TY  - JOUR
AU  - Tomić, Tanja
AU  - Henman, Martin
AU  - Tadić, Ivana
AU  - Antić-Stanković, Jelena
AU  - Santric Milicevic, Milena
AU  - Bukumirić, Zoran
AU  - Lakić, Dragana
AU  - Odalović, Marina
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5653
AB  - Introduction: The coronavirus disease 2019 (COVID-19) pandemic affected antibiotic usage worldwide. However, there is limited data from Serbia. Dispensing of oral antibiotics in Serbian pharmacies was analyzed to calculate monthly and yearly changes between 2018-2021, and to explore immediate and long-term effects of COVID-19 on antibiotic dispensing during this period. Methodology: The number of antibiotic packages dispensed from pharmacies during the study period was analyzed with a Chi-square test to assess the average change in annual dispensing, and an interrupted time-series analysis was used to evaluate the impact of the pandemic on antibiotic dispensing. The data from 2018-2021 were retrieved from the database of a large community pharmacy chain in Serbia. Results: The average number of antibiotic packages dispensed per day and per pharmacy was higher in 2021 compared to 2018 by one package. However, the dispensing of macrolides increased significantly; 17.7% (2018) vs. 22.5% (2021) (p < 0.05). In general, an increase in antibiotic dispensing was detected during COVID-19 for total antibiotics (16.4%), Watch antibiotics (44.8%), third-generation cephalosporins (80.4%), macrolides (45.5%) and azithromycin (83.7%). However, the immediate effect of COVID-19 was a decrease in the dispensing of Watch antibiotics, penicillin, and third-generation cephalosporins (p < 0.05); and a notable long-term COVID-19 effect was an increase in the dispensing of azithromycin (p < 0.05). Conclusions: In spite of a relatively stable trend of total antibiotic dispensing before and during COVID-19 pandemic, the use of Watch antibiotics, third-generation cephalosporins, and macrolides (particularly azithromycin) showed an increasing trend in dispensing that should be optimized.
PB  - Journal of Infection in Developing Countries
T2  - Journal of Infection in Developing Countries
T1  - Immediate and long-term effects of COVID-19 on antibiotic dispensing: increasing use of Watch antibiotics
VL  - 18
IS  - 4
SP  - 504
EP  - 512
DO  - 10.3855/jidc.19255
ER  - 

@article{
author = "Tomić, Tanja and Henman, Martin and Tadić, Ivana and Antić-Stanković, Jelena and Santric Milicevic, Milena and Bukumirić, Zoran and Lakić, Dragana and Odalović, Marina",
year = "2024",
abstract = "Introduction: The coronavirus disease 2019 (COVID-19) pandemic affected antibiotic usage worldwide. However, there is limited data from Serbia. Dispensing of oral antibiotics in Serbian pharmacies was analyzed to calculate monthly and yearly changes between 2018-2021, and to explore immediate and long-term effects of COVID-19 on antibiotic dispensing during this period. Methodology: The number of antibiotic packages dispensed from pharmacies during the study period was analyzed with a Chi-square test to assess the average change in annual dispensing, and an interrupted time-series analysis was used to evaluate the impact of the pandemic on antibiotic dispensing. The data from 2018-2021 were retrieved from the database of a large community pharmacy chain in Serbia. Results: The average number of antibiotic packages dispensed per day and per pharmacy was higher in 2021 compared to 2018 by one package. However, the dispensing of macrolides increased significantly; 17.7% (2018) vs. 22.5% (2021) (p < 0.05). In general, an increase in antibiotic dispensing was detected during COVID-19 for total antibiotics (16.4%), Watch antibiotics (44.8%), third-generation cephalosporins (80.4%), macrolides (45.5%) and azithromycin (83.7%). However, the immediate effect of COVID-19 was a decrease in the dispensing of Watch antibiotics, penicillin, and third-generation cephalosporins (p < 0.05); and a notable long-term COVID-19 effect was an increase in the dispensing of azithromycin (p < 0.05). Conclusions: In spite of a relatively stable trend of total antibiotic dispensing before and during COVID-19 pandemic, the use of Watch antibiotics, third-generation cephalosporins, and macrolides (particularly azithromycin) showed an increasing trend in dispensing that should be optimized.",
publisher = "Journal of Infection in Developing Countries",
journal = "Journal of Infection in Developing Countries",
title = "Immediate and long-term effects of COVID-19 on antibiotic dispensing: increasing use of Watch antibiotics",
volume = "18",
number = "4",
pages = "504-512",
doi = "10.3855/jidc.19255"
}

Tomić, T., Henman, M., Tadić, I., Antić-Stanković, J., Santric Milicevic, M., Bukumirić, Z., Lakić, D.,& Odalović, M.. (2024). Immediate and long-term effects of COVID-19 on antibiotic dispensing: increasing use of Watch antibiotics. in Journal of Infection in Developing Countries
Journal of Infection in Developing Countries., 18(4), 504-512.
https://doi.org/10.3855/jidc.19255

Tomić T, Henman M, Tadić I, Antić-Stanković J, Santric Milicevic M, Bukumirić Z, Lakić D, Odalović M. Immediate and long-term effects of COVID-19 on antibiotic dispensing: increasing use of Watch antibiotics. in Journal of Infection in Developing Countries. 2024;18(4):504-512.
doi:10.3855/jidc.19255 .

