TY  - CONF
AU  - Manić, Luka
AU  - Đorđević, Vladimir
AU  - Grubor, Nikica
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
AU  - Uysal-Onganer, Pinar
AU  - Mortoglou, Maria
AU  - Wallace, David
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5512
AB  - Istraživanje u oblasti karcinoma pankreasa i zagađivača iz životne sredine sve je intenzivnije. Za neke od ovih zagađivača pretpostavlja se da su povezani sa nastankom ili progresijom karcinoma pankreasa. Nijedna meta-analiza o povezanosti navedenog nije sprovedena, dok bi rezultati iste mogli pomoći u tumačenju dostupnih podataka i usmeravanju budućeg istraživanja. ...
AB  - There is a rise in research on the connection between pancreatic cancer and environmental pollutants. Some of these pollutants are assumed to be associated with the onset or progression of pancreatic cancer. No meta-analyses summarizing the association between these two have been conducted yet, while the results of such an analysis could help interpret current and guide future research.  ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?
T1  - A meta-analysis excerpt: Is exposure to environmental pollutants associated with pancreatic cancer?
SP  - 143
EP  - 146
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5512
ER  - 

@conference{
author = "Manić, Luka and Đorđević, Vladimir and Grubor, Nikica and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela and Uysal-Onganer, Pinar and Mortoglou, Maria and Wallace, David and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Istraživanje u oblasti karcinoma pankreasa i zagađivača iz životne sredine sve je intenzivnije. Za neke od ovih zagađivača pretpostavlja se da su povezani sa nastankom ili progresijom karcinoma pankreasa. Nijedna meta-analiza o povezanosti navedenog nije sprovedena, dok bi rezultati iste mogli pomoći u tumačenju dostupnih podataka i usmeravanju budućeg istraživanja. ..., There is a rise in research on the connection between pancreatic cancer and environmental pollutants. Some of these pollutants are assumed to be associated with the onset or progression of pancreatic cancer. No meta-analyses summarizing the association between these two have been conducted yet, while the results of such an analysis could help interpret current and guide future research.  ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?, A meta-analysis excerpt: Is exposure to environmental pollutants associated with pancreatic cancer?",
pages = "143-146",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5512"
}

Manić, L., Đorđević, V., Grubor, N., Bulat, Z., Antonijević, B., Đukić-Ćosić, D., Uysal-Onganer, P., Mortoglou, M., Wallace, D.,& Buha-Đorđević, A.. (2023). Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 143-146.
https://hdl.handle.net/21.15107/rcub_farfar_5512

Manić L, Đorđević V, Grubor N, Bulat Z, Antonijević B, Đukić-Ćosić D, Uysal-Onganer P, Mortoglou M, Wallace D, Buha-Đorđević A. Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:143-146.
https://hdl.handle.net/21.15107/rcub_farfar_5512 .

Manić, Luka, Đorđević, Vladimir, Grubor, Nikica, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, Uysal-Onganer, Pinar, Mortoglou, Maria, Wallace, David, Buha-Đorđević, Aleksandra, "Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):143-146,
https://hdl.handle.net/21.15107/rcub_farfar_5512 .

TY  - JOUR
AU  - Mortoglou, Maria
AU  - Manić, Luka
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Đorđević, Vladimir
AU  - Manis, Katherine
AU  - York, Lauren
AU  - Valle, Elizabeth
AU  - Wallace, David
AU  - Uysal-Onganer, Pinar
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4352
AB  - Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types with a limited overall survival rate due to the asymptomatic progression of symptoms in metastatic stages of the malignancy and the lack of an early reliable diagnostic biomarker. MicroRNAs (miRs/miRNAs) are small (~18–24 nucleotides), endogenous, non-coding RNAs, which are closely linked to the development of numerous malignancies comprising PDAC. Recent studies have described the role of environmental pollutants such as nickel (Ni) in PDAC, but the mechanisms of Ni-mediated toxicity in cancer are still not completely understood. Specifically, Ni has been found to alter the expression and function of miRs in several malignancies, leading to changes in target gene expression. In this study, we found that levels of Ni were significantly higher in cancerous tissue, thus implicating Ni in pancreatic carcinogenesis. Hence, in vitro studies followed by using both normal and pancreatic tumor cell lines and increasing Ni concentration increased lethality. Comparing LC50 values, Ni-acetate groups demonstrated lower values needed than in NiCl2 groups, suggesting greater Ni-acetate. Panc-10.05 cell line appeared the most sensitive to Ni compounds. Exposure to Ni-acetate resulted in an increased phospho-AKT, and decreased FOXO1 expression in Panc-10.05 cells, while NiCl2 also increased PTEN expression in Panc-10.05 cells. Specifically, following NiCl2 exposure to PDAC cells, the expression levels of miR-221 and miR-155 were significantly upregulated, while the expression levels of miR-126 were significantly decreased. Hence, our study has suggested pilot insights to indicate that the environmental pollutant Ni plays an important role in the progression of PDAC by promoting an association between miRs and Ni exposure during PDAC pathogenesis.
PB  - MDPI
T2  - Toxics
T1  - Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs
VL  - 10
IS  - 3
DO  - 10.3390/toxics10030148
ER  - 

@article{
author = "Mortoglou, Maria and Manić, Luka and Buha-Đorđević, Aleksandra and Bulat, Zorica and Đorđević, Vladimir and Manis, Katherine and York, Lauren and Valle, Elizabeth and Wallace, David and Uysal-Onganer, Pinar",
year = "2022",
abstract = "Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types with a limited overall survival rate due to the asymptomatic progression of symptoms in metastatic stages of the malignancy and the lack of an early reliable diagnostic biomarker. MicroRNAs (miRs/miRNAs) are small (~18–24 nucleotides), endogenous, non-coding RNAs, which are closely linked to the development of numerous malignancies comprising PDAC. Recent studies have described the role of environmental pollutants such as nickel (Ni) in PDAC, but the mechanisms of Ni-mediated toxicity in cancer are still not completely understood. Specifically, Ni has been found to alter the expression and function of miRs in several malignancies, leading to changes in target gene expression. In this study, we found that levels of Ni were significantly higher in cancerous tissue, thus implicating Ni in pancreatic carcinogenesis. Hence, in vitro studies followed by using both normal and pancreatic tumor cell lines and increasing Ni concentration increased lethality. Comparing LC50 values, Ni-acetate groups demonstrated lower values needed than in NiCl2 groups, suggesting greater Ni-acetate. Panc-10.05 cell line appeared the most sensitive to Ni compounds. Exposure to Ni-acetate resulted in an increased phospho-AKT, and decreased FOXO1 expression in Panc-10.05 cells, while NiCl2 also increased PTEN expression in Panc-10.05 cells. Specifically, following NiCl2 exposure to PDAC cells, the expression levels of miR-221 and miR-155 were significantly upregulated, while the expression levels of miR-126 were significantly decreased. Hence, our study has suggested pilot insights to indicate that the environmental pollutant Ni plays an important role in the progression of PDAC by promoting an association between miRs and Ni exposure during PDAC pathogenesis.",
publisher = "MDPI",
journal = "Toxics",
title = "Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs",
volume = "10",
number = "3",
doi = "10.3390/toxics10030148"
}

Mortoglou, M., Manić, L., Buha-Đorđević, A., Bulat, Z., Đorđević, V., Manis, K., York, L., Valle, E., Wallace, D.,& Uysal-Onganer, P.. (2022). Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs. in Toxics
MDPI., 10(3).
https://doi.org/10.3390/toxics10030148

Mortoglou M, Manić L, Buha-Đorđević A, Bulat Z, Đorđević V, Manis K, York L, Valle E, Wallace D, Uysal-Onganer P. Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs. in Toxics. 2022;10(3).
doi:10.3390/toxics10030148 .

