TY  - CONF
AU  - Umićević, Nina
AU  - Kotur-Stevuljević, Jelena
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5430
AB  - Zaposleni u industriji obuće su potencijalno izloženi smješi organskih rastvarača, što predstavlja povećan rizik od hepatotoksičnosti, neurotoksičnosti i hematotoksičnosti. Toksičnost smješe se često može previdjeti, a još uvek nema dovoljno podataka o mehanizmima koji se aktiviraju u ljudskom organizmu uslijed profesionalne izloženosti niskim koncentracijama rastvarača. ...
AB  - Employees in the shoe industry are potentially exposed to a mixture of organic solvents, which poses an increased risk of hepatotoxicity, neurotoxicity and hematotoxicity. The toxicity of the mixture can often be overlooked, and there are still uncertainties in occupational exposure to low concentrations of solvents regarding the mechanisms triggered in the human body. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Parametri oksidativog stresa kod radnika izloženih smješi niskih koncentracija organskih rastvarača
T1  - Oxidative stress parameters in workers exposed to a mixture of low-level organic solvents
SP  - 69
EP  - 70
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5430
ER  - 

@conference{
author = "Umićević, Nina and Kotur-Stevuljević, Jelena and Baralić, Katarina and Đukić-Ćosić, Danijela and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "Zaposleni u industriji obuće su potencijalno izloženi smješi organskih rastvarača, što predstavlja povećan rizik od hepatotoksičnosti, neurotoksičnosti i hematotoksičnosti. Toksičnost smješe se često može previdjeti, a još uvek nema dovoljno podataka o mehanizmima koji se aktiviraju u ljudskom organizmu uslijed profesionalne izloženosti niskim koncentracijama rastvarača. ..., Employees in the shoe industry are potentially exposed to a mixture of organic solvents, which poses an increased risk of hepatotoxicity, neurotoxicity and hematotoxicity. The toxicity of the mixture can often be overlooked, and there are still uncertainties in occupational exposure to low concentrations of solvents regarding the mechanisms triggered in the human body. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Parametri oksidativog stresa kod radnika izloženih smješi niskih koncentracija organskih rastvarača, Oxidative stress parameters in workers exposed to a mixture of low-level organic solvents",
pages = "69-70",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5430"
}

Umićević, N., Kotur-Stevuljević, J., Baralić, K., Đukić-Ćosić, D., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z.,& Antonijević, B.. (2023). Parametri oksidativog stresa kod radnika izloženih smješi niskih koncentracija organskih rastvarača. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 69-70.
https://hdl.handle.net/21.15107/rcub_farfar_5430

Umićević N, Kotur-Stevuljević J, Baralić K, Đukić-Ćosić D, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B. Parametri oksidativog stresa kod radnika izloženih smješi niskih koncentracija organskih rastvarača. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:69-70.
https://hdl.handle.net/21.15107/rcub_farfar_5430 .

Umićević, Nina, Kotur-Stevuljević, Jelena, Baralić, Katarina, Đukić-Ćosić, Danijela, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, "Parametri oksidativog stresa kod radnika izloženih smješi niskih koncentracija organskih rastvarača" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):69-70,
https://hdl.handle.net/21.15107/rcub_farfar_5430 .

TY  - CONF
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5514
AB  - Poslednje dve decenije intenzivno se razvija toksikogenomika sa ciljem da prikupi, objedini i analizira podatke o uticaju toksičnih supstanci na nivou gena i da ih integriše u baze podataka, poput Komparativne toksikogenomske baze podataka (engl. Comparative Toxicogenomic Database, CTD; http:// ctdbase.org/). ...
AB  - In the last two decades, toxicogenomics has been intensively developed with the aim of collecting, standardizing, and analyzing data on toxic substances that affect genes and integrating them into databases, such as the Comparative Toxicogenomic Database (CTD; http://ctdbase.org/). ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Komparativna toksikogenomska baza podataka: Nove mogućnosti
T1  - The Comparative Toxicogenomic Database: New possibilities
SP  - 157
EP  - 158
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5514
ER  - 

@conference{
author = "Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Vukelić, Dragana and Marić, Đurđica and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Poslednje dve decenije intenzivno se razvija toksikogenomika sa ciljem da prikupi, objedini i analizira podatke o uticaju toksičnih supstanci na nivou gena i da ih integriše u baze podataka, poput Komparativne toksikogenomske baze podataka (engl. Comparative Toxicogenomic Database, CTD; http:// ctdbase.org/). ..., In the last two decades, toxicogenomics has been intensively developed with the aim of collecting, standardizing, and analyzing data on toxic substances that affect genes and integrating them into databases, such as the Comparative Toxicogenomic Database (CTD; http://ctdbase.org/). ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Komparativna toksikogenomska baza podataka: Nove mogućnosti, The Comparative Toxicogenomic Database: New possibilities",
pages = "157-158",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5514"
}

Živanović, J., Baralić, K., Božić, D., Živančević, K., Vukelić, D., Marić, Đ., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Komparativna toksikogenomska baza podataka: Nove mogućnosti. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 157-158.
https://hdl.handle.net/21.15107/rcub_farfar_5514

Živanović J, Baralić K, Božić D, Živančević K, Vukelić D, Marić Đ, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Komparativna toksikogenomska baza podataka: Nove mogućnosti. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:157-158.
https://hdl.handle.net/21.15107/rcub_farfar_5514 .

Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Vukelić, Dragana, Marić, Đurđica, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Komparativna toksikogenomska baza podataka: Nove mogućnosti" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):157-158,
https://hdl.handle.net/21.15107/rcub_farfar_5514 .

TY  - CONF
AU  - Vukelić, Dragana
AU  - Petrović, Bojana
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5486
AB  - Zagađenje vazduha predstavlja ekološki faktor rizika koji je povezan sa 1% svih slučajeva razvoja karcinoma i 2% svih smrtnih slučajeva usled razvoja karcinoma u Evropi. Postoji veliki broj podataka koji ukazuju na vezu između zagađenja vazduha, posebno suspendovanih čestica (PM), i pojave karcinoma pluća. ...
AB  - Air pollution represents environmental risk factor linked to 1% of all cancer incidences and 2% of all cancer deaths in Europe. There is a strong body of data linking outdoor (ambient) air pollution, particularly particulate matter (PM), with lung cancer incidence.  ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?
T1  - Exposure to outdoor air pollution and cancer development: Is air pollution responsible for more than lung cancer?
SP  - 59
EP  - 60
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5486
ER  - 

@conference{
author = "Vukelić, Dragana and Petrović, Bojana and Marić, Đurđica and Baralić, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "Zagađenje vazduha predstavlja ekološki faktor rizika koji je povezan sa 1% svih slučajeva razvoja karcinoma i 2% svih smrtnih slučajeva usled razvoja karcinoma u Evropi. Postoji veliki broj podataka koji ukazuju na vezu između zagađenja vazduha, posebno suspendovanih čestica (PM), i pojave karcinoma pluća. ..., Air pollution represents environmental risk factor linked to 1% of all cancer incidences and 2% of all cancer deaths in Europe. There is a strong body of data linking outdoor (ambient) air pollution, particularly particulate matter (PM), with lung cancer incidence.  ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?, Exposure to outdoor air pollution and cancer development: Is air pollution responsible for more than lung cancer?",
pages = "59-60",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5486"
}

Vukelić, D., Petrović, B., Marić, Đ., Baralić, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Đukić-Ćosić, D., Ćurčić, M., Antonijević, B.,& Bulat, Z.. (2023). Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 59-60.
https://hdl.handle.net/21.15107/rcub_farfar_5486

Vukelić D, Petrović B, Marić Đ, Baralić K, Antonijević-Miljaković E, Buha-Đorđević A, Đukić-Ćosić D, Ćurčić M, Antonijević B, Bulat Z. Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:59-60.
https://hdl.handle.net/21.15107/rcub_farfar_5486 .

Vukelić, Dragana, Petrović, Bojana, Marić, Đurđica, Baralić, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Antonijević, Biljana, Bulat, Zorica, "Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):59-60,
https://hdl.handle.net/21.15107/rcub_farfar_5486 .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Blagojević, Zorica
AU  - Milenković, Milan
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Đorđević, Snežana
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5438
AB  - Materijali i predmeti u kontaktu sa hranom mogu da sadrže bisfenol A koji se dodaje kao plastifikator
ili antioksidans pri izradi plastike ali je i sastavni deo epoksi smola koje se koriste kao unutrašnji
premazi za konzerve u kojima se čuvaju namirnice. ...
AB  - Food contact materials can contain bisphenol A added as a plasticizer or antioxidant as well as a component of epoxy resins that are a coating material for food cans. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Validacija metode tečne hromatografije sa fluorescentim detektorom (HPLC-FLD) za određivanja bisfenola a u materijalima i predmetima koji dolaze u kontakt sa hranom
T1  - Validation of the high-performance liquid chromatography with fluorescence detection method (HPLC-FLD) for the determination of bisphenol a in food contact material
SP  - 13
EP  - 14
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5438
ER  - 

@conference{
author = "Ćurčić, Marijana and Blagojević, Zorica and Milenković, Milan and Baralić, Katarina and Vukelić, Dragana and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Đorđević, Snežana and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "Materijali i predmeti u kontaktu sa hranom mogu da sadrže bisfenol A koji se dodaje kao plastifikator
ili antioksidans pri izradi plastike ali je i sastavni deo epoksi smola koje se koriste kao unutrašnji
premazi za konzerve u kojima se čuvaju namirnice. ..., Food contact materials can contain bisphenol A added as a plasticizer or antioxidant as well as a component of epoxy resins that are a coating material for food cans. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Validacija metode tečne hromatografije sa fluorescentim detektorom (HPLC-FLD) za određivanja bisfenola a u materijalima i predmetima koji dolaze u kontakt sa hranom, Validation of the high-performance liquid chromatography with fluorescence detection method (HPLC-FLD) for the determination of bisphenol a in food contact material",
pages = "13-14",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5438"
}

Ćurčić, M., Blagojević, Z., Milenković, M., Baralić, K., Vukelić, D., Antonijević-Miljaković, E., Đukić-Ćosić, D., Đorđević, S., Antonijević, B.,& Bulat, Z.. (2023). Validacija metode tečne hromatografije sa fluorescentim detektorom (HPLC-FLD) za određivanja bisfenola a u materijalima i predmetima koji dolaze u kontakt sa hranom. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 13-14.
https://hdl.handle.net/21.15107/rcub_farfar_5438

Ćurčić M, Blagojević Z, Milenković M, Baralić K, Vukelić D, Antonijević-Miljaković E, Đukić-Ćosić D, Đorđević S, Antonijević B, Bulat Z. Validacija metode tečne hromatografije sa fluorescentim detektorom (HPLC-FLD) za određivanja bisfenola a u materijalima i predmetima koji dolaze u kontakt sa hranom. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:13-14.
https://hdl.handle.net/21.15107/rcub_farfar_5438 .

Ćurčić, Marijana, Blagojević, Zorica, Milenković, Milan, Baralić, Katarina, Vukelić, Dragana, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Đorđević, Snežana, Antonijević, Biljana, Bulat, Zorica, "Validacija metode tečne hromatografije sa fluorescentim detektorom (HPLC-FLD) za određivanja bisfenola a u materijalima i predmetima koji dolaze u kontakt sa hranom" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):13-14,
https://hdl.handle.net/21.15107/rcub_farfar_5438 .

TY  - CONF
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Zhang, Yi
AU  - Yang, Li
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5425
AB  - Sulforafan (SFN) je imunomodulator poreklom iz kupusastog povrća čija su antioksidativna i antikancerogena svojstva prepoznata sredinom prošlog veka. Međutim, njegov toksikološki profil i potencijal da izazove štetne efekte su nedovoljno razjašnjeni. Cilj ove studije bio je predviđanje toksičnog potencijala SFN kombinovanjem bioinformatičkih analiza. ...
AB  - Sulforaphane (SFN) is an immunomodulator from cruciferous vegetables whose anti-oxidative and anti-carcinogenic properties were recognized in the middle of the last century. However, its toxicological profile remains insufficiently elucidated. The aim of the study was to predict the toxicity of SFN by combining bioinformatic analyses. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza
T1  - Predicting toxic effects of an immunomodulator, sulforaphane: Bioinformatic analsis
SP  - 61
EP  - 62
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5425
ER  - 

@conference{
author = "Božić, Dragica and Baralić, Katarina and Živančević, Katarina and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Zhang, Yi and Yang, Li and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Sulforafan (SFN) je imunomodulator poreklom iz kupusastog povrća čija su antioksidativna i antikancerogena svojstva prepoznata sredinom prošlog veka. Međutim, njegov toksikološki profil i potencijal da izazove štetne efekte su nedovoljno razjašnjeni. Cilj ove studije bio je predviđanje toksičnog potencijala SFN kombinovanjem bioinformatičkih analiza. ..., Sulforaphane (SFN) is an immunomodulator from cruciferous vegetables whose anti-oxidative and anti-carcinogenic properties were recognized in the middle of the last century. However, its toxicological profile remains insufficiently elucidated. The aim of the study was to predict the toxicity of SFN by combining bioinformatic analyses. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza, Predicting toxic effects of an immunomodulator, sulforaphane: Bioinformatic analsis",
pages = "61-62",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5425"
}

Božić, D., Baralić, K., Živančević, K., Buha-Đorđević, A., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B., Zhang, Y., Yang, L.,& Đukić-Ćosić, D.. (2023). Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 61-62.
https://hdl.handle.net/21.15107/rcub_farfar_5425

Božić D, Baralić K, Živančević K, Buha-Đorđević A, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Zhang Y, Yang L, Đukić-Ćosić D. Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:61-62.
https://hdl.handle.net/21.15107/rcub_farfar_5425 .

