) primenom PROAST softvera. Rezultati. Koncentracije BDE-209 iznosile su 0,269, 0,569 i 0,859 mg/kg jetre nakon aplikacije 1 000, 2 000, odnosno 4 000 mg BDE-209/kg tm/dan. Interna doza u našoj studiji korelisala je sa eksternom dozom prema jednačini: interna doza (mg BDE-209/kg jetre) = 0,0002 ' eksterna doza (mg/kg tm/dan) + 0,0622 (r = 0,972; p  lt  0,05). Hepatotoksičnost je potvrđena na osnovu nalaza o povećanju aktivnosti enzima AST i γ-GT, kao i stepena patohistološkog oštećenja jetre. Najniža BMDL5 u eksperimentu od 0,07228 mg BDE-209/kg jetre, koja koreliše sa eksternom dozom od 39 mg/kg tm/dan izračunata je za aktivnost AST i ukazuje na to da je aktivnost AST ujedno i najosetljiviji biomarker hepatotoksičnosti BDE-209 kod subakutno eksponovanih pacova. Zaključak. Rezultati prezentovane studije daju doprinos pitanju toksikološkog profila BDE-209 sa fokusom na odnos između interne doze i hepatotoksičnih efekata. Kritična interna doza za efekat na AST od 0,07 mg/kg jetre, koja koreliše sa eksternom dozom od 39 mg/kg tm/dan, jeste ujedno i najniža kritična doza do sada definisana za hepatotoksične efekte BDE-209. Kritičan efekat koji se bazira na dozi u ciljnom tkivu u većini slučajeva može se smatrati preciznije definisanim od kritičnog efekta definisanog na bazi oralno primenjene doze, naročito za nedegradabilne supstance sa niskim stepenom apsorpcije, kao što je BDE-209.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats, Odnos hepatotoksičnosti i doze dekabromovanog difeniletra u ciljnom tkivu kod subakutno izloženih Wistar pacova",
volume = "72",
number = "5",
pages = "405-413",
doi = "10.2298/VSP1505405C"
}

Ćurčić, M., Tanasković, S., Stanković, S., Janković, S., Antunović, M., Đorđević, S., Kilibarda, V., Vučinić, S.,& Antonijević, B.. (2015). Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 72(5), 405-413.
https://doi.org/10.2298/VSP1505405C

Ćurčić M, Tanasković S, Stanković S, Janković S, Antunović M, Đorđević S, Kilibarda V, Vučinić S, Antonijević B. Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats. in Vojnosanitetski pregled. 2015;72(5):405-413.
doi:10.2298/VSP1505405C .

Ćurčić, Marijana, Tanasković, Slađana, Stanković, Sanja, Janković, Saša, Antunović, Marko, Đorđević, Snežana, Kilibarda, Vesna, Vučinić, Slavica, Antonijević, Biljana, "Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats" in Vojnosanitetski pregled, 72, no. 5 (2015):405-413,
https://doi.org/10.2298/VSP1505405C . .

TY  - JOUR
AU  - Stanić, Vojislav
AU  - Dimitrijević, Suzana
AU  - Antonović, Dušan G.
AU  - Jokić, Bojan
AU  - Zec, Slavica P.
AU  - Tanasković, Slađana
AU  - Raičević, Slavica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2187
AB  - Synthetic biomaterials based on fluorine substituted hydroxyapatite are potentially attractive for orthopedic and dental implant applications. The new synthesis of fluorine substituted hydroxyapatite samples were done by neutralization, which consists of adding the solution of HF and H3PO4 in suspension of Ca(OH)(2). Characterization studies from XRD, SEM and FTIR spectra showed that crystals are obtained with apatite structure and those particles of all samples are nano size, with an average length of 80 nm and about 15-25 nm in diameter. The central composite design was used in order to determine the optimal conditions for the antimicrobial activity of the synthesized samples. In order to evaluate the influence of operating parameters on the percent of viable cell reduction of Streptococcus mutans, three independent variables were chosen: exposure time, pH of saline and floride concentration in apatite samples. The experimental and predicted antimicrobial activities were in close agreement. Antimicrobial activity of the samples increases with the increase of fluoride concentration and the decreased pH of saline. The maximum antimicrobial activity was achieved at the initial pH of 4.
PB  - Elsevier Science BV, Amsterdam
T2  - Applied Surface Science
T1  - Synthesis of fluorine substituted hydroxyapatite nanopowders and application of the central composite design for determination of its antimicrobial effects
VL  - 290
SP  - 346
EP  - 352
DO  - 10.1016/j.apsusc.2013.11.081
ER  - 

