TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Radoman Vujačić, Irena
AU  - Kostadinović, Jelena
AU  - Patoulias, Dimitrios
AU  - Ninić, Ana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5576
AB  - OBJECTIVE: Although it is assumed that novel-derived anthropometric indices can better reflect cardiometabolic risk than traditional ones, the results are conflicting. Previous studies have mainly focused on patients with type 2 diabetes mellitus. However, studies conducted on populations with prediabetes are scarce. The present study aimed to examine the potential relationship between prediabetes and novel anthropometric parameters [that is, cardiometabolic index (CMI), visceral adiposity index (VAI), lipid accumulation product index (LAP), body roundness index (BRI), and body adiposity index (BAI)] and traditional parameters [that is, waist circumference (WC), hip circumference (HC), body mass index (BMI), waist-to-height ratio (WHtR), and waist-to-hip ratio (WHR)] in adults with prediabetes. PATIENTS AND METHODS: This case-control cross-sectional study included 177 patients with prediabetes and 609 control subjects. Biochemical and simple anthropometric parameters were measured (WC, HC, body weight, and height), whereas the other parameters were calculated. RESULTS: WC, CMI, VAI, and LAP independently correlated with prediabetes. Principal component analysis (PCA) was used to extract several factors that correlated with prediabetes. Significant predictive capability was demonstrated for non-traditional anthropometric/lipid-related factors and WHipR-related factors for prediabetes (OR=1.334 and OR=1.202, respectively). However, only non-traditional anthropometric/lipid-related factors (i.e., VAI, CMI, and LAP) demonstrated an independent significant positive relationship with prediabetes in multivariate binary regression analysis. CONCLUSIONS: CMI, VAI, and LAP could be superior to BAI, BRI, and conventional anthropometric parameters for discriminating patients with prediabetes in the adult population. Prospective trials are needed to confirm our results.
PB  - TREND MD
T2  - European review for medical and pharmacological sciences
T1  - Novel anthropometric parameters in the adult population with prediabetes
VL  - 27
IS  - 22
SP  - 11063
EP  - 11072
DO  - 10.26355/eurrev_202311_34475
ER  - 

@article{
author = "Klisić, Aleksandra and Radoman Vujačić, Irena and Kostadinović, Jelena and Patoulias, Dimitrios and Ninić, Ana",
year = "2023",
abstract = "OBJECTIVE: Although it is assumed that novel-derived anthropometric indices can better reflect cardiometabolic risk than traditional ones, the results are conflicting. Previous studies have mainly focused on patients with type 2 diabetes mellitus. However, studies conducted on populations with prediabetes are scarce. The present study aimed to examine the potential relationship between prediabetes and novel anthropometric parameters [that is, cardiometabolic index (CMI), visceral adiposity index (VAI), lipid accumulation product index (LAP), body roundness index (BRI), and body adiposity index (BAI)] and traditional parameters [that is, waist circumference (WC), hip circumference (HC), body mass index (BMI), waist-to-height ratio (WHtR), and waist-to-hip ratio (WHR)] in adults with prediabetes. PATIENTS AND METHODS: This case-control cross-sectional study included 177 patients with prediabetes and 609 control subjects. Biochemical and simple anthropometric parameters were measured (WC, HC, body weight, and height), whereas the other parameters were calculated. RESULTS: WC, CMI, VAI, and LAP independently correlated with prediabetes. Principal component analysis (PCA) was used to extract several factors that correlated with prediabetes. Significant predictive capability was demonstrated for non-traditional anthropometric/lipid-related factors and WHipR-related factors for prediabetes (OR=1.334 and OR=1.202, respectively). However, only non-traditional anthropometric/lipid-related factors (i.e., VAI, CMI, and LAP) demonstrated an independent significant positive relationship with prediabetes in multivariate binary regression analysis. CONCLUSIONS: CMI, VAI, and LAP could be superior to BAI, BRI, and conventional anthropometric parameters for discriminating patients with prediabetes in the adult population. Prospective trials are needed to confirm our results.",
publisher = "TREND MD",
journal = "European review for medical and pharmacological sciences",
title = "Novel anthropometric parameters in the adult population with prediabetes",
volume = "27",
number = "22",
pages = "11063-11072",
doi = "10.26355/eurrev_202311_34475"
}

Klisić, A., Radoman Vujačić, I., Kostadinović, J., Patoulias, D.,& Ninić, A.. (2023). Novel anthropometric parameters in the adult population with prediabetes. in European review for medical and pharmacological sciences
TREND MD., 27(22), 11063-11072.
https://doi.org/10.26355/eurrev_202311_34475

Klisić A, Radoman Vujačić I, Kostadinović J, Patoulias D, Ninić A. Novel anthropometric parameters in the adult population with prediabetes. in European review for medical and pharmacological sciences. 2023;27(22):11063-11072.
doi:10.26355/eurrev_202311_34475 .

Klisić, Aleksandra, Radoman Vujačić, Irena, Kostadinović, Jelena, Patoulias, Dimitrios, Ninić, Ana, "Novel anthropometric parameters in the adult population with prediabetes" in European review for medical and pharmacological sciences, 27, no. 22 (2023):11063-11072,
https://doi.org/10.26355/eurrev_202311_34475 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Vujačić, Radoman I.
AU  - Kostadinović, Jelena
AU  - Ninić, Ana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5569
AB  - OBJECTIVE: There are no studies that investigated the association between red blood cell (RBC) and platelet (PLT) indices in relation to obesity in a cohort of exclusively late adolescents. Hence, we aimed to explore this potential relationship. PATIENTS AND METHODS: A cohort of adolescents (n=156) aged between 16-19 years was included. Iron homeostasis parameters [i.e. RBC, hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) and red cell distribution width (RDW)] and platelet indices [i.e., PLT, mean platelet volume (MPV), plateletcrit (PCT) and platelet distribution width (PDW)] were determined on the automatic hematology analyzer. Their indexes (i.e., MCV/RBC, MCH/RBC, RDW/MCV, MPV/ PLT and PDW/PCT) were calculated. RESULTS: Univariate binary regression analysis showed negative associations between body mass index (BMI) and RDW, PDW, and PDW/PCT, respectively, and positive associations between BMI and MPV and PCT, respectively. However, only RDW kept the independent negative association with BMI in multivariate binary regression analysis [Odds Ratio (95% Confidence Interval)=0.734 (0.548-0.983); p=0.038]. CONCLUSIONS: Lower RDW values are the independent predictor of higher BMI in the adolescent population. As a low-cost and simply measured parameter, RDW could be a useful diagnostic biomarker in young populations with overweight/obesity.
PB  - Verduci Editore s.r.l
T2  - European Review for Medical and Pharmacological Sciences
T1  - Red cell distribution width is inversely associated with body mass index in late adolescents
VL  - 27
IS  - 15
SP  - 7148
EP  - 7154
DO  - 10.26355/eurrev_202308_33288
ER  - 

@article{
author = "Klisić, Aleksandra and Vujačić, Radoman I. and Kostadinović, Jelena and Ninić, Ana",
year = "2023",
abstract = "OBJECTIVE: There are no studies that investigated the association between red blood cell (RBC) and platelet (PLT) indices in relation to obesity in a cohort of exclusively late adolescents. Hence, we aimed to explore this potential relationship. PATIENTS AND METHODS: A cohort of adolescents (n=156) aged between 16-19 years was included. Iron homeostasis parameters [i.e. RBC, hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) and red cell distribution width (RDW)] and platelet indices [i.e., PLT, mean platelet volume (MPV), plateletcrit (PCT) and platelet distribution width (PDW)] were determined on the automatic hematology analyzer. Their indexes (i.e., MCV/RBC, MCH/RBC, RDW/MCV, MPV/ PLT and PDW/PCT) were calculated. RESULTS: Univariate binary regression analysis showed negative associations between body mass index (BMI) and RDW, PDW, and PDW/PCT, respectively, and positive associations between BMI and MPV and PCT, respectively. However, only RDW kept the independent negative association with BMI in multivariate binary regression analysis [Odds Ratio (95% Confidence Interval)=0.734 (0.548-0.983); p=0.038]. CONCLUSIONS: Lower RDW values are the independent predictor of higher BMI in the adolescent population. As a low-cost and simply measured parameter, RDW could be a useful diagnostic biomarker in young populations with overweight/obesity.",
publisher = "Verduci Editore s.r.l",
journal = "European Review for Medical and Pharmacological Sciences",
title = "Red cell distribution width is inversely associated with body mass index in late adolescents",
volume = "27",
number = "15",
pages = "7148-7154",
doi = "10.26355/eurrev_202308_33288"
}

Klisić, A., Vujačić, R. I., Kostadinović, J.,& Ninić, A.. (2023). Red cell distribution width is inversely associated with body mass index in late adolescents. in European Review for Medical and Pharmacological Sciences
Verduci Editore s.r.l., 27(15), 7148-7154.
https://doi.org/10.26355/eurrev_202308_33288

Klisić A, Vujačić RI, Kostadinović J, Ninić A. Red cell distribution width is inversely associated with body mass index in late adolescents. in European Review for Medical and Pharmacological Sciences. 2023;27(15):7148-7154.
doi:10.26355/eurrev_202308_33288 .