Božić, Dragica, Baralić, Katarina, Živančević, Katarina, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Zhang, Yi, Yang, Li, Đukić-Ćosić, Danijela, "Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):61-62,
https://hdl.handle.net/21.15107/rcub_farfar_5425 .

TY  - CONF
AU  - Baralić, Katarina
AU  - Pavić, Aleksandar
AU  - Javorac, Dragana
AU  - Živančević, Katarina
AU  - Božić, Dragica
AU  - Radaković, Nataša
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5422
AB  - Široka upotreba bis(2-etilheksil) ftalata (DEHP), dibutil ftalata (DBP) i bisfenola A (BPA) otvara niz mogućnosti
za kombinovanu izloženost ljudi ovim toksičnim jedinjenjima u svakodnevnom životu i brojne štetne
ishode, uključujući hepatotoksičnost.  ...
AB  - The extensive usage of bis(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A
(BPA) creates a lot of opportunities for combined human exposure to these hazardous compounds in
everyday life and a variety of negative outcomes, including hepatotoxicity. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Tri nivoa dokaza hepatotoksičnosti smeše ftalata i bisfenola a: In silico i dva in vivo modela
T1  - Three lines of evidence of the hepatotoxicity of a mixture containing phthalates and bisphenol a: In silico and two in vivo models
SP  - 55
EP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5422
ER  - 

@conference{
author = "Baralić, Katarina and Pavić, Aleksandar and Javorac, Dragana and Živančević, Katarina and Božić, Dragica and Radaković, Nataša and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Široka upotreba bis(2-etilheksil) ftalata (DEHP), dibutil ftalata (DBP) i bisfenola A (BPA) otvara niz mogućnosti
za kombinovanu izloženost ljudi ovim toksičnim jedinjenjima u svakodnevnom životu i brojne štetne
ishode, uključujući hepatotoksičnost.  ..., The extensive usage of bis(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A
(BPA) creates a lot of opportunities for combined human exposure to these hazardous compounds in
everyday life and a variety of negative outcomes, including hepatotoxicity. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Tri nivoa dokaza hepatotoksičnosti smeše ftalata i bisfenola a: In silico i dva in vivo modela, Three lines of evidence of the hepatotoxicity of a mixture containing phthalates and bisphenol a: In silico and two in vivo models",
pages = "55-56",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5422"
}

Baralić, K., Pavić, A., Javorac, D., Živančević, K., Božić, D., Radaković, N., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Tri nivoa dokaza hepatotoksičnosti smeše ftalata i bisfenola a: In silico i dva in vivo modela. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 55-56.
https://hdl.handle.net/21.15107/rcub_farfar_5422

Baralić K, Pavić A, Javorac D, Živančević K, Božić D, Radaković N, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Tri nivoa dokaza hepatotoksičnosti smeše ftalata i bisfenola a: In silico i dva in vivo modela. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:55-56.
https://hdl.handle.net/21.15107/rcub_farfar_5422 .

Baralić, Katarina, Pavić, Aleksandar, Javorac, Dragana, Živančević, Katarina, Božić, Dragica, Radaković, Nataša, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Tri nivoa dokaza hepatotoksičnosti smeše ftalata i bisfenola a: In silico i dva in vivo modela" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):55-56,
https://hdl.handle.net/21.15107/rcub_farfar_5422 .

TY  - CONF
AU  - Živanović, Jovana
AU  - Šljivić, Jovana
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Marić, Đurđica
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5171
AB  - Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...
PB  - Elsevier
C3  - Toxicology Letters
T1  - Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation
VL  - 384
IS  - S1
SP  - S114
EP  - S114
DO  - 10.1016/S0378-4274(23)00534-9
ER  - 

@conference{
author = "Živanović, Jovana and Šljivić, Jovana and Božić, Dragica and Baralić, Katarina and Živančević, Katarina and Marić, Đurđica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation",
volume = "384",
number = "S1",
pages = "S114-S114",
doi = "10.1016/S0378-4274(23)00534-9"
}

Živanović, J., Šljivić, J., Božić, D., Baralić, K., Živančević, K., Marić, Đ., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation. in Toxicology Letters
Elsevier., 384(S1), S114-S114.
https://doi.org/10.1016/S0378-4274(23)00534-9

Živanović J, Šljivić J, Božić D, Baralić K, Živančević K, Marić Đ, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation. in Toxicology Letters. 2023;384(S1):S114-S114.
doi:10.1016/S0378-4274(23)00534-9 .

Živanović, Jovana, Šljivić, Jovana, Božić, Dragica, Baralić, Katarina, Živančević, Katarina, Marić, Đurđica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation" in Toxicology Letters, 384, no. S1 (2023):S114-S114,
https://doi.org/10.1016/S0378-4274(23)00534-9 . .

TY  - JOUR
AU  - Radovanović, Jelena
AU  - Antonijević, Biljana
AU  - Kolarević, Stoimir
AU  - Milutinović-Smiljanić, Sanja
AU  - Mandić, Jelena
AU  - Vuković-Gačić, Branka
AU  - Bulat, Zorica
AU  - Ćurčić, Marijana
AU  - Kračun-Kolarević, Margareta
AU  - Sunjog, Karolina
AU  - Kostić-Vuković, Jovana
AU  - Jovanović Marić, Jovana
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Buha-Đorđević, Aleksandra
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Mandinić, Zoran
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3761
AB  - The aims of this study were to: (i) examine the toxic effects of sodium fluoride (NaF) in blood, liver, spleen, and brain cells of Wistar rats after the subacute exposure; (ii) explore the potential protective properties of selenium (Se) against fluoride toxicity after the simultaneous administration. Twenty male Wistar rats, eight weeks old, weighing approximately 140–190 g, were divided into four experimental groups (n = 5) as follows: I control-tap water; II NaF 150 ppm; III NaF 150 ppm and Se 1.5 mg/L; IV Se 1.5 mg/L, and had available water with solutions ad libitum for 28 days. DNA damage detected by comet assay was confirmed in the liver, spleen, and brain cells, but not in blood. Selenium supplementation together with NaF decreased DNA damage in liver and spleen cells. According to the histological findings, no changes were observed in spleen and brain tissues after NaF administration. Unlike the observed Se protective effect on the DNA level, no significant reduction of liver tissue injury was observed after the NaF and Se treatment, resulting in mild inflammation. Data of this study suggest that DNA damage after NaF subacute exposure at moderately high concentration was reduced in liver and spleen cells due to Se supplementation, but a similar change was not seen in the brain.
PB  - Elsevier Ltd
T2  - Chemosphere
T1  - Genotoxicity of fluoride subacute exposure in rats and selenium intervention
VL  - 266
DO  - 10.1016/j.chemosphere.2020.128978
ER  - 

@article{
author = "Radovanović, Jelena and Antonijević, Biljana and Kolarević, Stoimir and Milutinović-Smiljanić, Sanja and Mandić, Jelena and Vuković-Gačić, Branka and Bulat, Zorica and Ćurčić, Marijana and Kračun-Kolarević, Margareta and Sunjog, Karolina and Kostić-Vuković, Jovana and Jovanović Marić, Jovana and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Buha-Đorđević, Aleksandra and Javorac, Dragana and Baralić, Katarina and Mandinić, Zoran",
year = "2021",
abstract = "The aims of this study were to: (i) examine the toxic effects of sodium fluoride (NaF) in blood, liver, spleen, and brain cells of Wistar rats after the subacute exposure; (ii) explore the potential protective properties of selenium (Se) against fluoride toxicity after the simultaneous administration. Twenty male Wistar rats, eight weeks old, weighing approximately 140–190 g, were divided into four experimental groups (n = 5) as follows: I control-tap water; II NaF 150 ppm; III NaF 150 ppm and Se 1.5 mg/L; IV Se 1.5 mg/L, and had available water with solutions ad libitum for 28 days. DNA damage detected by comet assay was confirmed in the liver, spleen, and brain cells, but not in blood. Selenium supplementation together with NaF decreased DNA damage in liver and spleen cells. According to the histological findings, no changes were observed in spleen and brain tissues after NaF administration. Unlike the observed Se protective effect on the DNA level, no significant reduction of liver tissue injury was observed after the NaF and Se treatment, resulting in mild inflammation. Data of this study suggest that DNA damage after NaF subacute exposure at moderately high concentration was reduced in liver and spleen cells due to Se supplementation, but a similar change was not seen in the brain.",
publisher = "Elsevier Ltd",
journal = "Chemosphere",
title = "Genotoxicity of fluoride subacute exposure in rats and selenium intervention",
volume = "266",
doi = "10.1016/j.chemosphere.2020.128978"
}

Radovanović, J., Antonijević, B., Kolarević, S., Milutinović-Smiljanić, S., Mandić, J., Vuković-Gačić, B., Bulat, Z., Ćurčić, M., Kračun-Kolarević, M., Sunjog, K., Kostić-Vuković, J., Jovanović Marić, J., Antonijević-Miljaković, E., Đukić-Ćosić, D., Buha-Đorđević, A., Javorac, D., Baralić, K.,& Mandinić, Z.. (2021). Genotoxicity of fluoride subacute exposure in rats and selenium intervention. in Chemosphere
Elsevier Ltd., 266.
https://doi.org/10.1016/j.chemosphere.2020.128978

Radovanović J, Antonijević B, Kolarević S, Milutinović-Smiljanić S, Mandić J, Vuković-Gačić B, Bulat Z, Ćurčić M, Kračun-Kolarević M, Sunjog K, Kostić-Vuković J, Jovanović Marić J, Antonijević-Miljaković E, Đukić-Ćosić D, Buha-Đorđević A, Javorac D, Baralić K, Mandinić Z. Genotoxicity of fluoride subacute exposure in rats and selenium intervention. in Chemosphere. 2021;266.
doi:10.1016/j.chemosphere.2020.128978 .

Radovanović, Jelena, Antonijević, Biljana, Kolarević, Stoimir, Milutinović-Smiljanić, Sanja, Mandić, Jelena, Vuković-Gačić, Branka, Bulat, Zorica, Ćurčić, Marijana, Kračun-Kolarević, Margareta, Sunjog, Karolina, Kostić-Vuković, Jovana, Jovanović Marić, Jovana, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Buha-Đorđević, Aleksandra, Javorac, Dragana, Baralić, Katarina, Mandinić, Zoran, "Genotoxicity of fluoride subacute exposure in rats and selenium intervention" in Chemosphere, 266 (2021),
https://doi.org/10.1016/j.chemosphere.2020.128978 . .

TY  - JOUR
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Javorac, Dragana
AU  - Čolaković, Nataša
AU  - Oprić, Svetlana
AU  - Petričević, Simona
AU  - Granić, Miroslav
AU  - Kotur-Stevuljević, Jelena
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3915
AB  - Breast cancer is at the forefront of female malignancy and the leading cause of cancer death among women. Gender, age, hormone therapy, smoking, exposure to endocrine disruptors and family history are significant breast cancer risk factors according to epidemiological data. Considering metalloestrogenic Cd property and a plethora of research work on hormone involvement in breast cancer the study aimed to determine Cd concentration in three compartments of breast cancer patients in relation to their blood hormone status. Further, as oxidative stress is a critical mechanism of Cd toxicity, the objective of this study was to determine potential changes in oxidative status homeostasis. The study enrolled 55 patients with breast cancer diagnosis and 41 healthy women with benign breast changes. Concentration of Cd was determined using graphite furnace atomic absorption spectrometry. Cadmium concentration in tumor tissue was significantly higher than control and almost four times higher than Cd concentration in the healthy surrounding tissue. Strong positive correlation was observed between Cd concentrations in changed breast tissue and FSH and LH levels, while the correlation was negative with estradiol level. Cancer patients had significantly increased blood total antioxidative status while total oxidative status did not significantly differ between study groups. The study revealed Cd implication in breast cancer onset following a significant odd ratio for Cd levels in changed tissue samples. Moreover, presented data confirmed sex hormone and oxidative status imbalance caused by Cd presence, closely related to cancer development.
PB  - Elsevier
T2  - Environmental Research
T1  - Cadmium tissue level in women diagnosed with breast cancer – A case control study
VL  - 199
DO  - 10.1016/j.envres.2021.111300
ER  - 

@article{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Javorac, Dragana and Čolaković, Nataša and Oprić, Svetlana and Petričević, Simona and Granić, Miroslav and Kotur-Stevuljević, Jelena and Antonijević, Biljana and Bulat, Zorica",
year = "2021",
abstract = "Breast cancer is at the forefront of female malignancy and the leading cause of cancer death among women. Gender, age, hormone therapy, smoking, exposure to endocrine disruptors and family history are significant breast cancer risk factors according to epidemiological data. Considering metalloestrogenic Cd property and a plethora of research work on hormone involvement in breast cancer the study aimed to determine Cd concentration in three compartments of breast cancer patients in relation to their blood hormone status. Further, as oxidative stress is a critical mechanism of Cd toxicity, the objective of this study was to determine potential changes in oxidative status homeostasis. The study enrolled 55 patients with breast cancer diagnosis and 41 healthy women with benign breast changes. Concentration of Cd was determined using graphite furnace atomic absorption spectrometry. Cadmium concentration in tumor tissue was significantly higher than control and almost four times higher than Cd concentration in the healthy surrounding tissue. Strong positive correlation was observed between Cd concentrations in changed breast tissue and FSH and LH levels, while the correlation was negative with estradiol level. Cancer patients had significantly increased blood total antioxidative status while total oxidative status did not significantly differ between study groups. The study revealed Cd implication in breast cancer onset following a significant odd ratio for Cd levels in changed tissue samples. Moreover, presented data confirmed sex hormone and oxidative status imbalance caused by Cd presence, closely related to cancer development.",
publisher = "Elsevier",
journal = "Environmental Research",
title = "Cadmium tissue level in women diagnosed with breast cancer – A case control study",
volume = "199",
doi = "10.1016/j.envres.2021.111300"
}

Anđelković, M., Buha-Đorđević, A., Antonijević-Miljaković, E., Javorac, D., Čolaković, N., Oprić, S., Petričević, S., Granić, M., Kotur-Stevuljević, J., Antonijević, B.,& Bulat, Z.. (2021). Cadmium tissue level in women diagnosed with breast cancer – A case control study. in Environmental Research
Elsevier., 199.
https://doi.org/10.1016/j.envres.2021.111300

Anđelković M, Buha-Đorđević A, Antonijević-Miljaković E, Javorac D, Čolaković N, Oprić S, Petričević S, Granić M, Kotur-Stevuljević J, Antonijević B, Bulat Z. Cadmium tissue level in women diagnosed with breast cancer – A case control study. in Environmental Research. 2021;199.
doi:10.1016/j.envres.2021.111300 .