Mortoglou, Maria, Manić, Luka, Buha-Đorđević, Aleksandra, Bulat, Zorica, Đorđević, Vladimir, Manis, Katherine, York, Lauren, Valle, Elizabeth, Wallace, David, Uysal-Onganer, Pinar, "Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs" in Toxics, 10, no. 3 (2022),
https://doi.org/10.3390/toxics10030148 . .

TY  - JOUR
AU  - Đukić-Ćosić, Danijela
AU  - Baralić, Katarina
AU  - Javorac, Dragana
AU  - Bulat, Zorica
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Đorđević, Vladimir
AU  - Repić, Aleksandra
AU  - Buha-Đorđević, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4277
AB  - The major goal of this study was to estimate the correlations and dose-response pattern between the measured blood toxic metals (cadmium (Cd), mercury (Hg), chromium (Cr), nickel (Ni))/metalloid (arsenic (As)) and serum insulin level by conducting Benchmark dose (BMD) analysis of human data. The study involved 435 non-occupationally exposed individuals (217 men and 218 women). The samples were collected at health care institutions in Belgrade, Serbia, from January 2019 to May 2021. Blood sample preparation was conducted by microwave digestion. Cd was measured by graphite furnace atomic absorption spectrophotometry (GF-AAS), while inductively coupled plasma-mass spectrometry (ICP-MS) was used to measure Hg, Ni, Cr and As. BMD analysis of insulin levels represented as quantal data was done using the PROAST software version 70.1 (model averaging methodology, BMD response: 10%). In the male population, there was no correlation between toxic metal/metalloid concentrations and insulin level. However, in the female population/whole population, a high positive correlation for As and Hg, and a strong negative correlation for Ni and measured serum insulin level was established. BMD modelling revealed quantitative associations between blood toxic metal/metalloid concentrations and serum insulin levels. All the estimated BMD intervals were wide except the one for As, reflecting a high degree of confidence in the estimations and possible role of As as a metabolic disruptor. These results indicate that, in the case of As blood concentrations, even values higher than BMD (BMDL): 3.27 (1.26) (male population), 2.79 (0.771) (female population), or 1.18 (2.96) μg/L (whole population) might contribute to a 10% higher risk of insulin level alterations, meaning 10% higher risk of blood insulin increasing from within reference range to above reference range. The obtained results contribute to the current body of knowledge on the use of BMD modelling for analysing human data.
PB  - Elsevier Inc
T2  - Environmental Research
T1  - Exploring the relationship between blood toxic metal(oid)s and serum insulin levels through benchmark modelling of human data: Possible role of arsenic as a metabolic disruptor
VL  - 215
DO  - 10.1016/j.envres.2022.114283
ER  - 

@article{
author = "Đukić-Ćosić, Danijela and Baralić, Katarina and Javorac, Dragana and Bulat, Zorica and Ćurčić, Marijana and Antonijević, Biljana and Đorđević, Vladimir and Repić, Aleksandra and Buha-Đorđević, Aleksandra",
year = "2022",
abstract = "The major goal of this study was to estimate the correlations and dose-response pattern between the measured blood toxic metals (cadmium (Cd), mercury (Hg), chromium (Cr), nickel (Ni))/metalloid (arsenic (As)) and serum insulin level by conducting Benchmark dose (BMD) analysis of human data. The study involved 435 non-occupationally exposed individuals (217 men and 218 women). The samples were collected at health care institutions in Belgrade, Serbia, from January 2019 to May 2021. Blood sample preparation was conducted by microwave digestion. Cd was measured by graphite furnace atomic absorption spectrophotometry (GF-AAS), while inductively coupled plasma-mass spectrometry (ICP-MS) was used to measure Hg, Ni, Cr and As. BMD analysis of insulin levels represented as quantal data was done using the PROAST software version 70.1 (model averaging methodology, BMD response: 10%). In the male population, there was no correlation between toxic metal/metalloid concentrations and insulin level. However, in the female population/whole population, a high positive correlation for As and Hg, and a strong negative correlation for Ni and measured serum insulin level was established. BMD modelling revealed quantitative associations between blood toxic metal/metalloid concentrations and serum insulin levels. All the estimated BMD intervals were wide except the one for As, reflecting a high degree of confidence in the estimations and possible role of As as a metabolic disruptor. These results indicate that, in the case of As blood concentrations, even values higher than BMD (BMDL): 3.27 (1.26) (male population), 2.79 (0.771) (female population), or 1.18 (2.96) μg/L (whole population) might contribute to a 10% higher risk of insulin level alterations, meaning 10% higher risk of blood insulin increasing from within reference range to above reference range. The obtained results contribute to the current body of knowledge on the use of BMD modelling for analysing human data.",
publisher = "Elsevier Inc",
journal = "Environmental Research",
title = "Exploring the relationship between blood toxic metal(oid)s and serum insulin levels through benchmark modelling of human data: Possible role of arsenic as a metabolic disruptor",
volume = "215",
doi = "10.1016/j.envres.2022.114283"
}

Đukić-Ćosić, D., Baralić, K., Javorac, D., Bulat, Z., Ćurčić, M., Antonijević, B., Đorđević, V., Repić, A.,& Buha-Đorđević, A.. (2022). Exploring the relationship between blood toxic metal(oid)s and serum insulin levels through benchmark modelling of human data: Possible role of arsenic as a metabolic disruptor. in Environmental Research
Elsevier Inc., 215.
https://doi.org/10.1016/j.envres.2022.114283

Đukić-Ćosić D, Baralić K, Javorac D, Bulat Z, Ćurčić M, Antonijević B, Đorđević V, Repić A, Buha-Đorđević A. Exploring the relationship between blood toxic metal(oid)s and serum insulin levels through benchmark modelling of human data: Possible role of arsenic as a metabolic disruptor. in Environmental Research. 2022;215.
doi:10.1016/j.envres.2022.114283 .

