TY  - JOUR
AU  - Radovanović, Jelena
AU  - Antonijević, Biljana
AU  - Kolarević, Stoimir
AU  - Milutinović-Smiljanić, Sanja
AU  - Mandić, Jelena
AU  - Vuković-Gačić, Branka
AU  - Bulat, Zorica
AU  - Ćurčić, Marijana
AU  - Kračun-Kolarević, Margareta
AU  - Sunjog, Karolina
AU  - Kostić-Vuković, Jovana
AU  - Jovanović Marić, Jovana
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Buha-Đorđević, Aleksandra
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Mandinić, Zoran
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3761
AB  - The aims of this study were to: (i) examine the toxic effects of sodium fluoride (NaF) in blood, liver, spleen, and brain cells of Wistar rats after the subacute exposure; (ii) explore the potential protective properties of selenium (Se) against fluoride toxicity after the simultaneous administration. Twenty male Wistar rats, eight weeks old, weighing approximately 140–190 g, were divided into four experimental groups (n = 5) as follows: I control-tap water; II NaF 150 ppm; III NaF 150 ppm and Se 1.5 mg/L; IV Se 1.5 mg/L, and had available water with solutions ad libitum for 28 days. DNA damage detected by comet assay was confirmed in the liver, spleen, and brain cells, but not in blood. Selenium supplementation together with NaF decreased DNA damage in liver and spleen cells. According to the histological findings, no changes were observed in spleen and brain tissues after NaF administration. Unlike the observed Se protective effect on the DNA level, no significant reduction of liver tissue injury was observed after the NaF and Se treatment, resulting in mild inflammation. Data of this study suggest that DNA damage after NaF subacute exposure at moderately high concentration was reduced in liver and spleen cells due to Se supplementation, but a similar change was not seen in the brain.
PB  - Elsevier Ltd
T2  - Chemosphere
T1  - Genotoxicity of fluoride subacute exposure in rats and selenium intervention
VL  - 266
DO  - 10.1016/j.chemosphere.2020.128978
ER  - 

@article{
author = "Radovanović, Jelena and Antonijević, Biljana and Kolarević, Stoimir and Milutinović-Smiljanić, Sanja and Mandić, Jelena and Vuković-Gačić, Branka and Bulat, Zorica and Ćurčić, Marijana and Kračun-Kolarević, Margareta and Sunjog, Karolina and Kostić-Vuković, Jovana and Jovanović Marić, Jovana and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Buha-Đorđević, Aleksandra and Javorac, Dragana and Baralić, Katarina and Mandinić, Zoran",
year = "2021",
abstract = "The aims of this study were to: (i) examine the toxic effects of sodium fluoride (NaF) in blood, liver, spleen, and brain cells of Wistar rats after the subacute exposure; (ii) explore the potential protective properties of selenium (Se) against fluoride toxicity after the simultaneous administration. Twenty male Wistar rats, eight weeks old, weighing approximately 140–190 g, were divided into four experimental groups (n = 5) as follows: I control-tap water; II NaF 150 ppm; III NaF 150 ppm and Se 1.5 mg/L; IV Se 1.5 mg/L, and had available water with solutions ad libitum for 28 days. DNA damage detected by comet assay was confirmed in the liver, spleen, and brain cells, but not in blood. Selenium supplementation together with NaF decreased DNA damage in liver and spleen cells. According to the histological findings, no changes were observed in spleen and brain tissues after NaF administration. Unlike the observed Se protective effect on the DNA level, no significant reduction of liver tissue injury was observed after the NaF and Se treatment, resulting in mild inflammation. Data of this study suggest that DNA damage after NaF subacute exposure at moderately high concentration was reduced in liver and spleen cells due to Se supplementation, but a similar change was not seen in the brain.",
publisher = "Elsevier Ltd",
journal = "Chemosphere",
title = "Genotoxicity of fluoride subacute exposure in rats and selenium intervention",
volume = "266",
doi = "10.1016/j.chemosphere.2020.128978"
}

Radovanović, J., Antonijević, B., Kolarević, S., Milutinović-Smiljanić, S., Mandić, J., Vuković-Gačić, B., Bulat, Z., Ćurčić, M., Kračun-Kolarević, M., Sunjog, K., Kostić-Vuković, J., Jovanović Marić, J., Antonijević-Miljaković, E., Đukić-Ćosić, D., Buha-Đorđević, A., Javorac, D., Baralić, K.,& Mandinić, Z.. (2021). Genotoxicity of fluoride subacute exposure in rats and selenium intervention. in Chemosphere
Elsevier Ltd., 266.
https://doi.org/10.1016/j.chemosphere.2020.128978

Radovanović J, Antonijević B, Kolarević S, Milutinović-Smiljanić S, Mandić J, Vuković-Gačić B, Bulat Z, Ćurčić M, Kračun-Kolarević M, Sunjog K, Kostić-Vuković J, Jovanović Marić J, Antonijević-Miljaković E, Đukić-Ćosić D, Buha-Đorđević A, Javorac D, Baralić K, Mandinić Z. Genotoxicity of fluoride subacute exposure in rats and selenium intervention. in Chemosphere. 2021;266.
doi:10.1016/j.chemosphere.2020.128978 .

Radovanović, Jelena, Antonijević, Biljana, Kolarević, Stoimir, Milutinović-Smiljanić, Sanja, Mandić, Jelena, Vuković-Gačić, Branka, Bulat, Zorica, Ćurčić, Marijana, Kračun-Kolarević, Margareta, Sunjog, Karolina, Kostić-Vuković, Jovana, Jovanović Marić, Jovana, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Buha-Đorđević, Aleksandra, Javorac, Dragana, Baralić, Katarina, Mandinić, Zoran, "Genotoxicity of fluoride subacute exposure in rats and selenium intervention" in Chemosphere, 266 (2021),
https://doi.org/10.1016/j.chemosphere.2020.128978 . .