TY  - CONF
AU  - Bonderović, Vera
AU  - Manić, Luka
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Stojilković, Nikola
AU  - Jorgovanović, Dragica
AU  - Grahovac, Lazar
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5510
AB  - Poslednjih decenija prošlog veka naučnici su utvrdili da pojedine hemikalije, mogu uticati na brojne sisteme organa i izazvati štetne efekte po naše zdravlje. Među hemikalijama sa kojima dolazimo u kontakt gotovo svakodnevno, posebno mesto zauzimaju hemikalije koje mogu delovati na endokrini sistem. ...
AB  - In the last decades of the twentieth century, scientists have observed that exposure to certain, human-made chemicals can affect numerous organ systems and cause harmful effects on our health. Among the chemicals hiding in everyday products, substances of special concern are those that can affect the endocrine system. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama
T1  - Informed mom, healthy baby - How to live safely with chemicals
SP  - 117
EP  - 118
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5510
ER  - 

@conference{
author = "Bonderović, Vera and Manić, Luka and Živančević, Katarina and Baralić, Katarina and Vukelić, Dragana and Marić, Đurđica and Stojilković, Nikola and Jorgovanović, Dragica and Grahovac, Lazar and Anđelković, Milena and Repić, Aleksandra and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Poslednjih decenija prošlog veka naučnici su utvrdili da pojedine hemikalije, mogu uticati na brojne sisteme organa i izazvati štetne efekte po naše zdravlje. Među hemikalijama sa kojima dolazimo u kontakt gotovo svakodnevno, posebno mesto zauzimaju hemikalije koje mogu delovati na endokrini sistem. ..., In the last decades of the twentieth century, scientists have observed that exposure to certain, human-made chemicals can affect numerous organ systems and cause harmful effects on our health. Among the chemicals hiding in everyday products, substances of special concern are those that can affect the endocrine system. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama, Informed mom, healthy baby - How to live safely with chemicals",
pages = "117-118",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5510"
}

Bonderović, V., Manić, L., Živančević, K., Baralić, K., Vukelić, D., Marić, Đ., Stojilković, N., Jorgovanović, D., Grahovac, L., Anđelković, M., Repić, A., Ćurčić, M., Đukić-Ćosić, D., Bulat, Z., Antonijević, B.,& Buha-Đorđević, A.. (2023). Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 117-118.
https://hdl.handle.net/21.15107/rcub_farfar_5510

Bonderović V, Manić L, Živančević K, Baralić K, Vukelić D, Marić Đ, Stojilković N, Jorgovanović D, Grahovac L, Anđelković M, Repić A, Ćurčić M, Đukić-Ćosić D, Bulat Z, Antonijević B, Buha-Đorđević A. Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:117-118.
https://hdl.handle.net/21.15107/rcub_farfar_5510 .

Bonderović, Vera, Manić, Luka, Živančević, Katarina, Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Stojilković, Nikola, Jorgovanović, Dragica, Grahovac, Lazar, Anđelković, Milena, Repić, Aleksandra, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):117-118,
https://hdl.handle.net/21.15107/rcub_farfar_5510 .

TY  - CONF
AU  - Radović, Biljana
AU  - Stojilković, Nikola
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Vukelić, Dragana
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5485
AB  - Aktivnosti prilikom rastavljanje e-otpada predstavljaju značajan izvor mnogih štetnih komponenti, što dovodi do svakodnevnog izlaganja radnika toksičnim isparenjima koja se sastoje od različitih metala i organskih jedinjenja. Svaka od ovih hemikalija iz životne sredine ponaosob ispoljava toksične efekte ometajući homeostazu hormona, a njihov potencijal da deluju kao endokrini ometači je već potvrđen. ...
AB  - E-waste dismantling activities constitute a significant source of many harmful components, resulting in everyday exposure of workers to toxic fumes consisting of different metals and organic compounds. Each of these environmental chemicals individually exerts toxic effects by interfering with hormone homeostasis and their potential to act as endocrine disruptors (EDs) has already been confirmed. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book, 2023, 57-58
T1  - Prašina od rastavljanja e-otpada kao izvor hemikalija koje ometaju rad endokrinog sistema: In silico testiranje toksičnosti smeše na štitnu žlezdu i muški reproduktivni sistem
T1  - Dust from e - waste dismantling as a source of endocrine disrupting chemicals: In silico testing of mixture toxicity on thyroid gland and male reproductive system
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5485
ER  - 

@conference{
author = "Radović, Biljana and Stojilković, Nikola and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Vukelić, Dragana and Baralić, Katarina and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "Aktivnosti prilikom rastavljanje e-otpada predstavljaju značajan izvor mnogih štetnih komponenti, što dovodi do svakodnevnog izlaganja radnika toksičnim isparenjima koja se sastoje od različitih metala i organskih jedinjenja. Svaka od ovih hemikalija iz životne sredine ponaosob ispoljava toksične efekte ometajući homeostazu hormona, a njihov potencijal da deluju kao endokrini ometači je već potvrđen. ..., E-waste dismantling activities constitute a significant source of many harmful components, resulting in everyday exposure of workers to toxic fumes consisting of different metals and organic compounds. Each of these environmental chemicals individually exerts toxic effects by interfering with hormone homeostasis and their potential to act as endocrine disruptors (EDs) has already been confirmed. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book, 2023, 57-58",
title = "Prašina od rastavljanja e-otpada kao izvor hemikalija koje ometaju rad endokrinog sistema: In silico testiranje toksičnosti smeše na štitnu žlezdu i muški reproduktivni sistem, Dust from e - waste dismantling as a source of endocrine disrupting chemicals: In silico testing of mixture toxicity on thyroid gland and male reproductive system",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5485"
}

Radović, B., Stojilković, N., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Vukelić, D., Baralić, K., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2023). Prašina od rastavljanja e-otpada kao izvor hemikalija koje ometaju rad endokrinog sistema: In silico testiranje toksičnosti smeše na štitnu žlezdu i muški reproduktivni sistem. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book, 2023, 57-58
Udruženje toksikologa Srbije..
https://hdl.handle.net/21.15107/rcub_farfar_5485

Radović B, Stojilković N, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Vukelić D, Baralić K, Đukić-Ćosić D, Bulat Z, Antonijević B. Prašina od rastavljanja e-otpada kao izvor hemikalija koje ometaju rad endokrinog sistema: In silico testiranje toksičnosti smeše na štitnu žlezdu i muški reproduktivni sistem. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book, 2023, 57-58. 2023;.
https://hdl.handle.net/21.15107/rcub_farfar_5485 .

