TY  - JOUR
AU  - Simachew, Yonas Mulat
AU  - Antonić, Tamara
AU  - Gojković, Tamara
AU  - Vladimirov, Sandra
AU  - Mihajlović, Marija
AU  - Vujčić, Sanja
AU  - Miloševski-Lomić, Gordana
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Peco-Antić, Amira
AU  - Paripović, Dušan
AU  - Stefanović, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4195
AB  - Introduction  The aim of this study was to investigate lipoprotein particle distributions and the likelihood of achieving cholesterol homeostasis in the remission phase of nephrotic syndrome (NS) in paediatric patients. We hypothesized that lipoprotein particle distributions moved toward less atherogenic profile and that cholesterol homeostasis was achieved. Materials and methods  Thirty-three children, 2 to 9 years old with NS were recruited. Blood sampling took place both in the acute phase and during remission. Serum low-density lipoprotein particles (LDL) and high-density lipoprotein particles (HDL) were separated using non-denaturing polyacrylamide gradient gel (3-31%) electrophoresis. Serum non-cholesterols sterols (NCSs), desmosterol, lathosterol, 7-dehydrocholesterol (7-DHC), campesterol and β-sitosterol were measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Results  All patients had desirable serum HDL cholesterol concentrations during remission. The dominant lipoprotein diameters and LDL subclass distribution did not change significantly during follow-up. In contrast, HDL lipoprotein particle distribution shifted towards larger particles. The absolute concentration of desmosterol was significantly lower during remission (P = 0.023). β-sitosterol concentration markedly increased during remission (P = 0.005). Desmosterol/β-sitosterol (P < 0.001) and 7-DHC/β-sitosterol (P = 0.005) ratios significantly declined during disease remission. Conclusions  Favourable changes in the serum lipid profiles, HDL particle subclass distribution and cholesterol metabolism in paediatric patients with NS during remission took place. For the first time, we found that cholesterol homeostasis changed in favour of increased cholesterol absorption during disease remission. Nevertheless, complete cholesterol homeostasis was not achieved during disease remission.
PB  - Croatian Society of Medical Biochemistry and Laboratory Medicine
T2  - Biochemia Medica
T1  - Lipoproteins and cholesterol homeostasis in paediatric nephrotic syndrome patients
VL  - 32
IS  - 2
DO  - 10.11613/BM.2022.020706
ER  - 

@article{
author = "Simachew, Yonas Mulat and Antonić, Tamara and Gojković, Tamara and Vladimirov, Sandra and Mihajlović, Marija and Vujčić, Sanja and Miloševski-Lomić, Gordana and Vekić, Jelena and Zeljković, Aleksandra and Spasojević-Kalimanovska, Vesna and Peco-Antić, Amira and Paripović, Dušan and Stefanović, Aleksandra",
year = "2022",
abstract = "Introduction  The aim of this study was to investigate lipoprotein particle distributions and the likelihood of achieving cholesterol homeostasis in the remission phase of nephrotic syndrome (NS) in paediatric patients. We hypothesized that lipoprotein particle distributions moved toward less atherogenic profile and that cholesterol homeostasis was achieved. Materials and methods  Thirty-three children, 2 to 9 years old with NS were recruited. Blood sampling took place both in the acute phase and during remission. Serum low-density lipoprotein particles (LDL) and high-density lipoprotein particles (HDL) were separated using non-denaturing polyacrylamide gradient gel (3-31%) electrophoresis. Serum non-cholesterols sterols (NCSs), desmosterol, lathosterol, 7-dehydrocholesterol (7-DHC), campesterol and β-sitosterol were measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Results  All patients had desirable serum HDL cholesterol concentrations during remission. The dominant lipoprotein diameters and LDL subclass distribution did not change significantly during follow-up. In contrast, HDL lipoprotein particle distribution shifted towards larger particles. The absolute concentration of desmosterol was significantly lower during remission (P = 0.023). β-sitosterol concentration markedly increased during remission (P = 0.005). Desmosterol/β-sitosterol (P < 0.001) and 7-DHC/β-sitosterol (P = 0.005) ratios significantly declined during disease remission. Conclusions  Favourable changes in the serum lipid profiles, HDL particle subclass distribution and cholesterol metabolism in paediatric patients with NS during remission took place. For the first time, we found that cholesterol homeostasis changed in favour of increased cholesterol absorption during disease remission. Nevertheless, complete cholesterol homeostasis was not achieved during disease remission.",
publisher = "Croatian Society of Medical Biochemistry and Laboratory Medicine",
journal = "Biochemia Medica",
title = "Lipoproteins and cholesterol homeostasis in paediatric nephrotic syndrome patients",
volume = "32",
number = "2",
doi = "10.11613/BM.2022.020706"
}

Simachew, Y. M., Antonić, T., Gojković, T., Vladimirov, S., Mihajlović, M., Vujčić, S., Miloševski-Lomić, G., Vekić, J., Zeljković, A., Spasojević-Kalimanovska, V., Peco-Antić, A., Paripović, D.,& Stefanović, A.. (2022). Lipoproteins and cholesterol homeostasis in paediatric nephrotic syndrome patients. in Biochemia Medica
Croatian Society of Medical Biochemistry and Laboratory Medicine., 32(2).
https://doi.org/10.11613/BM.2022.020706

Simachew YM, Antonić T, Gojković T, Vladimirov S, Mihajlović M, Vujčić S, Miloševski-Lomić G, Vekić J, Zeljković A, Spasojević-Kalimanovska V, Peco-Antić A, Paripović D, Stefanović A. Lipoproteins and cholesterol homeostasis in paediatric nephrotic syndrome patients. in Biochemia Medica. 2022;32(2).
doi:10.11613/BM.2022.020706 .

Simachew, Yonas Mulat, Antonić, Tamara, Gojković, Tamara, Vladimirov, Sandra, Mihajlović, Marija, Vujčić, Sanja, Miloševski-Lomić, Gordana, Vekić, Jelena, Zeljković, Aleksandra, Spasojević-Kalimanovska, Vesna, Peco-Antić, Amira, Paripović, Dušan, Stefanović, Aleksandra, "Lipoproteins and cholesterol homeostasis in paediatric nephrotic syndrome patients" in Biochemia Medica, 32, no. 2 (2022),
https://doi.org/10.11613/BM.2022.020706 . .

TY  - JOUR
AU  - Paripović, Dušan
AU  - Kotur-Stevuljević, Jelena
AU  - Vukašinović, Aleksandra
AU  - Ilisić, Tamara
AU  - Miloševski-Lomić, Gordana
AU  - Peco-Antić, Amira
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3144
AB  - Oxidative stress seems to be an important link between obesity and cardiovascular disease. The aim of our study was to assess oxidative stress in obese patients stratified according to ambulatory blood pressure status and to determine independent predictors of abnormal left ventricular geometry.A cross-sectional study was conducted. A total of 113 obese participants referred for 24-h ambulatory blood pressure monitoring (ABPM) aged 9-19 years, and 29 healthy controls were enrolled. In addition to anthropometric and biochemical measurements, such as fasting serum levels of glucose, insulin, lipid profile, and oxidative biomarkers, ABPM and echocardiography were performed.According to ABPM results, obese subjects were split in two groups: 57 hypertensive and 56 normotensive. Both hypertensive and normotensive obese participants had higher levels of oxidative stress parameters (pro-oxidative/antioxidative balance and total oxidant status) compared with control group. Levels of superoxide anion (O-2(-)) and sulfhydryl groups were higher in obese hypertensive participants as compared to obese normotensive and control groups. Abnormal left ventricular geometry among obese participants was independently associated with O-2(-) (p = .006) and body mass index z score (p = .020), with no significant impact of gender, while age and systolic blood pressure exhibited interaction term for the outcome.The independent effect of oxidative mechanisms on left ventricular geometry appears to start in childhood. Oxidative stress occurs in obese adolescents prior to the development of sustained hypertension.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Scandinavian Journal of Clinical and Laboratory Investigation
T1  - The influence of oxidative stress on cardiac remodeling in obese adolescents
VL  - 78
IS  - 7-8
SP  - 595
EP  - 600
DO  - 10.1080/00365513.2018.1528504
ER  - 

@article{
author = "Paripović, Dušan and Kotur-Stevuljević, Jelena and Vukašinović, Aleksandra and Ilisić, Tamara and Miloševski-Lomić, Gordana and Peco-Antić, Amira",
year = "2018",
abstract = "Oxidative stress seems to be an important link between obesity and cardiovascular disease. The aim of our study was to assess oxidative stress in obese patients stratified according to ambulatory blood pressure status and to determine independent predictors of abnormal left ventricular geometry.A cross-sectional study was conducted. A total of 113 obese participants referred for 24-h ambulatory blood pressure monitoring (ABPM) aged 9-19 years, and 29 healthy controls were enrolled. In addition to anthropometric and biochemical measurements, such as fasting serum levels of glucose, insulin, lipid profile, and oxidative biomarkers, ABPM and echocardiography were performed.According to ABPM results, obese subjects were split in two groups: 57 hypertensive and 56 normotensive. Both hypertensive and normotensive obese participants had higher levels of oxidative stress parameters (pro-oxidative/antioxidative balance and total oxidant status) compared with control group. Levels of superoxide anion (O-2(-)) and sulfhydryl groups were higher in obese hypertensive participants as compared to obese normotensive and control groups. Abnormal left ventricular geometry among obese participants was independently associated with O-2(-) (p = .006) and body mass index z score (p = .020), with no significant impact of gender, while age and systolic blood pressure exhibited interaction term for the outcome.The independent effect of oxidative mechanisms on left ventricular geometry appears to start in childhood. Oxidative stress occurs in obese adolescents prior to the development of sustained hypertension.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
title = "The influence of oxidative stress on cardiac remodeling in obese adolescents",
volume = "78",
number = "7-8",
pages = "595-600",
doi = "10.1080/00365513.2018.1528504"
}

Paripović, D., Kotur-Stevuljević, J., Vukašinović, A., Ilisić, T., Miloševski-Lomić, G.,& Peco-Antić, A.. (2018). The influence of oxidative stress on cardiac remodeling in obese adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation
Taylor & Francis Ltd, Abingdon., 78(7-8), 595-600.
https://doi.org/10.1080/00365513.2018.1528504

Paripović D, Kotur-Stevuljević J, Vukašinović A, Ilisić T, Miloševski-Lomić G, Peco-Antić A. The influence of oxidative stress on cardiac remodeling in obese adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation. 2018;78(7-8):595-600.
doi:10.1080/00365513.2018.1528504 .

Paripović, Dušan, Kotur-Stevuljević, Jelena, Vukašinović, Aleksandra, Ilisić, Tamara, Miloševski-Lomić, Gordana, Peco-Antić, Amira, "The influence of oxidative stress on cardiac remodeling in obese adolescents" in Scandinavian Journal of Clinical and Laboratory Investigation, 78, no. 7-8 (2018):595-600,
https://doi.org/10.1080/00365513.2018.1528504 . .

