TY  - CONF
AU  - Ivanišević, Jasmina
AU  - Ardalić, Daniela
AU  - Banjac, Gorica
AU  - Janać, Jelena
AU  - Cabunac, Petar
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Miković, Željko
AU  - Stefanović, Aleksandra
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4361
PB  - Elsevier B.V.
C3  - Free Radical Biology and Medicine
T1  - Antioxidant status in hypertensive disorders of pregnancy
VL  - 177
IS  - Supplement 1
SP  - S116
EP  - S117
DO  - 10.1016/j.freeradbiomed.2021.08.185
ER  - 

@conference{
author = "Ivanišević, Jasmina and Ardalić, Daniela and Banjac, Gorica and Janać, Jelena and Cabunac, Petar and Vekić, Jelena and Zeljković, Aleksandra and Spasojević-Kalimanovska, Vesna and Miković, Željko and Stefanović, Aleksandra",
year = "2021",
publisher = "Elsevier B.V.",
journal = "Free Radical Biology and Medicine",
title = "Antioxidant status in hypertensive disorders of pregnancy",
volume = "177",
number = "Supplement 1",
pages = "S116-S117",
doi = "10.1016/j.freeradbiomed.2021.08.185"
}

Ivanišević, J., Ardalić, D., Banjac, G., Janać, J., Cabunac, P., Vekić, J., Zeljković, A., Spasojević-Kalimanovska, V., Miković, Ž.,& Stefanović, A.. (2021). Antioxidant status in hypertensive disorders of pregnancy. in Free Radical Biology and Medicine
Elsevier B.V.., 177(Supplement 1), S116-S117.
https://doi.org/10.1016/j.freeradbiomed.2021.08.185

Ivanišević J, Ardalić D, Banjac G, Janać J, Cabunac P, Vekić J, Zeljković A, Spasojević-Kalimanovska V, Miković Ž, Stefanović A. Antioxidant status in hypertensive disorders of pregnancy. in Free Radical Biology and Medicine. 2021;177(Supplement 1):S116-S117.
doi:10.1016/j.freeradbiomed.2021.08.185 .

Ivanišević, Jasmina, Ardalić, Daniela, Banjac, Gorica, Janać, Jelena, Cabunac, Petar, Vekić, Jelena, Zeljković, Aleksandra, Spasojević-Kalimanovska, Vesna, Miković, Željko, Stefanović, Aleksandra, "Antioxidant status in hypertensive disorders of pregnancy" in Free Radical Biology and Medicine, 177, no. Supplement 1 (2021):S116-S117,
https://doi.org/10.1016/j.freeradbiomed.2021.08.185 . .

TY  - THES
AU  - Janać, Jelena
PY  - 2021
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=8465
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:24853/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=49296649
UR  - https://nardus.mpn.gov.rs/handle/123456789/18886
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4041
AB  - Metabolizam, struktura i funkcionalnost lipoproteina visoke gustine (high-densitylipoproteins-HDL) su blisko povezani. Procenom kvalitatitvnih karakteristika HDL čestica se možedobiti detaljniji uvid u njihovu ateroprotektivnu aktivnost. U ovom istraživanju su ispitanekarakteristike HDL čestica kod metaboličkog sindroma (MS) i pridruženih stanja koja predstavljajufaktore rizika za razvoj kardiovaskularnih bolesti (KVB). Uvid u remodelovanje HDL čestica jeomogućen određivanjem relativne zastupljenosti pojedinačnih HDL subfrakcija, aktivnosti markeraremodelovanja: lecitin-holesterol-acil transferaze (lecithin–cholesterol acyltransferase-LCAT) iholesterol-estar transfernog proteina (cholesteryl ester transfer protein-CETP), kao i koncentracijeCETP. Antioksidativna funkcija HDL čestica je procenjena određivanjem paraoksonazne aktivnostiparaoksonaze 1 (PON1) i koncentracije PON1 i paraoksonaze 3 (PON3). Stepen oksidativnemodifikacije antiaterogenih lipoproteinskih čestica je ispitan određivanjem koncentracijeoksidovanog HDL (OxHDL). Dodatno su određene koncentracije serumskog amiloida A (SAA),leptina i adiponektina. Radi potvrde prisustva nealkoholne masne bolesti jetre (non-alcoholic fattyliver disease-NAFLD) je izračunat indeks masne jetre (fatty liver index-FLI). Dodatno. karakteristikeHDL čestica su ispitane kod različitih metaboličkih fenotipova gojaznih i ispitanika sa prekomernomtelesnom masom.Kod ispitanika sa MS su utvrđeni: dominacija manjih HDL subfrakcija, povišena aktivnostLCAT i koncentracija CETP. U grupi ispitanika sa MS su takođe uočeni povišena koncentracijaOxHDL i vrednosti odnosa OxHDL/HDL-holesterol. Analizom karakteristika HDL čestica u odnosuna prisustvo pojedinačnih komponenti MS je utvrđeno remodelovanje u korist povećanezastupljenosti malih HDL subfrakcija u kategorijama ispitanika sa sniženom koncentracijom HDLholesterola,hipertrigliceridemijom i povećanim obimom struka. Snižena koncentracija PON3 jeuočena kod ispitanika sa sniženom koncentracijom HDL-holesterola i povećanim obimom struka.Povišene vrednosti odnosa OxHDL/HDL-holesterol su utvrđene u kategorijama ispitanika sasniženom koncentracijom HDL-holesterola, hipertrigliceridemijom i povišenom glukozom našte.Aktivnost LCAT je bila značajan prediktor povišenih vrednosti FLI. Odnos OxHDL/HDL-holesterolje bio značajan prediktor metabolički nezdravog fenotipa u kategorijama gojaznih i ispitanika saprekomernom telesnom masom. Korelacionom analizom u celoj grupi ispitanika je utvrđeno da jeodnos leptin/adiponektin je bio u pozitivnoj korelaciji sa relativnom zastupljenošću malih HDLčestica i negativno sa koncentracijom PON3. Aktivnost LCAT je pozitivno korelirala sakoncentracijom triglicerida, relativnom zastupljenošću malih HDL čestica i odnosomleptin/adiponektin.U ovom istraživanju su utvrđene izmenjene kvalitativne karakteristike HDL čestica kod MS ipridruženih stanja. Dominacija manjih HDL subfrakcija i povišen stepen oksidativne modifikacijeHDL čestica su pokazatelji izmenjenih kvalitativnih odlika HDL čestica u uslovima višestrukihmetaboličkih fakora rizika za KVB koji su prisutni kod MS. Dokazana je pozitivna veza izmeđuaktivnosti LCAT, kao markera remodelovanja HDL čestica, sa faktorima rizika za KVB: prisustvomMS i visokim vrednostima FLI, kao surogat markerom NAFLD. Izmenjene strukturne karakteristikeHDL čestica, izražene kroz povišen stepen oksidativne modifikacije, mogu biti dodatni pokazateljnarušenog metaboličkog zdravlja gojaznih i ispitanika sa prekomernom telesnom masom. Sve ovopokazuje da promenjene kvalitativne osobine antiaterogenih lipoproteina kod MS i srodnih stanjamogu biti dodatni element dislipidemije i faktor rizika za razvoj kardiometaboličkih komplikacija.
AB  - High-density lipoproteins (HDL) metabolism, structure, and functionality are interrelated.Evaluation of HDL qualitative characteristics could give a more detailed insight into itsatheroprotective activity. In this study, we evaluated HDL characteristics in subjects with metabolicsyndrome (MS) and related conditions associated with higher risk for cardiovascular diseases (CVD).HDL particles remodeling was evaluated by estimating the relative proportion of each HDLsubfraction, the activity of remodeling markers: lecithin–cholesterol acyltransferase (LCAT) andcholesteryl ester transfer protein (CETP), and CETP concentration. HDL antioxidative function wasassessed through the determination of paraoxonase activity of paraoxonase 1 (PON1), as well asPON1 and paraoxonase 3 (PON3) concentrations. Oxidative modification of HDL particles wasestimated as oxidatively modified HDL (OxHDL) concentration. Additionally, the concentrations ofserum amyloid A (SAA), leptin and adiponectin were measured. Fatty liver index (FLI) was used asa surrogate marker for the presence of non-alcoholic fatty liver disease (NAFLD). In addition, HDLcharacteristics were evaluated in different metabolic phenotypes in the categories of overweight andobese subjects.Domination of smaller HDL subfractions, elevated LCAT activity, and CETP concentration,as well as increased OxHDL concentration and OxHDL/HDL-cholesterol ratio, were observed insubjects with MS. The analysis of HDL characteristics in the presence of individual MS componentsrevealed remodeling in favor of smaller HDL subfractions in subjects with low HDL-cholesterol,hypertriglyceridemia, and elevated waist circumference. We found lower PON3 concentration insubjects with low HDL-cholesterol and elevated waist circumference. Increased OxHDL/HDLcholesterolratio was found in subjects with low HDL-cholesterol, hypertriglyceridemia, and elevatedfasting glucose. LCAT activity was positively associated with FLI. OxHDL/HDL-cholesterol ratiowas a significant predictor of the metabolically unhealthy phenotype in overweight and obesesubjects. In the entire group of subjects, leptin/adiponectin ratio correlated positively with the relativeproportion of small HDL particles, and negatively with PON3 concentration. LCAT activitycorrelated positively with triglyceride concentration, relative proportion of small HDL particles, andleptin/adiponectin ratio.In this study, altered qualitative HDL characteristics in subjects with MS and relatedconditions were observed. Domination of smaller HDL subfractions and increased degree of HDLoxidative modification in subjects with MS indicate impaired HDL qualitative characteristics in thepresence of multiple metabolic CVD risk factors associated with the presence of MS. LCAT activitywas positively associated with the CVD risk factors: the presence of MS and elevated FLI values i.e.the presence of NAFLD. Altered HDL structural features, observed as an increased degree of HDLoxidative modification, can be an additional indicator of the metabolically unhealthy phenotype ofoverweight and obese subjects. Altered qualitative characteristics of antiatherogenic lipoproteins mayrepresent additional components of dyslipidemia and cardiometabolic diseases risk factor in MS andrelated conditions.
PB  - Универзитет у Београду, Фармацеутски факултет
T2  - Универзитет у Београду
T1  - Ispitivanje kvalitativnih i kvantitativnih karakteristika lipoproteina visoke gustine i njihove povezanosti sa markerima dislipidemije i metaboličkog sindroma:
UR  - https://hdl.handle.net/21.15107/rcub_nardus_18886
ER  - 