Klisić, Aleksandra, Vujačić, Radoman I., Kostadinović, Jelena, Ninić, Ana, "Red cell distribution width is inversely associated with body mass index in late adolescents" in European Review for Medical and Pharmacological Sciences, 27, no. 15 (2023):7148-7154,
https://doi.org/10.26355/eurrev_202308_33288 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Radoman-Vujačić, Irena
AU  - Kostadinović, Jelena
AU  - Ninić, Ana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5360
AB  - Background: To our knowledge, the mutual involvement of a variety of metabolic and renal biomarkers and vitamin D (determined as 25-hydroxyvitamin D [25(OH)D]) in postmenopausal women has not been examined yet. Therefore, we aimed to explore such a relationship by a thorough statistical multimarker approach. Methods: A total of 150 (diabetes and cardiovascular disease-free) postmenopausal women were included. Anthropometric and biochemical parameters were measured. The fatty liver index (FLI) and Homeostasis model assessment of insulin resistance (HOMA-IR) were calculated. Univariate and multivariate binary logistic regression analyses were used to test the predictions of cardiometabolic markers for [25(OH)D] status. Principal component analysis (PCA) was applied to explore the effect of examined biomarkers on [25(OH)D] status. Results: Univariate binary regression analysis revealed positive associations between FLI and [25(OH)D] [OR=1.036 (1.020–1.052), P<0.001] and HOMA-IR with [25(OH)D] [OR=2.385 (1.601–3.551), P<0.001]. Multivariate logistic regression analysis with backward selection enabled us to find the best model consisted of two markers, i.e. FLI [OR=1.032 (1.016–1.048), P<0.001] and glucose [OR=2.167 (1.001–4.693), P=0.050] associated with the first tertile of [25(OH)D]. PCA extracted 2 significant factors: Renal function-related factor and Metabolic syndrome-related factor. Renal function-related factor [i.e. creatinine, uric acid, retinol-binding protein 4 (RBP4) and cystatin C] explained 29% of the variance. Also, Metabolic syndrome-related factor (i.e. HOMA-IR, FLI, hsCRP and fibrinogen) explained 29% of the variance of the tested parameters. Moreover, binary logistic regression analysis revealed significant positive predictive ability of both factors, i.e. Renal function-related factor and Metabolic syndrome-related factor (P=0.044 and P<0.001, respectively) towards [25(OH)D] status.
Conclusion: The joint involvement of renal function
biomarkers and metabolic syndrome-related features (i.e.
insulin resistance, inflammation and non-alcoholic fatty
liver disease) can differentiate postmenopausal women
with lower [25(OH)D] levels from other women.
AB  - Uvod: Prema našem saznanju zajednički uticaj različitih
metaboličkih i renalnih biomarkera na nivo vitamin D
(odre|enog kao 25-hidroksivitamin D [25(OH)D]) kod
žena u postmenopauzi još uvijek nije ispitivan. Stoga je cilj
istraživanja bio da se ispita povezanost ovih biomarkera
primenom temeljne statističke analize koja uključuje više
navedenih biomarkera.
Metode: Ukupno 150 žena u postmenopauzi (koje nemaju
dijabetes, ni kardiovaskularna oboljenja) je uključeno u
istraživanje. Mereni su antropometrijski i biohemijski parametri. Indeks masne jetre (FLI) i indeks insulinske rezistencije (HOMA-IR) su izračunati. Univarijantna i multivarijantna
binarna logistička regresija su primenjene da bi se odredili
kardiometabolički prediktori nivoa [25(OH)D].
Rezultati: Univarijantna binarna regresiona analiza je
pokazala pozitivnu korelaciju izme|u FLI i [25(OH)D]
[OR=1.036 (1.020–1.052), P<0,001] i HOMA-IR sa
[25(OH)D] [OR=2.385 (1.601–3.551), P<0,001].
Multivarijantna logistička regresiona analiza je pokazala
najbolji model sa 2 markera, tj. FLI [OR=1.032 (1.016–
1.048), P<0,001] i glukoza [OR=2.167 (1.001–4.693),
P=0,050] koji su korelirali sa prvom tercilom vrednosti
[25(OH)D]. PCA je izdvojila 2 značajna faktora: Renal
function-related faktor i Metabolic syndrome-related faktor.
Renal function-related faktor [tj. kreatinin, mokraćna kiselina, retinolvezujui protein 4 (RBP4) i cistatin C] su
objasnili 29% varijanse. Takođe, Metabolic syndrome-
related faktor (tj. HOMA-IR, FLI, hsCRP i fibrinogen) su
objasnili 29% varijanse ispitivanih parametara. štaviše,
binarna logistička regresiona analiza je pokazala pozitivnu
prediktivnu sposobnost oba faktora, tj. Renal function-
related faktora i Metabolic syndrome-related faktora
(P=0,044 i P<0,001) za nivo [25(OH)D].
Zaključak: Zajedničko dejstvo renalnih biomarkera i
markera metaboličkog sindroma (tj. insulinska rezistencija,
inflamacija i nealkoholna steatoza jetre) mogu diferencirati
žene u postmenopauzi sa nižim nivoom [25(OH)D] u
odnosu na ostale žene.
PB  - Society of Medical Biochemists of Serbia
T2  - Journal of Medical Biochemistry
T1  - The correlation of metabolic and renal biomarkers with vitamin D status in postmenopausal women
T1  - Korelacija renalnih i metaboličkih biomarkera sa nivoom vitamina D kod žena u postmenopauzi
VL  - 42
IS  - 4
SP  - 565
EP  - 573
DO  - 10.5937/jomb0-41044
ER  - 

@article{
author = "Klisić, Aleksandra and Radoman-Vujačić, Irena and Kostadinović, Jelena and Ninić, Ana",
year = "2023",
abstract = "Background: To our knowledge, the mutual involvement of a variety of metabolic and renal biomarkers and vitamin D (determined as 25-hydroxyvitamin D [25(OH)D]) in postmenopausal women has not been examined yet. Therefore, we aimed to explore such a relationship by a thorough statistical multimarker approach. Methods: A total of 150 (diabetes and cardiovascular disease-free) postmenopausal women were included. Anthropometric and biochemical parameters were measured. The fatty liver index (FLI) and Homeostasis model assessment of insulin resistance (HOMA-IR) were calculated. Univariate and multivariate binary logistic regression analyses were used to test the predictions of cardiometabolic markers for [25(OH)D] status. Principal component analysis (PCA) was applied to explore the effect of examined biomarkers on [25(OH)D] status. Results: Univariate binary regression analysis revealed positive associations between FLI and [25(OH)D] [OR=1.036 (1.020–1.052), P<0.001] and HOMA-IR with [25(OH)D] [OR=2.385 (1.601–3.551), P<0.001]. Multivariate logistic regression analysis with backward selection enabled us to find the best model consisted of two markers, i.e. FLI [OR=1.032 (1.016–1.048), P<0.001] and glucose [OR=2.167 (1.001–4.693), P=0.050] associated with the first tertile of [25(OH)D]. PCA extracted 2 significant factors: Renal function-related factor and Metabolic syndrome-related factor. Renal function-related factor [i.e. creatinine, uric acid, retinol-binding protein 4 (RBP4) and cystatin C] explained 29% of the variance. Also, Metabolic syndrome-related factor (i.e. HOMA-IR, FLI, hsCRP and fibrinogen) explained 29% of the variance of the tested parameters. Moreover, binary logistic regression analysis revealed significant positive predictive ability of both factors, i.e. Renal function-related factor and Metabolic syndrome-related factor (P=0.044 and P<0.001, respectively) towards [25(OH)D] status.
Conclusion: The joint involvement of renal function
biomarkers and metabolic syndrome-related features (i.e.
insulin resistance, inflammation and non-alcoholic fatty
liver disease) can differentiate postmenopausal women
with lower [25(OH)D] levels from other women., Uvod: Prema našem saznanju zajednički uticaj različitih
metaboličkih i renalnih biomarkera na nivo vitamin D
(odre|enog kao 25-hidroksivitamin D [25(OH)D]) kod
žena u postmenopauzi još uvijek nije ispitivan. Stoga je cilj
istraživanja bio da se ispita povezanost ovih biomarkera
primenom temeljne statističke analize koja uključuje više
navedenih biomarkera.
Metode: Ukupno 150 žena u postmenopauzi (koje nemaju
dijabetes, ni kardiovaskularna oboljenja) je uključeno u
istraživanje. Mereni su antropometrijski i biohemijski parametri. Indeks masne jetre (FLI) i indeks insulinske rezistencije (HOMA-IR) su izračunati. Univarijantna i multivarijantna
binarna logistička regresija su primenjene da bi se odredili
kardiometabolički prediktori nivoa [25(OH)D].
Rezultati: Univarijantna binarna regresiona analiza je
pokazala pozitivnu korelaciju izme|u FLI i [25(OH)D]
[OR=1.036 (1.020–1.052), P<0,001] i HOMA-IR sa
[25(OH)D] [OR=2.385 (1.601–3.551), P<0,001].
Multivarijantna logistička regresiona analiza je pokazala
najbolji model sa 2 markera, tj. FLI [OR=1.032 (1.016–
1.048), P<0,001] i glukoza [OR=2.167 (1.001–4.693),
P=0,050] koji su korelirali sa prvom tercilom vrednosti
[25(OH)D]. PCA je izdvojila 2 značajna faktora: Renal
function-related faktor i Metabolic syndrome-related faktor.
Renal function-related faktor [tj. kreatinin, mokraćna kiselina, retinolvezujui protein 4 (RBP4) i cistatin C] su
objasnili 29% varijanse. Takođe, Metabolic syndrome-
related faktor (tj. HOMA-IR, FLI, hsCRP i fibrinogen) su
objasnili 29% varijanse ispitivanih parametara. štaviše,
binarna logistička regresiona analiza je pokazala pozitivnu
prediktivnu sposobnost oba faktora, tj. Renal function-
related faktora i Metabolic syndrome-related faktora
(P=0,044 i P<0,001) za nivo [25(OH)D].
Zaključak: Zajedničko dejstvo renalnih biomarkera i
markera metaboličkog sindroma (tj. insulinska rezistencija,
inflamacija i nealkoholna steatoza jetre) mogu diferencirati
žene u postmenopauzi sa nižim nivoom [25(OH)D] u
odnosu na ostale žene.",
publisher = "Society of Medical Biochemists of Serbia",
journal = "Journal of Medical Biochemistry",
title = "The correlation of metabolic and renal biomarkers with vitamin D status in postmenopausal women, Korelacija renalnih i metaboličkih biomarkera sa nivoom vitamina D kod žena u postmenopauzi",
volume = "42",
number = "4",
pages = "565-573",
doi = "10.5937/jomb0-41044"
}

Klisić, A., Radoman-Vujačić, I., Kostadinović, J.,& Ninić, A.. (2023). The correlation of metabolic and renal biomarkers with vitamin D status in postmenopausal women. in Journal of Medical Biochemistry
Society of Medical Biochemists of Serbia., 42(4), 565-573.
https://doi.org/10.5937/jomb0-41044

Klisić A, Radoman-Vujačić I, Kostadinović J, Ninić A. The correlation of metabolic and renal biomarkers with vitamin D status in postmenopausal women. in Journal of Medical Biochemistry. 2023;42(4):565-573.
doi:10.5937/jomb0-41044 .

Klisić, Aleksandra, Radoman-Vujačić, Irena, Kostadinović, Jelena, Ninić, Ana, "The correlation of metabolic and renal biomarkers with vitamin D status in postmenopausal women" in Journal of Medical Biochemistry, 42, no. 4 (2023):565-573,
https://doi.org/10.5937/jomb0-41044 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Cojić, Milena
AU  - Patoulias, Dimitrios
AU  - Ninić, Ana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5228
AB  - Objective: Previous studies suggested that ethnic differences, sex and obesity could modify the relationship between 25-hydroxyvitamin D [25(OH)D], glycometabolic markers and/or type 2 di- abetes mellitus (T2D). We aimed to examine the potential relationship between [25(OH)D] and T2D in postmenopausal women in Montenegro. In addition, we aimed to explore if a set of biomarkers, rather than [25(OH)D] as a single biomarker, could better explain its potential association with T2D. Patients and Methods: A total of 116 postmenopausal, otherwise healthy women and 48 postmenopausal women with T2D were included. Univariable and multivariable binary logistic regression analy- sis, along with principal component analysis (PCA), were applied to test the associations between examined biomarkers/set of biomarkers with T2D. Results: Women with T2D had lower serum [25(OH)D] levels than healthy controls (p = 0.024). No independent relationship between [25(OH)D] and T2D was found. PCA extracted three significant factors that were associated with T2D, i.e., age-glycometabolic-related factor (i.e., with positive loadings of age, glucose and insulin; OR = 11.321, p < 0.001), obesity-inflammation- related factor (i.e., with positive loadings of hsCRP and WC, and negative loading of [25(OH)D]; (OR = 2.079, p < 0.001)) and lipid-related factor (i.e., with positive loadings of TG and LDL-c, and negative loading of HDL-c; OR = 1.423, p = 0.044). Conclusions: The relationship between [25(OH)D] and T2D is modulated by central obesity (as measured by WC) and inflammation (as measured with hsCRP) in postmenopausal women. Their joint measurement, rather than [25(OH)D] itself, could provide better information for the risk assessment for T2D in postmenopausal women.
PB  - MDPI
T2  - Biomedicines
T1  - Multimarker Approach as More Reliable Method Than Single Vitamin D in Relationship with Type 2 Diabetes Mellitus in Montenegrin Postmenopausal Women
VL  - 11
IS  - 10
DO  - 10.3390/biomedicines11102610
ER  - 