Radović, Biljana, Stojilković, Nikola, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Vukelić, Dragana, Baralić, Katarina, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "Prašina od rastavljanja e-otpada kao izvor hemikalija koje ometaju rad endokrinog sistema: In silico testiranje toksičnosti smeše na štitnu žlezdu i muški reproduktivni sistem" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book, 2023, 57-58 (2023),
https://hdl.handle.net/21.15107/rcub_farfar_5485 .

TY  - CONF
AU  - Stojilković, Nikola
AU  - Stojković, Miodrag
AU  - Ćurčić, Marijana
AU  - Vukelić, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Stojanović, Aleksandra
AU  - Zdravković, Aleksandra
AU  - Stojadinović, Tina
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5428
AB  - Jedan od najvećih izazova u toksikologiji je procena toksičnosti hemijskim smešama, odnosno procena
rizika po zdravlje ljudi usled celoživotnog izlaganja složenim smešama različitih supstanci. Studije bio-
monitoringa su nesumnjivo pokazale prisustvo preko stotinu hemikalija u ljudskom telu. ...
AB  - One of the biggest challenges in toxicology is the evaluation of the toxicity of chemical mixtures, as
well as the risk to human health due to lifelong exposure to complex mixtures of different substances.
Biomonitoring studies have undoubtedly shown the presence of over a hundred chemicals in the
human body. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova
T1  - Effect of lead and polychlorinated-biphenyls mixture on sperm cells and serum level of testosterone in rats
SP  - 65
EP  - 66
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5428
ER  - 

@conference{
author = "Stojilković, Nikola and Stojković, Miodrag and Ćurčić, Marijana and Vukelić, Dragana and Buha-Đorđević, Aleksandra and Stojanović, Aleksandra and Zdravković, Aleksandra and Stojadinović, Tina and Marić, Đurđica and Baralić, Katarina and Antonijević, Biljana",
year = "2023",
abstract = "Jedan od najvećih izazova u toksikologiji je procena toksičnosti hemijskim smešama, odnosno procena
rizika po zdravlje ljudi usled celoživotnog izlaganja složenim smešama različitih supstanci. Studije bio-
monitoringa su nesumnjivo pokazale prisustvo preko stotinu hemikalija u ljudskom telu. ..., One of the biggest challenges in toxicology is the evaluation of the toxicity of chemical mixtures, as
well as the risk to human health due to lifelong exposure to complex mixtures of different substances.
Biomonitoring studies have undoubtedly shown the presence of over a hundred chemicals in the
human body. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova, Effect of lead and polychlorinated-biphenyls mixture on sperm cells and serum level of testosterone in rats",
pages = "65-66",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5428"
}

Stojilković, N., Stojković, M., Ćurčić, M., Vukelić, D., Buha-Đorđević, A., Stojanović, A., Zdravković, A., Stojadinović, T., Marić, Đ., Baralić, K.,& Antonijević, B.. (2023). Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 65-66.
https://hdl.handle.net/21.15107/rcub_farfar_5428

Stojilković N, Stojković M, Ćurčić M, Vukelić D, Buha-Đorđević A, Stojanović A, Zdravković A, Stojadinović T, Marić Đ, Baralić K, Antonijević B. Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:65-66.
https://hdl.handle.net/21.15107/rcub_farfar_5428 .

Stojilković, Nikola, Stojković, Miodrag, Ćurčić, Marijana, Vukelić, Dragana, Buha-Đorđević, Aleksandra, Stojanović, Aleksandra, Zdravković, Aleksandra, Stojadinović, Tina, Marić, Đurđica, Baralić, Katarina, Antonijević, Biljana, "Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):65-66,
https://hdl.handle.net/21.15107/rcub_farfar_5428 .

TY  - CONF
AU  - Radović, Biljana
AU  - Stojilković, Nikola
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Vukelić, Dragana
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5429
AB  - Sobzirom na to da su ljudi u svakodnevnom životu konstantno izloženi smešama hemikalija koje deluju
putem zajedničkih mehanizama, važno je proceniti da li su ovi „koktel efekti“ izraženiji u poređenju sa
dejstvom pojedinačnih hemikalija. ...
AB  - Due to the fact that in daily life humans are constantly exposed to mixtures of chemicals acting by
a common mechanism of action, it is important to assess whether these "cocktail effects" are more
pronounced compared to the effects of single chemicals. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Procena toksičnih efekata smeše olova i polihlorovanih bifenila na redoks status u bubrezima pacova
T1  - Assessment of lead and polychlorinated biphenyls mixture toxic effects on redox status in rat kidneys
SP  - 67
EP  - 68
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5429
ER  - 

@conference{
author = "Radović, Biljana and Stojilković, Nikola and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Vukelić, Dragana and Baralić, Katarina and Marić, Đurđica and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "Sobzirom na to da su ljudi u svakodnevnom životu konstantno izloženi smešama hemikalija koje deluju
putem zajedničkih mehanizama, važno je proceniti da li su ovi „koktel efekti“ izraženiji u poređenju sa
dejstvom pojedinačnih hemikalija. ..., Due to the fact that in daily life humans are constantly exposed to mixtures of chemicals acting by
a common mechanism of action, it is important to assess whether these "cocktail effects" are more
pronounced compared to the effects of single chemicals. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Procena toksičnih efekata smeše olova i polihlorovanih bifenila na redoks status u bubrezima pacova, Assessment of lead and polychlorinated biphenyls mixture toxic effects on redox status in rat kidneys",
pages = "67-68",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5429"
}

Radović, B., Stojilković, N., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Vukelić, D., Baralić, K., Marić, Đ., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2023). Procena toksičnih efekata smeše olova i polihlorovanih bifenila na redoks status u bubrezima pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 67-68.
https://hdl.handle.net/21.15107/rcub_farfar_5429

Radović B, Stojilković N, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Vukelić D, Baralić K, Marić Đ, Đukić-Ćosić D, Bulat Z, Antonijević B. Procena toksičnih efekata smeše olova i polihlorovanih bifenila na redoks status u bubrezima pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:67-68.
https://hdl.handle.net/21.15107/rcub_farfar_5429 .