Đukić-Ćosić, Danijela, Baralić, Katarina, Javorac, Dragana, Bulat, Zorica, Ćurčić, Marijana, Antonijević, Biljana, Đorđević, Vladimir, Repić, Aleksandra, Buha-Đorđević, Aleksandra, "Exploring the relationship between blood toxic metal(oid)s and serum insulin levels through benchmark modelling of human data: Possible role of arsenic as a metabolic disruptor" in Environmental Research, 215 (2022),
https://doi.org/10.1016/j.envres.2022.114283 . .

TY  - CONF
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Javorac, Dragana
AU  - Mandić-Rajčević, Stefan
AU  - Đorđević, Vladimir
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Buha-Đorđević, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4353
PB  - Elsevier B.V.
C3  - Toxicology Letters
T1  - Arsenic - effect on insulin level in the general population of Serbia
VL  - 368
IS  - Supplement
SP  - S276
EP  - S276
DO  - 10.1016/j.toxlet.2022.07.730
ER  - 

@conference{
author = "Marić, Đurđica and Baralić, Katarina and Javorac, Dragana and Mandić-Rajčević, Stefan and Đorđević, Vladimir and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Bulat, Zorica and Buha-Đorđević, Aleksandra",
year = "2022",
publisher = "Elsevier B.V.",
journal = "Toxicology Letters",
title = "Arsenic - effect on insulin level in the general population of Serbia",
volume = "368",
number = "Supplement",
pages = "S276-S276",
doi = "10.1016/j.toxlet.2022.07.730"
}

Marić, Đ., Baralić, K., Javorac, D., Mandić-Rajčević, S., Đorđević, V., Đukić-Ćosić, D., Ćurčić, M., Bulat, Z.,& Buha-Đorđević, A.. (2022). Arsenic - effect on insulin level in the general population of Serbia. in Toxicology Letters
Elsevier B.V.., 368(Supplement), S276-S276.
https://doi.org/10.1016/j.toxlet.2022.07.730

Marić Đ, Baralić K, Javorac D, Mandić-Rajčević S, Đorđević V, Đukić-Ćosić D, Ćurčić M, Bulat Z, Buha-Đorđević A. Arsenic - effect on insulin level in the general population of Serbia. in Toxicology Letters. 2022;368(Supplement):S276-S276.
doi:10.1016/j.toxlet.2022.07.730 .

Marić, Đurđica, Baralić, Katarina, Javorac, Dragana, Mandić-Rajčević, Stefan, Đorđević, Vladimir, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Bulat, Zorica, Buha-Đorđević, Aleksandra, "Arsenic - effect on insulin level in the general population of Serbia" in Toxicology Letters, 368, no. Supplement (2022):S276-S276,
https://doi.org/10.1016/j.toxlet.2022.07.730 . .

TY  - JOUR
AU  - Wallace, David
AU  - Spandidos, Demetrios A.
AU  - Tsatsakis, Aristidis
AU  - Schweitzer, Amie
AU  - Đorđević, Vladimir
AU  - Buha-Đorđević, Aleksandra
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3265
AB  - Pancreatic cancer (PC) is insidious with a high mortality rate due to the lack of symptomology prior to diagnosis. Mitochondrial involvement in PC development is becoming accepted, and exposure to cadmium (Cd) is suspected of being a risk factor for the development of PC; however, the mechanisms involved remain unclear. In this study, we examined the role of Cd as a mitochondrial toxicant and whether alterations in mitochondrial function may be an underlying cause for the development of PC. In this study, cadmium chloride (CdCl2)-mediated toxicity in hTERT-HPNE and AsPC-1 pancreatic cell lines was determined by MTT assay. We also investigated the release of LDH and the generation of free radicals. Mitochondrial toxicity assays were performed in media containing glucose (25 mM) or galactose (10 mM) and following exposure to CdCl2 (0-100 M) followed by MTT assay. For the confirmation of mitochondrial toxicity, we measured the release of ATP following exposure to CdCl2. Initial experiments confirmed that exposure to CdCl2 did not reduce the viability of either cell line until a concentration of >10 M was used. Non-linear analysis of the response curves revealed lethal concentration 50% (LC50) values for CdCl2 in the HPNE cells of 77 M compared to 42 M in the AsPC-1 cells (P lt 0.01). The CdCl2-mediated mitochondrial toxic effects were greater in the HPNE cells, suggesting a heightened sensitivity to the effects of CdCl2, not due to elevated oxidative stress. Increased mitochondrial toxic sensitivity was indicated by a 73.4% reduction in IC50 values in the HPNE cells cultured in galactose compared to culture in glucose media, whereas the AsPC-1 cells exhibited a 58.8% reduction in IC50 values. In addition, the higher concentration of CdCl2 elicited a significant cell-dependent effect on ATP release in both cell lines, suggestive of CdCl2 being a mitochondrial toxicant. Cell survival was unaffected following exposure to low concentrations of CdCl2; however, exposure did alter mitochondrial function (control cells > tumor cells). Therefore, the findings of this study indicate that the mitochondria may be a site of action for cadmium in promoting tumor development.
PB  - Spandidos Publ Ltd, Athens
T2  - International Journal of Molecular Medicine
T1  - Potential interaction of cadmium chloride with pancreatic mitochondria: Implications for pancreatic cancer
VL  - 44
IS  - 1
SP  - 145
EP  - 156
DO  - 10.3892/ijmm.2019.4204
ER  - 

@article{
author = "Wallace, David and Spandidos, Demetrios A. and Tsatsakis, Aristidis and Schweitzer, Amie and Đorđević, Vladimir and Buha-Đorđević, Aleksandra",
year = "2019",
abstract = "Pancreatic cancer (PC) is insidious with a high mortality rate due to the lack of symptomology prior to diagnosis. Mitochondrial involvement in PC development is becoming accepted, and exposure to cadmium (Cd) is suspected of being a risk factor for the development of PC; however, the mechanisms involved remain unclear. In this study, we examined the role of Cd as a mitochondrial toxicant and whether alterations in mitochondrial function may be an underlying cause for the development of PC. In this study, cadmium chloride (CdCl2)-mediated toxicity in hTERT-HPNE and AsPC-1 pancreatic cell lines was determined by MTT assay. We also investigated the release of LDH and the generation of free radicals. Mitochondrial toxicity assays were performed in media containing glucose (25 mM) or galactose (10 mM) and following exposure to CdCl2 (0-100 M) followed by MTT assay. For the confirmation of mitochondrial toxicity, we measured the release of ATP following exposure to CdCl2. Initial experiments confirmed that exposure to CdCl2 did not reduce the viability of either cell line until a concentration of >10 M was used. Non-linear analysis of the response curves revealed lethal concentration 50% (LC50) values for CdCl2 in the HPNE cells of 77 M compared to 42 M in the AsPC-1 cells (P lt 0.01). The CdCl2-mediated mitochondrial toxic effects were greater in the HPNE cells, suggesting a heightened sensitivity to the effects of CdCl2, not due to elevated oxidative stress. Increased mitochondrial toxic sensitivity was indicated by a 73.4% reduction in IC50 values in the HPNE cells cultured in galactose compared to culture in glucose media, whereas the AsPC-1 cells exhibited a 58.8% reduction in IC50 values. In addition, the higher concentration of CdCl2 elicited a significant cell-dependent effect on ATP release in both cell lines, suggestive of CdCl2 being a mitochondrial toxicant. Cell survival was unaffected following exposure to low concentrations of CdCl2; however, exposure did alter mitochondrial function (control cells > tumor cells). Therefore, the findings of this study indicate that the mitochondria may be a site of action for cadmium in promoting tumor development.",
publisher = "Spandidos Publ Ltd, Athens",
journal = "International Journal of Molecular Medicine",
title = "Potential interaction of cadmium chloride with pancreatic mitochondria: Implications for pancreatic cancer",
volume = "44",
number = "1",
pages = "145-156",
doi = "10.3892/ijmm.2019.4204"
}

