TY  - JOUR
AU  - Čudina, Olivera
AU  - Brborić, Jasmina
AU  - Janković, I.
AU  - Karljiković-Rajić, Katarina
AU  - Vladimirova, S.
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1090
AB  - In this study, the interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on spectroscopic and acid-base properties of VAL was carried out using UV spectrophotometry at physiological conditions (pH 7.4). The binding of VAL to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.69) proving the great affinity of VAL dianion for the positively charged CTAB micelle surface. To quantify the degree of VAL/CTAB interaction, two constants were calculated by using mathematical models: micelle/water partition coefficient (K-x) and drug/micelle binding constant (K-b). The decrease of K-x with VAL concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 295 nm on CTAB concentration, by using mathematical model that treats the solubilization of VAL dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant (K-b = (2.50 +/- 10.49) x 10(4) M-1) was obtained. Binding constant VAL/CTAB was also calculated using micellar liquid chromatography (MLC).
PB  - Elsevier Science BV, Amsterdam
T2  - Colloids and Surfaces B: Biointerfaces
T1  - Study of valsartan interaction with micelles as a model system for biomembranes
VL  - 65
IS  - 1
SP  - 80
EP  - 84
DO  - 10.1016/j.colsurfb.2008.03.002
ER  - 

@article{
author = "Čudina, Olivera and Brborić, Jasmina and Janković, I. and Karljiković-Rajić, Katarina and Vladimirova, S.",
year = "2008",
abstract = "In this study, the interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on spectroscopic and acid-base properties of VAL was carried out using UV spectrophotometry at physiological conditions (pH 7.4). The binding of VAL to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.69) proving the great affinity of VAL dianion for the positively charged CTAB micelle surface. To quantify the degree of VAL/CTAB interaction, two constants were calculated by using mathematical models: micelle/water partition coefficient (K-x) and drug/micelle binding constant (K-b). The decrease of K-x with VAL concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 295 nm on CTAB concentration, by using mathematical model that treats the solubilization of VAL dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant (K-b = (2.50 +/- 10.49) x 10(4) M-1) was obtained. Binding constant VAL/CTAB was also calculated using micellar liquid chromatography (MLC).",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Study of valsartan interaction with micelles as a model system for biomembranes",
volume = "65",
number = "1",
pages = "80-84",
doi = "10.1016/j.colsurfb.2008.03.002"
}

Čudina, O., Brborić, J., Janković, I., Karljiković-Rajić, K.,& Vladimirova, S.. (2008). Study of valsartan interaction with micelles as a model system for biomembranes. in Colloids and Surfaces B: Biointerfaces
Elsevier Science BV, Amsterdam., 65(1), 80-84.
https://doi.org/10.1016/j.colsurfb.2008.03.002

Čudina O, Brborić J, Janković I, Karljiković-Rajić K, Vladimirova S. Study of valsartan interaction with micelles as a model system for biomembranes. in Colloids and Surfaces B: Biointerfaces. 2008;65(1):80-84.
doi:10.1016/j.colsurfb.2008.03.002 .

Čudina, Olivera, Brborić, Jasmina, Janković, I., Karljiković-Rajić, Katarina, Vladimirova, S., "Study of valsartan interaction with micelles as a model system for biomembranes" in Colloids and Surfaces B: Biointerfaces, 65, no. 1 (2008):80-84,
https://doi.org/10.1016/j.colsurfb.2008.03.002 . .

TY  - CONF
AU  - Čudina, Olivera
AU  - Janković, I.
AU  - Karljiković-Rajić, Katarina
AU  - Vladimirov, S.
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/720
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - An interaction study of valsartan/cationic surfactant using absorption UV spectrophotometry
T1  - Ispitivanje interakcija valsartan/katjonski surfaktant primenom apsorpcione UV spektrofotometrije
VL  - 56
IS  - 5
SP  - 690
EP  - 691
UR  - https://hdl.handle.net/21.15107/rcub_farfar_720
ER  - 

@conference{
author = "Čudina, Olivera and Janković, I. and Karljiković-Rajić, Katarina and Vladimirov, S.",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "An interaction study of valsartan/cationic surfactant using absorption UV spectrophotometry, Ispitivanje interakcija valsartan/katjonski surfaktant primenom apsorpcione UV spektrofotometrije",
volume = "56",
number = "5",
pages = "690-691",
url = "https://hdl.handle.net/21.15107/rcub_farfar_720"
}

Čudina, O., Janković, I., Karljiković-Rajić, K.,& Vladimirov, S.. (2006). An interaction study of valsartan/cationic surfactant using absorption UV spectrophotometry. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(5), 690-691.
https://hdl.handle.net/21.15107/rcub_farfar_720

Čudina O, Janković I, Karljiković-Rajić K, Vladimirov S. An interaction study of valsartan/cationic surfactant using absorption UV spectrophotometry. in Arhiv za farmaciju. 2006;56(5):690-691.
https://hdl.handle.net/21.15107/rcub_farfar_720 .

Čudina, Olivera, Janković, I., Karljiković-Rajić, Katarina, Vladimirov, S., "An interaction study of valsartan/cationic surfactant using absorption UV spectrophotometry" in Arhiv za farmaciju, 56, no. 5 (2006):690-691,
https://hdl.handle.net/21.15107/rcub_farfar_720 .