Radović, Biljana, Stojilković, Nikola, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Vukelić, Dragana, Baralić, Katarina, Marić, Đurđica, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "Procena toksičnih efekata smeše olova i polihlorovanih bifenila na redoks status u bubrezima pacova" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):67-68,
https://hdl.handle.net/21.15107/rcub_farfar_5429 .

TY  - CONF
AU  - Radović, Biljana
AU  - Stojilković, Nikola
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Đukić-Ćosić, Danijela
AU  - Marić, Đurđica
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5175
AB  - Considering that combined exposure to toxic metals and organic pollutants may induce various adverse effects on human health, it is important to elucidate the mechanisms of toxicity that occur after lowdose exposure to these chemicals in a real-life scenario. ...
PB  - Elsevier
C3  - Toxicology Letters
T1  - Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats
VL  - 384
IS  - S1
SP  - S223
EP  - S223
DO  - 10.1016/S0378-4274(23)00790-7
ER  - 

@conference{
author = "Radović, Biljana and Stojilković, Nikola and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Baralić, Katarina and Vukelić, Dragana and Đukić-Ćosić, Danijela and Marić, Đurđica and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "Considering that combined exposure to toxic metals and organic pollutants may induce various adverse effects on human health, it is important to elucidate the mechanisms of toxicity that occur after lowdose exposure to these chemicals in a real-life scenario. ...",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats",
volume = "384",
number = "S1",
pages = "S223-S223",
doi = "10.1016/S0378-4274(23)00790-7"
}

Radović, B., Stojilković, N., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Baralić, K., Vukelić, D., Đukić-Ćosić, D., Marić, Đ., Bulat, Z.,& Antonijević, B.. (2023). Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats. in Toxicology Letters
Elsevier., 384(S1), S223-S223.
https://doi.org/10.1016/S0378-4274(23)00790-7

Radović B, Stojilković N, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Baralić K, Vukelić D, Đukić-Ćosić D, Marić Đ, Bulat Z, Antonijević B. Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats. in Toxicology Letters. 2023;384(S1):S223-S223.
doi:10.1016/S0378-4274(23)00790-7 .

Radović, Biljana, Stojilković, Nikola, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Baralić, Katarina, Vukelić, Dragana, Đukić-Ćosić, Danijela, Marić, Đurđica, Bulat, Zorica, Antonijević, Biljana, "Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats" in Toxicology Letters, 384, no. S1 (2023):S223-S223,
https://doi.org/10.1016/S0378-4274(23)00790-7 . .

TY  - JOUR
AU  - Stojilković, Nikola
AU  - Radović, Biljana
AU  - Vukelić, Dragana
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5142
AB  - Toxicological research is mostly limited to considering the effects of a single substance, even though the real exposure of people is reflected in their daily exposure to many different chemical substances in low-doses. This in silico toxicogenomic study aims to provide evidence for the selected environmental (organo)metals (lead, cadmium, methyl mercury) + polychlorinated biphenyls mixture involvement in the possible alteration of thyroid, and male reproductive system function, and furthermore to predict the possible toxic mechanisms of the environmental cocktail. The Comparative Toxicogenomic Database, GeneMANIA online software, and ToppGene Suite portal were used as the main tools for toxicogenomic data mining and gene ontology analysis. The results show that 35 annotated common genes between selected chemicals and endocrine system diseases can interact on the co-expression level. Our study highlighted the disruption of the cytokines, the cell's response to oxidative stress, and the influence of the transcription factors as the potential core of toxicological mechanisms of the discussed mixture's effects. The connected toxicological effects of the tested mixture were abnormal sperm cells, a disrupted level of testosterone, and thyroid hormones. The core mechanisms of these effects were inflammation, oxidative stress, disruption of androgen receptor signaling, and the alteration of the FOXO3-Keap-1/NRF2-HMOX1-NQO1 pathway signaling most likely controlled by the co-expression of overlapped genes among used chemicals. This in silico research can be used as a potential core for the determination of biomarkers that can be monitored in future further in vitro and in vivo experiments.
PB  - Elsevier
T2  - Environmental Research
T1  - Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining
DO  - 10.1016/j.envres.2023.117274
ER  - 

@article{
author = "Stojilković, Nikola and Radović, Biljana and Vukelić, Dragana and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Baralić, Katarina and Marić, Đurđica and Bulat, Zorica and Đukić-Ćosić, Danijela and Antonijević, Biljana",
year = "2023",
abstract = "Toxicological research is mostly limited to considering the effects of a single substance, even though the real exposure of people is reflected in their daily exposure to many different chemical substances in low-doses. This in silico toxicogenomic study aims to provide evidence for the selected environmental (organo)metals (lead, cadmium, methyl mercury) + polychlorinated biphenyls mixture involvement in the possible alteration of thyroid, and male reproductive system function, and furthermore to predict the possible toxic mechanisms of the environmental cocktail. The Comparative Toxicogenomic Database, GeneMANIA online software, and ToppGene Suite portal were used as the main tools for toxicogenomic data mining and gene ontology analysis. The results show that 35 annotated common genes between selected chemicals and endocrine system diseases can interact on the co-expression level. Our study highlighted the disruption of the cytokines, the cell's response to oxidative stress, and the influence of the transcription factors as the potential core of toxicological mechanisms of the discussed mixture's effects. The connected toxicological effects of the tested mixture were abnormal sperm cells, a disrupted level of testosterone, and thyroid hormones. The core mechanisms of these effects were inflammation, oxidative stress, disruption of androgen receptor signaling, and the alteration of the FOXO3-Keap-1/NRF2-HMOX1-NQO1 pathway signaling most likely controlled by the co-expression of overlapped genes among used chemicals. This in silico research can be used as a potential core for the determination of biomarkers that can be monitored in future further in vitro and in vivo experiments.",
publisher = "Elsevier",
journal = "Environmental Research",
title = "Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining",
doi = "10.1016/j.envres.2023.117274"
}

Stojilković, N., Radović, B., Vukelić, D., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Baralić, K., Marić, Đ., Bulat, Z., Đukić-Ćosić, D.,& Antonijević, B.. (2023). Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining. in Environmental Research
Elsevier..
https://doi.org/10.1016/j.envres.2023.117274

Stojilković N, Radović B, Vukelić D, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Baralić K, Marić Đ, Bulat Z, Đukić-Ćosić D, Antonijević B. Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining. in Environmental Research. 2023;.
doi:10.1016/j.envres.2023.117274 .