@article{
author = "Klisić, Aleksandra and Cojić, Milena and Patoulias, Dimitrios and Ninić, Ana",
year = "2023",
abstract = "Objective: Previous studies suggested that ethnic differences, sex and obesity could modify the relationship between 25-hydroxyvitamin D [25(OH)D], glycometabolic markers and/or type 2 di- abetes mellitus (T2D). We aimed to examine the potential relationship between [25(OH)D] and T2D in postmenopausal women in Montenegro. In addition, we aimed to explore if a set of biomarkers, rather than [25(OH)D] as a single biomarker, could better explain its potential association with T2D. Patients and Methods: A total of 116 postmenopausal, otherwise healthy women and 48 postmenopausal women with T2D were included. Univariable and multivariable binary logistic regression analy- sis, along with principal component analysis (PCA), were applied to test the associations between examined biomarkers/set of biomarkers with T2D. Results: Women with T2D had lower serum [25(OH)D] levels than healthy controls (p = 0.024). No independent relationship between [25(OH)D] and T2D was found. PCA extracted three significant factors that were associated with T2D, i.e., age-glycometabolic-related factor (i.e., with positive loadings of age, glucose and insulin; OR = 11.321, p < 0.001), obesity-inflammation- related factor (i.e., with positive loadings of hsCRP and WC, and negative loading of [25(OH)D]; (OR = 2.079, p < 0.001)) and lipid-related factor (i.e., with positive loadings of TG and LDL-c, and negative loading of HDL-c; OR = 1.423, p = 0.044). Conclusions: The relationship between [25(OH)D] and T2D is modulated by central obesity (as measured by WC) and inflammation (as measured with hsCRP) in postmenopausal women. Their joint measurement, rather than [25(OH)D] itself, could provide better information for the risk assessment for T2D in postmenopausal women.",
publisher = "MDPI",
journal = "Biomedicines",
title = "Multimarker Approach as More Reliable Method Than Single Vitamin D in Relationship with Type 2 Diabetes Mellitus in Montenegrin Postmenopausal Women",
volume = "11",
number = "10",
doi = "10.3390/biomedicines11102610"
}

Klisić, A., Cojić, M., Patoulias, D.,& Ninić, A.. (2023). Multimarker Approach as More Reliable Method Than Single Vitamin D in Relationship with Type 2 Diabetes Mellitus in Montenegrin Postmenopausal Women. in Biomedicines
MDPI., 11(10).
https://doi.org/10.3390/biomedicines11102610

Klisić A, Cojić M, Patoulias D, Ninić A. Multimarker Approach as More Reliable Method Than Single Vitamin D in Relationship with Type 2 Diabetes Mellitus in Montenegrin Postmenopausal Women. in Biomedicines. 2023;11(10).
doi:10.3390/biomedicines11102610 .

Klisić, Aleksandra, Cojić, Milena, Patoulias, Dimitrios, Ninić, Ana, "Multimarker Approach as More Reliable Method Than Single Vitamin D in Relationship with Type 2 Diabetes Mellitus in Montenegrin Postmenopausal Women" in Biomedicines, 11, no. 10 (2023),
https://doi.org/10.3390/biomedicines11102610 . .

TY  - JOUR
AU  - Malenica, Maja
AU  - Klisić, Aleksandra
AU  - Meseldžić, Neven
AU  - Dujić, Tanja
AU  - Bego, Tamer
AU  - Kotur-Stevuljević, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4992
AB  - Background: The aim of the study was to explore the mutual relationship between oxidative stress, inflammation and
metabolic biomarkers in subjects with prediabetes (PRE),
newly diagnosed type 2 diabetes patients (NT2D) and overt
type 2 diabetes (T2D) using principal component analysis
(PCA) as a thorough statistical approach.
Methods: Glycated hemoglobin, lipid parameters, inflammation (IL-6, CRP and fibrinogen) and oxidative stress
markers  pro-oxidants (AOPP, PAB, TOS) and antioxidants
(PON1, tSHG, TAS)  were measured. PCA was applied to
explore the factors that the most strongly influenced glucoregulation.
Results: A total of 278 subjects were (i.e., 37 PRE, 42
NT2D and 99 T2D) were compared with 100 healthy subjects as a control group (CG). PCA emphasized 4 different
factors explaining 49% of the variance of the tested parameters: oxidative stress-dyslipidemia related factor (with positive loading of TG and tSHG, and with negative loading of
HDL-c and TAS), dyslipidaemia related factor (i.e., total
cholesterol and LDL-c, both with positive loading),
Anthropometric related factor (i.e., waist and hip circumference, both with positive loading) and oxidative stress-
Inflammation related factor (i.e., PAB, fibrinogen, and CRP, all with positive loading). Out of these 4 factors, only oxidative stress – dyslipidaemia related factor showed a significant predictive capability towards poor glucoregulation. An
increase in this factor by one unit showed a 1.6 times higher probability for poor glucoregulation.
Conclusions: Redox imbalance (determined with lower TAS
and higher tSHG), in addition to higher TG and lower HDL-
c was associated with poor glucoregulation.
AB  - Uvod: Cilj istraživanja je bio da se ispita povezanost oksidativnog stresa, inflamacije i metaboličkih biomarkera kod pacijenata sa predijabetesom (PRE), de novo dijabetesom (NT2D) i ranije dijagnostikovanim dijabetesom (T2D) pomoću glavne komponentne analize (PCA). Metode: Glikozilirani hemoglobin, lipidni status, markeri inflamacije (IL-6, CRP i fibrinogen), parametri oksidativnog stresa pro-oksidanti (AOPP, PAB, TOS) i antioksidansi (PON1, tSHG, TAS) su mereni. PCA je primenjena da bi se ispitali faktori koji najviše utiču na glikoregulaciju. Rezultati: U istraživanje je uključeno 278 ispitanika: 37 PRE, 42 NT2D i 99 T2D, kao i 100 zdravih osoba koji su činili kontrolnu grupu (CG). PCA je izdvojila 4 različita faktora objašnjavajući 49% varijanse ispitivanih parametara: oksidativni stres-dislipidemija faktor (sa pozitivnim uticajem TG i tSHG, i negativnim uticajem HDL-c i TAS), dislipidemija faktor (tj, ukupni holesterol i LDL-c, oba sa pozitivnim uticajem), antropometrijski faktor (tj, obim struka i kukova, oba sa pozitivnim uticajem) i oksidativni stres-inflamacija faktor (tj, PAB, fibrinogen i CRP, svi sa pozitivnim uticajem). Od ova 4 faktora, jedino je oksidativni stres - dislipidemija faktor pokazao značajnu prediktivnu sposobnost za lošu glikoregulaciju. Porast ovog faktora za jednu jedinicu je pokazao 1,6 puta veću verovatnoću za lošu glikoregulaciju. Zaključak: Redoks disbalans (određen nižim vrednostima TAS i višim vrednostima tSHG), kao dodatak većim vrednostima TG i nižim vrednostima HDL-c su povezane sa lošijom glikoregulacijom.
PB  - Society of Medical Biochemists of Serbia
T2  - Journal of Medical Biochemistry
T1  - Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation
T1  - Glavna komponentna analiza uticaja oksidativnog stresa, inflamacije i dislipidemije kod pacijenata sa različitim nivoom glikoregulacije
VL  - 42
IS  - 3
SP  - 427
EP  - 436
DO  - 10.5937/jomb0-39636
ER  - 

@article{
author = "Malenica, Maja and Klisić, Aleksandra and Meseldžić, Neven and Dujić, Tanja and Bego, Tamer and Kotur-Stevuljević, Jelena",
year = "2023",
abstract = "Background: The aim of the study was to explore the mutual relationship between oxidative stress, inflammation and
metabolic biomarkers in subjects with prediabetes (PRE),
newly diagnosed type 2 diabetes patients (NT2D) and overt
type 2 diabetes (T2D) using principal component analysis
(PCA) as a thorough statistical approach.
Methods: Glycated hemoglobin, lipid parameters, inflammation (IL-6, CRP and fibrinogen) and oxidative stress
markers  pro-oxidants (AOPP, PAB, TOS) and antioxidants
(PON1, tSHG, TAS)  were measured. PCA was applied to
explore the factors that the most strongly influenced glucoregulation.
Results: A total of 278 subjects were (i.e., 37 PRE, 42
NT2D and 99 T2D) were compared with 100 healthy subjects as a control group (CG). PCA emphasized 4 different
factors explaining 49% of the variance of the tested parameters: oxidative stress-dyslipidemia related factor (with positive loading of TG and tSHG, and with negative loading of
HDL-c and TAS), dyslipidaemia related factor (i.e., total
cholesterol and LDL-c, both with positive loading),
Anthropometric related factor (i.e., waist and hip circumference, both with positive loading) and oxidative stress-
Inflammation related factor (i.e., PAB, fibrinogen, and CRP, all with positive loading). Out of these 4 factors, only oxidative stress – dyslipidaemia related factor showed a significant predictive capability towards poor glucoregulation. An
increase in this factor by one unit showed a 1.6 times higher probability for poor glucoregulation.
Conclusions: Redox imbalance (determined with lower TAS
and higher tSHG), in addition to higher TG and lower HDL-
c was associated with poor glucoregulation., Uvod: Cilj istraživanja je bio da se ispita povezanost oksidativnog stresa, inflamacije i metaboličkih biomarkera kod pacijenata sa predijabetesom (PRE), de novo dijabetesom (NT2D) i ranije dijagnostikovanim dijabetesom (T2D) pomoću glavne komponentne analize (PCA). Metode: Glikozilirani hemoglobin, lipidni status, markeri inflamacije (IL-6, CRP i fibrinogen), parametri oksidativnog stresa pro-oksidanti (AOPP, PAB, TOS) i antioksidansi (PON1, tSHG, TAS) su mereni. PCA je primenjena da bi se ispitali faktori koji najviše utiču na glikoregulaciju. Rezultati: U istraživanje je uključeno 278 ispitanika: 37 PRE, 42 NT2D i 99 T2D, kao i 100 zdravih osoba koji su činili kontrolnu grupu (CG). PCA je izdvojila 4 različita faktora objašnjavajući 49% varijanse ispitivanih parametara: oksidativni stres-dislipidemija faktor (sa pozitivnim uticajem TG i tSHG, i negativnim uticajem HDL-c i TAS), dislipidemija faktor (tj, ukupni holesterol i LDL-c, oba sa pozitivnim uticajem), antropometrijski faktor (tj, obim struka i kukova, oba sa pozitivnim uticajem) i oksidativni stres-inflamacija faktor (tj, PAB, fibrinogen i CRP, svi sa pozitivnim uticajem). Od ova 4 faktora, jedino je oksidativni stres - dislipidemija faktor pokazao značajnu prediktivnu sposobnost za lošu glikoregulaciju. Porast ovog faktora za jednu jedinicu je pokazao 1,6 puta veću verovatnoću za lošu glikoregulaciju. Zaključak: Redoks disbalans (određen nižim vrednostima TAS i višim vrednostima tSHG), kao dodatak većim vrednostima TG i nižim vrednostima HDL-c su povezane sa lošijom glikoregulacijom.",
publisher = "Society of Medical Biochemists of Serbia",
journal = "Journal of Medical Biochemistry",
title = "Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation, Glavna komponentna analiza uticaja oksidativnog stresa, inflamacije i dislipidemije kod pacijenata sa različitim nivoom glikoregulacije",
volume = "42",
number = "3",
pages = "427-436",
doi = "10.5937/jomb0-39636"
}

Malenica, M., Klisić, A., Meseldžić, N., Dujić, T., Bego, T.,& Kotur-Stevuljević, J.. (2023). Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation. in Journal of Medical Biochemistry
Society of Medical Biochemists of Serbia., 42(3), 427-436.
https://doi.org/10.5937/jomb0-39636

Malenica M, Klisić A, Meseldžić N, Dujić T, Bego T, Kotur-Stevuljević J. Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation. in Journal of Medical Biochemistry. 2023;42(3):427-436.
doi:10.5937/jomb0-39636 .