@article{
author = "Stanić, Vojislav and Dimitrijević, Suzana and Antonović, Dušan G. and Jokić, Bojan and Zec, Slavica P. and Tanasković, Slađana and Raičević, Slavica",
year = "2014",
abstract = "Synthetic biomaterials based on fluorine substituted hydroxyapatite are potentially attractive for orthopedic and dental implant applications. The new synthesis of fluorine substituted hydroxyapatite samples were done by neutralization, which consists of adding the solution of HF and H3PO4 in suspension of Ca(OH)(2). Characterization studies from XRD, SEM and FTIR spectra showed that crystals are obtained with apatite structure and those particles of all samples are nano size, with an average length of 80 nm and about 15-25 nm in diameter. The central composite design was used in order to determine the optimal conditions for the antimicrobial activity of the synthesized samples. In order to evaluate the influence of operating parameters on the percent of viable cell reduction of Streptococcus mutans, three independent variables were chosen: exposure time, pH of saline and floride concentration in apatite samples. The experimental and predicted antimicrobial activities were in close agreement. Antimicrobial activity of the samples increases with the increase of fluoride concentration and the decreased pH of saline. The maximum antimicrobial activity was achieved at the initial pH of 4.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Applied Surface Science",
title = "Synthesis of fluorine substituted hydroxyapatite nanopowders and application of the central composite design for determination of its antimicrobial effects",
volume = "290",
pages = "346-352",
doi = "10.1016/j.apsusc.2013.11.081"
}

Stanić, V., Dimitrijević, S., Antonović, D. G., Jokić, B., Zec, S. P., Tanasković, S.,& Raičević, S.. (2014). Synthesis of fluorine substituted hydroxyapatite nanopowders and application of the central composite design for determination of its antimicrobial effects. in Applied Surface Science
Elsevier Science BV, Amsterdam., 290, 346-352.
https://doi.org/10.1016/j.apsusc.2013.11.081

Stanić V, Dimitrijević S, Antonović DG, Jokić B, Zec SP, Tanasković S, Raičević S. Synthesis of fluorine substituted hydroxyapatite nanopowders and application of the central composite design for determination of its antimicrobial effects. in Applied Surface Science. 2014;290:346-352.
doi:10.1016/j.apsusc.2013.11.081 .

Stanić, Vojislav, Dimitrijević, Suzana, Antonović, Dušan G., Jokić, Bojan, Zec, Slavica P., Tanasković, Slađana, Raičević, Slavica, "Synthesis of fluorine substituted hydroxyapatite nanopowders and application of the central composite design for determination of its antimicrobial effects" in Applied Surface Science, 290 (2014):346-352,
https://doi.org/10.1016/j.apsusc.2013.11.081 . .

