TY  - JOUR
AU  - Čakar, Uroš
AU  - Grozdanić, Nada
AU  - Pejin, Boris
AU  - Vasić, Vesna
AU  - Čakar, Mira
AU  - Petrović, Aleksandar V.
AU  - Đorđević, Brižita
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3081
AB  - alpha-Glucosidase inhibitory activity (AGL) of fruit wine samples made from blueberry, black chokeberry, blackberry, raspberry and sour cherry cultivars grown in Serbia was studied using an microvinification procedure. More precisely, both sugar and enzyme were added to the fruit must before fermentation for half of the samples. This increased the extraction of phenolic compounds. All the samples showed higher bioactivity compared to acarbose, the compound used as a positive control. Blueberry (IC50 similar to 27 +/- 1 mu g/ml) and black chokeberry (IC50 similar to 28 +/- 1 mu g/ml) wine samples had the highest values regardless of the vinification method. In addition to this, chlorogenic and caffeic acids were recognised as their key AGL bioactives. Taken all together, the fruit wine samples or their lyophilised extracts may be considered as complementary medicine supplements of potential interest for the control of postprandial hyperglycemia.
PB  - Elsevier Science BV, Amsterdam
T2  - Food Bioscience
T1  - Impact of vinification procedure on fruit wine inhibitory activity against alpha-glucosidase
VL  - 25
SP  - 1
EP  - 7
DO  - 10.1016/j.fbio.2018.06.009
ER  - 

@article{
author = "Čakar, Uroš and Grozdanić, Nada and Pejin, Boris and Vasić, Vesna and Čakar, Mira and Petrović, Aleksandar V. and Đorđević, Brižita",
year = "2018",
abstract = "alpha-Glucosidase inhibitory activity (AGL) of fruit wine samples made from blueberry, black chokeberry, blackberry, raspberry and sour cherry cultivars grown in Serbia was studied using an microvinification procedure. More precisely, both sugar and enzyme were added to the fruit must before fermentation for half of the samples. This increased the extraction of phenolic compounds. All the samples showed higher bioactivity compared to acarbose, the compound used as a positive control. Blueberry (IC50 similar to 27 +/- 1 mu g/ml) and black chokeberry (IC50 similar to 28 +/- 1 mu g/ml) wine samples had the highest values regardless of the vinification method. In addition to this, chlorogenic and caffeic acids were recognised as their key AGL bioactives. Taken all together, the fruit wine samples or their lyophilised extracts may be considered as complementary medicine supplements of potential interest for the control of postprandial hyperglycemia.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Food Bioscience",
title = "Impact of vinification procedure on fruit wine inhibitory activity against alpha-glucosidase",
volume = "25",
pages = "1-7",
doi = "10.1016/j.fbio.2018.06.009"
}

Čakar, U., Grozdanić, N., Pejin, B., Vasić, V., Čakar, M., Petrović, A. V.,& Đorđević, B.. (2018). Impact of vinification procedure on fruit wine inhibitory activity against alpha-glucosidase. in Food Bioscience
Elsevier Science BV, Amsterdam., 25, 1-7.
https://doi.org/10.1016/j.fbio.2018.06.009

Čakar U, Grozdanić N, Pejin B, Vasić V, Čakar M, Petrović AV, Đorđević B. Impact of vinification procedure on fruit wine inhibitory activity against alpha-glucosidase. in Food Bioscience. 2018;25:1-7.
doi:10.1016/j.fbio.2018.06.009 .

Čakar, Uroš, Grozdanić, Nada, Pejin, Boris, Vasić, Vesna, Čakar, Mira, Petrović, Aleksandar V., Đorđević, Brižita, "Impact of vinification procedure on fruit wine inhibitory activity against alpha-glucosidase" in Food Bioscience, 25 (2018):1-7,
https://doi.org/10.1016/j.fbio.2018.06.009 . .

