TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Ninić, Ana
PY  - 2021
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4004
AB  - Various studies have reported contradictory results regarding the relationship of total bilirubin and high‑sensitivity C‑reactive protein levels (hsCRP) with diabetes mellitus Type 2 (DM2). Therefore, we aimed to examine which one of them could be more convenient for the estimation of DM2 risk in postmenopausal women. Materials and Methods: A total of 150 healthy postmenopausal women (mean age 57[53–60] years) and 79 postmenopausal women with DM2 (mean age 66 [61–71] years) were enrolled in cross‑sectional study. Examinees were recruited consecutively in the study during their regular check‑up visit in the Primary Health Care Center in Podgorica, Montenegro, in a period from October 2012 to May 2016. Anthropometric measurements, biochemical parameters, and blood pressure were obtained. Multivariable logistic regression analysis was used to find the independent predictors for DM2 development in postmenopausal women. Results: Age, waist circumference, and total bilirubin were the independent predictors for DM2 development in postmenopausal women (odds ratio [OR] =1.224, 95% confidence interval [CI] [1.117–1.341], P < 0.001; OR = 1.137, [95% CI = 1.036–1.215], P < 0.001, and OR = 0.727, [95% CI = 0.611–0.866], P < 0.001, respectively), whereas hsCRP lost its independent predictive role (OR = 1.155, [95% CI = 0.854–1.560], P = 0.349). Conclusion: Unlike hsCRP, total bilirubin independently correlated with DM2 in postmenopausal women.
PB  - Wolters Kluwer Medknow Publications
T2  - Journal of Research in Medical Sciences
T1  - Are total bilirubin and high-sensitivity C-reactive protein independently associated with Type 2 diabetes mellitus in postmenopausal women?
VL  - 26
IS  - 1
DO  - 10.4103/jrms.JRMS_198_18
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Ninić, Ana",
year = "2021, 2021",
abstract = "Various studies have reported contradictory results regarding the relationship of total bilirubin and high‑sensitivity C‑reactive protein levels (hsCRP) with diabetes mellitus Type 2 (DM2). Therefore, we aimed to examine which one of them could be more convenient for the estimation of DM2 risk in postmenopausal women. Materials and Methods: A total of 150 healthy postmenopausal women (mean age 57[53–60] years) and 79 postmenopausal women with DM2 (mean age 66 [61–71] years) were enrolled in cross‑sectional study. Examinees were recruited consecutively in the study during their regular check‑up visit in the Primary Health Care Center in Podgorica, Montenegro, in a period from October 2012 to May 2016. Anthropometric measurements, biochemical parameters, and blood pressure were obtained. Multivariable logistic regression analysis was used to find the independent predictors for DM2 development in postmenopausal women. Results: Age, waist circumference, and total bilirubin were the independent predictors for DM2 development in postmenopausal women (odds ratio [OR] =1.224, 95% confidence interval [CI] [1.117–1.341], P < 0.001; OR = 1.137, [95% CI = 1.036–1.215], P < 0.001, and OR = 0.727, [95% CI = 0.611–0.866], P < 0.001, respectively), whereas hsCRP lost its independent predictive role (OR = 1.155, [95% CI = 0.854–1.560], P = 0.349). Conclusion: Unlike hsCRP, total bilirubin independently correlated with DM2 in postmenopausal women.",
publisher = "Wolters Kluwer Medknow Publications",
journal = "Journal of Research in Medical Sciences",
title = "Are total bilirubin and high-sensitivity C-reactive protein independently associated with Type 2 diabetes mellitus in postmenopausal women?",
volume = "26",
number = "1",
doi = "10.4103/jrms.JRMS_198_18"
}

Klisić, A., Kavarić, N.,& Ninić, A.. (2021). Are total bilirubin and high-sensitivity C-reactive protein independently associated with Type 2 diabetes mellitus in postmenopausal women?. in Journal of Research in Medical Sciences
Wolters Kluwer Medknow Publications., 26(1).
https://doi.org/10.4103/jrms.JRMS_198_18

Klisić A, Kavarić N, Ninić A. Are total bilirubin and high-sensitivity C-reactive protein independently associated with Type 2 diabetes mellitus in postmenopausal women?. in Journal of Research in Medical Sciences. 2021;26(1).
doi:10.4103/jrms.JRMS_198_18 .

Klisić, Aleksandra, Kavarić, Nebojša, Ninić, Ana, "Are total bilirubin and high-sensitivity C-reactive protein independently associated with Type 2 diabetes mellitus in postmenopausal women?" in Journal of Research in Medical Sciences, 26, no. 1 (2021),
https://doi.org/10.4103/jrms.JRMS_198_18 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kotur-Stevuljević, Jelena
AU  - Ninić, Ana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3773
AB  - Background:Association  between  endocan  and  non-traditional  anthropometric  indices,  as  distinct  cardio  -vascular  disease  risk  factors,  has  not  been  examined  inprevious   studies.   Endocan   is   a   novel   inflammationbiomarker with its higher levels involved in cardiometabolicdiseases  development.  Taking  into  consideration  thatobesity  is  an  independent  risk  factor  for  many  cardio  -metabolic  diseases,  we  aimed  to  explore  the  relationshipbetween endocan levels and novel anthropometric indices i.e.,  body  adiposity  index  (BAI),  cardiometabolic  index(CMI), a body shape index, body roundness index, conicityindex,  lipid  accumulation  product  index  and  visceraladiposity  index and  traditional  ones   i.e.,  waist  circum  -ference,  hip  circumference,  body  mass  index,  waist-to-height ratio and waist-to-hip ratio in adult population.Methods:A  total  of  177  participants  were  included.Anthropometric indices and biochemical parametres weremeasured. Results:Univariate  regression  analysis  demonstrated  posi-tive correlations of endocan and almost all anthropometricdata. To explore independent associations of endocan andanthropometric parameters, the Model which fulfilled crite-ria  for  ordinal  regression  testing  was  created.  Adjusted odds  for  BAI  given  in  the  Model  (OR=1.120,  95%  CI1.036–1.212, P=0.004), demonstrated that a rise in BAIby 1 unit increased the probability of higher endocan con-centration  by  12%.  As  well,  a  rise  in  CMI  for  1  unit,increased the probability for higher endocan levels for 2.6times  (OR=2.599,  95%  CI  1.006–6.712,  P=0.049).  Atotal  of  20.1%  of  variation  in  endocan  levels  could  beexplained by this Model.Conclusions:Non-traditional obesity indices, BAI and CMIindependently correlated with higher serum endocan levelsin adult population.
AB  - Uvod: Povezanost endokana sa netradicionalnim antropometrijskim parametrima, kao različitim faktorima rizika za kardiovaskularne bolesti, nije ispitivana u prethodnim studijama. Endokan je novi biomarker inflamacije, čije su veće vrednosti zabeležene kod kardiometaboličkih poremećaja. Znajući da je gojaznost nezavisan faktor rizika za mnoga kardiometabolička oboljenja, cilj je bio da se ispita povezanost endokana i novih antropometrijskih pokazatelja tj. indeks telesne gojaznosti (BAI), kardiometabolički indeks (CMI), indeks oblika tela, indeks zaokruženosti tela, indeks koniciteta, indeks produkata lipidne akumulacije i indeks visceralne gojaznosti i onih tradicionalnih tj. obim struka, obim kukova, indeks telesne mase, odnos obim struka/telesna visina, odnos obim struka/obim kukova u populaciji odraslih. Metode: Ukupno 177 ispitanika je učestvovalo u istraživanju. Mereni su antropometrijski i biohemijski parametri. Rezultati: Univarijantna regresiona analiza je pokazala pozitivnu korelaciju endokana i skoro svih ispitivanih antropometrijskih parametara. U cilju daljeg ispitivanja postojanja nezavisnih korelacija endokana i antropometrijskih parametara, kreiran je Model koji je zadovoljio kriterijume za ordinalnu regresiju. Prilagođeni Odds-ovi za BAI u Modelu (OR=1,120, 95% CI 1,036-1,212, P=0,004), su pokazali da je porast BAI za 1 jedinicu povećao verovatnoću za porast koncentracije endokana za 12%. Takođe, porast CMI za 1 jedinicu, povećao je verovatnoću za veće vrednosti endokana za 2,6 puta (OR=2,599, 95% CI 1,006-6,712, P=0,049). Ukupno 20,1% varijabiliteta u vrednostima koncentracije endokana može biti objašnjeno ovim Modelom. Zaključak: Netradicionalni pokazatelji gojaznosti, BAI i CMI su nezavisno povezani sa većim vrednostima endokana u populaciji odraslih.
PB  - Belgrade: Society of Medical Biochemists of Serbia
T2  - Journal of Medical Biochemistry
T1  - Serum endocan levels in relation to traditional and non-traditional anthropometric indices in adult population
T1  - Serumske vrednosti endokana u odnosu na tradicionalne i netradicionalne antropometrijske parametre u populaciji odraslih
VL  - 40
IS  - 1
SP  - 41
EP  - 48
DO  - 10.5937/jomb0-25170
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Spasojević-Kalimanovska, Vesna and Kotur-Stevuljević, Jelena and Ninić, Ana",
year = "2021",
abstract = "Background:Association  between  endocan  and  non-traditional  anthropometric  indices,  as  distinct  cardio  -vascular  disease  risk  factors,  has  not  been  examined  inprevious   studies.   Endocan   is   a   novel   inflammationbiomarker with its higher levels involved in cardiometabolicdiseases  development.  Taking  into  consideration  thatobesity  is  an  independent  risk  factor  for  many  cardio  -metabolic  diseases,  we  aimed  to  explore  the  relationshipbetween endocan levels and novel anthropometric indices i.e.,  body  adiposity  index  (BAI),  cardiometabolic  index(CMI), a body shape index, body roundness index, conicityindex,  lipid  accumulation  product  index  and  visceraladiposity  index and  traditional  ones   i.e.,  waist  circum  -ference,  hip  circumference,  body  mass  index,  waist-to-height ratio and waist-to-hip ratio in adult population.Methods:A  total  of  177  participants  were  included.Anthropometric indices and biochemical parametres weremeasured. Results:Univariate  regression  analysis  demonstrated  posi-tive correlations of endocan and almost all anthropometricdata. To explore independent associations of endocan andanthropometric parameters, the Model which fulfilled crite-ria  for  ordinal  regression  testing  was  created.  Adjusted odds  for  BAI  given  in  the  Model  (OR=1.120,  95%  CI1.036–1.212, P=0.004), demonstrated that a rise in BAIby 1 unit increased the probability of higher endocan con-centration  by  12%.  As  well,  a  rise  in  CMI  for  1  unit,increased the probability for higher endocan levels for 2.6times  (OR=2.599,  95%  CI  1.006–6.712,  P=0.049).  Atotal  of  20.1%  of  variation  in  endocan  levels  could  beexplained by this Model.Conclusions:Non-traditional obesity indices, BAI and CMIindependently correlated with higher serum endocan levelsin adult population., Uvod: Povezanost endokana sa netradicionalnim antropometrijskim parametrima, kao različitim faktorima rizika za kardiovaskularne bolesti, nije ispitivana u prethodnim studijama. Endokan je novi biomarker inflamacije, čije su veće vrednosti zabeležene kod kardiometaboličkih poremećaja. Znajući da je gojaznost nezavisan faktor rizika za mnoga kardiometabolička oboljenja, cilj je bio da se ispita povezanost endokana i novih antropometrijskih pokazatelja tj. indeks telesne gojaznosti (BAI), kardiometabolički indeks (CMI), indeks oblika tela, indeks zaokruženosti tela, indeks koniciteta, indeks produkata lipidne akumulacije i indeks visceralne gojaznosti i onih tradicionalnih tj. obim struka, obim kukova, indeks telesne mase, odnos obim struka/telesna visina, odnos obim struka/obim kukova u populaciji odraslih. Metode: Ukupno 177 ispitanika je učestvovalo u istraživanju. Mereni su antropometrijski i biohemijski parametri. Rezultati: Univarijantna regresiona analiza je pokazala pozitivnu korelaciju endokana i skoro svih ispitivanih antropometrijskih parametara. U cilju daljeg ispitivanja postojanja nezavisnih korelacija endokana i antropometrijskih parametara, kreiran je Model koji je zadovoljio kriterijume za ordinalnu regresiju. Prilagođeni Odds-ovi za BAI u Modelu (OR=1,120, 95% CI 1,036-1,212, P=0,004), su pokazali da je porast BAI za 1 jedinicu povećao verovatnoću za porast koncentracije endokana za 12%. Takođe, porast CMI za 1 jedinicu, povećao je verovatnoću za veće vrednosti endokana za 2,6 puta (OR=2,599, 95% CI 1,006-6,712, P=0,049). Ukupno 20,1% varijabiliteta u vrednostima koncentracije endokana može biti objašnjeno ovim Modelom. Zaključak: Netradicionalni pokazatelji gojaznosti, BAI i CMI su nezavisno povezani sa većim vrednostima endokana u populaciji odraslih.",
publisher = "Belgrade: Society of Medical Biochemists of Serbia",
journal = "Journal of Medical Biochemistry",
title = "Serum endocan levels in relation to traditional and non-traditional anthropometric indices in adult population, Serumske vrednosti endokana u odnosu na tradicionalne i netradicionalne antropometrijske parametre u populaciji odraslih",
volume = "40",
number = "1",
pages = "41-48",
doi = "10.5937/jomb0-25170"
}

Klisić, A., Kavarić, N., Spasojević-Kalimanovska, V., Kotur-Stevuljević, J.,& Ninić, A.. (2021). Serum endocan levels in relation to traditional and non-traditional anthropometric indices in adult population. in Journal of Medical Biochemistry
Belgrade: Society of Medical Biochemists of Serbia., 40(1), 41-48.
https://doi.org/10.5937/jomb0-25170

Klisić A, Kavarić N, Spasojević-Kalimanovska V, Kotur-Stevuljević J, Ninić A. Serum endocan levels in relation to traditional and non-traditional anthropometric indices in adult population. in Journal of Medical Biochemistry. 2021;40(1):41-48.
doi:10.5937/jomb0-25170 .

Klisić, Aleksandra, Kavarić, Nebojša, Spasojević-Kalimanovska, Vesna, Kotur-Stevuljević, Jelena, Ninić, Ana, "Serum endocan levels in relation to traditional and non-traditional anthropometric indices in adult population" in Journal of Medical Biochemistry, 40, no. 1 (2021):41-48,
https://doi.org/10.5937/jomb0-25170 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Ninić, Ana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3717
AB  - Introduction/Objective Given the contradictory results regarding the association of liver function biomarkers [e.g., alanine-aminotransferase (ALT), gamma-glutamyl transferase (GGT) and total biliru-bin)] and the risk of cardiovascular disease (CVD), we aimed to explore the relationship between these biomarkers and Framingham risk score (FRS), an established tool used in the prediction of 10-year CVD risk in the cohort of women.Methods A total of 278 women participated in this cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained.Results There was a significant increase in ALT and GGT activity, as well as a decrease in total bilirubin level in the high-risk FRS group compared to moderate-, and low-risk FRS (p for trend = 0.025, p < 0.001, p < 0.001, respectively). Multivariate logistic regression analysis showed that body mass index, triglycer-ides, creatinine, and high sensitivity C-reactive protein levels were the independent predictors of FRS in women [odds ratio (OR) = 1.234, p = 0.001; OR = 2.856, p = 0.001; OR = 1.090, p = 0.002, and OR = 1.295, p = 0.045, respectively]. In contrast, total bilirubin, ALT and GGT lost their independent predictions for high CVD risk.
AB  - Увод/Циљ С обзиром на контрадикторне резултате који се односе на повезаност биомаркера функције јетре [аланин-аминотрансферазе (АЛТ), гама-глутамил трансферазе (ГГТ) и укупног билирубина)] и ризика за појаву кардиоваску-ларних болести, циљ студије је био да се испита повезаност између ових биомаркера и Фрамингхамског скора за ризик (ФСР), алгоритма за процену 10-годишњег ризика за појаву кардиоваскуларних болести у кохорти женске популације. Методе У овој студији пресека учествовало је укупно 278 жена. Мерени су антропометријски, биохемијски параметри и крвни притисак. Резултати Уочен је статистички значајан пораст активности АЛТ и ГГТ, као и пад вредности укупног билирубина у групи са високим статусом ФСР, у поређењу са средњим и ниским ФСР (p = 0,025, p < 0,001, p < 0,001, редом). Мултиваријантна логистичка регресиона анализа показала је да су индекс телесне масе, вредности триглицерида, креатинина и висо-коосетљивог c-реактивног протеина независни предиктори ФСР код жена (OR = 1,234, p = 0,001; OR = 2,856, p = 0,001; OR = 1,090, p = 0,002 и OR = 1,295, p = 0,045, редом). С друге стране, укупни билирубин, АЛТ и ГГТ су изгубили независну предикцију за високи ризик за појаву кардиоваскуларних болести.
PB  - Serbian Medical Society
T2  - Srpski Arhiv za Celokupno Lekarstvo
T1  - Are liver function biomarkers independently associated with framingham risk score in women?
T1  - Да ли су биомаркери функције јетре независно повезани са Фрамингхамским скором за ризик у женској популацији?
VL  - 148
IS  - 7-8
SP  - 423
EP  - 429
DO  - 10.2298/SARH181120006K
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Ninić, Ana",
year = "2020",
abstract = "Introduction/Objective Given the contradictory results regarding the association of liver function biomarkers [e.g., alanine-aminotransferase (ALT), gamma-glutamyl transferase (GGT) and total biliru-bin)] and the risk of cardiovascular disease (CVD), we aimed to explore the relationship between these biomarkers and Framingham risk score (FRS), an established tool used in the prediction of 10-year CVD risk in the cohort of women.Methods A total of 278 women participated in this cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained.Results There was a significant increase in ALT and GGT activity, as well as a decrease in total bilirubin level in the high-risk FRS group compared to moderate-, and low-risk FRS (p for trend = 0.025, p < 0.001, p < 0.001, respectively). Multivariate logistic regression analysis showed that body mass index, triglycer-ides, creatinine, and high sensitivity C-reactive protein levels were the independent predictors of FRS in women [odds ratio (OR) = 1.234, p = 0.001; OR = 2.856, p = 0.001; OR = 1.090, p = 0.002, and OR = 1.295, p = 0.045, respectively]. In contrast, total bilirubin, ALT and GGT lost their independent predictions for high CVD risk., Увод/Циљ С обзиром на контрадикторне резултате који се односе на повезаност биомаркера функције јетре [аланин-аминотрансферазе (АЛТ), гама-глутамил трансферазе (ГГТ) и укупног билирубина)] и ризика за појаву кардиоваску-ларних болести, циљ студије је био да се испита повезаност између ових биомаркера и Фрамингхамског скора за ризик (ФСР), алгоритма за процену 10-годишњег ризика за појаву кардиоваскуларних болести у кохорти женске популације. Методе У овој студији пресека учествовало је укупно 278 жена. Мерени су антропометријски, биохемијски параметри и крвни притисак. Резултати Уочен је статистички значајан пораст активности АЛТ и ГГТ, као и пад вредности укупног билирубина у групи са високим статусом ФСР, у поређењу са средњим и ниским ФСР (p = 0,025, p < 0,001, p < 0,001, редом). Мултиваријантна логистичка регресиона анализа показала је да су индекс телесне масе, вредности триглицерида, креатинина и висо-коосетљивог c-реактивног протеина независни предиктори ФСР код жена (OR = 1,234, p = 0,001; OR = 2,856, p = 0,001; OR = 1,090, p = 0,002 и OR = 1,295, p = 0,045, редом). С друге стране, укупни билирубин, АЛТ и ГГТ су изгубили независну предикцију за високи ризик за појаву кардиоваскуларних болести.",
publisher = "Serbian Medical Society",
journal = "Srpski Arhiv za Celokupno Lekarstvo",
title = "Are liver function biomarkers independently associated with framingham risk score in women?, Да ли су биомаркери функције јетре независно повезани са Фрамингхамским скором за ризик у женској популацији?",
volume = "148",
number = "7-8",
pages = "423-429",
doi = "10.2298/SARH181120006K"
}