Anđelković, Milena, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Javorac, Dragana, Čolaković, Nataša, Oprić, Svetlana, Petričević, Simona, Granić, Miroslav, Kotur-Stevuljević, Jelena, Antonijević, Biljana, Bulat, Zorica, "Cadmium tissue level in women diagnosed with breast cancer – A case control study" in Environmental Research, 199 (2021),
https://doi.org/10.1016/j.envres.2021.111300 . .

TY  - JOUR
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Jorgovanović, Dragica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3780
AB  - This in silico toxicogenomic analysis aims to: (i) testify the hypothesis about the influence of the environmentally
relevant toxic metals (lead, methylmercury (organic form of mercury), cadmium and arsenic) on molecular
mechanisms involved in amyotrophic lateral sclerosis (ALS), Parkinson’s Disease (PD) and Alzheimer’s disease
(AD) development; and (ii) demonstrate the capability of in silico toxicogenomic data-mining for distinguishing
the probable mechanisms of mixture-induced toxic effects. The Comparative Toxicogenomics Database (CTD;
http://ctd. mdibl.org) and Cytoscape software were used as the main data-mining tools in this analysis. The
results have shown that there were 7, 13 and 14 common genes for all the metals present in the mixture for each
of the selected neurodegenerative disease (ND), respectively: ALS, PD and AD. Physical interactions (68.18%)
were the most prominent interactions between the genes extracted for ALS, co-expression (60.85%) for PD and
interactions predicted by the server (44.30%) for AD. SOD2 gene was noted as the mutual gene for all the
selected ND. Oxidative stress, folate metabolism, vitamin B12, AGE-RAGE, apoptosis were noted as the key
disrupted molecular pathways that contribute to the neurodegenerative disease’s development. Gene ontology
analysis revealed biological processes affected by the investigated mixture (glutathione metabolic process was
listed as the most important for ALS, cellular response to toxic substance for PD, and neuron death for AD). Our
results emphasize the role of oxidative stress, particularly SOD2, in neurodegeneration triggered by environmental toxic metal mixture and give a new insight into common molecular mechanisms involved in ALS, PD and
AD pathology.
PB  - Elsevier
T2  - Environmental Research
T1  - Elucidating the influence of environmentally relevant toxic metal mixture on molecular mechanisms involved in the development of neurodegenerative diseases: In silico toxicogenomic data-mining
VL  - 194
DO  - 10.1016/j.envres.2021.110727
ER  - 

@article{
author = "Živančević, Katarina and Baralić, Katarina and Jorgovanović, Dragica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Antonijević, Biljana and Bulat, Zorica",
year = "2021",
abstract = "This in silico toxicogenomic analysis aims to: (i) testify the hypothesis about the influence of the environmentally
relevant toxic metals (lead, methylmercury (organic form of mercury), cadmium and arsenic) on molecular
mechanisms involved in amyotrophic lateral sclerosis (ALS), Parkinson’s Disease (PD) and Alzheimer’s disease
(AD) development; and (ii) demonstrate the capability of in silico toxicogenomic data-mining for distinguishing
the probable mechanisms of mixture-induced toxic effects. The Comparative Toxicogenomics Database (CTD;
http://ctd. mdibl.org) and Cytoscape software were used as the main data-mining tools in this analysis. The
results have shown that there were 7, 13 and 14 common genes for all the metals present in the mixture for each
of the selected neurodegenerative disease (ND), respectively: ALS, PD and AD. Physical interactions (68.18%)
were the most prominent interactions between the genes extracted for ALS, co-expression (60.85%) for PD and
interactions predicted by the server (44.30%) for AD. SOD2 gene was noted as the mutual gene for all the
selected ND. Oxidative stress, folate metabolism, vitamin B12, AGE-RAGE, apoptosis were noted as the key
disrupted molecular pathways that contribute to the neurodegenerative disease’s development. Gene ontology
analysis revealed biological processes affected by the investigated mixture (glutathione metabolic process was
listed as the most important for ALS, cellular response to toxic substance for PD, and neuron death for AD). Our
results emphasize the role of oxidative stress, particularly SOD2, in neurodegeneration triggered by environmental toxic metal mixture and give a new insight into common molecular mechanisms involved in ALS, PD and
AD pathology.",
publisher = "Elsevier",
journal = "Environmental Research",
title = "Elucidating the influence of environmentally relevant toxic metal mixture on molecular mechanisms involved in the development of neurodegenerative diseases: In silico toxicogenomic data-mining",
volume = "194",
doi = "10.1016/j.envres.2021.110727"
}

Živančević, K., Baralić, K., Jorgovanović, D., Buha-Đorđević, A., Ćurčić, M., Antonijević-Miljaković, E., Antonijević, B.,& Bulat, Z.. (2021). Elucidating the influence of environmentally relevant toxic metal mixture on molecular mechanisms involved in the development of neurodegenerative diseases: In silico toxicogenomic data-mining. in Environmental Research
Elsevier., 194.
https://doi.org/10.1016/j.envres.2021.110727

Živančević K, Baralić K, Jorgovanović D, Buha-Đorđević A, Ćurčić M, Antonijević-Miljaković E, Antonijević B, Bulat Z. Elucidating the influence of environmentally relevant toxic metal mixture on molecular mechanisms involved in the development of neurodegenerative diseases: In silico toxicogenomic data-mining. in Environmental Research. 2021;194.
doi:10.1016/j.envres.2021.110727 .

Živančević, Katarina, Baralić, Katarina, Jorgovanović, Dragica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Antonijević, Biljana, Bulat, Zorica, "Elucidating the influence of environmentally relevant toxic metal mixture on molecular mechanisms involved in the development of neurodegenerative diseases: In silico toxicogenomic data-mining" in Environmental Research, 194 (2021),
https://doi.org/10.1016/j.envres.2021.110727 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Jorgovanović, Dragica
AU  - Živančević, Katarina
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Miljković, Milica
AU  - Kotur-Stevuljević, Jelena
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3762
AB  - The aim of this study was to: (i) determine and compare the capacity of bis (2 –ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), bisphenol A (BPA), and their mixture to produce testicular toxicity after the subacute exposure; (ii) explore the mechanisms behind the observed changes using in silico toxicogenomic approach. Male rats were randomly split into groups (n = 6): (1) Control (corn oil); (2) DEHP (50 mg/kg b.w./day); (3) DBP (50 mg/kg b.w./day); (4) BPA (25 mg/kg b.w./day); and (5) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA). Animals were sacrificed after 28 days of oral exposure, testes were extracted and prepared for histological assessments under the light microscope (haematoxylin and eosin staining) and redox status analysis. The Comparative Toxicogenomics Database (CTD; http://CTD.mdibl.org), Cytoscape software (https://cytoscape.org) and ToppGene Suite (https://toppgene.cchmc.org) were used for data-mining. Present pathohistological study has demonstrated more pronounced testicular toxicity of the MIX group (desquamated germinal epithelium cells, enlarged cells with hyperchromatic nuclei, multinucleated cell forms and intracytoplasmic vacuoles) in comparison with the single substances, while effects on redox status parameters were either more prominent, or present only in the MIX group. In silico investigation revealed 20 genes linked to male reproductive disorders, affected by all three investigated substances. Effects on metabolism, AhR pathway, apoptosis and oxidative stress could be singled out as the most probable mechanisms involved in the subacute DEHP, DBP and BPA mixture testicular toxicity, while the effect on oxidative stress parameters was confirmed by in vivo experiment.
PB  - Elsevier Ltd
T2  - Chemosphere
T1  - Combining in vivo pathohistological and redox status analysis with in silico toxicogenomic study to explore the phthalates and bisphenol A mixture-induced testicular toxicity
VL  - 267
DO  - 10.1016/j.chemosphere.2020.129296
ER  - 

@article{
author = "Baralić, Katarina and Jorgovanović, Dragica and Živančević, Katarina and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Miljković, Milica and Kotur-Stevuljević, Jelena and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2021",
abstract = "The aim of this study was to: (i) determine and compare the capacity of bis (2 –ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), bisphenol A (BPA), and their mixture to produce testicular toxicity after the subacute exposure; (ii) explore the mechanisms behind the observed changes using in silico toxicogenomic approach. Male rats were randomly split into groups (n = 6): (1) Control (corn oil); (2) DEHP (50 mg/kg b.w./day); (3) DBP (50 mg/kg b.w./day); (4) BPA (25 mg/kg b.w./day); and (5) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA). Animals were sacrificed after 28 days of oral exposure, testes were extracted and prepared for histological assessments under the light microscope (haematoxylin and eosin staining) and redox status analysis. The Comparative Toxicogenomics Database (CTD; http://CTD.mdibl.org), Cytoscape software (https://cytoscape.org) and ToppGene Suite (https://toppgene.cchmc.org) were used for data-mining. Present pathohistological study has demonstrated more pronounced testicular toxicity of the MIX group (desquamated germinal epithelium cells, enlarged cells with hyperchromatic nuclei, multinucleated cell forms and intracytoplasmic vacuoles) in comparison with the single substances, while effects on redox status parameters were either more prominent, or present only in the MIX group. In silico investigation revealed 20 genes linked to male reproductive disorders, affected by all three investigated substances. Effects on metabolism, AhR pathway, apoptosis and oxidative stress could be singled out as the most probable mechanisms involved in the subacute DEHP, DBP and BPA mixture testicular toxicity, while the effect on oxidative stress parameters was confirmed by in vivo experiment.",
publisher = "Elsevier Ltd",
journal = "Chemosphere",
title = "Combining in vivo pathohistological and redox status analysis with in silico toxicogenomic study to explore the phthalates and bisphenol A mixture-induced testicular toxicity",
volume = "267",
doi = "10.1016/j.chemosphere.2020.129296"
}

Baralić, K., Jorgovanović, D., Živančević, K., Buha-Đorđević, A., Antonijević-Miljaković, E., Miljković, M., Kotur-Stevuljević, J., Antonijević, B.,& Đukić-Ćosić, D.. (2021). Combining in vivo pathohistological and redox status analysis with in silico toxicogenomic study to explore the phthalates and bisphenol A mixture-induced testicular toxicity. in Chemosphere
Elsevier Ltd., 267.
https://doi.org/10.1016/j.chemosphere.2020.129296

Baralić K, Jorgovanović D, Živančević K, Buha-Đorđević A, Antonijević-Miljaković E, Miljković M, Kotur-Stevuljević J, Antonijević B, Đukić-Ćosić D. Combining in vivo pathohistological and redox status analysis with in silico toxicogenomic study to explore the phthalates and bisphenol A mixture-induced testicular toxicity. in Chemosphere. 2021;267.
doi:10.1016/j.chemosphere.2020.129296 .

Baralić, Katarina, Jorgovanović, Dragica, Živančević, Katarina, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Miljković, Milica, Kotur-Stevuljević, Jelena, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Combining in vivo pathohistological and redox status analysis with in silico toxicogenomic study to explore the phthalates and bisphenol A mixture-induced testicular toxicity" in Chemosphere, 267 (2021),
https://doi.org/10.1016/j.chemosphere.2020.129296 . .

