TY  - JOUR
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević, Evica
AU  - Antonijević, Biljana
AU  - Stanić, Momcilo
AU  - Kotur-Stevuljević, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jovanović, Miloš
AU  - Boricić, Novica
AU  - Wallace, David
AU  - Bulat, Zorica
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3301
AB  - Background: Cadmium and lead are widespread and non-biodegradable pollutants of great concern to human health. In real life scenarios, we are exposed to mixtures of chemicals rather than single chemicals, and it is therefore of paramount importance to assess their toxicity. In this study, we investigated the toxicity of Cd and Pb alone and as a mixture in an animal model of acute exposure. Methods: Experimental groups received a single treatment of aqueous solution of Cd-chloride (15 and 30 mg/kg body weight (b.w.) and Pb-acetate (150 mg/kg b.w.), while the mixture group received 15 mg Cd/kg b.w. and 150 mg Pb/kg b.w. Toxic effects of individual metals and their mixture were investigated on hematological and biochemical parameters, and the redox status in the plasma, liver, and kidneys of treated Wistar rats. Results: Tissue-specific changes were recorded in various parameters of oxidative damage, while the accumulation of metals in tissues accompanied the disturbances of both hematological and biochemical parameters. It was observed that the level of toxic metals in tissues had a different distribution pattern after mixture and single exposure. Conclusions: Comprehensive observations suggest that exposure to Cd and Pb mixtures produces more pronounced effects compared to the response observed after exposure to single metal solutions. However, further research is needed to confirm toxicokinetic or toxicodynamic interactions between these two toxic metals in the organisms.
PB  - MDPI, Basel
T2  - International Journal of Environmental Research and Public Health
T1  - Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney
VL  - 16
IS  - 2
DO  - 10.3390/ijerph16020274
ER  - 

@article{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Antonijević, Evica and Antonijević, Biljana and Stanić, Momcilo and Kotur-Stevuljević, Jelena and Spasojević-Kalimanovska, Vesna and Jovanović, Miloš and Boricić, Novica and Wallace, David and Bulat, Zorica",
year = "2019",
abstract = "Background: Cadmium and lead are widespread and non-biodegradable pollutants of great concern to human health. In real life scenarios, we are exposed to mixtures of chemicals rather than single chemicals, and it is therefore of paramount importance to assess their toxicity. In this study, we investigated the toxicity of Cd and Pb alone and as a mixture in an animal model of acute exposure. Methods: Experimental groups received a single treatment of aqueous solution of Cd-chloride (15 and 30 mg/kg body weight (b.w.) and Pb-acetate (150 mg/kg b.w.), while the mixture group received 15 mg Cd/kg b.w. and 150 mg Pb/kg b.w. Toxic effects of individual metals and their mixture were investigated on hematological and biochemical parameters, and the redox status in the plasma, liver, and kidneys of treated Wistar rats. Results: Tissue-specific changes were recorded in various parameters of oxidative damage, while the accumulation of metals in tissues accompanied the disturbances of both hematological and biochemical parameters. It was observed that the level of toxic metals in tissues had a different distribution pattern after mixture and single exposure. Conclusions: Comprehensive observations suggest that exposure to Cd and Pb mixtures produces more pronounced effects compared to the response observed after exposure to single metal solutions. However, further research is needed to confirm toxicokinetic or toxicodynamic interactions between these two toxic metals in the organisms.",
publisher = "MDPI, Basel",
journal = "International Journal of Environmental Research and Public Health",
title = "Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney",
volume = "16",
number = "2",
doi = "10.3390/ijerph16020274"
}

Anđelković, M., Buha-Đorđević, A., Antonijević, E., Antonijević, B., Stanić, M., Kotur-Stevuljević, J., Spasojević-Kalimanovska, V., Jovanović, M., Boricić, N., Wallace, D.,& Bulat, Z.. (2019). Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney. in International Journal of Environmental Research and Public Health
MDPI, Basel., 16(2).
https://doi.org/10.3390/ijerph16020274

Anđelković M, Buha-Đorđević A, Antonijević E, Antonijević B, Stanić M, Kotur-Stevuljević J, Spasojević-Kalimanovska V, Jovanović M, Boricić N, Wallace D, Bulat Z. Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney. in International Journal of Environmental Research and Public Health. 2019;16(2).
doi:10.3390/ijerph16020274 .

Anđelković, Milena, Buha-Đorđević, Aleksandra, Antonijević, Evica, Antonijević, Biljana, Stanić, Momcilo, Kotur-Stevuljević, Jelena, Spasojević-Kalimanovska, Vesna, Jovanović, Miloš, Boricić, Novica, Wallace, David, Bulat, Zorica, "Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney" in International Journal of Environmental Research and Public Health, 16, no. 2 (2019),
https://doi.org/10.3390/ijerph16020274 . .