@phdthesis{
author = "Janać, Jelena",
year = "2021",
abstract = "Metabolizam, struktura i funkcionalnost lipoproteina visoke gustine (high-densitylipoproteins-HDL) su blisko povezani. Procenom kvalitatitvnih karakteristika HDL čestica se možedobiti detaljniji uvid u njihovu ateroprotektivnu aktivnost. U ovom istraživanju su ispitanekarakteristike HDL čestica kod metaboličkog sindroma (MS) i pridruženih stanja koja predstavljajufaktore rizika za razvoj kardiovaskularnih bolesti (KVB). Uvid u remodelovanje HDL čestica jeomogućen određivanjem relativne zastupljenosti pojedinačnih HDL subfrakcija, aktivnosti markeraremodelovanja: lecitin-holesterol-acil transferaze (lecithin–cholesterol acyltransferase-LCAT) iholesterol-estar transfernog proteina (cholesteryl ester transfer protein-CETP), kao i koncentracijeCETP. Antioksidativna funkcija HDL čestica je procenjena određivanjem paraoksonazne aktivnostiparaoksonaze 1 (PON1) i koncentracije PON1 i paraoksonaze 3 (PON3). Stepen oksidativnemodifikacije antiaterogenih lipoproteinskih čestica je ispitan određivanjem koncentracijeoksidovanog HDL (OxHDL). Dodatno su određene koncentracije serumskog amiloida A (SAA),leptina i adiponektina. Radi potvrde prisustva nealkoholne masne bolesti jetre (non-alcoholic fattyliver disease-NAFLD) je izračunat indeks masne jetre (fatty liver index-FLI). Dodatno. karakteristikeHDL čestica su ispitane kod različitih metaboličkih fenotipova gojaznih i ispitanika sa prekomernomtelesnom masom.Kod ispitanika sa MS su utvrđeni: dominacija manjih HDL subfrakcija, povišena aktivnostLCAT i koncentracija CETP. U grupi ispitanika sa MS su takođe uočeni povišena koncentracijaOxHDL i vrednosti odnosa OxHDL/HDL-holesterol. Analizom karakteristika HDL čestica u odnosuna prisustvo pojedinačnih komponenti MS je utvrđeno remodelovanje u korist povećanezastupljenosti malih HDL subfrakcija u kategorijama ispitanika sa sniženom koncentracijom HDLholesterola,hipertrigliceridemijom i povećanim obimom struka. Snižena koncentracija PON3 jeuočena kod ispitanika sa sniženom koncentracijom HDL-holesterola i povećanim obimom struka.Povišene vrednosti odnosa OxHDL/HDL-holesterol su utvrđene u kategorijama ispitanika sasniženom koncentracijom HDL-holesterola, hipertrigliceridemijom i povišenom glukozom našte.Aktivnost LCAT je bila značajan prediktor povišenih vrednosti FLI. Odnos OxHDL/HDL-holesterolje bio značajan prediktor metabolički nezdravog fenotipa u kategorijama gojaznih i ispitanika saprekomernom telesnom masom. Korelacionom analizom u celoj grupi ispitanika je utvrđeno da jeodnos leptin/adiponektin je bio u pozitivnoj korelaciji sa relativnom zastupljenošću malih HDLčestica i negativno sa koncentracijom PON3. Aktivnost LCAT je pozitivno korelirala sakoncentracijom triglicerida, relativnom zastupljenošću malih HDL čestica i odnosomleptin/adiponektin.U ovom istraživanju su utvrđene izmenjene kvalitativne karakteristike HDL čestica kod MS ipridruženih stanja. Dominacija manjih HDL subfrakcija i povišen stepen oksidativne modifikacijeHDL čestica su pokazatelji izmenjenih kvalitativnih odlika HDL čestica u uslovima višestrukihmetaboličkih fakora rizika za KVB koji su prisutni kod MS. Dokazana je pozitivna veza izmeđuaktivnosti LCAT, kao markera remodelovanja HDL čestica, sa faktorima rizika za KVB: prisustvomMS i visokim vrednostima FLI, kao surogat markerom NAFLD. Izmenjene strukturne karakteristikeHDL čestica, izražene kroz povišen stepen oksidativne modifikacije, mogu biti dodatni pokazateljnarušenog metaboličkog zdravlja gojaznih i ispitanika sa prekomernom telesnom masom. Sve ovopokazuje da promenjene kvalitativne osobine antiaterogenih lipoproteina kod MS i srodnih stanjamogu biti dodatni element dislipidemije i faktor rizika za razvoj kardiometaboličkih komplikacija., High-density lipoproteins (HDL) metabolism, structure, and functionality are interrelated.Evaluation of HDL qualitative characteristics could give a more detailed insight into itsatheroprotective activity. In this study, we evaluated HDL characteristics in subjects with metabolicsyndrome (MS) and related conditions associated with higher risk for cardiovascular diseases (CVD).HDL particles remodeling was evaluated by estimating the relative proportion of each HDLsubfraction, the activity of remodeling markers: lecithin–cholesterol acyltransferase (LCAT) andcholesteryl ester transfer protein (CETP), and CETP concentration. HDL antioxidative function wasassessed through the determination of paraoxonase activity of paraoxonase 1 (PON1), as well asPON1 and paraoxonase 3 (PON3) concentrations. Oxidative modification of HDL particles wasestimated as oxidatively modified HDL (OxHDL) concentration. Additionally, the concentrations ofserum amyloid A (SAA), leptin and adiponectin were measured. Fatty liver index (FLI) was used asa surrogate marker for the presence of non-alcoholic fatty liver disease (NAFLD). In addition, HDLcharacteristics were evaluated in different metabolic phenotypes in the categories of overweight andobese subjects.Domination of smaller HDL subfractions, elevated LCAT activity, and CETP concentration,as well as increased OxHDL concentration and OxHDL/HDL-cholesterol ratio, were observed insubjects with MS. The analysis of HDL characteristics in the presence of individual MS componentsrevealed remodeling in favor of smaller HDL subfractions in subjects with low HDL-cholesterol,hypertriglyceridemia, and elevated waist circumference. We found lower PON3 concentration insubjects with low HDL-cholesterol and elevated waist circumference. Increased OxHDL/HDLcholesterolratio was found in subjects with low HDL-cholesterol, hypertriglyceridemia, and elevatedfasting glucose. LCAT activity was positively associated with FLI. OxHDL/HDL-cholesterol ratiowas a significant predictor of the metabolically unhealthy phenotype in overweight and obesesubjects. In the entire group of subjects, leptin/adiponectin ratio correlated positively with the relativeproportion of small HDL particles, and negatively with PON3 concentration. LCAT activitycorrelated positively with triglyceride concentration, relative proportion of small HDL particles, andleptin/adiponectin ratio.In this study, altered qualitative HDL characteristics in subjects with MS and relatedconditions were observed. Domination of smaller HDL subfractions and increased degree of HDLoxidative modification in subjects with MS indicate impaired HDL qualitative characteristics in thepresence of multiple metabolic CVD risk factors associated with the presence of MS. LCAT activitywas positively associated with the CVD risk factors: the presence of MS and elevated FLI values i.e.the presence of NAFLD. Altered HDL structural features, observed as an increased degree of HDLoxidative modification, can be an additional indicator of the metabolically unhealthy phenotype ofoverweight and obese subjects. Altered qualitative characteristics of antiatherogenic lipoproteins mayrepresent additional components of dyslipidemia and cardiometabolic diseases risk factor in MS andrelated conditions.",
publisher = "Универзитет у Београду, Фармацеутски факултет",
journal = "Универзитет у Београду",
title = "Ispitivanje kvalitativnih i kvantitativnih karakteristika lipoproteina visoke gustine i njihove povezanosti sa markerima dislipidemije i metaboličkog sindroma:",
url = "https://hdl.handle.net/21.15107/rcub_nardus_18886"
}

Janać, J.. (2021). Ispitivanje kvalitativnih i kvantitativnih karakteristika lipoproteina visoke gustine i njihove povezanosti sa markerima dislipidemije i metaboličkog sindroma:. in Универзитет у Београду
Универзитет у Београду, Фармацеутски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_18886

Janać J. Ispitivanje kvalitativnih i kvantitativnih karakteristika lipoproteina visoke gustine i njihove povezanosti sa markerima dislipidemije i metaboličkog sindroma:. in Универзитет у Београду. 2021;.
https://hdl.handle.net/21.15107/rcub_nardus_18886 .

Janać, Jelena, "Ispitivanje kvalitativnih i kvantitativnih karakteristika lipoproteina visoke gustine i njihove povezanosti sa markerima dislipidemije i metaboličkog sindroma:" in Универзитет у Београду (2021),
https://hdl.handle.net/21.15107/rcub_nardus_18886 .

TY  - JOUR
AU  - Janać, Jelena
AU  - Zeljković, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Dimitrijević-Srećković, Vesna
AU  - Vekić, Jelena
AU  - Miljković, Milica
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Ivanišević, Jasmina
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3803
AB  - Background: We evaluated the qualitative characteristics of high-density lipoprotein (HDL) particles in metabolically healthy and unhealthy overweight and obese subjects. Methods: The study involved 115 subject individuals classified as metabolically healthy and unhealthy, as in overweight and obese groups. Commercial enzyme-linked immunosorbent assay (ELISA) kits were used to measure oxidized HDL (OxHDL) and serum amyloid A (SAA) concentrations. Lipoprotein subfractions were separated using nondenaturing gradient gel electrophoresis. Results: An independent association was shown between increased OxHDL/HDL-cholesterol ratio and the occurrence of metabolically unhealthy phenotype in the overweight and obese groups. The OxHDL/HDL-cholesterol ratio showed excellent and acceptable diagnostic accuracy in determination of metabolic health phenotypes (overweight group, AUC = 0.881; obese group, AUC = 0.765). Accumulation of smaller HDL particles in metabolically unhealthy subjects was verified by lipoprotein subfraction analysis. SAA concentrations did not differ significantly between phenotypes. Conclusions: Increased OxHDL/HDL-cholesterol ratio may be a potential indicator of disturbed metabolic health in overweight and obese individuals.
PB  - Oxford University Press
T2  - Lab Medicine
T1  - Increased oxidized high-density lipoprotein/ high-density lipoprotein-cholesterol ratio as a potential indicator of disturbed metabolic health in overweight and obese individuals
VL  - 51
IS  - 1
SP  - 24
EP  - 33
DO  - 10.1093/labmed/lmz017
ER  - 

