TY  - JOUR
AU  - Vemić, Ana
AU  - Malenović, Anđelija
AU  - Rakić, Tijana
AU  - Kostić, Nada M.
AU  - Jančić-Stojanović, Biljana
AU  - Ivanović, Darko
AU  - Medenica, Mirjana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1681
AB  - Microemulsions when used as mobile phases represent a very powerful chromatographic tool due to their polyphase structure. The aim of this study was to investigate the influence of the mobile phase composition and resulting microemulsion droplet's properties, as well as the stationary phase lipophilicity on the chromatographic behavior of pramipexole and its five impurities. Investigation was carried out according to the experimental plan defined by a full factorial design 2(4) with four central point replications. While the most affected by column characteristics was the last eluting, most lipophilic substance, the composition and characteristics of microemulsion droplets were equally important, so the partition system microemulsion droplets/stationary phase proved to be the most significant. Stationary phase lipophilicity did not affect the most hydrophilic component and only the partition system microemulsion droplets/bulk of the eluent impacted its behavior. For the separation of the critical pair, almost equal effects of the microemulsion droplets/stationary phase and bulk of the eluent/stationary phase partition systems were noted.
PB  - Soc Brasileira Quimica, Sao Paulo
T2  - Journal of the Brazilian Chemical Society
T1  - Physicochemical Factors Governing the Partition of Pramipexole and Its Five Impurities in Microemulsion Liquid Chromatographic Systems
VL  - 23
IS  - 11
SP  - 2084
EP  - 2092
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1681
ER  - 

@article{
author = "Vemić, Ana and Malenović, Anđelija and Rakić, Tijana and Kostić, Nada M. and Jančić-Stojanović, Biljana and Ivanović, Darko and Medenica, Mirjana",
year = "2012",
abstract = "Microemulsions when used as mobile phases represent a very powerful chromatographic tool due to their polyphase structure. The aim of this study was to investigate the influence of the mobile phase composition and resulting microemulsion droplet's properties, as well as the stationary phase lipophilicity on the chromatographic behavior of pramipexole and its five impurities. Investigation was carried out according to the experimental plan defined by a full factorial design 2(4) with four central point replications. While the most affected by column characteristics was the last eluting, most lipophilic substance, the composition and characteristics of microemulsion droplets were equally important, so the partition system microemulsion droplets/stationary phase proved to be the most significant. Stationary phase lipophilicity did not affect the most hydrophilic component and only the partition system microemulsion droplets/bulk of the eluent impacted its behavior. For the separation of the critical pair, almost equal effects of the microemulsion droplets/stationary phase and bulk of the eluent/stationary phase partition systems were noted.",
publisher = "Soc Brasileira Quimica, Sao Paulo",
journal = "Journal of the Brazilian Chemical Society",
title = "Physicochemical Factors Governing the Partition of Pramipexole and Its Five Impurities in Microemulsion Liquid Chromatographic Systems",
volume = "23",
number = "11",
pages = "2084-2092",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1681"
}

Vemić, A., Malenović, A., Rakić, T., Kostić, N. M., Jančić-Stojanović, B., Ivanović, D.,& Medenica, M.. (2012). Physicochemical Factors Governing the Partition of Pramipexole and Its Five Impurities in Microemulsion Liquid Chromatographic Systems. in Journal of the Brazilian Chemical Society
Soc Brasileira Quimica, Sao Paulo., 23(11), 2084-2092.
https://hdl.handle.net/21.15107/rcub_farfar_1681

Vemić A, Malenović A, Rakić T, Kostić NM, Jančić-Stojanović B, Ivanović D, Medenica M. Physicochemical Factors Governing the Partition of Pramipexole and Its Five Impurities in Microemulsion Liquid Chromatographic Systems. in Journal of the Brazilian Chemical Society. 2012;23(11):2084-2092.
https://hdl.handle.net/21.15107/rcub_farfar_1681 .

Vemić, Ana, Malenović, Anđelija, Rakić, Tijana, Kostić, Nada M., Jančić-Stojanović, Biljana, Ivanović, Darko, Medenica, Mirjana, "Physicochemical Factors Governing the Partition of Pramipexole and Its Five Impurities in Microemulsion Liquid Chromatographic Systems" in Journal of the Brazilian Chemical Society, 23, no. 11 (2012):2084-2092,
https://hdl.handle.net/21.15107/rcub_farfar_1681 .