Wallace, D., Spandidos, D. A., Tsatsakis, A., Schweitzer, A., Đorđević, V.,& Buha-Đorđević, A.. (2019). Potential interaction of cadmium chloride with pancreatic mitochondria: Implications for pancreatic cancer. in International Journal of Molecular Medicine
Spandidos Publ Ltd, Athens., 44(1), 145-156.
https://doi.org/10.3892/ijmm.2019.4204

Wallace D, Spandidos DA, Tsatsakis A, Schweitzer A, Đorđević V, Buha-Đorđević A. Potential interaction of cadmium chloride with pancreatic mitochondria: Implications for pancreatic cancer. in International Journal of Molecular Medicine. 2019;44(1):145-156.
doi:10.3892/ijmm.2019.4204 .

Wallace, David, Spandidos, Demetrios A., Tsatsakis, Aristidis, Schweitzer, Amie, Đorđević, Vladimir, Buha-Đorđević, Aleksandra, "Potential interaction of cadmium chloride with pancreatic mitochondria: Implications for pancreatic cancer" in International Journal of Molecular Medicine, 44, no. 1 (2019):145-156,
https://doi.org/10.3892/ijmm.2019.4204 . .

TY  - JOUR
AU  - Đorđević, Vladimir
AU  - Wallace, David
AU  - Schweitzer, Amie
AU  - Boricić, Novica
AU  - Knežević, Đorđe
AU  - Matić, Slavko
AU  - Grubor, Nikola
AU  - Kerkez, Mirko
AU  - Radenković, Dejan
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Matović, Vesna
AU  - Buha, Aleksandra
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3346
AB  - Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd) body burden. Hence, the aim of this study was to investigate the role of this environmental pollutant in PC development by conducting human observational, experimental and in vitro studies. The case-control study included 31 patients with a histologically based diagnosis of exocrine PC subjected to radical surgical intervention as cases and 29 accidental fatalities or subjects who died of a nonmalignant illness as controls. Animal study included two treated groups of Wistar rats (15 and 30 mg Cd/kg b.w) and untreated control group, sacrificed 24 h after single oral exposure. In in vitro study pancreas hTERT-HPNE and AsPC-1 cells were exposed to different Cd concentrations corresponding to levels measured in human cancerous pancreatic tissue. Cd content in cancer tissue significantly differed from the content in healthy controls. Odds ratio levels for PC development were 2.79 (95% CI 0.91-8.50) and 3.44 (95% CI 1.19-9.95) in the third and fourth quartiles of Cd distribution, respectively. Animal study confirmed Cd deposition in pancreatic tissue. In vitro studies revealed that Cd produces disturbances in intrinsic pathway of apoptotic activity and the elevation in oxidative stress in pancreatic cells. This study presents three different lines of evidence pointing towards Cd as an agent responsible for the development of PC.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Environment International
T1  - Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies
VL  - 128
SP  - 353
EP  - 361
DO  - 10.1016/j.envint.2019.04.048
ER  - 

@article{
author = "Đorđević, Vladimir and Wallace, David and Schweitzer, Amie and Boricić, Novica and Knežević, Đorđe and Matić, Slavko and Grubor, Nikola and Kerkez, Mirko and Radenković, Dejan and Bulat, Zorica and Antonijević, Biljana and Matović, Vesna and Buha, Aleksandra",
year = "2019",
abstract = "Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd) body burden. Hence, the aim of this study was to investigate the role of this environmental pollutant in PC development by conducting human observational, experimental and in vitro studies. The case-control study included 31 patients with a histologically based diagnosis of exocrine PC subjected to radical surgical intervention as cases and 29 accidental fatalities or subjects who died of a nonmalignant illness as controls. Animal study included two treated groups of Wistar rats (15 and 30 mg Cd/kg b.w) and untreated control group, sacrificed 24 h after single oral exposure. In in vitro study pancreas hTERT-HPNE and AsPC-1 cells were exposed to different Cd concentrations corresponding to levels measured in human cancerous pancreatic tissue. Cd content in cancer tissue significantly differed from the content in healthy controls. Odds ratio levels for PC development were 2.79 (95% CI 0.91-8.50) and 3.44 (95% CI 1.19-9.95) in the third and fourth quartiles of Cd distribution, respectively. Animal study confirmed Cd deposition in pancreatic tissue. In vitro studies revealed that Cd produces disturbances in intrinsic pathway of apoptotic activity and the elevation in oxidative stress in pancreatic cells. This study presents three different lines of evidence pointing towards Cd as an agent responsible for the development of PC.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Environment International",
title = "Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies",
volume = "128",
pages = "353-361",
doi = "10.1016/j.envint.2019.04.048"
}

Đorđević, V., Wallace, D., Schweitzer, A., Boricić, N., Knežević, Đ., Matić, S., Grubor, N., Kerkez, M., Radenković, D., Bulat, Z., Antonijević, B., Matović, V.,& Buha, A.. (2019). Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies. in Environment International
Pergamon-Elsevier Science Ltd, Oxford., 128, 353-361.
https://doi.org/10.1016/j.envint.2019.04.048

Đorđević V, Wallace D, Schweitzer A, Boricić N, Knežević Đ, Matić S, Grubor N, Kerkez M, Radenković D, Bulat Z, Antonijević B, Matović V, Buha A. Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies. in Environment International. 2019;128:353-361.
doi:10.1016/j.envint.2019.04.048 .

Đorđević, Vladimir, Wallace, David, Schweitzer, Amie, Boricić, Novica, Knežević, Đorđe, Matić, Slavko, Grubor, Nikola, Kerkez, Mirko, Radenković, Dejan, Bulat, Zorica, Antonijević, Biljana, Matović, Vesna, Buha, Aleksandra, "Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies" in Environment International, 128 (2019):353-361,
https://doi.org/10.1016/j.envint.2019.04.048 . .

