@conference{
author = "Repić, Aleksandra and Lukić, Vera and Ždrale, Branislava and Javorac, Dragana and Bulat, Petar and Bulat, Zorica",
year = "2022",
abstract = "The microelements chromium, cobalt and nickel are necessary for the proper
functioning of the organism. At higher concentrations, they can cause toxic effects (organ
disfunction, genetic damage). They are widespread in the enviroment. They reach our body
through food, water, air and/or skin. The aim of this study was to determine the reference
values of chromium, cobalt and nickel in the blood of adult residents of Belgrade and
determine the degree of influence of individual, socioeconomic factors and lifestyle habits on
blood levels of these metals. The study population consisted of adults, healthy population, 18
to 65 years of age, who were voluntary blood donors. The study included 715 men (72.7%)
and 269 women (27.3%). Blood collected in vacutainers with heparin, was used for analysis.
984 samples were analysed. The metals were determined using inductively coupled plasma
mass spectrometry (7700x, Agilent, USA), with octopol reactive system and micro-flow
nebulizer. The average age of participants was 37.2 10.8. The reference values of the
analysed metals, shown as the 95 percentile, were 0.95µg/L, 0.62µg/L and 1.46µg/L for
chromium, cobalt and nickel, respectively, and were in good correlation with the values
obtained in biomonitoring studies conducted in Europe. This study showed that population
of Serbian origin had significantly lower blood concentrations of chromium, that cobalt blood
levels in women were significantly higher and cobalt and nickel levels increased with age in
both sexes. Education and economic status, cigarette smoking and sports did not significantly
affect the levels of these metals in the blood., Mikroelementi hrom, kobalt i nikl su potrebni za pravilno funkcionisanje organizma. U
većim koncentracijama mogu ispoljiti toksične efekte poput ometanja pravilne funkcije
organa i dovesti do genetskih oštećenja i karcinogeneze. Široko su rasprostranjeni u životnoj
sredini. Putem hrane, vode, vazduha i/ili kože dospevaju u naš organizam. Cilj rada bio je da
se utvrde referentne vrednosti hroma, kobalta i nikla u krvi odraslih stanovnika grada
Beograda, kao i stepen uticaja individualnih, socioekonomskih faktora i životnih navika na
nivoe ovih metala u krvi. Ispitivanu populaciju je činilo odraslo, zdravo stanovništvo,ukupno
715 muškaraca (72,7%) i 269 žena (27,3%) od 18 do 65 godina starosti, koji su bili
dobrovoljni davaoci krvi. Za analizu je korišćena krv sakupljana u vakutejnere sa heparinom.
Analizirano je 984 uzoraka. Koncentracija metala je određena metodom masene
spektrometrije sa induktivno spregnutom plazmom (7700x, Agilent, USA), sa oktopol
reaktivnim sistemom i „micro‐flow“ raspršivačem. Prosečna starost ispitanika iznosila je
37,210,8 godina. Referentne vrednosti ispitivanih metala u krvi, prikazane kao 95. percentil
su 0,95 µg/L, 0,62 µg/L i 1,46 µg/L za hrom, kobalt i nikl, redom, su u dobroj korelaciji sa
vrednostima dobijenim u biomonitoring studijama sprovedenim u Evropi. Istraživanje
uticaja individualnih faktora je pokazalo da je hrom izmeren u značajno nižim
koncentracijama kod stanovništva srpske nacionalnosti, da su nivoi kobalta u krvi žena
značajno viši i da se nivoi kobalta i nikla povećavaju sa starenjem kod oba pola. Obrazovanje
i ekonomski status, pušenje cigareta i bavljenje sportom ne utiču statistički značajno na
nivoe ovih metala u krvi.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Determination of chromium, cobalt and nickel in the blood of the adult population living in Belgrade, Određivanje nivoa hroma, kobalta i nikla u krvi odraslog stanovništva na teritoriji Beograda",
volume = "72",
number = "4 suplement",
pages = "S603-S604",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4639"
}