Klisić, A., Kavarić, N.,& Ninić, A.. (2020). Are liver function biomarkers independently associated with framingham risk score in women?. in Srpski Arhiv za Celokupno Lekarstvo
Serbian Medical Society., 148(7-8), 423-429.
https://doi.org/10.2298/SARH181120006K

Klisić A, Kavarić N, Ninić A. Are liver function biomarkers independently associated with framingham risk score in women?. in Srpski Arhiv za Celokupno Lekarstvo. 2020;148(7-8):423-429.
doi:10.2298/SARH181120006K .

Klisić, Aleksandra, Kavarić, Nebojša, Ninić, Ana, "Are liver function biomarkers independently associated with framingham risk score in women?" in Srpski Arhiv za Celokupno Lekarstvo, 148, no. 7-8 (2020):423-429,
https://doi.org/10.2298/SARH181120006K . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Abenavoli, Ludovico
AU  - Stanišić, Verica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kotur-Stevuljević, Jelena
AU  - Ninić, Ana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3485
AB  - Studies that evaluated endocan levels in nonalcoholic fatty liver disease (NAFLD) and liver fibrosis are scarce. We aimed to explore endocan levels in relation to different stages of liver diseases, such as NAFLD, as determined with fatty liver index (FLI) and liver fibrosis, as assessed with BARD score. A total of 147 participants with FLI≥60 were compared with 64 participants with FLI <30. An FLI score was calculated using waist circumference, body mass index, gamma-glutamyl transferase and triglycerides. Patients with FLI≥60 were further divided into those with no/mild fibrosis (BARD score 0-1 point; n=23) and advanced fibrosis (BARD score 2-4 points; n=124). BARD score was calculated as follows: diabetes mellitus (1 point) + body mass index≥28 kg/m2 (1 point) + aspartate amino transferase/alanine aminotransferase ratio≥0.8 (2 points). Endocan was independent predictor for FLI and BARD score, both in univariate [OR=1.255 (95% CI= 1.104-1.426), P=0.001; OR=1.208 (95% CI=1.029- 1.419), P=0.021, respectively] and multivariate binary logistic regression analysis [OR=1.287 (95% CI=1.055- 1.570), P=0.013; OR=1.226 (95% CI=1.022-1.470), P=0.028, respectively]. Endocan as a single predictor showed poor discriminatory capability for steatosis/fibrosis [AUC=0.648; (95% CI=0.568-0.727), P=0.002; AUC= 0.667 (95% CI=0.555-0.778), P=0.013, respectively], whereas in a Model, endocan showed an excellent clinical accuracy [AUC=0.930; (95% CI=0.886-0.975), P<0.001, AUC=0.840 (95% CI=0.763-0.918), P<0.001, respectively]. Endocan independently correlated with both FLI and BARD score. However, when tested in models (with other biomarkers), endocan showed better discriminatory ability for liver steatosis/fibrosis, instead of its usage as a single biomarker
AB  - Uvod: Nema mnogo studija koje su ispitivale vrednosti endokana kod obolelih od nealkoholne steatoze i fibroze jetre. Naš cilj je bio da se ispita nivo endokana u različitim stadijumima oboljenja jetre, kao što su nealkoholna steatoza jetre, predstavljena indeksom masne jetre (FLI) i fibroza jetre, predstavljena BARD skorom. Metode: Ukupno 147 učesnika sa FLI≥60 poređeno je sa 64 učesnika sa FLI <30. FLI skor je izračunat koriste i vrednosti obim struka, indeksa telesne mase, aktivnosti gama-glutamil transferaze i vrednosti triglicerida. Ispitanici sa FLI≥60 su dalje podeljeni u 2 grupe: bez fibroze/blaga fibroza (BARD skor 0–1 poen; n=23) i uznapredovala fibroza (BARD skor 2–4 poena; n=124). BARD skor je računat na sledeći način: e erna bolest (1 poen) + indeks telesne mase≥28 kg/m2 (1 poen) + odnos aspartat aminotransferaza/alanin aminotransferaza≥0,8 (2 poena). Rezultati: Endokan je nezavisan prediktor FLI i BARD skora, kako u univarijantnoj [OR=1,255 (95% CI=1,104– 1,426), P=0,001; odnosno OR=1,208 (95% CI=1,029– 1,419), P=0,021], tako i u multivarijantnoj binarnoj logističkoj regresionoj analizi [OR=1.287 (95% CI=1,055– 1,570), P=0,013; odnosno OR=1,226 (95% CI=1,022– 1,470), P=0,028]. Endokan kao samostalan prediktor pokazao je slabu diskriminatornu mo za steatozu/fibrozu jetre [AUC=0,648; (95% CI=0,568–0,727), P=0,002; odnosno AUC=0,667 (95% CI=0,555–0,778), P=0,013], ali je u Modelu pokazao odličnu kliničku tačnost [AUC=0,930; (95% CI=0,886–0,975), P<0,001; odnosno AUC=0,840 (95% CI=0,763–0,918), P<0,001]. Zaključak: Endokan je nezavisno povezan kako sa FLI, tako i sa BARD skorom. Ipak, u modelu (sa drugim biomarkerima), endokan je pokazao bolju diskriminatornu sposobnost za steatozu/fibrozu jetre.
PB  - Belgrade: Society of Medical Biochemists of Serbia
T2  - Journal of Medical Biochemistry
T1  - Is endocan a novel potential biomarker of liver steatosis and fibrosis?
T1  - Da li je endokan novi potencijalni biomarker za steatozu i fibrozu jetre?
VL  - 39
IS  - 3
SP  - 363
EP  - 371
DO  - 10.2478/jomb-2019-0042
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Abenavoli, Ludovico and Stanišić, Verica and Spasojević-Kalimanovska, Vesna and Kotur-Stevuljević, Jelena and Ninić, Ana",
year = "2020",
abstract = "Studies that evaluated endocan levels in nonalcoholic fatty liver disease (NAFLD) and liver fibrosis are scarce. We aimed to explore endocan levels in relation to different stages of liver diseases, such as NAFLD, as determined with fatty liver index (FLI) and liver fibrosis, as assessed with BARD score. A total of 147 participants with FLI≥60 were compared with 64 participants with FLI <30. An FLI score was calculated using waist circumference, body mass index, gamma-glutamyl transferase and triglycerides. Patients with FLI≥60 were further divided into those with no/mild fibrosis (BARD score 0-1 point; n=23) and advanced fibrosis (BARD score 2-4 points; n=124). BARD score was calculated as follows: diabetes mellitus (1 point) + body mass index≥28 kg/m2 (1 point) + aspartate amino transferase/alanine aminotransferase ratio≥0.8 (2 points). Endocan was independent predictor for FLI and BARD score, both in univariate [OR=1.255 (95% CI= 1.104-1.426), P=0.001; OR=1.208 (95% CI=1.029- 1.419), P=0.021, respectively] and multivariate binary logistic regression analysis [OR=1.287 (95% CI=1.055- 1.570), P=0.013; OR=1.226 (95% CI=1.022-1.470), P=0.028, respectively]. Endocan as a single predictor showed poor discriminatory capability for steatosis/fibrosis [AUC=0.648; (95% CI=0.568-0.727), P=0.002; AUC= 0.667 (95% CI=0.555-0.778), P=0.013, respectively], whereas in a Model, endocan showed an excellent clinical accuracy [AUC=0.930; (95% CI=0.886-0.975), P<0.001, AUC=0.840 (95% CI=0.763-0.918), P<0.001, respectively]. Endocan independently correlated with both FLI and BARD score. However, when tested in models (with other biomarkers), endocan showed better discriminatory ability for liver steatosis/fibrosis, instead of its usage as a single biomarker, Uvod: Nema mnogo studija koje su ispitivale vrednosti endokana kod obolelih od nealkoholne steatoze i fibroze jetre. Naš cilj je bio da se ispita nivo endokana u različitim stadijumima oboljenja jetre, kao što su nealkoholna steatoza jetre, predstavljena indeksom masne jetre (FLI) i fibroza jetre, predstavljena BARD skorom. Metode: Ukupno 147 učesnika sa FLI≥60 poređeno je sa 64 učesnika sa FLI <30. FLI skor je izračunat koriste i vrednosti obim struka, indeksa telesne mase, aktivnosti gama-glutamil transferaze i vrednosti triglicerida. Ispitanici sa FLI≥60 su dalje podeljeni u 2 grupe: bez fibroze/blaga fibroza (BARD skor 0–1 poen; n=23) i uznapredovala fibroza (BARD skor 2–4 poena; n=124). BARD skor je računat na sledeći način: e erna bolest (1 poen) + indeks telesne mase≥28 kg/m2 (1 poen) + odnos aspartat aminotransferaza/alanin aminotransferaza≥0,8 (2 poena). Rezultati: Endokan je nezavisan prediktor FLI i BARD skora, kako u univarijantnoj [OR=1,255 (95% CI=1,104– 1,426), P=0,001; odnosno OR=1,208 (95% CI=1,029– 1,419), P=0,021], tako i u multivarijantnoj binarnoj logističkoj regresionoj analizi [OR=1.287 (95% CI=1,055– 1,570), P=0,013; odnosno OR=1,226 (95% CI=1,022– 1,470), P=0,028]. Endokan kao samostalan prediktor pokazao je slabu diskriminatornu mo za steatozu/fibrozu jetre [AUC=0,648; (95% CI=0,568–0,727), P=0,002; odnosno AUC=0,667 (95% CI=0,555–0,778), P=0,013], ali je u Modelu pokazao odličnu kliničku tačnost [AUC=0,930; (95% CI=0,886–0,975), P<0,001; odnosno AUC=0,840 (95% CI=0,763–0,918), P<0,001]. Zaključak: Endokan je nezavisno povezan kako sa FLI, tako i sa BARD skorom. Ipak, u modelu (sa drugim biomarkerima), endokan je pokazao bolju diskriminatornu sposobnost za steatozu/fibrozu jetre.",
publisher = "Belgrade: Society of Medical Biochemists of Serbia",
journal = "Journal of Medical Biochemistry",
title = "Is endocan a novel potential biomarker of liver steatosis and fibrosis?, Da li je endokan novi potencijalni biomarker za steatozu i fibrozu jetre?",
volume = "39",
number = "3",
pages = "363-371",
doi = "10.2478/jomb-2019-0042"
}

Klisić, A., Kavarić, N., Abenavoli, L., Stanišić, V., Spasojević-Kalimanovska, V., Kotur-Stevuljević, J.,& Ninić, A.. (2020). Is endocan a novel potential biomarker of liver steatosis and fibrosis?. in Journal of Medical Biochemistry
Belgrade: Society of Medical Biochemists of Serbia., 39(3), 363-371.
https://doi.org/10.2478/jomb-2019-0042

Klisić A, Kavarić N, Abenavoli L, Stanišić V, Spasojević-Kalimanovska V, Kotur-Stevuljević J, Ninić A. Is endocan a novel potential biomarker of liver steatosis and fibrosis?. in Journal of Medical Biochemistry. 2020;39(3):363-371.
doi:10.2478/jomb-2019-0042 .

Klisić, Aleksandra, Kavarić, Nebojša, Abenavoli, Ludovico, Stanišić, Verica, Spasojević-Kalimanovska, Vesna, Kotur-Stevuljević, Jelena, Ninić, Ana, "Is endocan a novel potential biomarker of liver steatosis and fibrosis?" in Journal of Medical Biochemistry, 39, no. 3 (2020):363-371,
https://doi.org/10.2478/jomb-2019-0042 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kocić, Gordana
AU  - Kavarić, Nebojša
AU  - Jovanović, M
AU  - Stanišić, Verica
AU  - Ninić, Ana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3142
AB  - Purpose: The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity. Methods: A total of 118 overweight/obese volunteers (mean age 54.76 ± 15.13 years) were included in the current cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained. Results: Significant differences between age, BMI, waist circumference, concentrations of uric acid and hsCRP, as well as xanthine dehydrogenase (XDH) activities were evident among XO tertile groups. Multiple linear regression analysis revealed that BMI (beta = 0.241, p = 0.012) and XDH (beta = − 0.489, p < 0.001) are the independent predictors of XO activity (R2-adjusted = 0.333), whereas hsCRP lost its independent role in XO activity prediction. Conclusion: Obesity (as determined with increased BMI) is an independent predictor of high XO activity in overweight/obese population. Level of Evidence: Level V: cross-sectional descriptive study.
PB  - Springer International Publishing
T2  - Eating and Weight Disorders
T1  - Body mass index is independently associated with xanthine oxidase activity in overweight/obese population
VL  - 25
IS  - 1
SP  - 9
EP  - 15
DO  - 10.1007/s40519-018-0490-5
ER  - 

@article{
author = "Klisić, Aleksandra and Kocić, Gordana and Kavarić, Nebojša and Jovanović, M and Stanišić, Verica and Ninić, Ana",
year = "2020",
abstract = "Purpose: The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity. Methods: A total of 118 overweight/obese volunteers (mean age 54.76 ± 15.13 years) were included in the current cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained. Results: Significant differences between age, BMI, waist circumference, concentrations of uric acid and hsCRP, as well as xanthine dehydrogenase (XDH) activities were evident among XO tertile groups. Multiple linear regression analysis revealed that BMI (beta = 0.241, p = 0.012) and XDH (beta = − 0.489, p < 0.001) are the independent predictors of XO activity (R2-adjusted = 0.333), whereas hsCRP lost its independent role in XO activity prediction. Conclusion: Obesity (as determined with increased BMI) is an independent predictor of high XO activity in overweight/obese population. Level of Evidence: Level V: cross-sectional descriptive study.",
publisher = "Springer International Publishing",
journal = "Eating and Weight Disorders",
title = "Body mass index is independently associated with xanthine oxidase activity in overweight/obese population",
volume = "25",
number = "1",
pages = "9-15",
doi = "10.1007/s40519-018-0490-5"
}

Klisić, A., Kocić, G., Kavarić, N., Jovanović, M., Stanišić, V.,& Ninić, A.. (2020). Body mass index is independently associated with xanthine oxidase activity in overweight/obese population. in Eating and Weight Disorders
Springer International Publishing., 25(1), 9-15.
https://doi.org/10.1007/s40519-018-0490-5

Klisić A, Kocić G, Kavarić N, Jovanović M, Stanišić V, Ninić A. Body mass index is independently associated with xanthine oxidase activity in overweight/obese population. in Eating and Weight Disorders. 2020;25(1):9-15.
doi:10.1007/s40519-018-0490-5 .

