TY  - JOUR
AU  - Manić, Luka
AU  - Wallace, David
AU  - Onganer, Pinar Uysal
AU  - Taalab, Yasmeen
AU  - Farooqi, Ammad
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4101
AB  - Many metals exhibit genotoxic and/or carcinogenic effects. These toxic metals can be found ubiquitously – in drinking water, food, air, general use products, in everyday and occupational settings. Exposure to such carcinogenic metals can result in serious health disorders, including cancer. Arsenic, cadmium, chromium, nickel, and their compounds have already been recognized as carcinogens by the International Agency for Research on Cancer. This review summarizes a wide range of epigenetic mechanisms contributing to carcinogenesis induced by these metals, primarily including, but not limited to, DNA methylation, miRNA regulation, and histone posttranslational modifications. The mechanisms are described and discussed both from a metal-centric and a mechanism-centric standpoint. The review takes a broad perspective, putting the mechanisms in the context of real-life exposure, and aims to assist in guiding future research, particularly with respect to the assessment and control of exposure to carcinogenic metals and novel therapy development.
PB  - Elsevier Inc.
T2  - Toxicology Reports
T1  - Epigenetic mechanisms in metal carcinogenesis
VL  - 9
SP  - 778
EP  - 787
DO  - 10.1016/j.toxrep.2022.03.037
ER  - 

@article{
author = "Manić, Luka and Wallace, David and Onganer, Pinar Uysal and Taalab, Yasmeen and Farooqi, Ammad and Antonijević, Biljana and Buha-Đorđević, Aleksandra",
year = "2022",
abstract = "Many metals exhibit genotoxic and/or carcinogenic effects. These toxic metals can be found ubiquitously – in drinking water, food, air, general use products, in everyday and occupational settings. Exposure to such carcinogenic metals can result in serious health disorders, including cancer. Arsenic, cadmium, chromium, nickel, and their compounds have already been recognized as carcinogens by the International Agency for Research on Cancer. This review summarizes a wide range of epigenetic mechanisms contributing to carcinogenesis induced by these metals, primarily including, but not limited to, DNA methylation, miRNA regulation, and histone posttranslational modifications. The mechanisms are described and discussed both from a metal-centric and a mechanism-centric standpoint. The review takes a broad perspective, putting the mechanisms in the context of real-life exposure, and aims to assist in guiding future research, particularly with respect to the assessment and control of exposure to carcinogenic metals and novel therapy development.",
publisher = "Elsevier Inc.",
journal = "Toxicology Reports",
title = "Epigenetic mechanisms in metal carcinogenesis",
volume = "9",
pages = "778-787",
doi = "10.1016/j.toxrep.2022.03.037"
}

Manić, L., Wallace, D., Onganer, P. U., Taalab, Y., Farooqi, A., Antonijević, B.,& Buha-Đorđević, A.. (2022). Epigenetic mechanisms in metal carcinogenesis. in Toxicology Reports
Elsevier Inc.., 9, 778-787.
https://doi.org/10.1016/j.toxrep.2022.03.037

Manić L, Wallace D, Onganer PU, Taalab Y, Farooqi A, Antonijević B, Buha-Đorđević A. Epigenetic mechanisms in metal carcinogenesis. in Toxicology Reports. 2022;9:778-787.
doi:10.1016/j.toxrep.2022.03.037 .

Manić, Luka, Wallace, David, Onganer, Pinar Uysal, Taalab, Yasmeen, Farooqi, Ammad, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "Epigenetic mechanisms in metal carcinogenesis" in Toxicology Reports, 9 (2022):778-787,
https://doi.org/10.1016/j.toxrep.2022.03.037 . .