Malenica, Maja, Klisić, Aleksandra, Meseldžić, Neven, Dujić, Tanja, Bego, Tamer, Kotur-Stevuljević, Jelena, "Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation" in Journal of Medical Biochemistry, 42, no. 3 (2023):427-436,
https://doi.org/10.5937/jomb0-39636 . .

TY  - JOUR
AU  - Brborić, Jasmina
AU  - Klisić, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Delogu, Giovanna
AU  - Gjorgieva Ackova, Darinka
AU  - Kostić, Kristina
AU  - Dettori, Maria Antonietta
AU  - Fabbri, Davide
AU  - Carta, Paola
AU  - Saso, Luciano
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4964
AB  - Introduction: Phenols are a large family of natural and synthetic compounds with known antioxidant activity. The aim of this study was to perform in vitro screening of natural and natural-like phenol monomers and their C2-symmetric dimers (hydroxylated biphenyls) in order to identify those representatives whose pharmacophores have the strongest antioxidant and the lowest prooxidant activity. Material and methods: Antioxidative properties of 36 compounds (monomers and their C2-symmetric dimers) were evaluated in vitro. Different (red/ ox) assays were used to measure their total oxidative potential (TOP), their total antioxidative capacity (TAC), the pro-oxidative-antioxidant balance (PAB) and total SH-group content (SHG) in a biologically relevant environment. The Pro-oxidative Score, Antioxidative Score and the Oxy Score were also calculated. Trolox, a water soluble analogue of α-tocopherol, was used as a positive control. Results: In an assay consisting of pooled human serum, 6 of the 36 compounds showed significant antioxidant activity (compounds 6, 7, 12, 13, 26, and 27), whereas 4 showed extremely weak antioxidant activity (compounds 2, 29, 30, and 31). Within the 36 compounds comprising zingerone, dehydrozingerone, aurone, chalcone, and magnolol derivatives, in both monomeric and dimeric forms, the 2 compounds that indicated the highest antioxidant activity were dehydrozingerone derivatives (compounds 6 and 12). Trolox’s activity was found between the strong and weak antioxidant compounds analysed in our study. Conclusions: In this study selected dehydrozingerones were identified as good candidates for in-depth testing of their biological behaviour and for possible precursors for synthesis of novel polyphenolic molecules with potential therapeutic applications.
PB  - Termedia Publishing House
T2  - Archives of Medical Science
T1  - Natural and natural-like polyphenol compounds: in vitro antioxidant activity and potential for therapeutic application
VL  - 19
IS  - 3
SP  - 651
EP  - 671
DO  - 10.5114/aoms/135379
ER  - 

@article{
author = "Brborić, Jasmina and Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Delogu, Giovanna and Gjorgieva Ackova, Darinka and Kostić, Kristina and Dettori, Maria Antonietta and Fabbri, Davide and Carta, Paola and Saso, Luciano",
year = "2023",
abstract = "Introduction: Phenols are a large family of natural and synthetic compounds with known antioxidant activity. The aim of this study was to perform in vitro screening of natural and natural-like phenol monomers and their C2-symmetric dimers (hydroxylated biphenyls) in order to identify those representatives whose pharmacophores have the strongest antioxidant and the lowest prooxidant activity. Material and methods: Antioxidative properties of 36 compounds (monomers and their C2-symmetric dimers) were evaluated in vitro. Different (red/ ox) assays were used to measure their total oxidative potential (TOP), their total antioxidative capacity (TAC), the pro-oxidative-antioxidant balance (PAB) and total SH-group content (SHG) in a biologically relevant environment. The Pro-oxidative Score, Antioxidative Score and the Oxy Score were also calculated. Trolox, a water soluble analogue of α-tocopherol, was used as a positive control. Results: In an assay consisting of pooled human serum, 6 of the 36 compounds showed significant antioxidant activity (compounds 6, 7, 12, 13, 26, and 27), whereas 4 showed extremely weak antioxidant activity (compounds 2, 29, 30, and 31). Within the 36 compounds comprising zingerone, dehydrozingerone, aurone, chalcone, and magnolol derivatives, in both monomeric and dimeric forms, the 2 compounds that indicated the highest antioxidant activity were dehydrozingerone derivatives (compounds 6 and 12). Trolox’s activity was found between the strong and weak antioxidant compounds analysed in our study. Conclusions: In this study selected dehydrozingerones were identified as good candidates for in-depth testing of their biological behaviour and for possible precursors for synthesis of novel polyphenolic molecules with potential therapeutic applications.",
publisher = "Termedia Publishing House",
journal = "Archives of Medical Science",
title = "Natural and natural-like polyphenol compounds: in vitro antioxidant activity and potential for therapeutic application",
volume = "19",
number = "3",
pages = "651-671",
doi = "10.5114/aoms/135379"
}

Brborić, J., Klisić, A., Kotur-Stevuljević, J., Delogu, G., Gjorgieva Ackova, D., Kostić, K., Dettori, M. A., Fabbri, D., Carta, P.,& Saso, L.. (2023). Natural and natural-like polyphenol compounds: in vitro antioxidant activity and potential for therapeutic application. in Archives of Medical Science
Termedia Publishing House., 19(3), 651-671.
https://doi.org/10.5114/aoms/135379

Brborić J, Klisić A, Kotur-Stevuljević J, Delogu G, Gjorgieva Ackova D, Kostić K, Dettori MA, Fabbri D, Carta P, Saso L. Natural and natural-like polyphenol compounds: in vitro antioxidant activity and potential for therapeutic application. in Archives of Medical Science. 2023;19(3):651-671.
doi:10.5114/aoms/135379 .

Brborić, Jasmina, Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Delogu, Giovanna, Gjorgieva Ackova, Darinka, Kostić, Kristina, Dettori, Maria Antonietta, Fabbri, Davide, Carta, Paola, Saso, Luciano, "Natural and natural-like polyphenol compounds: in vitro antioxidant activity and potential for therapeutic application" in Archives of Medical Science, 19, no. 3 (2023):651-671,
https://doi.org/10.5114/aoms/135379 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Kotur, Jelena
AU  - Ninić, Ana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4963
AB  - Introduction: Markers of iron homeostasis are related to insulin resistance (IR) in adults. However, studies in children and adolescents are scarce and show contradictory results. The aim was to evaluate the potential relationship between iron status markers and IR. Additionally, no previous study has explored the mutual effect of biomarkers of iron homeostasis and inflammation (i.e. high sensitivity C-reactive protein (hsCRP)), and adipokines (i.e. retinol-binding protein 4 (RBP4)) on IR in the cohort of adolescent girls. Material and methods: A total of 60 girls age between 16 and 19 years were included in the study. Serum levels of ferritin, transferrin, soluble transferrin receptor (sTfR), hsCRP, and RBP4 were measured by immunonephelometry. Homeostasis model assessment of insulin resistance (HOMA-IR) and iron homeostasis indexes were calculated. Univariate and multivariate binary logistic regression analysis were used to investigate the possible independent associations of the examined biomarkers. Principal component analysis was used to examine their mutual effect on HOMA-IR in the studied girls. Results: Ferritin, sTfR, hsCRP and RBP4 were significant predictors for higher HOMA-IR in univariate analysis (p = 0.020, p = 0.009, p = 0.007, p = 0.003, respectively). Multivariate regression analysis after adjustment for waist circumference (WC) showed that serum sTfR levels remained positively associated with higher HOMA-IR (p = 0.044). Factorial analysis revealed that the obesity-inflammation related factor (i.e., WC and hsCRP) and adipokine- acute phase protein related factor (i.e., RBP4 and ferritin) showed significant differences between HOMA-IR < 2.5 and HOMA-IR ≥ 2.5. Conclusions: Serum sTfR levels are independently associated with HOMA-IR, whereas higher serum ferritin levels together with higher RBP4 are related to higher HOMA-IR in adolescent girls.
PB  - Termedia Publishing House
T2  - Archives of Medical Science
T1  - Serum soluble transferrin receptor levels are independently associated with homeostasis model assessment of insulin resistance in adolescent girls
VL  - 19
IS  - 4
SP  - 987
EP  - 994
DO  - 10.5114/aoms/132757
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Kotur, Jelena and Ninić, Ana",
year = "2023",
abstract = "Introduction: Markers of iron homeostasis are related to insulin resistance (IR) in adults. However, studies in children and adolescents are scarce and show contradictory results. The aim was to evaluate the potential relationship between iron status markers and IR. Additionally, no previous study has explored the mutual effect of biomarkers of iron homeostasis and inflammation (i.e. high sensitivity C-reactive protein (hsCRP)), and adipokines (i.e. retinol-binding protein 4 (RBP4)) on IR in the cohort of adolescent girls. Material and methods: A total of 60 girls age between 16 and 19 years were included in the study. Serum levels of ferritin, transferrin, soluble transferrin receptor (sTfR), hsCRP, and RBP4 were measured by immunonephelometry. Homeostasis model assessment of insulin resistance (HOMA-IR) and iron homeostasis indexes were calculated. Univariate and multivariate binary logistic regression analysis were used to investigate the possible independent associations of the examined biomarkers. Principal component analysis was used to examine their mutual effect on HOMA-IR in the studied girls. Results: Ferritin, sTfR, hsCRP and RBP4 were significant predictors for higher HOMA-IR in univariate analysis (p = 0.020, p = 0.009, p = 0.007, p = 0.003, respectively). Multivariate regression analysis after adjustment for waist circumference (WC) showed that serum sTfR levels remained positively associated with higher HOMA-IR (p = 0.044). Factorial analysis revealed that the obesity-inflammation related factor (i.e., WC and hsCRP) and adipokine- acute phase protein related factor (i.e., RBP4 and ferritin) showed significant differences between HOMA-IR < 2.5 and HOMA-IR ≥ 2.5. Conclusions: Serum sTfR levels are independently associated with HOMA-IR, whereas higher serum ferritin levels together with higher RBP4 are related to higher HOMA-IR in adolescent girls.",
publisher = "Termedia Publishing House",
journal = "Archives of Medical Science",
title = "Serum soluble transferrin receptor levels are independently associated with homeostasis model assessment of insulin resistance in adolescent girls",
volume = "19",
number = "4",
pages = "987-994",
doi = "10.5114/aoms/132757"
}

Klisić, A., Kavarić, N., Kotur, J.,& Ninić, A.. (2023). Serum soluble transferrin receptor levels are independently associated with homeostasis model assessment of insulin resistance in adolescent girls. in Archives of Medical Science
Termedia Publishing House., 19(4), 987-994.
https://doi.org/10.5114/aoms/132757

Klisić A, Kavarić N, Kotur J, Ninić A. Serum soluble transferrin receptor levels are independently associated with homeostasis model assessment of insulin resistance in adolescent girls. in Archives of Medical Science. 2023;19(4):987-994.
doi:10.5114/aoms/132757 .