@article{
author = "Janać, Jelena and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Dimitrijević-Srećković, Vesna and Vekić, Jelena and Miljković, Milica and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Ivanišević, Jasmina and Spasojević-Kalimanovska, Vesna",
year = "2020",
abstract = "Background: We evaluated the qualitative characteristics of high-density lipoprotein (HDL) particles in metabolically healthy and unhealthy overweight and obese subjects. Methods: The study involved 115 subject individuals classified as metabolically healthy and unhealthy, as in overweight and obese groups. Commercial enzyme-linked immunosorbent assay (ELISA) kits were used to measure oxidized HDL (OxHDL) and serum amyloid A (SAA) concentrations. Lipoprotein subfractions were separated using nondenaturing gradient gel electrophoresis. Results: An independent association was shown between increased OxHDL/HDL-cholesterol ratio and the occurrence of metabolically unhealthy phenotype in the overweight and obese groups. The OxHDL/HDL-cholesterol ratio showed excellent and acceptable diagnostic accuracy in determination of metabolic health phenotypes (overweight group, AUC = 0.881; obese group, AUC = 0.765). Accumulation of smaller HDL particles in metabolically unhealthy subjects was verified by lipoprotein subfraction analysis. SAA concentrations did not differ significantly between phenotypes. Conclusions: Increased OxHDL/HDL-cholesterol ratio may be a potential indicator of disturbed metabolic health in overweight and obese individuals.",
publisher = "Oxford University Press",
journal = "Lab Medicine",
title = "Increased oxidized high-density lipoprotein/ high-density lipoprotein-cholesterol ratio as a potential indicator of disturbed metabolic health in overweight and obese individuals",
volume = "51",
number = "1",
pages = "24-33",
doi = "10.1093/labmed/lmz017"
}

Janać, J., Zeljković, A., Jelić-Ivanović, Z., Dimitrijević-Srećković, V., Vekić, J., Miljković, M., Stefanović, A., Kotur-Stevuljević, J., Ivanišević, J.,& Spasojević-Kalimanovska, V.. (2020). Increased oxidized high-density lipoprotein/ high-density lipoprotein-cholesterol ratio as a potential indicator of disturbed metabolic health in overweight and obese individuals. in Lab Medicine
Oxford University Press., 51(1), 24-33.
https://doi.org/10.1093/labmed/lmz017

Janać J, Zeljković A, Jelić-Ivanović Z, Dimitrijević-Srećković V, Vekić J, Miljković M, Stefanović A, Kotur-Stevuljević J, Ivanišević J, Spasojević-Kalimanovska V. Increased oxidized high-density lipoprotein/ high-density lipoprotein-cholesterol ratio as a potential indicator of disturbed metabolic health in overweight and obese individuals. in Lab Medicine. 2020;51(1):24-33.
doi:10.1093/labmed/lmz017 .

Janać, Jelena, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Dimitrijević-Srećković, Vesna, Vekić, Jelena, Miljković, Milica, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Ivanišević, Jasmina, Spasojević-Kalimanovska, Vesna, "Increased oxidized high-density lipoprotein/ high-density lipoprotein-cholesterol ratio as a potential indicator of disturbed metabolic health in overweight and obese individuals" in Lab Medicine, 51, no. 1 (2020):24-33,
https://doi.org/10.1093/labmed/lmz017 . .

TY  - JOUR
AU  - Vekić, Jelena
AU  - Ivanišević, Jasmina
AU  - Zeljković, Aleksandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Mihajlović, Marija
AU  - Janać, Jelena
AU  - Vujčić, Sanja
AU  - Miljković, Milica
AU  - Zujović, Dejan
AU  - Kotur-Stevuljević, Jelena
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3746
AB  - Background:Propolis  and  N-acetylcysteine  have  positiveimpact  on  respiratory  tract  health.  Also,  it  has  been  sug-gested that they have beneficial effects on serum lipid andoxidative  stress  status,  but  the  available  data  are  limitedand  mostly  gained  from  animal  models.  In  this  study  weevaluated the effects of propolis and N-acetylcysteine sup-plementation  (PropoMucil®)  on  lipid  status,  lipoproteinsubclasses  distribution  and  paraoxonase  1  activity  in  sub-jects with acute respiratory infection.Methods:Twenty  subjects  with  acute  respiratory  infectionwere included. PropoMucil®granules for oral solution (80mg of dry propolis extract and 200 mg of N-acetylcysteine)were administered tree times per day for ten days. Serumlipid  profile,  paraoxonase  1  activity  and  low-density  andhigh-density  lipoprotein  size  and  subclasses  distributionwere assessed at baseline and after supplementation.Results:Following ten days of supplementation lipid statusremained  unchanged,  but  a  significant  increase  of  low-density lipoprotein particle size and proportion of high-den-sity   lipoprotein   3a   particles   were   found   (P<0.05).Moreover, supplementation with PropoMucil®significantlyimproved  high-density  lipoprotein  particles  distribution, particularly  in  those  who  smoke.  There  was  a  moderateincrease  of  paraoxonase  1  activity,  but  without  statisticalsignificance.Conclusions:The presented study demonstrated that short-term  supplementation  with  PropoMucil®has  beneficialeffects  on  low-density  and  high-density  lipoprotein  sub-classes  distribution  and  paraoxonase  1  activity  in  subjectswith  acute  respiratory  infection  particularly  in  those  whosmoke.
AB  - Uvod: Propolis i N-acetilcistein pozitivno utiču na zdravlje disajnih puteva. Takođe, sugeriše se da oni imaju blagotvorno dejstvo na lipidni i oksidativno-stresni status, ali podaci su ograničeni i dobijeni uglavnom na životinjskim modelima. U ovom istraživanju, procenili smo kombinovani efekat propolisa i N-acetilcisteina (PropoMucil®) na status lipida, raspodelu supklasa lipoproteina i aktivnost paraoksonaze 1 kod pacijenata sa akutnom respiratornom infekcijom (ARI). Metode: Uključeno je 20 ispitanika sa akutnom respiratornom infekcijom. Oralni rastvor praška PropoMucil® (80 mg suvog ekstrakta propolisa i 200 mg N-acetilcisteina) je aplikovan 3 puta dnevno tokom 10 dana. Serumski lipidni profil, aktivnost praoksonaze 1 i veličina i raspodela supfrakcija lipoproteina niske gustine i lipoproteina visoke gustine su određeni pre i nakon suplementacije. Rezultati: Nakon deset dana suplementacije, lipidni status je ostao nepromenjen, ali je utvrđeno značajno povećanje veličine lipoproteina niske gustine i relativnog udela lipoproteina visoke gustine 3a (P <0,05). Pored toga, suplementacija PropoMucil®-om značajno je poboljšala distribuciju lipoproteinskih čestica visoke gustine, posebno kod pacijenata koji puše. Došlo je do umerenog porasta aktivnosti paraoksonaze 1, ali bez statističke značajnosti. Zaključak: Studija je pokazala da kratkotrajna suplementacija PropoMucil®-om ima korisne efekte na distribuciju supklasa lipoproteina niske i visoke gustine i aktivnost paraoksonaze 1 kod ispitanika sa akutnom respiratornom infekcijom, posebno kod onih koji puše.
PB  - Beograd : Društvo medicinskih biohemičara Srbije
T2  - Journal of Medical Biochemistry
T1  - Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection
T1  - Efekat suplementacije propolisom i N-acetilcisteinom na raspodelu lipoproteinskih supklasa i aktivnosti paraoksonaze 1 u osoba sa akutnom respiratornom infekcijom
VL  - 39
IS  - 4
SP  - 467
EP  - 473
DO  - 10.5937/jomb0-24695
ER  - 

@article{
author = "Vekić, Jelena and Ivanišević, Jasmina and Zeljković, Aleksandra and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Mihajlović, Marija and Janać, Jelena and Vujčić, Sanja and Miljković, Milica and Zujović, Dejan and Kotur-Stevuljević, Jelena",
year = "2020",
abstract = "Background:Propolis  and  N-acetylcysteine  have  positiveimpact  on  respiratory  tract  health.  Also,  it  has  been  sug-gested that they have beneficial effects on serum lipid andoxidative  stress  status,  but  the  available  data  are  limitedand  mostly  gained  from  animal  models.  In  this  study  weevaluated the effects of propolis and N-acetylcysteine sup-plementation  (PropoMucil®)  on  lipid  status,  lipoproteinsubclasses  distribution  and  paraoxonase  1  activity  in  sub-jects with acute respiratory infection.Methods:Twenty  subjects  with  acute  respiratory  infectionwere included. PropoMucil®granules for oral solution (80mg of dry propolis extract and 200 mg of N-acetylcysteine)were administered tree times per day for ten days. Serumlipid  profile,  paraoxonase  1  activity  and  low-density  andhigh-density  lipoprotein  size  and  subclasses  distributionwere assessed at baseline and after supplementation.Results:Following ten days of supplementation lipid statusremained  unchanged,  but  a  significant  increase  of  low-density lipoprotein particle size and proportion of high-den-sity   lipoprotein   3a   particles   were   found   (P<0.05).Moreover, supplementation with PropoMucil®significantlyimproved  high-density  lipoprotein  particles  distribution, particularly  in  those  who  smoke.  There  was  a  moderateincrease  of  paraoxonase  1  activity,  but  without  statisticalsignificance.Conclusions:The presented study demonstrated that short-term  supplementation  with  PropoMucil®has  beneficialeffects  on  low-density  and  high-density  lipoprotein  sub-classes  distribution  and  paraoxonase  1  activity  in  subjectswith  acute  respiratory  infection  particularly  in  those  whosmoke., Uvod: Propolis i N-acetilcistein pozitivno utiču na zdravlje disajnih puteva. Takođe, sugeriše se da oni imaju blagotvorno dejstvo na lipidni i oksidativno-stresni status, ali podaci su ograničeni i dobijeni uglavnom na životinjskim modelima. U ovom istraživanju, procenili smo kombinovani efekat propolisa i N-acetilcisteina (PropoMucil®) na status lipida, raspodelu supklasa lipoproteina i aktivnost paraoksonaze 1 kod pacijenata sa akutnom respiratornom infekcijom (ARI). Metode: Uključeno je 20 ispitanika sa akutnom respiratornom infekcijom. Oralni rastvor praška PropoMucil® (80 mg suvog ekstrakta propolisa i 200 mg N-acetilcisteina) je aplikovan 3 puta dnevno tokom 10 dana. Serumski lipidni profil, aktivnost praoksonaze 1 i veličina i raspodela supfrakcija lipoproteina niske gustine i lipoproteina visoke gustine su određeni pre i nakon suplementacije. Rezultati: Nakon deset dana suplementacije, lipidni status je ostao nepromenjen, ali je utvrđeno značajno povećanje veličine lipoproteina niske gustine i relativnog udela lipoproteina visoke gustine 3a (P <0,05). Pored toga, suplementacija PropoMucil®-om značajno je poboljšala distribuciju lipoproteinskih čestica visoke gustine, posebno kod pacijenata koji puše. Došlo je do umerenog porasta aktivnosti paraoksonaze 1, ali bez statističke značajnosti. Zaključak: Studija je pokazala da kratkotrajna suplementacija PropoMucil®-om ima korisne efekte na distribuciju supklasa lipoproteina niske i visoke gustine i aktivnost paraoksonaze 1 kod ispitanika sa akutnom respiratornom infekcijom, posebno kod onih koji puše.",
publisher = "Beograd : Društvo medicinskih biohemičara Srbije",
journal = "Journal of Medical Biochemistry",
title = "Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection, Efekat suplementacije propolisom i N-acetilcisteinom na raspodelu lipoproteinskih supklasa i aktivnosti paraoksonaze 1 u osoba sa akutnom respiratornom infekcijom",
volume = "39",
number = "4",
pages = "467-473",
doi = "10.5937/jomb0-24695"
}