Stojilković, Nikola, Radović, Biljana, Vukelić, Dragana, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Baralić, Katarina, Marić, Đurđica, Bulat, Zorica, Đukić-Ćosić, Danijela, Antonijević, Biljana, "Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining" in Environmental Research (2023),
https://doi.org/10.1016/j.envres.2023.117274 . .

TY  - JOUR
AU  - Radović, Biljana
AU  - Stojilković, Nikola
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Vukelić-Javorac, Dragana
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4613
AB  - The current study aimed to assess the connection between the mixture of lead (Pb), cadmium (Cd), arsenic (As), methylmercury (MeHg) and decabrominated diphenyl ether (decaBDE) and thyroid function, by using in silico toxicogenomic data-mining approach. To obtain the linkage between investigated toxic mixture and thyroid diseases (TDs), the Comparative Toxicogenomics Database (CTD) was used, while gene ontology (GO) enrichment analysis was performed by ToppGeneSuite portal. The analysis has shown 10 genes connected to all chemicals present in the mixture and TDs (CAT, GSR, IFNG, IL1B, IL4, IL6, MAPK1, SOD2, TGFB1, TNF), most of which were in co-expression (45.68%), or belonged to the same pathway (30.47%). Top 5 biological processes and molecular functions affected by the investigated mixture emphasized the role of two common mechanisms – oxidative stress and inflammation. Cytokines and inflammatory response was listed as the main molecular pathway that may be triggered by simultaneous exposure to toxic metal(oid)s and decaBDE and connected to TDs. The direct relations between Pb/decaBDE and redox status impairment in thyroid tissue was confirmed by our chemical-phenotype interaction analysis, while the strongest linkage between Pb, As and decaBDE and thyroid disorders was found. The obtained results provide better understanding of molecular mechanisms involved in the thyrotoxicity of the investigated mixture, and can be used to direct further research.
PB  - Elsevier Ireland Ltd
T2  - Toxicology
T1  - In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether
VL  - 489
DO  - 10.1016/j.tox.2023.153496
ER  - 

@article{
author = "Radović, Biljana and Stojilković, Nikola and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Vukelić-Javorac, Dragana and Baralić, Katarina and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "The current study aimed to assess the connection between the mixture of lead (Pb), cadmium (Cd), arsenic (As), methylmercury (MeHg) and decabrominated diphenyl ether (decaBDE) and thyroid function, by using in silico toxicogenomic data-mining approach. To obtain the linkage between investigated toxic mixture and thyroid diseases (TDs), the Comparative Toxicogenomics Database (CTD) was used, while gene ontology (GO) enrichment analysis was performed by ToppGeneSuite portal. The analysis has shown 10 genes connected to all chemicals present in the mixture and TDs (CAT, GSR, IFNG, IL1B, IL4, IL6, MAPK1, SOD2, TGFB1, TNF), most of which were in co-expression (45.68%), or belonged to the same pathway (30.47%). Top 5 biological processes and molecular functions affected by the investigated mixture emphasized the role of two common mechanisms – oxidative stress and inflammation. Cytokines and inflammatory response was listed as the main molecular pathway that may be triggered by simultaneous exposure to toxic metal(oid)s and decaBDE and connected to TDs. The direct relations between Pb/decaBDE and redox status impairment in thyroid tissue was confirmed by our chemical-phenotype interaction analysis, while the strongest linkage between Pb, As and decaBDE and thyroid disorders was found. The obtained results provide better understanding of molecular mechanisms involved in the thyrotoxicity of the investigated mixture, and can be used to direct further research.",
publisher = "Elsevier Ireland Ltd",
journal = "Toxicology",
title = "In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether",
volume = "489",
doi = "10.1016/j.tox.2023.153496"
}

Radović, B., Stojilković, N., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Vukelić-Javorac, D., Baralić, K., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2023). In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether. in Toxicology
Elsevier Ireland Ltd., 489.
https://doi.org/10.1016/j.tox.2023.153496

Radović B, Stojilković N, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Vukelić-Javorac D, Baralić K, Đukić-Ćosić D, Bulat Z, Antonijević B. In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether. in Toxicology. 2023;489.
doi:10.1016/j.tox.2023.153496 .

Radović, Biljana, Stojilković, Nikola, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Vukelić-Javorac, Dragana, Baralić, Katarina, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether" in Toxicology, 489 (2023),
https://doi.org/10.1016/j.tox.2023.153496 . .