Klisić, Aleksandra, Kocić, Gordana, Kavarić, Nebojša, Jovanović, M, Stanišić, Verica, Ninić, Ana, "Body mass index is independently associated with xanthine oxidase activity in overweight/obese population" in Eating and Weight Disorders, 25, no. 1 (2020):9-15,
https://doi.org/10.1007/s40519-018-0490-5 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kocić, Gordana
AU  - Kavarić, Nebojša
AU  - Pavlović, Radmila
AU  - Soldatović, Ivan
AU  - Ninić, Ana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3342
AB  - Background: Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. Additionally, we aimed to evaluate a broad spectrum of other oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), xanthine oxidoreductase (XOD), xanthine oxidase (XO) xanthine dehydrogenase (XDH)] in relation with MetS. Methods: A total of 109 volunteers (46.8% of them with MetS) were included in this cross-sectional study. Biohemical and anthropometric parameters, as well as blood pressure, were obtained. The MetS was diagnosed according to the International Diabetes Federation criteria. Results: Multivariate logistic regression analysis showed that XOD (OR=1.011; 95% CI 1.002-1.019; p=0.016), XO (OR=1.014; 95% CI 1.003-1.026; p=0.016), MDA (OR=1.113; 95% CI 1.038-1.192; p=0.003) and AOPP (OR=1.022; 95% CI 1.005-1.039; p=0.012) were the independent predictors of MetS, whereas no association between NOx and MetS was found. As XOD rose for 1 U/L, XO for 1 U/L, MDA for 1 mu mol/L and AOPP for 1 T/L, probability for MetS rose for 1.1%, 1.4%, 11.3% and 2.2%, respectively. Adjusted R-2 for the Model was 0.531, which means that 53.1% of variation in MetS could be explained with this Model. Conclusions: Unlike XOD, MDA and AOPP, NOx is not associated with MetS.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Nitric oxide products are not associated with metabolic syndrome
VL  - 38
IS  - 3
SP  - 361
EP  - 367
DO  - 10.2478/jomb-2018-0035
ER  - 

@article{
author = "Klisić, Aleksandra and Kocić, Gordana and Kavarić, Nebojša and Pavlović, Radmila and Soldatović, Ivan and Ninić, Ana",
year = "2019",
abstract = "Background: Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. Additionally, we aimed to evaluate a broad spectrum of other oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), xanthine oxidoreductase (XOD), xanthine oxidase (XO) xanthine dehydrogenase (XDH)] in relation with MetS. Methods: A total of 109 volunteers (46.8% of them with MetS) were included in this cross-sectional study. Biohemical and anthropometric parameters, as well as blood pressure, were obtained. The MetS was diagnosed according to the International Diabetes Federation criteria. Results: Multivariate logistic regression analysis showed that XOD (OR=1.011; 95% CI 1.002-1.019; p=0.016), XO (OR=1.014; 95% CI 1.003-1.026; p=0.016), MDA (OR=1.113; 95% CI 1.038-1.192; p=0.003) and AOPP (OR=1.022; 95% CI 1.005-1.039; p=0.012) were the independent predictors of MetS, whereas no association between NOx and MetS was found. As XOD rose for 1 U/L, XO for 1 U/L, MDA for 1 mu mol/L and AOPP for 1 T/L, probability for MetS rose for 1.1%, 1.4%, 11.3% and 2.2%, respectively. Adjusted R-2 for the Model was 0.531, which means that 53.1% of variation in MetS could be explained with this Model. Conclusions: Unlike XOD, MDA and AOPP, NOx is not associated with MetS.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Nitric oxide products are not associated with metabolic syndrome",
volume = "38",
number = "3",
pages = "361-367",
doi = "10.2478/jomb-2018-0035"
}

Klisić, A., Kocić, G., Kavarić, N., Pavlović, R., Soldatović, I.,& Ninić, A.. (2019). Nitric oxide products are not associated with metabolic syndrome. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 38(3), 361-367.
https://doi.org/10.2478/jomb-2018-0035

Klisić A, Kocić G, Kavarić N, Pavlović R, Soldatović I, Ninić A. Nitric oxide products are not associated with metabolic syndrome. in Journal of Medical Biochemistry. 2019;38(3):361-367.
doi:10.2478/jomb-2018-0035 .

Klisić, Aleksandra, Kocić, Gordana, Kavarić, Nebojša, Pavlović, Radmila, Soldatović, Ivan, Ninić, Ana, "Nitric oxide products are not associated with metabolic syndrome" in Journal of Medical Biochemistry, 38, no. 3 (2019):361-367,
https://doi.org/10.2478/jomb-2018-0035 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Soldatović, Ivan
AU  - Ninić, Ana
AU  - Kotur-Stevuljević, Jelena
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3306
AB  - Background: Retinol-binding protein 4 (RBP4) and cystatin C are regarded as novel metabolic risk markers. Therefore, we aimed to examine which one of these biomarkers better correlates with metabolic syndrome (MetS) in a cohort of postmenopausal women. Methods: A total of 129 postmenopausal women (among which 62 women had MetS) were recruited in this cross-sectional study. MetS was diagnosed according to the International Diabetes Federation criteria. Results: Cystatin C and RBP4 levels were significantly higher in women with MetS, compared to those without MetS (p = 0.011 vs. p  lt 0.001, respectively). A significant difference in the proportion of women with and without MetS across cystatin C and RBP4 quartiles was observed (chi(2) = 5.1, p = 0.025, and chi(2) =11.1, p = 0.001, respectively). Logistic regression analysis revealed a borderline significant relationship between cystatin C and MetS (p = 0.066), but this significance disappeared after adjustment for age, inflammation level and duration of menopause (p = 0.221). On the contrary, a significant relationship between RBP4 and MetS was observed not only without adjustment (p = 0.009), but also even after adjustment for age, inflammation level and duration of menopause (p= 0.006). Conclusions: RBP4 better correlates with MetS than cystatin C in postmenopausal women.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Journal of Laboratory Medicine
T1  - Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C
VL  - 43
IS  - 1
SP  - 29
EP  - 34
DO  - 10.1515/labmed-2018-0325
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Soldatović, Ivan and Ninić, Ana and Kotur-Stevuljević, Jelena",
year = "2019",
abstract = "Background: Retinol-binding protein 4 (RBP4) and cystatin C are regarded as novel metabolic risk markers. Therefore, we aimed to examine which one of these biomarkers better correlates with metabolic syndrome (MetS) in a cohort of postmenopausal women. Methods: A total of 129 postmenopausal women (among which 62 women had MetS) were recruited in this cross-sectional study. MetS was diagnosed according to the International Diabetes Federation criteria. Results: Cystatin C and RBP4 levels were significantly higher in women with MetS, compared to those without MetS (p = 0.011 vs. p  lt 0.001, respectively). A significant difference in the proportion of women with and without MetS across cystatin C and RBP4 quartiles was observed (chi(2) = 5.1, p = 0.025, and chi(2) =11.1, p = 0.001, respectively). Logistic regression analysis revealed a borderline significant relationship between cystatin C and MetS (p = 0.066), but this significance disappeared after adjustment for age, inflammation level and duration of menopause (p = 0.221). On the contrary, a significant relationship between RBP4 and MetS was observed not only without adjustment (p = 0.009), but also even after adjustment for age, inflammation level and duration of menopause (p= 0.006). Conclusions: RBP4 better correlates with MetS than cystatin C in postmenopausal women.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Journal of Laboratory Medicine",
title = "Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C",
volume = "43",
number = "1",
pages = "29-34",
doi = "10.1515/labmed-2018-0325"
}

Klisić, A., Kavarić, N., Soldatović, I., Ninić, A.,& Kotur-Stevuljević, J.. (2019). Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C. in Journal of Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 43(1), 29-34.
https://doi.org/10.1515/labmed-2018-0325

Klisić A, Kavarić N, Soldatović I, Ninić A, Kotur-Stevuljević J. Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C. in Journal of Laboratory Medicine. 2019;43(1):29-34.
doi:10.1515/labmed-2018-0325 .

Klisić, Aleksandra, Kavarić, Nebojša, Soldatović, Ivan, Ninić, Ana, Kotur-Stevuljević, Jelena, "Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C" in Journal of Laboratory Medicine, 43, no. 1 (2019):29-34,
https://doi.org/10.1515/labmed-2018-0325 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Abenavoli, Ludovico
AU  - Fagoonee, Sharmila
AU  - Kavarić, Nebojša
AU  - Kocić, Gordana
AU  - Ninić, Ana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3302
AB  - BACKGROUND: It is known that non-alcoholic fatty liver disease (NAFLD), and in particular non-alcoholic steatohepatitis, can progress to advanced fibrosis. However, pathophysiological mechanisms implicated in this evolution are not elucidated yet. We aimed to investigate the independent predictors of liver fibrosis in patients with NAFLD, determined by BARD score, one of the most used algorithms for fibrosis evaluation. METHODS: This prospective study enrolled a total of 301 participants with NAFLD, as determined by a Fatty Liver Index (FLI) >= 60. All patients were categorized into two groups: with no/mild fibrosis (BARD score 1, N.=62) and with advanced fibrosis (BARD score 2, 3 and 4 N.=239). RESULTS: Serum high density lipoprotein cholesterol (HDL-c), glucose and glycated hemoglobin were higher (P=0.028, P lt 0.001 and P=0.002, respectively), whereas serum transaminases and gamma glutamil transferase levels were lower in patients with advanced fibrosis than in those with no/ mild fibrosis (P=0.010, P lt 0.001 and P=0.005, respectively). There were no significant differences in oxidative stress (i.e., advanced oxidant protein products and malondialdehyde) and anti-oxidative protection markers (i.e., catalase) between patients with no/ mild fibrosis and advanced fibrosis. Multivariate ordinal regression analysis showed independent associations and predictions of ages (OR=1.071, 95% CI 1.004-1.097, P lt 0.001), and HDL-c levels (OR= 2.549, 95% CI 1.087-5.989, P=0.032) on BARD score categories in patients with NAFLD. CONCLUSIONS: In conclusion, we found that older age and higher HDL-c, are independent predictors for advanced liver fibrosis assessed with the BARD score. Future investigations are needed to further explore this relationship.
PB  - Edizioni Minerva Medica, Turin
T2  - Minerva Medica
T1  - Older age and HDL-cholesterol as independent predictors of liver fibrosis assessed by BARD score
VL  - 110
IS  - 3
SP  - 191
EP  - 198
DO  - 10.23736/S0026-4806.19.05978-0
ER  - 

@article{
author = "Klisić, Aleksandra and Abenavoli, Ludovico and Fagoonee, Sharmila and Kavarić, Nebojša and Kocić, Gordana and Ninić, Ana",
year = "2019",
abstract = "BACKGROUND: It is known that non-alcoholic fatty liver disease (NAFLD), and in particular non-alcoholic steatohepatitis, can progress to advanced fibrosis. However, pathophysiological mechanisms implicated in this evolution are not elucidated yet. We aimed to investigate the independent predictors of liver fibrosis in patients with NAFLD, determined by BARD score, one of the most used algorithms for fibrosis evaluation. METHODS: This prospective study enrolled a total of 301 participants with NAFLD, as determined by a Fatty Liver Index (FLI) >= 60. All patients were categorized into two groups: with no/mild fibrosis (BARD score 1, N.=62) and with advanced fibrosis (BARD score 2, 3 and 4 N.=239). RESULTS: Serum high density lipoprotein cholesterol (HDL-c), glucose and glycated hemoglobin were higher (P=0.028, P lt 0.001 and P=0.002, respectively), whereas serum transaminases and gamma glutamil transferase levels were lower in patients with advanced fibrosis than in those with no/ mild fibrosis (P=0.010, P lt 0.001 and P=0.005, respectively). There were no significant differences in oxidative stress (i.e., advanced oxidant protein products and malondialdehyde) and anti-oxidative protection markers (i.e., catalase) between patients with no/ mild fibrosis and advanced fibrosis. Multivariate ordinal regression analysis showed independent associations and predictions of ages (OR=1.071, 95% CI 1.004-1.097, P lt 0.001), and HDL-c levels (OR= 2.549, 95% CI 1.087-5.989, P=0.032) on BARD score categories in patients with NAFLD. CONCLUSIONS: In conclusion, we found that older age and higher HDL-c, are independent predictors for advanced liver fibrosis assessed with the BARD score. Future investigations are needed to further explore this relationship.",
publisher = "Edizioni Minerva Medica, Turin",
journal = "Minerva Medica",
title = "Older age and HDL-cholesterol as independent predictors of liver fibrosis assessed by BARD score",
volume = "110",
number = "3",
pages = "191-198",
doi = "10.23736/S0026-4806.19.05978-0"
}

Klisić, A., Abenavoli, L., Fagoonee, S., Kavarić, N., Kocić, G.,& Ninić, A.. (2019). Older age and HDL-cholesterol as independent predictors of liver fibrosis assessed by BARD score. in Minerva Medica
Edizioni Minerva Medica, Turin., 110(3), 191-198.
https://doi.org/10.23736/S0026-4806.19.05978-0

Klisić A, Abenavoli L, Fagoonee S, Kavarić N, Kocić G, Ninić A. Older age and HDL-cholesterol as independent predictors of liver fibrosis assessed by BARD score. in Minerva Medica. 2019;110(3):191-198.
doi:10.23736/S0026-4806.19.05978-0 .

Klisić, Aleksandra, Abenavoli, Ludovico, Fagoonee, Sharmila, Kavarić, Nebojša, Kocić, Gordana, Ninić, Ana, "Older age and HDL-cholesterol as independent predictors of liver fibrosis assessed by BARD score" in Minerva Medica, 110, no. 3 (2019):191-198,
https://doi.org/10.23736/S0026-4806.19.05978-0 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Ninić, Ana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3288
AB  - Alanine-aminotransferase (ALT) and uric acid cut-off levels used in non-alcoholic fatty liver disease (NAFLD) diagnosis are advised to be lowered. Due to contradictory results on the utility of both these biomarkers for NAFLD screening, we aimed to determine their cut-off levels that can be applied to Montenegrin population with the fatty liver disease. A total of 771 volunteers were enrolled. A fatty liver index (FLI) score ≥60 was used as proxy of NAFLD. The receiver operating characteristic curve analysis with the area under the curve (AUC) was used to determine the cut-off values of ALT and uric acid associated with FLI ≥60. ALT was independent predictor of FLI in both men and women, whereas serum uric acid was its independent predictor only in women. Lower cut-off levels of ALT are associated with the increased prevalence of NAFLD [i.e., ALT was 19 IU/L (AUC=0.746, sensitivity 63%, specificity 72%, P lt 0.001) in women and 22 IU/L (AUC=0.804, sensitivity 61%, specificity 95%, P lt 0.001) in men]. The cut-off value for uric acid was 274 μmol/L (AUC=0.821, sensitivity 68%, specificity 82%, P lt 0.001) in women. Lower cut-off levels of ALT in both genders, and serum uric acid in females, can be reliable predictors of the FLI.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Predictive values of serum uric acid and Alanine-aminotransferase for fatty liver index in Montenegrin population
DO  - 10.2478/jomb-2019-0001
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Ninić, Ana",
year = "2019",
abstract = "Alanine-aminotransferase (ALT) and uric acid cut-off levels used in non-alcoholic fatty liver disease (NAFLD) diagnosis are advised to be lowered. Due to contradictory results on the utility of both these biomarkers for NAFLD screening, we aimed to determine their cut-off levels that can be applied to Montenegrin population with the fatty liver disease. A total of 771 volunteers were enrolled. A fatty liver index (FLI) score ≥60 was used as proxy of NAFLD. The receiver operating characteristic curve analysis with the area under the curve (AUC) was used to determine the cut-off values of ALT and uric acid associated with FLI ≥60. ALT was independent predictor of FLI in both men and women, whereas serum uric acid was its independent predictor only in women. Lower cut-off levels of ALT are associated with the increased prevalence of NAFLD [i.e., ALT was 19 IU/L (AUC=0.746, sensitivity 63%, specificity 72%, P lt 0.001) in women and 22 IU/L (AUC=0.804, sensitivity 61%, specificity 95%, P lt 0.001) in men]. The cut-off value for uric acid was 274 μmol/L (AUC=0.821, sensitivity 68%, specificity 82%, P lt 0.001) in women. Lower cut-off levels of ALT in both genders, and serum uric acid in females, can be reliable predictors of the FLI.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Predictive values of serum uric acid and Alanine-aminotransferase for fatty liver index in Montenegrin population",
doi = "10.2478/jomb-2019-0001"
}

Klisić, A., Kavarić, N.,& Ninić, A.. (2019). Predictive values of serum uric acid and Alanine-aminotransferase for fatty liver index in Montenegrin population. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita..
https://doi.org/10.2478/jomb-2019-0001

Klisić A, Kavarić N, Ninić A. Predictive values of serum uric acid and Alanine-aminotransferase for fatty liver index in Montenegrin population. in Journal of Medical Biochemistry. 2019;.
doi:10.2478/jomb-2019-0001 .