Vekić, J., Ivanišević, J., Zeljković, A., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Mihajlović, M., Janać, J., Vujčić, S., Miljković, M., Zujović, D.,& Kotur-Stevuljević, J.. (2020). Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection. in Journal of Medical Biochemistry
Beograd : Društvo medicinskih biohemičara Srbije., 39(4), 467-473.
https://doi.org/10.5937/jomb0-24695

Vekić J, Ivanišević J, Zeljković A, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Mihajlović M, Janać J, Vujčić S, Miljković M, Zujović D, Kotur-Stevuljević J. Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection. in Journal of Medical Biochemistry. 2020;39(4):467-473.
doi:10.5937/jomb0-24695 .

Vekić, Jelena, Ivanišević, Jasmina, Zeljković, Aleksandra, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Mihajlović, Marija, Janać, Jelena, Vujčić, Sanja, Miljković, Milica, Zujović, Dejan, Kotur-Stevuljević, Jelena, "Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection" in Journal of Medical Biochemistry, 39, no. 4 (2020):467-473,
https://doi.org/10.5937/jomb0-24695 . .

TY  - JOUR
AU  - Janać, Jelena
AU  - Zeljković, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Dimitrijević-Srećković, Vesna
AU  - Miljković, Milica
AU  - Stefanović, Aleksandra
AU  - Munjas, Jelena
AU  - Vekić, Jelena
AU  - Kotur-Stevuljević, Jelena
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3293
AB  - Background: Non-alcoholic fatty liver disease is a frequent ailment with known complications, including those within the cardiovascular system. Associations between several indicators of high-density lipoprotein metabolism and function with clinical and laboratory parameters for the assessment of fatty liver index, a surrogate marker of non-alcoholic fatty liver disease, were evaluated. Methods: The study comprised 130 patients classified according to fatty liver index values: fatty liver index  lt  30, fatty liver index 30–59 (the intermediate group) and fatty liver index ⩾ 60. Lecithin–cholesterol acyltransferase and cholesteryl ester transfer protein activities were determined. Paraoxonase 1 concentration and its activity, paraoxonase 3 concentration and high-density lipoprotein subclass distribution were assessed. Results: Increased lecithin–cholesterol acyltransferase activity correlated with increased fatty liver index (P  lt  0.001). Paraoxonase 3 concentration was lower in the fatty liver index ⩾ 60 group compared with the fatty liver index  lt  30 group (P  lt  0.05). Cholesteryl ester transfer protein activity, paraoxonase 1 concentration and its activity did not significantly differ across the fatty liver index groups. The relative proportion of small-sized high-density lipoprotein 3 subclass was higher in the fatty liver index ⩾ 60 group compared with the other two fatty liver index groups (P  lt  0.01). Lecithin–cholesterol acyltransferase activity positively associated with the fatty liver index ⩾ 60 group and remained significant after adjustment for other potential confounders. Only the triglyceride concentration remained significantly associated with lecithin–cholesterol acyltransferase activity when the parameters that constitute the fatty liver index equation were examined. Conclusions: Higher lecithin–cholesterol acyltransferase activity is associated with elevated fatty liver index values. Significant independent association between triglycerides and lecithin–cholesterol acyltransferase activity might indicate a role of hypertriglyceridaemia in alterations of lecithin–cholesterol acyltransferase activity in individuals with elevated fatty liver index.
PB  - Sage Publications Ltd
T2  - Annals of Clinical Biochemistry
T1  - The association between lecithin–cholesterol acyltransferase activity and fatty liver index
VL  - 56
IS  - 5
SP  - 583
EP  - 592
DO  - 10.1177/0004563219853596
ER  - 

@article{
author = "Janać, Jelena and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Dimitrijević-Srećković, Vesna and Miljković, Milica and Stefanović, Aleksandra and Munjas, Jelena and Vekić, Jelena and Kotur-Stevuljević, Jelena and Spasojević-Kalimanovska, Vesna",
year = "2019",
abstract = "Background: Non-alcoholic fatty liver disease is a frequent ailment with known complications, including those within the cardiovascular system. Associations between several indicators of high-density lipoprotein metabolism and function with clinical and laboratory parameters for the assessment of fatty liver index, a surrogate marker of non-alcoholic fatty liver disease, were evaluated. Methods: The study comprised 130 patients classified according to fatty liver index values: fatty liver index  lt  30, fatty liver index 30–59 (the intermediate group) and fatty liver index ⩾ 60. Lecithin–cholesterol acyltransferase and cholesteryl ester transfer protein activities were determined. Paraoxonase 1 concentration and its activity, paraoxonase 3 concentration and high-density lipoprotein subclass distribution were assessed. Results: Increased lecithin–cholesterol acyltransferase activity correlated with increased fatty liver index (P  lt  0.001). Paraoxonase 3 concentration was lower in the fatty liver index ⩾ 60 group compared with the fatty liver index  lt  30 group (P  lt  0.05). Cholesteryl ester transfer protein activity, paraoxonase 1 concentration and its activity did not significantly differ across the fatty liver index groups. The relative proportion of small-sized high-density lipoprotein 3 subclass was higher in the fatty liver index ⩾ 60 group compared with the other two fatty liver index groups (P  lt  0.01). Lecithin–cholesterol acyltransferase activity positively associated with the fatty liver index ⩾ 60 group and remained significant after adjustment for other potential confounders. Only the triglyceride concentration remained significantly associated with lecithin–cholesterol acyltransferase activity when the parameters that constitute the fatty liver index equation were examined. Conclusions: Higher lecithin–cholesterol acyltransferase activity is associated with elevated fatty liver index values. Significant independent association between triglycerides and lecithin–cholesterol acyltransferase activity might indicate a role of hypertriglyceridaemia in alterations of lecithin–cholesterol acyltransferase activity in individuals with elevated fatty liver index.",
publisher = "Sage Publications Ltd",
journal = "Annals of Clinical Biochemistry",
title = "The association between lecithin–cholesterol acyltransferase activity and fatty liver index",
volume = "56",
number = "5",
pages = "583-592",
doi = "10.1177/0004563219853596"
}

Janać, J., Zeljković, A., Jelić-Ivanović, Z., Dimitrijević-Srećković, V., Miljković, M., Stefanović, A., Munjas, J., Vekić, J., Kotur-Stevuljević, J.,& Spasojević-Kalimanovska, V.. (2019). The association between lecithin–cholesterol acyltransferase activity and fatty liver index. in Annals of Clinical Biochemistry
Sage Publications Ltd., 56(5), 583-592.
https://doi.org/10.1177/0004563219853596

Janać J, Zeljković A, Jelić-Ivanović Z, Dimitrijević-Srećković V, Miljković M, Stefanović A, Munjas J, Vekić J, Kotur-Stevuljević J, Spasojević-Kalimanovska V. The association between lecithin–cholesterol acyltransferase activity and fatty liver index. in Annals of Clinical Biochemistry. 2019;56(5):583-592.
doi:10.1177/0004563219853596 .

Janać, Jelena, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Dimitrijević-Srećković, Vesna, Miljković, Milica, Stefanović, Aleksandra, Munjas, Jelena, Vekić, Jelena, Kotur-Stevuljević, Jelena, Spasojević-Kalimanovska, Vesna, "The association between lecithin–cholesterol acyltransferase activity and fatty liver index" in Annals of Clinical Biochemistry, 56, no. 5 (2019):583-592,
https://doi.org/10.1177/0004563219853596 . .

TY  - JOUR
AU  - Bojanin, Dragana
AU  - Vekić, Jelena
AU  - Milenković, Tatjana
AU  - Vuković, Rade
AU  - Zeljković, Aleksandra
AU  - Stefanović, Aleksandra
AU  - Janać, Jelena
AU  - Ivanišević, Jasmina
AU  - Mitrović, Katarina
AU  - Miljković, Milica
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3326
AB  - Background and aims: Dyslipidemia in type 1 diabetes mellitus (T1DM) is characterised by altered distributions of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses. Recent studies suggested that proprotein convertase subtilisin/kexin 9 (PCSK9) may contribute to the development of dyslipidemia in T1DM. In this cross-sectional study, we investigated the association between PCSK9 and lipoprotein subclasses in young T1DM patients, with respect to glycemic control. Methods: Plasma PCSK9 and lipoprotein subclasses were determined in 207 patients with T1DM (106 boys and 101 girls), aged 13.9 +/- 3.0 years and treated by intensive insulin therapy. Results: Plasma PCSK9 levels significantly increased with worsening of glycemic control (p  lt  0.001). T1DM patients with poor glucoregulation had the highest proportion of small, dense LDL (sdLDL) and smaller HDL particles, as well. PCSK9 was positively associated with markers of glucose homeostasis and serum lipid parameters only in patients with suboptimal/poor glucoregulation. In well-controlled T1DM, plasma PCSK9 level was inversely associated with a relative proportion of sdLDL particles (p  lt  0.01) and this association remained significant in multivariate analysis. In T1DM patients with suboptimal/poor glycemic control, PCSK9 was positively associated with the proportion of the smallest HDL3c particles (p  lt  0.001), but negatively with HDL size (p  lt  0.05). Conclusions: The extent of achieved metabolic control modifies the association between PCSK9 and lipoprotein subclasses in T1DM. Further investigations are needed to reveal whether the observed effects of glycemic control on PCSK9 and sdLDL levels have causal consequences on CVD risk in young patients with T1DM.
PB  - Elsevier Ireland Ltd, Clare
T2  - Atherosclerosis
T1  - Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control
VL  - 280
SP  - 14
EP  - 20
DO  - 10.1016/j.atherosclerosis.2018.11.020
ER  - 