TY  - CONF
AU  - Stojilković, Nikola
AU  - Stojković, Miodrag
AU  - Ćurčić, Marijana
AU  - Javorac, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Stojanović, Aleksandra
AU  - Zdravković, Aleksandra
AU  - Stojadinović, Tina
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Antonijević, Biljana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4631
AB  - Benchmark dose (BMD) approach extends the use of data and allows a quantification
of the uncertainties and confirmation of the effect. The objective of this study was to
investigate whether a mixture of lead (Pb) and polychlorinated-biphenyls (PCBs)
has any effect on sperm cells, and whether these effects are dose dependent. The
experiment was conducted in accordance with the approval of Ethical Committee No. 323-
07-11822/2018-05. Male Wistar rats were exposed to the mixture of Pb and PCBs by oral
gavage for 28 days. Doses od Pb in mixture were 0.1 mg/kg/day, 0.5 mg/kg/day and 1
mg/kg/day, while doses of PCBs in mixture were 0.25 mg/kg/day, 0.5 mg/kg/day, and 1
mg/kg/day respectively. Rats were anesthetized by the combination of ketamine/xylazine.
Through the scrotum section, the right testis and epididymis were collected, while sperm
cells were taken from the cauda of epididymis by diffusion in saline solution at 37°C. Sperm
motililty was determined by the light microscope. The aliquot of the sperm cells was fixated
with the combination of formalin in the phosphate buffer and used for morphology and
concentration sperm analysis. The benchmark dose lower confidence limit (BMDL40) of
0.00013 mg/kg/day was derived for the sperm motility effect of Pb and PCBs as co-variant.
From our results, we can conclude that the mortality was the most sensitive parameter. This
value is also one of the lowest BMDL for Pb, which can lead to conclusion that PCBs increase
the potency of Pb toxicity.
AB  - Pristup računanja Benchmark doze (BMD) proširuje upotrebu podataka, omogućava
kvantifikaciju nesigurnosti i potvrđuje efekat. Cilj ove studije bio je da se ispita da li smeša
olova (Pb) i polihlorovanih-bifenila (PCBs) ispoljava efekat na ćelije sperme, kao i da se ispita
da li su efekti dozno zavisni. Eksperiment je sproveden u skladu sa odobrenjem Etičkog
komiteta br. 323-07-11822 / 2018-05. Mužjaci Wistar pacova su bili izloženi smeši Pb i PCBs
oralnom gavažom tokom 28 dana. Doze Pb u smeši bile su 0,1 mg/kg/dan, 0,5 mg/kg/dan i 1
mg/kg/dan, dok su doze PCBs u smeši bile 0,25 mg/kg/dan, 0,5 mg/kg/dan i 1 mg/kg/dan.
Pacovi su anestezirani kombinacijom ketamin/ksilazin. Kroz presek skrotuma, sakupljeni su
desni testis i epididimis, spermatozoidi su prikupljeni u fiziološkom rastvoru na 37°C
difuzijom iz repnog dela epididimisa. Pokretljivost spermatozoida je određena svetlosnim
mikroskopom. Deo rastvora spermatozoida je fiksiran kombinacijom formalina u fosfatnom
puferu i korišćen za analizu morfologije i koncentracije spermatozoida. Donja granica
pouzdanosti benčmark doze (BMDL40) od 0,00013 mg/kg/dan je izračunata za pokretljivost
spermatozoida za Pb i PCBs-ima kao kovarijantu. Iz naših rezultata možemo zaključiti da je
najosetljiviji parametar pokretljivost spermatozoida. Ova vrednost je takođe jedna od
najnižih BMDL za Pb, što može dovesti do zaključka da PCBs povećavaju toksičnosti olova
kada su u smeši.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Effect of Lead and Polychlorinated-biphenyls Mixture on Sperm Cells in Rats
T1  - Efekti olova i polihlorovanih ‐ bifenila na ćelije sperme kod pacova
VL  - 72
IS  - 4 suplement
SP  - S583
EP  - S584
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4631
ER  - 

@conference{
author = "Stojilković, Nikola and Stojković, Miodrag and Ćurčić, Marijana and Javorac, Dragana and Buha-Đorđević, Aleksandra and Stojanović, Aleksandra and Zdravković, Aleksandra and Stojadinović, Tina and Marić, Đurđica and Baralić, Katarina and Antonijević, Biljana",
year = "2022",
abstract = "Benchmark dose (BMD) approach extends the use of data and allows a quantification
of the uncertainties and confirmation of the effect. The objective of this study was to
investigate whether a mixture of lead (Pb) and polychlorinated-biphenyls (PCBs)
has any effect on sperm cells, and whether these effects are dose dependent. The
experiment was conducted in accordance with the approval of Ethical Committee No. 323-
07-11822/2018-05. Male Wistar rats were exposed to the mixture of Pb and PCBs by oral
gavage for 28 days. Doses od Pb in mixture were 0.1 mg/kg/day, 0.5 mg/kg/day and 1
mg/kg/day, while doses of PCBs in mixture were 0.25 mg/kg/day, 0.5 mg/kg/day, and 1
mg/kg/day respectively. Rats were anesthetized by the combination of ketamine/xylazine.
Through the scrotum section, the right testis and epididymis were collected, while sperm
cells were taken from the cauda of epididymis by diffusion in saline solution at 37°C. Sperm
motililty was determined by the light microscope. The aliquot of the sperm cells was fixated
with the combination of formalin in the phosphate buffer and used for morphology and
concentration sperm analysis. The benchmark dose lower confidence limit (BMDL40) of
0.00013 mg/kg/day was derived for the sperm motility effect of Pb and PCBs as co-variant.
From our results, we can conclude that the mortality was the most sensitive parameter. This
value is also one of the lowest BMDL for Pb, which can lead to conclusion that PCBs increase
the potency of Pb toxicity., Pristup računanja Benchmark doze (BMD) proširuje upotrebu podataka, omogućava
kvantifikaciju nesigurnosti i potvrđuje efekat. Cilj ove studije bio je da se ispita da li smeša
olova (Pb) i polihlorovanih-bifenila (PCBs) ispoljava efekat na ćelije sperme, kao i da se ispita
da li su efekti dozno zavisni. Eksperiment je sproveden u skladu sa odobrenjem Etičkog
komiteta br. 323-07-11822 / 2018-05. Mužjaci Wistar pacova su bili izloženi smeši Pb i PCBs
oralnom gavažom tokom 28 dana. Doze Pb u smeši bile su 0,1 mg/kg/dan, 0,5 mg/kg/dan i 1
mg/kg/dan, dok su doze PCBs u smeši bile 0,25 mg/kg/dan, 0,5 mg/kg/dan i 1 mg/kg/dan.
Pacovi su anestezirani kombinacijom ketamin/ksilazin. Kroz presek skrotuma, sakupljeni su
desni testis i epididimis, spermatozoidi su prikupljeni u fiziološkom rastvoru na 37°C
difuzijom iz repnog dela epididimisa. Pokretljivost spermatozoida je određena svetlosnim
mikroskopom. Deo rastvora spermatozoida je fiksiran kombinacijom formalina u fosfatnom
puferu i korišćen za analizu morfologije i koncentracije spermatozoida. Donja granica
pouzdanosti benčmark doze (BMDL40) od 0,00013 mg/kg/dan je izračunata za pokretljivost
spermatozoida za Pb i PCBs-ima kao kovarijantu. Iz naših rezultata možemo zaključiti da je
najosetljiviji parametar pokretljivost spermatozoida. Ova vrednost je takođe jedna od
najnižih BMDL za Pb, što može dovesti do zaključka da PCBs povećavaju toksičnosti olova
kada su u smeši.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Effect of Lead and Polychlorinated-biphenyls Mixture on Sperm Cells in Rats, Efekti olova i polihlorovanih ‐ bifenila na ćelije sperme kod pacova",
volume = "72",
number = "4 suplement",
pages = "S583-S584",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4631"
}