Klisić, Aleksandra, Kavarić, Nebojša, Ninić, Ana, "Predictive values of serum uric acid and Alanine-aminotransferase for fatty liver index in Montenegrin population" in Journal of Medical Biochemistry (2019),
https://doi.org/10.2478/jomb-2019-0001 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Bjelaković, Bojko
AU  - Jovanović, Milovan
AU  - Zvrko, Elvir
AU  - Stanišić, Verica
AU  - Ninić, Ana
AU  - Šćepanović, Anđelka
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3239
AB  - Reynolds Risk Score (RRS) is regarded as a good screening tool for cardiovascular disease (CVD) risk. Since CVD is the leading cause of death in Montenegro, we aimed to assess the risk of CVD as assessed by RRS and to examine its association with cardiometabolic parameters in apparently healthy middle-aged population. In addition, we aimed to test whether obesity had an independent influence on RRS. A total of 132 participants (mean age 56.2 +/- 6.73 years, 69% females) were included. Body mass index (BMI), waist circumference (WC), blood pressure (BP) and biochemical parameters (fasting glucose, insulin, lipid parameters, creatinine and high sensitivity C-reactive protein) were determined. Insulin resistance (HOMA-IR) and glomerular filtration rate (eGFR) were calculated. Compared with females, a significantly higher number of males were in the high RRS subgroup (chi(2) =45.9, p lt 0.001). Furthermore, significantly higher fasting glucose (p=0.030), insulin, HOMA-IR, triglycerides (p lt 0.001 all), anthropometric parameters (e.g., BMI and WC; p=0.004 and p lt 0.001, respectively), and creatinine, but lower eGFR and HDL-c (p lt 0.001 both) were recorded in the high-risk subgroup compared with low and medium risk subgroups. In all participants, in addition to LDL-c, diastolic BP and creatinine, WC was independently positively associated with RRS (beta=0.194, p=0.006; lt b> beta=0186, p=0.001; beta=0167, p=0.001; and beta=0.305, p=0.019, respectively), and 40% of variation in RRS could be explained with this model. In conclusion, middle-aged population with higher WC should be screened for RRS in order to estimate CVD risk.
PB  - Sestre Milosrdnice Univ Hospital, Zagreb
T2  - Acta Clinica Croatica
T1  - Cardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegro
VL  - 57
IS  - 1
SP  - 22
EP  - 30
DO  - 10.20471/acc.2018.57.01.03
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Bjelaković, Bojko and Jovanović, Milovan and Zvrko, Elvir and Stanišić, Verica and Ninić, Ana and Šćepanović, Anđelka",
year = "2018",
abstract = "Reynolds Risk Score (RRS) is regarded as a good screening tool for cardiovascular disease (CVD) risk. Since CVD is the leading cause of death in Montenegro, we aimed to assess the risk of CVD as assessed by RRS and to examine its association with cardiometabolic parameters in apparently healthy middle-aged population. In addition, we aimed to test whether obesity had an independent influence on RRS. A total of 132 participants (mean age 56.2 +/- 6.73 years, 69% females) were included. Body mass index (BMI), waist circumference (WC), blood pressure (BP) and biochemical parameters (fasting glucose, insulin, lipid parameters, creatinine and high sensitivity C-reactive protein) were determined. Insulin resistance (HOMA-IR) and glomerular filtration rate (eGFR) were calculated. Compared with females, a significantly higher number of males were in the high RRS subgroup (chi(2) =45.9, p lt 0.001). Furthermore, significantly higher fasting glucose (p=0.030), insulin, HOMA-IR, triglycerides (p lt 0.001 all), anthropometric parameters (e.g., BMI and WC; p=0.004 and p lt 0.001, respectively), and creatinine, but lower eGFR and HDL-c (p lt 0.001 both) were recorded in the high-risk subgroup compared with low and medium risk subgroups. In all participants, in addition to LDL-c, diastolic BP and creatinine, WC was independently positively associated with RRS (beta=0.194, p=0.006; lt b> beta=0186, p=0.001; beta=0167, p=0.001; and beta=0.305, p=0.019, respectively), and 40% of variation in RRS could be explained with this model. In conclusion, middle-aged population with higher WC should be screened for RRS in order to estimate CVD risk.",
publisher = "Sestre Milosrdnice Univ Hospital, Zagreb",
journal = "Acta Clinica Croatica",
title = "Cardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegro",
volume = "57",
number = "1",
pages = "22-30",
doi = "10.20471/acc.2018.57.01.03"
}

Klisić, A., Kavarić, N., Bjelaković, B., Jovanović, M., Zvrko, E., Stanišić, V., Ninić, A.,& Šćepanović, A.. (2018). Cardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegro. in Acta Clinica Croatica
Sestre Milosrdnice Univ Hospital, Zagreb., 57(1), 22-30.
https://doi.org/10.20471/acc.2018.57.01.03

Klisić A, Kavarić N, Bjelaković B, Jovanović M, Zvrko E, Stanišić V, Ninić A, Šćepanović A. Cardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegro. in Acta Clinica Croatica. 2018;57(1):22-30.
doi:10.20471/acc.2018.57.01.03 .

Klisić, Aleksandra, Kavarić, Nebojša, Bjelaković, Bojko, Jovanović, Milovan, Zvrko, Elvir, Stanišić, Verica, Ninić, Ana, Šćepanović, Anđelka, "Cardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegro" in Acta Clinica Croatica, 57, no. 1 (2018):22-30,
https://doi.org/10.20471/acc.2018.57.01.03 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Isaković, Aleksandra
AU  - Kocić, Gordana
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
AU  - Zvrko, Elvir
AU  - Skerović, Verica
AU  - Ninić, Ana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3233
AB  - Introduction/Aim Considering the high prevalence of nonalcoholic fatty liver disease (NAFLD) in individuals with type 2 diabetes mellitus (DM2), we aimed to investigate the potential benefit of determining markers of oxidative stress, inflammation and dyslipidemia for prediction of NAFLD, as estimated with fatty liver index (FLI) in individuals with DM2. Methods A total of 139 individuals with DM2 (of them 49.9 % females) were enrolled in cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure were obtained. A FLI was calculated. Results Multivariate logistic regression analysis showed that high density lipoprotein cholesterol (HDL-c) and malondialdehyde (MDA) were independent predictors of higher FLI [Odds ratio (OR) = 0.056, p = 0.029; and OR = 1.105, p = 0.016, respectively]. In Receiver Operating Characteristic curve analysis, the addition of fatty liver risk factors (e.g., age, gender, body height, smoking status, diabetes duration and drugs metabolized in liver) to each analysed biochemical parameter [HDL-c, non-HDL-c, high sensitivity C-reactive protein (hsCRP), MDA and advanced oxidant protein products (AOPP)] in Model 1, increased the ability to discriminate patients with and without fatty liver [Area under the curve (AUC) = 0.832, AUC = 0.808, AUC = 0.798, AUC = 0.824 and AUC = 0.743, respectively]. Model 2 (which included all five examined predictors, e.g., HDL-c, non-HDL-c, hsCRP, MDA, AOPP, and fatty liver risk factors) improved discriminative abilities for fatty liver status (AUC = 0.909). Even more, Model 2 had the highest sensitivity and specificity (89.3 % and 87.5 %, respectively) together than each predictor in Model 1. Conclusion Multimarker approach, including biomarkers of oxidative stress, dyslipidemia and inflammation, could be of benefit in identifying patients with diabetes being at high risk of fatty liver disease.
PB  - Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, Stuttgart
T2  - Experimental and Clinical Endocrinology & Diabetes
T1  - Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus
VL  - 126
IS  - 6
SP  - 371
EP  - 378
DO  - 10.1055/s-0043-118667
ER  - 

@article{
author = "Klisić, Aleksandra and Isaković, Aleksandra and Kocić, Gordana and Kavarić, Nebojša and Jovanović, Milovan and Zvrko, Elvir and Skerović, Verica and Ninić, Ana",
year = "2018",
abstract = "Introduction/Aim Considering the high prevalence of nonalcoholic fatty liver disease (NAFLD) in individuals with type 2 diabetes mellitus (DM2), we aimed to investigate the potential benefit of determining markers of oxidative stress, inflammation and dyslipidemia for prediction of NAFLD, as estimated with fatty liver index (FLI) in individuals with DM2. Methods A total of 139 individuals with DM2 (of them 49.9 % females) were enrolled in cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure were obtained. A FLI was calculated. Results Multivariate logistic regression analysis showed that high density lipoprotein cholesterol (HDL-c) and malondialdehyde (MDA) were independent predictors of higher FLI [Odds ratio (OR) = 0.056, p = 0.029; and OR = 1.105, p = 0.016, respectively]. In Receiver Operating Characteristic curve analysis, the addition of fatty liver risk factors (e.g., age, gender, body height, smoking status, diabetes duration and drugs metabolized in liver) to each analysed biochemical parameter [HDL-c, non-HDL-c, high sensitivity C-reactive protein (hsCRP), MDA and advanced oxidant protein products (AOPP)] in Model 1, increased the ability to discriminate patients with and without fatty liver [Area under the curve (AUC) = 0.832, AUC = 0.808, AUC = 0.798, AUC = 0.824 and AUC = 0.743, respectively]. Model 2 (which included all five examined predictors, e.g., HDL-c, non-HDL-c, hsCRP, MDA, AOPP, and fatty liver risk factors) improved discriminative abilities for fatty liver status (AUC = 0.909). Even more, Model 2 had the highest sensitivity and specificity (89.3 % and 87.5 %, respectively) together than each predictor in Model 1. Conclusion Multimarker approach, including biomarkers of oxidative stress, dyslipidemia and inflammation, could be of benefit in identifying patients with diabetes being at high risk of fatty liver disease.",
publisher = "Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, Stuttgart",
journal = "Experimental and Clinical Endocrinology & Diabetes",
title = "Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus",
volume = "126",
number = "6",
pages = "371-378",
doi = "10.1055/s-0043-118667"
}

Klisić, A., Isaković, A., Kocić, G., Kavarić, N., Jovanović, M., Zvrko, E., Skerović, V.,& Ninić, A.. (2018). Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus. in Experimental and Clinical Endocrinology & Diabetes
Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, Stuttgart., 126(6), 371-378.
https://doi.org/10.1055/s-0043-118667

Klisić A, Isaković A, Kocić G, Kavarić N, Jovanović M, Zvrko E, Skerović V, Ninić A. Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus. in Experimental and Clinical Endocrinology & Diabetes. 2018;126(6):371-378.
doi:10.1055/s-0043-118667 .

Klisić, Aleksandra, Isaković, Aleksandra, Kocić, Gordana, Kavarić, Nebojša, Jovanović, Milovan, Zvrko, Elvir, Skerović, Verica, Ninić, Ana, "Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus" in Experimental and Clinical Endocrinology & Diabetes, 126, no. 6 (2018):371-378,
https://doi.org/10.1055/s-0043-118667 . .

TY  - JOUR
AU  - Kavarić, Nebojša
AU  - Klisić, Aleksandra
AU  - Ninić, Ana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3175
AB  - BackgroundVisceral adiposity index (VAI) and Lipid accumulation product (LAP) are novel visceral adiposity indexes, proposed for the evaluation of cardiometabolic risk in adult population. Considering contradictory results obtained from many studies so far, we aimed to examine the potential benefit of applicability of VAI and LAP, over simple anthropometric indices and traditional lipid parameters in individuals with type 2 diabetes mellitus (DM2). MethodsA total of 180 DM2 (of them 50% females) and 119 controls who volunteered to participate in this cross-sectional study were enrolled. Anthropometric and biochemical parameters, as well as blood pressure were obtained. VAI and LAP were calculated. ResultsMultivariate logistic regression analysis showed that high-density lipoprotein cholesterol (HDL-c), (P lt .001), waist circumference (WC), (P=.027), age (P=.001), hypolipemic therapy (P=.024), and LAP (P=.005) were independent predictors of DM2 in adjusted models. In Receiver Operating Characteristic curve analysis, used to discriminate subjects with DM2 from those who did not have it, good accuracy of the applied procedures was only achieved with models which were consisted of parameters used in VAI (Body mass index, WC, HDL-c, triglycerides) and LAP (WC, triglycerides) indexes equations, respectively [Area under the curve (AUC)=0.819 and AUC=0.800, respectively], but not with VAI (AUC=0.781) and LAP (AUC=0.784) indexes themselves. ConclusionVisceral adiposity index and Lipid accumulation product may not be better than parameters that enter its equation in type 2 diabetes prediction.
PB  - Wiley, Hoboken
T2  - Journal of Clinical Laboratory Analysis
T1  - Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?
VL  - 32
IS  - 3
DO  - 10.1002/jcla.22283
ER  - 

@article{
author = "Kavarić, Nebojša and Klisić, Aleksandra and Ninić, Ana",
year = "2018",
abstract = "BackgroundVisceral adiposity index (VAI) and Lipid accumulation product (LAP) are novel visceral adiposity indexes, proposed for the evaluation of cardiometabolic risk in adult population. Considering contradictory results obtained from many studies so far, we aimed to examine the potential benefit of applicability of VAI and LAP, over simple anthropometric indices and traditional lipid parameters in individuals with type 2 diabetes mellitus (DM2). MethodsA total of 180 DM2 (of them 50% females) and 119 controls who volunteered to participate in this cross-sectional study were enrolled. Anthropometric and biochemical parameters, as well as blood pressure were obtained. VAI and LAP were calculated. ResultsMultivariate logistic regression analysis showed that high-density lipoprotein cholesterol (HDL-c), (P lt .001), waist circumference (WC), (P=.027), age (P=.001), hypolipemic therapy (P=.024), and LAP (P=.005) were independent predictors of DM2 in adjusted models. In Receiver Operating Characteristic curve analysis, used to discriminate subjects with DM2 from those who did not have it, good accuracy of the applied procedures was only achieved with models which were consisted of parameters used in VAI (Body mass index, WC, HDL-c, triglycerides) and LAP (WC, triglycerides) indexes equations, respectively [Area under the curve (AUC)=0.819 and AUC=0.800, respectively], but not with VAI (AUC=0.781) and LAP (AUC=0.784) indexes themselves. ConclusionVisceral adiposity index and Lipid accumulation product may not be better than parameters that enter its equation in type 2 diabetes prediction.",
publisher = "Wiley, Hoboken",
journal = "Journal of Clinical Laboratory Analysis",
title = "Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?",
volume = "32",
number = "3",
doi = "10.1002/jcla.22283"
}

Kavarić, N., Klisić, A.,& Ninić, A.. (2018). Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?. in Journal of Clinical Laboratory Analysis
Wiley, Hoboken., 32(3).
https://doi.org/10.1002/jcla.22283

Kavarić N, Klisić A, Ninić A. Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?. in Journal of Clinical Laboratory Analysis. 2018;32(3).
doi:10.1002/jcla.22283 .

Kavarić, Nebojša, Klisić, Aleksandra, Ninić, Ana, "Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?" in Journal of Clinical Laboratory Analysis, 32, no. 3 (2018),
https://doi.org/10.1002/jcla.22283 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kocić, Gordana
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
AU  - Stanišić, Verica
AU  - Ninić, Ana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3161
AB  - Xanthine oxidase (XO) is an important enzyme responsible for conversion of purine bases to uric acid and represents the major source of reactive oxygen species (ROS) production in circulation. Since pathophysiological mechanism of the relationship between XO activity and urinary albumin excretion (UAE) rate is not well elucidated, we aimed to investigate this association in patients with diabetes mellitus type 2 (DM2). In addition, we wanted to examine whether uric acid itself plays an independent role in albuminuria onset and progression, or it is only mediated through XO activity. A total of 83 patients with DM2 (of them 56.6% females) were included in this cross-sectional study. Anthropometric, biochemical parameters and blood pressure were obtained. Multivariate logistic regression analysis showed that uric acid and XO were the independent predictors for albuminuria onset in patients with DM2 [odds ratio (OR) 1.015, 95% CI (1.008-1.028), p = 0.026 and OR 1.015, 95% CI (1.006-1.026), p = 0.040, respectively]. Rise in uric acid for 1 mu mol/L enhanced the probability for albuminuria by 1.5%. Also, elevation in XO activity for 1 U/L increased the probability for albuminuria for 1.5%. A total of 66.7% of variation in UAE could be explained with this Model. Both XO and uric acid are independently associated with albuminuria in diabetes. Better understanding of pathophysiological relationship between oxidative stress and albuminuria could lead to discoveries of best pharmacological treatment of XO- and/or uric acid-induced ROS, in order to prevent albuminuria onset and progression.
PB  - Springer-Verlag Italia Srl, Milan
T2  - Clinical and Experimental Medicine
T1  - Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2
VL  - 18
IS  - 2
SP  - 283
EP  - 290
DO  - 10.1007/s10238-017-0483-0
ER  - 

@article{
author = "Klisić, Aleksandra and Kocić, Gordana and Kavarić, Nebojša and Jovanović, Milovan and Stanišić, Verica and Ninić, Ana",
year = "2018",
abstract = "Xanthine oxidase (XO) is an important enzyme responsible for conversion of purine bases to uric acid and represents the major source of reactive oxygen species (ROS) production in circulation. Since pathophysiological mechanism of the relationship between XO activity and urinary albumin excretion (UAE) rate is not well elucidated, we aimed to investigate this association in patients with diabetes mellitus type 2 (DM2). In addition, we wanted to examine whether uric acid itself plays an independent role in albuminuria onset and progression, or it is only mediated through XO activity. A total of 83 patients with DM2 (of them 56.6% females) were included in this cross-sectional study. Anthropometric, biochemical parameters and blood pressure were obtained. Multivariate logistic regression analysis showed that uric acid and XO were the independent predictors for albuminuria onset in patients with DM2 [odds ratio (OR) 1.015, 95% CI (1.008-1.028), p = 0.026 and OR 1.015, 95% CI (1.006-1.026), p = 0.040, respectively]. Rise in uric acid for 1 mu mol/L enhanced the probability for albuminuria by 1.5%. Also, elevation in XO activity for 1 U/L increased the probability for albuminuria for 1.5%. A total of 66.7% of variation in UAE could be explained with this Model. Both XO and uric acid are independently associated with albuminuria in diabetes. Better understanding of pathophysiological relationship between oxidative stress and albuminuria could lead to discoveries of best pharmacological treatment of XO- and/or uric acid-induced ROS, in order to prevent albuminuria onset and progression.",
publisher = "Springer-Verlag Italia Srl, Milan",
journal = "Clinical and Experimental Medicine",
title = "Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2",
volume = "18",
number = "2",
pages = "283-290",
doi = "10.1007/s10238-017-0483-0"
}

Klisić, A., Kocić, G., Kavarić, N., Jovanović, M., Stanišić, V.,& Ninić, A.. (2018). Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2. in Clinical and Experimental Medicine
Springer-Verlag Italia Srl, Milan., 18(2), 283-290.
https://doi.org/10.1007/s10238-017-0483-0

Klisić A, Kocić G, Kavarić N, Jovanović M, Stanišić V, Ninić A. Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2. in Clinical and Experimental Medicine. 2018;18(2):283-290.
doi:10.1007/s10238-017-0483-0 .