Klisić, Aleksandra, Kavarić, Nebojša, Kotur, Jelena, Ninić, Ana, "Serum soluble transferrin receptor levels are independently associated with homeostasis model assessment of insulin resistance in adolescent girls" in Archives of Medical Science, 19, no. 4 (2023):987-994,
https://doi.org/10.5114/aoms/132757 . .

TY  - JOUR
AU  - Vukašinović, Aleksandra
AU  - Ostanek, Barbara
AU  - Klisić, Aleksandra
AU  - Kafedžić, Srđan
AU  - Zdravković, Marija
AU  - Ilić, Ivan
AU  - Sopić, Miron
AU  - Hinić, Saša
AU  - Stefanović, Milica
AU  - Memon, Lidija
AU  - Gaković, Branka
AU  - Bogavac-Stanojević, Nataša
AU  - Spasojević-Kalimanovska, Vesna
AU  - Marc, Janja
AU  - Nešković, Aleksandar
AU  - Kotur-Stevuljević, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4677
AB  - Introduction: Telomeres are protective chromosomal ends. Short telomeres are a proven biomarker of biological aging. We aimed to find an association of telomere length and telomerase activity in circulating leukocytes and thromboaspirates of patients with acute myocardial infarction. Furthermore, association of the telomere-telomerase system with oxidative stress markers (as common risk factors for coronary artery disease (CAD)) was tested. Material and methods: Patients were selected from the patients admitted to the intensive care unit with acute myocardial infarction with ST-segment elevation (STEMI), with the following inclusion criteria – STEMI patients between 18 and 80 years old of both genders and candidates for primary percutaneous coronary intervention, with infarction pain present for a maximum of 12 h. In all the patients leukocyte telomere length, telomerase activity and scores related to oxidative-stress status (Protective, Damage and OXY) were evaluated. Results: Patients were divided into different groups: with stable angina pectoris (AP) (n = 22), acute myocardial infarction with: STEMI (n = 93), non-obstructive coronary arteries (MINOCA) (n = 7), blood vessel rupture (n = 6) at three time points, and compared to the group of 84 healthy subjects. Telomerase activity was significantly higher in all CAD sub-groups compared to the control group (AP = 0.373 (0.355–0.386), STEMI = 0.375 (0.349–0.395), MINOCA = 0.391 (0.366–0.401), blood vessel rupture = 0.360 (0.352–0.385) vs. CG = 0.069 (0.061–0.081), p < 0.001), while telomeres were significantly shorter in STEMI, MINOCA and blood vessel rupture groups compared to the control group (STEMI = 1.179 (0.931–1.376), MINOCA = 1.026 (0.951–1.070), blood vessel rupture = 1.089 (0.842–1.173) vs. CG = 1.329 (1.096–1.624), p = 0.030]. Values of OXY score were significantly higher in STEMI and MINOCA patients compared to the control group and AP patients (5.83 (4.55–7.54) and 10.28 (9.19–10.72) vs. 4.94 (3.29–6.18) and 4.18 (2.58–4.86), p < 0.001). Longer telomeres and higher telomerase activity were found in thromboaspirates, compared to the peripheral blood leukocytes in the same patients (1.25 (1.01–1.84) vs. 1.18 (0.909–1.516), p = 0.036; and 0.366 (0.367–0.379) vs. 0.366 (0.367–0.379), p < 0.001, respectively). In addition, telomere length and telomerase activity had good diagnostic ability to separate STEMI patients from healthy persons. Conclusions: Leukocyte telomere length and telomerase activity can differentiate CAD patients from healthy persons, and relate CAD to oxidative stress.
PB  - Termedia Publishing House Ltd.
T2  - Archives of Medical Science
T1  - Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress
VL  - 19
IS  - 2
SP  - 313
EP  - 323
DO  - 10.5114/aoms/136074
ER  - 

@article{
author = "Vukašinović, Aleksandra and Ostanek, Barbara and Klisić, Aleksandra and Kafedžić, Srđan and Zdravković, Marija and Ilić, Ivan and Sopić, Miron and Hinić, Saša and Stefanović, Milica and Memon, Lidija and Gaković, Branka and Bogavac-Stanojević, Nataša and Spasojević-Kalimanovska, Vesna and Marc, Janja and Nešković, Aleksandar and Kotur-Stevuljević, Jelena",
year = "2023",
abstract = "Introduction: Telomeres are protective chromosomal ends. Short telomeres are a proven biomarker of biological aging. We aimed to find an association of telomere length and telomerase activity in circulating leukocytes and thromboaspirates of patients with acute myocardial infarction. Furthermore, association of the telomere-telomerase system with oxidative stress markers (as common risk factors for coronary artery disease (CAD)) was tested. Material and methods: Patients were selected from the patients admitted to the intensive care unit with acute myocardial infarction with ST-segment elevation (STEMI), with the following inclusion criteria – STEMI patients between 18 and 80 years old of both genders and candidates for primary percutaneous coronary intervention, with infarction pain present for a maximum of 12 h. In all the patients leukocyte telomere length, telomerase activity and scores related to oxidative-stress status (Protective, Damage and OXY) were evaluated. Results: Patients were divided into different groups: with stable angina pectoris (AP) (n = 22), acute myocardial infarction with: STEMI (n = 93), non-obstructive coronary arteries (MINOCA) (n = 7), blood vessel rupture (n = 6) at three time points, and compared to the group of 84 healthy subjects. Telomerase activity was significantly higher in all CAD sub-groups compared to the control group (AP = 0.373 (0.355–0.386), STEMI = 0.375 (0.349–0.395), MINOCA = 0.391 (0.366–0.401), blood vessel rupture = 0.360 (0.352–0.385) vs. CG = 0.069 (0.061–0.081), p < 0.001), while telomeres were significantly shorter in STEMI, MINOCA and blood vessel rupture groups compared to the control group (STEMI = 1.179 (0.931–1.376), MINOCA = 1.026 (0.951–1.070), blood vessel rupture = 1.089 (0.842–1.173) vs. CG = 1.329 (1.096–1.624), p = 0.030]. Values of OXY score were significantly higher in STEMI and MINOCA patients compared to the control group and AP patients (5.83 (4.55–7.54) and 10.28 (9.19–10.72) vs. 4.94 (3.29–6.18) and 4.18 (2.58–4.86), p < 0.001). Longer telomeres and higher telomerase activity were found in thromboaspirates, compared to the peripheral blood leukocytes in the same patients (1.25 (1.01–1.84) vs. 1.18 (0.909–1.516), p = 0.036; and 0.366 (0.367–0.379) vs. 0.366 (0.367–0.379), p < 0.001, respectively). In addition, telomere length and telomerase activity had good diagnostic ability to separate STEMI patients from healthy persons. Conclusions: Leukocyte telomere length and telomerase activity can differentiate CAD patients from healthy persons, and relate CAD to oxidative stress.",
publisher = "Termedia Publishing House Ltd.",
journal = "Archives of Medical Science",
title = "Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress",
volume = "19",
number = "2",
pages = "313-323",
doi = "10.5114/aoms/136074"
}

Vukašinović, A., Ostanek, B., Klisić, A., Kafedžić, S., Zdravković, M., Ilić, I., Sopić, M., Hinić, S., Stefanović, M., Memon, L., Gaković, B., Bogavac-Stanojević, N., Spasojević-Kalimanovska, V., Marc, J., Nešković, A.,& Kotur-Stevuljević, J.. (2023). Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress. in Archives of Medical Science
Termedia Publishing House Ltd.., 19(2), 313-323.
https://doi.org/10.5114/aoms/136074

Vukašinović A, Ostanek B, Klisić A, Kafedžić S, Zdravković M, Ilić I, Sopić M, Hinić S, Stefanović M, Memon L, Gaković B, Bogavac-Stanojević N, Spasojević-Kalimanovska V, Marc J, Nešković A, Kotur-Stevuljević J. Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress. in Archives of Medical Science. 2023;19(2):313-323.
doi:10.5114/aoms/136074 .

Vukašinović, Aleksandra, Ostanek, Barbara, Klisić, Aleksandra, Kafedžić, Srđan, Zdravković, Marija, Ilić, Ivan, Sopić, Miron, Hinić, Saša, Stefanović, Milica, Memon, Lidija, Gaković, Branka, Bogavac-Stanojević, Nataša, Spasojević-Kalimanovska, Vesna, Marc, Janja, Nešković, Aleksandar, Kotur-Stevuljević, Jelena, "Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress" in Archives of Medical Science, 19, no. 2 (2023):313-323,
https://doi.org/10.5114/aoms/136074 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Malenica, Maja
AU  - Kostadinović, Jelena
AU  - Kocić, Gordana
AU  - Ninić, Ana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4646
AB  - Background: Given the fact that the studies that examined
oxidative stress in relation to obesity that included late
adolescents are scarce and show inconclusive results we
aimed to investigate a wide spectrum of nitro-oxidative
stress biomarkers  i.e., malondialdehyde (MDA), xanthine
oxidase (XO), xanthine oxidoreductase (XOD), xanthine
dehydrogenase (XDH), advanced oxidation protein
products (AOPP) and nitric oxide products (NOx), as well
as an antioxidative enzyme, i.e., catalase (CAT)  in relation
with obesity in the cohort of adolescent girls ages between
16 and 19 years old.
Methods: A total of 59 teenage girls were included in this
cross-sectional study. Binary logistic regression analysis was
performed to examine possible associations between bio-
chemical and nitro-oxidative stress markers and body mass
index (BMI).
Results: There were not significant differences between
oxidative stress markers between normal weight and
overweight/obese girls (i.e., AOPP, XOD, XO, XDH) and
CAT, except for MDA (p<0.001) and NOx (p=0.010)
concentrations which were significantly higher in overweight/obese adolescent girls. Positive associations
were evident between BMI and high sensitivity C-reactive
protein (hsCRP) (OR=2.495), BMI and uric acid
(OR=1.024) and BMI and MDA (OR=1.062).
Multivariable binary regression analysis demonstrated sig-
nificant independent associations of BMI and hsCRP
(OR=2.150) and BMI and MDA (OR=1.105). Even
76.3% of the variation in BMI could be explained with this
Model.
Conclusions: Inflammation (as measured with hsCRP) and
oxidative stress (as determined with MDA) independently
correlated with BMI in teenage girls.
AB  - Uvod: Imajući u vidu činjenicu da je malo studija koje su ispitivale povezanost oksidativnog stresa i gojaznosti kod adolescenata i da iste pokazuju oprečne rezultate, cilj istraživanja je bio da se ispita povezanost širokog spektra biomarkera nitro-oksidativnog stresa tj. malondialdehida (MDA), ksantin oksidaze (XO), ksantin oksidoreduktaze (XOD), ksantin dehidrogenaze (XDH), produkata uznapredovale oksidacije proteina (AOPP) i produkata azot-monoksida (NOx), kao i enzima antioksidativne zaštite, tj. katalaze (CAT) i gojaznosti u kohorti adolescentkinja starosne dobi izme|u 16 i 19 godina. Metode: Ukupno 59 tinejdžerki je uključeno u ovu studiju preseka. Binarna logistička regresija je primenjena u cilju ispitivanja potencijalne povezanosti između biohemijskih markera i markera nitro-oksidativnog stresa i indeksa telesne mase (ITM). Rezultati: Nije uočena razlika u biomarkerima oksidativnog stresa između normalno uhranjenih i predgojaznih/gojaznih adolescentkinja (odnosno AOPP, XOD, XO, XDH) i CAT, osim u vrednostima MDA (p<0,001) i NOx (p=0,010) koje su bile značajno veće kod predgojaznih/gojaznih adolescentkinja. Pozitivna korelacija je utvrđena izme|u ITM-a i visokosenzitivnog C-reaktivnog proteina (hsCRP) (OR=2,495), ITM-a i mokraćne kiseline (OR=1,024) i ITM-a i MDA (OR=1,062). Multivarijanta binarna regresija je pokazala nezavisnu povezanost ITM-a i hsCRP (OR=2,150), kao i ITM-a i MDA (OR=1,105). Čak 76,3% varijabiliteta ITM-a može biti objašnjeno ovim modelom. Zaključak: Inflamacija (merena hsCRP-om) i oksidativni stres (meren malondialdehidom) nezavisno koreliraju sa ITM kod adolescentkinja.
PB  - Društvo medicinskih biohemičara Srbije, Beograd
T2  - Journal of Medical Biochemistry
T1  - Malondialdehyde as an independent predictor of body mass index in adolescent girls
T1  - Malondialdehid kao nezavisan prediktor indeksa telesne mase kod adolescentkinja
VL  - 42
IS  - 2
SP  - 224
EP  - 231
DO  - 10.5937/jomb0-39044
ER  - 