TY  - JOUR
AU  - Bekhet, Osama H.
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Paripović, Dušan
AU  - Gojković, Tamara
AU  - Janać, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Peco-Antić, Amira
AU  - Miloševski-Lomić, Gordana
AU  - Jelić-Ivanović, Zorana
AU  - Stefanović, Aleksandra
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2845
AB  - N Background/aim: Juvenile obesity is associated with several metabolic abnormalities, one of them being atherogenic dyslipidemia. Suboptimal fetal growth is associated with obesity risk in childhood, but also with increased rate of metabolic diseases in later life. This study investigated associations of neonatal data (Apgar score, birth weight and birth length) with low-density lipoprotein and high-density lipoprotein (LDL and HDL) subclasses in a group of obese children, as well as a possible impact of breastfeeding duration on obesity-associated lipoprotein subclasses distributions. Materials and methods: We included 42 obese children, aged 14.2 +/- 2.1 years. LDL and HDL subfractions were separated by gradient gel electrophoresis and biochemical parameters were assessed by routine methods. Results: Compared with obese children with Apgar >= 9, the group with Apgar  lt  9 had significantly higher percentages of small, dense LDL particles (P  lt  0.05), due to reduced LDL I (P  lt  0.01) and increased LDL III subclasses (P  lt  0.05). Birth weight was positively associated with the proportions of LDL I particles (P  lt  0.001), whereas birth height positively correlated with the amount of HDL 2b subclasses (P  lt  0.05). The group of never or less than 3 months breastfed children had significantly smaller LDL size (P  lt  0.01) and lower proportion of HDL 2a particles (P  lt  0.05) than their >= 3 months breastfed peers. Conclusion: The results showed significant associations of neonatal characteristics with LDL and HDL particle distributions in obese children. In addition, our results point toward positive aspects of longer breastfeeding duration on lipoprotein particle distributions in obese children.
PB  - Tubitak Scientific & Technical Research Council Turkey, Ankara
T2  - Upsala Journal of Medical Sciences
T1  - Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity
VL  - 47
IS  - 6
SP  - 1804
EP  - 1812
DO  - 10.3906/sag-1702-164
ER  - 

@article{
author = "Bekhet, Osama H. and Vekić, Jelena and Zeljković, Aleksandra and Paripović, Dušan and Gojković, Tamara and Janać, Jelena and Spasojević-Kalimanovska, Vesna and Peco-Antić, Amira and Miloševski-Lomić, Gordana and Jelić-Ivanović, Zorana and Stefanović, Aleksandra",
year = "2017",
abstract = "N Background/aim: Juvenile obesity is associated with several metabolic abnormalities, one of them being atherogenic dyslipidemia. Suboptimal fetal growth is associated with obesity risk in childhood, but also with increased rate of metabolic diseases in later life. This study investigated associations of neonatal data (Apgar score, birth weight and birth length) with low-density lipoprotein and high-density lipoprotein (LDL and HDL) subclasses in a group of obese children, as well as a possible impact of breastfeeding duration on obesity-associated lipoprotein subclasses distributions. Materials and methods: We included 42 obese children, aged 14.2 +/- 2.1 years. LDL and HDL subfractions were separated by gradient gel electrophoresis and biochemical parameters were assessed by routine methods. Results: Compared with obese children with Apgar >= 9, the group with Apgar  lt  9 had significantly higher percentages of small, dense LDL particles (P  lt  0.05), due to reduced LDL I (P  lt  0.01) and increased LDL III subclasses (P  lt  0.05). Birth weight was positively associated with the proportions of LDL I particles (P  lt  0.001), whereas birth height positively correlated with the amount of HDL 2b subclasses (P  lt  0.05). The group of never or less than 3 months breastfed children had significantly smaller LDL size (P  lt  0.01) and lower proportion of HDL 2a particles (P  lt  0.05) than their >= 3 months breastfed peers. Conclusion: The results showed significant associations of neonatal characteristics with LDL and HDL particle distributions in obese children. In addition, our results point toward positive aspects of longer breastfeeding duration on lipoprotein particle distributions in obese children.",
publisher = "Tubitak Scientific & Technical Research Council Turkey, Ankara",
journal = "Upsala Journal of Medical Sciences",
title = "Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity",
volume = "47",
number = "6",
pages = "1804-1812",
doi = "10.3906/sag-1702-164"
}

Bekhet, O. H., Vekić, J., Zeljković, A., Paripović, D., Gojković, T., Janać, J., Spasojević-Kalimanovska, V., Peco-Antić, A., Miloševski-Lomić, G., Jelić-Ivanović, Z.,& Stefanović, A.. (2017). Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity. in Upsala Journal of Medical Sciences
Tubitak Scientific & Technical Research Council Turkey, Ankara., 47(6), 1804-1812.
https://doi.org/10.3906/sag-1702-164

Bekhet OH, Vekić J, Zeljković A, Paripović D, Gojković T, Janać J, Spasojević-Kalimanovska V, Peco-Antić A, Miloševski-Lomić G, Jelić-Ivanović Z, Stefanović A. Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity. in Upsala Journal of Medical Sciences. 2017;47(6):1804-1812.
doi:10.3906/sag-1702-164 .

Bekhet, Osama H., Vekić, Jelena, Zeljković, Aleksandra, Paripović, Dušan, Gojković, Tamara, Janać, Jelena, Spasojević-Kalimanovska, Vesna, Peco-Antić, Amira, Miloševski-Lomić, Gordana, Jelić-Ivanović, Zorana, Stefanović, Aleksandra, "Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity" in Upsala Journal of Medical Sciences, 47, no. 6 (2017):1804-1812,
https://doi.org/10.3906/sag-1702-164 . .

TY  - JOUR
AU  - Ristovski-Kornić, Danijela
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Zeljković, Aleksandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Vekić, Jelena
AU  - Miljković, Milica
AU  - Paripović, Dušan
AU  - Peco-Antić, Amira
AU  - Jelić-Ivanović, Zorana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2956
AB  - Background: The aim of this study was to explore oxidative stress status, especially the enzyme myeloperoxidase in children with end-stage renal disease. Also, we investigated possible associations between the atherogenic index of plasma and these parameters. Methods: Lipid status parameters, oxidative stress status parameters, and myeloperoxidase concentration were measured in the sera of 20 children in the last stage of chronic renal disease (ESRD) and 35 healthy children of matching age and sex. The Atherogenic Index of Plasma (AIP) was calculated according to the appropriate equation. Results: We did not find any significant differences in myeloperoxidase concentrations between the investigated groups (p = 0.394). Oxidative stress parameters were, however, significantly higher in the patient group (p  lt  0.001), as well as the atherogenic index of plasma (p  lt  0.001). Myelo per oxidase concentration and advanced oxidation protein product (AOPP) concentration were independently associated with increased AIP in the patient group (p  lt  0.05). Conclusions: Changes in AIP in children with ERSD are associated with the oxidative stress status and myeloper oxidase concentration.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease
VL  - 36
IS  - 1
SP  - 23
EP  - 31
DO  - 10.1515/jomb-2016-0027
ER  - 

@article{
author = "Ristovski-Kornić, Danijela and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Zeljković, Aleksandra and Spasojević-Kalimanovska, Vesna and Vekić, Jelena and Miljković, Milica and Paripović, Dušan and Peco-Antić, Amira and Jelić-Ivanović, Zorana",
year = "2017",
abstract = "Background: The aim of this study was to explore oxidative stress status, especially the enzyme myeloperoxidase in children with end-stage renal disease. Also, we investigated possible associations between the atherogenic index of plasma and these parameters. Methods: Lipid status parameters, oxidative stress status parameters, and myeloperoxidase concentration were measured in the sera of 20 children in the last stage of chronic renal disease (ESRD) and 35 healthy children of matching age and sex. The Atherogenic Index of Plasma (AIP) was calculated according to the appropriate equation. Results: We did not find any significant differences in myeloperoxidase concentrations between the investigated groups (p = 0.394). Oxidative stress parameters were, however, significantly higher in the patient group (p  lt  0.001), as well as the atherogenic index of plasma (p  lt  0.001). Myelo per oxidase concentration and advanced oxidation protein product (AOPP) concentration were independently associated with increased AIP in the patient group (p  lt  0.05). Conclusions: Changes in AIP in children with ERSD are associated with the oxidative stress status and myeloper oxidase concentration.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease",
volume = "36",
number = "1",
pages = "23-31",
doi = "10.1515/jomb-2016-0027"
}

Ristovski-Kornić, D., Stefanović, A., Kotur-Stevuljević, J., Zeljković, A., Spasojević-Kalimanovska, V., Vekić, J., Miljković, M., Paripović, D., Peco-Antić, A.,& Jelić-Ivanović, Z.. (2017). Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 36(1), 23-31.
https://doi.org/10.1515/jomb-2016-0027

Ristovski-Kornić D, Stefanović A, Kotur-Stevuljević J, Zeljković A, Spasojević-Kalimanovska V, Vekić J, Miljković M, Paripović D, Peco-Antić A, Jelić-Ivanović Z. Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease. in Journal of Medical Biochemistry. 2017;36(1):23-31.
doi:10.1515/jomb-2016-0027 .

Ristovski-Kornić, Danijela, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Zeljković, Aleksandra, Spasojević-Kalimanovska, Vesna, Vekić, Jelena, Miljković, Milica, Paripović, Dušan, Peco-Antić, Amira, Jelić-Ivanović, Zorana, "Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease" in Journal of Medical Biochemistry, 36, no. 1 (2017):23-31,
https://doi.org/10.1515/jomb-2016-0027 . .

TY  - JOUR
AU  - Stefanović, Aleksandra
AU  - Ristovski-Kornić, Danijela
AU  - Kotur-Stevuljević, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Vekić, Jelena
AU  - Miljković, Milica
AU  - Paripović, Dušan
AU  - Peco-Antić, Amira
AU  - Jelić-Ivanović, Zorana
AU  - Zeljković, Aleksandra
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2815
AB  - Background: Unfavorable lipid profile presents one of most important risk factor for cardiovascular disease in renal pathology. Myeloperoxidase (MPO) as enzyme which oxidizes lipoproteins and paraoxonase1 (PON1) as anti-oxidative enzyme have been involved in pathogenesis of cardiovascular disease. In the present study we sought to assess oxidative stress status, lipoprotein subclasses distribution as well as functionality of high density lipoprotein (HDL) trough MPO/PON1 ratio in children with chronic kidney disease (CKD) and children after renal transplantation. Methods: PON1 activity and oxidative stress parameters were measured spectrophotometrically, while MPO concentration was determined using immunoassay. Separation of lipoprotein subclasses was performed by vertical gradient gel electrophoresis in 19 children with different stage of CKD and 19 post-transplantation patients (PT). Results: CKD patients had increased MPO/PON1 ratio and higher prevalence of smaller HDL subclasses when compared to PT subjects. Also, there was a significant positive correlation between MPO level and MPO/PON1 ratio with relative proportion of smaller HDL subclasses. Conclusions: Children with CKD have impaired HDL distribution that is improved after kidney transplantation. Since that measurement of HDL distribution and functionality arenot routinely available, MPO/PON1 ratio may be useful marker that could provide necessary information.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Alterations of HDL Particles in Children with End-Stage Renal Disease
VL  - 36
IS  - 4
SP  - 358
EP  - 365
DO  - 10.1515/jomb-2017-0019
ER  - 

@article{
author = "Stefanović, Aleksandra and Ristovski-Kornić, Danijela and Kotur-Stevuljević, Jelena and Spasojević-Kalimanovska, Vesna and Vekić, Jelena and Miljković, Milica and Paripović, Dušan and Peco-Antić, Amira and Jelić-Ivanović, Zorana and Zeljković, Aleksandra",
year = "2017",
abstract = "Background: Unfavorable lipid profile presents one of most important risk factor for cardiovascular disease in renal pathology. Myeloperoxidase (MPO) as enzyme which oxidizes lipoproteins and paraoxonase1 (PON1) as anti-oxidative enzyme have been involved in pathogenesis of cardiovascular disease. In the present study we sought to assess oxidative stress status, lipoprotein subclasses distribution as well as functionality of high density lipoprotein (HDL) trough MPO/PON1 ratio in children with chronic kidney disease (CKD) and children after renal transplantation. Methods: PON1 activity and oxidative stress parameters were measured spectrophotometrically, while MPO concentration was determined using immunoassay. Separation of lipoprotein subclasses was performed by vertical gradient gel electrophoresis in 19 children with different stage of CKD and 19 post-transplantation patients (PT). Results: CKD patients had increased MPO/PON1 ratio and higher prevalence of smaller HDL subclasses when compared to PT subjects. Also, there was a significant positive correlation between MPO level and MPO/PON1 ratio with relative proportion of smaller HDL subclasses. Conclusions: Children with CKD have impaired HDL distribution that is improved after kidney transplantation. Since that measurement of HDL distribution and functionality arenot routinely available, MPO/PON1 ratio may be useful marker that could provide necessary information.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Alterations of HDL Particles in Children with End-Stage Renal Disease",
volume = "36",
number = "4",
pages = "358-365",
doi = "10.1515/jomb-2017-0019"
}

Stefanović, A., Ristovski-Kornić, D., Kotur-Stevuljević, J., Spasojević-Kalimanovska, V., Vekić, J., Miljković, M., Paripović, D., Peco-Antić, A., Jelić-Ivanović, Z.,& Zeljković, A.. (2017). Alterations of HDL Particles in Children with End-Stage Renal Disease. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 36(4), 358-365.
https://doi.org/10.1515/jomb-2017-0019

Stefanović A, Ristovski-Kornić D, Kotur-Stevuljević J, Spasojević-Kalimanovska V, Vekić J, Miljković M, Paripović D, Peco-Antić A, Jelić-Ivanović Z, Zeljković A. Alterations of HDL Particles in Children with End-Stage Renal Disease. in Journal of Medical Biochemistry. 2017;36(4):358-365.
doi:10.1515/jomb-2017-0019 .

Stefanović, Aleksandra, Ristovski-Kornić, Danijela, Kotur-Stevuljević, Jelena, Spasojević-Kalimanovska, Vesna, Vekić, Jelena, Miljković, Milica, Paripović, Dušan, Peco-Antić, Amira, Jelić-Ivanović, Zorana, Zeljković, Aleksandra, "Alterations of HDL Particles in Children with End-Stage Renal Disease" in Journal of Medical Biochemistry, 36, no. 4 (2017):358-365,
https://doi.org/10.1515/jomb-2017-0019 . .

