@article{
author = "Salkić, Alma and Otašević, Biljana and Rašević, Marija and Zečević, Mira",
year = "2023",
abstract = "A selective eco-friendly micellar HPLC method was developed for investigation of moxifloxacin and related compounds in the presence of its degradation products. Central composite design was used to optimize the experimental conditions. The proposed method is based on isocratic elution on a C18 column using 92.5% (v/v) biodegradable aqueous mobile phase containing 0.01 M sodium dihydrogen phosphate, 0.15 M sodium dodecyl sulfate (SDS) and 0.5% triethylamine (v/v) with a pH of 3.5 and 7.5% isopropanol (v/v) as eco- friendly organic solvent. The flow rate and injection volume were 0.6 ml/min and 5 µl, respectively. Experiments were performed at a temperature of 60 °C and detection was performed at 295 nm. The optimized method was validated. The method was found to be suitable for the quantification of moxifloxacin and its related compounds in moxifloxacin drug substance. The Green Analytical Procedure Index (GAPI) proves the superiority of the developed method against other reported methods.",
publisher = "Slovensko Kemijsko Drustvo",
journal = "Acta Chimica Slovenica",
title = "Micellar Liquid Chromatographic Method for Determination of Moxifloxacin and its Impurities",
volume = "70",
number = "3",
pages = "385-397",
doi = "10.17344/acsi.2023.8022"
}