TY  - JOUR
AU  - Ćupić Miladinović, Dejana
AU  - Prevendar Crnić, Andreja
AU  - Peković, Sanja
AU  - Dacić, Sanja
AU  - Ivanović, Saša
AU  - Santibanez, Juan Francisco
AU  - Ćupić, Vitomir
AU  - Borozan, Nevena
AU  - Antonijević-Miljaković, Evica
AU  - Borozan, Sunčica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3810
AB  - Chlorpyrifos is a extensively used organophosphate pesticide (OP). In this study, we closely looked into neurotoxicity of CPF and effect of vitamin B1, by checking the levels of cholinesterases, determining the activity of parameters of oxidative stress, inflammation and also level of apoptotic regulator. The study was performed on a total of 80 male Japanese quails (Coturnix japonica), (two control and 6 experimental groups, n = 10). Three group of quails were given by gavage chlorpyrifos (CPF) for 7 consecutive days at doses of 1.50 mg/kg b.w., 3.00 mg/kg b.w., and 6.00 mg/kg b.w. Another three groups were treated with 10 mg/kg b.w. of vitamin B1 i.m. 30 min after CPF application (in above mentioned doses). Our study have proved that all doses of CPF significantly inhibited cholinesterases in brain, while vitamin B1 reactivated them. CPF has led to an increase in the concentration of malondialdehyde (MDA), and activity of catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST), while tiamin changed the activity of antioxidant enzymes: CAT, SOD, GST. CPF stimulated apoptosis by decreasing B-cell lymphoma (Bcl-2) in brain, while application of vitamin B1 caused an increase of this parameter. CPF amplified inflammatory effect by elevating levels of inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX-2). Thiamine proved its anti-inflammatory property by decreasing the expression of iNOS and interleukin-1(IL-1) and interleukin-6(IL-6). This study is highly pertinent because there is little defense currently available to humans and animals to prevent toxic effects of pesticides.
PB  - Elsevier Ireland Ltd
T2  - Chemico-Biological Interactions
T1  - Recovery of brain cholinesterases and effect on parameters of oxidative stres and apoptosis in quails (Coturnix japonica) after chlorpyrifos and vitamin B1 administration
VL  - 333
DO  - 10.1016/j.cbi.2020.109312
ER  - 

@article{
author = "Ćupić Miladinović, Dejana and Prevendar Crnić, Andreja and Peković, Sanja and Dacić, Sanja and Ivanović, Saša and Santibanez, Juan Francisco and Ćupić, Vitomir and Borozan, Nevena and Antonijević-Miljaković, Evica and Borozan, Sunčica",
year = "2021",
abstract = "Chlorpyrifos is a extensively used organophosphate pesticide (OP). In this study, we closely looked into neurotoxicity of CPF and effect of vitamin B1, by checking the levels of cholinesterases, determining the activity of parameters of oxidative stress, inflammation and also level of apoptotic regulator. The study was performed on a total of 80 male Japanese quails (Coturnix japonica), (two control and 6 experimental groups, n = 10). Three group of quails were given by gavage chlorpyrifos (CPF) for 7 consecutive days at doses of 1.50 mg/kg b.w., 3.00 mg/kg b.w., and 6.00 mg/kg b.w. Another three groups were treated with 10 mg/kg b.w. of vitamin B1 i.m. 30 min after CPF application (in above mentioned doses). Our study have proved that all doses of CPF significantly inhibited cholinesterases in brain, while vitamin B1 reactivated them. CPF has led to an increase in the concentration of malondialdehyde (MDA), and activity of catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST), while tiamin changed the activity of antioxidant enzymes: CAT, SOD, GST. CPF stimulated apoptosis by decreasing B-cell lymphoma (Bcl-2) in brain, while application of vitamin B1 caused an increase of this parameter. CPF amplified inflammatory effect by elevating levels of inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX-2). Thiamine proved its anti-inflammatory property by decreasing the expression of iNOS and interleukin-1(IL-1) and interleukin-6(IL-6). This study is highly pertinent because there is little defense currently available to humans and animals to prevent toxic effects of pesticides.",
publisher = "Elsevier Ireland Ltd",
journal = "Chemico-Biological Interactions",
title = "Recovery of brain cholinesterases and effect on parameters of oxidative stres and apoptosis in quails (Coturnix japonica) after chlorpyrifos and vitamin B1 administration",
volume = "333",
doi = "10.1016/j.cbi.2020.109312"
}

Ćupić Miladinović, D., Prevendar Crnić, A., Peković, S., Dacić, S., Ivanović, S., Santibanez, J. F., Ćupić, V., Borozan, N., Antonijević-Miljaković, E.,& Borozan, S.. (2021). Recovery of brain cholinesterases and effect on parameters of oxidative stres and apoptosis in quails (Coturnix japonica) after chlorpyrifos and vitamin B1 administration. in Chemico-Biological Interactions
Elsevier Ireland Ltd., 333.
https://doi.org/10.1016/j.cbi.2020.109312

Ćupić Miladinović D, Prevendar Crnić A, Peković S, Dacić S, Ivanović S, Santibanez JF, Ćupić V, Borozan N, Antonijević-Miljaković E, Borozan S. Recovery of brain cholinesterases and effect on parameters of oxidative stres and apoptosis in quails (Coturnix japonica) after chlorpyrifos and vitamin B1 administration. in Chemico-Biological Interactions. 2021;333.
doi:10.1016/j.cbi.2020.109312 .

Ćupić Miladinović, Dejana, Prevendar Crnić, Andreja, Peković, Sanja, Dacić, Sanja, Ivanović, Saša, Santibanez, Juan Francisco, Ćupić, Vitomir, Borozan, Nevena, Antonijević-Miljaković, Evica, Borozan, Sunčica, "Recovery of brain cholinesterases and effect on parameters of oxidative stres and apoptosis in quails (Coturnix japonica) after chlorpyrifos and vitamin B1 administration" in Chemico-Biological Interactions, 333 (2021),
https://doi.org/10.1016/j.cbi.2020.109312 . .

TY  - JOUR
AU  - Javorac, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Anđelković, Milena
AU  - Tatović, Simona
AU  - Baralić, Katarina
AU  - Antonijević, Evica
AU  - Kotur-Stevuljević, Jelena
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3715
AB  - Most Pb and Cd neurotoxicity studies investigate exposure to either of the toxic metals alone, while data on co-exposure are scarce. The aim of our study was to fill that gap by investigating acute combined effects of Pb and Cd on redox and essential metal status in the brain of Wistar rats. Animals were randomised in four groups of six to eight rats, which received 15 or 30 mg/kg of Cd, 150 mg/kg of Pb, or 150 mg/kg of Pb + 15 mg/kg of Cd by gavage. The fifth, control, group received distilled water only. Co-treatment with Pb and Cd induced significant increase in malondialdehyde (MDA) and thiobarbituric acid-reactive substances (TBARS) compared to control and groups receiving either metal alone. This is of special importance, as MDA presence in the brain has been implicated in many neurodegenerative disorders. The groups did not significantly differ in Zn, Cu, Mn, and Fe brain levels. Our findings highlight the importance of metal mixture studies. Neurotoxicity assessments of single chemicals do not provide a real insight into exposure to mixtures in real life. Further research should look into interactions between these metals to reveal complex molecular mechanisms of their neurotoxicity.
AB  - Dosadašnji podatci o neurotoksičnosti olova (Pb) i kadmija (Cd) uglavnom su opisani nakon izloženosti pojedinačnim
metalima, a podatci o neurotoksičnom djelovanju smjese tih dvaju metala prilično su oskudni. Cilj ovoga rada bio je
ispitati učinak akutnoga izlaganja smjesi olova i kadmija na parametre oksidacijskoga stresa i status bioelemenata u mozgu
štakora. Životinje su bile podijeljene u pet skupina: Cd15 (15 mg/kg), Cd30 (30 mg/kg), Pb150 (150 mg/kg), Pb150+Cd15
i kontrolna, netretirana skupina. Smjesa olova i kadmija dovela je do značajno viših vrijednosti malondialdehida (MDA)
i drugih produkata u mozgu štakora u usporedbi s kontrolnom skupinom i obama pojedinačnim metalima. To je iznimno
važno, imajući u vidu da je prisutnost MDA-a u mozgu povezana s mnogim neurodegenerativnim poremećajima. Nije
dobivena statistički značajna razlika između ispitivanih skupina u razinama cinka (Zn), bakra (Cu), mangana (Mn) i
željeza (Fe). Rezultati ovoga istraživanja važan su doprinos budućim istraživanjima smjesa i upućuju na to da istraživanja
toksičnosti u kojima se procjenjuje neurotoksičnost pojedinačnih kemikalija ne pružaju stvarni uvid u neurotoksičnost
njihovih smjesa kojima smo izloženi u stvarnom životu. Dobiveni rezultati otvaraju daljnja pitanja o interakciji i
mehanizmima toksičnosti smjese tih metala.
PB  - Sciendo
T2  - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture
T1  - Redoks status i razine bioelemenata u mozgu štakora akutno izloženih smjesi kadmija i olova
VL  - 71
IS  - 3
SP  - 197
EP  - 204
DO  - 10.2478/aiht-2020-71-3425
ER  - 

@article{
author = "Javorac, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Tatović, Simona and Baralić, Katarina and Antonijević, Evica and Kotur-Stevuljević, Jelena and Đukić-Ćosić, Danijela and Antonijević, Biljana and Bulat, Zorica",
year = "2020",
abstract = "Most Pb and Cd neurotoxicity studies investigate exposure to either of the toxic metals alone, while data on co-exposure are scarce. The aim of our study was to fill that gap by investigating acute combined effects of Pb and Cd on redox and essential metal status in the brain of Wistar rats. Animals were randomised in four groups of six to eight rats, which received 15 or 30 mg/kg of Cd, 150 mg/kg of Pb, or 150 mg/kg of Pb + 15 mg/kg of Cd by gavage. The fifth, control, group received distilled water only. Co-treatment with Pb and Cd induced significant increase in malondialdehyde (MDA) and thiobarbituric acid-reactive substances (TBARS) compared to control and groups receiving either metal alone. This is of special importance, as MDA presence in the brain has been implicated in many neurodegenerative disorders. The groups did not significantly differ in Zn, Cu, Mn, and Fe brain levels. Our findings highlight the importance of metal mixture studies. Neurotoxicity assessments of single chemicals do not provide a real insight into exposure to mixtures in real life. Further research should look into interactions between these metals to reveal complex molecular mechanisms of their neurotoxicity., Dosadašnji podatci o neurotoksičnosti olova (Pb) i kadmija (Cd) uglavnom su opisani nakon izloženosti pojedinačnim
metalima, a podatci o neurotoksičnom djelovanju smjese tih dvaju metala prilično su oskudni. Cilj ovoga rada bio je
ispitati učinak akutnoga izlaganja smjesi olova i kadmija na parametre oksidacijskoga stresa i status bioelemenata u mozgu
štakora. Životinje su bile podijeljene u pet skupina: Cd15 (15 mg/kg), Cd30 (30 mg/kg), Pb150 (150 mg/kg), Pb150+Cd15
i kontrolna, netretirana skupina. Smjesa olova i kadmija dovela je do značajno viših vrijednosti malondialdehida (MDA)
i drugih produkata u mozgu štakora u usporedbi s kontrolnom skupinom i obama pojedinačnim metalima. To je iznimno
važno, imajući u vidu da je prisutnost MDA-a u mozgu povezana s mnogim neurodegenerativnim poremećajima. Nije
dobivena statistički značajna razlika između ispitivanih skupina u razinama cinka (Zn), bakra (Cu), mangana (Mn) i
željeza (Fe). Rezultati ovoga istraživanja važan su doprinos budućim istraživanjima smjesa i upućuju na to da istraživanja
toksičnosti u kojima se procjenjuje neurotoksičnost pojedinačnih kemikalija ne pružaju stvarni uvid u neurotoksičnost
njihovih smjesa kojima smo izloženi u stvarnom životu. Dobiveni rezultati otvaraju daljnja pitanja o interakciji i
mehanizmima toksičnosti smjese tih metala.",
publisher = "Sciendo",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture, Redoks status i razine bioelemenata u mozgu štakora akutno izloženih smjesi kadmija i olova",
volume = "71",
number = "3",
pages = "197-204",
doi = "10.2478/aiht-2020-71-3425"
}

Javorac, D., Buha-Đorđević, A., Anđelković, M., Tatović, S., Baralić, K., Antonijević, E., Kotur-Stevuljević, J., Đukić-Ćosić, D., Antonijević, B.,& Bulat, Z.. (2020). Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Sciendo., 71(3), 197-204.
https://doi.org/10.2478/aiht-2020-71-3425

Javorac D, Buha-Đorđević A, Anđelković M, Tatović S, Baralić K, Antonijević E, Kotur-Stevuljević J, Đukić-Ćosić D, Antonijević B, Bulat Z. Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2020;71(3):197-204.
doi:10.2478/aiht-2020-71-3425 .