TY  - JOUR
AU  - Ivanišević, Jasmina
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Miljković, Milica
AU  - Jelić-Ivanović, Zorana
AU  - Pejović, Biljana
AU  - Peco-Antić, Amira
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2998
AB  - Objectives: Acute kidney injury (AKI) is defined as a decrease in glomerular filtration rate with an increase in serum creatinine (sCr). Perinatal asphyxia (PNA) may be etiological factor for AKI with oxidative stress also implicated. Paraoxonase 1 (PON1) activity has been reported to be decreased in renal disease. The aim of our study was to evaluate paraoxonase 1 (PON1) activity and oxidative stress during the first hours and first days of life and to determine if these parameters could discriminate neonates having AKI from those who do not. Methods: Serum samples at different time points after birth were obtained from 64 preterm newborns with PNA (45 defined as having AKI, 19 as non-AKI). Clinical markers, sCr, total oxidant status (TOS), total antioxidant status (TAS) and PON1 activity were measured. Results: The AKI group had more newborns with hypoxic ischemic encephalopathy, significantly higher serum creatinine (sCr) at 3 and 7d, total antioxidant status (TAS) at 7d; decreased PON1 at 4h, 6h and 7d than the non-AKI group. Within the AKI group, significant positive correlations were found between PON1 activity at 2h and TAS at 2h, PON1 activity at 4h and base deficit (BD); whereas negative correlations between PON1 activity at 2h and AsCr (at 24h and at 3d), PON1 activity at 7d and AsCr (at 24h and 3d). Oxidative stress status parameters indicated excellent discriminative potential at 4h, 6h and 7d. Conclusions: AKI neonates were characterised by a marked decrease in PON1 activity. PON1 activity may be an important factor for discrimination of newborns having AKI from those that do not.
PB  - Elsevier Ireland Ltd, Clare
T2  - Chemico-Biological Interactions
T1  - Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates
VL  - 272
SP  - 47
EP  - 52
DO  - 10.1016/j.cbi.2017.04.014
ER  - 

@article{
author = "Ivanišević, Jasmina and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Miljković, Milica and Jelić-Ivanović, Zorana and Pejović, Biljana and Peco-Antić, Amira",
year = "2017",
abstract = "Objectives: Acute kidney injury (AKI) is defined as a decrease in glomerular filtration rate with an increase in serum creatinine (sCr). Perinatal asphyxia (PNA) may be etiological factor for AKI with oxidative stress also implicated. Paraoxonase 1 (PON1) activity has been reported to be decreased in renal disease. The aim of our study was to evaluate paraoxonase 1 (PON1) activity and oxidative stress during the first hours and first days of life and to determine if these parameters could discriminate neonates having AKI from those who do not. Methods: Serum samples at different time points after birth were obtained from 64 preterm newborns with PNA (45 defined as having AKI, 19 as non-AKI). Clinical markers, sCr, total oxidant status (TOS), total antioxidant status (TAS) and PON1 activity were measured. Results: The AKI group had more newborns with hypoxic ischemic encephalopathy, significantly higher serum creatinine (sCr) at 3 and 7d, total antioxidant status (TAS) at 7d; decreased PON1 at 4h, 6h and 7d than the non-AKI group. Within the AKI group, significant positive correlations were found between PON1 activity at 2h and TAS at 2h, PON1 activity at 4h and base deficit (BD); whereas negative correlations between PON1 activity at 2h and AsCr (at 24h and at 3d), PON1 activity at 7d and AsCr (at 24h and 3d). Oxidative stress status parameters indicated excellent discriminative potential at 4h, 6h and 7d. Conclusions: AKI neonates were characterised by a marked decrease in PON1 activity. PON1 activity may be an important factor for discrimination of newborns having AKI from those that do not.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Chemico-Biological Interactions",
title = "Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates",
volume = "272",
pages = "47-52",
doi = "10.1016/j.cbi.2017.04.014"
}

Ivanišević, J., Kotur-Stevuljević, J., Stefanović, A., Miljković, M., Jelić-Ivanović, Z., Pejović, B.,& Peco-Antić, A.. (2017). Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates. in Chemico-Biological Interactions
Elsevier Ireland Ltd, Clare., 272, 47-52.
https://doi.org/10.1016/j.cbi.2017.04.014

Ivanišević J, Kotur-Stevuljević J, Stefanović A, Miljković M, Jelić-Ivanović Z, Pejović B, Peco-Antić A. Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates. in Chemico-Biological Interactions. 2017;272:47-52.
doi:10.1016/j.cbi.2017.04.014 .

Ivanišević, Jasmina, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Miljković, Milica, Jelić-Ivanović, Zorana, Pejović, Biljana, Peco-Antić, Amira, "Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates" in Chemico-Biological Interactions, 272 (2017):47-52,
https://doi.org/10.1016/j.cbi.2017.04.014 . .

TY  - JOUR
AU  - Bekhet, Osama H.
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Paripović, Dušan
AU  - Janać, Jelena
AU  - Joksić, Jelena
AU  - Gojković, Tamara
AU  - Spasojević-Kalimanovska, Vesna
AU  - Peco-Antić, Amira
AU  - Miloševski-Lomić, Gordana
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2727
AB  - Background: Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.Methods: A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.Results: Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese children. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p= 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles ( =-0.423; p= 0.025) in the group with hypertension.Conclusions: The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Scandinavian Journal of Clinical and Laboratory Investigation
T1  - Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents
VL  - 76
IS  - 6
SP  - 472
EP  - 478
DO  - 10.1080/00365513.2016.1201849
ER  - 

@article{
author = "Bekhet, Osama H. and Zeljković, Aleksandra and Vekić, Jelena and Paripović, Dušan and Janać, Jelena and Joksić, Jelena and Gojković, Tamara and Spasojević-Kalimanovska, Vesna and Peco-Antić, Amira and Miloševski-Lomić, Gordana and Jelić-Ivanović, Zorana",
year = "2016",
abstract = "Background: Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.Methods: A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.Results: Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese children. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p= 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles ( =-0.423; p= 0.025) in the group with hypertension.Conclusions: The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
title = "Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents",
volume = "76",
number = "6",
pages = "472-478",
doi = "10.1080/00365513.2016.1201849"
}

Bekhet, O. H., Zeljković, A., Vekić, J., Paripović, D., Janać, J., Joksić, J., Gojković, T., Spasojević-Kalimanovska, V., Peco-Antić, A., Miloševski-Lomić, G.,& Jelić-Ivanović, Z.. (2016). Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation
Taylor & Francis Ltd, Abingdon., 76(6), 472-478.
https://doi.org/10.1080/00365513.2016.1201849

Bekhet OH, Zeljković A, Vekić J, Paripović D, Janać J, Joksić J, Gojković T, Spasojević-Kalimanovska V, Peco-Antić A, Miloševski-Lomić G, Jelić-Ivanović Z. Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation. 2016;76(6):472-478.
doi:10.1080/00365513.2016.1201849 .

Bekhet, Osama H., Zeljković, Aleksandra, Vekić, Jelena, Paripović, Dušan, Janać, Jelena, Joksić, Jelena, Gojković, Tamara, Spasojević-Kalimanovska, Vesna, Peco-Antić, Amira, Miloševski-Lomić, Gordana, Jelić-Ivanović, Zorana, "Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents" in Scandinavian Journal of Clinical and Laboratory Investigation, 76, no. 6 (2016):472-478,
https://doi.org/10.1080/00365513.2016.1201849 . .

TY  - JOUR
AU  - Pejović, Biljana
AU  - Erić-Marinković, Jelena
AU  - Pejović, Marija
AU  - Kotur-Stevuljević, Jelena
AU  - Peco-Antić, Amira
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2329
AB  - Introduction: Acute kidney injury (AKI) is common in neonatal intensive care units (NICU). In recent years, every effort is made for early detection of AKI. Our hypothesis was that serum neutrophil gelatinase-associated lipocalin (sNGAL) may be a reliable screening test for early diagnosis of AKI in premature neonates after perinatal asphyxia. Therefore, our aim was to assess the diagnostic accuracy of sNGAL for AKI in premature asphyxiated neonates. Materials and methods: AKI was defined in the third day of life (DOL 3) as a serum creatinine (sCr) increase >= 26.5 mu mol/L from baseline (the lowest previous sCr). According to the increase of sCr, AKI patients were divided in AKIN1 (sCr increase up to 1.9 baseline) and AKIN2 (sCr increase from 2.0 to 2.9 baseline). sNGAL levels were measured on DOL 1, 3 and 7. Results: AKI was diagnosed in 73 (0.676) of 108 enrolled premature asphyxiated neonates. Sixty one patients (0.836) were classified in AKIN1 and 12 patients (0.164) in AKIN2. sNGAL reached the maximal concentrations on DOL 1 within 4 hours after admission to NICU, being higher in AKI compared with no-AKI group (160.8 +/- 113.1 vs. 87.1 +/- 81.6; P  lt  0.001) as well as in AKIN2 compared with AKIN1 group (222.8 +/- 112.9 vs. 147.8 +/- 109.9; P  lt  0.001). The best areas under the receiver operating characteristic curves (AUC) for prediction of AKI were 0.72 [95% (0.62-0.80) P  lt  0.001] on DOL1 at 2h and 0.72 [95% (0.63-0.80) P  lt  0.001] at 4th hour after admission respectively. The corresponding sNGAL cutoff concentrations were 84.87 ng/mL (sensitivity 69.0% and specificity 71.9%) and 89.43 ng/mL (sensitivity 65.7% and specificity 74.3%). Conclusions: In premature asphyxiated neonates sNGAL measured within the first 4 hours of DOL 1 is predictive of the occurrence and severity of AKI. Therefore, plasma levels of NGAL may be used for early diagnosis of AKI in these patients.
PB  - Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb
T2  - Biochemia Medica
T1  - Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) - sensitivity and specificity of a potential new biomarker
VL  - 25
IS  - 3
SP  - 450
EP  - 459
DO  - 10.11613/BM.2015.046
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2329
ER  - 

@article{
author = "Pejović, Biljana and Erić-Marinković, Jelena and Pejović, Marija and Kotur-Stevuljević, Jelena and Peco-Antić, Amira",
year = "2015",
abstract = "Introduction: Acute kidney injury (AKI) is common in neonatal intensive care units (NICU). In recent years, every effort is made for early detection of AKI. Our hypothesis was that serum neutrophil gelatinase-associated lipocalin (sNGAL) may be a reliable screening test for early diagnosis of AKI in premature neonates after perinatal asphyxia. Therefore, our aim was to assess the diagnostic accuracy of sNGAL for AKI in premature asphyxiated neonates. Materials and methods: AKI was defined in the third day of life (DOL 3) as a serum creatinine (sCr) increase >= 26.5 mu mol/L from baseline (the lowest previous sCr). According to the increase of sCr, AKI patients were divided in AKIN1 (sCr increase up to 1.9 baseline) and AKIN2 (sCr increase from 2.0 to 2.9 baseline). sNGAL levels were measured on DOL 1, 3 and 7. Results: AKI was diagnosed in 73 (0.676) of 108 enrolled premature asphyxiated neonates. Sixty one patients (0.836) were classified in AKIN1 and 12 patients (0.164) in AKIN2. sNGAL reached the maximal concentrations on DOL 1 within 4 hours after admission to NICU, being higher in AKI compared with no-AKI group (160.8 +/- 113.1 vs. 87.1 +/- 81.6; P  lt  0.001) as well as in AKIN2 compared with AKIN1 group (222.8 +/- 112.9 vs. 147.8 +/- 109.9; P  lt  0.001). The best areas under the receiver operating characteristic curves (AUC) for prediction of AKI were 0.72 [95% (0.62-0.80) P  lt  0.001] on DOL1 at 2h and 0.72 [95% (0.63-0.80) P  lt  0.001] at 4th hour after admission respectively. The corresponding sNGAL cutoff concentrations were 84.87 ng/mL (sensitivity 69.0% and specificity 71.9%) and 89.43 ng/mL (sensitivity 65.7% and specificity 74.3%). Conclusions: In premature asphyxiated neonates sNGAL measured within the first 4 hours of DOL 1 is predictive of the occurrence and severity of AKI. Therefore, plasma levels of NGAL may be used for early diagnosis of AKI in these patients.",
publisher = "Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb",
journal = "Biochemia Medica",
title = "Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) - sensitivity and specificity of a potential new biomarker",
volume = "25",
number = "3",
pages = "450-459",
doi = "10.11613/BM.2015.046",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2329"
}

Pejović, B., Erić-Marinković, J., Pejović, M., Kotur-Stevuljević, J.,& Peco-Antić, A.. (2015). Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) - sensitivity and specificity of a potential new biomarker. in Biochemia Medica
Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb., 25(3), 450-459.
https://doi.org/10.11613/BM.2015.046
https://hdl.handle.net/21.15107/rcub_farfar_2329

Pejović B, Erić-Marinković J, Pejović M, Kotur-Stevuljević J, Peco-Antić A. Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) - sensitivity and specificity of a potential new biomarker. in Biochemia Medica. 2015;25(3):450-459.
doi:10.11613/BM.2015.046
https://hdl.handle.net/21.15107/rcub_farfar_2329 .