TY  - JOUR
AU  - Čudina, Olivera
AU  - Karljiković-Rajić, Katarina
AU  - Ruvarac-Bugarcić, I
AU  - Janković, I
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/592
AB  - In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3).
PB  - Elsevier Science BV, Amsterdam
T2  - Colloids and Surfaces A: Physicochemical and Engineering Aspects
T1  - Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide
VL  - 256
IS  - 2-3
SP  - 225
EP  - 232
DO  - 10.1016/j.colsurfa.2005.01.023
ER  - 

@article{
author = "Čudina, Olivera and Karljiković-Rajić, Katarina and Ruvarac-Bugarcić, I and Janković, I",
year = "2005",
abstract = "In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3).",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",
title = "Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide",
volume = "256",
number = "2-3",
pages = "225-232",
doi = "10.1016/j.colsurfa.2005.01.023"
}

Čudina, O., Karljiković-Rajić, K., Ruvarac-Bugarcić, I.,& Janković, I.. (2005). Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide. in Colloids and Surfaces A: Physicochemical and Engineering Aspects
Elsevier Science BV, Amsterdam., 256(2-3), 225-232.
https://doi.org/10.1016/j.colsurfa.2005.01.023

Čudina O, Karljiković-Rajić K, Ruvarac-Bugarcić I, Janković I. Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide. in Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2005;256(2-3):225-232.
doi:10.1016/j.colsurfa.2005.01.023 .

Čudina, Olivera, Karljiković-Rajić, Katarina, Ruvarac-Bugarcić, I, Janković, I, "Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide" in Colloids and Surfaces A: Physicochemical and Engineering Aspects, 256, no. 2-3 (2005):225-232,
https://doi.org/10.1016/j.colsurfa.2005.01.023 . .

TY  - JOUR
AU  - Velikinac, I
AU  - Čudina, Olivera
AU  - Janković, I
AU  - Agbaba, Danica
AU  - Vladimirov, S
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/554
AB  - A capillary zone electrophoresis (CZE) and a high-performance liquid chromatography (HPLC) method have been developed for identification and determination of ketoconazole, an imidazole antifungal, in pharmaceutical preparations. The suitabilities of both methods for quantitative determination of ketoconazole were approved through validation specification such as linearity, precision, accuracy, limit of detection and quantification. The proposed methods were used for determination of ketoconazole in commercial pharmaceutical dosage forms (tablets and creams). Under described conditions, CZE method is more selective, while the HPLC method is more sensitive. Both methods are rapid (t R (CZE)=5.14 min and t R (HPLC)=2.66 min), which is important for routine application. However, the HPLC method provides a repeatability of the quantitative analysis of ketoconazole in drug formulations below 1.5% relative standard deviation (R.S.D), while the repeatability of the CZE method is in the order of 2-3% R.S.D.
PB  - Elsevier Masson SAS
T2  - Farmaco
T1  - Comparison of capillary zone electrophoresis and high performance liquid chromatography methods for quantitative determination of ketoconazole in drug formulations
VL  - 59
IS  - 5
SP  - 419
EP  - 424
DO  - 10.1016/j.farmac.2003.11.019
ER  - 

@article{
author = "Velikinac, I and Čudina, Olivera and Janković, I and Agbaba, Danica and Vladimirov, S",
year = "2004",
abstract = "A capillary zone electrophoresis (CZE) and a high-performance liquid chromatography (HPLC) method have been developed for identification and determination of ketoconazole, an imidazole antifungal, in pharmaceutical preparations. The suitabilities of both methods for quantitative determination of ketoconazole were approved through validation specification such as linearity, precision, accuracy, limit of detection and quantification. The proposed methods were used for determination of ketoconazole in commercial pharmaceutical dosage forms (tablets and creams). Under described conditions, CZE method is more selective, while the HPLC method is more sensitive. Both methods are rapid (t R (CZE)=5.14 min and t R (HPLC)=2.66 min), which is important for routine application. However, the HPLC method provides a repeatability of the quantitative analysis of ketoconazole in drug formulations below 1.5% relative standard deviation (R.S.D), while the repeatability of the CZE method is in the order of 2-3% R.S.D.",
publisher = "Elsevier Masson SAS",
journal = "Farmaco",
title = "Comparison of capillary zone electrophoresis and high performance liquid chromatography methods for quantitative determination of ketoconazole in drug formulations",
volume = "59",
number = "5",
pages = "419-424",
doi = "10.1016/j.farmac.2003.11.019"
}

Velikinac, I., Čudina, O., Janković, I., Agbaba, D.,& Vladimirov, S.. (2004). Comparison of capillary zone electrophoresis and high performance liquid chromatography methods for quantitative determination of ketoconazole in drug formulations. in Farmaco
Elsevier Masson SAS., 59(5), 419-424.
https://doi.org/10.1016/j.farmac.2003.11.019

Velikinac I, Čudina O, Janković I, Agbaba D, Vladimirov S. Comparison of capillary zone electrophoresis and high performance liquid chromatography methods for quantitative determination of ketoconazole in drug formulations. in Farmaco. 2004;59(5):419-424.
doi:10.1016/j.farmac.2003.11.019 .

Velikinac, I, Čudina, Olivera, Janković, I, Agbaba, Danica, Vladimirov, S, "Comparison of capillary zone electrophoresis and high performance liquid chromatography methods for quantitative determination of ketoconazole in drug formulations" in Farmaco, 59, no. 5 (2004):419-424,
https://doi.org/10.1016/j.farmac.2003.11.019 . .