TY  - JOUR
AU  - Wallace, David R.
AU  - Taalab, Yasmeen M.
AU  - Heinze, Sarah
AU  - Tariba Lovaković, Sarah
AU  - Pizent, Alica
AU  - Renieri, Elisavit
AU  - Tsatsakis, Aristidis
AU  - Farooqi, Ammad Ahmad
AU  - Javorac, Dragana
AU  - Anđelković, Milena
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3578
AB  - Toxic metals are extensively found in the environment, households, and workplaces and contaminate food and drinking water. The crosstalk between environmental exposure to toxic metals and human diseases has been frequently described. The toxic mechanism of action was classically viewed as the ability to dysregulate the redox status, production of inflammatory mediators and alteration of mitochondrial function. Recently, growing evidence showed that heavy metals might exert their toxicity through microRNAs (miRNA)-short, single-stranded, noncoding molecules that function as positive/negative regulators of gene expression. Aberrant alteration of the endogenous miRNA has been directly implicated in various pathophysiological conditions and signaling pathways, consequently leading to different types of cancer and human diseases. Additionally, the gene-regulatory capacity of miRNAs is particularly valuable in the brain-a complex organ with neurons demonstrating a significant ability to adapt following environmental stimuli. Accordingly, dysregulated miRNAs identified in patients suffering from neurological diseases might serve as biomarkers for the earlier diagnosis and monitoring of disease progression. This review will greatly emphasize the effect of the toxic metals on human miRNA activities and how this contributes to progression of diseases such as cancer and neurodegenerative disorders (NDDs).
PB  - MDPI
T2  - Cells
T1  - Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development
VL  - 9
IS  - 4
DO  - 10.3390/cells9040901
ER  - 

@article{
author = "Wallace, David R. and Taalab, Yasmeen M. and Heinze, Sarah and Tariba Lovaković, Sarah and Pizent, Alica and Renieri, Elisavit and Tsatsakis, Aristidis and Farooqi, Ammad Ahmad and Javorac, Dragana and Anđelković, Milena and Bulat, Zorica and Antonijević, Biljana and Buha-Đorđević, Aleksandra",
year = "2020",
abstract = "Toxic metals are extensively found in the environment, households, and workplaces and contaminate food and drinking water. The crosstalk between environmental exposure to toxic metals and human diseases has been frequently described. The toxic mechanism of action was classically viewed as the ability to dysregulate the redox status, production of inflammatory mediators and alteration of mitochondrial function. Recently, growing evidence showed that heavy metals might exert their toxicity through microRNAs (miRNA)-short, single-stranded, noncoding molecules that function as positive/negative regulators of gene expression. Aberrant alteration of the endogenous miRNA has been directly implicated in various pathophysiological conditions and signaling pathways, consequently leading to different types of cancer and human diseases. Additionally, the gene-regulatory capacity of miRNAs is particularly valuable in the brain-a complex organ with neurons demonstrating a significant ability to adapt following environmental stimuli. Accordingly, dysregulated miRNAs identified in patients suffering from neurological diseases might serve as biomarkers for the earlier diagnosis and monitoring of disease progression. This review will greatly emphasize the effect of the toxic metals on human miRNA activities and how this contributes to progression of diseases such as cancer and neurodegenerative disorders (NDDs).",
publisher = "MDPI",
journal = "Cells",
title = "Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development",
volume = "9",
number = "4",
doi = "10.3390/cells9040901"
}

Wallace, D. R., Taalab, Y. M., Heinze, S., Tariba Lovaković, S., Pizent, A., Renieri, E., Tsatsakis, A., Farooqi, A. A., Javorac, D., Anđelković, M., Bulat, Z., Antonijević, B.,& Buha-Đorđević, A.. (2020). Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development. in Cells
MDPI., 9(4).
https://doi.org/10.3390/cells9040901

Wallace DR, Taalab YM, Heinze S, Tariba Lovaković S, Pizent A, Renieri E, Tsatsakis A, Farooqi AA, Javorac D, Anđelković M, Bulat Z, Antonijević B, Buha-Đorđević A. Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development. in Cells. 2020;9(4).
doi:10.3390/cells9040901 .

Wallace, David R., Taalab, Yasmeen M., Heinze, Sarah, Tariba Lovaković, Sarah, Pizent, Alica, Renieri, Elisavit, Tsatsakis, Aristidis, Farooqi, Ammad Ahmad, Javorac, Dragana, Anđelković, Milena, Bulat, Zorica, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development" in Cells, 9, no. 4 (2020),
https://doi.org/10.3390/cells9040901 . .