TY  - JOUR
AU  - Vasić, Vesna
AU  - Živanović, MA
AU  - Čakar, Mira
AU  - Savić, Jasmina Z.
AU  - Nedeljković, Jovan M.
AU  - Bugarčić, Živadin
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/591
AB  - The reaction mechanism and thermodynamic parameters of the complex formation between [PdCl(dien)](+) and sulfur-containing ligands L-cysteine and glutathione (GSH) were investigated in the presence of sodium dodecyl sulfate micelles in the pH range 0.5-3.5. The reaction rates were determined under pseudo-first-order conditions (ligand in excess) in the temperature range 276-299 K by using the stopped-flow technique. A reaction mechanism was proposed that consisted of at least two parallel paths involving protonated and zwitterionic forms of thiols. The pH effects on reaction rate were interpreted in terms of the electrostatic interactions between the negatively charged micelle surface and different ionic forms of the ligand species. The calculation of pH-dependent activation parameters (Delta H-not equal and Delta S-not equal) revealed the considerable catalytic effects on the rate of complexation. The entropy of activation is strongly negative in the presence and absence of micelles, which is compatible with an associative reaction mechanism. Copyright
PB  - John Wiley & Sons Ltd, Chichester
T2  - Journal of Physical Organic Chemistry
T1  - Influence of acidity on the reaction between [PdCl(dien)](+) and L-cysteine or glutathione in the presence of sodium dodecyl sulfate micelles
VL  - 18
IS  - 5
SP  - 441
EP  - 447
DO  - 10.1002/poc.880
ER  - 

@article{
author = "Vasić, Vesna and Živanović, MA and Čakar, Mira and Savić, Jasmina Z. and Nedeljković, Jovan M. and Bugarčić, Živadin",
year = "2005",
abstract = "The reaction mechanism and thermodynamic parameters of the complex formation between [PdCl(dien)](+) and sulfur-containing ligands L-cysteine and glutathione (GSH) were investigated in the presence of sodium dodecyl sulfate micelles in the pH range 0.5-3.5. The reaction rates were determined under pseudo-first-order conditions (ligand in excess) in the temperature range 276-299 K by using the stopped-flow technique. A reaction mechanism was proposed that consisted of at least two parallel paths involving protonated and zwitterionic forms of thiols. The pH effects on reaction rate were interpreted in terms of the electrostatic interactions between the negatively charged micelle surface and different ionic forms of the ligand species. The calculation of pH-dependent activation parameters (Delta H-not equal and Delta S-not equal) revealed the considerable catalytic effects on the rate of complexation. The entropy of activation is strongly negative in the presence and absence of micelles, which is compatible with an associative reaction mechanism. Copyright",
publisher = "John Wiley & Sons Ltd, Chichester",
journal = "Journal of Physical Organic Chemistry",
title = "Influence of acidity on the reaction between [PdCl(dien)](+) and L-cysteine or glutathione in the presence of sodium dodecyl sulfate micelles",
volume = "18",
number = "5",
pages = "441-447",
doi = "10.1002/poc.880"
}

Vasić, V., Živanović, M., Čakar, M., Savić, J. Z., Nedeljković, J. M.,& Bugarčić, Ž.. (2005). Influence of acidity on the reaction between [PdCl(dien)](+) and L-cysteine or glutathione in the presence of sodium dodecyl sulfate micelles. in Journal of Physical Organic Chemistry
John Wiley & Sons Ltd, Chichester., 18(5), 441-447.
https://doi.org/10.1002/poc.880

Vasić V, Živanović M, Čakar M, Savić JZ, Nedeljković JM, Bugarčić Ž. Influence of acidity on the reaction between [PdCl(dien)](+) and L-cysteine or glutathione in the presence of sodium dodecyl sulfate micelles. in Journal of Physical Organic Chemistry. 2005;18(5):441-447.
doi:10.1002/poc.880 .

Vasić, Vesna, Živanović, MA, Čakar, Mira, Savić, Jasmina Z., Nedeljković, Jovan M., Bugarčić, Živadin, "Influence of acidity on the reaction between [PdCl(dien)](+) and L-cysteine or glutathione in the presence of sodium dodecyl sulfate micelles" in Journal of Physical Organic Chemistry, 18, no. 5 (2005):441-447,
https://doi.org/10.1002/poc.880 . .