Tomić, Tanja, Henman, Martin, Tadić, Ivana, Antić-Stanković, Jelena, Santric Milicevic, Milena, Bukumirić, Zoran, Lakić, Dragana, Odalović, Marina, "Immediate and long-term effects of COVID-19 on antibiotic dispensing: increasing use of Watch antibiotics" in Journal of Infection in Developing Countries, 18, no. 4 (2024):504-512,
https://doi.org/10.3855/jidc.19255 . .

TY  - JOUR
AU  - Tomić, Tanja
AU  - Henman, Martin
AU  - Tadić, Ivana
AU  - Antić-Stanković, Jelena
AU  - Santric Milicević, Milena
AU  - Maksimović, Nataša
AU  - Odalović, Marina
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4832
AB  - Background In Europe, Serbia occupies a high position in antibiotic utilization and antimicrobial resistance (AMR). Aim The aim was to analyse utilization trends of meropenem, ceftazidime, aminoglycosides, piperacillin/tazobactam and fluoroquinolones (2006–2020), and the reported AMR in Pseudomonas aeruginosa (2013–2020) in Serbia and to compare with data from eight European countries (2015–2020). Method Joinpoint regression was used to analyse antibiotic utilization data (2006–2020) and the reported AMR in Pseu- domonas aeruginosa (2013–2020). Data sources were relevant national and international institutions. Antibiotic utilization and AMR in Pseudomonas aeruginosa data in Serbia were compared with eight European countries. Results There was a significantly increased trend for ceftazidime utilization and reported resistance in Pseudomonas aer- uginosa, Serbia (p < 0.05) (2018–2020). For ceftazidime, piperacillin/tazobactam, and fluoroquinolones resistances in Pseu- domonas aeruginosa an increased trend was observed, Serbia (2013–2020). A decrease in both the utilization of aminogly- cosides, Serbia (p < 0.05) (2006–2018) and contemporaneous Pseudomonas aeruginosa resistance (p > 0.05) was detected. Fluoroquinolone utilization (2015–2020) was highest in Serbia compared to Netherlands and Finland, 310 and 305% higher, similar compared to Romania, and 2% less compared to Montenegro. Aminoglycosides (2015–2020) were 2550 and 783% more used in Serbia compared to Finland and Netherlands, and 38% less regarding Montenegro. The highest percentage of Pseudomonas aeruginosa resistance was in Romania and Serbia (2015–2020). Conclusion The use of piperacillin/tazobactam, ceftazidime and fluoroquinolones should be carefully monitored in clinical practice due to increased Pseudomonas aeruginosa resistance. The level of utilization and AMR in Pseudomonas aeruginosa is still high in Serbia compared to other European countries.
PB  - Springer
T2  - International Journal of Clinical Pharmacy
T1  - Antimicrobial utilization and resistance in Pseudomonas aeruginosa using segmented regression analysis: a comparative study between Serbia and eight European Countries
DO  - 10.1007/s11096-023-01603-y
ER  - 

@article{
author = "Tomić, Tanja and Henman, Martin and Tadić, Ivana and Antić-Stanković, Jelena and Santric Milicević, Milena and Maksimović, Nataša and Odalović, Marina",
year = "2023",
abstract = "Background In Europe, Serbia occupies a high position in antibiotic utilization and antimicrobial resistance (AMR). Aim The aim was to analyse utilization trends of meropenem, ceftazidime, aminoglycosides, piperacillin/tazobactam and fluoroquinolones (2006–2020), and the reported AMR in Pseudomonas aeruginosa (2013–2020) in Serbia and to compare with data from eight European countries (2015–2020). Method Joinpoint regression was used to analyse antibiotic utilization data (2006–2020) and the reported AMR in Pseu- domonas aeruginosa (2013–2020). Data sources were relevant national and international institutions. Antibiotic utilization and AMR in Pseudomonas aeruginosa data in Serbia were compared with eight European countries. Results There was a significantly increased trend for ceftazidime utilization and reported resistance in Pseudomonas aer- uginosa, Serbia (p < 0.05) (2018–2020). For ceftazidime, piperacillin/tazobactam, and fluoroquinolones resistances in Pseu- domonas aeruginosa an increased trend was observed, Serbia (2013–2020). A decrease in both the utilization of aminogly- cosides, Serbia (p < 0.05) (2006–2018) and contemporaneous Pseudomonas aeruginosa resistance (p > 0.05) was detected. Fluoroquinolone utilization (2015–2020) was highest in Serbia compared to Netherlands and Finland, 310 and 305% higher, similar compared to Romania, and 2% less compared to Montenegro. Aminoglycosides (2015–2020) were 2550 and 783% more used in Serbia compared to Finland and Netherlands, and 38% less regarding Montenegro. The highest percentage of Pseudomonas aeruginosa resistance was in Romania and Serbia (2015–2020). Conclusion The use of piperacillin/tazobactam, ceftazidime and fluoroquinolones should be carefully monitored in clinical practice due to increased Pseudomonas aeruginosa resistance. The level of utilization and AMR in Pseudomonas aeruginosa is still high in Serbia compared to other European countries.",
publisher = "Springer",
journal = "International Journal of Clinical Pharmacy",
title = "Antimicrobial utilization and resistance in Pseudomonas aeruginosa using segmented regression analysis: a comparative study between Serbia and eight European Countries",
doi = "10.1007/s11096-023-01603-y"
}