Klisić, Aleksandra, Kocić, Gordana, Kavarić, Nebojša, Jovanović, Milovan, Stanišić, Verica, Ninić, Ana, "Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2" in Clinical and Experimental Medicine, 18, no. 2 (2018):283-290,
https://doi.org/10.1007/s10238-017-0483-0 . .

TY  - JOUR
AU  - Kavarić, Nebojša
AU  - Klisić, Aleksandra
AU  - Ninić, Ana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3139
AB  - Since there is a high prevalence of type 2 diabetes mellitus (DM2), as well as CVD in Montenegro, we aimed to estimate CVD risk by United Kingdom Prospective Diabetes Study (UKPDS) risk engine algorithm in individuals with DM2. Furthermore, we aimed to explore whether non-traditional biomarker such as high sensitivity C-reactive protein (hsCRP) is superior for CVD risk prediction over old traditional risk factors. A total of 180 participants with DM2 (of them 50% females) were included in the current cross-sectional study. Biochemical and anthropometric parameters, and blood pressure were obtained. More males than females were classified at high UKPDS risk category (p lt 0.001). Also, about one third of diabetic patients (29.4%) were classified into the high-risk category. In multivariate regression analysis, triglycerides [Odds ratio (OR) =1.703, p=0.001] and creatinine concentration (OR=1.040, p lt 0.001) were independent predictors of CVD risk, whereas hsCRP was not correlated with CVD risk. HsCRP is not superior for CVD risk prediction by UKPDS risk engine algorithm over high triglyceride and creatinine levels in diabetic population, which suggests that the old traditional markers must not be underestimated when examining CVD risk in population with diabetes.
PB  - Sciendo, Warsaw
T2  - Open Medicine
T1  - Cardiovascular risk estimated by UKPDS risk engine algorithm in diabetes
VL  - 13
IS  - 1
SP  - 610
EP  - 617
DO  - 10.1515/med-2018-0086
ER  - 

@article{
author = "Kavarić, Nebojša and Klisić, Aleksandra and Ninić, Ana",
year = "2018",
abstract = "Since there is a high prevalence of type 2 diabetes mellitus (DM2), as well as CVD in Montenegro, we aimed to estimate CVD risk by United Kingdom Prospective Diabetes Study (UKPDS) risk engine algorithm in individuals with DM2. Furthermore, we aimed to explore whether non-traditional biomarker such as high sensitivity C-reactive protein (hsCRP) is superior for CVD risk prediction over old traditional risk factors. A total of 180 participants with DM2 (of them 50% females) were included in the current cross-sectional study. Biochemical and anthropometric parameters, and blood pressure were obtained. More males than females were classified at high UKPDS risk category (p lt 0.001). Also, about one third of diabetic patients (29.4%) were classified into the high-risk category. In multivariate regression analysis, triglycerides [Odds ratio (OR) =1.703, p=0.001] and creatinine concentration (OR=1.040, p lt 0.001) were independent predictors of CVD risk, whereas hsCRP was not correlated with CVD risk. HsCRP is not superior for CVD risk prediction by UKPDS risk engine algorithm over high triglyceride and creatinine levels in diabetic population, which suggests that the old traditional markers must not be underestimated when examining CVD risk in population with diabetes.",
publisher = "Sciendo, Warsaw",
journal = "Open Medicine",
title = "Cardiovascular risk estimated by UKPDS risk engine algorithm in diabetes",
volume = "13",
number = "1",
pages = "610-617",
doi = "10.1515/med-2018-0086"
}

Kavarić, N., Klisić, A.,& Ninić, A.. (2018). Cardiovascular risk estimated by UKPDS risk engine algorithm in diabetes. in Open Medicine
Sciendo, Warsaw., 13(1), 610-617.
https://doi.org/10.1515/med-2018-0086

Kavarić N, Klisić A, Ninić A. Cardiovascular risk estimated by UKPDS risk engine algorithm in diabetes. in Open Medicine. 2018;13(1):610-617.
doi:10.1515/med-2018-0086 .

Kavarić, Nebojša, Klisić, Aleksandra, Ninić, Ana, "Cardiovascular risk estimated by UKPDS risk engine algorithm in diabetes" in Open Medicine, 13, no. 1 (2018):610-617,
https://doi.org/10.1515/med-2018-0086 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Bjelaković, Bojko
AU  - Zvrko, Elvir
AU  - Soldatović, Ivan
AU  - Kotur-Stevuljević, Jelena
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3120
AB  - Objective: Better than simple anthropometric parameters, the visceral adiposity index (VAI) has recently been proposed as a predictor of cardiometabolic risk in adults. However, there are conflicting results on the associations of these parameters in children and adolescents. Therefore, we aimed to estimate this potential relationship between VAI, anthropometric parameters (i.e., body mass index [BMI], waist circumference [WC], and waist-to-height ratio [WHtR], respectively), and inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) levels in a cohort of adolescent girls. Methods: A total of 90 adolescent girls from 16 to 19 years old were included in cross-sectional study. Anthropometric and biochemical parameters (glucose, lipid parameters, and hsCRP) were measured. The VAI, derived from anthropometric and lipid parameters, calculated {[WC/36.58 + (1.89 x BMI)] x (triglycerides/0.81) x (1.52/ HDL-cholesterol)} was calculated. Results: A comparison of the receiver operating characteristic (ROC) curves showed that all the curves for the anthropometric parameters (e.g., BMI, WC, WHtR) had excellent discriminatory capability with regard to inflammation level status (low vs. high level) and significantly larger areas under the curve (AUC = 0.885, AUC = 0.863, AUC = 0.860, respectively; P lt 0.001) than the ROC curve for VAI did (AUC = 0.686; P = 0.021). Conclusion: Visceral adiposity index is not superior over anthropometric parameters in relation to inflammation as measured by high sensitivity C-reactive protein in adolescent girls.
PB  - Univ Puerto Rico Medical Sciences Campus, San Juan
T2  - Puerto Rico Health Sciences Journal
T1  - Visceral Adiposity Index is not Superior over Anthropometric Parameters with regards to Inflammation in Healthy Adolescent Girls
VL  - 37
IS  - 4
SP  - 195
EP  - 199
UR  - https://hdl.handle.net/21.15107/rcub_farfar_3120
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Bjelaković, Bojko and Zvrko, Elvir and Soldatović, Ivan and Kotur-Stevuljević, Jelena",
year = "2018",
abstract = "Objective: Better than simple anthropometric parameters, the visceral adiposity index (VAI) has recently been proposed as a predictor of cardiometabolic risk in adults. However, there are conflicting results on the associations of these parameters in children and adolescents. Therefore, we aimed to estimate this potential relationship between VAI, anthropometric parameters (i.e., body mass index [BMI], waist circumference [WC], and waist-to-height ratio [WHtR], respectively), and inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) levels in a cohort of adolescent girls. Methods: A total of 90 adolescent girls from 16 to 19 years old were included in cross-sectional study. Anthropometric and biochemical parameters (glucose, lipid parameters, and hsCRP) were measured. The VAI, derived from anthropometric and lipid parameters, calculated {[WC/36.58 + (1.89 x BMI)] x (triglycerides/0.81) x (1.52/ HDL-cholesterol)} was calculated. Results: A comparison of the receiver operating characteristic (ROC) curves showed that all the curves for the anthropometric parameters (e.g., BMI, WC, WHtR) had excellent discriminatory capability with regard to inflammation level status (low vs. high level) and significantly larger areas under the curve (AUC = 0.885, AUC = 0.863, AUC = 0.860, respectively; P lt 0.001) than the ROC curve for VAI did (AUC = 0.686; P = 0.021). Conclusion: Visceral adiposity index is not superior over anthropometric parameters in relation to inflammation as measured by high sensitivity C-reactive protein in adolescent girls.",
publisher = "Univ Puerto Rico Medical Sciences Campus, San Juan",
journal = "Puerto Rico Health Sciences Journal",
title = "Visceral Adiposity Index is not Superior over Anthropometric Parameters with regards to Inflammation in Healthy Adolescent Girls",
volume = "37",
number = "4",
pages = "195-199",
url = "https://hdl.handle.net/21.15107/rcub_farfar_3120"
}

Klisić, A., Kavarić, N., Bjelaković, B., Zvrko, E., Soldatović, I.,& Kotur-Stevuljević, J.. (2018). Visceral Adiposity Index is not Superior over Anthropometric Parameters with regards to Inflammation in Healthy Adolescent Girls. in Puerto Rico Health Sciences Journal
Univ Puerto Rico Medical Sciences Campus, San Juan., 37(4), 195-199.
https://hdl.handle.net/21.15107/rcub_farfar_3120

Klisić A, Kavarić N, Bjelaković B, Zvrko E, Soldatović I, Kotur-Stevuljević J. Visceral Adiposity Index is not Superior over Anthropometric Parameters with regards to Inflammation in Healthy Adolescent Girls. in Puerto Rico Health Sciences Journal. 2018;37(4):195-199.
https://hdl.handle.net/21.15107/rcub_farfar_3120 .

Klisić, Aleksandra, Kavarić, Nebojša, Bjelaković, Bojko, Zvrko, Elvir, Soldatović, Ivan, Kotur-Stevuljević, Jelena, "Visceral Adiposity Index is not Superior over Anthropometric Parameters with regards to Inflammation in Healthy Adolescent Girls" in Puerto Rico Health Sciences Journal, 37, no. 4 (2018):195-199,
https://hdl.handle.net/21.15107/rcub_farfar_3120 .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Ninić, Ana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3082
AB  - Background:Since the increase in some tubular damage biomarkers can be observed at the early stage of diabetic nephropathy, even in the absence of albuminuria, we aimed to investigate if urinary albumin is superior than tubular damage marker, such as serum retinol-binding protein 4 (RBP4), in predicting renal function decline (defined as estimated glomerular filtration rate [eGFR]  lt 60 mL/min/1.73 m(2)) in the cohort of patients with type 2 diabetes mellitus (T2D).MATERIALS AND Methods:A total of 106 sedentary T2D patients (mean [+/- standard deviation] age 64.9 [+/- 6.6] years) were included in this cross-sectional study. Anthropometric and biochemical parameters (fasting glucose, glycated hemoglobin [HbA1c], lipid parameters, creatinine, RBP4, high sensitivity C-reactive protein [hsCRP], urinary albumin excretion [UAE]), as well as blood pressure were obtained.Results:HsCRP (odds ratio [OR] =0.754, 95% confidence interval [CI] (0.603-0.942), P = 0.013) and RBP4 (OR = 0.873, 95% CI [0.824-0.926], P  lt  0.001) were independent predictors of eGFR decline. Moreover, although RBP4 and UAE as single diagnostic parameters of renal impairment showed excellent clinical accuracy (area under the curve [AUC] = 0.900 and AUC = 0.940, respectively), the Model which included body mass index, HbA1c, triglycerides, hsCRP, and RBP4 showed statistically same accuracy as UAE, when UAE was used as a single parameter (AUC = 0.932 vs. AUC = 0.940, respectively; P for AUC difference = 0.759). As well, the Model had higher sensitivity and specificity (92% and 90%, respectively) than single predictors, RBP4, and UAE.Conclusion:Although serum RBP4 showed excellent clinical accuracy, just like UAE, a combination of markers of tubular damage, inflammation, and traditional markers has the higher sensitivity and specificity than UAE alone for prediction renal impairment in patients with T2D.
PB  - Wolters Kluwer Medknow Publications, Mumbai
T2  - Journal of Research in Medical Sciences
T1  - Retinol-binding protein 4 versus albuminuria as predictors of estimated glomerular filtration rate decline in patients with type 2 diabetes
VL  - 23
DO  - 10.4103/jrms.JRMS_893_17
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Ninić, Ana",
year = "2018",
abstract = "Background:Since the increase in some tubular damage biomarkers can be observed at the early stage of diabetic nephropathy, even in the absence of albuminuria, we aimed to investigate if urinary albumin is superior than tubular damage marker, such as serum retinol-binding protein 4 (RBP4), in predicting renal function decline (defined as estimated glomerular filtration rate [eGFR]  lt 60 mL/min/1.73 m(2)) in the cohort of patients with type 2 diabetes mellitus (T2D).MATERIALS AND Methods:A total of 106 sedentary T2D patients (mean [+/- standard deviation] age 64.9 [+/- 6.6] years) were included in this cross-sectional study. Anthropometric and biochemical parameters (fasting glucose, glycated hemoglobin [HbA1c], lipid parameters, creatinine, RBP4, high sensitivity C-reactive protein [hsCRP], urinary albumin excretion [UAE]), as well as blood pressure were obtained.Results:HsCRP (odds ratio [OR] =0.754, 95% confidence interval [CI] (0.603-0.942), P = 0.013) and RBP4 (OR = 0.873, 95% CI [0.824-0.926], P  lt  0.001) were independent predictors of eGFR decline. Moreover, although RBP4 and UAE as single diagnostic parameters of renal impairment showed excellent clinical accuracy (area under the curve [AUC] = 0.900 and AUC = 0.940, respectively), the Model which included body mass index, HbA1c, triglycerides, hsCRP, and RBP4 showed statistically same accuracy as UAE, when UAE was used as a single parameter (AUC = 0.932 vs. AUC = 0.940, respectively; P for AUC difference = 0.759). As well, the Model had higher sensitivity and specificity (92% and 90%, respectively) than single predictors, RBP4, and UAE.Conclusion:Although serum RBP4 showed excellent clinical accuracy, just like UAE, a combination of markers of tubular damage, inflammation, and traditional markers has the higher sensitivity and specificity than UAE alone for prediction renal impairment in patients with T2D.",
publisher = "Wolters Kluwer Medknow Publications, Mumbai",
journal = "Journal of Research in Medical Sciences",
title = "Retinol-binding protein 4 versus albuminuria as predictors of estimated glomerular filtration rate decline in patients with type 2 diabetes",
volume = "23",
doi = "10.4103/jrms.JRMS_893_17"
}

Klisić, A., Kavarić, N.,& Ninić, A.. (2018). Retinol-binding protein 4 versus albuminuria as predictors of estimated glomerular filtration rate decline in patients with type 2 diabetes. in Journal of Research in Medical Sciences
Wolters Kluwer Medknow Publications, Mumbai., 23.
https://doi.org/10.4103/jrms.JRMS_893_17

Klisić A, Kavarić N, Ninić A. Retinol-binding protein 4 versus albuminuria as predictors of estimated glomerular filtration rate decline in patients with type 2 diabetes. in Journal of Research in Medical Sciences. 2018;23.
doi:10.4103/jrms.JRMS_893_17 .