@article{
author = "Bojanin, Dragana and Vekić, Jelena and Milenković, Tatjana and Vuković, Rade and Zeljković, Aleksandra and Stefanović, Aleksandra and Janać, Jelena and Ivanišević, Jasmina and Mitrović, Katarina and Miljković, Milica and Spasojević-Kalimanovska, Vesna",
year = "2019",
abstract = "Background and aims: Dyslipidemia in type 1 diabetes mellitus (T1DM) is characterised by altered distributions of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses. Recent studies suggested that proprotein convertase subtilisin/kexin 9 (PCSK9) may contribute to the development of dyslipidemia in T1DM. In this cross-sectional study, we investigated the association between PCSK9 and lipoprotein subclasses in young T1DM patients, with respect to glycemic control. Methods: Plasma PCSK9 and lipoprotein subclasses were determined in 207 patients with T1DM (106 boys and 101 girls), aged 13.9 +/- 3.0 years and treated by intensive insulin therapy. Results: Plasma PCSK9 levels significantly increased with worsening of glycemic control (p  lt  0.001). T1DM patients with poor glucoregulation had the highest proportion of small, dense LDL (sdLDL) and smaller HDL particles, as well. PCSK9 was positively associated with markers of glucose homeostasis and serum lipid parameters only in patients with suboptimal/poor glucoregulation. In well-controlled T1DM, plasma PCSK9 level was inversely associated with a relative proportion of sdLDL particles (p  lt  0.01) and this association remained significant in multivariate analysis. In T1DM patients with suboptimal/poor glycemic control, PCSK9 was positively associated with the proportion of the smallest HDL3c particles (p  lt  0.001), but negatively with HDL size (p  lt  0.05). Conclusions: The extent of achieved metabolic control modifies the association between PCSK9 and lipoprotein subclasses in T1DM. Further investigations are needed to reveal whether the observed effects of glycemic control on PCSK9 and sdLDL levels have causal consequences on CVD risk in young patients with T1DM.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control",
volume = "280",
pages = "14-20",
doi = "10.1016/j.atherosclerosis.2018.11.020"
}

Bojanin, D., Vekić, J., Milenković, T., Vuković, R., Zeljković, A., Stefanović, A., Janać, J., Ivanišević, J., Mitrović, K., Miljković, M.,& Spasojević-Kalimanovska, V.. (2019). Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 280, 14-20.
https://doi.org/10.1016/j.atherosclerosis.2018.11.020

Bojanin D, Vekić J, Milenković T, Vuković R, Zeljković A, Stefanović A, Janać J, Ivanišević J, Mitrović K, Miljković M, Spasojević-Kalimanovska V. Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control. in Atherosclerosis. 2019;280:14-20.
doi:10.1016/j.atherosclerosis.2018.11.020 .

Bojanin, Dragana, Vekić, Jelena, Milenković, Tatjana, Vuković, Rade, Zeljković, Aleksandra, Stefanović, Aleksandra, Janać, Jelena, Ivanišević, Jasmina, Mitrović, Katarina, Miljković, Milica, Spasojević-Kalimanovska, Vesna, "Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control" in Atherosclerosis, 280 (2019):14-20,
https://doi.org/10.1016/j.atherosclerosis.2018.11.020 . .

TY  - JOUR
AU  - Milanović, Z
AU  - Vekić, Jelena
AU  - Radonjić, V
AU  - Ilić-Božović, A
AU  - Zeljković, Aleksandra
AU  - Janać, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Buch, J
AU  - Chandrashekar, R
AU  - Bojić-Trbojević, Ž
AU  - Hajduković, L
AU  - Christopher, M.M
AU  - Kovačević Filipović, M
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3253
AB  - Background: Babesia canis infection induces a marked acute phase response (APR) that might be associated with alteration in lipid and lipoprotein metabolism and disease prognosis. Hypothesis: Dogs with B. canis-induced APR develop dyslipidemia with altered lipoprotein concentration and morphology. Animals: Twenty-nine client-owned dogs with acute B. canis infection and 10 clinically healthy control dogs. Methods: Observational cross-sectional study. Serum amyloid A (SAA) was measured using ELISA. Cholesterol, phospholipids, and triglycerides were determined biochemically. Lipoproteins were separated using agarose gel electrophoresis. Lipoprotein diameter was assessed by polyacrylamide gradient gel electrophoresis; correlation with ApoA-1 (radioimmunoassay) and SAA was determined. Results: Dogs with B. canis infection had a marked APR (median SAA, 168.3 μg/mL; range, 98.1-716.2 μg/mL) compared with controls (3.2 μg/mL, 2.0-4.2 μg/mL) (P  lt .001). Dogs with B. canis infection had significantly lower median cholesterol (4.79 mmol/L, 1.89-7.64 mmol/L versus 6.15 mmol/L, 4.2-7.4 mmol/L) (P =.02), phospholipid (4.64 mmol/L, 2.6-6.6 mmol/L versus 5.72 mmol/L, 4.68-7.0 mmol/L) (P =.02), and α-lipoproteins (77.5%, 27.7%-93.5% versus 89.2%, 75.1%-93.5%) (P =.04), and higher ApoA-1 (1.36 U, 0.8-2.56 U versus 0.95 U, 0.73-1.54 U) concentrations (P =.02). Serum amyloid A correlated with high-density lipoproteins (HDLs) diameter (rho =.43; P =.03) and ApoA-1 (rho =.63, P  lt .001). Conclusions and Clinical Importance: Major changes associated with B. canis-induced APR in dogs are related to concentration, composition, and morphology of HDL particles pointing to an altered reverse cholesterol transport. Parallel ApoA-1 and SAA concentration increase is a unique still unexplained pathophysiological finding.
PB  - Blackwell Publishing Inc.
T2  - Journal of Veterinary Internal Medicine
T1  - Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs
VL  - 33
IS  - 4
SP  - 1686
EP  - 1694
DO  - 10.1111/jvim.15537
ER  - 

@article{
author = "Milanović, Z and Vekić, Jelena and Radonjić, V and Ilić-Božović, A and Zeljković, Aleksandra and Janać, Jelena and Spasojević-Kalimanovska, Vesna and Buch, J and Chandrashekar, R and Bojić-Trbojević, Ž and Hajduković, L and Christopher, M.M and Kovačević Filipović, M",
year = "2019",
abstract = "Background: Babesia canis infection induces a marked acute phase response (APR) that might be associated with alteration in lipid and lipoprotein metabolism and disease prognosis. Hypothesis: Dogs with B. canis-induced APR develop dyslipidemia with altered lipoprotein concentration and morphology. Animals: Twenty-nine client-owned dogs with acute B. canis infection and 10 clinically healthy control dogs. Methods: Observational cross-sectional study. Serum amyloid A (SAA) was measured using ELISA. Cholesterol, phospholipids, and triglycerides were determined biochemically. Lipoproteins were separated using agarose gel electrophoresis. Lipoprotein diameter was assessed by polyacrylamide gradient gel electrophoresis; correlation with ApoA-1 (radioimmunoassay) and SAA was determined. Results: Dogs with B. canis infection had a marked APR (median SAA, 168.3 μg/mL; range, 98.1-716.2 μg/mL) compared with controls (3.2 μg/mL, 2.0-4.2 μg/mL) (P  lt .001). Dogs with B. canis infection had significantly lower median cholesterol (4.79 mmol/L, 1.89-7.64 mmol/L versus 6.15 mmol/L, 4.2-7.4 mmol/L) (P =.02), phospholipid (4.64 mmol/L, 2.6-6.6 mmol/L versus 5.72 mmol/L, 4.68-7.0 mmol/L) (P =.02), and α-lipoproteins (77.5%, 27.7%-93.5% versus 89.2%, 75.1%-93.5%) (P =.04), and higher ApoA-1 (1.36 U, 0.8-2.56 U versus 0.95 U, 0.73-1.54 U) concentrations (P =.02). Serum amyloid A correlated with high-density lipoproteins (HDLs) diameter (rho =.43; P =.03) and ApoA-1 (rho =.63, P  lt .001). Conclusions and Clinical Importance: Major changes associated with B. canis-induced APR in dogs are related to concentration, composition, and morphology of HDL particles pointing to an altered reverse cholesterol transport. Parallel ApoA-1 and SAA concentration increase is a unique still unexplained pathophysiological finding.",
publisher = "Blackwell Publishing Inc.",
journal = "Journal of Veterinary Internal Medicine",
title = "Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs",
volume = "33",
number = "4",
pages = "1686-1694",
doi = "10.1111/jvim.15537"
}

Milanović, Z., Vekić, J., Radonjić, V., Ilić-Božović, A., Zeljković, A., Janać, J., Spasojević-Kalimanovska, V., Buch, J., Chandrashekar, R., Bojić-Trbojević, Ž., Hajduković, L., Christopher, M.M,& Kovačević Filipović, M.. (2019). Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs. in Journal of Veterinary Internal Medicine
Blackwell Publishing Inc.., 33(4), 1686-1694.
https://doi.org/10.1111/jvim.15537

Milanović Z, Vekić J, Radonjić V, Ilić-Božović A, Zeljković A, Janać J, Spasojević-Kalimanovska V, Buch J, Chandrashekar R, Bojić-Trbojević Ž, Hajduković L, Christopher M, Kovačević Filipović M. Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs. in Journal of Veterinary Internal Medicine. 2019;33(4):1686-1694.
doi:10.1111/jvim.15537 .

Milanović, Z, Vekić, Jelena, Radonjić, V, Ilić-Božović, A, Zeljković, Aleksandra, Janać, Jelena, Spasojević-Kalimanovska, Vesna, Buch, J, Chandrashekar, R, Bojić-Trbojević, Ž, Hajduković, L, Christopher, M.M, Kovačević Filipović, M, "Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs" in Journal of Veterinary Internal Medicine, 33, no. 4 (2019):1686-1694,
https://doi.org/10.1111/jvim.15537 . .