TY  - JOUR
AU  - Buha, Aleksandra
AU  - Wallace, David
AU  - Matović, Vesna
AU  - Schweitzer, Amie
AU  - Oluić, Branislav
AU  - Micić, Dušan
AU  - Đorđević, Vladimir
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2836
AB  - Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scant. Exposure to cadmium (Cd), a ubiquitous metal associated with well-established toxic and carcinogenic properties, has been hypothesized to one putative cause of PC. Hence, we analyzed recently published observational studies, meta-analyses, and experimental animal and in vitro studies with the aim of summarizing the evidence of Cd involvement in PC development and describing the possible mechanisms. Consolidation of epidemiological data on PC and exposure to Cd indicated a significant association with an elevated risk of PC among general population exposed to Cd. Cadmium exposure of laboratory animals was showed to cause PC supporting the findings suggested by human studies. The concordance with human and animal studies is buttressed by in vitro studies, although in vitro data interpretation is problematic. In most instances, only significant effects are reported, and the concentrations of Cd are excessive, which would skew interpretation. Previous reports suggest that oxidative stress, apoptotic changes, and DNA cross-linking and hypermethylation are involved in Cd-mediated carcinogenesis. Undoubtedly, a significant amount of work is still needed to achieve a better understanding of the Cd involvement in pancreatic cancer which could facilitate prevention, diagnosis, and therapy of this fatal disease.
PB  - Hindawi Ltd, London
T2  - Biomed Research International
T1  - Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence
DO  - 10.1155/2017/1981837
ER  - 

@article{
author = "Buha, Aleksandra and Wallace, David and Matović, Vesna and Schweitzer, Amie and Oluić, Branislav and Micić, Dušan and Đorđević, Vladimir",
year = "2017",
abstract = "Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scant. Exposure to cadmium (Cd), a ubiquitous metal associated with well-established toxic and carcinogenic properties, has been hypothesized to one putative cause of PC. Hence, we analyzed recently published observational studies, meta-analyses, and experimental animal and in vitro studies with the aim of summarizing the evidence of Cd involvement in PC development and describing the possible mechanisms. Consolidation of epidemiological data on PC and exposure to Cd indicated a significant association with an elevated risk of PC among general population exposed to Cd. Cadmium exposure of laboratory animals was showed to cause PC supporting the findings suggested by human studies. The concordance with human and animal studies is buttressed by in vitro studies, although in vitro data interpretation is problematic. In most instances, only significant effects are reported, and the concentrations of Cd are excessive, which would skew interpretation. Previous reports suggest that oxidative stress, apoptotic changes, and DNA cross-linking and hypermethylation are involved in Cd-mediated carcinogenesis. Undoubtedly, a significant amount of work is still needed to achieve a better understanding of the Cd involvement in pancreatic cancer which could facilitate prevention, diagnosis, and therapy of this fatal disease.",
publisher = "Hindawi Ltd, London",
journal = "Biomed Research International",
title = "Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence",
doi = "10.1155/2017/1981837"
}

Buha, A., Wallace, D., Matović, V., Schweitzer, A., Oluić, B., Micić, D.,& Đorđević, V.. (2017). Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence. in Biomed Research International
Hindawi Ltd, London..
https://doi.org/10.1155/2017/1981837

Buha A, Wallace D, Matović V, Schweitzer A, Oluić B, Micić D, Đorđević V. Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence. in Biomed Research International. 2017;.
doi:10.1155/2017/1981837 .

Buha, Aleksandra, Wallace, David, Matović, Vesna, Schweitzer, Amie, Oluić, Branislav, Micić, Dušan, Đorđević, Vladimir, "Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence" in Biomed Research International (2017),
https://doi.org/10.1155/2017/1981837 . .

TY  - JOUR
AU  - Đorđević, Vladimir
AU  - Buha, Aleksandra
AU  - Radojković, Željko
AU  - Zarić, Nemanja
AU  - Ostojić, Slavenko
AU  - Lekić, Nebojša
AU  - Ninić, Aleksandar
AU  - Ćulafić, Milica
AU  - Mihaljević, Biljana
AU  - Antić, Darko
AU  - Vuković, Vojin
AU  - Kerkez, Mirko
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2556
AB  - Following solid organ transplantation, the patient's management includes the provision of immunosuppressive therapy to the recipient. All kidney transplant recipients require lifelong immunosuppression. Regardless the improving survival following solid organ transplantation, post-transplant complications such as the development of malignancy due to immunosuppression remain to be an issue. One of the most common malignancies encountered in the post-solid organ transplant is lymphoproliferative disorder likely developed as a consequence of immunosuppression. We report a case of plasma cell type lymphoma in the ileocecal region of a 45-year-old male kidney transplant patient who was on a tacrolimus-based regimen for ten years. Although literature data indicate differently localized lymphoma as an adverse reaction to the long term use of tacrolimus, to our knowledge, this is the first described case of lymphoma in the ileocecal region. Serious adverse drug reactions and potential toxicity of tacrolimus emphasize the importance of finding the optimal balance between effective drug concentration and the risk associated with its use.
AB  - Nakon transplantacije organa, pacijenti primaoci organa se stavljaju na režim imunosupresivne terapije, a u primalaca bubrega ta terapija je doživotna. Bez obzira na poboljšanje preživljavanja nakon transplantacije organa, brojne su komplikacije koje se mogu javiti nakon transplantacije, a razvoj maligniteta usled imunosupresije nastavlja da bude značajan problem. Jedan od najčešćih tipova maligniteta koji se sreće kod ovakvih pacijenata je limfoproliferativni poremećaj koji se verovatno razvija kao posledica pomenute imunosupresije. Opisan je slučaj limfoma u ileocekalnoj regiji u 45-godišnjeg muškarca sa transplantiranim bubregom, koji je bio na imunosupresivnoj terapiji zasnovanoj na takrolimusu, tokom 10 godina. Literaturni podaci ukazuju na drugačiju lokalizaciju limfoma kao neželjene reakcije nakon dugoročnog korišćenja takrolimusa, pa je prema našim saznanjima, ovo jedinstven slučaj razvoja limfoma u ileocekalnoj regiji. Ozbiljne neželjene reakcije i toksični potencijal takrolimusa naglašavaju značaj pronalaženja optimalnog balansa između efektivne koncentracije leka i rizika vezanih za njegovu upotrebu.
PB  - Most Art doo, Beograd
T2  - MD - Medical data
T1  - Development of Hodgkin lymphoma in the ileocecal region in kidney transplant patient on long term immunosuppressive therapy: A case report
T1  - Razvoj Hodžkinovog limfoma u ileocekalnoj regiji pacijenta sa transplantiranim bubregom na dugoročnoj imunosupresivnoj terapiji - prikaz slučaja
VL  - 8
IS  - 4
SP  - 265
EP  - 269
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2556
ER  - 