@article{
author = "Klisić, Aleksandra and Malenica, Maja and Kostadinović, Jelena and Kocić, Gordana and Ninić, Ana",
year = "2023",
abstract = "Background: Given the fact that the studies that examined
oxidative stress in relation to obesity that included late
adolescents are scarce and show inconclusive results we
aimed to investigate a wide spectrum of nitro-oxidative
stress biomarkers  i.e., malondialdehyde (MDA), xanthine
oxidase (XO), xanthine oxidoreductase (XOD), xanthine
dehydrogenase (XDH), advanced oxidation protein
products (AOPP) and nitric oxide products (NOx), as well
as an antioxidative enzyme, i.e., catalase (CAT)  in relation
with obesity in the cohort of adolescent girls ages between
16 and 19 years old.
Methods: A total of 59 teenage girls were included in this
cross-sectional study. Binary logistic regression analysis was
performed to examine possible associations between bio-
chemical and nitro-oxidative stress markers and body mass
index (BMI).
Results: There were not significant differences between
oxidative stress markers between normal weight and
overweight/obese girls (i.e., AOPP, XOD, XO, XDH) and
CAT, except for MDA (p<0.001) and NOx (p=0.010)
concentrations which were significantly higher in overweight/obese adolescent girls. Positive associations
were evident between BMI and high sensitivity C-reactive
protein (hsCRP) (OR=2.495), BMI and uric acid
(OR=1.024) and BMI and MDA (OR=1.062).
Multivariable binary regression analysis demonstrated sig-
nificant independent associations of BMI and hsCRP
(OR=2.150) and BMI and MDA (OR=1.105). Even
76.3% of the variation in BMI could be explained with this
Model.
Conclusions: Inflammation (as measured with hsCRP) and
oxidative stress (as determined with MDA) independently
correlated with BMI in teenage girls., Uvod: Imajući u vidu činjenicu da je malo studija koje su ispitivale povezanost oksidativnog stresa i gojaznosti kod adolescenata i da iste pokazuju oprečne rezultate, cilj istraživanja je bio da se ispita povezanost širokog spektra biomarkera nitro-oksidativnog stresa tj. malondialdehida (MDA), ksantin oksidaze (XO), ksantin oksidoreduktaze (XOD), ksantin dehidrogenaze (XDH), produkata uznapredovale oksidacije proteina (AOPP) i produkata azot-monoksida (NOx), kao i enzima antioksidativne zaštite, tj. katalaze (CAT) i gojaznosti u kohorti adolescentkinja starosne dobi izme|u 16 i 19 godina. Metode: Ukupno 59 tinejdžerki je uključeno u ovu studiju preseka. Binarna logistička regresija je primenjena u cilju ispitivanja potencijalne povezanosti između biohemijskih markera i markera nitro-oksidativnog stresa i indeksa telesne mase (ITM). Rezultati: Nije uočena razlika u biomarkerima oksidativnog stresa između normalno uhranjenih i predgojaznih/gojaznih adolescentkinja (odnosno AOPP, XOD, XO, XDH) i CAT, osim u vrednostima MDA (p<0,001) i NOx (p=0,010) koje su bile značajno veće kod predgojaznih/gojaznih adolescentkinja. Pozitivna korelacija je utvrđena izme|u ITM-a i visokosenzitivnog C-reaktivnog proteina (hsCRP) (OR=2,495), ITM-a i mokraćne kiseline (OR=1,024) i ITM-a i MDA (OR=1,062). Multivarijanta binarna regresija je pokazala nezavisnu povezanost ITM-a i hsCRP (OR=2,150), kao i ITM-a i MDA (OR=1,105). Čak 76,3% varijabiliteta ITM-a može biti objašnjeno ovim modelom. Zaključak: Inflamacija (merena hsCRP-om) i oksidativni stres (meren malondialdehidom) nezavisno koreliraju sa ITM kod adolescentkinja.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd",
journal = "Journal of Medical Biochemistry",
title = "Malondialdehyde as an independent predictor of body mass index in adolescent girls, Malondialdehid kao nezavisan prediktor indeksa telesne mase kod adolescentkinja",
volume = "42",
number = "2",
pages = "224-231",
doi = "10.5937/jomb0-39044"
}

Klisić, A., Malenica, M., Kostadinović, J., Kocić, G.,& Ninić, A.. (2023). Malondialdehyde as an independent predictor of body mass index in adolescent girls. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd., 42(2), 224-231.
https://doi.org/10.5937/jomb0-39044

Klisić A, Malenica M, Kostadinović J, Kocić G, Ninić A. Malondialdehyde as an independent predictor of body mass index in adolescent girls. in Journal of Medical Biochemistry. 2023;42(2):224-231.
doi:10.5937/jomb0-39044 .

Klisić, Aleksandra, Malenica, Maja, Kostadinović, Jelena, Kocić, Gordana, Ninić, Ana, "Malondialdehyde as an independent predictor of body mass index in adolescent girls" in Journal of Medical Biochemistry, 42, no. 2 (2023):224-231,
https://doi.org/10.5937/jomb0-39044 . .

TY  - JOUR
AU  - Kostadinović, Jelena
AU  - Popadić, Višeslav
AU  - Klašnja, Slobodan
AU  - Klisić, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Andrić, Zoran
AU  - Zdravković, Marija
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4629
AB  - The clinical efficacy of chemotherapy, as a recognized therapeutic approach for malignant 
diseases,   usually   has   certain   limitations   due   to   its   cardiotoxicity   (CT)   and   consequent   
cardiomyopathy,  or  even  heart  failure.  CT
  is  defined  as  any  cardiac  injury  connected  with  
oncology treatment, whether it is chemo
-, radio
-, targeted or immunotherapy, or cancer by itself, 
and it represents a great challenge for clinicians in everyday practice. A wide spectrum of factors 
related t
o chemotherapy (type of drug, dose during each cycle, cumulative dose, schedule, method 
of  application,  combination  with  other  cardiotoxic  drugs  or  association  with  radiotherapy)  and  
patient  characteristics  (age,  presence  of  cardiovascular  risk  factors,  pr
evious  cardiovascular  
disease)  are  the  determining  factors  that  influence  the  frequency  of  CT.  Imaging  methods  for  
morphological  and  functional  monitoring  of  the  heart  muscle  are  used  for  monitoring  CT.  The  
quest  for  diagnostic  tools  for  early  CT  detection 
is  of  great  significance.  In  line  with  this,  the  
measurement  of  some  cardiac  biomarkers  has  found  its  place  in  clinical  settings  as  an  early  
determinant of myocardial injury. Therefore, in this review article, special attention will be paid 
to  certain  wel
l-established,  as  well  as  certain  novel  cardiac  biomarkers,  and  their  role  in  
recognizing asymptomatic CT, in order to gain deeper insight into their diagnostic utility.
AB  - Klinička  efikasnost  hemioterapije,  kao  priznatog  terapeutskog  pristupa  malignim 
bolestima, obično ima određena ograničenja zbog svoje kardiotoksičnosti (KT), te posledične 
kardiomiopatije, pa čak i srčane insuficijencije. KT se definiše kao svaka povreda miokarda 
povezana  s  lečenjem  raka,  uzimajući  u  obzir  hemioterapiju,  radioterapiju,  biološku  ili 
imunoterapiju,  kao  i  sam  karcinom,  te  predstavlja veliki  izazov  za  kliničare 
u  svakodnevnoj  
praksi. Širok spektar faktora povezanih s hemioterapijom (vrsta leka, doza tokom svakog ciklusa, 
kumulativna doza, raspored, način primene, kombinacija s drugim kardiotoksičnim lekovima ili 
povezanost s radioterapijom) i karakteristike bolesnika (dob, prisutnost faktora kardiovaskularnog 
rizika, prethodne kardiovaskularne bolesti), odlučujući su faktori koji utiču na učestalost KT. Za 
praćenje KT koriste se radiološke metode za morfološko i funkcionalno praćenje srčanog mišića. 
Potraga za dij
agnostičkim alatima za rano otkrivanje KT od velikog je značaja. U skladu s tim, 
merenje nekih srčanih biomarkera kao rane determinante povrede miokarda našlo je svoje mesto 
u kliničkim okruženjima. Stoga 
će u ovom preglednom članku posebna pažnja biti po
sve
ć
ena 
nekim  dobro  utvrđenim,  kao  i  nekim  novim  srčanim  biomarkerima,  i  njihovoj  ulozi  u 
prepoznavanju asimptomatske KT, kako bi se stekao dublji uvid u njihovu dijagnostičku korisnost 
i neželjene efekte lekova koji se primenjuju u terapiji karcinoma.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
T2  - Arhiv za farmaciju
T1  - Cardiotoxicity: Importance of biomarkers
T1  - Kardiotoksičnost: Važnost biomarkera
VL  - 73
IS  - 1
SP  - 1
EP  - 16
DO  - 10.5937/arhfarm73-40534
ER  - 