TY  - JOUR
AU  - Tanasković, Slađana
AU  - Antonijević-Nikolić, Mirjana
AU  - Hollo, Berta Barta
AU  - Dražić, Branka
AU  - Stanojković, Tatjana
AU  - Meszaros-Szecsenyi, Katalin
AU  - Vucković, Gordana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2131
AB  - Seven macrocyclic dinuclear Cu(II) complexes with tpmc = = N,N ',N '',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane of coordination formulae [Cu(2)tpmc](ClO4)(4) (1), [Cu-2(X)tpmc](ClO4)(3)center dot nH(2)O, X= F-, n = 0 (2), X = Cl-, n = 1 (3), X = Br-, n = 0 (4), X= I-, n = 1 (5), X = = NO2-, n = 0 (6), [Cu-2(NCS)(2)tpmc](ClO4)(2) (7) were evaluated for their cytotoxic activity against human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The results were compared with the corresponding data for the cis-diamminedichloridoplafinum(H) (CDDP) as referent cytostatic, as well as with the free ligands and the solvent dimethyl sulfoxide (DMSO) as controls. The complexes showed considerable antiproliferative effect, although significantly less than CDDP. The thermal decomposition pattern of the complexes was determined by simultaneous TG/DSC measurements. The thermal stability of the compounds 2-7 followed the trend of their antiproliferative activity against the HeLa cell line, as well as their corresponding stability constants. The highest thermal stability and cytotoxicity belonged to complex [Cu(2)tpmc](ClO4)(4), with no anionic co-ligand. Complex [Cu-2(NO2)tpmc](ClO4)(3) exhibited a selective cytotoxicity against LS174 cells, at the level of the most active [Cu(2)tpmc](ClO4)(4).
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes
VL  - 79
IS  - 10
SP  - 1235
EP  - 1247
DO  - 10.2298/JSC140404044T
ER  - 

@article{
author = "Tanasković, Slađana and Antonijević-Nikolić, Mirjana and Hollo, Berta Barta and Dražić, Branka and Stanojković, Tatjana and Meszaros-Szecsenyi, Katalin and Vucković, Gordana",
year = "2014",
abstract = "Seven macrocyclic dinuclear Cu(II) complexes with tpmc = = N,N ',N '',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane of coordination formulae [Cu(2)tpmc](ClO4)(4) (1), [Cu-2(X)tpmc](ClO4)(3)center dot nH(2)O, X= F-, n = 0 (2), X = Cl-, n = 1 (3), X = Br-, n = 0 (4), X= I-, n = 1 (5), X = = NO2-, n = 0 (6), [Cu-2(NCS)(2)tpmc](ClO4)(2) (7) were evaluated for their cytotoxic activity against human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The results were compared with the corresponding data for the cis-diamminedichloridoplafinum(H) (CDDP) as referent cytostatic, as well as with the free ligands and the solvent dimethyl sulfoxide (DMSO) as controls. The complexes showed considerable antiproliferative effect, although significantly less than CDDP. The thermal decomposition pattern of the complexes was determined by simultaneous TG/DSC measurements. The thermal stability of the compounds 2-7 followed the trend of their antiproliferative activity against the HeLa cell line, as well as their corresponding stability constants. The highest thermal stability and cytotoxicity belonged to complex [Cu(2)tpmc](ClO4)(4), with no anionic co-ligand. Complex [Cu-2(NO2)tpmc](ClO4)(3) exhibited a selective cytotoxicity against LS174 cells, at the level of the most active [Cu(2)tpmc](ClO4)(4).",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes",
volume = "79",
number = "10",
pages = "1235-1247",
doi = "10.2298/JSC140404044T"
}

Tanasković, S., Antonijević-Nikolić, M., Hollo, B. B., Dražić, B., Stanojković, T., Meszaros-Szecsenyi, K.,& Vucković, G.. (2014). Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 79(10), 1235-1247.
https://doi.org/10.2298/JSC140404044T

Tanasković S, Antonijević-Nikolić M, Hollo BB, Dražić B, Stanojković T, Meszaros-Szecsenyi K, Vucković G. Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes. in Journal of the Serbian Chemical Society. 2014;79(10):1235-1247.
doi:10.2298/JSC140404044T .

Tanasković, Slađana, Antonijević-Nikolić, Mirjana, Hollo, Berta Barta, Dražić, Branka, Stanojković, Tatjana, Meszaros-Szecsenyi, Katalin, Vucković, Gordana, "Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes" in Journal of the Serbian Chemical Society, 79, no. 10 (2014):1235-1247,
https://doi.org/10.2298/JSC140404044T . .