TY  - JOUR
AU  - Vasić, Vesna
AU  - Čakar, Mira
AU  - Savić, J
AU  - Petrović, B
AU  - Nedeljković, J
AU  - Bugarcić, I
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/456
AB  - The effect of sodium dodecyl sulfate (SDS) micelles on the kinetics of the complex formation between [PdCl(dien)](+) and sulfur containing ligands L-cysteine and glutathione (GSH) was investigated by using the stopped-flow technique under pseudo-first order conditions (ligand in excess) in the acidity range from pH 1 to 6. The presence of anionic micelles induced the acceleration of the complex formation in the entire acidity range with the maxima corresponding to the first protolytic constant of the ligands. This effect was interpreted in terms of the attractive electrostatic interaction between reacting species and the micellar surface and their effective concentration in the vicinity of micelles. An increase of the ionic strength leads to a decrease of the rate of complex formation in the presence of anionic micelles due to competition of reactive species with cations originating from inert salt for the micellar surface. The calculation of activation parameters revealed that the entropy of activation is strongly negative in the presence and in the absence of micelles, which is compatible with an associative reaction mechanism.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Polyhedron
T1  - Influence of sodium dodecyl sulfate on the kinetics of complex formation between [PdCl(dien)](+) and sulfur containing ligands L-cysteine and glutathione
VL  - 22
IS  - 2
SP  - 279
EP  - 285
DO  - 10.1016/S0277-5387(02)01307-4
ER  - 

@article{
author = "Vasić, Vesna and Čakar, Mira and Savić, J and Petrović, B and Nedeljković, J and Bugarcić, I",
year = "2003",
abstract = "The effect of sodium dodecyl sulfate (SDS) micelles on the kinetics of the complex formation between [PdCl(dien)](+) and sulfur containing ligands L-cysteine and glutathione (GSH) was investigated by using the stopped-flow technique under pseudo-first order conditions (ligand in excess) in the acidity range from pH 1 to 6. The presence of anionic micelles induced the acceleration of the complex formation in the entire acidity range with the maxima corresponding to the first protolytic constant of the ligands. This effect was interpreted in terms of the attractive electrostatic interaction between reacting species and the micellar surface and their effective concentration in the vicinity of micelles. An increase of the ionic strength leads to a decrease of the rate of complex formation in the presence of anionic micelles due to competition of reactive species with cations originating from inert salt for the micellar surface. The calculation of activation parameters revealed that the entropy of activation is strongly negative in the presence and in the absence of micelles, which is compatible with an associative reaction mechanism.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Polyhedron",
title = "Influence of sodium dodecyl sulfate on the kinetics of complex formation between [PdCl(dien)](+) and sulfur containing ligands L-cysteine and glutathione",
volume = "22",
number = "2",
pages = "279-285",
doi = "10.1016/S0277-5387(02)01307-4"
}

Vasić, V., Čakar, M., Savić, J., Petrović, B., Nedeljković, J.,& Bugarcić, I.. (2003). Influence of sodium dodecyl sulfate on the kinetics of complex formation between [PdCl(dien)](+) and sulfur containing ligands L-cysteine and glutathione. in Polyhedron
Pergamon-Elsevier Science Ltd, Oxford., 22(2), 279-285.
https://doi.org/10.1016/S0277-5387(02)01307-4

Vasić V, Čakar M, Savić J, Petrović B, Nedeljković J, Bugarcić I. Influence of sodium dodecyl sulfate on the kinetics of complex formation between [PdCl(dien)](+) and sulfur containing ligands L-cysteine and glutathione. in Polyhedron. 2003;22(2):279-285.
doi:10.1016/S0277-5387(02)01307-4 .

Vasić, Vesna, Čakar, Mira, Savić, J, Petrović, B, Nedeljković, J, Bugarcić, I, "Influence of sodium dodecyl sulfate on the kinetics of complex formation between [PdCl(dien)](+) and sulfur containing ligands L-cysteine and glutathione" in Polyhedron, 22, no. 2 (2003):279-285,
https://doi.org/10.1016/S0277-5387(02)01307-4 . .