@article{
author = "Kostadinović, Jelena and Popadić, Višeslav and Klašnja, Slobodan and Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Andrić, Zoran and Zdravković, Marija",
year = "2023",
abstract = "The clinical efficacy of chemotherapy, as a recognized therapeutic approach for malignant 
diseases,   usually   has   certain   limitations   due   to   its   cardiotoxicity   (CT)   and   consequent   
cardiomyopathy,  or  even  heart  failure.  CT
  is  defined  as  any  cardiac  injury  connected  with  
oncology treatment, whether it is chemo
-, radio
-, targeted or immunotherapy, or cancer by itself, 
and it represents a great challenge for clinicians in everyday practice. A wide spectrum of factors 
related t
o chemotherapy (type of drug, dose during each cycle, cumulative dose, schedule, method 
of  application,  combination  with  other  cardiotoxic  drugs  or  association  with  radiotherapy)  and  
patient  characteristics  (age,  presence  of  cardiovascular  risk  factors,  pr
evious  cardiovascular  
disease)  are  the  determining  factors  that  influence  the  frequency  of  CT.  Imaging  methods  for  
morphological  and  functional  monitoring  of  the  heart  muscle  are  used  for  monitoring  CT.  The  
quest  for  diagnostic  tools  for  early  CT  detection 
is  of  great  significance.  In  line  with  this,  the  
measurement  of  some  cardiac  biomarkers  has  found  its  place  in  clinical  settings  as  an  early  
determinant of myocardial injury. Therefore, in this review article, special attention will be paid 
to  certain  wel
l-established,  as  well  as  certain  novel  cardiac  biomarkers,  and  their  role  in  
recognizing asymptomatic CT, in order to gain deeper insight into their diagnostic utility., Klinička  efikasnost  hemioterapije,  kao  priznatog  terapeutskog  pristupa  malignim 
bolestima, obično ima određena ograničenja zbog svoje kardiotoksičnosti (KT), te posledične 
kardiomiopatije, pa čak i srčane insuficijencije. KT se definiše kao svaka povreda miokarda 
povezana  s  lečenjem  raka,  uzimajući  u  obzir  hemioterapiju,  radioterapiju,  biološku  ili 
imunoterapiju,  kao  i  sam  karcinom,  te  predstavlja veliki  izazov  za  kliničare 
u  svakodnevnoj  
praksi. Širok spektar faktora povezanih s hemioterapijom (vrsta leka, doza tokom svakog ciklusa, 
kumulativna doza, raspored, način primene, kombinacija s drugim kardiotoksičnim lekovima ili 
povezanost s radioterapijom) i karakteristike bolesnika (dob, prisutnost faktora kardiovaskularnog 
rizika, prethodne kardiovaskularne bolesti), odlučujući su faktori koji utiču na učestalost KT. Za 
praćenje KT koriste se radiološke metode za morfološko i funkcionalno praćenje srčanog mišića. 
Potraga za dij
agnostičkim alatima za rano otkrivanje KT od velikog je značaja. U skladu s tim, 
merenje nekih srčanih biomarkera kao rane determinante povrede miokarda našlo je svoje mesto 
u kliničkim okruženjima. Stoga 
će u ovom preglednom članku posebna pažnja biti po
sve
ć
ena 
nekim  dobro  utvrđenim,  kao  i  nekim  novim  srčanim  biomarkerima,  i  njihovoj  ulozi  u 
prepoznavanju asimptomatske KT, kako bi se stekao dublji uvid u njihovu dijagnostičku korisnost 
i neželjene efekte lekova koji se primenjuju u terapiji karcinoma.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Cardiotoxicity: Importance of biomarkers, Kardiotoksičnost: Važnost biomarkera",
volume = "73",
number = "1",
pages = "1-16",
doi = "10.5937/arhfarm73-40534"
}

Kostadinović, J., Popadić, V., Klašnja, S., Klisić, A., Kotur-Stevuljević, J., Andrić, Z.,& Zdravković, M.. (2023). Cardiotoxicity: Importance of biomarkers. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 73(1), 1-16.
https://doi.org/10.5937/arhfarm73-40534

Kostadinović J, Popadić V, Klašnja S, Klisić A, Kotur-Stevuljević J, Andrić Z, Zdravković M. Cardiotoxicity: Importance of biomarkers. in Arhiv za farmaciju. 2023;73(1):1-16.
doi:10.5937/arhfarm73-40534 .

Kostadinović, Jelena, Popadić, Višeslav, Klašnja, Slobodan, Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Andrić, Zoran, Zdravković, Marija, "Cardiotoxicity: Importance of biomarkers" in Arhiv za farmaciju, 73, no. 1 (2023):1-16,
https://doi.org/10.5937/arhfarm73-40534 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Radoman Vujačić, Irena
AU  - Munjas, Jelena
AU  - Ninić, Ana
AU  - Kotur-Stevuljević, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4247
AB  - In parallel with the rapid growth of obesity, there is also an increase in the prevalence of type 2 diabetes mellitus (T2D) worldwide. Due to its compli- cations, cardiovascular diseases are the leading cause of death in those patients. In the last two decades, special attention has been given to ox- idative stress and inflammation, as the underlying mechanisms related to T2D occurrence and progression. Moreover, micro-ribonucleic acids (miRNAs) as new genetic biomarkers take an important place in the investigation of different metabolic pathways of insulin signaling. In this review article, we discuss microRNA modulation with oxidative stress and inflammation in pa- tients with T2D. Better insight into the novel potential therapeutic targets for treatment of diabetes and its complications is of utmost importance for public health.
PB  - Termedia Publishing House Ltd.
T2  - Archives of Medical Science
T1  - Micro-ribonucleic acid modulation with oxidative stress and inflammation in patients with type 2 diabetes mellitus - a review article
VL  - 18
IS  - 4
SP  - 870
EP  - 880
DO  - 10.5114/aoms/146796
ER  - 

@article{
author = "Klisić, Aleksandra and Radoman Vujačić, Irena and Munjas, Jelena and Ninić, Ana and Kotur-Stevuljević, Jelena",
year = "2022",
abstract = "In parallel with the rapid growth of obesity, there is also an increase in the prevalence of type 2 diabetes mellitus (T2D) worldwide. Due to its compli- cations, cardiovascular diseases are the leading cause of death in those patients. In the last two decades, special attention has been given to ox- idative stress and inflammation, as the underlying mechanisms related to T2D occurrence and progression. Moreover, micro-ribonucleic acids (miRNAs) as new genetic biomarkers take an important place in the investigation of different metabolic pathways of insulin signaling. In this review article, we discuss microRNA modulation with oxidative stress and inflammation in pa- tients with T2D. Better insight into the novel potential therapeutic targets for treatment of diabetes and its complications is of utmost importance for public health.",
publisher = "Termedia Publishing House Ltd.",
journal = "Archives of Medical Science",
title = "Micro-ribonucleic acid modulation with oxidative stress and inflammation in patients with type 2 diabetes mellitus - a review article",
volume = "18",
number = "4",
pages = "870-880",
doi = "10.5114/aoms/146796"
}

Klisić, A., Radoman Vujačić, I., Munjas, J., Ninić, A.,& Kotur-Stevuljević, J.. (2022). Micro-ribonucleic acid modulation with oxidative stress and inflammation in patients with type 2 diabetes mellitus - a review article. in Archives of Medical Science
Termedia Publishing House Ltd.., 18(4), 870-880.
https://doi.org/10.5114/aoms/146796

Klisić A, Radoman Vujačić I, Munjas J, Ninić A, Kotur-Stevuljević J. Micro-ribonucleic acid modulation with oxidative stress and inflammation in patients with type 2 diabetes mellitus - a review article. in Archives of Medical Science. 2022;18(4):870-880.
doi:10.5114/aoms/146796 .

Klisić, Aleksandra, Radoman Vujačić, Irena, Munjas, Jelena, Ninić, Ana, Kotur-Stevuljević, Jelena, "Micro-ribonucleic acid modulation with oxidative stress and inflammation in patients with type 2 diabetes mellitus - a review article" in Archives of Medical Science, 18, no. 4 (2022):870-880,
https://doi.org/10.5114/aoms/146796 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Ninić, Ana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4188
AB  - Due to the increased prevalence of obesity-related complications, especially type 2 diabetes
mellitus (DM2), great attention has been paid to the variety of adipokines and cytokines, i.e.
biomarkers, which are secreted by the enlarged visceral adipose tissue. Those pro-inflammatory
mediators diminish insulin sensitivity via impairing insulin signalling pathways. If these
processes persist, insulin resistance and DM2 occur, with a typical finding of low-grade chronic
inflammation. The current review focuses on some hematological indices that reflect the
inflammation level, such as white blood cell count, its subsets, and derived indexes. Those
parameters are easy to measure, cost-effective, and widely available in a primary care setting. A
deeper knowledge of the changes in the mentioned hematological parameters in DM2, in addition
to glucoregulation biomarkers, may enable physicians to act promptly when patients with this
metabolic disorder are concerned.
AB  - Zbog povećane prevalence komplikacija povezanih sa gojaznošću, naročito diabetes mellitus-a tip (DM2), posebna pažnja se posvećuje različitim adipokinima i citokinima, tj. biomarkerima koje luči uvećano visceralno masno tkivo. Pomenuti medijatori inflamacije smanjuju insulinsku senzitivnost vršeći uticaj na signalne puteve insulina. Ukoliko ovi procesi potraju duže dolazi do pojave insulinske rezistencije i DM2, sa tipičnim nalazom hronične inflamacije niskog stepena. Ovaj revijalni članak akcenat stavlja na određene hematološke parametre koji odražavaju stepen inflamacije, kao što je broj leukocita, njihove podvrste, kao i indeksi izvedeni iz istih. Ovi parametri su lako merljivi, ekonomski isplativi i široko dostupni u ambulantama primarne zdravstvene zaštite. Bolje poznavanje promena navedenih hematoloških parametara u DM2, pored biomarkera glikoregulacije, može omogućiti lekarima pravovremenu reakciju kada se radi o pacijentima sa ovim metaboličkim poremećajem.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - White blood cell count, its subsets, and their indexes in type 2 diabetes mellitus
T1  - Ukupan broj leukocita, diferencijalna krvna slika i njihovi indeksi u diabetes mellitus-u tip 2
VL  - 72
IS  - 2
SP  - 193
EP  - 199
DO  - 10.5937/arhfarm72-36386
ER  - 

@article{
author = "Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Ninić, Ana",
year = "2022",
abstract = "Due to the increased prevalence of obesity-related complications, especially type 2 diabetes
mellitus (DM2), great attention has been paid to the variety of adipokines and cytokines, i.e.
biomarkers, which are secreted by the enlarged visceral adipose tissue. Those pro-inflammatory
mediators diminish insulin sensitivity via impairing insulin signalling pathways. If these
processes persist, insulin resistance and DM2 occur, with a typical finding of low-grade chronic
inflammation. The current review focuses on some hematological indices that reflect the
inflammation level, such as white blood cell count, its subsets, and derived indexes. Those
parameters are easy to measure, cost-effective, and widely available in a primary care setting. A
deeper knowledge of the changes in the mentioned hematological parameters in DM2, in addition
to glucoregulation biomarkers, may enable physicians to act promptly when patients with this
metabolic disorder are concerned., Zbog povećane prevalence komplikacija povezanih sa gojaznošću, naročito diabetes mellitus-a tip (DM2), posebna pažnja se posvećuje različitim adipokinima i citokinima, tj. biomarkerima koje luči uvećano visceralno masno tkivo. Pomenuti medijatori inflamacije smanjuju insulinsku senzitivnost vršeći uticaj na signalne puteve insulina. Ukoliko ovi procesi potraju duže dolazi do pojave insulinske rezistencije i DM2, sa tipičnim nalazom hronične inflamacije niskog stepena. Ovaj revijalni članak akcenat stavlja na određene hematološke parametre koji odražavaju stepen inflamacije, kao što je broj leukocita, njihove podvrste, kao i indeksi izvedeni iz istih. Ovi parametri su lako merljivi, ekonomski isplativi i široko dostupni u ambulantama primarne zdravstvene zaštite. Bolje poznavanje promena navedenih hematoloških parametara u DM2, pored biomarkera glikoregulacije, može omogućiti lekarima pravovremenu reakciju kada se radi o pacijentima sa ovim metaboličkim poremećajem.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "White blood cell count, its subsets, and their indexes in type 2 diabetes mellitus, Ukupan broj leukocita, diferencijalna krvna slika i njihovi indeksi u diabetes mellitus-u tip 2",
volume = "72",
number = "2",
pages = "193-199",
doi = "10.5937/arhfarm72-36386"
}

Klisić, A., Kotur-Stevuljević, J.,& Ninić, A.. (2022). White blood cell count, its subsets, and their indexes in type 2 diabetes mellitus. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 72(2), 193-199.
https://doi.org/10.5937/arhfarm72-36386

Klisić A, Kotur-Stevuljević J, Ninić A. White blood cell count, its subsets, and their indexes in type 2 diabetes mellitus. in Arhiv za farmaciju. 2022;72(2):193-199.
doi:10.5937/arhfarm72-36386 .

Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Ninić, Ana, "White blood cell count, its subsets, and their indexes in type 2 diabetes mellitus" in Arhiv za farmaciju, 72, no. 2 (2022):193-199,
https://doi.org/10.5937/arhfarm72-36386 . .

TY  - CONF
AU  - Klisić, Aleksandra
AU  - Ninić, Ana
AU  - Kotur-Stevuljević, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5587
AB  - Prediabetes and type 2 diabetes mellitus (T2DM) with good glycemic control are not explored thoroughly in relationship with oxidative stress (OS). ...
PB  - Berlin • Boston • Walter de Gruyter
C3  - Clinical Chemistry and Laboratory Medicine
T1  - Serum pro-oxidant-antioxidant balance levels are independently and inversely associated with type 2 diabetes in adult population
VL  - 59
IS  - Special Suppl
SP  - S370
EP  - S370
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5587
ER  - 

@conference{
author = "Klisić, Aleksandra and Ninić, Ana and Kotur-Stevuljević, Jelena",
year = "2021",
abstract = "Prediabetes and type 2 diabetes mellitus (T2DM) with good glycemic control are not explored thoroughly in relationship with oxidative stress (OS). ...",
publisher = "Berlin • Boston • Walter de Gruyter",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Serum pro-oxidant-antioxidant balance levels are independently and inversely associated with type 2 diabetes in adult population",
volume = "59",
number = "Special Suppl",
pages = "S370-S370",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5587"
}

Klisić, A., Ninić, A.,& Kotur-Stevuljević, J.. (2021). Serum pro-oxidant-antioxidant balance levels are independently and inversely associated with type 2 diabetes in adult population. in Clinical Chemistry and Laboratory Medicine
Berlin • Boston • Walter de Gruyter., 59(Special Suppl), S370-S370.
https://hdl.handle.net/21.15107/rcub_farfar_5587

Klisić A, Ninić A, Kotur-Stevuljević J. Serum pro-oxidant-antioxidant balance levels are independently and inversely associated with type 2 diabetes in adult population. in Clinical Chemistry and Laboratory Medicine. 2021;59(Special Suppl):S370-S370.
https://hdl.handle.net/21.15107/rcub_farfar_5587 .

Klisić, Aleksandra, Ninić, Ana, Kotur-Stevuljević, Jelena, "Serum pro-oxidant-antioxidant balance levels are independently and inversely associated with type 2 diabetes in adult population" in Clinical Chemistry and Laboratory Medicine, 59, no. Special Suppl (2021):S370-S370,
https://hdl.handle.net/21.15107/rcub_farfar_5587 .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Ninić, Ana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5570
AB  - Objective: Given the fact that pathophysiological background of non-alcoholic fatty liver disease is not completely
elucidated, we aimed to explore the relationship between dyslipidemia, inflammation and oxidative stress with
hepatic steatosis index (HSI) in the cohort of adolescent population in Montenegro.
Patients and Methods: A total of 136 adolescents participated in this cross-sectional study. Anthropometric and
biochemical markers were provided. HSI was calculated. Associations of biochemical parameters with HSI were
tested using univariable and multivariable ordinal regression analysis for HSI tertiles as dependent variable.
Results: Adjusted odds for uric acid (OR=2.641, P=0.007) and for triglycerides, (OR=5.275, P=0.008) showed
their highly significant positive associations with HSI. On the contrary, adjusted odds for bilirubin (OR=0.923,
P=0.015), indicated its significant negative independent association with HSI. Although C-reactive protein
correlated positively with HSI in univariable analysis (OR=1.962, P<0.001), it lost its independent prediction for
HSI in multivariable analysis (OR=1.442, P=0.130).
Conclusion: Serum uric acid, triglycerides and total bilirubin are associated with HSI in adolescents. Longitudinal
studies are needed to confirm the causal relationship between mentioned biomarkers and hepatic steatosis and to
further explore its diagnostic potential in NAFLD in young population.
AB  - Cilj: S obzirom na činjenicu da patofiziološki aspekt nealkoholne steatoze jetre nije u potpunosti razjašnjen, cilj
studije je bio da se ispita povezanost dislipidemije, inflamacije i oksidativnog stresa sa Indeksom masne jetre (IMJ)
u kohorti adolescentne populacije u Crnoj Gori.
Pacijenti i Metode: Ukupno 136 adolescenata je učestvovalo u studiji preseka. Antropometrijski i biohemijski
marker su mereni. IMJ je izračunat. Povezanost biohemijskih parametara sa IMJ ispitana je univarijantnom i
multivarijantnom ordinalnom regresionom analizom, sa tercilnim vrednostima IMJ kao zavisnom varijablom.
Rezultati: Prilagođene odds vrednosti za mokraćnu kiselinu (OR=2,641, P=0,007) i trigliceride (OR=5,275,
P=0,008) pokazali su visoko značajnu pozitivnu povezanost sa IMJ. Suprotno tome, prilagođene odds vrednosti za
bilirubin (OR=0,923, P=0,015) pokazale su značajnu negativnu povezanost sa IMJ. Premda su vrednosti C-
reaktivnog proteina pozitivno korelirale sa IMJ u univarijantnoj (OR=1,962, P<0,001), isti je izgubio nezavisnu
predikciju za IMJ u multivarijantnoj analizi (OR=1,442, P=0,130).
Zaključak: Serumske vrednosti mokraćne kiseline, triglicerida i ukupnog bilirubina su povezane sa IMJ u
adolescenata. Longitudinalne studije su potrebne da potvrde uzročnu povezanost između pomenutih biomarkera i
steatoze jetre, kao i da dalje ispitaju njihov dijagnostički potencijal za ovo oboljenje u mlađoj populaciji.
PB  - Udruženje preventivne pedijatrije Srbije
T2  - Preventivna pedijatrija
T1  - Serum uric acid, triglycerides and total bilirubin are associated with Hepatic Steatosis Index in adolescent population
T1  - Serumske vrednosti mokraćne kiseline, triglicerida i ukupnog bilirubina su povezane sa Indeksom masne jetre u adolescentnoj populaciji
VL  - 6
IS  - 1-2
SP  - 71
EP  - 76
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5570
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Ninić, Ana",
year = "2020",
abstract = "Objective: Given the fact that pathophysiological background of non-alcoholic fatty liver disease is not completely
elucidated, we aimed to explore the relationship between dyslipidemia, inflammation and oxidative stress with
hepatic steatosis index (HSI) in the cohort of adolescent population in Montenegro.
Patients and Methods: A total of 136 adolescents participated in this cross-sectional study. Anthropometric and
biochemical markers were provided. HSI was calculated. Associations of biochemical parameters with HSI were
tested using univariable and multivariable ordinal regression analysis for HSI tertiles as dependent variable.
Results: Adjusted odds for uric acid (OR=2.641, P=0.007) and for triglycerides, (OR=5.275, P=0.008) showed
their highly significant positive associations with HSI. On the contrary, adjusted odds for bilirubin (OR=0.923,
P=0.015), indicated its significant negative independent association with HSI. Although C-reactive protein
correlated positively with HSI in univariable analysis (OR=1.962, P<0.001), it lost its independent prediction for
HSI in multivariable analysis (OR=1.442, P=0.130).
Conclusion: Serum uric acid, triglycerides and total bilirubin are associated with HSI in adolescents. Longitudinal
studies are needed to confirm the causal relationship between mentioned biomarkers and hepatic steatosis and to
further explore its diagnostic potential in NAFLD in young population., Cilj: S obzirom na činjenicu da patofiziološki aspekt nealkoholne steatoze jetre nije u potpunosti razjašnjen, cilj
studije je bio da se ispita povezanost dislipidemije, inflamacije i oksidativnog stresa sa Indeksom masne jetre (IMJ)
u kohorti adolescentne populacije u Crnoj Gori.
Pacijenti i Metode: Ukupno 136 adolescenata je učestvovalo u studiji preseka. Antropometrijski i biohemijski
marker su mereni. IMJ je izračunat. Povezanost biohemijskih parametara sa IMJ ispitana je univarijantnom i
multivarijantnom ordinalnom regresionom analizom, sa tercilnim vrednostima IMJ kao zavisnom varijablom.
Rezultati: Prilagođene odds vrednosti za mokraćnu kiselinu (OR=2,641, P=0,007) i trigliceride (OR=5,275,
P=0,008) pokazali su visoko značajnu pozitivnu povezanost sa IMJ. Suprotno tome, prilagođene odds vrednosti za
bilirubin (OR=0,923, P=0,015) pokazale su značajnu negativnu povezanost sa IMJ. Premda su vrednosti C-
reaktivnog proteina pozitivno korelirale sa IMJ u univarijantnoj (OR=1,962, P<0,001), isti je izgubio nezavisnu
predikciju za IMJ u multivarijantnoj analizi (OR=1,442, P=0,130).
Zaključak: Serumske vrednosti mokraćne kiseline, triglicerida i ukupnog bilirubina su povezane sa IMJ u
adolescenata. Longitudinalne studije su potrebne da potvrde uzročnu povezanost između pomenutih biomarkera i
steatoze jetre, kao i da dalje ispitaju njihov dijagnostički potencijal za ovo oboljenje u mlađoj populaciji.",
publisher = "Udruženje preventivne pedijatrije Srbije",
journal = "Preventivna pedijatrija",
title = "Serum uric acid, triglycerides and total bilirubin are associated with Hepatic Steatosis Index in adolescent population, Serumske vrednosti mokraćne kiseline, triglicerida i ukupnog bilirubina su povezane sa Indeksom masne jetre u adolescentnoj populaciji",
volume = "6",
number = "1-2",
pages = "71-76",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5570"
}

Klisić, A., Kavarić, N.,& Ninić, A.. (2020). Serum uric acid, triglycerides and total bilirubin are associated with Hepatic Steatosis Index in adolescent population. in Preventivna pedijatrija
Udruženje preventivne pedijatrije Srbije., 6(1-2), 71-76.
https://hdl.handle.net/21.15107/rcub_farfar_5570

Klisić A, Kavarić N, Ninić A. Serum uric acid, triglycerides and total bilirubin are associated with Hepatic Steatosis Index in adolescent population. in Preventivna pedijatrija. 2020;6(1-2):71-76.
https://hdl.handle.net/21.15107/rcub_farfar_5570 .

Klisić, Aleksandra, Kavarić, Nebojša, Ninić, Ana, "Serum uric acid, triglycerides and total bilirubin are associated with Hepatic Steatosis Index in adolescent population" in Preventivna pedijatrija, 6, no. 1-2 (2020):71-76,
https://hdl.handle.net/21.15107/rcub_farfar_5570 .