@article{
author = "Đorđević, Vladimir and Buha, Aleksandra and Radojković, Željko and Zarić, Nemanja and Ostojić, Slavenko and Lekić, Nebojša and Ninić, Aleksandar and Ćulafić, Milica and Mihaljević, Biljana and Antić, Darko and Vuković, Vojin and Kerkez, Mirko",
year = "2016",
abstract = "Following solid organ transplantation, the patient's management includes the provision of immunosuppressive therapy to the recipient. All kidney transplant recipients require lifelong immunosuppression. Regardless the improving survival following solid organ transplantation, post-transplant complications such as the development of malignancy due to immunosuppression remain to be an issue. One of the most common malignancies encountered in the post-solid organ transplant is lymphoproliferative disorder likely developed as a consequence of immunosuppression. We report a case of plasma cell type lymphoma in the ileocecal region of a 45-year-old male kidney transplant patient who was on a tacrolimus-based regimen for ten years. Although literature data indicate differently localized lymphoma as an adverse reaction to the long term use of tacrolimus, to our knowledge, this is the first described case of lymphoma in the ileocecal region. Serious adverse drug reactions and potential toxicity of tacrolimus emphasize the importance of finding the optimal balance between effective drug concentration and the risk associated with its use., Nakon transplantacije organa, pacijenti primaoci organa se stavljaju na režim imunosupresivne terapije, a u primalaca bubrega ta terapija je doživotna. Bez obzira na poboljšanje preživljavanja nakon transplantacije organa, brojne su komplikacije koje se mogu javiti nakon transplantacije, a razvoj maligniteta usled imunosupresije nastavlja da bude značajan problem. Jedan od najčešćih tipova maligniteta koji se sreće kod ovakvih pacijenata je limfoproliferativni poremećaj koji se verovatno razvija kao posledica pomenute imunosupresije. Opisan je slučaj limfoma u ileocekalnoj regiji u 45-godišnjeg muškarca sa transplantiranim bubregom, koji je bio na imunosupresivnoj terapiji zasnovanoj na takrolimusu, tokom 10 godina. Literaturni podaci ukazuju na drugačiju lokalizaciju limfoma kao neželjene reakcije nakon dugoročnog korišćenja takrolimusa, pa je prema našim saznanjima, ovo jedinstven slučaj razvoja limfoma u ileocekalnoj regiji. Ozbiljne neželjene reakcije i toksični potencijal takrolimusa naglašavaju značaj pronalaženja optimalnog balansa između efektivne koncentracije leka i rizika vezanih za njegovu upotrebu.",
publisher = "Most Art doo, Beograd",
journal = "MD - Medical data",
title = "Development of Hodgkin lymphoma in the ileocecal region in kidney transplant patient on long term immunosuppressive therapy: A case report, Razvoj Hodžkinovog limfoma u ileocekalnoj regiji pacijenta sa transplantiranim bubregom na dugoročnoj imunosupresivnoj terapiji - prikaz slučaja",
volume = "8",
number = "4",
pages = "265-269",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2556"
}

Đorđević, V., Buha, A., Radojković, Ž., Zarić, N., Ostojić, S., Lekić, N., Ninić, A., Ćulafić, M., Mihaljević, B., Antić, D., Vuković, V.,& Kerkez, M.. (2016). Development of Hodgkin lymphoma in the ileocecal region in kidney transplant patient on long term immunosuppressive therapy: A case report. in MD - Medical data
Most Art doo, Beograd., 8(4), 265-269.
https://hdl.handle.net/21.15107/rcub_farfar_2556

Đorđević V, Buha A, Radojković Ž, Zarić N, Ostojić S, Lekić N, Ninić A, Ćulafić M, Mihaljević B, Antić D, Vuković V, Kerkez M. Development of Hodgkin lymphoma in the ileocecal region in kidney transplant patient on long term immunosuppressive therapy: A case report. in MD - Medical data. 2016;8(4):265-269.
https://hdl.handle.net/21.15107/rcub_farfar_2556 .

Đorđević, Vladimir, Buha, Aleksandra, Radojković, Željko, Zarić, Nemanja, Ostojić, Slavenko, Lekić, Nebojša, Ninić, Aleksandar, Ćulafić, Milica, Mihaljević, Biljana, Antić, Darko, Vuković, Vojin, Kerkez, Mirko, "Development of Hodgkin lymphoma in the ileocecal region in kidney transplant patient on long term immunosuppressive therapy: A case report" in MD - Medical data, 8, no. 4 (2016):265-269,
https://hdl.handle.net/21.15107/rcub_farfar_2556 .

TY  - CONF
AU  - Đorđević, Vladimir
AU  - Knežević, D.
AU  - Matić, S.
AU  - Kerkez, Mirko
AU  - Zarić, N.
AU  - Grubor, Nikica
AU  - Bidzić, N.
AU  - Boricić, Novica
AU  - Boricić, I.
AU  - Matović, Vesna
AU  - Buha, Aleksandra
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2666
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Cadmium in human pancreatic cancer - preliminary report
VL  - 258
IS  - Supplement
SP  - S92
EP  - S93
DO  - 10.1016/j.toxlet.2016.06.1406
ER  - 

@conference{
author = "Đorđević, Vladimir and Knežević, D. and Matić, S. and Kerkez, Mirko and Zarić, N. and Grubor, Nikica and Bidzić, N. and Boricić, Novica and Boricić, I. and Matović, Vesna and Buha, Aleksandra",
year = "2016",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Cadmium in human pancreatic cancer - preliminary report",
volume = "258",
number = "Supplement",
pages = "S92-S93",
doi = "10.1016/j.toxlet.2016.06.1406"
}

Đorđević, V., Knežević, D., Matić, S., Kerkez, M., Zarić, N., Grubor, N., Bidzić, N., Boricić, N., Boricić, I., Matović, V.,& Buha, A.. (2016). Cadmium in human pancreatic cancer - preliminary report. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 258(Supplement), S92-S93.
https://doi.org/10.1016/j.toxlet.2016.06.1406

Đorđević V, Knežević D, Matić S, Kerkez M, Zarić N, Grubor N, Bidzić N, Boricić N, Boricić I, Matović V, Buha A. Cadmium in human pancreatic cancer - preliminary report. in Toxicology Letters. 2016;258(Supplement):S92-S93.
doi:10.1016/j.toxlet.2016.06.1406 .

Đorđević, Vladimir, Knežević, D., Matić, S., Kerkez, Mirko, Zarić, N., Grubor, Nikica, Bidzić, N., Boricić, Novica, Boricić, I., Matović, Vesna, Buha, Aleksandra, "Cadmium in human pancreatic cancer - preliminary report" in Toxicology Letters, 258, no. Supplement (2016):S92-S93,
https://doi.org/10.1016/j.toxlet.2016.06.1406 . .