TY  - JOUR
AU  - Tanasković, Slađana
AU  - Antić-Stanković, Jelena
AU  - Antonijević-Nikolić, Mirjana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2039
AB  - Four cationic mixed-ligand complexes of Cu (II) with N, N', N'', N''' -tetrakis (2-pyridylmethyl) -1,4,8,11 -tetraazacyclotetradecane (tpmc) and aliphatic dicarboxylic acids: succinic, glutaric , adipic and sebacic were investigated in vitro on the human cervix adenocarcinoma (HeLa), human malignant melanoma (Fem-x), oestrogen-receptor-positive human breast cancer (MCF-7) cells and the human acute monocyte leukemia cell line (THP1), while free ligands, Cu(II) salt and solvent (used as a controls) were inactive on the same conditions. The metabolic activity of the cells was determined by tetrazolium MTS test. All complexes showed cytotoxicity toward the used cell lines, while free ligands, Cu(II) salt and solvent (used as a controls) were inactive on the same conditions. Increasing the number of - CH2- groups in homologous serie of aliphatic dicarboxylate ligands leads to the increasing cytotoxic activity of the complex. The highest cytotoxic effect of azamacrocycle Cu(II) complexes with glutarate, adipate, sebacinate ligand showed on the cell line MCF-7 and the worst on HeLa cells. A significant effect of sebacinate Cu(II)complex to all tested tumor cell lines applied in concentrations of 100 and 200 μM and up to HeLa cells.
AB  - Četiri katjonska mešovito-ligandna kompleksa Cu(II) sa N,N',N'N''-tetrakis(2- piridilmetil)-1,4,8,11-tetraaza-ciklotetradekanom i alifatičnim dikarboksilatima: ćilibarnom, glutarnom, adipinskom i sebacinskom kiselinom su ispitivani na humanim malignim ćelijskim linijama: cervikalnog adenokarcinoma (HeLa), melanoma (Fem-X), estrogen pozitivnog karcinoma dojke (MCF-7) i akutne monocitne leukemjie (THP1). Uporedo su testirani i sami ligandi, proste soli i rastvarači. Metabolička aktivnost ćelija je određena MTS testom. Svi ispitivani kompleksi su pokazali citotoksični efekat prema testiranim ćelijskim linijama, dok su slobodni ligandi, Cu(II) so i rastvarač (koji su korišćeni kao kontrolni) pod istim uslovima, bili neaktivni. Sa povećanjem broja -CH2- grupa homologog niza alifatičnih dikarboksilato liganada dolazi i do povećane citotoksičnosti kompleksa. Najveći citotoksični efekat su pokazali makrociklični Cu(II) kompleksi sa glutarato, adipato i sebacinato ligandima prema MCF-7, a najslabiji prema HeLa ćelijama. Najveći antiproliferativni efekat pokazuje kompleks sa sebacinato ligandom prema svim testiranim linijama tumorskih ćelija u primenjenim koncentracijama od 100 i 200 μM, a najviše prema HeLa ćelijama.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Antiproliferative activity of mixed-ligand Cu(II) complexes with pendant octaazamacrocycle in vitro
T1  - Antiproliferativna aktivnost mešovito-ligandnih Cu (II) kompleksa sa pendantnim oktaazamakrociklom in vitro
VL  - 63
IS  - 4
SP  - 365
EP  - 374
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2039
ER  - 