Pejović, Biljana, Erić-Marinković, Jelena, Pejović, Marija, Kotur-Stevuljević, Jelena, Peco-Antić, Amira, "Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) - sensitivity and specificity of a potential new biomarker" in Biochemia Medica, 25, no. 3 (2015):450-459,
https://doi.org/10.11613/BM.2015.046 .,
https://hdl.handle.net/21.15107/rcub_farfar_2329 .

TY  - JOUR
AU  - Petrović, Stanislava
AU  - Bogavac-Stanojević, Nataša
AU  - Lakić, Dragana
AU  - Peco-Antić, Amira
AU  - Vulicević, Irena
AU  - Ivanišević, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2467
AB  - Introduction: Acute kidney injury (AKI) is significant problem in children with congenital heart disease (CHD) who undergo cardiac surgery. The economic impact of a biomarker-based diagnostic strategy for AKI in pediatric populations undergoing CHD surgery is unknown. The aim of this study was to perform the cost effectiveness analysis of using serum cystatin C (sCysC), urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine liver fatty acid-binding protein (uL-FABP) for the diagnosis of AKI in children after cardiac surgery compared with current diagnostic method (monitoring of serum creatinine (sCr) level). Materials and methods: We developed a decision analytical model to estimate incremental cost-effectiveness of different biomarker-based diagnostic strategies compared to current diagnostic strategy. The Markov model was created to compare the lifetime cost associated with using of sCysC, uNGAL, uL-FABP with monitoring of sCr level for the diagnosis of AKI. The utility measurement included in the analysis was quality-adjusted life years (QALY). The results of the analysis are presented as the incremental cost-effectiveness ratio (ICER). Results: Analysed biomarker-based diagnostic strategies for AKI were cost-effective compared to current diagnostic method. However, uNGAL and sCys C strategies yielded higher costs and lower effectiveness compared to uL-FABP strategy. uL-FABP added 1.43 QALY compared to current diagnostic method at an additional cost of $8521.87 per patient. Therefore, ICER for uL-FABP compared to sCr was $5959.35/QALY. Conclusions: Our results suggest that the use of uL-FABP would represent cost effective strategy for early diagnosis of AKI in children after cardiac surgery.
PB  - Croatian Soc Medical Biochemists, Zagreb
T2  - Biochemia Medica
T1  - Cost-effectiveness analysis of acute kidney injury biomarkers in pediatric cardiac surgery
VL  - 25
IS  - 2
SP  - 262
EP  - 271
DO  - 10.11613/BM.2015.027
ER  - 

@article{
author = "Petrović, Stanislava and Bogavac-Stanojević, Nataša and Lakić, Dragana and Peco-Antić, Amira and Vulicević, Irena and Ivanišević, Ivana and Kotur-Stevuljević, Jelena and Jelić-Ivanović, Zorana",
year = "2015",
abstract = "Introduction: Acute kidney injury (AKI) is significant problem in children with congenital heart disease (CHD) who undergo cardiac surgery. The economic impact of a biomarker-based diagnostic strategy for AKI in pediatric populations undergoing CHD surgery is unknown. The aim of this study was to perform the cost effectiveness analysis of using serum cystatin C (sCysC), urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine liver fatty acid-binding protein (uL-FABP) for the diagnosis of AKI in children after cardiac surgery compared with current diagnostic method (monitoring of serum creatinine (sCr) level). Materials and methods: We developed a decision analytical model to estimate incremental cost-effectiveness of different biomarker-based diagnostic strategies compared to current diagnostic strategy. The Markov model was created to compare the lifetime cost associated with using of sCysC, uNGAL, uL-FABP with monitoring of sCr level for the diagnosis of AKI. The utility measurement included in the analysis was quality-adjusted life years (QALY). The results of the analysis are presented as the incremental cost-effectiveness ratio (ICER). Results: Analysed biomarker-based diagnostic strategies for AKI were cost-effective compared to current diagnostic method. However, uNGAL and sCys C strategies yielded higher costs and lower effectiveness compared to uL-FABP strategy. uL-FABP added 1.43 QALY compared to current diagnostic method at an additional cost of $8521.87 per patient. Therefore, ICER for uL-FABP compared to sCr was $5959.35/QALY. Conclusions: Our results suggest that the use of uL-FABP would represent cost effective strategy for early diagnosis of AKI in children after cardiac surgery.",
publisher = "Croatian Soc Medical Biochemists, Zagreb",
journal = "Biochemia Medica",
title = "Cost-effectiveness analysis of acute kidney injury biomarkers in pediatric cardiac surgery",
volume = "25",
number = "2",
pages = "262-271",
doi = "10.11613/BM.2015.027"
}

Petrović, S., Bogavac-Stanojević, N., Lakić, D., Peco-Antić, A., Vulicević, I., Ivanišević, I., Kotur-Stevuljević, J.,& Jelić-Ivanović, Z.. (2015). Cost-effectiveness analysis of acute kidney injury biomarkers in pediatric cardiac surgery. in Biochemia Medica
Croatian Soc Medical Biochemists, Zagreb., 25(2), 262-271.
https://doi.org/10.11613/BM.2015.027

Petrović S, Bogavac-Stanojević N, Lakić D, Peco-Antić A, Vulicević I, Ivanišević I, Kotur-Stevuljević J, Jelić-Ivanović Z. Cost-effectiveness analysis of acute kidney injury biomarkers in pediatric cardiac surgery. in Biochemia Medica. 2015;25(2):262-271.
doi:10.11613/BM.2015.027 .

Petrović, Stanislava, Bogavac-Stanojević, Nataša, Lakić, Dragana, Peco-Antić, Amira, Vulicević, Irena, Ivanišević, Ivana, Kotur-Stevuljević, Jelena, Jelić-Ivanović, Zorana, "Cost-effectiveness analysis of acute kidney injury biomarkers in pediatric cardiac surgery" in Biochemia Medica, 25, no. 2 (2015):262-271,
https://doi.org/10.11613/BM.2015.027 . .

TY  - JOUR
AU  - Pavlović, Branko
AU  - Milosavljević, Jovana
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Joksić, Jelena
AU  - Sopić, Miron
AU  - Spasojević-Kalimanovska, Vesna
AU  - Paripović, Dušan
AU  - Peco-Antić, Amira
AU  - Miloševski-Lomić, Gordana
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2514
AB  - Introduction: Childhood obesity is related to cardiovascular diseases and diabetes mellitus type 2 in later life. Resistin, an adipokine primarily secreted by monocytes and tissue macrophages in humans, is considered to be associated with these conditions. The Aim: To examine the correlations between resistin concentration and anthropometric parameters, lipid status, inflammatory markers and parameters of insulin resistance in obese children and adolescents. Material and Methods: The study included 66 patients (40 boys, 26 girls), which underwent anthropometric measuring and laboratory testing (glucose level, total cholesterol, high-density lipoprotein cholesterol (HDL-cholesterol), low-density lipoprotein cholesterol (LDL-cholesterol), triglycerides, uric acid, high-sensitivity C-reactive protein (hsCRP) and glycosylated hemoglobin (HbA1c). Insulin resistance was estimated with HOMA-IR (homeostasis model assessment of insulin resistance). Results: We determined that 63.3% of our patients had dyslipidemia, while hsCRP and uric acid levels suggested an ongoing inflammation. We established that there was a correlation between resistin concentration and waist to hip ratio (WHR) (r=0.294, p lt 0.05), as well as between resistin concentration and HOMA-IR (r=0.293, p lt 0.05). Also, uric acid levels correlated with obesity parameters. While comparing parameters by gender we found a significant difference in height (p lt 0.01), WHR (p lt 0.001), uric acid levels (p lt 0.01) and HOMA-IR (p lt 0.01). Conclusion: Our results show a link between obesity, inflammation and dyslipidemia in children and adolescents. In the future, resistin could become a significant clinical marker for evaluation of cardiometabolic risk.
AB  - Uvod: Gojaznost u dečjem uzrastu se povezuje sa razvojem kardiovaskularnih bolesti i tipa 2 dijabetes melitusa u kasnijem dobu. Smatra se da je rezistin, adipokin kojeg u humanom organizumu luče monociti i tkivne makrofage, povezan sa ovim poremećajima. Cilj: Ispitati povezanost koncentracije rezistina kod gojazne dece i adolescenata sa antropometrijskim parametrima gojaznosti, lipidnim statusom, inflamatornim markerima i parametrima insulinske rezistencije. Materijal i metode: U istraživanju je učestvovalo 66 ispitanika (40 dečaka, 26 devojčica) kojima su izvršena antropometrijska merenja i laboratorijska ispitivanja (koncentracije glukoze, ukupnog holesterola, holesterola u česticama lipoproteina visoke gustine (eng. high-density lipoprotein, HDL) i niske gustine (eng. low-density lipoprotein, LDL), triglicerida, mokraćne kiseline, visokoosetljivog C-reaktivnog proteina (high-sensitivity C-reactive protein; hsCRP) i glikoziliranog hemoglobina (HbA1c)). Insulinska rezistencija je procenjena na osnovu modela za izračunavanje indeksa insulinske rezistencije (eng. homeostasis model assessment of insulin resistance; HOMA-IR). Rezultati: Kod 63,3% ispitanika utvrdili smo prisutnu dislipidemiju, a dobijene vrednosti hsCRP i mokraćne kiseline ukazuju na prisustvo inflamacije. Utvrdili smo korelaciju između koncentracije rezistina i odnosa obima struka i kukova (r=0,294, p lt 0,05) i između koncentracije rezistina i HOMA-IR (r=0,293, p lt 0,05). Ustanovili smo povezanost koncentracije mokraćne kiseline i parametara gojaznosti. Upoređivanjem parametara između polova, značajna razlika postoji u telesnoj visini (p lt 0,01), odnosu obima struka i kukova (p lt 0,001), mokraćnoj kiselini (p lt 0,01) i HOMA-IR (p lt 0,01). Zaključak: Naši rezultati ukazuju na povezanost gojaznosti, inflamacije i dislipidemije kod dece i adolescenata. Rezistin bi u budućnosti mogao biti značajan za procenu kardiometaboličkog rizika u ovoj populaciji.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Resistin, inflammation and dyslipidemia in obese children and adolescents
T1  - Rezistin, inflamacija i dislipidemija kod gojazne dece i adolescenata
VL  - 65
IS  - 2
SP  - 115
EP  - 128
DO  - 10.5937/arhfarm1502115P
ER  - 