Klisić, Aleksandra, Kavarić, Nebojša, Ninić, Ana, "Retinol-binding protein 4 versus albuminuria as predictors of estimated glomerular filtration rate decline in patients with type 2 diabetes" in Journal of Research in Medical Sciences, 23 (2018),
https://doi.org/10.4103/jrms.JRMS_893_17 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Kavarić, Nebojša
AU  - Martinović, Milica
AU  - Matić, Marija
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3039
AB  - Purpose Menopause is frequently associated with an increase in visceral fat, thus modifying redox status by promoting oxidative damage and decreasing antioxidant defense systems. It is known that at higher concentrations estradiol has some antioxidant properties, while its decline in postmenopause is associated with pro-oxidant effects. However, the role of follicle stimulating hormone (FSH) in antioxidant defense in postmenopausal women is still not well elucidated. Therefore, we aimed to evaluate the potential complex association between visceral obesity, FSH and enzymatic antioxidant defense as measured by glutathione peroxidase (GPx) in postmenopausal women. Methods A total of 150 postmenopausal women (mean age 56.6 +/- 4.8 years), among them 50 normal weight and 100 overweight/obese, were included. GPx activity, FSH, luteinizing hormone, estradiol, total testosterone, cardiometabolic and anthropometric parameters, were determined. Results With increasing tertiles of serum FSH levels, significant increase in GPx activity (P = 0.005) was found. Also, the highest number of overweight/obese subjects were in the group with the lowest FSH values (chi(2) = 14.9, P  lt  0.001). After multiple linear regression analysis, the relationship between GPx and FSH disappeared, whereas only higher waist circumference (beta = -0.218, P = 0.045) predicted lower FSH level (adjusted R-2 = 0.227). Conclusion Higher GPx activity is associated with higher FSH level, but abdominal obesity may be the underlying determinant of this relationship.
PB  - Springer, New York
T2  - Eating and Weight Disorders
T1  - The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women
VL  - 23
IS  - 1
SP  - 133
EP  - 141
DO  - 10.1007/s40519-016-0325-1
ER  - 

@article{
author = "Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Kavarić, Nebojša and Martinović, Milica and Matić, Marija",
year = "2018",
abstract = "Purpose Menopause is frequently associated with an increase in visceral fat, thus modifying redox status by promoting oxidative damage and decreasing antioxidant defense systems. It is known that at higher concentrations estradiol has some antioxidant properties, while its decline in postmenopause is associated with pro-oxidant effects. However, the role of follicle stimulating hormone (FSH) in antioxidant defense in postmenopausal women is still not well elucidated. Therefore, we aimed to evaluate the potential complex association between visceral obesity, FSH and enzymatic antioxidant defense as measured by glutathione peroxidase (GPx) in postmenopausal women. Methods A total of 150 postmenopausal women (mean age 56.6 +/- 4.8 years), among them 50 normal weight and 100 overweight/obese, were included. GPx activity, FSH, luteinizing hormone, estradiol, total testosterone, cardiometabolic and anthropometric parameters, were determined. Results With increasing tertiles of serum FSH levels, significant increase in GPx activity (P = 0.005) was found. Also, the highest number of overweight/obese subjects were in the group with the lowest FSH values (chi(2) = 14.9, P  lt  0.001). After multiple linear regression analysis, the relationship between GPx and FSH disappeared, whereas only higher waist circumference (beta = -0.218, P = 0.045) predicted lower FSH level (adjusted R-2 = 0.227). Conclusion Higher GPx activity is associated with higher FSH level, but abdominal obesity may be the underlying determinant of this relationship.",
publisher = "Springer, New York",
journal = "Eating and Weight Disorders",
title = "The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women",
volume = "23",
number = "1",
pages = "133-141",
doi = "10.1007/s40519-016-0325-1"
}

Klisić, A., Kotur-Stevuljević, J., Kavarić, N., Martinović, M.,& Matić, M.. (2018). The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women. in Eating and Weight Disorders
Springer, New York., 23(1), 133-141.
https://doi.org/10.1007/s40519-016-0325-1

Klisić A, Kotur-Stevuljević J, Kavarić N, Martinović M, Matić M. The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women. in Eating and Weight Disorders. 2018;23(1):133-141.
doi:10.1007/s40519-016-0325-1 .

Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Kavarić, Nebojša, Martinović, Milica, Matić, Marija, "The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women" in Eating and Weight Disorders, 23, no. 1 (2018):133-141,
https://doi.org/10.1007/s40519-016-0325-1 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Bjelaković, Bojko
AU  - Soldatović, Ivan
AU  - Martinović, Milica
AU  - Kotur-Stevuljević, Jelena
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3017
AB  - Retinol-binding protein 4 (RBP4) is an emerging risk factor for atherosclerotic disease in adults. However, to our knowledge, there are no studies examining the relationship between RBP4 and cardiovascular risk in young population. Therefore, we aimed to estimate this potential relationship in overweight/obese adolescent girls. Seventy overweight/obese adolescent girls, mean age 17.6 +/- 1.20 years, were included. Anthropometric and biochemical parameters were measured. Cardiovascular risk score (CVRS) was calculated by adding points for each risk factor (e.g., sex, high-density lipoprotein cholesterol (HDL-c), non-HDL-c, smoking, blood pressure and fasting glycemia). According to the risk status, we divided adolescent girls into low, medium and high risk groups (-2  lt = CVRS  lt = 1, 2  lt = CVRS 54 and CVRS >= 5, respectively). We found significantly higher RBP4 in the high risk group as compared with low risk group (p lt 0.001). However, multiple linear regression analysis showed waist circumference (beta=0.257, p=0.031) to be the only independent predictor of higher cardiovascular risk (adjusted R'=0.342, p lt 0.001). In conclusion, RBP4 may be associated with higher cardiovascular risk in overweight/obese adolescent girls, but this association is mediated by abdominal obesity.
PB  - Sestre Milosrdnice Univ Hospital, Zagreb
T2  - Acta Clinica Croatica
T1  - The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls
VL  - 56
IS  - 1
SP  - 92
EP  - 98
DO  - 10.20471/acc.2017.56.01.14
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Bjelaković, Bojko and Soldatović, Ivan and Martinović, Milica and Kotur-Stevuljević, Jelena",
year = "2017",
abstract = "Retinol-binding protein 4 (RBP4) is an emerging risk factor for atherosclerotic disease in adults. However, to our knowledge, there are no studies examining the relationship between RBP4 and cardiovascular risk in young population. Therefore, we aimed to estimate this potential relationship in overweight/obese adolescent girls. Seventy overweight/obese adolescent girls, mean age 17.6 +/- 1.20 years, were included. Anthropometric and biochemical parameters were measured. Cardiovascular risk score (CVRS) was calculated by adding points for each risk factor (e.g., sex, high-density lipoprotein cholesterol (HDL-c), non-HDL-c, smoking, blood pressure and fasting glycemia). According to the risk status, we divided adolescent girls into low, medium and high risk groups (-2  lt = CVRS  lt = 1, 2  lt = CVRS 54 and CVRS >= 5, respectively). We found significantly higher RBP4 in the high risk group as compared with low risk group (p lt 0.001). However, multiple linear regression analysis showed waist circumference (beta=0.257, p=0.031) to be the only independent predictor of higher cardiovascular risk (adjusted R'=0.342, p lt 0.001). In conclusion, RBP4 may be associated with higher cardiovascular risk in overweight/obese adolescent girls, but this association is mediated by abdominal obesity.",
publisher = "Sestre Milosrdnice Univ Hospital, Zagreb",
journal = "Acta Clinica Croatica",
title = "The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls",
volume = "56",
number = "1",
pages = "92-98",
doi = "10.20471/acc.2017.56.01.14"
}

Klisić, A., Kavarić, N., Bjelaković, B., Soldatović, I., Martinović, M.,& Kotur-Stevuljević, J.. (2017). The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls. in Acta Clinica Croatica
Sestre Milosrdnice Univ Hospital, Zagreb., 56(1), 92-98.
https://doi.org/10.20471/acc.2017.56.01.14

Klisić A, Kavarić N, Bjelaković B, Soldatović I, Martinović M, Kotur-Stevuljević J. The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls. in Acta Clinica Croatica. 2017;56(1):92-98.
doi:10.20471/acc.2017.56.01.14 .

Klisić, Aleksandra, Kavarić, Nebojša, Bjelaković, Bojko, Soldatović, Ivan, Martinović, Milica, Kotur-Stevuljević, Jelena, "The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls" in Acta Clinica Croatica, 56, no. 1 (2017):92-98,
https://doi.org/10.20471/acc.2017.56.01.14 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Stanišić, Verica
AU  - Jovanović, Milovan
AU  - Kavarić, Nebojša
AU  - Ninić, Ana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2973
AB  - Aim: Retinol-binding protein 4 (RBP4) is a novel adipokine closely related to insulin resistance. However, data on the influence of menopausal status on serum RBP4 are scarce. Therefore, the aim of the current study was to examine whether RBP4 levels are associated with menopausal status per se, independently of insulin resistance. Methods: A total of 30 premenopausal and 100 postmenopausal women non-treated with medications were included in the cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure (BP) were obtained. The homeostasis model assessment of insulin resistance (HOMA-IR) and estimated glomerular filtration rate (eGFR) were calculated. Results: Postmenopausal women displayed higher RBP4 and an unfavorable cardiometabolic profile, compared to premenopausal ones. Multiple linear regression analysis showed that in addition to high triglycerides level (beta=0.315; p=0.002), decreased eGFR (beta=-0.258; p=0.004) and high systolic BP (beta=0.418; p=0.028), menopause per se is an independent predictor of higher RBP4 levels (beta=0.240; p=0.016), (R2-adjusted=0.310; F=6,522; p lt 0.001). Conclusions: Serum RBP4 levels are dependent of menopausal status, which should be taken into account when examining the role of this adipokine in cardiometabolic diseases' occurrence.
AB  - Cilj: Retinol-vezujući protein 4 (RBP4) je novi adipokin, usko povezan sa insulinskom rezistencijom. Međutim, nema dovoljno podataka u literaturi o uticaju menopauze na vrednosti ovog proteina u serumu. Zato je cilj ove studije bio da se ispita da li je povezanost menopauze i RBP4 nezavisna ili je posredovana insulinskom rezistencijom. Metode: Ukupno 30 žena u premenopauzi i 100 žena u postmenopauzi, koje nisu na terapiji su uključene u studiju preseka. Mereni su antropometrijski i biohemijski parametri, kao i krvni pritisak (KP), HOMA indeksi, procenjena jačina glomerularne filtracije (JGF) i izračunati su. Rezultati: Kod žena u postmenopauzi zabeležene su veće vrednosti RBP4 i nepovoljniji kardiometabolički profil, u poređenju sa ženama u premenopauzi. Višestruka linearnaregresiona analiza je pokazala da su više vrednosti triglicerida (beta=0,315; p=0,002), smanjena JGF (beta=-0,258; p=0,004), više vrednosti sistolnog KP (beta=0,418; p=0,028), i menopauza (beta=0,240; p=0,016), nezavisni prediktori povišenih vrednosti RBP4 u serumu (R2-adjusted=0,310; F=6,522; p lt 0,001). Zaključak: Menopauza utiče na vrednosti RBP4 u serumu, što treba uzeti u obzir prilikom ispitivanja uloge ovog adipokina u pojavi kardiometaboličkih poremećaja.
PB  - Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar
T2  - Timočki medicinski glasnik
T1  - Menopausal status as an independent predictor of high serum retinol-binding protein 4 levels
T1  - Menopauza kao nezavisni prediktor povišenih vrednosti retinolvezujućeg proteina 4 u serumu
VL  - 42
IS  - 4
SP  - 199
EP  - 205
DO  - 10.5937/tmg1704199K
ER  - 

@article{
author = "Klisić, Aleksandra and Stanišić, Verica and Jovanović, Milovan and Kavarić, Nebojša and Ninić, Ana",
year = "2017",
abstract = "Aim: Retinol-binding protein 4 (RBP4) is a novel adipokine closely related to insulin resistance. However, data on the influence of menopausal status on serum RBP4 are scarce. Therefore, the aim of the current study was to examine whether RBP4 levels are associated with menopausal status per se, independently of insulin resistance. Methods: A total of 30 premenopausal and 100 postmenopausal women non-treated with medications were included in the cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure (BP) were obtained. The homeostasis model assessment of insulin resistance (HOMA-IR) and estimated glomerular filtration rate (eGFR) were calculated. Results: Postmenopausal women displayed higher RBP4 and an unfavorable cardiometabolic profile, compared to premenopausal ones. Multiple linear regression analysis showed that in addition to high triglycerides level (beta=0.315; p=0.002), decreased eGFR (beta=-0.258; p=0.004) and high systolic BP (beta=0.418; p=0.028), menopause per se is an independent predictor of higher RBP4 levels (beta=0.240; p=0.016), (R2-adjusted=0.310; F=6,522; p lt 0.001). Conclusions: Serum RBP4 levels are dependent of menopausal status, which should be taken into account when examining the role of this adipokine in cardiometabolic diseases' occurrence., Cilj: Retinol-vezujući protein 4 (RBP4) je novi adipokin, usko povezan sa insulinskom rezistencijom. Međutim, nema dovoljno podataka u literaturi o uticaju menopauze na vrednosti ovog proteina u serumu. Zato je cilj ove studije bio da se ispita da li je povezanost menopauze i RBP4 nezavisna ili je posredovana insulinskom rezistencijom. Metode: Ukupno 30 žena u premenopauzi i 100 žena u postmenopauzi, koje nisu na terapiji su uključene u studiju preseka. Mereni su antropometrijski i biohemijski parametri, kao i krvni pritisak (KP), HOMA indeksi, procenjena jačina glomerularne filtracije (JGF) i izračunati su. Rezultati: Kod žena u postmenopauzi zabeležene su veće vrednosti RBP4 i nepovoljniji kardiometabolički profil, u poređenju sa ženama u premenopauzi. Višestruka linearnaregresiona analiza je pokazala da su više vrednosti triglicerida (beta=0,315; p=0,002), smanjena JGF (beta=-0,258; p=0,004), više vrednosti sistolnog KP (beta=0,418; p=0,028), i menopauza (beta=0,240; p=0,016), nezavisni prediktori povišenih vrednosti RBP4 u serumu (R2-adjusted=0,310; F=6,522; p lt 0,001). Zaključak: Menopauza utiče na vrednosti RBP4 u serumu, što treba uzeti u obzir prilikom ispitivanja uloge ovog adipokina u pojavi kardiometaboličkih poremećaja.",
publisher = "Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar",
journal = "Timočki medicinski glasnik",
title = "Menopausal status as an independent predictor of high serum retinol-binding protein 4 levels, Menopauza kao nezavisni prediktor povišenih vrednosti retinolvezujućeg proteina 4 u serumu",
volume = "42",
number = "4",
pages = "199-205",
doi = "10.5937/tmg1704199K"
}

Klisić, A., Stanišić, V., Jovanović, M., Kavarić, N.,& Ninić, A.. (2017). Menopausal status as an independent predictor of high serum retinol-binding protein 4 levels. in Timočki medicinski glasnik
Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar., 42(4), 199-205.
https://doi.org/10.5937/tmg1704199K

Klisić A, Stanišić V, Jovanović M, Kavarić N, Ninić A. Menopausal status as an independent predictor of high serum retinol-binding protein 4 levels. in Timočki medicinski glasnik. 2017;42(4):199-205.
doi:10.5937/tmg1704199K .

Klisić, Aleksandra, Stanišić, Verica, Jovanović, Milovan, Kavarić, Nebojša, Ninić, Ana, "Menopausal status as an independent predictor of high serum retinol-binding protein 4 levels" in Timočki medicinski glasnik, 42, no. 4 (2017):199-205,
https://doi.org/10.5937/tmg1704199K . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Stanišić, Verica
AU  - Jovanović, Milovan
AU  - Kavarić, Nebojša
AU  - Ninić, Ana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2914
AB  - Aim: Although previous studies confirmed the association between obesity and hypertension, the underlying pathophysiological mechanism is not well elucidated, specially considering the fact that discordant results exist when examining the independent role of obesity and/or insulin resistance on risk for hypertension onset. Therefore, we aimed to examine if obesity [as measured with body mass index (BMI)] is a predictor for hypertension, independently of insulin resistance [as measured with Homeostasis model assessment of insulin resistance (HOMA-IR)] in the cohort of postmenopausal women. Methods: A total of 150 postmenopausal women non-treated with medications(among them 44.7% hypertensive)were included in cross-sectional study. Anthropometric and biochemical parameters, so as blood pressure were obtained. HOMA-IR was calculated. Results: Multivariate logistic regression analysisrevealed that both, BMI and HOMA-IR were the independent predictors of blood pressure in postmenopausal women (OR=1.240, p=0.035 and OR=2.419, p=0.008, respectively). Rise in BMI for 1 kg/m2 enhanced the probability for higher blood pressure by 24%. Also, elevation in HOMA-IR for 1 unit, rose the probability for higher blood pressure almost 2.5 times. Even 47% of variation in blood pressure could be explained with this Model. Also, this Model correctly classified 76% of postmenopausal women having hypertension. Conclusions: Both, obesity and insulin resistance are the independent predictors of blood pressure in postmenopausal women.
AB  - Cilj: Premda su ranije studije potvrdile vezu između gojaznosti i hipertenzije, patofiziološki mehanizam ove povezanosti još uvek nije rasvetljen, naročito što postoje oprečni rezultati kada je u pitanju nezavisna uloga gojaznosti i/ili insulinske rezistencije u nastanku hipertenzije. Stoga je cilj studije bio da se ispita da li je gojaznost [merena indeksom telesne mase (ITM)] prediktor za nastanak hipertenzije, nezavisno od insulinske rezistencije [merene HOMA indeksom (HOMA-IR)] u kohorti žena u postmenopauzi. Metode: Ukupno 150 žena u postmenopauzi koje nisu na terapiji (među njima 44,7% sa hipertenzijom) su uključene u studiju preseka. Antropometrijski i biohemijski parametri, kao i krvni pritisak su mereni. HOMA-IR je računat. Rezultati: Multivarijantna logistička regresiona analiza je pokazala da su i ITM (OR=1,240; p=0,035) i HOMA-IR (OR=2,419; p=0,008)nezavisni prediktori krvnog pritiska kod žena u postmenopauzi. Povećanje ITMza1 kg/m2 povećava verovatnoću za pojavu hipertenzije za 24%. Takođe, porast HOMA-IR za 1 jedinicu povećava verovatnoću za pojavu hipertenzije za skoro 2,5 puta. Čak 47% varijacije u vrednosti krvnog pritiska može biti objašnjeno ovim modelom. Takođe, ovaj model je ispravno klasifikovao 76% žena u postmenopauzi koje imaju hipertenziju. Zaključak: I gojaznost, i insulinska rezistencija su nezavisni prediktori krvnog pritiska kod žena u postmenopauzi.
PB  - Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar
T2  - Timočki medicinski glasnik
T1  - Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women
T1  - Indeks telesne mase i insulinska rezistencija kao nezavisni prediktori hipertenzije kod žena u postmenopauzi
VL  - 42
IS  - 3
SP  - 165
EP  - 172
DO  - 10.5937/tmg1703165K
ER  - 

