TY  - JOUR
AU  - Moulis, Jean-Marc
AU  - Bulat, Zorica
AU  - Buha-Đorđević, Aleksandra
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3520
AB  - Metals qualitatively dominate the chemical elements found on Earth, but life has found a use for only a minority of them. Most metals are mobilized as cations, and thereby interact and are processed by living species. Animals are exposed to environmental metals at chronic low concentrations through food, air particles, and other ways, under conditions that are too rarely reproduced in laboratory settings. Actual metal detoxification systems in animals are not many and of limited efficiency which casts doubt on the existence of any safe concentration — a threshold for nonessential metals. Hence the mechanisms of action of toxic metals at very low doses still have to be adequately addressed to provide means for knowledge-based risk assessment that is increasingly requested by diverse communities.
PB  - Elsevier
T2  - Current Opinion in Toxicology
T1  - Threshold in the toxicology of metals: Challenges and pitfalls of the concept
VL  - 19
SP  - 28
EP  - 33
DO  - 10.1016/j.cotox.2019.10.004
ER  - 

@article{
author = "Moulis, Jean-Marc and Bulat, Zorica and Buha-Đorđević, Aleksandra",
year = "2020",
abstract = "Metals qualitatively dominate the chemical elements found on Earth, but life has found a use for only a minority of them. Most metals are mobilized as cations, and thereby interact and are processed by living species. Animals are exposed to environmental metals at chronic low concentrations through food, air particles, and other ways, under conditions that are too rarely reproduced in laboratory settings. Actual metal detoxification systems in animals are not many and of limited efficiency which casts doubt on the existence of any safe concentration — a threshold for nonessential metals. Hence the mechanisms of action of toxic metals at very low doses still have to be adequately addressed to provide means for knowledge-based risk assessment that is increasingly requested by diverse communities.",
publisher = "Elsevier",
journal = "Current Opinion in Toxicology",
title = "Threshold in the toxicology of metals: Challenges and pitfalls of the concept",
volume = "19",
pages = "28-33",
doi = "10.1016/j.cotox.2019.10.004"
}

Moulis, J., Bulat, Z.,& Buha-Đorđević, A.. (2020). Threshold in the toxicology of metals: Challenges and pitfalls of the concept. in Current Opinion in Toxicology
Elsevier., 19, 28-33.
https://doi.org/10.1016/j.cotox.2019.10.004

Moulis J, Bulat Z, Buha-Đorđević A. Threshold in the toxicology of metals: Challenges and pitfalls of the concept. in Current Opinion in Toxicology. 2020;19:28-33.
doi:10.1016/j.cotox.2019.10.004 .

Moulis, Jean-Marc, Bulat, Zorica, Buha-Đorđević, Aleksandra, "Threshold in the toxicology of metals: Challenges and pitfalls of the concept" in Current Opinion in Toxicology, 19 (2020):28-33,
https://doi.org/10.1016/j.cotox.2019.10.004 . .

TY  - JOUR
AU  - Buha, Aleksandra
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Moulis, Jean-Marc
AU  - Goumenou, Marina
AU  - Wallace, David
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3659
AB  - Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation and increased toxicity suggest that Cd may also be involved in other pancreas-mediated diseases, like diabetes. Cd falls into the category of "hyperglycemic" metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to β-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. This review addresses the current evidence for the role of Cd, leading to insulin resistance from human, animal, and in vitro studies. Available data have shown that Cd may affect normal insulin function through multiple pathways. There is evidence that Cd exposure results in the perturbation of the enzymes and modulatory proteins involved in insulin signal transduction at the target tissue and mutations of the insulin receptor. Cd, through well-described mechanisms of oxidative stress, inflammation, and mitochondrial damage, may also alter insulin production in β-cells. More work is necessary to elucidate the mechanisms associated with Cd-mediated insulin resistance.
PB  - MDPI AG
T2  - Toxics
T1  - Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data
VL  - 8
IS  - 3
DO  - 10.3390/TOXICS8030063
ER  - 

@article{
author = "Buha, Aleksandra and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Moulis, Jean-Marc and Goumenou, Marina and Wallace, David",
year = "2020",
abstract = "Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation and increased toxicity suggest that Cd may also be involved in other pancreas-mediated diseases, like diabetes. Cd falls into the category of "hyperglycemic" metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to β-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. This review addresses the current evidence for the role of Cd, leading to insulin resistance from human, animal, and in vitro studies. Available data have shown that Cd may affect normal insulin function through multiple pathways. There is evidence that Cd exposure results in the perturbation of the enzymes and modulatory proteins involved in insulin signal transduction at the target tissue and mutations of the insulin receptor. Cd, through well-described mechanisms of oxidative stress, inflammation, and mitochondrial damage, may also alter insulin production in β-cells. More work is necessary to elucidate the mechanisms associated with Cd-mediated insulin resistance.",
publisher = "MDPI AG",
journal = "Toxics",
title = "Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data",
volume = "8",
number = "3",
doi = "10.3390/TOXICS8030063"
}

Buha, A., Đukić-Ćosić, D., Ćurčić, M., Bulat, Z., Antonijević, B., Moulis, J., Goumenou, M.,& Wallace, D.. (2020). Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data. in Toxics
MDPI AG., 8(3).
https://doi.org/10.3390/TOXICS8030063

Buha A, Đukić-Ćosić D, Ćurčić M, Bulat Z, Antonijević B, Moulis J, Goumenou M, Wallace D. Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data. in Toxics. 2020;8(3).
doi:10.3390/TOXICS8030063 .

Buha, Aleksandra, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Moulis, Jean-Marc, Goumenou, Marina, Wallace, David, "Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data" in Toxics, 8, no. 3 (2020),
https://doi.org/10.3390/TOXICS8030063 . .