@article{
author = "Pavlović, Branko and Milosavljević, Jovana and Zeljković, Aleksandra and Vekić, Jelena and Joksić, Jelena and Sopić, Miron and Spasojević-Kalimanovska, Vesna and Paripović, Dušan and Peco-Antić, Amira and Miloševski-Lomić, Gordana and Jelić-Ivanović, Zorana",
year = "2015",
abstract = "Introduction: Childhood obesity is related to cardiovascular diseases and diabetes mellitus type 2 in later life. Resistin, an adipokine primarily secreted by monocytes and tissue macrophages in humans, is considered to be associated with these conditions. The Aim: To examine the correlations between resistin concentration and anthropometric parameters, lipid status, inflammatory markers and parameters of insulin resistance in obese children and adolescents. Material and Methods: The study included 66 patients (40 boys, 26 girls), which underwent anthropometric measuring and laboratory testing (glucose level, total cholesterol, high-density lipoprotein cholesterol (HDL-cholesterol), low-density lipoprotein cholesterol (LDL-cholesterol), triglycerides, uric acid, high-sensitivity C-reactive protein (hsCRP) and glycosylated hemoglobin (HbA1c). Insulin resistance was estimated with HOMA-IR (homeostasis model assessment of insulin resistance). Results: We determined that 63.3% of our patients had dyslipidemia, while hsCRP and uric acid levels suggested an ongoing inflammation. We established that there was a correlation between resistin concentration and waist to hip ratio (WHR) (r=0.294, p lt 0.05), as well as between resistin concentration and HOMA-IR (r=0.293, p lt 0.05). Also, uric acid levels correlated with obesity parameters. While comparing parameters by gender we found a significant difference in height (p lt 0.01), WHR (p lt 0.001), uric acid levels (p lt 0.01) and HOMA-IR (p lt 0.01). Conclusion: Our results show a link between obesity, inflammation and dyslipidemia in children and adolescents. In the future, resistin could become a significant clinical marker for evaluation of cardiometabolic risk., Uvod: Gojaznost u dečjem uzrastu se povezuje sa razvojem kardiovaskularnih bolesti i tipa 2 dijabetes melitusa u kasnijem dobu. Smatra se da je rezistin, adipokin kojeg u humanom organizumu luče monociti i tkivne makrofage, povezan sa ovim poremećajima. Cilj: Ispitati povezanost koncentracije rezistina kod gojazne dece i adolescenata sa antropometrijskim parametrima gojaznosti, lipidnim statusom, inflamatornim markerima i parametrima insulinske rezistencije. Materijal i metode: U istraživanju je učestvovalo 66 ispitanika (40 dečaka, 26 devojčica) kojima su izvršena antropometrijska merenja i laboratorijska ispitivanja (koncentracije glukoze, ukupnog holesterola, holesterola u česticama lipoproteina visoke gustine (eng. high-density lipoprotein, HDL) i niske gustine (eng. low-density lipoprotein, LDL), triglicerida, mokraćne kiseline, visokoosetljivog C-reaktivnog proteina (high-sensitivity C-reactive protein; hsCRP) i glikoziliranog hemoglobina (HbA1c)). Insulinska rezistencija je procenjena na osnovu modela za izračunavanje indeksa insulinske rezistencije (eng. homeostasis model assessment of insulin resistance; HOMA-IR). Rezultati: Kod 63,3% ispitanika utvrdili smo prisutnu dislipidemiju, a dobijene vrednosti hsCRP i mokraćne kiseline ukazuju na prisustvo inflamacije. Utvrdili smo korelaciju između koncentracije rezistina i odnosa obima struka i kukova (r=0,294, p lt 0,05) i između koncentracije rezistina i HOMA-IR (r=0,293, p lt 0,05). Ustanovili smo povezanost koncentracije mokraćne kiseline i parametara gojaznosti. Upoređivanjem parametara između polova, značajna razlika postoji u telesnoj visini (p lt 0,01), odnosu obima struka i kukova (p lt 0,001), mokraćnoj kiselini (p lt 0,01) i HOMA-IR (p lt 0,01). Zaključak: Naši rezultati ukazuju na povezanost gojaznosti, inflamacije i dislipidemije kod dece i adolescenata. Rezistin bi u budućnosti mogao biti značajan za procenu kardiometaboličkog rizika u ovoj populaciji.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Resistin, inflammation and dyslipidemia in obese children and adolescents, Rezistin, inflamacija i dislipidemija kod gojazne dece i adolescenata",
volume = "65",
number = "2",
pages = "115-128",
doi = "10.5937/arhfarm1502115P"
}

Pavlović, B., Milosavljević, J., Zeljković, A., Vekić, J., Joksić, J., Sopić, M., Spasojević-Kalimanovska, V., Paripović, D., Peco-Antić, A., Miloševski-Lomić, G.,& Jelić-Ivanović, Z.. (2015). Resistin, inflammation and dyslipidemia in obese children and adolescents. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 65(2), 115-128.
https://doi.org/10.5937/arhfarm1502115P

Pavlović B, Milosavljević J, Zeljković A, Vekić J, Joksić J, Sopić M, Spasojević-Kalimanovska V, Paripović D, Peco-Antić A, Miloševski-Lomić G, Jelić-Ivanović Z. Resistin, inflammation and dyslipidemia in obese children and adolescents. in Arhiv za farmaciju. 2015;65(2):115-128.
doi:10.5937/arhfarm1502115P .

Pavlović, Branko, Milosavljević, Jovana, Zeljković, Aleksandra, Vekić, Jelena, Joksić, Jelena, Sopić, Miron, Spasojević-Kalimanovska, Vesna, Paripović, Dušan, Peco-Antić, Amira, Miloševski-Lomić, Gordana, Jelić-Ivanović, Zorana, "Resistin, inflammation and dyslipidemia in obese children and adolescents" in Arhiv za farmaciju, 65, no. 2 (2015):115-128,
https://doi.org/10.5937/arhfarm1502115P . .

TY  - JOUR
AU  - Petrović, Stanislava
AU  - Bogavac-Stanojević, Nataša
AU  - Kotur-Stevuljević, Jelena
AU  - Peco-Antić, Amira
AU  - Ivanišević, Ivana
AU  - Ivanišević, Jasmina
AU  - Paripović, Dušan
AU  - Jelić-Ivanović, Zorana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2195
AB  - Introduction: Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children. The aim of this study was to determine the total prooxidant and antioxidant capacity of children with UTI, as well as changes of oxidative status parameters according to acute inflammation persistence and acute kidney injury (AKI) development. Materials and methods: The patients enrolled in the study comprised 50 Caucasian children (median age was 6 months) with UTI. Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), inflammation marker C-reactive protein (CRP) and renal function parameters urea and creatinine were analyzed in patient's serums. Results: According to duration of inflammation during UTI, TAS values were significantly higher (0.99 vs. 0.58 mmol/L, P = 0.017) and OSI values were significantly lower (0.032 vs. 0.041 AU, P = 0.037) in the subjects with longer duration of inflammation than in the subjects with shorter duration of inflammation. We did not find significant difference in basal values of oxidative status parameters according to AKI development. Conclusions: OSI values could detect the simultaneous change of TAS and TOS due to change in the oxidative-antioxidant balance during the recovery of children with UTI. TAS and OSI as markers of oxidative stress during UTI are sensitive to accompanying inflammatory condition. Further investigations are needed to evaluate whether TAS, TOS and OSI could be used to monitor disease severity in children with UTI.
PB  - Croatian Soc Medical Biochemists, Zagreb
T2  - Biochemia Medica
T1  - Oxidative status parameters in children with urinary tract infection
VL  - 24
IS  - 2
SP  - 266
EP  - 272
DO  - 10.11613/BM.2014.029
ER  - 

@article{
author = "Petrović, Stanislava and Bogavac-Stanojević, Nataša and Kotur-Stevuljević, Jelena and Peco-Antić, Amira and Ivanišević, Ivana and Ivanišević, Jasmina and Paripović, Dušan and Jelić-Ivanović, Zorana",
year = "2014",
abstract = "Introduction: Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children. The aim of this study was to determine the total prooxidant and antioxidant capacity of children with UTI, as well as changes of oxidative status parameters according to acute inflammation persistence and acute kidney injury (AKI) development. Materials and methods: The patients enrolled in the study comprised 50 Caucasian children (median age was 6 months) with UTI. Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), inflammation marker C-reactive protein (CRP) and renal function parameters urea and creatinine were analyzed in patient's serums. Results: According to duration of inflammation during UTI, TAS values were significantly higher (0.99 vs. 0.58 mmol/L, P = 0.017) and OSI values were significantly lower (0.032 vs. 0.041 AU, P = 0.037) in the subjects with longer duration of inflammation than in the subjects with shorter duration of inflammation. We did not find significant difference in basal values of oxidative status parameters according to AKI development. Conclusions: OSI values could detect the simultaneous change of TAS and TOS due to change in the oxidative-antioxidant balance during the recovery of children with UTI. TAS and OSI as markers of oxidative stress during UTI are sensitive to accompanying inflammatory condition. Further investigations are needed to evaluate whether TAS, TOS and OSI could be used to monitor disease severity in children with UTI.",
publisher = "Croatian Soc Medical Biochemists, Zagreb",
journal = "Biochemia Medica",
title = "Oxidative status parameters in children with urinary tract infection",
volume = "24",
number = "2",
pages = "266-272",
doi = "10.11613/BM.2014.029"
}

Petrović, S., Bogavac-Stanojević, N., Kotur-Stevuljević, J., Peco-Antić, A., Ivanišević, I., Ivanišević, J., Paripović, D.,& Jelić-Ivanović, Z.. (2014). Oxidative status parameters in children with urinary tract infection. in Biochemia Medica
Croatian Soc Medical Biochemists, Zagreb., 24(2), 266-272.
https://doi.org/10.11613/BM.2014.029

Petrović S, Bogavac-Stanojević N, Kotur-Stevuljević J, Peco-Antić A, Ivanišević I, Ivanišević J, Paripović D, Jelić-Ivanović Z. Oxidative status parameters in children with urinary tract infection. in Biochemia Medica. 2014;24(2):266-272.
doi:10.11613/BM.2014.029 .

Petrović, Stanislava, Bogavac-Stanojević, Nataša, Kotur-Stevuljević, Jelena, Peco-Antić, Amira, Ivanišević, Ivana, Ivanišević, Jasmina, Paripović, Dušan, Jelić-Ivanović, Zorana, "Oxidative status parameters in children with urinary tract infection" in Biochemia Medica, 24, no. 2 (2014):266-272,
https://doi.org/10.11613/BM.2014.029 . .

TY  - JOUR
AU  - Ivanišević, Ivana
AU  - Peco-Antić, Amira
AU  - Vulicević, Irena
AU  - Hercog, Đorđe
AU  - Milovanović, Vladimir
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Kocev, Nikola
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1995
AB  - Acute kidney injury (AKI) is a common postoperative complication following cardiopulmonary bypass (CPB) surgery. New biomarkers to identify patients with early AKI (before increases in serum creatinine) are needed to facilitate appropriate treatment. This study aimed to test the role of urinary liver fatty-acid-binding protein (L-FABP) as an early biomarker for AKI in children undergoing CPB surgery. This is a case-control study of children undergoing CPB. AKI was defined as 50 % increase in serum creatinine at 48 h after surgery. For each patient, five serum and urine samples were obtained corresponding to time 0 h (presurgery) and 2, 6, 24, and 48 h after surgery. Twenty-seven patients, median age 360 days, were enrolled. AKI developed in 11 patients (41 %); three needed renal replacement therapy (peritoneal dialysis); there were two deaths. There were significant differences between patients with and without AKI in L-FABP levels at 2, 6, and 48 h after surgery, length of hospital stay, and CPB time; there were no differences in gender, patient age, and body weight. L-FABP was normalized to urinary creatinine concentration at all time points, with area under the receiver operator curve (AUC ROC) 0.867 at 2 and 6 h postoperatively. Correlation coefficient between L-FABP and length of hospital stay after surgery was statistically significant (r = 0.722, p value = 0.000). Our results suggest that urinary L-FABP can be used to diagnose AKI earlier than rise in serum creatinine in children undergoing CPB.
PB  - Springer, New York
T2  - Pediatric Nephrology
T1  - L-FABP can be an early marker of acute kidney injury in children
VL  - 28
IS  - 6
SP  - 963
EP  - 969
DO  - 10.1007/s00467-013-2421-z
ER  - 

@article{
author = "Ivanišević, Ivana and Peco-Antić, Amira and Vulicević, Irena and Hercog, Đorđe and Milovanović, Vladimir and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Kocev, Nikola",
year = "2013",
abstract = "Acute kidney injury (AKI) is a common postoperative complication following cardiopulmonary bypass (CPB) surgery. New biomarkers to identify patients with early AKI (before increases in serum creatinine) are needed to facilitate appropriate treatment. This study aimed to test the role of urinary liver fatty-acid-binding protein (L-FABP) as an early biomarker for AKI in children undergoing CPB surgery. This is a case-control study of children undergoing CPB. AKI was defined as 50 % increase in serum creatinine at 48 h after surgery. For each patient, five serum and urine samples were obtained corresponding to time 0 h (presurgery) and 2, 6, 24, and 48 h after surgery. Twenty-seven patients, median age 360 days, were enrolled. AKI developed in 11 patients (41 %); three needed renal replacement therapy (peritoneal dialysis); there were two deaths. There were significant differences between patients with and without AKI in L-FABP levels at 2, 6, and 48 h after surgery, length of hospital stay, and CPB time; there were no differences in gender, patient age, and body weight. L-FABP was normalized to urinary creatinine concentration at all time points, with area under the receiver operator curve (AUC ROC) 0.867 at 2 and 6 h postoperatively. Correlation coefficient between L-FABP and length of hospital stay after surgery was statistically significant (r = 0.722, p value = 0.000). Our results suggest that urinary L-FABP can be used to diagnose AKI earlier than rise in serum creatinine in children undergoing CPB.",
publisher = "Springer, New York",
journal = "Pediatric Nephrology",
title = "L-FABP can be an early marker of acute kidney injury in children",
volume = "28",
number = "6",
pages = "963-969",
doi = "10.1007/s00467-013-2421-z"
}

Ivanišević, I., Peco-Antić, A., Vulicević, I., Hercog, Đ., Milovanović, V., Kotur-Stevuljević, J., Stefanović, A.,& Kocev, N.. (2013). L-FABP can be an early marker of acute kidney injury in children. in Pediatric Nephrology
Springer, New York., 28(6), 963-969.
https://doi.org/10.1007/s00467-013-2421-z

Ivanišević I, Peco-Antić A, Vulicević I, Hercog Đ, Milovanović V, Kotur-Stevuljević J, Stefanović A, Kocev N. L-FABP can be an early marker of acute kidney injury in children. in Pediatric Nephrology. 2013;28(6):963-969.
doi:10.1007/s00467-013-2421-z .