TY  - CONF
AU  - Čakar, Mira
AU  - Vasić, Vesna
AU  - Savić, Jasmina Z.
AU  - Bugarčić, Živadin
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/384
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - The spectrophotometric investigation of the reaction of [Pd(dien)Cl]+ with amino acids
T1  - Spektrofotometrijsko ispitivanje reakcije [Pd(dien)Cl]+ sa amino kiselinama
VL  - 52
IS  - 4
SP  - 506
EP  - 507
UR  - https://hdl.handle.net/21.15107/rcub_farfar_384
ER  - 

@conference{
author = "Čakar, Mira and Vasić, Vesna and Savić, Jasmina Z. and Bugarčić, Živadin",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "The spectrophotometric investigation of the reaction of [Pd(dien)Cl]+ with amino acids, Spektrofotometrijsko ispitivanje reakcije [Pd(dien)Cl]+ sa amino kiselinama",
volume = "52",
number = "4",
pages = "506-507",
url = "https://hdl.handle.net/21.15107/rcub_farfar_384"
}

Čakar, M., Vasić, V., Savić, J. Z.,& Bugarčić, Ž.. (2002). The spectrophotometric investigation of the reaction of [Pd(dien)Cl]+ with amino acids. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 506-507.
https://hdl.handle.net/21.15107/rcub_farfar_384

Čakar M, Vasić V, Savić JZ, Bugarčić Ž. The spectrophotometric investigation of the reaction of [Pd(dien)Cl]+ with amino acids. in Arhiv za farmaciju. 2002;52(4):506-507.
https://hdl.handle.net/21.15107/rcub_farfar_384 .

Čakar, Mira, Vasić, Vesna, Savić, Jasmina Z., Bugarčić, Živadin, "The spectrophotometric investigation of the reaction of [Pd(dien)Cl]+ with amino acids" in Arhiv za farmaciju, 52, no. 4 (2002):506-507,
https://hdl.handle.net/21.15107/rcub_farfar_384 .

TY  - JOUR
AU  - Joksić, Gordana
AU  - Stanković, M
AU  - Vasić, Vesna
AU  - Čakar, Mira
AU  - Jokanović, M
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/243
AB  - Cytotoxic effects of the antiviremic drug ribavirin (1-beta -D-ribofuranosyl-1,2,4-triazole-3-carboxamide) were evaluated in vitro measuring micronucleus formation and cell proliferation kinetics in whole blood cultures employing cytokinesis block (CB) micronucleus test. The cells were exposed to ribavirin doses ranging from 0.05-0.65 mu mol/ml at three different incubation times. The frequency of micronuclei in treated samples demonstrated relatively low ability of ribavirin to induce micronuclei. However, the lowest concentration of ribavirin markedly changed the frequency of mononucleated and multinucleated cells, particularly binucleated ones, which declined significantly. The decline in the frequency of binucleate cells was followed with accumulation of greater number of mononucleate cells. Decreased proliferation potential of lymphocytes treated with ribavirin indicates that cells are arrested prior to metaphase. The present investigation showed that ribavirin is capable to induce a delay in cellular proliferation at all the doses assayed. The study demonstrated that CB micronucleus assay is simple and rapid method that can be used to assess toxic effect of drugs in vitro.
PB  - Slovak Academic Press Ltd, Bratislava
T2  - Neoplasma
T1  - Influence of ribavirin on the micronucleus formation and in vitro proliferation of human lymphocytes
VL  - 47
IS  - 5
SP  - 283
EP  - 287
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2383
ER  - 

@article{
author = "Joksić, Gordana and Stanković, M and Vasić, Vesna and Čakar, Mira and Jokanović, M",
year = "2000",
abstract = "Cytotoxic effects of the antiviremic drug ribavirin (1-beta -D-ribofuranosyl-1,2,4-triazole-3-carboxamide) were evaluated in vitro measuring micronucleus formation and cell proliferation kinetics in whole blood cultures employing cytokinesis block (CB) micronucleus test. The cells were exposed to ribavirin doses ranging from 0.05-0.65 mu mol/ml at three different incubation times. The frequency of micronuclei in treated samples demonstrated relatively low ability of ribavirin to induce micronuclei. However, the lowest concentration of ribavirin markedly changed the frequency of mononucleated and multinucleated cells, particularly binucleated ones, which declined significantly. The decline in the frequency of binucleate cells was followed with accumulation of greater number of mononucleate cells. Decreased proliferation potential of lymphocytes treated with ribavirin indicates that cells are arrested prior to metaphase. The present investigation showed that ribavirin is capable to induce a delay in cellular proliferation at all the doses assayed. The study demonstrated that CB micronucleus assay is simple and rapid method that can be used to assess toxic effect of drugs in vitro.",
publisher = "Slovak Academic Press Ltd, Bratislava",
journal = "Neoplasma",
title = "Influence of ribavirin on the micronucleus formation and in vitro proliferation of human lymphocytes",
volume = "47",
number = "5",
pages = "283-287",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2383"
}