TY  - JOUR
AU  - Đuričić, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Miljković, Milica
AU  - Kerkez, Mirko
AU  - Đorđević, Vladimir
AU  - Đurasić, Ljubomir
AU  - Šobajić, Slađana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2431
AB  - Background: This study investigated the effects of a nutritionally relevant intake of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids derived from oily fish or a fish oil supplement on selected cardiovascular risk factors in average middle-aged individuals. Methods: Thirty-three participants were randomized to receive salmon (oily fish) providing 274 mg EPA + 671 mg DHA/day or a commercial fish oil supplement providing 396 mg EPA + 250 mg DHA/day in a cross-over trial over an 8-week period separated by a 6-month washout period. Blood samples were collected before and after each intervention and lipids, inflammatory and oxidative stress parameters were determined. Results: Plasma levels of EPA, DHA and total n-3 fatty acids significantly increased after both interventions. A decreasing trend in triglycerides was more pronounced with salmon than with the fish oil supplement, but the changes noticed were not significant. Although there were no relevant changes in inflammatory marker concentrations at the end of both interventions, significant negative correlations were noticed between total plasma n-3 fatty acids and soluble intercellular adhesion molecule and C-reactive protein throughout the whole intervention period (p  lt  0.05). Among the oxidative stress parameters, intervention with salmon showed a prooxidative effect through a superoxide anion increase (p = 0.025). A relevant positive correlation was also found between its concentration and total plasma n-3 fatty acids (p  lt  0.05). Other oxidative stress markers were not significantly influenced by the dietary interventions applied. Conclusions: Following two sets of recommendations for n-3 fatty acids intake aimed at the general public had only a moderate effect on the selected cardiovascular risk factors in average healthy middle-aged subjects over a short-term period.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population
VL  - 34
IS  - 3
SP  - 304
EP  - 313
DO  - 10.2478/jomb-2014-0039
ER  - 

@article{
author = "Đuričić, Ivana and Kotur-Stevuljević, Jelena and Miljković, Milica and Kerkez, Mirko and Đorđević, Vladimir and Đurasić, Ljubomir and Šobajić, Slađana",
year = "2015",
abstract = "Background: This study investigated the effects of a nutritionally relevant intake of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids derived from oily fish or a fish oil supplement on selected cardiovascular risk factors in average middle-aged individuals. Methods: Thirty-three participants were randomized to receive salmon (oily fish) providing 274 mg EPA + 671 mg DHA/day or a commercial fish oil supplement providing 396 mg EPA + 250 mg DHA/day in a cross-over trial over an 8-week period separated by a 6-month washout period. Blood samples were collected before and after each intervention and lipids, inflammatory and oxidative stress parameters were determined. Results: Plasma levels of EPA, DHA and total n-3 fatty acids significantly increased after both interventions. A decreasing trend in triglycerides was more pronounced with salmon than with the fish oil supplement, but the changes noticed were not significant. Although there were no relevant changes in inflammatory marker concentrations at the end of both interventions, significant negative correlations were noticed between total plasma n-3 fatty acids and soluble intercellular adhesion molecule and C-reactive protein throughout the whole intervention period (p  lt  0.05). Among the oxidative stress parameters, intervention with salmon showed a prooxidative effect through a superoxide anion increase (p = 0.025). A relevant positive correlation was also found between its concentration and total plasma n-3 fatty acids (p  lt  0.05). Other oxidative stress markers were not significantly influenced by the dietary interventions applied. Conclusions: Following two sets of recommendations for n-3 fatty acids intake aimed at the general public had only a moderate effect on the selected cardiovascular risk factors in average healthy middle-aged subjects over a short-term period.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population",
volume = "34",
number = "3",
pages = "304-313",
doi = "10.2478/jomb-2014-0039"
}

Đuričić, I., Kotur-Stevuljević, J., Miljković, M., Kerkez, M., Đorđević, V., Đurasić, L.,& Šobajić, S.. (2015). Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 34(3), 304-313.
https://doi.org/10.2478/jomb-2014-0039

Đuričić I, Kotur-Stevuljević J, Miljković M, Kerkez M, Đorđević V, Đurasić L, Šobajić S. Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population. in Journal of Medical Biochemistry. 2015;34(3):304-313.
doi:10.2478/jomb-2014-0039 .

Đuričić, Ivana, Kotur-Stevuljević, Jelena, Miljković, Milica, Kerkez, Mirko, Đorđević, Vladimir, Đurasić, Ljubomir, Šobajić, Slađana, "Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population" in Journal of Medical Biochemistry, 34, no. 3 (2015):304-313,
https://doi.org/10.2478/jomb-2014-0039 . .

TY  - JOUR
AU  - Miljković, Milica
AU  - Đuričić, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Šobajić, Slađana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Kerkez, Mirko
AU  - Đorđević, Vladimir
AU  - Đurasić, Ljubomir
AU  - Spasić, Slavica
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2312
AB  - Paraoxonase-1 activity (PON1) and expression modulation using different pharmacological, nutritional and life-style approaches are current scientific foci. We have assessed the influence of omega-3 fatty acids from different dietary sources on PON1 activity and total oxidative status (TOS) in middle-aged dyslipidemic subjects. The study group consisted of 35 subjects, assigned to use commercial fish oil capsules or 150 g of smoked salmon two times per week during 8 weeks with 6 months of wash-out period. After the wash-out period, the same participants were invited again for the second part of the study, and the study was repeated with reversed interventions. PON1 activity and TOS were measured four times, before and after each supplementation period. Consumption of salmon and fish oil capsules both increased PON1 activity (p  lt  0.001). Pro-oxidative effect (TOS) during the first supplementation period was decreased at the end of supplementation (p  lt  0.001). The present study showed that omega-3 fatty acids, regardless of the dietary source, increased the activity of PON1 in patients with dyslipidaemia. This is possibly a consequence of an enzymatic response to the initially pro-oxidant effect of omega-3 fatty acids, which led to a reduction in oxidative stress after complete supplementation.
PB  - Vup Food Research Inst, Bratislava
T2  - Journal of Food and Nutrition Research
T1  - Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity
VL  - 54
IS  - 4
SP  - 314
EP  - 322
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2312
ER  - 