Ivanišević, Ivana, Peco-Antić, Amira, Vulicević, Irena, Hercog, Đorđe, Milovanović, Vladimir, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Kocev, Nikola, "L-FABP can be an early marker of acute kidney injury in children" in Pediatric Nephrology, 28, no. 6 (2013):963-969,
https://doi.org/10.1007/s00467-013-2421-z . .

TY  - JOUR
AU  - Kotur-Stevuljević, Jelena
AU  - Peco-Antić, Amira
AU  - Spasić, Slavica
AU  - Stefanović, Aleksandra
AU  - Paripović, Dušan
AU  - Kostić, Mirjana
AU  - Vasić, Dragan
AU  - Vujović, Ana
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kornić-Ristovski, Danijela
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1943
AB  - The roles of dyslipidemia and oxidative stress in the early phases of atherosclerosis were tested in children with chronic kidney disease (CKD). Intima media thickness of common carotid arteries (cIMT) is used as a measure of early atherosclerosis. Fifty-two pediatric CKD patients were enrolled in the study (10 with chronic renal failure [CRF], 22 with a renal transplant [RT], 20 with chronic hemodialysis (cHD) patients, and 36 healthy children (control group, CG). Lipid status, oxidative stress, and paraoxonase 1 (PON1) status were assessed. cIMT was measured by ultrasound, adjusted for age and sex, and presented as standard deviation scores (SDS). Children with CKD had disturbed lipid content, which was most pronounced in cHD children, with higher free cholesterol and triglycerides compared with healthy children. Oxidative stress was markedly increased (malodialdehyde [MDA, mu mol/L]: CRF 1.50 +/- 0.26, RT 1.55 +/- 0.40, cHD 1.77 +/- 0.34, CG 0.97 +/- 0.33, p  lt  0.001) and antioxidative defense was compromised (superoxide dismutase [SOD, U/L]: CG 120 +/- 21, CRF 84 +/- 25, RT 93 +/- 12, cHD 119 +/- 37, p  lt  0.001). Multiple linear regression analysis showed that a model that included disease duration, blood pressure, urea, lipid, and oxidative status parameters accounted for more than 90% of the variability of cIMT-SDS. Early atherosclerosis in CKD children is caused, at least in part, by dyslipidemia and oxidative stress. Monitoring of vessel wall changes, along with assessment of oxidative stress status and high density lipoprotein (HDL) functionality is necessary to ensure better therapeutic strategies for delaying atherosclerotic changes in their asymptomatic phase.
PB  - Springer, New York
T2  - Pediatric Nephrology
T1  - Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease
VL  - 28
IS  - 2
SP  - 295
EP  - 303
DO  - 10.1007/s00467-012-2323-5
ER  - 

@article{
author = "Kotur-Stevuljević, Jelena and Peco-Antić, Amira and Spasić, Slavica and Stefanović, Aleksandra and Paripović, Dušan and Kostić, Mirjana and Vasić, Dragan and Vujović, Ana and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Kornić-Ristovski, Danijela",
year = "2013",
abstract = "The roles of dyslipidemia and oxidative stress in the early phases of atherosclerosis were tested in children with chronic kidney disease (CKD). Intima media thickness of common carotid arteries (cIMT) is used as a measure of early atherosclerosis. Fifty-two pediatric CKD patients were enrolled in the study (10 with chronic renal failure [CRF], 22 with a renal transplant [RT], 20 with chronic hemodialysis (cHD) patients, and 36 healthy children (control group, CG). Lipid status, oxidative stress, and paraoxonase 1 (PON1) status were assessed. cIMT was measured by ultrasound, adjusted for age and sex, and presented as standard deviation scores (SDS). Children with CKD had disturbed lipid content, which was most pronounced in cHD children, with higher free cholesterol and triglycerides compared with healthy children. Oxidative stress was markedly increased (malodialdehyde [MDA, mu mol/L]: CRF 1.50 +/- 0.26, RT 1.55 +/- 0.40, cHD 1.77 +/- 0.34, CG 0.97 +/- 0.33, p  lt  0.001) and antioxidative defense was compromised (superoxide dismutase [SOD, U/L]: CG 120 +/- 21, CRF 84 +/- 25, RT 93 +/- 12, cHD 119 +/- 37, p  lt  0.001). Multiple linear regression analysis showed that a model that included disease duration, blood pressure, urea, lipid, and oxidative status parameters accounted for more than 90% of the variability of cIMT-SDS. Early atherosclerosis in CKD children is caused, at least in part, by dyslipidemia and oxidative stress. Monitoring of vessel wall changes, along with assessment of oxidative stress status and high density lipoprotein (HDL) functionality is necessary to ensure better therapeutic strategies for delaying atherosclerotic changes in their asymptomatic phase.",
publisher = "Springer, New York",
journal = "Pediatric Nephrology",
title = "Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease",
volume = "28",
number = "2",
pages = "295-303",
doi = "10.1007/s00467-012-2323-5"
}

Kotur-Stevuljević, J., Peco-Antić, A., Spasić, S., Stefanović, A., Paripović, D., Kostić, M., Vasić, D., Vujović, A., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V.,& Kornić-Ristovski, D.. (2013). Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease. in Pediatric Nephrology
Springer, New York., 28(2), 295-303.
https://doi.org/10.1007/s00467-012-2323-5

Kotur-Stevuljević J, Peco-Antić A, Spasić S, Stefanović A, Paripović D, Kostić M, Vasić D, Vujović A, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Kornić-Ristovski D. Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease. in Pediatric Nephrology. 2013;28(2):295-303.
doi:10.1007/s00467-012-2323-5 .

Kotur-Stevuljević, Jelena, Peco-Antić, Amira, Spasić, Slavica, Stefanović, Aleksandra, Paripović, Dušan, Kostić, Mirjana, Vasić, Dragan, Vujović, Ana, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Kornić-Ristovski, Danijela, "Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease" in Pediatric Nephrology, 28, no. 2 (2013):295-303,
https://doi.org/10.1007/s00467-012-2323-5 . .

TY  - JOUR
AU  - Petrović, Stanislava
AU  - Bogavac-Stanojević, Nataša
AU  - Peco-Antić, Amira
AU  - Ivanišević, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Paripović, Dušan
AU  - Sopić, Miron
AU  - Jelić-Ivanović, Zorana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1971
AB  - Background. The aim of this study was to examine the novel renal biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) to assist pediatricians in the assessment of longer duration of inflammation and acute kidney injury (AKI) development during urinary tract infection (UTI). Methods. The patients enrolled in the study comprised 50 children (mean age was 6 months) with UTI. NGAL in serum and urine (sNGAL and uNGAL, resp.) and KIM-1 in urine were measured by enzyme-linked immunosorbent assays. Results. uNGAL levels in subjects with longer duration of inflammation were higher (115.37 ng/mL) than uNGAL levels in subjects with shorter duration of inflammation (67.87 ng/mL, P = 0.022). Difference in sNGAL and KIM-1 levels was not significant (P = 0.155 and P = 0.198, resp.). Significant difference was seen in KIM-1 excretion among groups with and without AKI (P = 0.038). KIM-1 was not able to discriminate between subjects with and without AKI (area under the curves (AUC) = 0.620, P = 0.175). Conclusions. uNGAL cannot be used for screening of the duration of inflammation during UTI. Accuracy of KIM-1 in screening of AKI development in children with UTI is low. We suggest larger studies to check the negative predictive value of KIM-1 for the development of AKI.
PB  - Hindawi Publishing Corporation, New York
T2  - Biomed Research International
T1  - Clinical Application Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 as Indicators of Inflammation Persistence and Acute Kidney Injury in Children with Urinary Tract Infection
DO  - 10.1155/2013/947157
ER  - 

@article{
author = "Petrović, Stanislava and Bogavac-Stanojević, Nataša and Peco-Antić, Amira and Ivanišević, Ivana and Kotur-Stevuljević, Jelena and Paripović, Dušan and Sopić, Miron and Jelić-Ivanović, Zorana",
year = "2013",
abstract = "Background. The aim of this study was to examine the novel renal biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) to assist pediatricians in the assessment of longer duration of inflammation and acute kidney injury (AKI) development during urinary tract infection (UTI). Methods. The patients enrolled in the study comprised 50 children (mean age was 6 months) with UTI. NGAL in serum and urine (sNGAL and uNGAL, resp.) and KIM-1 in urine were measured by enzyme-linked immunosorbent assays. Results. uNGAL levels in subjects with longer duration of inflammation were higher (115.37 ng/mL) than uNGAL levels in subjects with shorter duration of inflammation (67.87 ng/mL, P = 0.022). Difference in sNGAL and KIM-1 levels was not significant (P = 0.155 and P = 0.198, resp.). Significant difference was seen in KIM-1 excretion among groups with and without AKI (P = 0.038). KIM-1 was not able to discriminate between subjects with and without AKI (area under the curves (AUC) = 0.620, P = 0.175). Conclusions. uNGAL cannot be used for screening of the duration of inflammation during UTI. Accuracy of KIM-1 in screening of AKI development in children with UTI is low. We suggest larger studies to check the negative predictive value of KIM-1 for the development of AKI.",
publisher = "Hindawi Publishing Corporation, New York",
journal = "Biomed Research International",
title = "Clinical Application Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 as Indicators of Inflammation Persistence and Acute Kidney Injury in Children with Urinary Tract Infection",
doi = "10.1155/2013/947157"
}

Petrović, S., Bogavac-Stanojević, N., Peco-Antić, A., Ivanišević, I., Kotur-Stevuljević, J., Paripović, D., Sopić, M.,& Jelić-Ivanović, Z.. (2013). Clinical Application Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 as Indicators of Inflammation Persistence and Acute Kidney Injury in Children with Urinary Tract Infection. in Biomed Research International
Hindawi Publishing Corporation, New York..
https://doi.org/10.1155/2013/947157

Petrović S, Bogavac-Stanojević N, Peco-Antić A, Ivanišević I, Kotur-Stevuljević J, Paripović D, Sopić M, Jelić-Ivanović Z. Clinical Application Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 as Indicators of Inflammation Persistence and Acute Kidney Injury in Children with Urinary Tract Infection. in Biomed Research International. 2013;.
doi:10.1155/2013/947157 .

Petrović, Stanislava, Bogavac-Stanojević, Nataša, Peco-Antić, Amira, Ivanišević, Ivana, Kotur-Stevuljević, Jelena, Paripović, Dušan, Sopić, Miron, Jelić-Ivanović, Zorana, "Clinical Application Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 as Indicators of Inflammation Persistence and Acute Kidney Injury in Children with Urinary Tract Infection" in Biomed Research International (2013),
https://doi.org/10.1155/2013/947157 . .