TY  - CONF
AU  - Sopić, Miron
AU  - Mihajlović, Marija
AU  - Ninić, Ana
AU  - Bogavac-Stanojević, Nataša
AU  - Stepanović, Željka
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Janać, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3074
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Adipor1 polymorphism g.202940846g > c (rs7539542) is associated with higher cardiovascular risk in middle-aged population
VL  - 275
SP  - e248
EP  - e248
DO  - 10.1016/j.atherosclerosis.2018.06.788
ER  - 

@conference{
author = "Sopić, Miron and Mihajlović, Marija and Ninić, Ana and Bogavac-Stanojević, Nataša and Stepanović, Željka and Vekić, Jelena and Zeljković, Aleksandra and Janać, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana",
year = "2018",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Adipor1 polymorphism g.202940846g > c (rs7539542) is associated with higher cardiovascular risk in middle-aged population",
volume = "275",
pages = "e248-e248",
doi = "10.1016/j.atherosclerosis.2018.06.788"
}

Sopić, M., Mihajlović, M., Ninić, A., Bogavac-Stanojević, N., Stepanović, Ž., Vekić, J., Zeljković, A., Janać, J., Spasojević-Kalimanovska, V.,& Jelić-Ivanović, Z.. (2018). Adipor1 polymorphism g.202940846g > c (rs7539542) is associated with higher cardiovascular risk in middle-aged population. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 275, e248-e248.
https://doi.org/10.1016/j.atherosclerosis.2018.06.788

Sopić M, Mihajlović M, Ninić A, Bogavac-Stanojević N, Stepanović Ž, Vekić J, Zeljković A, Janać J, Spasojević-Kalimanovska V, Jelić-Ivanović Z. Adipor1 polymorphism g.202940846g > c (rs7539542) is associated with higher cardiovascular risk in middle-aged population. in Atherosclerosis. 2018;275:e248-e248.
doi:10.1016/j.atherosclerosis.2018.06.788 .

Sopić, Miron, Mihajlović, Marija, Ninić, Ana, Bogavac-Stanojević, Nataša, Stepanović, Željka, Vekić, Jelena, Zeljković, Aleksandra, Janać, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, "Adipor1 polymorphism g.202940846g > c (rs7539542) is associated with higher cardiovascular risk in middle-aged population" in Atherosclerosis, 275 (2018):e248-e248,
https://doi.org/10.1016/j.atherosclerosis.2018.06.788 . .

TY  - JOUR
AU  - Stevanović, Milica
AU  - Vekić, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Janać, Jelena
AU  - Stjepanović, Željka
AU  - Zeljković, Dejan
AU  - Trifunović, Bratislav
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3048
AB  - Introduction: Dyslipidaemia contributes to the occurrence of colorectal cancer (CRC). We hypothesized that qualitative changes of lipoproteins are associated with the risk for CRC development. This study analyses low-density lipoprotein (LDL) and high-density lipoprotein (HDL) diameters, as well as distribution of LDL and HDL subclasses in patients with CRC, with an aim to determine whether advanced lipid testing might be useful in predicting the risk for the onset of this malignancy. Materials and methods: This case-control study included 84 patients with newly diagnosed CRC and 92 controls. Gradient gel electrophoresis was applied for separation of lipoprotein subclasses and for LDL and HDL diameters determination. Lipid parameters were measured using routine enzymatic methods. Results: Total cholesterol, HDL and LDL-cholesterol were significantly lower in CRC patients compared to controls (4.47 mmol/L vs. 5.63 mmol/L; 0.99 mmol/L vs. 1.27 mmol/L; 2.90 mmol/L vs. 3.66 mmol/L; P  lt  0.001, respectively). Patients had significantly smaller LDL (25.14 nm vs. 26.92 nm; P  lt  0.001) and HDL diameters (8.76 nm vs. 10.17 nm; P  lt  0.001) and greater proportion of small, dense LDL particles (54.0% vs. 52.9%; P = 0.044) than controls. Decreased LDL and HDL diameters were independent predictors of CRC (OR = 0.5, P = 0.001 and OR = 0.5, P = 0.008, respectively), and alongside with age and HDL-cholesterol concentrations formed the optimal cost-effective model, providing adequate discriminative abilities for CRC (AUC = 0.89) and correct patients classification (81%). Conclusions: Patients with CRC have decreased LDL and HDL diameters and increased proportion of smaller particles. LDL and HDL diameters determination could be useful in assessing the risk for CRC development.
PB  - Croatian Soc Medical Biochemists, Zagreb
T2  - Biochemia Medica
T1  - Significance of LDL and HDL subclasses characterization in the assessment of risk for colorectal cancer development
VL  - 28
IS  - 3
DO  - 10.11613/BM.2018.030713
ER  - 

@article{
author = "Stevanović, Milica and Vekić, Jelena and Bogavac-Stanojević, Nataša and Janać, Jelena and Stjepanović, Željka and Zeljković, Dejan and Trifunović, Bratislav and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra",
year = "2018",
abstract = "Introduction: Dyslipidaemia contributes to the occurrence of colorectal cancer (CRC). We hypothesized that qualitative changes of lipoproteins are associated with the risk for CRC development. This study analyses low-density lipoprotein (LDL) and high-density lipoprotein (HDL) diameters, as well as distribution of LDL and HDL subclasses in patients with CRC, with an aim to determine whether advanced lipid testing might be useful in predicting the risk for the onset of this malignancy. Materials and methods: This case-control study included 84 patients with newly diagnosed CRC and 92 controls. Gradient gel electrophoresis was applied for separation of lipoprotein subclasses and for LDL and HDL diameters determination. Lipid parameters were measured using routine enzymatic methods. Results: Total cholesterol, HDL and LDL-cholesterol were significantly lower in CRC patients compared to controls (4.47 mmol/L vs. 5.63 mmol/L; 0.99 mmol/L vs. 1.27 mmol/L; 2.90 mmol/L vs. 3.66 mmol/L; P  lt  0.001, respectively). Patients had significantly smaller LDL (25.14 nm vs. 26.92 nm; P  lt  0.001) and HDL diameters (8.76 nm vs. 10.17 nm; P  lt  0.001) and greater proportion of small, dense LDL particles (54.0% vs. 52.9%; P = 0.044) than controls. Decreased LDL and HDL diameters were independent predictors of CRC (OR = 0.5, P = 0.001 and OR = 0.5, P = 0.008, respectively), and alongside with age and HDL-cholesterol concentrations formed the optimal cost-effective model, providing adequate discriminative abilities for CRC (AUC = 0.89) and correct patients classification (81%). Conclusions: Patients with CRC have decreased LDL and HDL diameters and increased proportion of smaller particles. LDL and HDL diameters determination could be useful in assessing the risk for CRC development.",
publisher = "Croatian Soc Medical Biochemists, Zagreb",
journal = "Biochemia Medica",
title = "Significance of LDL and HDL subclasses characterization in the assessment of risk for colorectal cancer development",
volume = "28",
number = "3",
doi = "10.11613/BM.2018.030713"
}

Stevanović, M., Vekić, J., Bogavac-Stanojević, N., Janać, J., Stjepanović, Ž., Zeljković, D., Trifunović, B., Spasojević-Kalimanovska, V.,& Zeljković, A.. (2018). Significance of LDL and HDL subclasses characterization in the assessment of risk for colorectal cancer development. in Biochemia Medica
Croatian Soc Medical Biochemists, Zagreb., 28(3).
https://doi.org/10.11613/BM.2018.030713

Stevanović M, Vekić J, Bogavac-Stanojević N, Janać J, Stjepanović Ž, Zeljković D, Trifunović B, Spasojević-Kalimanovska V, Zeljković A. Significance of LDL and HDL subclasses characterization in the assessment of risk for colorectal cancer development. in Biochemia Medica. 2018;28(3).
doi:10.11613/BM.2018.030713 .

Stevanović, Milica, Vekić, Jelena, Bogavac-Stanojević, Nataša, Janać, Jelena, Stjepanović, Željka, Zeljković, Dejan, Trifunović, Bratislav, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, "Significance of LDL and HDL subclasses characterization in the assessment of risk for colorectal cancer development" in Biochemia Medica, 28, no. 3 (2018),
https://doi.org/10.11613/BM.2018.030713 . .

TY  - JOUR
AU  - Bojanin, Dragana
AU  - Milenković, Tatjana
AU  - Vekić, Jelena
AU  - Vuković, Rade
AU  - Zeljković, Aleksandra
AU  - Janać, Jelena
AU  - Ivanišević, Jasmina
AU  - Todorović, Slađana
AU  - Mazibrada, Ilijana
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3153
AB  - Objective: Paediatric patients with type 1 diabetes mellitus (T1DM) frequently develop other autoimmune disorders; most commonly autoimmune thyroiditis (ATD) and celiac disease (CD). In this study we evaluated whether co-existing autoimmune diseases had significant impact on lipid and lipoprotein subclasses, as known cardiovascular risk factors in T1DM. Design and methods: Study included 201 subjects with T1DM (14.1 +/- 2.9 years) and 141 age-and gender-matched controls. ATD was presented in 30 and CD in 15 T1DM patients. Serum lipid parameters were determined by routine laboratory methods and plasma low-density (LDL) and high-density lipoprotein (HDL) subclasses by gradient-gel electrophoresis method. Results: Both groups of T1DM patients with concomitant autoimmune disease had significantly lower HDL-C levels (P  lt  0.05) than the patients with T1DM only, but comparable to control group (P = 0.436). T1DM patients had significantly higher (P  lt  0.001) proportion of small HDL subclasses than controls. Mean value of atherosclerosis index in patients with T1DM + CD was the highest (1.75 +/- 0.86) and it was significantly higher than the index in patients with T1DM only (1.33 +/- 0.51; P  lt  0.05). LDL size did not differ between the groups of T1DM patients and control group (P= 0.619). The size of HDL particles was significantly reduced (P  lt  0.05) in the groups with associated autoimmune diseases. The patients with co-existing autoimmune diseases had higher risk of low HDL-C level (OR: 2.96; P  lt  0.05). Conclusions: The results have shown significant impact of co-existing autoimmune diseases on lipid profile in patients with T1DM. The most prominent changes were found in HDL lipoprotein characteristics in T1DM + CD group.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus
VL  - 54
SP  - 11
EP  - 17
DO  - 10.1016/j.clinbiochem.2018.01.026
ER  - 