@article{
author = "Miljković, Milica and Đuričić, Ivana and Kotur-Stevuljević, Jelena and Šobajić, Slađana and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Kerkez, Mirko and Đorđević, Vladimir and Đurasić, Ljubomir and Spasić, Slavica",
year = "2015",
abstract = "Paraoxonase-1 activity (PON1) and expression modulation using different pharmacological, nutritional and life-style approaches are current scientific foci. We have assessed the influence of omega-3 fatty acids from different dietary sources on PON1 activity and total oxidative status (TOS) in middle-aged dyslipidemic subjects. The study group consisted of 35 subjects, assigned to use commercial fish oil capsules or 150 g of smoked salmon two times per week during 8 weeks with 6 months of wash-out period. After the wash-out period, the same participants were invited again for the second part of the study, and the study was repeated with reversed interventions. PON1 activity and TOS were measured four times, before and after each supplementation period. Consumption of salmon and fish oil capsules both increased PON1 activity (p  lt  0.001). Pro-oxidative effect (TOS) during the first supplementation period was decreased at the end of supplementation (p  lt  0.001). The present study showed that omega-3 fatty acids, regardless of the dietary source, increased the activity of PON1 in patients with dyslipidaemia. This is possibly a consequence of an enzymatic response to the initially pro-oxidant effect of omega-3 fatty acids, which led to a reduction in oxidative stress after complete supplementation.",
publisher = "Vup Food Research Inst, Bratislava",
journal = "Journal of Food and Nutrition Research",
title = "Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity",
volume = "54",
number = "4",
pages = "314-322",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2312"
}

Miljković, M., Đuričić, I., Kotur-Stevuljević, J., Šobajić, S., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Kerkez, M., Đorđević, V., Đurasić, L.,& Spasić, S.. (2015). Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity. in Journal of Food and Nutrition Research
Vup Food Research Inst, Bratislava., 54(4), 314-322.
https://hdl.handle.net/21.15107/rcub_farfar_2312

Miljković M, Đuričić I, Kotur-Stevuljević J, Šobajić S, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Kerkez M, Đorđević V, Đurasić L, Spasić S. Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity. in Journal of Food and Nutrition Research. 2015;54(4):314-322.
https://hdl.handle.net/21.15107/rcub_farfar_2312 .

Miljković, Milica, Đuričić, Ivana, Kotur-Stevuljević, Jelena, Šobajić, Slađana, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Kerkez, Mirko, Đorđević, Vladimir, Đurasić, Ljubomir, Spasić, Slavica, "Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity" in Journal of Food and Nutrition Research, 54, no. 4 (2015):314-322,
https://hdl.handle.net/21.15107/rcub_farfar_2312 .

TY  - JOUR
AU  - Đuričić, Ivana
AU  - Mazić, Sanja D.
AU  - Kotur-Stevuljević, Jelena
AU  - Đorđević, Vladimir
AU  - Šobajić, Slađana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2144
AB  - Several dietary recommendations have been made for marine n-3 polyunsaturated fatty acid (PUPA) intake; however, the effectiveness of these fatty acids has not been thoroughly examined. The aim of this study was to investigate whether public-aimed dietary recommendations for long-chain n-3 PUPA from oily fish or fish oil supplements are efficient in optimizing their status in red blood cells (RBCs) and platelets of healthy middle-aged subjects with low customary fish consumption. In a randomized, cross-over trial conducted over an 8-week period and separated by a 6-month washout period, 33 participants received an oily fish (salmon), providing 274 mg eicosapentaenoic acid (EPA) + 671 mg docosahexaenoic acid (DHA) per day, or a commercial fish oil supplement, providing 396 mg EPA + 250 mg DHA per day. Blood samples were collected before and after each intervention period, and RBCs and platelets were used for analysis of fatty acids. After 8 weeks, there were significant increases in EPA and DHA content in RBCs and platelets with both salmon and fish oil capsules. The increase in EPA in both RBCs and platelets was higher with capsules, whereas the increase in DHA in both RBCs and platelets was higher with salmon. In spite of the quantitative and qualitative differences between n-3 fatty acid profiles in salmon and the fish oil supplement, the overall incorporation of these fatty acids into RBCs and platelets did not differ in our short-term study (P>.05). The sum of EPA + DHA significantly increased in both compartments following dietary recommendations for oily fish and fish oil supplements intake in middle-aged healthy subjects with low baseline long-chain n-3 PUPA status, although targeted values with optimal cardioprotective effect of more than 8% were not achieved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Nutrition Research
T1  - Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study
VL  - 34
IS  - 3
SP  - 210
EP  - 218
DO  - 10.1016/j.nutres.2013.12.008
ER  - 

@article{
author = "Đuričić, Ivana and Mazić, Sanja D. and Kotur-Stevuljević, Jelena and Đorđević, Vladimir and Šobajić, Slađana",
year = "2014",
abstract = "Several dietary recommendations have been made for marine n-3 polyunsaturated fatty acid (PUPA) intake; however, the effectiveness of these fatty acids has not been thoroughly examined. The aim of this study was to investigate whether public-aimed dietary recommendations for long-chain n-3 PUPA from oily fish or fish oil supplements are efficient in optimizing their status in red blood cells (RBCs) and platelets of healthy middle-aged subjects with low customary fish consumption. In a randomized, cross-over trial conducted over an 8-week period and separated by a 6-month washout period, 33 participants received an oily fish (salmon), providing 274 mg eicosapentaenoic acid (EPA) + 671 mg docosahexaenoic acid (DHA) per day, or a commercial fish oil supplement, providing 396 mg EPA + 250 mg DHA per day. Blood samples were collected before and after each intervention period, and RBCs and platelets were used for analysis of fatty acids. After 8 weeks, there were significant increases in EPA and DHA content in RBCs and platelets with both salmon and fish oil capsules. The increase in EPA in both RBCs and platelets was higher with capsules, whereas the increase in DHA in both RBCs and platelets was higher with salmon. In spite of the quantitative and qualitative differences between n-3 fatty acid profiles in salmon and the fish oil supplement, the overall incorporation of these fatty acids into RBCs and platelets did not differ in our short-term study (P>.05). The sum of EPA + DHA significantly increased in both compartments following dietary recommendations for oily fish and fish oil supplements intake in middle-aged healthy subjects with low baseline long-chain n-3 PUPA status, although targeted values with optimal cardioprotective effect of more than 8% were not achieved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Nutrition Research",
title = "Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study",
volume = "34",
number = "3",
pages = "210-218",
doi = "10.1016/j.nutres.2013.12.008"
}

Đuričić, I., Mazić, S. D., Kotur-Stevuljević, J., Đorđević, V.,& Šobajić, S.. (2014). Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study. in Nutrition Research
Pergamon-Elsevier Science Ltd, Oxford., 34(3), 210-218.
https://doi.org/10.1016/j.nutres.2013.12.008

Đuričić I, Mazić SD, Kotur-Stevuljević J, Đorđević V, Šobajić S. Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study. in Nutrition Research. 2014;34(3):210-218.
doi:10.1016/j.nutres.2013.12.008 .

Đuričić, Ivana, Mazić, Sanja D., Kotur-Stevuljević, Jelena, Đorđević, Vladimir, Šobajić, Slađana, "Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study" in Nutrition Research, 34, no. 3 (2014):210-218,
https://doi.org/10.1016/j.nutres.2013.12.008 . .