@article{
author = "Tanasković, Slađana and Antić-Stanković, Jelena and Antonijević-Nikolić, Mirjana",
year = "2013",
abstract = "Four cationic mixed-ligand complexes of Cu (II) with N, N', N'', N''' -tetrakis (2-pyridylmethyl) -1,4,8,11 -tetraazacyclotetradecane (tpmc) and aliphatic dicarboxylic acids: succinic, glutaric , adipic and sebacic were investigated in vitro on the human cervix adenocarcinoma (HeLa), human malignant melanoma (Fem-x), oestrogen-receptor-positive human breast cancer (MCF-7) cells and the human acute monocyte leukemia cell line (THP1), while free ligands, Cu(II) salt and solvent (used as a controls) were inactive on the same conditions. The metabolic activity of the cells was determined by tetrazolium MTS test. All complexes showed cytotoxicity toward the used cell lines, while free ligands, Cu(II) salt and solvent (used as a controls) were inactive on the same conditions. Increasing the number of - CH2- groups in homologous serie of aliphatic dicarboxylate ligands leads to the increasing cytotoxic activity of the complex. The highest cytotoxic effect of azamacrocycle Cu(II) complexes with glutarate, adipate, sebacinate ligand showed on the cell line MCF-7 and the worst on HeLa cells. A significant effect of sebacinate Cu(II)complex to all tested tumor cell lines applied in concentrations of 100 and 200 μM and up to HeLa cells., Četiri katjonska mešovito-ligandna kompleksa Cu(II) sa N,N',N'N''-tetrakis(2- piridilmetil)-1,4,8,11-tetraaza-ciklotetradekanom i alifatičnim dikarboksilatima: ćilibarnom, glutarnom, adipinskom i sebacinskom kiselinom su ispitivani na humanim malignim ćelijskim linijama: cervikalnog adenokarcinoma (HeLa), melanoma (Fem-X), estrogen pozitivnog karcinoma dojke (MCF-7) i akutne monocitne leukemjie (THP1). Uporedo su testirani i sami ligandi, proste soli i rastvarači. Metabolička aktivnost ćelija je određena MTS testom. Svi ispitivani kompleksi su pokazali citotoksični efekat prema testiranim ćelijskim linijama, dok su slobodni ligandi, Cu(II) so i rastvarač (koji su korišćeni kao kontrolni) pod istim uslovima, bili neaktivni. Sa povećanjem broja -CH2- grupa homologog niza alifatičnih dikarboksilato liganada dolazi i do povećane citotoksičnosti kompleksa. Najveći citotoksični efekat su pokazali makrociklični Cu(II) kompleksi sa glutarato, adipato i sebacinato ligandima prema MCF-7, a najslabiji prema HeLa ćelijama. Najveći antiproliferativni efekat pokazuje kompleks sa sebacinato ligandom prema svim testiranim linijama tumorskih ćelija u primenjenim koncentracijama od 100 i 200 μM, a najviše prema HeLa ćelijama.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Antiproliferative activity of mixed-ligand Cu(II) complexes with pendant octaazamacrocycle in vitro, Antiproliferativna aktivnost mešovito-ligandnih Cu (II) kompleksa sa pendantnim oktaazamakrociklom in vitro",
volume = "63",
number = "4",
pages = "365-374",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2039"
}

Tanasković, S., Antić-Stanković, J.,& Antonijević-Nikolić, M.. (2013). Antiproliferative activity of mixed-ligand Cu(II) complexes with pendant octaazamacrocycle in vitro. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 63(4), 365-374.
https://hdl.handle.net/21.15107/rcub_farfar_2039

Tanasković S, Antić-Stanković J, Antonijević-Nikolić M. Antiproliferative activity of mixed-ligand Cu(II) complexes with pendant octaazamacrocycle in vitro. in Arhiv za farmaciju. 2013;63(4):365-374.
https://hdl.handle.net/21.15107/rcub_farfar_2039 .

Tanasković, Slađana, Antić-Stanković, Jelena, Antonijević-Nikolić, Mirjana, "Antiproliferative activity of mixed-ligand Cu(II) complexes with pendant octaazamacrocycle in vitro" in Arhiv za farmaciju, 63, no. 4 (2013):365-374,
https://hdl.handle.net/21.15107/rcub_farfar_2039 .