@article{
author = "Bojanin, Dragana and Milenković, Tatjana and Vekić, Jelena and Vuković, Rade and Zeljković, Aleksandra and Janać, Jelena and Ivanišević, Jasmina and Todorović, Slađana and Mazibrada, Ilijana and Spasojević-Kalimanovska, Vesna",
year = "2018",
abstract = "Objective: Paediatric patients with type 1 diabetes mellitus (T1DM) frequently develop other autoimmune disorders; most commonly autoimmune thyroiditis (ATD) and celiac disease (CD). In this study we evaluated whether co-existing autoimmune diseases had significant impact on lipid and lipoprotein subclasses, as known cardiovascular risk factors in T1DM. Design and methods: Study included 201 subjects with T1DM (14.1 +/- 2.9 years) and 141 age-and gender-matched controls. ATD was presented in 30 and CD in 15 T1DM patients. Serum lipid parameters were determined by routine laboratory methods and plasma low-density (LDL) and high-density lipoprotein (HDL) subclasses by gradient-gel electrophoresis method. Results: Both groups of T1DM patients with concomitant autoimmune disease had significantly lower HDL-C levels (P  lt  0.05) than the patients with T1DM only, but comparable to control group (P = 0.436). T1DM patients had significantly higher (P  lt  0.001) proportion of small HDL subclasses than controls. Mean value of atherosclerosis index in patients with T1DM + CD was the highest (1.75 +/- 0.86) and it was significantly higher than the index in patients with T1DM only (1.33 +/- 0.51; P  lt  0.05). LDL size did not differ between the groups of T1DM patients and control group (P= 0.619). The size of HDL particles was significantly reduced (P  lt  0.05) in the groups with associated autoimmune diseases. The patients with co-existing autoimmune diseases had higher risk of low HDL-C level (OR: 2.96; P  lt  0.05). Conclusions: The results have shown significant impact of co-existing autoimmune diseases on lipid profile in patients with T1DM. The most prominent changes were found in HDL lipoprotein characteristics in T1DM + CD group.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus",
volume = "54",
pages = "11-17",
doi = "10.1016/j.clinbiochem.2018.01.026"
}

Bojanin, D., Milenković, T., Vekić, J., Vuković, R., Zeljković, A., Janać, J., Ivanišević, J., Todorović, S., Mazibrada, I.,& Spasojević-Kalimanovska, V.. (2018). Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 54, 11-17.
https://doi.org/10.1016/j.clinbiochem.2018.01.026

Bojanin D, Milenković T, Vekić J, Vuković R, Zeljković A, Janać J, Ivanišević J, Todorović S, Mazibrada I, Spasojević-Kalimanovska V. Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus. in Clinical Biochemistry. 2018;54:11-17.
doi:10.1016/j.clinbiochem.2018.01.026 .

Bojanin, Dragana, Milenković, Tatjana, Vekić, Jelena, Vuković, Rade, Zeljković, Aleksandra, Janać, Jelena, Ivanišević, Jasmina, Todorović, Slađana, Mazibrada, Ilijana, Spasojević-Kalimanovska, Vesna, "Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus" in Clinical Biochemistry, 54 (2018):11-17,
https://doi.org/10.1016/j.clinbiochem.2018.01.026 . .

TY  - JOUR
AU  - Bekhet, Osama H.
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Paripović, Dušan
AU  - Gojković, Tamara
AU  - Janać, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Peco-Antić, Amira
AU  - Miloševski-Lomić, Gordana
AU  - Jelić-Ivanović, Zorana
AU  - Stefanović, Aleksandra
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2845
AB  - N Background/aim: Juvenile obesity is associated with several metabolic abnormalities, one of them being atherogenic dyslipidemia. Suboptimal fetal growth is associated with obesity risk in childhood, but also with increased rate of metabolic diseases in later life. This study investigated associations of neonatal data (Apgar score, birth weight and birth length) with low-density lipoprotein and high-density lipoprotein (LDL and HDL) subclasses in a group of obese children, as well as a possible impact of breastfeeding duration on obesity-associated lipoprotein subclasses distributions. Materials and methods: We included 42 obese children, aged 14.2 +/- 2.1 years. LDL and HDL subfractions were separated by gradient gel electrophoresis and biochemical parameters were assessed by routine methods. Results: Compared with obese children with Apgar >= 9, the group with Apgar  lt  9 had significantly higher percentages of small, dense LDL particles (P  lt  0.05), due to reduced LDL I (P  lt  0.01) and increased LDL III subclasses (P  lt  0.05). Birth weight was positively associated with the proportions of LDL I particles (P  lt  0.001), whereas birth height positively correlated with the amount of HDL 2b subclasses (P  lt  0.05). The group of never or less than 3 months breastfed children had significantly smaller LDL size (P  lt  0.01) and lower proportion of HDL 2a particles (P  lt  0.05) than their >= 3 months breastfed peers. Conclusion: The results showed significant associations of neonatal characteristics with LDL and HDL particle distributions in obese children. In addition, our results point toward positive aspects of longer breastfeeding duration on lipoprotein particle distributions in obese children.
PB  - Tubitak Scientific & Technical Research Council Turkey, Ankara
T2  - Upsala Journal of Medical Sciences
T1  - Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity
VL  - 47
IS  - 6
SP  - 1804
EP  - 1812
DO  - 10.3906/sag-1702-164
ER  - 

@article{
author = "Bekhet, Osama H. and Vekić, Jelena and Zeljković, Aleksandra and Paripović, Dušan and Gojković, Tamara and Janać, Jelena and Spasojević-Kalimanovska, Vesna and Peco-Antić, Amira and Miloševski-Lomić, Gordana and Jelić-Ivanović, Zorana and Stefanović, Aleksandra",
year = "2017",
abstract = "N Background/aim: Juvenile obesity is associated with several metabolic abnormalities, one of them being atherogenic dyslipidemia. Suboptimal fetal growth is associated with obesity risk in childhood, but also with increased rate of metabolic diseases in later life. This study investigated associations of neonatal data (Apgar score, birth weight and birth length) with low-density lipoprotein and high-density lipoprotein (LDL and HDL) subclasses in a group of obese children, as well as a possible impact of breastfeeding duration on obesity-associated lipoprotein subclasses distributions. Materials and methods: We included 42 obese children, aged 14.2 +/- 2.1 years. LDL and HDL subfractions were separated by gradient gel electrophoresis and biochemical parameters were assessed by routine methods. Results: Compared with obese children with Apgar >= 9, the group with Apgar  lt  9 had significantly higher percentages of small, dense LDL particles (P  lt  0.05), due to reduced LDL I (P  lt  0.01) and increased LDL III subclasses (P  lt  0.05). Birth weight was positively associated with the proportions of LDL I particles (P  lt  0.001), whereas birth height positively correlated with the amount of HDL 2b subclasses (P  lt  0.05). The group of never or less than 3 months breastfed children had significantly smaller LDL size (P  lt  0.01) and lower proportion of HDL 2a particles (P  lt  0.05) than their >= 3 months breastfed peers. Conclusion: The results showed significant associations of neonatal characteristics with LDL and HDL particle distributions in obese children. In addition, our results point toward positive aspects of longer breastfeeding duration on lipoprotein particle distributions in obese children.",
publisher = "Tubitak Scientific & Technical Research Council Turkey, Ankara",
journal = "Upsala Journal of Medical Sciences",
title = "Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity",
volume = "47",
number = "6",
pages = "1804-1812",
doi = "10.3906/sag-1702-164"
}

Bekhet, O. H., Vekić, J., Zeljković, A., Paripović, D., Gojković, T., Janać, J., Spasojević-Kalimanovska, V., Peco-Antić, A., Miloševski-Lomić, G., Jelić-Ivanović, Z.,& Stefanović, A.. (2017). Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity. in Upsala Journal of Medical Sciences
Tubitak Scientific & Technical Research Council Turkey, Ankara., 47(6), 1804-1812.
https://doi.org/10.3906/sag-1702-164

Bekhet OH, Vekić J, Zeljković A, Paripović D, Gojković T, Janać J, Spasojević-Kalimanovska V, Peco-Antić A, Miloševski-Lomić G, Jelić-Ivanović Z, Stefanović A. Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity. in Upsala Journal of Medical Sciences. 2017;47(6):1804-1812.
doi:10.3906/sag-1702-164 .

Bekhet, Osama H., Vekić, Jelena, Zeljković, Aleksandra, Paripović, Dušan, Gojković, Tamara, Janać, Jelena, Spasojević-Kalimanovska, Vesna, Peco-Antić, Amira, Miloševski-Lomić, Gordana, Jelić-Ivanović, Zorana, Stefanović, Aleksandra, "Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity" in Upsala Journal of Medical Sciences, 47, no. 6 (2017):1804-1812,
https://doi.org/10.3906/sag-1702-164 . .

TY  - JOUR
AU  - Bekhet, Osama H.
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Paripović, Dušan
AU  - Janać, Jelena
AU  - Joksić, Jelena
AU  - Gojković, Tamara
AU  - Spasojević-Kalimanovska, Vesna
AU  - Peco-Antić, Amira
AU  - Miloševski-Lomić, Gordana
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2727
AB  - Background: Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.Methods: A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.Results: Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese children. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p= 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles ( =-0.423; p= 0.025) in the group with hypertension.Conclusions: The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Scandinavian Journal of Clinical and Laboratory Investigation
T1  - Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents
VL  - 76
IS  - 6
SP  - 472
EP  - 478
DO  - 10.1080/00365513.2016.1201849
ER  - 

@article{
author = "Bekhet, Osama H. and Zeljković, Aleksandra and Vekić, Jelena and Paripović, Dušan and Janać, Jelena and Joksić, Jelena and Gojković, Tamara and Spasojević-Kalimanovska, Vesna and Peco-Antić, Amira and Miloševski-Lomić, Gordana and Jelić-Ivanović, Zorana",
year = "2016",
abstract = "Background: Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.Methods: A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.Results: Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese children. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p= 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles ( =-0.423; p= 0.025) in the group with hypertension.Conclusions: The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
title = "Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents",
volume = "76",
number = "6",
pages = "472-478",
doi = "10.1080/00365513.2016.1201849"
}

Bekhet, O. H., Zeljković, A., Vekić, J., Paripović, D., Janać, J., Joksić, J., Gojković, T., Spasojević-Kalimanovska, V., Peco-Antić, A., Miloševski-Lomić, G.,& Jelić-Ivanović, Z.. (2016). Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation
Taylor & Francis Ltd, Abingdon., 76(6), 472-478.
https://doi.org/10.1080/00365513.2016.1201849

Bekhet OH, Zeljković A, Vekić J, Paripović D, Janać J, Joksić J, Gojković T, Spasojević-Kalimanovska V, Peco-Antić A, Miloševski-Lomić G, Jelić-Ivanović Z. Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation. 2016;76(6):472-478.
doi:10.1080/00365513.2016.1201849 .