TY  - JOUR
AU  - Peco-Antić, Amira
AU  - Ivanišević, Ivana
AU  - Vulicević, Irena
AU  - Kotur-Stevuljević, Jelena
AU  - Ilić, Slobodan
AU  - Ivanišević, Jasmina
AU  - Miljković, Milica
AU  - Kocev, Nikola
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1893
AB  - Objectives: Acute kidney injury (AKI) is a significant problem in children undergoing cardiopulmonary bypass (CPB). The aims of this study were to assess the diagnostic validity of serum CysC (sCysC), serum neutrophil gelatinase lipocalin (sNGAL), urine neutrophil gelatinase lipocalin (uNGAL), urine kidney injury molecule (uKIM)-1, and urine liver fatty acid-binding protein (uL-FABP) to predict AKI presence and severity in children undergoing CPB. Design and methods: We performed a prospective single-center evaluation of sCysC, sNGAL, uNGAL, uKIM-1 and uL-FABP at 0, 2, 6, 24 and 48 h postoperatively in children undergoing CPB during cardiac surgery. AKI was defined as >= 25% decrease in the estimated creatinine clearance (eCCl) from pre-operative baseline at 48 h after surgery. Results: Of the 112 patients, 18 patients (16.1%) developed AKI; four of them needed acute dialysis treatment and three AKI patients died. In the AKI compared to the non-AM group, sCysC at 2 h, and uNGAL and uL-FABP at 2-48 h were significantly increased, as well as CPB, aortic cross clamp time and length of hospital stay. Biomarkers increased with worsening AKI severity. At 2 h after CPB the best accuracy for diagnosis of AKI had uL-FABP and sCysC with area under the receiver operator curve (AUC) of 0.89 and 0.73, respectively. At 6 and 24 h after CPB the best AUC was found for uL-FABP (0.75 and 0.87 respectively) and for uNGAL (0.70 and 0.93, respectively). Conclusions: sCysC, uNGAL and uL-FABP are reliable early predictors for AKI after CPB. By allowing earlier timing of injury and earlier intervention, they could improve AKI outcome.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Biomarkers of acute kidney injury in pediatric cardiac surgery
VL  - 46
IS  - 13-14
SP  - 1244
EP  - 1251
DO  - 10.1016/j.clinbiochem.2013.07.008
ER  - 

@article{
author = "Peco-Antić, Amira and Ivanišević, Ivana and Vulicević, Irena and Kotur-Stevuljević, Jelena and Ilić, Slobodan and Ivanišević, Jasmina and Miljković, Milica and Kocev, Nikola",
year = "2013",
abstract = "Objectives: Acute kidney injury (AKI) is a significant problem in children undergoing cardiopulmonary bypass (CPB). The aims of this study were to assess the diagnostic validity of serum CysC (sCysC), serum neutrophil gelatinase lipocalin (sNGAL), urine neutrophil gelatinase lipocalin (uNGAL), urine kidney injury molecule (uKIM)-1, and urine liver fatty acid-binding protein (uL-FABP) to predict AKI presence and severity in children undergoing CPB. Design and methods: We performed a prospective single-center evaluation of sCysC, sNGAL, uNGAL, uKIM-1 and uL-FABP at 0, 2, 6, 24 and 48 h postoperatively in children undergoing CPB during cardiac surgery. AKI was defined as >= 25% decrease in the estimated creatinine clearance (eCCl) from pre-operative baseline at 48 h after surgery. Results: Of the 112 patients, 18 patients (16.1%) developed AKI; four of them needed acute dialysis treatment and three AKI patients died. In the AKI compared to the non-AM group, sCysC at 2 h, and uNGAL and uL-FABP at 2-48 h were significantly increased, as well as CPB, aortic cross clamp time and length of hospital stay. Biomarkers increased with worsening AKI severity. At 2 h after CPB the best accuracy for diagnosis of AKI had uL-FABP and sCysC with area under the receiver operator curve (AUC) of 0.89 and 0.73, respectively. At 6 and 24 h after CPB the best AUC was found for uL-FABP (0.75 and 0.87 respectively) and for uNGAL (0.70 and 0.93, respectively). Conclusions: sCysC, uNGAL and uL-FABP are reliable early predictors for AKI after CPB. By allowing earlier timing of injury and earlier intervention, they could improve AKI outcome.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Biomarkers of acute kidney injury in pediatric cardiac surgery",
volume = "46",
number = "13-14",
pages = "1244-1251",
doi = "10.1016/j.clinbiochem.2013.07.008"
}

Peco-Antić, A., Ivanišević, I., Vulicević, I., Kotur-Stevuljević, J., Ilić, S., Ivanišević, J., Miljković, M.,& Kocev, N.. (2013). Biomarkers of acute kidney injury in pediatric cardiac surgery. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 46(13-14), 1244-1251.
https://doi.org/10.1016/j.clinbiochem.2013.07.008

Peco-Antić A, Ivanišević I, Vulicević I, Kotur-Stevuljević J, Ilić S, Ivanišević J, Miljković M, Kocev N. Biomarkers of acute kidney injury in pediatric cardiac surgery. in Clinical Biochemistry. 2013;46(13-14):1244-1251.
doi:10.1016/j.clinbiochem.2013.07.008 .

Peco-Antić, Amira, Ivanišević, Ivana, Vulicević, Irena, Kotur-Stevuljević, Jelena, Ilić, Slobodan, Ivanišević, Jasmina, Miljković, Milica, Kocev, Nikola, "Biomarkers of acute kidney injury in pediatric cardiac surgery" in Clinical Biochemistry, 46, no. 13-14 (2013):1244-1251,
https://doi.org/10.1016/j.clinbiochem.2013.07.008 . .

TY  - CONF
AU  - Peco-Antić, Amira
AU  - Vukicević, Irena
AU  - Kotur, Jelena
AU  - Hercog, Đorđe
AU  - Milovanović, Vladimir
AU  - Ivanišević, Jasmina
AU  - Ivanišević, Ivana
AU  - Miljković, Milica
AU  - Kocev, Nikola
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1741
PB  - Springer, New York
C3  - Pediatric Nephrology
T1  - Biomarkers of acute kidney injury in pediatric cardiac surgery
VL  - 27
IS  - 9
SP  - 1620
EP  - 1620
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1741
ER  - 

@conference{
author = "Peco-Antić, Amira and Vukicević, Irena and Kotur, Jelena and Hercog, Đorđe and Milovanović, Vladimir and Ivanišević, Jasmina and Ivanišević, Ivana and Miljković, Milica and Kocev, Nikola",
year = "2012",
publisher = "Springer, New York",
journal = "Pediatric Nephrology",
title = "Biomarkers of acute kidney injury in pediatric cardiac surgery",
volume = "27",
number = "9",
pages = "1620-1620",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1741"
}

Peco-Antić, A., Vukicević, I., Kotur, J., Hercog, Đ., Milovanović, V., Ivanišević, J., Ivanišević, I., Miljković, M.,& Kocev, N.. (2012). Biomarkers of acute kidney injury in pediatric cardiac surgery. in Pediatric Nephrology
Springer, New York., 27(9), 1620-1620.
https://hdl.handle.net/21.15107/rcub_farfar_1741

Peco-Antić A, Vukicević I, Kotur J, Hercog Đ, Milovanović V, Ivanišević J, Ivanišević I, Miljković M, Kocev N. Biomarkers of acute kidney injury in pediatric cardiac surgery. in Pediatric Nephrology. 2012;27(9):1620-1620.
https://hdl.handle.net/21.15107/rcub_farfar_1741 .

Peco-Antić, Amira, Vukicević, Irena, Kotur, Jelena, Hercog, Đorđe, Milovanović, Vladimir, Ivanišević, Jasmina, Ivanišević, Ivana, Miljković, Milica, Kocev, Nikola, "Biomarkers of acute kidney injury in pediatric cardiac surgery" in Pediatric Nephrology, 27, no. 9 (2012):1620-1620,
https://hdl.handle.net/21.15107/rcub_farfar_1741 .

TY  - JOUR
AU  - Peco-Antić, Amira
AU  - Paripović, Dušan
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Scekić, Gordana
AU  - Miloševski-Lomić, Gordana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1625
AB  - Objective: The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK). Material and methods: RFR was obtained from the difference of endogenous creatinine clearance (CrCs) before and after a meat-free oral protein load (OPL) in the patients who were pre-treated with cimetidine. Serum cystatin C and urinary protein excretion were determined before and after OPL Results: Among 22 patients (13 boys), aged 9.5 +/- 4.3years, 72.7% had increased serum cystatin C, and 54.5% had decreased RFR. Following OPL, CrCs and urine creatinine increased, while serum creatinine and cystatin C remained unchanged. The multiple regression analysis demonstrated that cystatin C could predict more than 90% of RFR variability. Conclusion: Half of the patients with apparently normal SFK had decreased RFR. Serum cystatin C is one of the best predictors of RFR.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Renal functional reserve in children with apparently normal congenital solitary functioning kidney
VL  - 45
IS  - 15
SP  - 1173
EP  - 1177
DO  - 10.1016/j.clinbiochem.2012.06.018
ER  - 

@article{
author = "Peco-Antić, Amira and Paripović, Dušan and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Scekić, Gordana and Miloševski-Lomić, Gordana",
year = "2012",
abstract = "Objective: The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK). Material and methods: RFR was obtained from the difference of endogenous creatinine clearance (CrCs) before and after a meat-free oral protein load (OPL) in the patients who were pre-treated with cimetidine. Serum cystatin C and urinary protein excretion were determined before and after OPL Results: Among 22 patients (13 boys), aged 9.5 +/- 4.3years, 72.7% had increased serum cystatin C, and 54.5% had decreased RFR. Following OPL, CrCs and urine creatinine increased, while serum creatinine and cystatin C remained unchanged. The multiple regression analysis demonstrated that cystatin C could predict more than 90% of RFR variability. Conclusion: Half of the patients with apparently normal SFK had decreased RFR. Serum cystatin C is one of the best predictors of RFR.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Renal functional reserve in children with apparently normal congenital solitary functioning kidney",
volume = "45",
number = "15",
pages = "1173-1177",
doi = "10.1016/j.clinbiochem.2012.06.018"
}

Peco-Antić, A., Paripović, D., Kotur-Stevuljević, J., Stefanović, A., Scekić, G.,& Miloševski-Lomić, G.. (2012). Renal functional reserve in children with apparently normal congenital solitary functioning kidney. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 45(15), 1173-1177.
https://doi.org/10.1016/j.clinbiochem.2012.06.018

Peco-Antić A, Paripović D, Kotur-Stevuljević J, Stefanović A, Scekić G, Miloševski-Lomić G. Renal functional reserve in children with apparently normal congenital solitary functioning kidney. in Clinical Biochemistry. 2012;45(15):1173-1177.
doi:10.1016/j.clinbiochem.2012.06.018 .

Peco-Antić, Amira, Paripović, Dušan, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Scekić, Gordana, Miloševski-Lomić, Gordana, "Renal functional reserve in children with apparently normal congenital solitary functioning kidney" in Clinical Biochemistry, 45, no. 15 (2012):1173-1177,
https://doi.org/10.1016/j.clinbiochem.2012.06.018 . .

TY  - CONF
AU  - Peco-Antić, Amira
AU  - Kotur-Stevuljević, Jelena
AU  - Paripović, Dušan
AU  - Scekić, Gordana
AU  - Miloševski-Lomić, Gordana
AU  - Bogićević, Dragana
AU  - Spasojević-Dimitrijeva, Brankica
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1678
PB  - Oxford Univ Press, Oxford
C3  - Nephrology Dialysis Transplantation
T1  - Renal functional reserve in children with solitary kidney and chronic renal failure
VL  - 27
SP  - 546
EP  - 546
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1678
ER  - 

@conference{
author = "Peco-Antić, Amira and Kotur-Stevuljević, Jelena and Paripović, Dušan and Scekić, Gordana and Miloševski-Lomić, Gordana and Bogićević, Dragana and Spasojević-Dimitrijeva, Brankica",
year = "2012",
publisher = "Oxford Univ Press, Oxford",
journal = "Nephrology Dialysis Transplantation",
title = "Renal functional reserve in children with solitary kidney and chronic renal failure",
volume = "27",
pages = "546-546",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1678"
}

Peco-Antić, A., Kotur-Stevuljević, J., Paripović, D., Scekić, G., Miloševski-Lomić, G., Bogićević, D.,& Spasojević-Dimitrijeva, B.. (2012). Renal functional reserve in children with solitary kidney and chronic renal failure. in Nephrology Dialysis Transplantation
Oxford Univ Press, Oxford., 27, 546-546.
https://hdl.handle.net/21.15107/rcub_farfar_1678

Peco-Antić A, Kotur-Stevuljević J, Paripović D, Scekić G, Miloševski-Lomić G, Bogićević D, Spasojević-Dimitrijeva B. Renal functional reserve in children with solitary kidney and chronic renal failure. in Nephrology Dialysis Transplantation. 2012;27:546-546.
https://hdl.handle.net/21.15107/rcub_farfar_1678 .

Peco-Antić, Amira, Kotur-Stevuljević, Jelena, Paripović, Dušan, Scekić, Gordana, Miloševski-Lomić, Gordana, Bogićević, Dragana, Spasojević-Dimitrijeva, Brankica, "Renal functional reserve in children with solitary kidney and chronic renal failure" in Nephrology Dialysis Transplantation, 27 (2012):546-546,
https://hdl.handle.net/21.15107/rcub_farfar_1678 .

TY  - CONF
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Peco-Antić, Amira
AU  - Kostić, Mirjana
AU  - Vasić, Dragan
AU  - Spasić, Slavica
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1460
PB  - Elsevier Science BV, Amsterdam
C3  - European Journal of Pharmaceutical Sciences
T1  - Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients
VL  - 44
IS  - Supplement 1
SP  - 191
EP  - 191
DO  - 10.1016/j.ejps.2011.08.002
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1460
ER  - 

@conference{
author = "Zeljković, Aleksandra and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Peco-Antić, Amira and Kostić, Mirjana and Vasić, Dragan and Spasić, Slavica",
year = "2011",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients",
volume = "44",
number = "Supplement 1",
pages = "191-191",
doi = "10.1016/j.ejps.2011.08.002",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1460"
}

Zeljković, A., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Peco-Antić, A., Kostić, M., Vasić, D.,& Spasić, S.. (2011). Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 44(Supplement 1), 191-191.
https://doi.org/10.1016/j.ejps.2011.08.002
https://hdl.handle.net/21.15107/rcub_farfar_1460

Zeljković A, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Peco-Antić A, Kostić M, Vasić D, Spasić S. Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients. in European Journal of Pharmaceutical Sciences. 2011;44(Supplement 1):191-191.
doi:10.1016/j.ejps.2011.08.002
https://hdl.handle.net/21.15107/rcub_farfar_1460 .