Javorac, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Tatović, Simona, Baralić, Katarina, Antonijević, Evica, Kotur-Stevuljević, Jelena, Đukić-Ćosić, Danijela, Antonijević, Biljana, Bulat, Zorica, "Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 71, no. 3 (2020):197-204,
https://doi.org/10.2478/aiht-2020-71-3425 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Javorac, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Anđelković, Milena
AU  - Jorgovanović, Dragica
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3634
AB  - Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects. Literature data suggest that probiotic cultures might be able to decrease the adverse effects of toxic substances by various mechanisms. The aim of this study was to investigate if treatment with multi-strained probiotic could reduce the toxicity of phthalates and bisphenol A mixture in Wistar rats. Animals were divided into four experimental groups (n = 6): (1) Control (corn oil); (2) P (probiotic (8.78 * 108 CFU/kg/day): Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus planarum LP 6595+ Lactobacillus planarum HEAL9); (3) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA); (4) MIX + P. Animals were euthanized after 28 days of daily oral gavage treatment; blood and organs were collected for further analysis. Probiotic reduced systemic inflammation and had protective effects on liver, kidneys, spleen, lipid status and serum glucose level. It almost completely annulled the changes in biochemical, hematological and hormonal parameters and mitigated changes in relative liver size, food consumption and organ histology. These results suggest considering multi-strained probiotics as a dietary therapeutic strategy against toxicity of the investigated mixture.
PB  - Elsevier Ltd
T2  - Food and Chemical Toxicology
T1  - Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats
VL  - 143
DO  - 10.1016/j.fct.2020.111540
ER  - 

@article{
author = "Baralić, Katarina and Živančević, Katarina and Javorac, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Jorgovanović, Dragica and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2020",
abstract = "Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects. Literature data suggest that probiotic cultures might be able to decrease the adverse effects of toxic substances by various mechanisms. The aim of this study was to investigate if treatment with multi-strained probiotic could reduce the toxicity of phthalates and bisphenol A mixture in Wistar rats. Animals were divided into four experimental groups (n = 6): (1) Control (corn oil); (2) P (probiotic (8.78 * 108 CFU/kg/day): Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus planarum LP 6595+ Lactobacillus planarum HEAL9); (3) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA); (4) MIX + P. Animals were euthanized after 28 days of daily oral gavage treatment; blood and organs were collected for further analysis. Probiotic reduced systemic inflammation and had protective effects on liver, kidneys, spleen, lipid status and serum glucose level. It almost completely annulled the changes in biochemical, hematological and hormonal parameters and mitigated changes in relative liver size, food consumption and organ histology. These results suggest considering multi-strained probiotics as a dietary therapeutic strategy against toxicity of the investigated mixture.",
publisher = "Elsevier Ltd",
journal = "Food and Chemical Toxicology",
title = "Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats",
volume = "143",
doi = "10.1016/j.fct.2020.111540"
}

Baralić, K., Živančević, K., Javorac, D., Buha-Đorđević, A., Anđelković, M., Jorgovanović, D., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2020). Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats. in Food and Chemical Toxicology
Elsevier Ltd., 143.
https://doi.org/10.1016/j.fct.2020.111540

Baralić K, Živančević K, Javorac D, Buha-Đorđević A, Anđelković M, Jorgovanović D, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats. in Food and Chemical Toxicology. 2020;143.
doi:10.1016/j.fct.2020.111540 .

Baralić, Katarina, Živančević, Katarina, Javorac, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Jorgovanović, Dragica, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats" in Food and Chemical Toxicology, 143 (2020),
https://doi.org/10.1016/j.fct.2020.111540 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Buha-Đorđević, Aleksandra
AU  - Živančević, Katarina
AU  - Antonijević, Evica
AU  - Anđelković, Milena
AU  - Javorac, Dragana
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3499
AB  - Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties, and aect thyroid hormone regulation. The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2 –ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA)) with the effects of their mixture through dierent biochemical, hormonal, and hematological parameters. Rats were divided into five experimental groups: Control (corn oil), DEHP (50 mg/kg b.w./day), DBP (50 mg/kg b.w./day), BPA (25 mg/kg b.w./day), and MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA). Animals were sacrificed after 28 days of oral treatment and blood was collected for further analysis. The results demonstrated that the mixture produced significant changes in lipid profile, liver-related biochemical parameters, and glucose level. Furthermore, the opposite effects of single substances on the thyroxine level have been shown in comparison with the mixture, as well as a more pronounced effect of the mixture on testosterone level. This study contributes to the body of knowledge on the toxicology of mixtures and gives one more evidence of the paramount importance of mixture toxicity studies, especially in assessing the endocrine disruptive effects of chemicals.
PB  - MDPI
T2  - International Journal of Environmental Research and Public Health
T1  - Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats
VL  - 17
IS  - 3
DO  - 10.3390/ijerph17030746
ER  - 

@article{
author = "Baralić, Katarina and Buha-Đorđević, Aleksandra and Živančević, Katarina and Antonijević, Evica and Anđelković, Milena and Javorac, Dragana and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2020",
abstract = "Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties, and aect thyroid hormone regulation. The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2 –ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA)) with the effects of their mixture through dierent biochemical, hormonal, and hematological parameters. Rats were divided into five experimental groups: Control (corn oil), DEHP (50 mg/kg b.w./day), DBP (50 mg/kg b.w./day), BPA (25 mg/kg b.w./day), and MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA). Animals were sacrificed after 28 days of oral treatment and blood was collected for further analysis. The results demonstrated that the mixture produced significant changes in lipid profile, liver-related biochemical parameters, and glucose level. Furthermore, the opposite effects of single substances on the thyroxine level have been shown in comparison with the mixture, as well as a more pronounced effect of the mixture on testosterone level. This study contributes to the body of knowledge on the toxicology of mixtures and gives one more evidence of the paramount importance of mixture toxicity studies, especially in assessing the endocrine disruptive effects of chemicals.",
publisher = "MDPI",
journal = "International Journal of Environmental Research and Public Health",
title = "Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats",
volume = "17",
number = "3",
doi = "10.3390/ijerph17030746"
}

Baralić, K., Buha-Đorđević, A., Živančević, K., Antonijević, E., Anđelković, M., Javorac, D., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2020). Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats. in International Journal of Environmental Research and Public Health
MDPI., 17(3).
https://doi.org/10.3390/ijerph17030746

Baralić K, Buha-Đorđević A, Živančević K, Antonijević E, Anđelković M, Javorac D, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats. in International Journal of Environmental Research and Public Health. 2020;17(3).
doi:10.3390/ijerph17030746 .

Baralić, Katarina, Buha-Đorđević, Aleksandra, Živančević, Katarina, Antonijević, Evica, Anđelković, Milena, Javorac, Dragana, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats" in International Journal of Environmental Research and Public Health, 17, no. 3 (2020),
https://doi.org/10.3390/ijerph17030746 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Javorac, Dragana
AU  - Antonijević, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3644
AB  - This  paper  aims  to  present  the  importance  of  the  benchmark  dose  (BMD)  as  a  point  of departure (the lowest dose or concentration in the experiment that deviates from the response that differs from the normal response) in toxicological risk assessment, as well as to present commonly used software for its calculation (BMDS and PROAST). Benchmark dose is defined as a statistical lower confidence limit of a dose that results in a small change in effect (5-10%) in comparison with the control value. The BMD approach is considered a substitution for the NOAEL approach, which uses the highest observed no-effect level (NOAEL) to obtain the reference dose. The BMD approach is a methodically more forward-thinking technique than the NOAEL approach because it has statistical power and provides a wide range of dose-response relationships and allows the determination of their uncertainty and  variability. Moreover, the  BMD approach contributes to the reduction of experimental animals in toxicity studies. Therefore, the European Food Safety Authority (EFSA) recommends the use of BMDL10values for quantal and BMDL05for continuous data.
AB  - Cilj ovog rada je da predstavi značaj granične benchmark doze (engl. benchmark dose, BMD) kao polaznog doznog nivoa (najniže doze ili koncentracije u eksperimentu koja odstupa od normalnog odgovora) u toksikološkoj proceni rizika, kao i da prikaže najčešće korišćene softvere za njeno izračunavanje (BMDS i PROAST). Benchmark doza predstavlja statističku donju granicu pouzdanosti doze koja dovodi do malog povećanja efekta (5-10%) u odnosu na kontrolnu vrednost. Benchmark pristup predstavlja alternativu NOAEL (engl. no observed adverse effects level, NOAEL) pristupu, u kome se u svrhu dobijanja referentnih vrednosti koristi najviša doza koja ne izaziva štetan efekat. Benchmark pristup naučno je napredniji metod od tradicionalnog NOAEL pristupa, jer je statistički utemeljen, daje širok opseg podataka o odnosu doza-odgovor i omogućava kvantifikaciju njihove nesigurnosti i varijabilnosti. Takođe, BMD pristup doprinosi smanjenju broja eksperimentalnih životinja u toksikološkim studijama. Samim tim, Evropska agencija za bezbednost hrane (EFSA) preporučuje primenu doza BMDL10 za kvantalne i BMDL05 za kontinuirane podatke.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - Relevance and evaluation of the benchmark dose in toxicology
T1  - Značaj i procena benchmark doze u toksikologiji
VL  - 70
IS  - 3
SP  - 130
EP  - 141
DO  - 10.5937/arhfarm2003130B
ER  - 

@article{
author = "Baralić, Katarina and Javorac, Dragana and Antonijević, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana",
year = "2020",
abstract = "This  paper  aims  to  present  the  importance  of  the  benchmark  dose  (BMD)  as  a  point  of departure (the lowest dose or concentration in the experiment that deviates from the response that differs from the normal response) in toxicological risk assessment, as well as to present commonly used software for its calculation (BMDS and PROAST). Benchmark dose is defined as a statistical lower confidence limit of a dose that results in a small change in effect (5-10%) in comparison with the control value. The BMD approach is considered a substitution for the NOAEL approach, which uses the highest observed no-effect level (NOAEL) to obtain the reference dose. The BMD approach is a methodically more forward-thinking technique than the NOAEL approach because it has statistical power and provides a wide range of dose-response relationships and allows the determination of their uncertainty and  variability. Moreover, the  BMD approach contributes to the reduction of experimental animals in toxicity studies. Therefore, the European Food Safety Authority (EFSA) recommends the use of BMDL10values for quantal and BMDL05for continuous data., Cilj ovog rada je da predstavi značaj granične benchmark doze (engl. benchmark dose, BMD) kao polaznog doznog nivoa (najniže doze ili koncentracije u eksperimentu koja odstupa od normalnog odgovora) u toksikološkoj proceni rizika, kao i da prikaže najčešće korišćene softvere za njeno izračunavanje (BMDS i PROAST). Benchmark doza predstavlja statističku donju granicu pouzdanosti doze koja dovodi do malog povećanja efekta (5-10%) u odnosu na kontrolnu vrednost. Benchmark pristup predstavlja alternativu NOAEL (engl. no observed adverse effects level, NOAEL) pristupu, u kome se u svrhu dobijanja referentnih vrednosti koristi najviša doza koja ne izaziva štetan efekat. Benchmark pristup naučno je napredniji metod od tradicionalnog NOAEL pristupa, jer je statistički utemeljen, daje širok opseg podataka o odnosu doza-odgovor i omogućava kvantifikaciju njihove nesigurnosti i varijabilnosti. Takođe, BMD pristup doprinosi smanjenju broja eksperimentalnih životinja u toksikološkim studijama. Samim tim, Evropska agencija za bezbednost hrane (EFSA) preporučuje primenu doza BMDL10 za kvantalne i BMDL05 za kontinuirane podatke.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Relevance and evaluation of the benchmark dose in toxicology, Značaj i procena benchmark doze u toksikologiji",
volume = "70",
number = "3",
pages = "130-141",
doi = "10.5937/arhfarm2003130B"
}

Baralić, K., Javorac, D., Antonijević, E., Buha-Đorđević, A., Ćurčić, M., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2020). Relevance and evaluation of the benchmark dose in toxicology. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 70(3), 130-141.
https://doi.org/10.5937/arhfarm2003130B

Baralić K, Javorac D, Antonijević E, Buha-Đorđević A, Ćurčić M, Đukić-Ćosić D, Bulat Z, Antonijević B. Relevance and evaluation of the benchmark dose in toxicology. in Arhiv za farmaciju. 2020;70(3):130-141.
doi:10.5937/arhfarm2003130B .

Baralić, Katarina, Javorac, Dragana, Antonijević, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "Relevance and evaluation of the benchmark dose in toxicology" in Arhiv za farmaciju, 70, no. 3 (2020):130-141,
https://doi.org/10.5937/arhfarm2003130B . .

TY  - JOUR
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević, Evica
AU  - Ćurčić, Marijana
AU  - Milovanović, Vesna
AU  - Antonijević, Biljana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3470
AB  - The extent of human exposure to chemicals, their endocrine-disrupting mechanisms of action, and the relationship between exposure and various human diseases raise significant scientific and public health concerns. Polychlorinated biphenyls (PCBs) belong to the group of organic compounds known as persistent organic pollutants, characterized by long-range transport, persistence, bioaccumulation, and high toxicity. They have been identified as endocrine-disrupting chemicals. In vivo and in vitro studies have shown that endocrine-disrupting effects of PCBs mainly involve thyroid and reproductive function. In the review presented, these effects were placed in the context of the most recent findings on PCB-induced endocrine-disrupting mechanisms and modes of action.
PB  - Elsevier
T2  - Current Opinion in Toxicology
T1  - Endocrine-disrupting mechanisms of polychlorinated biphenyls
VL  - 19
SP  - 42
EP  - 49
DO  - 10.1016/j.cotox.2019.10.006
ER  - 

@article{
author = "Buha-Đorđević, Aleksandra and Antonijević, Evica and Ćurčić, Marijana and Milovanović, Vesna and Antonijević, Biljana",
year = "2020",
abstract = "The extent of human exposure to chemicals, their endocrine-disrupting mechanisms of action, and the relationship between exposure and various human diseases raise significant scientific and public health concerns. Polychlorinated biphenyls (PCBs) belong to the group of organic compounds known as persistent organic pollutants, characterized by long-range transport, persistence, bioaccumulation, and high toxicity. They have been identified as endocrine-disrupting chemicals. In vivo and in vitro studies have shown that endocrine-disrupting effects of PCBs mainly involve thyroid and reproductive function. In the review presented, these effects were placed in the context of the most recent findings on PCB-induced endocrine-disrupting mechanisms and modes of action.",
publisher = "Elsevier",
journal = "Current Opinion in Toxicology",
title = "Endocrine-disrupting mechanisms of polychlorinated biphenyls",
volume = "19",
pages = "42-49",
doi = "10.1016/j.cotox.2019.10.006"
}

Buha-Đorđević, A., Antonijević, E., Ćurčić, M., Milovanović, V.,& Antonijević, B.. (2020). Endocrine-disrupting mechanisms of polychlorinated biphenyls. in Current Opinion in Toxicology
Elsevier., 19, 42-49.
https://doi.org/10.1016/j.cotox.2019.10.006

Buha-Đorđević A, Antonijević E, Ćurčić M, Milovanović V, Antonijević B. Endocrine-disrupting mechanisms of polychlorinated biphenyls. in Current Opinion in Toxicology. 2020;19:42-49.
doi:10.1016/j.cotox.2019.10.006 .