TY  - JOUR
AU  - Antonijević-Nikolić, Mirjana
AU  - Antić-Stanković, Jelena
AU  - Tanasković, Slađana
AU  - Korabik, Maria J.
AU  - Gojgić-Cvijović, Gordana
AU  - Vucković, Gordana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1907
AB  - New cationic Cu(II) complexes with N, N', N '', N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc) and aliphatic dicarboxylic acids: pentanedioic (glutaric acid = glutH(2)), hexanedioic acid (adipic acid = adipH(2)) and decanedioic acid (sebacic acid = sebH(2)) of general formula [Cu-4(L)(tpmc)(2)] (ClO4)(6)center dot xH(2)O, L = glut, x = 2; L = adip, x = 7; L = seb, x = 6 were isolated. Their composition and charges are proposed based on elemental analyses and molar conductivity measurements. By the comparison of their UV-Vis, reflectance, FTIR and EPR spectral data, CV and SQUID magnetic measurements, with those for the complex with butanedioic acid (succinic acid = succH(2)) of known molecular structure and analysis of LC/MS spectra, geometry with two [Cu(2)tpmc](4) units bridged by dicarboxylate dianion engaging all oxygens is proposed. Within units, Cu(II) ions are also bridged with -N- portion of cyclam ring. All four complexes were screened to in vitro antimicrobial and cytotoxic activity along with free primary and secondary ligands, Cu(II) salt and solvent controls. Detected antibacterial and cytotoxic activity for the complexes was enhanced in most cases than the corresponding controls.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Molecular Structure
T1  - Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes
VL  - 1054
SP  - 297
EP  - 306
DO  - 10.1016/j.molstruc.2013.10.006
ER  - 

@article{
author = "Antonijević-Nikolić, Mirjana and Antić-Stanković, Jelena and Tanasković, Slađana and Korabik, Maria J. and Gojgić-Cvijović, Gordana and Vucković, Gordana",
year = "2013",
abstract = "New cationic Cu(II) complexes with N, N', N '', N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc) and aliphatic dicarboxylic acids: pentanedioic (glutaric acid = glutH(2)), hexanedioic acid (adipic acid = adipH(2)) and decanedioic acid (sebacic acid = sebH(2)) of general formula [Cu-4(L)(tpmc)(2)] (ClO4)(6)center dot xH(2)O, L = glut, x = 2; L = adip, x = 7; L = seb, x = 6 were isolated. Their composition and charges are proposed based on elemental analyses and molar conductivity measurements. By the comparison of their UV-Vis, reflectance, FTIR and EPR spectral data, CV and SQUID magnetic measurements, with those for the complex with butanedioic acid (succinic acid = succH(2)) of known molecular structure and analysis of LC/MS spectra, geometry with two [Cu(2)tpmc](4) units bridged by dicarboxylate dianion engaging all oxygens is proposed. Within units, Cu(II) ions are also bridged with -N- portion of cyclam ring. All four complexes were screened to in vitro antimicrobial and cytotoxic activity along with free primary and secondary ligands, Cu(II) salt and solvent controls. Detected antibacterial and cytotoxic activity for the complexes was enhanced in most cases than the corresponding controls.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Molecular Structure",
title = "Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes",
volume = "1054",
pages = "297-306",
doi = "10.1016/j.molstruc.2013.10.006"
}

Antonijević-Nikolić, M., Antić-Stanković, J., Tanasković, S., Korabik, M. J., Gojgić-Cvijović, G.,& Vucković, G.. (2013). Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes. in Journal of Molecular Structure
Elsevier Science BV, Amsterdam., 1054, 297-306.
https://doi.org/10.1016/j.molstruc.2013.10.006

Antonijević-Nikolić M, Antić-Stanković J, Tanasković S, Korabik MJ, Gojgić-Cvijović G, Vucković G. Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes. in Journal of Molecular Structure. 2013;1054:297-306.
doi:10.1016/j.molstruc.2013.10.006 .

Antonijević-Nikolić, Mirjana, Antić-Stanković, Jelena, Tanasković, Slađana, Korabik, Maria J., Gojgić-Cvijović, Gordana, Vucković, Gordana, "Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes" in Journal of Molecular Structure, 1054 (2013):297-306,
https://doi.org/10.1016/j.molstruc.2013.10.006 . .