Tomić, T., Henman, M., Tadić, I., Antić-Stanković, J., Santric Milicević, M., Maksimović, N.,& Odalović, M.. (2023). Antimicrobial utilization and resistance in Pseudomonas aeruginosa using segmented regression analysis: a comparative study between Serbia and eight European Countries. in International Journal of Clinical Pharmacy
Springer..
https://doi.org/10.1007/s11096-023-01603-y

Tomić T, Henman M, Tadić I, Antić-Stanković J, Santric Milicević M, Maksimović N, Odalović M. Antimicrobial utilization and resistance in Pseudomonas aeruginosa using segmented regression analysis: a comparative study between Serbia and eight European Countries. in International Journal of Clinical Pharmacy. 2023;.
doi:10.1007/s11096-023-01603-y .

Tomić, Tanja, Henman, Martin, Tadić, Ivana, Antić-Stanković, Jelena, Santric Milicević, Milena, Maksimović, Nataša, Odalović, Marina, "Antimicrobial utilization and resistance in Pseudomonas aeruginosa using segmented regression analysis: a comparative study between Serbia and eight European Countries" in International Journal of Clinical Pharmacy (2023),
https://doi.org/10.1007/s11096-023-01603-y . .

TY  - CONF
AU  - Lakić, Dragana
AU  - Odalović, Marina
AU  - Jakovljević, Vladimir
AU  - Arsić, Ivana A.
AU  - Komazec, Zoran
AU  - Tasić, Ljiljana
AU  - Parojčić, Jelena
AU  - Cavaco, Afonso
AU  - Henman, Martin
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3179
PB  - Springer
C3  - International Journal of Clinical Pharmacy
T1  - Advancement in pharmacy education-professional practice in university curricula in Serbia
VL  - 40
IS  - 1
SP  - 242
EP  - 243
DO  - 10.1007/s11096-017-0565-9
ER  - 

@conference{
author = "Lakić, Dragana and Odalović, Marina and Jakovljević, Vladimir and Arsić, Ivana A. and Komazec, Zoran and Tasić, Ljiljana and Parojčić, Jelena and Cavaco, Afonso and Henman, Martin",
year = "2018",
publisher = "Springer",
journal = "International Journal of Clinical Pharmacy",
title = "Advancement in pharmacy education-professional practice in university curricula in Serbia",
volume = "40",
number = "1",
pages = "242-243",
doi = "10.1007/s11096-017-0565-9"
}

Lakić, D., Odalović, M., Jakovljević, V., Arsić, I. A., Komazec, Z., Tasić, L., Parojčić, J., Cavaco, A.,& Henman, M.. (2018). Advancement in pharmacy education-professional practice in university curricula in Serbia. in International Journal of Clinical Pharmacy
Springer., 40(1), 242-243.
https://doi.org/10.1007/s11096-017-0565-9

Lakić D, Odalović M, Jakovljević V, Arsić IA, Komazec Z, Tasić L, Parojčić J, Cavaco A, Henman M. Advancement in pharmacy education-professional practice in university curricula in Serbia. in International Journal of Clinical Pharmacy. 2018;40(1):242-243.
doi:10.1007/s11096-017-0565-9 .

Lakić, Dragana, Odalović, Marina, Jakovljević, Vladimir, Arsić, Ivana A., Komazec, Zoran, Tasić, Ljiljana, Parojčić, Jelena, Cavaco, Afonso, Henman, Martin, "Advancement in pharmacy education-professional practice in university curricula in Serbia" in International Journal of Clinical Pharmacy, 40, no. 1 (2018):242-243,
https://doi.org/10.1007/s11096-017-0565-9 . .