Buha-Đorđević, Aleksandra, Antonijević, Evica, Ćurčić, Marijana, Milovanović, Vesna, Antonijević, Biljana, "Endocrine-disrupting mechanisms of polychlorinated biphenyls" in Current Opinion in Toxicology, 19 (2020):42-49,
https://doi.org/10.1016/j.cotox.2019.10.006 . .

TY  - JOUR
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Evica
AU  - Mandinić, Zoran
AU  - Ćurčić, Marijana
AU  - Ćupić-Miladinović, Dejana
AU  - Antonijević, Biljana
AU  - Matović, Vesna
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3274
AB  - Background/Aim. Fluoride has beneficial effect on dental caries prevention and enables high hardness of enamel. However, fluoride intake above optimal levels can have adverse effects on teeth and bones, especially in young children during the period of intense growth and teeth development. The aim of this study was to assess fluoride intake from water and toothpaste among 3-year-old children in Belgrade, Serbia, in the municipalities of Vračar and Novi Beograd. Methods. A questionnaire for the parents (n = 40) was used to provide information on the water consumption (tap and/or bottled water) and the brand of toothpaste used by children as well as the frequency of tooth brushing and the amount of toothpaste during brushing. Fluoride concentrations in water and toothpaste samples were determined electrochemically by using fluoride-selective electrode. Fluoride intake was estimated through a mathematical model commonly used by the U.S. Environmental Protection Agency. Results. The obtained results indicate no significant difference in daily fluoride intake through drinking water and toothpaste in 3-year-old children in Vračar (n = 19) compared to Novi Beograd (n = 21) (p > 0.05). However, all estimated fluoride levels (0.089-0.625 mg/day) are significantly lower than the optimal daily intake level for caries protection (0.7 mg/day for children up to 4 years, FNB-USA National Institute of Medicine) and two to six times lower than tolerable upper fluoride level for the children of same age (1.3 mg/day, FNB-USA National Institute of Medicine). Furthermore, calculated daily fluoride intake per kilogram body weight confirm very low fluoride intake by water and toothpaste in children of investigated municipalities in Belgrade, being significantly below the recommended an adequate intake (0.05 mg/kg/day, EFSA). Conclusion. This preliminary study has shown that daily fluoride intake in 3-year-olds is lower than tolerable upper fluoride level, even not sufficient for the prevention of dental caries.
AB  - Uvod/Cilj. Fluoridi imaju pozitivan efekat na prevenciju karijesa zuba kao i povećanje čvrstine zubnog emajla. Međutim, njihov unos iznad optimalnog može imati štetne efekte na zube i kosti, posebno kod male dece tokom intenzivnog rasta i razvoja zuba. Cilj ovog rada bio je da se proceni unos fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine u Beogradu, na teritoriji dve opštine, Vračar i Novi Beograd. Metode. Anketnim upitnicima (n = 40) za roditelje dobijeni su podaci o vrsti vode koju deca piju (česmenska i/ili flaširana), proizvodima koje koriste za čišćenje i negu zuba, učestalosti pranja zuba kao i količini paste za zube koja se koristi po jednom pranju. Sadržaj fluorida u vodi za piće i pastama za zube određen je elektrohemijski sa fluoridnom jonselektivnom elektrodom. Unos fluorida procenjen je korišćenjem matematičkog modela datog od strane Američke agencije za zaštitu životne sredine. Rezultati. Dobijeni rezultati pokazuju da nema statistički značajne razlike u dnevnom unosu fluorida putem vode za piće i paste za zube između dece uzrasta od tri godine na Vračaru i Novom Beogradu (p > 0,05). Međutim, sve procenjene vrednosti unosa fluorida (0,089-0,625 mg/dan) značajno su niže od optimalnog dnevnog unosa za prevenciju karijesa (0,7 mg/dan za decu uzrasta do 4 godine, FNB-Nacionalnog instituta medicine, SAD) i dva do šest puta niže od tolerišućeg gornjeg nivoa unosa fluorida za decu istog uzrasta (1,3 mg/dan, FNBNacionalnog instituta medicine, SAD). Štaviše, izračunati dnevni unosi fluorida izraženi po kilogramu telesne mase potvrđuju veoma nizak unos fluorida kod dece ispitivanih opština u Beogradu, čak značajno niže od preporučenog optimalnog unosa (0,05 mg/kg/dan, EFSA). Zaključak. Ovim preliminarnim istraživanjem pokazano je da je dnevni unos fluorida kod trogodišnjaka u Beogradu značajno niži od tolerišućeg gornjeg nivoa unosa fluorida, čak niži od optimalnog unosa za prevenciju karijesa.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia
T1  - Procena unosa fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine - preliminarni rezultati u Beogradu, Republika Srbija
VL  - 76
IS  - 6
SP  - 607
EP  - 614
DO  - 10.2298/VSP170721136D
ER  - 

@article{
author = "Đukić-Ćosić, Danijela and Antonijević, Evica and Mandinić, Zoran and Ćurčić, Marijana and Ćupić-Miladinović, Dejana and Antonijević, Biljana and Matović, Vesna",
year = "2019",
abstract = "Background/Aim. Fluoride has beneficial effect on dental caries prevention and enables high hardness of enamel. However, fluoride intake above optimal levels can have adverse effects on teeth and bones, especially in young children during the period of intense growth and teeth development. The aim of this study was to assess fluoride intake from water and toothpaste among 3-year-old children in Belgrade, Serbia, in the municipalities of Vračar and Novi Beograd. Methods. A questionnaire for the parents (n = 40) was used to provide information on the water consumption (tap and/or bottled water) and the brand of toothpaste used by children as well as the frequency of tooth brushing and the amount of toothpaste during brushing. Fluoride concentrations in water and toothpaste samples were determined electrochemically by using fluoride-selective electrode. Fluoride intake was estimated through a mathematical model commonly used by the U.S. Environmental Protection Agency. Results. The obtained results indicate no significant difference in daily fluoride intake through drinking water and toothpaste in 3-year-old children in Vračar (n = 19) compared to Novi Beograd (n = 21) (p > 0.05). However, all estimated fluoride levels (0.089-0.625 mg/day) are significantly lower than the optimal daily intake level for caries protection (0.7 mg/day for children up to 4 years, FNB-USA National Institute of Medicine) and two to six times lower than tolerable upper fluoride level for the children of same age (1.3 mg/day, FNB-USA National Institute of Medicine). Furthermore, calculated daily fluoride intake per kilogram body weight confirm very low fluoride intake by water and toothpaste in children of investigated municipalities in Belgrade, being significantly below the recommended an adequate intake (0.05 mg/kg/day, EFSA). Conclusion. This preliminary study has shown that daily fluoride intake in 3-year-olds is lower than tolerable upper fluoride level, even not sufficient for the prevention of dental caries., Uvod/Cilj. Fluoridi imaju pozitivan efekat na prevenciju karijesa zuba kao i povećanje čvrstine zubnog emajla. Međutim, njihov unos iznad optimalnog može imati štetne efekte na zube i kosti, posebno kod male dece tokom intenzivnog rasta i razvoja zuba. Cilj ovog rada bio je da se proceni unos fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine u Beogradu, na teritoriji dve opštine, Vračar i Novi Beograd. Metode. Anketnim upitnicima (n = 40) za roditelje dobijeni su podaci o vrsti vode koju deca piju (česmenska i/ili flaširana), proizvodima koje koriste za čišćenje i negu zuba, učestalosti pranja zuba kao i količini paste za zube koja se koristi po jednom pranju. Sadržaj fluorida u vodi za piće i pastama za zube određen je elektrohemijski sa fluoridnom jonselektivnom elektrodom. Unos fluorida procenjen je korišćenjem matematičkog modela datog od strane Američke agencije za zaštitu životne sredine. Rezultati. Dobijeni rezultati pokazuju da nema statistički značajne razlike u dnevnom unosu fluorida putem vode za piće i paste za zube između dece uzrasta od tri godine na Vračaru i Novom Beogradu (p > 0,05). Međutim, sve procenjene vrednosti unosa fluorida (0,089-0,625 mg/dan) značajno su niže od optimalnog dnevnog unosa za prevenciju karijesa (0,7 mg/dan za decu uzrasta do 4 godine, FNB-Nacionalnog instituta medicine, SAD) i dva do šest puta niže od tolerišućeg gornjeg nivoa unosa fluorida za decu istog uzrasta (1,3 mg/dan, FNBNacionalnog instituta medicine, SAD). Štaviše, izračunati dnevni unosi fluorida izraženi po kilogramu telesne mase potvrđuju veoma nizak unos fluorida kod dece ispitivanih opština u Beogradu, čak značajno niže od preporučenog optimalnog unosa (0,05 mg/kg/dan, EFSA). Zaključak. Ovim preliminarnim istraživanjem pokazano je da je dnevni unos fluorida kod trogodišnjaka u Beogradu značajno niži od tolerišućeg gornjeg nivoa unosa fluorida, čak niži od optimalnog unosa za prevenciju karijesa.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia, Procena unosa fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine - preliminarni rezultati u Beogradu, Republika Srbija",
volume = "76",
number = "6",
pages = "607-614",
doi = "10.2298/VSP170721136D"
}

Đukić-Ćosić, D., Antonijević, E., Mandinić, Z., Ćurčić, M., Ćupić-Miladinović, D., Antonijević, B.,& Matović, V.. (2019). Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(6), 607-614.
https://doi.org/10.2298/VSP170721136D

Đukić-Ćosić D, Antonijević E, Mandinić Z, Ćurčić M, Ćupić-Miladinović D, Antonijević B, Matović V. Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia. in Vojnosanitetski pregled. 2019;76(6):607-614.
doi:10.2298/VSP170721136D .

Đukić-Ćosić, Danijela, Antonijević, Evica, Mandinić, Zoran, Ćurčić, Marijana, Ćupić-Miladinović, Dejana, Antonijević, Biljana, Matović, Vesna, "Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia" in Vojnosanitetski pregled, 76, no. 6 (2019):607-614,
https://doi.org/10.2298/VSP170721136D . .

TY  - JOUR
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević, Evica
AU  - Antonijević, Biljana
AU  - Stanić, Momcilo
AU  - Kotur-Stevuljević, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jovanović, Miloš
AU  - Boricić, Novica
AU  - Wallace, David
AU  - Bulat, Zorica
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3301
AB  - Background: Cadmium and lead are widespread and non-biodegradable pollutants of great concern to human health. In real life scenarios, we are exposed to mixtures of chemicals rather than single chemicals, and it is therefore of paramount importance to assess their toxicity. In this study, we investigated the toxicity of Cd and Pb alone and as a mixture in an animal model of acute exposure. Methods: Experimental groups received a single treatment of aqueous solution of Cd-chloride (15 and 30 mg/kg body weight (b.w.) and Pb-acetate (150 mg/kg b.w.), while the mixture group received 15 mg Cd/kg b.w. and 150 mg Pb/kg b.w. Toxic effects of individual metals and their mixture were investigated on hematological and biochemical parameters, and the redox status in the plasma, liver, and kidneys of treated Wistar rats. Results: Tissue-specific changes were recorded in various parameters of oxidative damage, while the accumulation of metals in tissues accompanied the disturbances of both hematological and biochemical parameters. It was observed that the level of toxic metals in tissues had a different distribution pattern after mixture and single exposure. Conclusions: Comprehensive observations suggest that exposure to Cd and Pb mixtures produces more pronounced effects compared to the response observed after exposure to single metal solutions. However, further research is needed to confirm toxicokinetic or toxicodynamic interactions between these two toxic metals in the organisms.
PB  - MDPI, Basel
T2  - International Journal of Environmental Research and Public Health
T1  - Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney
VL  - 16
IS  - 2
DO  - 10.3390/ijerph16020274
ER  - 

@article{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Antonijević, Evica and Antonijević, Biljana and Stanić, Momcilo and Kotur-Stevuljević, Jelena and Spasojević-Kalimanovska, Vesna and Jovanović, Miloš and Boricić, Novica and Wallace, David and Bulat, Zorica",
year = "2019",
abstract = "Background: Cadmium and lead are widespread and non-biodegradable pollutants of great concern to human health. In real life scenarios, we are exposed to mixtures of chemicals rather than single chemicals, and it is therefore of paramount importance to assess their toxicity. In this study, we investigated the toxicity of Cd and Pb alone and as a mixture in an animal model of acute exposure. Methods: Experimental groups received a single treatment of aqueous solution of Cd-chloride (15 and 30 mg/kg body weight (b.w.) and Pb-acetate (150 mg/kg b.w.), while the mixture group received 15 mg Cd/kg b.w. and 150 mg Pb/kg b.w. Toxic effects of individual metals and their mixture were investigated on hematological and biochemical parameters, and the redox status in the plasma, liver, and kidneys of treated Wistar rats. Results: Tissue-specific changes were recorded in various parameters of oxidative damage, while the accumulation of metals in tissues accompanied the disturbances of both hematological and biochemical parameters. It was observed that the level of toxic metals in tissues had a different distribution pattern after mixture and single exposure. Conclusions: Comprehensive observations suggest that exposure to Cd and Pb mixtures produces more pronounced effects compared to the response observed after exposure to single metal solutions. However, further research is needed to confirm toxicokinetic or toxicodynamic interactions between these two toxic metals in the organisms.",
publisher = "MDPI, Basel",
journal = "International Journal of Environmental Research and Public Health",
title = "Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney",
volume = "16",
number = "2",
doi = "10.3390/ijerph16020274"
}

Anđelković, M., Buha-Đorđević, A., Antonijević, E., Antonijević, B., Stanić, M., Kotur-Stevuljević, J., Spasojević-Kalimanovska, V., Jovanović, M., Boricić, N., Wallace, D.,& Bulat, Z.. (2019). Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney. in International Journal of Environmental Research and Public Health
MDPI, Basel., 16(2).
https://doi.org/10.3390/ijerph16020274

Anđelković M, Buha-Đorđević A, Antonijević E, Antonijević B, Stanić M, Kotur-Stevuljević J, Spasojević-Kalimanovska V, Jovanović M, Boricić N, Wallace D, Bulat Z. Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney. in International Journal of Environmental Research and Public Health. 2019;16(2).
doi:10.3390/ijerph16020274 .