Zeljković, Aleksandra, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Peco-Antić, Amira, Kostić, Mirjana, Vasić, Dragan, Spasić, Slavica, "Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients" in European Journal of Pharmaceutical Sciences, 44, no. Supplement 1 (2011):191-191,
https://doi.org/10.1016/j.ejps.2011.08.002 .,
https://hdl.handle.net/21.15107/rcub_farfar_1460 .

TY  - CONF
AU  - Spasić, S.
AU  - Kotur-Stevuljević, Jelena
AU  - Peco-Antić, Amira
AU  - Kostić, M.
AU  - Vasić, Dragan
AU  - Stefanović, Aleksandra
AU  - Vujović, Ana
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kornić, D.
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1486
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis Supplements
T1  - Hyperlipidemia and oxidative stress are the main determinants of intima-media thickness in children with chronic kidney disease
VL  - 12
IS  - 1
SP  - 22
EP  - 22
DO  - 10.1016/S1567-5688(11)70094-0
ER  - 

@conference{
author = "Spasić, S. and Kotur-Stevuljević, Jelena and Peco-Antić, Amira and Kostić, M. and Vasić, Dragan and Stefanović, Aleksandra and Vujović, Ana and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Kornić, D.",
year = "2011",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis Supplements",
title = "Hyperlipidemia and oxidative stress are the main determinants of intima-media thickness in children with chronic kidney disease",
volume = "12",
number = "1",
pages = "22-22",
doi = "10.1016/S1567-5688(11)70094-0"
}

Spasić, S., Kotur-Stevuljević, J., Peco-Antić, A., Kostić, M., Vasić, D., Stefanović, A., Vujović, A., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V.,& Kornić, D.. (2011). Hyperlipidemia and oxidative stress are the main determinants of intima-media thickness in children with chronic kidney disease. in Atherosclerosis Supplements
Elsevier Ireland Ltd, Clare., 12(1), 22-22.
https://doi.org/10.1016/S1567-5688(11)70094-0

Spasić S, Kotur-Stevuljević J, Peco-Antić A, Kostić M, Vasić D, Stefanović A, Vujović A, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Kornić D. Hyperlipidemia and oxidative stress are the main determinants of intima-media thickness in children with chronic kidney disease. in Atherosclerosis Supplements. 2011;12(1):22-22.
doi:10.1016/S1567-5688(11)70094-0 .

Spasić, S., Kotur-Stevuljević, Jelena, Peco-Antić, Amira, Kostić, M., Vasić, Dragan, Stefanović, Aleksandra, Vujović, Ana, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Kornić, D., "Hyperlipidemia and oxidative stress are the main determinants of intima-media thickness in children with chronic kidney disease" in Atherosclerosis Supplements, 12, no. 1 (2011):22-22,
https://doi.org/10.1016/S1567-5688(11)70094-0 . .

TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Peco-Antić, Amira
AU  - Kostić, Mirjana
AU  - Vasić, Dragan
AU  - Spasić, Slavica
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1549
AB  - Renal transplant recipients often suffer from dyslipidemia which is one of the principal risk factors for cardiovascular disease. This study sought to determine characteristics of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles and their associations with carotid intima-media thickness (cIMT) in a group of pediatric renal transplant recipients. We also examined the influence of immunosuppressive therapy on measured LDL and HDL particle characteristics. HDL size and subclass distribution were determined using gradient gel electrophoresis, while concentrations of small, dense LDL (sdLDL)-cholesterol (sdLDL-C) and sdLDL-apolipoprotein B (sdLDL-apoB) using heparin-magnesium precipitation method in 21 renal transplant recipients and 32 controls. Renal transplant recipients had less HDL 2b (P  lt  0.001), but more HDL 3a (P  lt  0.01) and 3b (P  lt  0.001) subclasses. They also had increased sdLDL-C (P  lt  0.01) and sdLDL-apoB (P  lt  0.05) levels. The proportion of the HDL 3b subclasses was a significant predictor of increased cIMT (P  lt  0.05). Patients treated with cyclosporine had significantly higher sdLDL-C and sdLDL-apoB concentrations (P  lt  0.05) when compared with those on tacrolimus therapy. Pediatric renal transplant recipients have impaired distribution of HDL and LDL particles. Changes in the proportion of small-sized HDL particles are significantly associated with cIMT. Advanced lipid testing might be useful in evaluating the effects of immunosuppressive therapy.
PB  - Wiley-Blackwell, Malden
T2  - Transplantation
T1  - Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients
VL  - 24
IS  - 11
SP  - 1094
EP  - 1102
DO  - 10.1111/j.1432-2277.2011.01313.x
ER  - 

@article{
author = "Zeljković, Aleksandra and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Peco-Antić, Amira and Kostić, Mirjana and Vasić, Dragan and Spasić, Slavica",
year = "2011",
abstract = "Renal transplant recipients often suffer from dyslipidemia which is one of the principal risk factors for cardiovascular disease. This study sought to determine characteristics of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles and their associations with carotid intima-media thickness (cIMT) in a group of pediatric renal transplant recipients. We also examined the influence of immunosuppressive therapy on measured LDL and HDL particle characteristics. HDL size and subclass distribution were determined using gradient gel electrophoresis, while concentrations of small, dense LDL (sdLDL)-cholesterol (sdLDL-C) and sdLDL-apolipoprotein B (sdLDL-apoB) using heparin-magnesium precipitation method in 21 renal transplant recipients and 32 controls. Renal transplant recipients had less HDL 2b (P  lt  0.001), but more HDL 3a (P  lt  0.01) and 3b (P  lt  0.001) subclasses. They also had increased sdLDL-C (P  lt  0.01) and sdLDL-apoB (P  lt  0.05) levels. The proportion of the HDL 3b subclasses was a significant predictor of increased cIMT (P  lt  0.05). Patients treated with cyclosporine had significantly higher sdLDL-C and sdLDL-apoB concentrations (P  lt  0.05) when compared with those on tacrolimus therapy. Pediatric renal transplant recipients have impaired distribution of HDL and LDL particles. Changes in the proportion of small-sized HDL particles are significantly associated with cIMT. Advanced lipid testing might be useful in evaluating the effects of immunosuppressive therapy.",
publisher = "Wiley-Blackwell, Malden",
journal = "Transplantation",
title = "Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients",
volume = "24",
number = "11",
pages = "1094-1102",
doi = "10.1111/j.1432-2277.2011.01313.x"
}

Zeljković, A., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Peco-Antić, A., Kostić, M., Vasić, D.,& Spasić, S.. (2011). Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients. in Transplantation
Wiley-Blackwell, Malden., 24(11), 1094-1102.
https://doi.org/10.1111/j.1432-2277.2011.01313.x

Zeljković A, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Peco-Antić A, Kostić M, Vasić D, Spasić S. Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients. in Transplantation. 2011;24(11):1094-1102.
doi:10.1111/j.1432-2277.2011.01313.x .

Zeljković, Aleksandra, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Peco-Antić, Amira, Kostić, Mirjana, Vasić, Dragan, Spasić, Slavica, "Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients" in Transplantation, 24, no. 11 (2011):1094-1102,
https://doi.org/10.1111/j.1432-2277.2011.01313.x . .

TY  - JOUR
AU  - Radisavljević, Snežana
AU  - Peco-Antić, Amira
AU  - Kotur-Stevuljević, Jelena
AU  - Savić, Olivera
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1384
AB  - Introduction Balkan endemic nephropathy (BEN) is a familial chronic progressive tubulointerstitial disease of unknown aetiology that occurs with high prevalence in endemic rural environments of Serbia, Bosnia and Herzegovina, Croatia, Bulgaria and Romania. It has been documented only in adults. Objective The aim of this study was to examine clinical markers of BEN in children and adolescent offspring of BEN patients. Methods Prospective clinical trial involved two groups of children and adolescents: I consisted of 30 offspring of BEN patients and II of 29 offspring of non-BEN dialysis patients, both of them living in the same South Morava region of Serbia. All of them were healthy at the time of the investigation, not receiving any drugs. The study included personal and family history, physical examination, comprehensive laboratory analyses and renal ultrasound. Blood pressure (BP) was determined by using casual BP and 24 h ABPM in subjects older than 5 years. Urinary proteins were investigated by analysing microalbumin, alfa 1 microglobulin, beta 2 rnicroglobulin and SDS-PAGE electrophoresis. GFR was measured by estimated creatinine clearance and by serum Cystatin C concentrations. Results There were no statistically significant differences in age, gender, history of urinary tract infections or functional voiding disorders between these two groups. All of the studied subjects had normal BP and GFR. Renal ultrasound was abnormal only in BEN offspring (6.66%) as well as increased urine concentrations of microalbumin (3.3%), alpha 1 microglobulin (10%) and beta 2 microglobulin (13.3%) while low molecular protein ( lt 66,000 D) was prevalent in BEN compared with non-BEN offspring (21.43% vs. 3.7%). Conclusion Renal abnormalities in offspring of BEN patients may be an early marker of BEN. This has to be confirmed in long term follow-up of a greater number of BEN paediatric offspring.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Structural and Functional Characteristics of Urinary Tract in Offspring of Balkan Endemic Nephropathy Patients
VL  - 138
IS  - 3-4
SP  - 204
EP  - 209
DO  - 10.2298/SARH1004204R
ER  - 

@article{
author = "Radisavljević, Snežana and Peco-Antić, Amira and Kotur-Stevuljević, Jelena and Savić, Olivera",
year = "2010",
abstract = "Introduction Balkan endemic nephropathy (BEN) is a familial chronic progressive tubulointerstitial disease of unknown aetiology that occurs with high prevalence in endemic rural environments of Serbia, Bosnia and Herzegovina, Croatia, Bulgaria and Romania. It has been documented only in adults. Objective The aim of this study was to examine clinical markers of BEN in children and adolescent offspring of BEN patients. Methods Prospective clinical trial involved two groups of children and adolescents: I consisted of 30 offspring of BEN patients and II of 29 offspring of non-BEN dialysis patients, both of them living in the same South Morava region of Serbia. All of them were healthy at the time of the investigation, not receiving any drugs. The study included personal and family history, physical examination, comprehensive laboratory analyses and renal ultrasound. Blood pressure (BP) was determined by using casual BP and 24 h ABPM in subjects older than 5 years. Urinary proteins were investigated by analysing microalbumin, alfa 1 microglobulin, beta 2 rnicroglobulin and SDS-PAGE electrophoresis. GFR was measured by estimated creatinine clearance and by serum Cystatin C concentrations. Results There were no statistically significant differences in age, gender, history of urinary tract infections or functional voiding disorders between these two groups. All of the studied subjects had normal BP and GFR. Renal ultrasound was abnormal only in BEN offspring (6.66%) as well as increased urine concentrations of microalbumin (3.3%), alpha 1 microglobulin (10%) and beta 2 microglobulin (13.3%) while low molecular protein ( lt 66,000 D) was prevalent in BEN compared with non-BEN offspring (21.43% vs. 3.7%). Conclusion Renal abnormalities in offspring of BEN patients may be an early marker of BEN. This has to be confirmed in long term follow-up of a greater number of BEN paediatric offspring.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Structural and Functional Characteristics of Urinary Tract in Offspring of Balkan Endemic Nephropathy Patients",
volume = "138",
number = "3-4",
pages = "204-209",
doi = "10.2298/SARH1004204R"
}

Radisavljević, S., Peco-Antić, A., Kotur-Stevuljević, J.,& Savić, O.. (2010). Structural and Functional Characteristics of Urinary Tract in Offspring of Balkan Endemic Nephropathy Patients. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 138(3-4), 204-209.
https://doi.org/10.2298/SARH1004204R

Radisavljević S, Peco-Antić A, Kotur-Stevuljević J, Savić O. Structural and Functional Characteristics of Urinary Tract in Offspring of Balkan Endemic Nephropathy Patients. in Srpski arhiv za celokupno lekarstvo. 2010;138(3-4):204-209.
doi:10.2298/SARH1004204R .

Radisavljević, Snežana, Peco-Antić, Amira, Kotur-Stevuljević, Jelena, Savić, Olivera, "Structural and Functional Characteristics of Urinary Tract in Offspring of Balkan Endemic Nephropathy Patients" in Srpski arhiv za celokupno lekarstvo, 138, no. 3-4 (2010):204-209,
https://doi.org/10.2298/SARH1004204R . .