Stojilković, N., Stojković, M., Ćurčić, M., Javorac, D., Buha-Đorđević, A., Stojanović, A., Zdravković, A., Stojadinović, T., Marić, Đ., Baralić, K.,& Antonijević, B.. (2022). Effect of Lead and Polychlorinated-biphenyls Mixture on Sperm Cells in Rats. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S583-S584.
https://hdl.handle.net/21.15107/rcub_farfar_4631

Stojilković N, Stojković M, Ćurčić M, Javorac D, Buha-Đorđević A, Stojanović A, Zdravković A, Stojadinović T, Marić Đ, Baralić K, Antonijević B. Effect of Lead and Polychlorinated-biphenyls Mixture on Sperm Cells in Rats. in Arhiv za farmaciju. 2022;72(4 suplement):S583-S584.
https://hdl.handle.net/21.15107/rcub_farfar_4631 .

Stojilković, Nikola, Stojković, Miodrag, Ćurčić, Marijana, Javorac, Dragana, Buha-Đorđević, Aleksandra, Stojanović, Aleksandra, Zdravković, Aleksandra, Stojadinović, Tina, Marić, Đurđica, Baralić, Katarina, Antonijević, Biljana, "Effect of Lead and Polychlorinated-biphenyls Mixture on Sperm Cells in Rats" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S583-S584,
https://hdl.handle.net/21.15107/rcub_farfar_4631 .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Ćatović, Rialda
AU  - Ćirović, Tatjana
AU  - Stojilković, Nikola
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4627
AB  - The aim of this study was to evaluate the awareness of livestock breeders on the used
veterinary drugs in order to assess potential environmental contamination in the region of
Sjenica. Veterinary drugs can enter the environment mostly due to widespread usage, but
also as metabolites eliminated from the organisms. In order to evaluate the awareness of
livestock breeders, a survey questionnaire was used. Questions were related to the most
frequently used veterinary drugs without the supervision of a veterinary medical doctor. The
obtained data show that the awareness of domestic animal breeders on the use of veterinary
drugs is very low in the region of Sjenica. The most commonly used veterinary medicines
were antibiotics, streptomycin, and benzylpenicillin-procaine, antihelmintic, albendazole.
Unexpectedly, the animal breeders identified formaldehyde as veterinary medicine and used
it as a disinfectant in poultry raising. The results also show that breeders frequently treat
animals with drugs on their own, without control by veterinary medical doctors. Because of
the wide use of veterinary medicines in the region of Sjenica, it monitoring of the
environmental concentration of streptomycin, benzylpenicillin-procaine, and albendazole, as
well as metabolites in soil and water should be recommended. Moreover, human exposure to
these veterinary medicines could occur because of the abuse of veterinary medicines, no
consultations with veterinary medical doctors, and non-proper handling of waste from
animals.
AB  - Veterinarski lekovi dospevaju u životnu sredinu najčešće usled neadekvatnog
odlaganja otpada, ali i kao metaboliti iz organizma životinja. Cilj studije je bio procena nivoa
svesti uzgajivača stoke o upotrebi veterinarskih lekova u regionu Sjenice sa ciljem procene
potencijalne kontaminacije životne sredine. Za procenu nivoa svesti uzgajivača stoke
korišćen je anketni upitnik. Pitanja iz upitnika su se odnosila na najčešće korišćene
veterinarske lekove i korišćenje bez nadzora veterinara. Dobijeni podaci pokazuju da je nivo
svestu uzgajivača stoke u regionu Sjenice nizak jer koriste veterinarske lekove bez nadzora
veterinara. Najčešće koriste antibiotike, streptomicin i benzoil-penicilin, antihelmintik –
abendazol i, iznenađujuće, koriste formaldehid za dezinfekciju prostorija za smeštaj
životinja, pri čemu ga smatraju veterinarskim lekom. Zbog rasprostranjene upoutrebe
veterinarskih lekova u regionu Sjenice od strane uzgajivača stoke, a bez kontrole veterinara
preporučuje se monitoring streptomicina, benzoilpenicilina i abendazola kao i njihovih
metabolita u životnoj sredini, zemljištu i vodi. Potrebno je preduzeti dodatne mere opreza da
zbog niskog nivoa svesti ne bi došlo do izloženosti ljudi ovim veterinarskim lekovima i
njihovim metabolitima naročito zbog neadekvatnog tretiranja stajnjaka i drugog otpada.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Awareness on the use of veterinary drugs in the region of Sjenica as potential environmental pollutants
T1  - Svest o korišćenju veterinarskih lekova u regionu Sjenice kao potencijalnih zagađivača životne sredine
VL  - 72
IS  - 4 suplement
SP  - S577
EP  - S578
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4627
ER  - 