Anđelković, Milena, Buha-Đorđević, Aleksandra, Antonijević, Evica, Antonijević, Biljana, Stanić, Momcilo, Kotur-Stevuljević, Jelena, Spasojević-Kalimanovska, Vesna, Jovanović, Miloš, Boricić, Novica, Wallace, David, Bulat, Zorica, "Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney" in International Journal of Environmental Research and Public Health, 16, no. 2 (2019),
https://doi.org/10.3390/ijerph16020274 . .

TY  - JOUR
AU  - Antonijević, Evica
AU  - Musilek, Kamil
AU  - Kuca, Kamil
AU  - Đukić-Ćosić, Danijela
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević, Biljana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3249
PB  - Elsevier Ireland Ltd, Clare
T2  - Chemico-Biological Interactions
T1  - Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation
VL  - 308
SP  - 385
EP  - 391
DO  - 10.1016/j.cbi.2019.05.034
ER  - 

@article{
author = "Antonijević, Evica and Musilek, Kamil and Kuca, Kamil and Đukić-Ćosić, Danijela and Anđelković, Milena and Buha-Đorđević, Aleksandra and Antonijević, Biljana",
year = "2019",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Chemico-Biological Interactions",
title = "Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation",
volume = "308",
pages = "385-391",
doi = "10.1016/j.cbi.2019.05.034"
}

Antonijević, E., Musilek, K., Kuca, K., Đukić-Ćosić, D., Anđelković, M., Buha-Đorđević, A.,& Antonijević, B.. (2019). Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation. in Chemico-Biological Interactions
Elsevier Ireland Ltd, Clare., 308, 385-391.
https://doi.org/10.1016/j.cbi.2019.05.034

Antonijević E, Musilek K, Kuca K, Đukić-Ćosić D, Anđelković M, Buha-Đorđević A, Antonijević B. Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation. in Chemico-Biological Interactions. 2019;308:385-391.
doi:10.1016/j.cbi.2019.05.034 .

Antonijević, Evica, Musilek, Kamil, Kuca, Kamil, Đukić-Ćosić, Danijela, Anđelković, Milena, Buha-Đorđević, Aleksandra, Antonijević, Biljana, "Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation" in Chemico-Biological Interactions, 308 (2019):385-391,
https://doi.org/10.1016/j.cbi.2019.05.034 . .

TY  - THES
AU  - Antonijević, Evica
PY  - 2019
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=7318
UR  - http://nardus.mpn.gov.rs/handle/123456789/12164
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:21218/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=2048408674
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3691
AB  - Standardna  terapija  akutnog  trovanja  ljudi  organofosfornim  (OF) jedinjenjimasastoji se od leka sa antiholinergičkim efektom (atropin) i reaktivatora inhibirane acetilholinesteraze(AChE)(oksim). Međutim, eksperimentalne i kliničke studije pokazale su nezadovoljavajuću i/ili nejednaku efikasnost postojećih oksima kod strukturno  različitih OF. Među  eksperimentalnim  oksimima  po  svojoj efikasnostiizdvojili su se oksimi K203 i K027,koji do sada nisu in vivo testirani na modelu pesticida. Stoga je cilj istraživanja bio da se ispita njihova potencijalnaterapijska i reaktivatorska  efikasnost,  kao  i  antioksidativni  kapacitet  kod  pacova  akutno trovanih  dihlorvosom.U  cilju  poređenja, ispitivanja  antidotske  efikasnosti sprovedena su pod istim eksperimentalnim uslovima i sa standardnim oksimima.Najbolji antidotski efekat dobijen je nakon primene oksima K027. Efikasnost drugih ispitivanih  oksima  opadala  je  sledećim  redosledom  obidoksim>K203> trimedoksim>pralidoksim>azoksim.  Oksim  K027  je  sam  i  u  kombinaciji  sa atropinom  jedini  doveo  do  značajne  reaktivacije  AChE  eritrocita  i  dijafragme.Ekviefektivne doze oksima K027 bile su niže od ekviefektivnih doza oksima K203,dok jenajniža doza oksima K027 bila potrebnaza reaktivaciju AChE dijafragme. Analizom dozne zavisnosti antioksidativnog efekta dobijeno je da je oksim K203 značajno efikasniji u odnosu na oksim K027, pri čemu je najveća razlika u efikasnostiuočena za efekat smanjenja lipidne peroksidacijeu plazmi, iza efekat smanjenja superoksidnog anjonau dijafragmi i mozgu. Rezultati  ove doktorske  disertacijeukazuju  na  bolji  antidotski  potencijal oksima  K027  u  odnosu  na  oksim  K203 što  podržava  hipotezu  oobećavajućoj hemijskoj strukturi oksima K027, vrednoj budućih in vivoispitivanja kod strukturno različitih OF pesticida.
AB  - Standard therapy for acute human poisoning with organophosphorus (OP) compounds  consistsof  anticholinergic  drug  (atropine)andreactivator  of  OP-inhibited acetylcholinesterase (AChE) (oxime). However, experimentalandclinical studies have shown insufficient and/or unequal efficacy of current oximes against poisonings caused by structurally differentOPs. Among the experimental oximes, oximes K203andK027, have shown promising results, but theyhave not yet been tested in vivousing pesticide model. Therefore, the aim of the study was to examine their potential therapeuticandreactivating efficacy as well as antioxidant capacity in rats acutely poisoned with dichlorvos. For the sake of comparison, the study was also carried out with standardly usedoximes under the same experimental protocol. The best antidotal effect was obtained after administration of oxime K027. The efficacy  of  other  investigated  oximes  decreased  in  the  following  order: obidoxime>K203>trimedoxime>pralidoxime>asoxime.  Oxime  K027  aloneand in combination  with  atropine  led  to  a  significant  reactivation  of  erythrocyteanddiaphragm AChE. The equieffective doses of oxime K027 were lower compared to oxime  K203,  while  the  lowest  K027  dose  was  required  for  the  reactivation  of diaphragm AChE. Evaluation of dose-response relationship for antioxidant effect has shown that the oxime K203 was significantly more effective compared to K027, with the greatest difference in efficacy for the lipid peroxidation attenuation in plasmaandreduction of superoxide anion radicals in the diaphragmandbrain tissues. The results of this doctoral dissertation indicate a better antidotal potential of  oxime  K027  compared  to  oxime  K203,  supportingthe  hypothesis  on  the promising chemical structure of oxime K027, worth of future in vivotesting withstructurally different OP pesticides.
PB  - Универзитет у Београду, Фармацеутски факултет
T2  - Универзитет у Београду
T1  - Antidotska efikasnost novosintetisanih oksima K203 i K027 kod pacova akutno trovanih dihlorvosom
UR  - https://hdl.handle.net/21.15107/rcub_nardus_12164
ER  - 

@phdthesis{
author = "Antonijević, Evica",
year = "2019",
abstract = "Standardna  terapija  akutnog  trovanja  ljudi  organofosfornim  (OF) jedinjenjimasastoji se od leka sa antiholinergičkim efektom (atropin) i reaktivatora inhibirane acetilholinesteraze(AChE)(oksim). Međutim, eksperimentalne i kliničke studije pokazale su nezadovoljavajuću i/ili nejednaku efikasnost postojećih oksima kod strukturno  različitih OF. Među  eksperimentalnim  oksimima  po  svojoj efikasnostiizdvojili su se oksimi K203 i K027,koji do sada nisu in vivo testirani na modelu pesticida. Stoga je cilj istraživanja bio da se ispita njihova potencijalnaterapijska i reaktivatorska  efikasnost,  kao  i  antioksidativni  kapacitet  kod  pacova  akutno trovanih  dihlorvosom.U  cilju  poređenja, ispitivanja  antidotske  efikasnosti sprovedena su pod istim eksperimentalnim uslovima i sa standardnim oksimima.Najbolji antidotski efekat dobijen je nakon primene oksima K027. Efikasnost drugih ispitivanih  oksima  opadala  je  sledećim  redosledom  obidoksim>K203> trimedoksim>pralidoksim>azoksim.  Oksim  K027  je  sam  i  u  kombinaciji  sa atropinom  jedini  doveo  do  značajne  reaktivacije  AChE  eritrocita  i  dijafragme.Ekviefektivne doze oksima K027 bile su niže od ekviefektivnih doza oksima K203,dok jenajniža doza oksima K027 bila potrebnaza reaktivaciju AChE dijafragme. Analizom dozne zavisnosti antioksidativnog efekta dobijeno je da je oksim K203 značajno efikasniji u odnosu na oksim K027, pri čemu je najveća razlika u efikasnostiuočena za efekat smanjenja lipidne peroksidacijeu plazmi, iza efekat smanjenja superoksidnog anjonau dijafragmi i mozgu. Rezultati  ove doktorske  disertacijeukazuju  na  bolji  antidotski  potencijal oksima  K027  u  odnosu  na  oksim  K203 što  podržava  hipotezu  oobećavajućoj hemijskoj strukturi oksima K027, vrednoj budućih in vivoispitivanja kod strukturno različitih OF pesticida., Standard therapy for acute human poisoning with organophosphorus (OP) compounds  consistsof  anticholinergic  drug  (atropine)andreactivator  of  OP-inhibited acetylcholinesterase (AChE) (oxime). However, experimentalandclinical studies have shown insufficient and/or unequal efficacy of current oximes against poisonings caused by structurally differentOPs. Among the experimental oximes, oximes K203andK027, have shown promising results, but theyhave not yet been tested in vivousing pesticide model. Therefore, the aim of the study was to examine their potential therapeuticandreactivating efficacy as well as antioxidant capacity in rats acutely poisoned with dichlorvos. For the sake of comparison, the study was also carried out with standardly usedoximes under the same experimental protocol. The best antidotal effect was obtained after administration of oxime K027. The efficacy  of  other  investigated  oximes  decreased  in  the  following  order: obidoxime>K203>trimedoxime>pralidoxime>asoxime.  Oxime  K027  aloneand in combination  with  atropine  led  to  a  significant  reactivation  of  erythrocyteanddiaphragm AChE. The equieffective doses of oxime K027 were lower compared to oxime  K203,  while  the  lowest  K027  dose  was  required  for  the  reactivation  of diaphragm AChE. Evaluation of dose-response relationship for antioxidant effect has shown that the oxime K203 was significantly more effective compared to K027, with the greatest difference in efficacy for the lipid peroxidation attenuation in plasmaandreduction of superoxide anion radicals in the diaphragmandbrain tissues. The results of this doctoral dissertation indicate a better antidotal potential of  oxime  K027  compared  to  oxime  K203,  supportingthe  hypothesis  on  the promising chemical structure of oxime K027, worth of future in vivotesting withstructurally different OP pesticides.",
publisher = "Универзитет у Београду, Фармацеутски факултет",
journal = "Универзитет у Београду",
title = "Antidotska efikasnost novosintetisanih oksima K203 i K027 kod pacova akutno trovanih dihlorvosom",
url = "https://hdl.handle.net/21.15107/rcub_nardus_12164"
}

Antonijević, E.. (2019). Antidotska efikasnost novosintetisanih oksima K203 i K027 kod pacova akutno trovanih dihlorvosom. in Универзитет у Београду
Универзитет у Београду, Фармацеутски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_12164

Antonijević E. Antidotska efikasnost novosintetisanih oksima K203 i K027 kod pacova akutno trovanih dihlorvosom. in Универзитет у Београду. 2019;.
https://hdl.handle.net/21.15107/rcub_nardus_12164 .

Antonijević, Evica, "Antidotska efikasnost novosintetisanih oksima K203 i K027 kod pacova akutno trovanih dihlorvosom" in Универзитет у Београду (2019),
https://hdl.handle.net/21.15107/rcub_nardus_12164 .