Bekhet, Osama H., Zeljković, Aleksandra, Vekić, Jelena, Paripović, Dušan, Janać, Jelena, Joksić, Jelena, Gojković, Tamara, Spasojević-Kalimanovska, Vesna, Peco-Antić, Amira, Miloševski-Lomić, Gordana, Jelić-Ivanović, Zorana, "Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents" in Scandinavian Journal of Clinical and Laboratory Investigation, 76, no. 6 (2016):472-478,
https://doi.org/10.1080/00365513.2016.1201849 . .

TY  - CONF
AU  - Dimitrijević-Srećković, Vesna
AU  - Srecković, B.
AU  - Janeski, H.
AU  - Soldatović, Ivan
AU  - Janać, Jelena
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2444
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Abdominal obesity responsible for depression and risk of early atherosclerosis in adolescents and youth
VL  - 241
IS  - 1
SP  - e167
EP  - e167
DO  - 10.1016/j.atherosclerosis.2015.04.859
ER  - 

@conference{
author = "Dimitrijević-Srećković, Vesna and Srecković, B. and Janeski, H. and Soldatović, Ivan and Janać, Jelena and Jelić-Ivanović, Zorana",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Abdominal obesity responsible for depression and risk of early atherosclerosis in adolescents and youth",
volume = "241",
number = "1",
pages = "e167-e167",
doi = "10.1016/j.atherosclerosis.2015.04.859"
}

Dimitrijević-Srećković, V., Srecković, B., Janeski, H., Soldatović, I., Janać, J.,& Jelić-Ivanović, Z.. (2015). Abdominal obesity responsible for depression and risk of early atherosclerosis in adolescents and youth. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 241(1), e167-e167.
https://doi.org/10.1016/j.atherosclerosis.2015.04.859

Dimitrijević-Srećković V, Srecković B, Janeski H, Soldatović I, Janać J, Jelić-Ivanović Z. Abdominal obesity responsible for depression and risk of early atherosclerosis in adolescents and youth. in Atherosclerosis. 2015;241(1):e167-e167.
doi:10.1016/j.atherosclerosis.2015.04.859 .

Dimitrijević-Srećković, Vesna, Srecković, B., Janeski, H., Soldatović, Ivan, Janać, Jelena, Jelić-Ivanović, Zorana, "Abdominal obesity responsible for depression and risk of early atherosclerosis in adolescents and youth" in Atherosclerosis, 241, no. 1 (2015):e167-e167,
https://doi.org/10.1016/j.atherosclerosis.2015.04.859 . .

TY  - CONF
AU  - Dimitrijević-Srećković, Vesna
AU  - Janeski, H.
AU  - Srecković, B.
AU  - Soldatović, Ivan
AU  - Janać, Jelena
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2447
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Progression of abdominal obesity in youth followed by testosterone decrease leading to erectile dysfunction and risk of early atherosclerosis
VL  - 241
IS  - 1
SP  - e167
EP  - e167
DO  - 10.1016/j.atherosclerosis.2015.04.860
ER  - 

@conference{
author = "Dimitrijević-Srećković, Vesna and Janeski, H. and Srecković, B. and Soldatović, Ivan and Janać, Jelena and Jelić-Ivanović, Zorana",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Progression of abdominal obesity in youth followed by testosterone decrease leading to erectile dysfunction and risk of early atherosclerosis",
volume = "241",
number = "1",
pages = "e167-e167",
doi = "10.1016/j.atherosclerosis.2015.04.860"
}

Dimitrijević-Srećković, V., Janeski, H., Srecković, B., Soldatović, I., Janać, J.,& Jelić-Ivanović, Z.. (2015). Progression of abdominal obesity in youth followed by testosterone decrease leading to erectile dysfunction and risk of early atherosclerosis. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 241(1), e167-e167.
https://doi.org/10.1016/j.atherosclerosis.2015.04.860

Dimitrijević-Srećković V, Janeski H, Srecković B, Soldatović I, Janać J, Jelić-Ivanović Z. Progression of abdominal obesity in youth followed by testosterone decrease leading to erectile dysfunction and risk of early atherosclerosis. in Atherosclerosis. 2015;241(1):e167-e167.
doi:10.1016/j.atherosclerosis.2015.04.860 .

Dimitrijević-Srećković, Vesna, Janeski, H., Srecković, B., Soldatović, Ivan, Janać, Jelena, Jelić-Ivanović, Zorana, "Progression of abdominal obesity in youth followed by testosterone decrease leading to erectile dysfunction and risk of early atherosclerosis" in Atherosclerosis, 241, no. 1 (2015):e167-e167,
https://doi.org/10.1016/j.atherosclerosis.2015.04.860 . .

TY  - JOUR
AU  - Kotur-Stevuljević, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Jelić-Ivanović, Zorana
AU  - Stefanović, Aleksandra
AU  - Gojković, Tamara
AU  - Joksić, Jelena
AU  - Sopić, Miron
AU  - Gulan, Brankica
AU  - Janać, Jelena
AU  - Milošević, Sanja
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2407
AB  - Objective: The connection of oxidative stress with dyslipidemia creates a newly-emerging atherosclerosis risk factor involved in acute ischemic stroke development. This study analyzed the influence of oxidative stress on structural changes of high-density lipoprotein (HDL) particles connected with modification in protective paraoxonase 1 (PON1) activity. Methods: This study used 185 patients with acute ischemic stroke and 185 apparently healthy controls. Oxidative stress status, PON1 status, lipids and high-sensitivity C-reactive protein (hsCRP) were determined. In isolated HDL lipoprotein fraction we determined selected markers of oxidative stress (malondialdehyde, MDA) and the content of total sulfhydryl (SH) groups. The capability of oxidative and PON1 status parameters to discriminate patients according to survival status was evaluated. Results: Stroke patients had lower HDL-cholesterol than controls and a remarkable fall in PON1 activity (control group-227 U/L, survivors-42 U/L, lethal outcome group-61 U/L, p  lt  0.001), along with more prominent inflammation. Pronounced oxidative stress and impaired antioxidative protection was present among patients. HDL fraction analysis revealed a significant decrease of SH groups content (control group vs. patients, p  lt  0.05) and increased in MDA content in patients (lethal outcome vs. control group, p  lt  0.05). According to logistic regression analysis, the best predictor of disease outcome was oxidative stress marker - prooxidative-antioxidative balance (PAB). Conclusions: Pronounced oxidative stress in this group of acute ischemic stroke patients probably led to HDL structural changes, which could further cause an alteration or decrease of PON1 activity. Evidence of increased prooxidant level associated with decreased protective, antioxidative factors suggests their mutual involvement in this complex pathology.
PB  - Elsevier Ireland Ltd, Clare
T2  - Atherosclerosis
T1  - Oxidative stress and paraoxonase 1 status in acute ischemic stroke patients
VL  - 241
IS  - 1
SP  - 192
EP  - 198
DO  - 10.1016/j.atherosclerosis.2015.05.016
ER  - 

@article{
author = "Kotur-Stevuljević, Jelena and Bogavac-Stanojević, Nataša and Jelić-Ivanović, Zorana and Stefanović, Aleksandra and Gojković, Tamara and Joksić, Jelena and Sopić, Miron and Gulan, Brankica and Janać, Jelena and Milošević, Sanja",
year = "2015",
abstract = "Objective: The connection of oxidative stress with dyslipidemia creates a newly-emerging atherosclerosis risk factor involved in acute ischemic stroke development. This study analyzed the influence of oxidative stress on structural changes of high-density lipoprotein (HDL) particles connected with modification in protective paraoxonase 1 (PON1) activity. Methods: This study used 185 patients with acute ischemic stroke and 185 apparently healthy controls. Oxidative stress status, PON1 status, lipids and high-sensitivity C-reactive protein (hsCRP) were determined. In isolated HDL lipoprotein fraction we determined selected markers of oxidative stress (malondialdehyde, MDA) and the content of total sulfhydryl (SH) groups. The capability of oxidative and PON1 status parameters to discriminate patients according to survival status was evaluated. Results: Stroke patients had lower HDL-cholesterol than controls and a remarkable fall in PON1 activity (control group-227 U/L, survivors-42 U/L, lethal outcome group-61 U/L, p  lt  0.001), along with more prominent inflammation. Pronounced oxidative stress and impaired antioxidative protection was present among patients. HDL fraction analysis revealed a significant decrease of SH groups content (control group vs. patients, p  lt  0.05) and increased in MDA content in patients (lethal outcome vs. control group, p  lt  0.05). According to logistic regression analysis, the best predictor of disease outcome was oxidative stress marker - prooxidative-antioxidative balance (PAB). Conclusions: Pronounced oxidative stress in this group of acute ischemic stroke patients probably led to HDL structural changes, which could further cause an alteration or decrease of PON1 activity. Evidence of increased prooxidant level associated with decreased protective, antioxidative factors suggests their mutual involvement in this complex pathology.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Oxidative stress and paraoxonase 1 status in acute ischemic stroke patients",
volume = "241",
number = "1",
pages = "192-198",
doi = "10.1016/j.atherosclerosis.2015.05.016"
}

Kotur-Stevuljević, J., Bogavac-Stanojević, N., Jelić-Ivanović, Z., Stefanović, A., Gojković, T., Joksić, J., Sopić, M., Gulan, B., Janać, J.,& Milošević, S.. (2015). Oxidative stress and paraoxonase 1 status in acute ischemic stroke patients. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 241(1), 192-198.
https://doi.org/10.1016/j.atherosclerosis.2015.05.016

Kotur-Stevuljević J, Bogavac-Stanojević N, Jelić-Ivanović Z, Stefanović A, Gojković T, Joksić J, Sopić M, Gulan B, Janać J, Milošević S. Oxidative stress and paraoxonase 1 status in acute ischemic stroke patients. in Atherosclerosis. 2015;241(1):192-198.
doi:10.1016/j.atherosclerosis.2015.05.016 .

Kotur-Stevuljević, Jelena, Bogavac-Stanojević, Nataša, Jelić-Ivanović, Zorana, Stefanović, Aleksandra, Gojković, Tamara, Joksić, Jelena, Sopić, Miron, Gulan, Brankica, Janać, Jelena, Milošević, Sanja, "Oxidative stress and paraoxonase 1 status in acute ischemic stroke patients" in Atherosclerosis, 241, no. 1 (2015):192-198,
https://doi.org/10.1016/j.atherosclerosis.2015.05.016 . .