@conference{
author = "Ćurčić, Marijana and Ćatović, Rialda and Ćirović, Tatjana and Stojilković, Nikola and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Javorac, Dragana and Baralić, Katarina and Bulat, Zorica and Antonijević, Biljana",
year = "2022",
abstract = "The aim of this study was to evaluate the awareness of livestock breeders on the used
veterinary drugs in order to assess potential environmental contamination in the region of
Sjenica. Veterinary drugs can enter the environment mostly due to widespread usage, but
also as metabolites eliminated from the organisms. In order to evaluate the awareness of
livestock breeders, a survey questionnaire was used. Questions were related to the most
frequently used veterinary drugs without the supervision of a veterinary medical doctor. The
obtained data show that the awareness of domestic animal breeders on the use of veterinary
drugs is very low in the region of Sjenica. The most commonly used veterinary medicines
were antibiotics, streptomycin, and benzylpenicillin-procaine, antihelmintic, albendazole.
Unexpectedly, the animal breeders identified formaldehyde as veterinary medicine and used
it as a disinfectant in poultry raising. The results also show that breeders frequently treat
animals with drugs on their own, without control by veterinary medical doctors. Because of
the wide use of veterinary medicines in the region of Sjenica, it monitoring of the
environmental concentration of streptomycin, benzylpenicillin-procaine, and albendazole, as
well as metabolites in soil and water should be recommended. Moreover, human exposure to
these veterinary medicines could occur because of the abuse of veterinary medicines, no
consultations with veterinary medical doctors, and non-proper handling of waste from
animals., Veterinarski lekovi dospevaju u životnu sredinu najčešće usled neadekvatnog
odlaganja otpada, ali i kao metaboliti iz organizma životinja. Cilj studije je bio procena nivoa
svesti uzgajivača stoke o upotrebi veterinarskih lekova u regionu Sjenice sa ciljem procene
potencijalne kontaminacije životne sredine. Za procenu nivoa svesti uzgajivača stoke
korišćen je anketni upitnik. Pitanja iz upitnika su se odnosila na najčešće korišćene
veterinarske lekove i korišćenje bez nadzora veterinara. Dobijeni podaci pokazuju da je nivo
svestu uzgajivača stoke u regionu Sjenice nizak jer koriste veterinarske lekove bez nadzora
veterinara. Najčešće koriste antibiotike, streptomicin i benzoil-penicilin, antihelmintik –
abendazol i, iznenađujuće, koriste formaldehid za dezinfekciju prostorija za smeštaj
životinja, pri čemu ga smatraju veterinarskim lekom. Zbog rasprostranjene upoutrebe
veterinarskih lekova u regionu Sjenice od strane uzgajivača stoke, a bez kontrole veterinara
preporučuje se monitoring streptomicina, benzoilpenicilina i abendazola kao i njihovih
metabolita u životnoj sredini, zemljištu i vodi. Potrebno je preduzeti dodatne mere opreza da
zbog niskog nivoa svesti ne bi došlo do izloženosti ljudi ovim veterinarskim lekovima i
njihovim metabolitima naročito zbog neadekvatnog tretiranja stajnjaka i drugog otpada.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Awareness on the use of veterinary drugs in the region of Sjenica as potential environmental pollutants, Svest o korišćenju veterinarskih lekova u regionu Sjenice kao potencijalnih zagađivača životne sredine",
volume = "72",
number = "4 suplement",
pages = "S577-S578",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4627"
}

Ćurčić, M., Ćatović, R., Ćirović, T., Stojilković, N., Buha-Đorđević, A., Antonijević-Miljaković, E., Đukić-Ćosić, D., Javorac, D., Baralić, K., Bulat, Z.,& Antonijević, B.. (2022). Awareness on the use of veterinary drugs in the region of Sjenica as potential environmental pollutants. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S577-S578.
https://hdl.handle.net/21.15107/rcub_farfar_4627

Ćurčić M, Ćatović R, Ćirović T, Stojilković N, Buha-Đorđević A, Antonijević-Miljaković E, Đukić-Ćosić D, Javorac D, Baralić K, Bulat Z, Antonijević B. Awareness on the use of veterinary drugs in the region of Sjenica as potential environmental pollutants. in Arhiv za farmaciju. 2022;72(4 suplement):S577-S578.
https://hdl.handle.net/21.15107/rcub_farfar_4627 .

Ćurčić, Marijana, Ćatović, Rialda, Ćirović, Tatjana, Stojilković, Nikola, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Javorac, Dragana, Baralić, Katarina, Bulat, Zorica, Antonijević, Biljana, "Awareness on the use of veterinary drugs in the region of Sjenica as potential environmental pollutants" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S577-S578,
https://hdl.handle.net/21.15107/rcub_farfar_4627 .

TY  - CONF
AU  - Antonijević, Biljana
AU  - Stojilković, Nikola
AU  - Prancic, B
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4348
PB  - Elsevier B.V.
C3  - Toxicology Letters
T1  - Endocrine-disrupting potential of lead, cadmium, mercury and PCBs mixture: in silico toxicogenomic case study
VL  - 368
IS  - Supplement
SP  - S215
EP  - S216
DO  - 10.1016/j.toxlet.2022.07.586
ER  - 

@conference{
author = "Antonijević, Biljana and Stojilković, Nikola and Prancic, B and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Javorac, Dragana and Baralić, Katarina and Marić, Đurđica and Bulat, Zorica and Đukić-Ćosić, Danijela",
year = "2022",
publisher = "Elsevier B.V.",
journal = "Toxicology Letters",
title = "Endocrine-disrupting potential of lead, cadmium, mercury and PCBs mixture: in silico toxicogenomic case study",
volume = "368",
number = "Supplement",
pages = "S215-S216",
doi = "10.1016/j.toxlet.2022.07.586"
}

Antonijević, B., Stojilković, N., Prancic, B., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Javorac, D., Baralić, K., Marić, Đ., Bulat, Z.,& Đukić-Ćosić, D.. (2022). Endocrine-disrupting potential of lead, cadmium, mercury and PCBs mixture: in silico toxicogenomic case study. in Toxicology Letters
Elsevier B.V.., 368(Supplement), S215-S216.
https://doi.org/10.1016/j.toxlet.2022.07.586

Antonijević B, Stojilković N, Prancic B, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Javorac D, Baralić K, Marić Đ, Bulat Z, Đukić-Ćosić D. Endocrine-disrupting potential of lead, cadmium, mercury and PCBs mixture: in silico toxicogenomic case study. in Toxicology Letters. 2022;368(Supplement):S215-S216.
doi:10.1016/j.toxlet.2022.07.586 .

Antonijević, Biljana, Stojilković, Nikola, Prancic, B, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Javorac, Dragana, Baralić, Katarina, Marić, Đurđica, Bulat, Zorica, Đukić-Ćosić, Danijela, "Endocrine-disrupting potential of lead, cadmium, mercury and PCBs mixture: in silico toxicogenomic case study" in Toxicology Letters, 368, no. Supplement (2022):S215-S216,
https://doi.org/10.1016/j.toxlet.2022.07.586 . .