TY  - CONF
AU  - Baralić, Katarina
AU  - Jorgovanović, D.
AU  - Matović, Vesna
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
AU  - Ćurčić, Marijana
AU  - Antonijević, Evica
AU  - Đukić-Ćosić, Danijela
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3132
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Toxicogenomics analysis of phthalates and bisphenol A mixture: Obesity and comorbidities
VL  - 295
IS  - Supplement 1
SP  - S237
EP  - S237
DO  - 10.1016/j.toxlet.2018.06.988
ER  - 

@conference{
author = "Baralić, Katarina and Jorgovanović, D. and Matović, Vesna and Antonijević, Biljana and Bulat, Zorica and Ćurčić, Marijana and Antonijević, Evica and Đukić-Ćosić, Danijela",
year = "2018",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Toxicogenomics analysis of phthalates and bisphenol A mixture: Obesity and comorbidities",
volume = "295",
number = "Supplement 1",
pages = "S237-S237",
doi = "10.1016/j.toxlet.2018.06.988"
}

Baralić, K., Jorgovanović, D., Matović, V., Antonijević, B., Bulat, Z., Ćurčić, M., Antonijević, E.,& Đukić-Ćosić, D.. (2018). Toxicogenomics analysis of phthalates and bisphenol A mixture: Obesity and comorbidities. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 295(Supplement 1), S237-S237.
https://doi.org/10.1016/j.toxlet.2018.06.988

Baralić K, Jorgovanović D, Matović V, Antonijević B, Bulat Z, Ćurčić M, Antonijević E, Đukić-Ćosić D. Toxicogenomics analysis of phthalates and bisphenol A mixture: Obesity and comorbidities. in Toxicology Letters. 2018;295(Supplement 1):S237-S237.
doi:10.1016/j.toxlet.2018.06.988 .

Baralić, Katarina, Jorgovanović, D., Matović, Vesna, Antonijević, Biljana, Bulat, Zorica, Ćurčić, Marijana, Antonijević, Evica, Đukić-Ćosić, Danijela, "Toxicogenomics analysis of phthalates and bisphenol A mixture: Obesity and comorbidities" in Toxicology Letters, 295, no. Supplement 1 (2018):S237-S237,
https://doi.org/10.1016/j.toxlet.2018.06.988 . .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Buha-Đorđević, Aleksandra
AU  - Milovanović, V.
AU  - Janković, Saša
AU  - Vučinić, Slavica
AU  - Antonijević, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Matović, Vesna
AU  - Antonijević, Biljana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3126
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneys
VL  - 295
IS  - Supplement 1
SP  - S235
EP  - S236
DO  - 10.1016/j.toxlet.2018.06.984
ER  - 

@conference{
author = "Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Milovanović, V. and Janković, Saša and Vučinić, Slavica and Antonijević, Evica and Đukić-Ćosić, Danijela and Bulat, Zorica and Matović, Vesna and Antonijević, Biljana",
year = "2018",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneys",
volume = "295",
number = "Supplement 1",
pages = "S235-S236",
doi = "10.1016/j.toxlet.2018.06.984"
}

Ćurčić, M., Buha-Đorđević, A., Milovanović, V., Janković, S., Vučinić, S., Antonijević, E., Đukić-Ćosić, D., Bulat, Z., Matović, V.,& Antonijević, B.. (2018). Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneys. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 295(Supplement 1), S235-S236.
https://doi.org/10.1016/j.toxlet.2018.06.984

Ćurčić M, Buha-Đorđević A, Milovanović V, Janković S, Vučinić S, Antonijević E, Đukić-Ćosić D, Bulat Z, Matović V, Antonijević B. Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneys. in Toxicology Letters. 2018;295(Supplement 1):S235-S236.
doi:10.1016/j.toxlet.2018.06.984 .

Ćurčić, Marijana, Buha-Đorđević, Aleksandra, Milovanović, V., Janković, Saša, Vučinić, Slavica, Antonijević, Evica, Đukić-Ćosić, Danijela, Bulat, Zorica, Matović, Vesna, Antonijević, Biljana, "Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneys" in Toxicology Letters, 295, no. Supplement 1 (2018):S235-S236,
https://doi.org/10.1016/j.toxlet.2018.06.984 . .

TY  - JOUR
AU  - Antonijević, Evica
AU  - Kotur-Stevuljević, Jelena
AU  - Musilek, Kamil
AU  - Kosvancova, Andrea
AU  - Kuca, Kamil
AU  - Đukić-Ćosić, Danijela
AU  - Spasojević-Kalimanovska, Vesna
AU  - Antonijević, Biljana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3170
AB  - Beside the key inhibition of acetylcholinesterase (AChE), involvement of oxidative stress in organophosphate (OP)-induced toxicity has been supported by experimental and human studies. On the other hand, according to our best knowledge, possible antioxidant properties of oximes, the only causal antidotes to OP-inhibited AChE, have been examined only by a few studies. Thus, we have determined the effect of four conventional (obidoxime, trimedoxime, pralidoxime, asoxime) and two promising experimental oximes (K027, K203) on dichlorvos (DDVP)-induced oxidative changes in vivo. Wistar rats (5/group) were treated with oxime (5% LD50 i.m) immediately after DDVP challenge (75% LD50 s.c). Oxidative stress biomarkers were determined in plasma and brain 60 min after the treatment: prooxidative-superoxide anion (O-2 (center dot-)) and total oxidative status (TOS); antioxidative-superoxide dismutase (SOD), total thiol (SH) groups, total antioxidant status (TAS) and paraoxonase (PON1); tissue oxidative stress burden-prooxidative-antioxidative balance (PAB) and oxidative stress index (OSI); oxidative tissue damage-malondialdehyde (MDA) and advanced oxidation protein products (AOPP). All oximes were able to attenuate DDVP-induced oxidative stress in rat plasma and brain. Changes of determined parameters in brain were not as prominent as it was seen in plasma. Based on OSI, better abilities of oxime K027, K203 and obidoxime to maintain DDVP-induced oxidative stress in rat brain were shown as compared to trimedoxime, pralidoxime and asoxime. Oximes can influence the complex in vivo redox processes that might contribute to their overall therapeutic efficacy. Further research is needed to understand the underlying molecular mechanisms involved in this phenomenon.
PB  - Springer Heidelberg, Heidelberg
T2  - Archives of Toxicology
T1  - Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain
VL  - 92
IS  - 2
SP  - 745
EP  - 757
DO  - 10.1007/s00204-017-2101-z
ER  - 

@article{
author = "Antonijević, Evica and Kotur-Stevuljević, Jelena and Musilek, Kamil and Kosvancova, Andrea and Kuca, Kamil and Đukić-Ćosić, Danijela and Spasojević-Kalimanovska, Vesna and Antonijević, Biljana",
year = "2018",
abstract = "Beside the key inhibition of acetylcholinesterase (AChE), involvement of oxidative stress in organophosphate (OP)-induced toxicity has been supported by experimental and human studies. On the other hand, according to our best knowledge, possible antioxidant properties of oximes, the only causal antidotes to OP-inhibited AChE, have been examined only by a few studies. Thus, we have determined the effect of four conventional (obidoxime, trimedoxime, pralidoxime, asoxime) and two promising experimental oximes (K027, K203) on dichlorvos (DDVP)-induced oxidative changes in vivo. Wistar rats (5/group) were treated with oxime (5% LD50 i.m) immediately after DDVP challenge (75% LD50 s.c). Oxidative stress biomarkers were determined in plasma and brain 60 min after the treatment: prooxidative-superoxide anion (O-2 (center dot-)) and total oxidative status (TOS); antioxidative-superoxide dismutase (SOD), total thiol (SH) groups, total antioxidant status (TAS) and paraoxonase (PON1); tissue oxidative stress burden-prooxidative-antioxidative balance (PAB) and oxidative stress index (OSI); oxidative tissue damage-malondialdehyde (MDA) and advanced oxidation protein products (AOPP). All oximes were able to attenuate DDVP-induced oxidative stress in rat plasma and brain. Changes of determined parameters in brain were not as prominent as it was seen in plasma. Based on OSI, better abilities of oxime K027, K203 and obidoxime to maintain DDVP-induced oxidative stress in rat brain were shown as compared to trimedoxime, pralidoxime and asoxime. Oximes can influence the complex in vivo redox processes that might contribute to their overall therapeutic efficacy. Further research is needed to understand the underlying molecular mechanisms involved in this phenomenon.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Archives of Toxicology",
title = "Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain",
volume = "92",
number = "2",
pages = "745-757",
doi = "10.1007/s00204-017-2101-z"
}

Antonijević, E., Kotur-Stevuljević, J., Musilek, K., Kosvancova, A., Kuca, K., Đukić-Ćosić, D., Spasojević-Kalimanovska, V.,& Antonijević, B.. (2018). Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain. in Archives of Toxicology
Springer Heidelberg, Heidelberg., 92(2), 745-757.
https://doi.org/10.1007/s00204-017-2101-z

Antonijević E, Kotur-Stevuljević J, Musilek K, Kosvancova A, Kuca K, Đukić-Ćosić D, Spasojević-Kalimanovska V, Antonijević B. Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain. in Archives of Toxicology. 2018;92(2):745-757.
doi:10.1007/s00204-017-2101-z .

Antonijević, Evica, Kotur-Stevuljević, Jelena, Musilek, Kamil, Kosvancova, Andrea, Kuca, Kamil, Đukić-Ćosić, Danijela, Spasojević-Kalimanovska, Vesna, Antonijević, Biljana, "Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain" in Archives of Toxicology, 92, no. 2 (2018):745-757,
https://doi.org/10.1007/s00204-017-2101-z . .

TY  - JOUR
AU  - Antonijević, Evica
AU  - Musilek, Kamil
AU  - Kuca, Kamil
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Čupić-Miladinović, Dejana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3055
AB  - Inhibition of acethylcholinesterase (AChE) as a key molecular event induced by organophosphate (OP) pesticides and nerve agents presents a human health concern. In efficacy testing of experimental oximes, potential antidotes in OP poisoning, reactivation of OP-inhibited AChE is used as specific endpoint. However, according to our best knowledge, so far oximes have not been quantitatively evaluated by comprehensive benchmark dose (BMD) approach, that would improve both identification and quantification of the effect and allow more rigorous comparison of efficacies. Thus, we have examined in vivo dose-response relationship for two promising experimental oximes, K203 and K027, concerning reactivation of erythrocyte AChE inhibited by dichlorvos (DDVP). Groups of Wistar rats were treated with six different doses of oximes (i.m) immediately after DDVP challenge (s.c) and AChE was measured 60 min later. Dose-response modeling was done by PROAST software 65.5 (RIVM, The Nederlands). BMD-covariate method resulted in four-parameter model from both exponential and Hill model families as the best estimate of relationship between AChE activity and oxime dose, with potency parameter being oxime-dependent. Oxime K027 was shown to be 1.929-fold more potent considering that 58% increase in AChE activity was achived with the dose BMD58-K027 = 52 mu mol/kg in contrast to BMD58-K203 = 100 mu mol/kg.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes
VL  - 121
SP  - 224
EP  - 230
DO  - 10.1016/j.fct.2018.08.065
ER  - 

@article{
author = "Antonijević, Evica and Musilek, Kamil and Kuca, Kamil and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Čupić-Miladinović, Dejana and Bulat, Zorica and Antonijević, Biljana",
year = "2018",
abstract = "Inhibition of acethylcholinesterase (AChE) as a key molecular event induced by organophosphate (OP) pesticides and nerve agents presents a human health concern. In efficacy testing of experimental oximes, potential antidotes in OP poisoning, reactivation of OP-inhibited AChE is used as specific endpoint. However, according to our best knowledge, so far oximes have not been quantitatively evaluated by comprehensive benchmark dose (BMD) approach, that would improve both identification and quantification of the effect and allow more rigorous comparison of efficacies. Thus, we have examined in vivo dose-response relationship for two promising experimental oximes, K203 and K027, concerning reactivation of erythrocyte AChE inhibited by dichlorvos (DDVP). Groups of Wistar rats were treated with six different doses of oximes (i.m) immediately after DDVP challenge (s.c) and AChE was measured 60 min later. Dose-response modeling was done by PROAST software 65.5 (RIVM, The Nederlands). BMD-covariate method resulted in four-parameter model from both exponential and Hill model families as the best estimate of relationship between AChE activity and oxime dose, with potency parameter being oxime-dependent. Oxime K027 was shown to be 1.929-fold more potent considering that 58% increase in AChE activity was achived with the dose BMD58-K027 = 52 mu mol/kg in contrast to BMD58-K203 = 100 mu mol/kg.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes",
volume = "121",
pages = "224-230",
doi = "10.1016/j.fct.2018.08.065"
}

Antonijević, E., Musilek, K., Kuca, K., Đukić-Ćosić, D., Ćurčić, M., Čupić-Miladinović, D., Bulat, Z.,& Antonijević, B.. (2018). Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 121, 224-230.
https://doi.org/10.1016/j.fct.2018.08.065

Antonijević E, Musilek K, Kuca K, Đukić-Ćosić D, Ćurčić M, Čupić-Miladinović D, Bulat Z, Antonijević B. Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes. in Food and Chemical Toxicology. 2018;121:224-230.
doi:10.1016/j.fct.2018.08.065 .

Antonijević, Evica, Musilek, Kamil, Kuca, Kamil, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Čupić-Miladinović, Dejana, Bulat, Zorica, Antonijević, Biljana, "Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes" in Food and Chemical Toxicology, 121 (2018):224-230,
https://doi.org/10.1016/j.fct.2018.08.065 . .