@article{
author = "Klisić, Aleksandra and Stanišić, Verica and Jovanović, Milovan and Kavarić, Nebojša and Ninić, Ana",
year = "2017",
abstract = "Aim: Although previous studies confirmed the association between obesity and hypertension, the underlying pathophysiological mechanism is not well elucidated, specially considering the fact that discordant results exist when examining the independent role of obesity and/or insulin resistance on risk for hypertension onset. Therefore, we aimed to examine if obesity [as measured with body mass index (BMI)] is a predictor for hypertension, independently of insulin resistance [as measured with Homeostasis model assessment of insulin resistance (HOMA-IR)] in the cohort of postmenopausal women. Methods: A total of 150 postmenopausal women non-treated with medications(among them 44.7% hypertensive)were included in cross-sectional study. Anthropometric and biochemical parameters, so as blood pressure were obtained. HOMA-IR was calculated. Results: Multivariate logistic regression analysisrevealed that both, BMI and HOMA-IR were the independent predictors of blood pressure in postmenopausal women (OR=1.240, p=0.035 and OR=2.419, p=0.008, respectively). Rise in BMI for 1 kg/m2 enhanced the probability for higher blood pressure by 24%. Also, elevation in HOMA-IR for 1 unit, rose the probability for higher blood pressure almost 2.5 times. Even 47% of variation in blood pressure could be explained with this Model. Also, this Model correctly classified 76% of postmenopausal women having hypertension. Conclusions: Both, obesity and insulin resistance are the independent predictors of blood pressure in postmenopausal women., Cilj: Premda su ranije studije potvrdile vezu između gojaznosti i hipertenzije, patofiziološki mehanizam ove povezanosti još uvek nije rasvetljen, naročito što postoje oprečni rezultati kada je u pitanju nezavisna uloga gojaznosti i/ili insulinske rezistencije u nastanku hipertenzije. Stoga je cilj studije bio da se ispita da li je gojaznost [merena indeksom telesne mase (ITM)] prediktor za nastanak hipertenzije, nezavisno od insulinske rezistencije [merene HOMA indeksom (HOMA-IR)] u kohorti žena u postmenopauzi. Metode: Ukupno 150 žena u postmenopauzi koje nisu na terapiji (među njima 44,7% sa hipertenzijom) su uključene u studiju preseka. Antropometrijski i biohemijski parametri, kao i krvni pritisak su mereni. HOMA-IR je računat. Rezultati: Multivarijantna logistička regresiona analiza je pokazala da su i ITM (OR=1,240; p=0,035) i HOMA-IR (OR=2,419; p=0,008)nezavisni prediktori krvnog pritiska kod žena u postmenopauzi. Povećanje ITMza1 kg/m2 povećava verovatnoću za pojavu hipertenzije za 24%. Takođe, porast HOMA-IR za 1 jedinicu povećava verovatnoću za pojavu hipertenzije za skoro 2,5 puta. Čak 47% varijacije u vrednosti krvnog pritiska može biti objašnjeno ovim modelom. Takođe, ovaj model je ispravno klasifikovao 76% žena u postmenopauzi koje imaju hipertenziju. Zaključak: I gojaznost, i insulinska rezistencija su nezavisni prediktori krvnog pritiska kod žena u postmenopauzi.",
publisher = "Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar",
journal = "Timočki medicinski glasnik",
title = "Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women, Indeks telesne mase i insulinska rezistencija kao nezavisni prediktori hipertenzije kod žena u postmenopauzi",
volume = "42",
number = "3",
pages = "165-172",
doi = "10.5937/tmg1703165K"
}

Klisić, A., Stanišić, V., Jovanović, M., Kavarić, N.,& Ninić, A.. (2017). Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women. in Timočki medicinski glasnik
Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar., 42(3), 165-172.
https://doi.org/10.5937/tmg1703165K

Klisić A, Stanišić V, Jovanović M, Kavarić N, Ninić A. Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women. in Timočki medicinski glasnik. 2017;42(3):165-172.
doi:10.5937/tmg1703165K .

Klisić, Aleksandra, Stanišić, Verica, Jovanović, Milovan, Kavarić, Nebojša, Ninić, Ana, "Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women" in Timočki medicinski glasnik, 42, no. 3 (2017):165-172,
https://doi.org/10.5937/tmg1703165K . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
AU  - Zvrko, Elvir
AU  - Skerović, Verica
AU  - Šćepanović, Anđelka
AU  - Medin, Darko
AU  - Ninić, Ana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2835
AB  - Background: Recent studies hypothesize that dyslipidemia can predict glycated hemoglobin (HbA1c) and could be important contributing factor to the pathogenesis of type 2 diabetes mellitus (DM2). Therefore, we aimed to evaluate the influence of lipid parameters on long-term glycemic control in DM2. Materials and Methods: A total of 275 sedentary DM2 (mean [+/- standard deviation] age 60.6 [+/- 10.0] years) who volunteered to participate in this cross-sectional study were enrolled. Anthropometric (body weight, body hight, and waist circumference), biochemical parameters (fasting glucose, HbA1c, lipid parameters, creatinine), as well as blood pressure were obtained. Results: Total cholesterol (odds ratio [OR] = 1.30, 95% confidence interval [CI] [1.02-1.66], P = 0.032), triglycerides (OR = 1.34, 95% CI (1.07-1.67), P = 0.010), and low density lipoprotein cholesterol (OR = 1.42, 95% CI [1.10-1.83], P = 0.006) were the independent predictors of higher HBA1c, and as they increased by 1 mmol/L each, probabilities of higher HBA1c increased by 30%, 34%, and 42%, respectively. Low level of high-density lipoprotein cholesterol (HDL-c) was found to be the independent predictor of higher HBA1c (OR = 0.44, 95% CI [0.20-0.67], P = 0.039), and increase in HDL-c by 1 mmol/L, reduced the probability of higher HBA1c by 56%. Conclusion: Unfavorable lipid profile can predict HbA1c level in DM2 patients. Early diagnosis of dyslipidemia, as well as its monitoring and maintaining good lipids control can be used as a preventive measure for optimal long-term glycemic control.
PB  - Wolters Kluwer Medknow Publications, Mumbai
T2  - Journal of Research in Medical Sciences
T1  - Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus
VL  - 22
DO  - 10.4103/jrms.JRMS_284_17
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Jovanović, Milovan and Zvrko, Elvir and Skerović, Verica and Šćepanović, Anđelka and Medin, Darko and Ninić, Ana",
year = "2017",
abstract = "Background: Recent studies hypothesize that dyslipidemia can predict glycated hemoglobin (HbA1c) and could be important contributing factor to the pathogenesis of type 2 diabetes mellitus (DM2). Therefore, we aimed to evaluate the influence of lipid parameters on long-term glycemic control in DM2. Materials and Methods: A total of 275 sedentary DM2 (mean [+/- standard deviation] age 60.6 [+/- 10.0] years) who volunteered to participate in this cross-sectional study were enrolled. Anthropometric (body weight, body hight, and waist circumference), biochemical parameters (fasting glucose, HbA1c, lipid parameters, creatinine), as well as blood pressure were obtained. Results: Total cholesterol (odds ratio [OR] = 1.30, 95% confidence interval [CI] [1.02-1.66], P = 0.032), triglycerides (OR = 1.34, 95% CI (1.07-1.67), P = 0.010), and low density lipoprotein cholesterol (OR = 1.42, 95% CI [1.10-1.83], P = 0.006) were the independent predictors of higher HBA1c, and as they increased by 1 mmol/L each, probabilities of higher HBA1c increased by 30%, 34%, and 42%, respectively. Low level of high-density lipoprotein cholesterol (HDL-c) was found to be the independent predictor of higher HBA1c (OR = 0.44, 95% CI [0.20-0.67], P = 0.039), and increase in HDL-c by 1 mmol/L, reduced the probability of higher HBA1c by 56%. Conclusion: Unfavorable lipid profile can predict HbA1c level in DM2 patients. Early diagnosis of dyslipidemia, as well as its monitoring and maintaining good lipids control can be used as a preventive measure for optimal long-term glycemic control.",
publisher = "Wolters Kluwer Medknow Publications, Mumbai",
journal = "Journal of Research in Medical Sciences",
title = "Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus",
volume = "22",
doi = "10.4103/jrms.JRMS_284_17"
}

Klisić, A., Kavarić, N., Jovanović, M., Zvrko, E., Skerović, V., Šćepanović, A., Medin, D.,& Ninić, A.. (2017). Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus. in Journal of Research in Medical Sciences
Wolters Kluwer Medknow Publications, Mumbai., 22.
https://doi.org/10.4103/jrms.JRMS_284_17

Klisić A, Kavarić N, Jovanović M, Zvrko E, Skerović V, Šćepanović A, Medin D, Ninić A. Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus. in Journal of Research in Medical Sciences. 2017;22.
doi:10.4103/jrms.JRMS_284_17 .

Klisić, Aleksandra, Kavarić, Nebojša, Jovanović, Milovan, Zvrko, Elvir, Skerović, Verica, Šćepanović, Anđelka, Medin, Darko, Ninić, Ana, "Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus" in Journal of Research in Medical Sciences, 22 (2017),
https://doi.org/10.4103/jrms.JRMS_284_17 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
AU  - Soldatović, Ivan
AU  - Gligorović-Barhanović, Najdana
AU  - Kotur-Stevuljević, Jelena
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2800
AB  - Introduction: Previous studies have examined the correlation between hyperandrogenemia and non-alcoholic fatty liver disease (NAFLD) in women and showed contradictory results. Therefore, we aimed to evaluate the relationship between testosterone level and Fatty Liver Index (FLI), as a surrogate marker for NAFLD, in a cohort of postmenopausal women. Material and methods: A total of 150 postmenopausal women were included in this cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure, were obtained. Non-alcoholic fatty liver disease is assessed by FLI, an algorithm based on body mass index, waist circumference, triglycerides and gamma-glutamyl transferase, as a simple and accurate predictor of hepatic steatosis. Women were divided into three groups (FLI  lt  30, n = 80; 30 = FLI  lt  60, n = 44; FLI = 60, n = 26). Homeostasis model assessment of insulin resistance (HOMA-IR) as a surrogate marker of insulin resistance was calculated. Results: Multiple linear regression analysis revealed that the best model consisted of 4 parameters (e.g., bioavailable testosterone (beta = 0.288, p = 0.001), log HOMA-IR (beta = 0.227, p = 0.005), log high-sensitivity C-reactive protein (beta = 0.322, p  lt  0.001), and retinol-binding protein 4 (beta = 0.226, p  lt  0.001)). Adjusted R-2 for the best model was 0.550, which means that as much as 55.0% of variation in FLI could be explained with this model. Conclusions: Bioavailable testosterone is independently associated with FLI in postmenopausal women.
PB  - Termedia Publishing House Ltd, Poznan
T2  - Archives of Medical Science
T1  - Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women
VL  - 13
IS  - 5
SP  - 1188
EP  - 1196
DO  - 10.5114/aoms.2017.68972
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Jovanović, Milovan and Soldatović, Ivan and Gligorović-Barhanović, Najdana and Kotur-Stevuljević, Jelena",
year = "2017",
abstract = "Introduction: Previous studies have examined the correlation between hyperandrogenemia and non-alcoholic fatty liver disease (NAFLD) in women and showed contradictory results. Therefore, we aimed to evaluate the relationship between testosterone level and Fatty Liver Index (FLI), as a surrogate marker for NAFLD, in a cohort of postmenopausal women. Material and methods: A total of 150 postmenopausal women were included in this cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure, were obtained. Non-alcoholic fatty liver disease is assessed by FLI, an algorithm based on body mass index, waist circumference, triglycerides and gamma-glutamyl transferase, as a simple and accurate predictor of hepatic steatosis. Women were divided into three groups (FLI  lt  30, n = 80; 30 = FLI  lt  60, n = 44; FLI = 60, n = 26). Homeostasis model assessment of insulin resistance (HOMA-IR) as a surrogate marker of insulin resistance was calculated. Results: Multiple linear regression analysis revealed that the best model consisted of 4 parameters (e.g., bioavailable testosterone (beta = 0.288, p = 0.001), log HOMA-IR (beta = 0.227, p = 0.005), log high-sensitivity C-reactive protein (beta = 0.322, p  lt  0.001), and retinol-binding protein 4 (beta = 0.226, p  lt  0.001)). Adjusted R-2 for the best model was 0.550, which means that as much as 55.0% of variation in FLI could be explained with this model. Conclusions: Bioavailable testosterone is independently associated with FLI in postmenopausal women.",
publisher = "Termedia Publishing House Ltd, Poznan",
journal = "Archives of Medical Science",
title = "Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women",
volume = "13",
number = "5",
pages = "1188-1196",
doi = "10.5114/aoms.2017.68972"
}

Klisić, A., Kavarić, N., Jovanović, M., Soldatović, I., Gligorović-Barhanović, N.,& Kotur-Stevuljević, J.. (2017). Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women. in Archives of Medical Science
Termedia Publishing House Ltd, Poznan., 13(5), 1188-1196.
https://doi.org/10.5114/aoms.2017.68972

Klisić A, Kavarić N, Jovanović M, Soldatović I, Gligorović-Barhanović N, Kotur-Stevuljević J. Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women. in Archives of Medical Science. 2017;13(5):1188-1196.
doi:10.5114/aoms.2017.68972 .

Klisić, Aleksandra, Kavarić, Nebojša, Jovanović, Milovan, Soldatović, Ivan, Gligorović-Barhanović, Najdana, Kotur-Stevuljević, Jelena, "Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women" in Archives of Medical Science, 13, no. 5 (2017):1188-1196,
https://doi.org/10.5114/aoms.2017.68972 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2766
AB  - Introduction: At physiological concentrations uric acid (UA) is a powerful antioxidant. However, at higher concentrations UA acts as an oxidant leading to cell damage and consequent risk for many diseases. The underlying mechanism of the relationship between higher UA level and obesityrelated diseases is not well elucidated. Therefore, the aim of the study was to determine the influence of obesity on serum UA level in postmenopausal women. Methods: A total of 100 overweight/obese postmenopausal women were included in this study. Anthropometric parameters: height, weight and waist circumference (WC) were measured, and body mass index was calculated in all participants. Biochemical parameters: uric acid, fasting glycemia, insulin resistance ((HOMA-IR) was calculated), lipid profile, cystatin C, retinol-binding protein 4 (RBP4), high sensitivity C-reactive protein were determined. Results: After dividing patients according to tertile values of UA concentration, significant increase in anthropometric measurements, HOMA-IR, cystatin C, RBP4, and blood pressure were found in the highest UA tertile. In multiple linear regression analysis, WC (Beta=0.414, p lt 0.001), and cystatin C (Beta=0.300, p lt 0.001), (R2=0.467; p lt 0.001) were the best predictors of higher UA level. Conclusion: Abdominal obesity is the imoprtant determinant of higher UA level in postmenopausal women. A better understanding of underlying mechanisms of hyperuricaemia and adipose tissue disfunction in obesity, such as dysregulation of adipokines and chronic inflammation, together with discovering new target therapy may be of paramount importantance for treating obestity complications.
AB  - Cilj: U fiziološkim koncentracijama mokraćna kiselina (MK) je moćan neenzimski antioksidans. Ipak, u povišenoj koncentraciji, MK ispoljava oksidativno dejstvo, dovodeći do oštećenja ćelije sa posledičnim rizikom za nastanak brojnih oboljenja. Mehanizam putem kojeg povećana koncentracija MK dovodi do oboljenja uzrokovanih gojaznošću nije u potpunosti razjašnjen. Zato je cilj naše studije da se ispita uticaj gojaznosti na serumski nivo MK kod žena u postmenopauzi. Metode: U ovom istraživanju je bilo uključeno 100 predgojaznih/gojaznih žena u postmenopauzi. Svim ispitanicama su izvršena antropometrijska merenja, koja su obuhvatila merenje telesne visine, telesne mase i obima struka. Indeks telesne mase je izračunat. Određivani su sledeći biohemijski parametri: MK, glikemija, (insulinska rezistencija [HOMA-IR]), lipidni status, cistatin C, retinol - vezujući protein (RBP4) i visokosenzitivni C-reaktivni protein. Rezultati: Podelom MK na tercilne vrednosti, uočene su najveće vrednosti antropometrijskih parametara, HOMA-IR, RBP4, cistatina C i krvnog pritiska u grupi sa najvišim vrednostima MK. Primenom višestruke linearne regresije, najveći uticaj na varijabilitet MK pokazao je obim struka (Beta=0,414; p lt 0,001), zatim cistatin C (Beta=0,300; p lt 0,001), (R2=0,467; p lt 0,001). Zaključak: Abdominalna gojaznost je važna determinanta povišenih vrednosti MK kod žena u postmenopauzi. Bolje razumevanje mehanizama koji dovode do hiperurikemije i disfunkcije masnog tkiva u gojaznosti, kao što su poremećena regulacija adipocitokina i hronična inflamacija, te otkrivanje dodatnih terapijskih ciljeva, može biti od velikog značaja u lečenju komplikacija gojaznosti.
PB  - Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar
T2  - Timočki medicinski glasnik
T1  - Influence of obesity on serum uric acid level in postmenopausal women
T1  - Uticaj gojaznosti na serumski nivo mokraćne kiseline kod žena u postmenopauzi
VL  - 41
IS  - 1
SP  - 20
EP  - 26
DO  - 10.5937/tmg1601020K
ER  - 