TY  - JOUR
AU  - Đukić-Ćosić, Danijela
AU  - Baralić, Katarina
AU  - Jorgovanović, Dragica
AU  - Živančević, Katarina
AU  - Javorac, Dragana
AU  - Stojilković, Nikola
AU  - Radović, Biljana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević-Miljaković, Evica
AU  - Antonijević, Biljana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3958
AB  - While experimental animal investigation has historically been the most conventional
approach conducted to assess drug safety and is currently considered the main method for
determining drug toxicity, these studies are constricted by cost, time, and ethical approvals. Over
the last 20 years, there have been significant advances in computational sciences and computer
data processing, while knowledge of alternative techniques and their application has developed
into a valuable skill in toxicology. Thus, the application of in silico methods in drug safety
assessment is constantly increasing. They are very complex and are grounded on accumulated
knowledge from toxicology, bioinformatics, biochemistry, statistics, mathematics, as well as
molecular biology. This review will summarize current state-of-the-art scientific data on the use
of in silico methods in toxicity testing, taking into account their shortcomings, and highlighting
the strategies that should deliver consistent results, while covering the applications of in silico
methods in preclinical trials and drug impurities toxicity testing.
AB  - Ispitivanja na eksperimentalnim životinjama ne samo da su u prošlosti bila smatrana najkonvencionalnijim pristupom za procenu bezbednosti lekova, već su i trenutno osnovna metoda za utvrđivanje njihove toksičnosti. Međutim, ova ispitivanja su skupa, vremenski zahtevna i za njihovo sprovođenje neophodne su etičke dozvole. Tokom poslednjih 20 godina došlo je do napretka u računarskoj nauci i kompjuterskoj obradi podataka, dok se znanje o alternativnim tehnikama i njihovoj primeni razvilo u dragocenu veštinu u toksikologiji. Stoga, primena in silico metoda u proceni bezbednosti lekova neprestano raste. Ove metode su veoma složene i zasnivaju se na saznanjima iz toksikologije, bioinformatike, biohemije, statistike, matematike i molekularne biologije. Ovaj pregledni rad će rezimirati trenutna naučna saznanja koja se tiču upotrebe in silico metoda u ispitivanju toksičnosti lekova, uzimajući u obzir njihova ograničenja i ističući strategije pomoću kojih se mogu dobiti konzistentni rezultati, sa posebnim osvrtom na primenu in silico metoda u pretkliničkim ispitivanjima i ispitivanjima toksičnosti nečistoća u lekovima.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - In silico toxicology methods in drug safety assessment
T1  - "In silico" metode u toksikologiji za procenu bezbednosti lekova
VL  - 71
IS  - 4
SP  - 257
EP  - 278
DO  - 10.5937/arhfarm71-32966
ER  - 

@article{
author = "Đukić-Ćosić, Danijela and Baralić, Katarina and Jorgovanović, Dragica and Živančević, Katarina and Javorac, Dragana and Stojilković, Nikola and Radović, Biljana and Marić, Đurđica and Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević-Miljaković, Evica and Antonijević, Biljana",
year = "2021",
abstract = "While experimental animal investigation has historically been the most conventional
approach conducted to assess drug safety and is currently considered the main method for
determining drug toxicity, these studies are constricted by cost, time, and ethical approvals. Over
the last 20 years, there have been significant advances in computational sciences and computer
data processing, while knowledge of alternative techniques and their application has developed
into a valuable skill in toxicology. Thus, the application of in silico methods in drug safety
assessment is constantly increasing. They are very complex and are grounded on accumulated
knowledge from toxicology, bioinformatics, biochemistry, statistics, mathematics, as well as
molecular biology. This review will summarize current state-of-the-art scientific data on the use
of in silico methods in toxicity testing, taking into account their shortcomings, and highlighting
the strategies that should deliver consistent results, while covering the applications of in silico
methods in preclinical trials and drug impurities toxicity testing., Ispitivanja na eksperimentalnim životinjama ne samo da su u prošlosti bila smatrana najkonvencionalnijim pristupom za procenu bezbednosti lekova, već su i trenutno osnovna metoda za utvrđivanje njihove toksičnosti. Međutim, ova ispitivanja su skupa, vremenski zahtevna i za njihovo sprovođenje neophodne su etičke dozvole. Tokom poslednjih 20 godina došlo je do napretka u računarskoj nauci i kompjuterskoj obradi podataka, dok se znanje o alternativnim tehnikama i njihovoj primeni razvilo u dragocenu veštinu u toksikologiji. Stoga, primena in silico metoda u proceni bezbednosti lekova neprestano raste. Ove metode su veoma složene i zasnivaju se na saznanjima iz toksikologije, bioinformatike, biohemije, statistike, matematike i molekularne biologije. Ovaj pregledni rad će rezimirati trenutna naučna saznanja koja se tiču upotrebe in silico metoda u ispitivanju toksičnosti lekova, uzimajući u obzir njihova ograničenja i ističući strategije pomoću kojih se mogu dobiti konzistentni rezultati, sa posebnim osvrtom na primenu in silico metoda u pretkliničkim ispitivanjima i ispitivanjima toksičnosti nečistoća u lekovima.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "In silico toxicology methods in drug safety assessment, "In silico" metode u toksikologiji za procenu bezbednosti lekova",
volume = "71",
number = "4",
pages = "257-278",
doi = "10.5937/arhfarm71-32966"
}

Đukić-Ćosić, D., Baralić, K., Jorgovanović, D., Živančević, K., Javorac, D., Stojilković, N., Radović, B., Marić, Đ., Ćurčić, M., Buha-Đorđević, A., Bulat, Z., Antonijević-Miljaković, E.,& Antonijević, B.. (2021). In silico toxicology methods in drug safety assessment. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 71(4), 257-278.
https://doi.org/10.5937/arhfarm71-32966

Đukić-Ćosić D, Baralić K, Jorgovanović D, Živančević K, Javorac D, Stojilković N, Radović B, Marić Đ, Ćurčić M, Buha-Đorđević A, Bulat Z, Antonijević-Miljaković E, Antonijević B. In silico toxicology methods in drug safety assessment. in Arhiv za farmaciju. 2021;71(4):257-278.
doi:10.5937/arhfarm71-32966 .

Đukić-Ćosić, Danijela, Baralić, Katarina, Jorgovanović, Dragica, Živančević, Katarina, Javorac, Dragana, Stojilković, Nikola, Radović, Biljana, Marić, Đurđica, Ćurčić, Marijana, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević-Miljaković, Evica, Antonijević, Biljana, "In silico toxicology methods in drug safety assessment" in Arhiv za farmaciju, 71, no. 4 (2021):257-278,
https://doi.org/10.5937/arhfarm71-32966 . .