@article{
author = "Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Kavarić, Nebojša and Jovanović, Milovan",
year = "2016",
abstract = "Introduction: At physiological concentrations uric acid (UA) is a powerful antioxidant. However, at higher concentrations UA acts as an oxidant leading to cell damage and consequent risk for many diseases. The underlying mechanism of the relationship between higher UA level and obesityrelated diseases is not well elucidated. Therefore, the aim of the study was to determine the influence of obesity on serum UA level in postmenopausal women. Methods: A total of 100 overweight/obese postmenopausal women were included in this study. Anthropometric parameters: height, weight and waist circumference (WC) were measured, and body mass index was calculated in all participants. Biochemical parameters: uric acid, fasting glycemia, insulin resistance ((HOMA-IR) was calculated), lipid profile, cystatin C, retinol-binding protein 4 (RBP4), high sensitivity C-reactive protein were determined. Results: After dividing patients according to tertile values of UA concentration, significant increase in anthropometric measurements, HOMA-IR, cystatin C, RBP4, and blood pressure were found in the highest UA tertile. In multiple linear regression analysis, WC (Beta=0.414, p lt 0.001), and cystatin C (Beta=0.300, p lt 0.001), (R2=0.467; p lt 0.001) were the best predictors of higher UA level. Conclusion: Abdominal obesity is the imoprtant determinant of higher UA level in postmenopausal women. A better understanding of underlying mechanisms of hyperuricaemia and adipose tissue disfunction in obesity, such as dysregulation of adipokines and chronic inflammation, together with discovering new target therapy may be of paramount importantance for treating obestity complications., Cilj: U fiziološkim koncentracijama mokraćna kiselina (MK) je moćan neenzimski antioksidans. Ipak, u povišenoj koncentraciji, MK ispoljava oksidativno dejstvo, dovodeći do oštećenja ćelije sa posledičnim rizikom za nastanak brojnih oboljenja. Mehanizam putem kojeg povećana koncentracija MK dovodi do oboljenja uzrokovanih gojaznošću nije u potpunosti razjašnjen. Zato je cilj naše studije da se ispita uticaj gojaznosti na serumski nivo MK kod žena u postmenopauzi. Metode: U ovom istraživanju je bilo uključeno 100 predgojaznih/gojaznih žena u postmenopauzi. Svim ispitanicama su izvršena antropometrijska merenja, koja su obuhvatila merenje telesne visine, telesne mase i obima struka. Indeks telesne mase je izračunat. Određivani su sledeći biohemijski parametri: MK, glikemija, (insulinska rezistencija [HOMA-IR]), lipidni status, cistatin C, retinol - vezujući protein (RBP4) i visokosenzitivni C-reaktivni protein. Rezultati: Podelom MK na tercilne vrednosti, uočene su najveće vrednosti antropometrijskih parametara, HOMA-IR, RBP4, cistatina C i krvnog pritiska u grupi sa najvišim vrednostima MK. Primenom višestruke linearne regresije, najveći uticaj na varijabilitet MK pokazao je obim struka (Beta=0,414; p lt 0,001), zatim cistatin C (Beta=0,300; p lt 0,001), (R2=0,467; p lt 0,001). Zaključak: Abdominalna gojaznost je važna determinanta povišenih vrednosti MK kod žena u postmenopauzi. Bolje razumevanje mehanizama koji dovode do hiperurikemije i disfunkcije masnog tkiva u gojaznosti, kao što su poremećena regulacija adipocitokina i hronična inflamacija, te otkrivanje dodatnih terapijskih ciljeva, može biti od velikog značaja u lečenju komplikacija gojaznosti.",
publisher = "Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar",
journal = "Timočki medicinski glasnik",
title = "Influence of obesity on serum uric acid level in postmenopausal women, Uticaj gojaznosti na serumski nivo mokraćne kiseline kod žena u postmenopauzi",
volume = "41",
number = "1",
pages = "20-26",
doi = "10.5937/tmg1601020K"
}

Klisić, A., Kotur-Stevuljević, J., Kavarić, N.,& Jovanović, M.. (2016). Influence of obesity on serum uric acid level in postmenopausal women. in Timočki medicinski glasnik
Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar., 41(1), 20-26.
https://doi.org/10.5937/tmg1601020K

Klisić A, Kotur-Stevuljević J, Kavarić N, Jovanović M. Influence of obesity on serum uric acid level in postmenopausal women. in Timočki medicinski glasnik. 2016;41(1):20-26.
doi:10.5937/tmg1601020K .

Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Kavarić, Nebojša, Jovanović, Milovan, "Influence of obesity on serum uric acid level in postmenopausal women" in Timočki medicinski glasnik, 41, no. 1 (2016):20-26,
https://doi.org/10.5937/tmg1601020K . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
AU  - Škerović, Verica
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2709
AB  - Higher fibrinogen levels may play an important role in cardiovascular diseases in postmenopausal women. Previous studies have reported its higher levels in obese individuals, as compared with normal weight counterparts. However, the mechanism of the relationship between fibrinogen and cardiometabolic risk factors is not well elucidated. Therefore, we aimed to examine this relationship in overweight/obese postmenopausal women. Methods: A total of 100 overweight/obese postmenopausal women were included in this study. Blood pressure and anthropometric parameters: height, weight and waist circumference were measured, and body mass index (BMI) was calculated in all participants. Biochemical parameters: fibrinogen, glycemia, (insulin resistance (HOMA-IR) was calculated) and lipid profile (total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, triglycerides/HDLcholesterol ratio, non-HDL-cholesterol) were determined. Results: After dividing patients according to tertile values of fibrinogen concentration, significant increase in BMI (P=0.039), waist circumference (P=0.002), insulin (P=0.005), HOMA-IR (P=0.006), triglycerides (P=0.001), triglycerides/HDL-c ratio (P=0.002) and non-HDL-c (P=0.014) were found in the second and the third fibrinogen tertile, as compared with the first, the lowest level fibrinogen tertile. In multiple linear regression analysis, HOMAIR (Beta=0.225; p=0.007) and triglycerides (Beta=0.188; p=0.023), (R2=0.213; p lt 0.001) were the best predictors of higher fibrinogen level. Conclusion: Fibrinogen may be a useful marker in determining cardiovascular risk in obese postmenopausal women.
AB  - Visoke vrednosti fibrinogena mogu imati važnu ulogu u nastanku kardiovaskularnih bolesti, koje su vodeći uzrok smrtnosti kod žena u postmenopauzi. Ranije studije su pokazale više vrednosti fibrinogena kod gojaznih, u poređenju sa normalno uhranjenim osobama. Ipak, nedovoljno je rasvetljen mehanizam povezanosti fibrinogena sa kardiometaboličkim faktorima rizika koji prate gojaznost. Zato je cilj ove studije bio da se ispita ova povezanost u populaciji predgojaznih/gojaznih žena u postmenopauzi. Metode: U ovom istraživanju je bilo uključeno 100 predgojaznih/gojaznih žena u postmenopauzi. Svim ispitanicama meren je krvni pritisak i izvršena su antropometrijska merenja koja su obuhvatila merenje telesne visine, telesne mase i obima struka; izračunat je i indeks telesne mase (ITM). Određivani su sledeći biohemijski parametri: fibrinogen, glikemija, (insulinska rezistencija (HOMA-IR) je izračunata), lipidni status (ukupni holesterol, trigliceridi, LDL-holesterol, HDL-holesterol, odnos trigliceridi/HDL-holesterol, non-HDL-holesterol). Rezultati: Podelom fibrinogena na tercilne vrednosti, u drugoj i trećoj tercilnoj grupi uočene su više vrednosti ITM (P=0,039), obima struka (P=0,002), insulina (P=0,005), HOMA-IR (P=0,006), trigliceridi (P=0,001), odnos trigliceridi/HDL-holesterol (P=0,002) i non- HDL-holesterol (P=0,014) u poređenju sa prvom tercilnom grupom, tj. grupom sa najnižim vrednostima fibrinogena. Primenom višestruke linearne regresije, najveći uticaj na varijabilitet fibrinogena pokazali su HOMA-IR (beta=0,225; p=0,007) i nivo triglicerida (beta=0,188; p=0,023), (R2=0,213; p lt 0,001). Zaključak: Fibrinogen može biti koristan marker za procenu kardiometaboličkog rizika kod gojaznih žena u postmenopauzi.
PB  - Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar
T2  - Timočki medicinski glasnik
T1  - Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women
T1  - Korelacija fibrinogena sa kardiometaboličkim faktorima rizika kod predgojaznih/gojaznih žena u postmenopauzi
VL  - 41
IS  - 2
SP  - 83
EP  - 90
DO  - 10.5937/tmg1602083K
ER  - 

@article{
author = "Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Kavarić, Nebojša and Jovanović, Milovan and Škerović, Verica",
year = "2016",
abstract = "Higher fibrinogen levels may play an important role in cardiovascular diseases in postmenopausal women. Previous studies have reported its higher levels in obese individuals, as compared with normal weight counterparts. However, the mechanism of the relationship between fibrinogen and cardiometabolic risk factors is not well elucidated. Therefore, we aimed to examine this relationship in overweight/obese postmenopausal women. Methods: A total of 100 overweight/obese postmenopausal women were included in this study. Blood pressure and anthropometric parameters: height, weight and waist circumference were measured, and body mass index (BMI) was calculated in all participants. Biochemical parameters: fibrinogen, glycemia, (insulin resistance (HOMA-IR) was calculated) and lipid profile (total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, triglycerides/HDLcholesterol ratio, non-HDL-cholesterol) were determined. Results: After dividing patients according to tertile values of fibrinogen concentration, significant increase in BMI (P=0.039), waist circumference (P=0.002), insulin (P=0.005), HOMA-IR (P=0.006), triglycerides (P=0.001), triglycerides/HDL-c ratio (P=0.002) and non-HDL-c (P=0.014) were found in the second and the third fibrinogen tertile, as compared with the first, the lowest level fibrinogen tertile. In multiple linear regression analysis, HOMAIR (Beta=0.225; p=0.007) and triglycerides (Beta=0.188; p=0.023), (R2=0.213; p lt 0.001) were the best predictors of higher fibrinogen level. Conclusion: Fibrinogen may be a useful marker in determining cardiovascular risk in obese postmenopausal women., Visoke vrednosti fibrinogena mogu imati važnu ulogu u nastanku kardiovaskularnih bolesti, koje su vodeći uzrok smrtnosti kod žena u postmenopauzi. Ranije studije su pokazale više vrednosti fibrinogena kod gojaznih, u poređenju sa normalno uhranjenim osobama. Ipak, nedovoljno je rasvetljen mehanizam povezanosti fibrinogena sa kardiometaboličkim faktorima rizika koji prate gojaznost. Zato je cilj ove studije bio da se ispita ova povezanost u populaciji predgojaznih/gojaznih žena u postmenopauzi. Metode: U ovom istraživanju je bilo uključeno 100 predgojaznih/gojaznih žena u postmenopauzi. Svim ispitanicama meren je krvni pritisak i izvršena su antropometrijska merenja koja su obuhvatila merenje telesne visine, telesne mase i obima struka; izračunat je i indeks telesne mase (ITM). Određivani su sledeći biohemijski parametri: fibrinogen, glikemija, (insulinska rezistencija (HOMA-IR) je izračunata), lipidni status (ukupni holesterol, trigliceridi, LDL-holesterol, HDL-holesterol, odnos trigliceridi/HDL-holesterol, non-HDL-holesterol). Rezultati: Podelom fibrinogena na tercilne vrednosti, u drugoj i trećoj tercilnoj grupi uočene su više vrednosti ITM (P=0,039), obima struka (P=0,002), insulina (P=0,005), HOMA-IR (P=0,006), trigliceridi (P=0,001), odnos trigliceridi/HDL-holesterol (P=0,002) i non- HDL-holesterol (P=0,014) u poređenju sa prvom tercilnom grupom, tj. grupom sa najnižim vrednostima fibrinogena. Primenom višestruke linearne regresije, najveći uticaj na varijabilitet fibrinogena pokazali su HOMA-IR (beta=0,225; p=0,007) i nivo triglicerida (beta=0,188; p=0,023), (R2=0,213; p lt 0,001). Zaključak: Fibrinogen može biti koristan marker za procenu kardiometaboličkog rizika kod gojaznih žena u postmenopauzi.",
publisher = "Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar",
journal = "Timočki medicinski glasnik",
title = "Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women, Korelacija fibrinogena sa kardiometaboličkim faktorima rizika kod predgojaznih/gojaznih žena u postmenopauzi",
volume = "41",
number = "2",
pages = "83-90",
doi = "10.5937/tmg1602083K"
}

Klisić, A., Kotur-Stevuljević, J., Kavarić, N., Jovanović, M.,& Škerović, V.. (2016). Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women. in Timočki medicinski glasnik
Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar., 41(2), 83-90.
https://doi.org/10.5937/tmg1602083K

Klisić A, Kotur-Stevuljević J, Kavarić N, Jovanović M, Škerović V. Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women. in Timočki medicinski glasnik. 2016;41(2):83-90.
doi:10.5937/tmg1602083K .

Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Kavarić, Nebojša, Jovanović, Milovan, Škerović, Verica, "Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women" in Timočki medicinski glasnik, 41, no. 2 (2016):83-90,
https://doi.org/10.5937/tmg1602083K . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Soldatović, Ivan
AU  - Bjelaković, Bojko
AU  - Kotur-Stevuljević, Jelena
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2661
AB  - Background: Since the cardiovascular (CV) risk score in the young population, children and adolescents, is underestimated, especially in developing countries such as Montenegro, where a strong interaction exists between the genetically conditioned CV risk and environmental factors, the purpose of this study was to estimate CV risk in apparently healthy adolescent girls. Moreover, we aimed to test some new, emerging CV risk factors and their interaction with the traditional ones, such as obesity. Precisely, we aimed to assess the impact of low bilirubin levels, as a routine biochemical parameter, as an additional risk factor for atherosclerotic disease in the adult phase. Methods: Forty-five obese adolescent girls (mean age 17.8 +/- 1.22 years) and forty-five age-and sex-matched normal weight controls, all nonsmokers, were included. Anthropometric and biochemical parameters were measured. Cardiovascular Risk Score (CVRS) was calculated by adding the points for each risk factor (e.g. sex, HDL-c, non-HDLc, blood pressure and fasting glycemia). Results: A significant positive relationship between CVRS and ALT, hsCRP and TG/HDL-c, but an opposite relationship between CVRS and total bilirubin were found (P lt 0.001). Multiple linear regression analysis showed that higher waist circumference (WC) and LDL-c, but lower HDL-c were independent predictors of lower bilirubin values (adjusted R-2=0.603, P lt 0.001). Conclusions: Obese adolescent girls are at an increased risk of cardiovascular disease late in life. In addition to the traditional risk factors, total bilirubin may have the potential to discriminate between low and higher risk for cardiovascular disturbances in healthy adolescent girls.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls
VL  - 35
IS  - 3
SP  - 282
EP  - 292
DO  - 10.1515/jomb-2016-0005
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Soldatović, Ivan and Bjelaković, Bojko and Kotur-Stevuljević, Jelena",
year = "2016",
abstract = "Background: Since the cardiovascular (CV) risk score in the young population, children and adolescents, is underestimated, especially in developing countries such as Montenegro, where a strong interaction exists between the genetically conditioned CV risk and environmental factors, the purpose of this study was to estimate CV risk in apparently healthy adolescent girls. Moreover, we aimed to test some new, emerging CV risk factors and their interaction with the traditional ones, such as obesity. Precisely, we aimed to assess the impact of low bilirubin levels, as a routine biochemical parameter, as an additional risk factor for atherosclerotic disease in the adult phase. Methods: Forty-five obese adolescent girls (mean age 17.8 +/- 1.22 years) and forty-five age-and sex-matched normal weight controls, all nonsmokers, were included. Anthropometric and biochemical parameters were measured. Cardiovascular Risk Score (CVRS) was calculated by adding the points for each risk factor (e.g. sex, HDL-c, non-HDLc, blood pressure and fasting glycemia). Results: A significant positive relationship between CVRS and ALT, hsCRP and TG/HDL-c, but an opposite relationship between CVRS and total bilirubin were found (P lt 0.001). Multiple linear regression analysis showed that higher waist circumference (WC) and LDL-c, but lower HDL-c were independent predictors of lower bilirubin values (adjusted R-2=0.603, P lt 0.001). Conclusions: Obese adolescent girls are at an increased risk of cardiovascular disease late in life. In addition to the traditional risk factors, total bilirubin may have the potential to discriminate between low and higher risk for cardiovascular disturbances in healthy adolescent girls.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls",
volume = "35",
number = "3",
pages = "282-292",
doi = "10.1515/jomb-2016-0005"
}

Klisić, A., Kavarić, N., Soldatović, I., Bjelaković, B.,& Kotur-Stevuljević, J.. (2016). Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 35(3), 282-292.
https://doi.org/10.1515/jomb-2016-0005

Klisić A, Kavarić N, Soldatović I, Bjelaković B, Kotur-Stevuljević J. Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls. in Journal of Medical Biochemistry. 2016;35(3):282-292.
doi:10.1515/jomb-2016-0005 .

Klisić, Aleksandra, Kavarić, Nebojša, Soldatović, Ivan, Bjelaković, Bojko, Kotur-Stevuljević, Jelena, "Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls" in Journal of Medical Biochemistry, 35, no. 3 (2016):282-292,
https://doi.org/10.1515/jomb-2016-0005 . .