Joksić, G., Stanković, M., Vasić, V., Čakar, M.,& Jokanović, M.. (2000). Influence of ribavirin on the micronucleus formation and in vitro proliferation of human lymphocytes. in Neoplasma
Slovak Academic Press Ltd, Bratislava., 47(5), 283-287.
https://hdl.handle.net/21.15107/rcub_vinar_2383

Joksić G, Stanković M, Vasić V, Čakar M, Jokanović M. Influence of ribavirin on the micronucleus formation and in vitro proliferation of human lymphocytes. in Neoplasma. 2000;47(5):283-287.
https://hdl.handle.net/21.15107/rcub_vinar_2383 .

Joksić, Gordana, Stanković, M, Vasić, Vesna, Čakar, Mira, Jokanović, M, "Influence of ribavirin on the micronucleus formation and in vitro proliferation of human lymphocytes" in Neoplasma, 47, no. 5 (2000):283-287,
https://hdl.handle.net/21.15107/rcub_vinar_2383 .

TY  - JOUR
AU  - Vasić, Vesna
AU  - Premović, Suzana
AU  - Čakar, Mira
AU  - Radak, Bojan B.
AU  - Milovanović, Gordana A.
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/257
AB  - The equilibria of the complex formation between AuCl4-n(OH)n- and I- was studied spectrophotometrically in aqueous solutions containing KI:Au(III)≤2 in the acidity range from 1 M HCl to pH 7 at 25 ºC. From the hydrogen ion and Cl- ion dependence of the absorption spectra, it was found that AuCl2I2- and Au(OH)2I2- complexes were formed. The equilibrium constants of complex formation were determined.
AB  - Ravnoteže obrazovanja kompleksa između AuCl4-n(OH)n i KI ispitivane su spektrofotometrijski u vodenim rastvorima pri odnosu koncentracija KI:Au(III) ≤ 2 u oblasti kiselosti od 1 M HCl do pH 7 na 25 ºC. Iz promene apsorpcionih spektara u zavisnosti od kiselosti sredine i koncentracije Cl- jona nađeno je da se obrazuju kompleksi AuCl2I2- i Au(OH)2I2-. Određene su konstante ravnoteže odgovarajućih reakcija. PR Projekat Ministarstva nauke Republike Srbije.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Spectrophotometric investigations of the reaction between gold(III) and potassium iodide
T1  - Spektrofotometrijsko ispitivanje reakcije zlata(III) sa kalijum-jodidom
VL  - 65
IS  - 5-6
SP  - 345
EP  - 352
UR  - https://hdl.handle.net/21.15107/rcub_vinar_6289
ER  - 

@article{
author = "Vasić, Vesna and Premović, Suzana and Čakar, Mira and Radak, Bojan B. and Milovanović, Gordana A.",
year = "2000",
abstract = "The equilibria of the complex formation between AuCl4-n(OH)n- and I- was studied spectrophotometrically in aqueous solutions containing KI:Au(III)≤2 in the acidity range from 1 M HCl to pH 7 at 25 ºC. From the hydrogen ion and Cl- ion dependence of the absorption spectra, it was found that AuCl2I2- and Au(OH)2I2- complexes were formed. The equilibrium constants of complex formation were determined., Ravnoteže obrazovanja kompleksa između AuCl4-n(OH)n i KI ispitivane su spektrofotometrijski u vodenim rastvorima pri odnosu koncentracija KI:Au(III) ≤ 2 u oblasti kiselosti od 1 M HCl do pH 7 na 25 ºC. Iz promene apsorpcionih spektara u zavisnosti od kiselosti sredine i koncentracije Cl- jona nađeno je da se obrazuju kompleksi AuCl2I2- i Au(OH)2I2-. Određene su konstante ravnoteže odgovarajućih reakcija. PR Projekat Ministarstva nauke Republike Srbije.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Spectrophotometric investigations of the reaction between gold(III) and potassium iodide, Spektrofotometrijsko ispitivanje reakcije zlata(III) sa kalijum-jodidom",
volume = "65",
number = "5-6",
pages = "345-352",
url = "https://hdl.handle.net/21.15107/rcub_vinar_6289"
}

Vasić, V., Premović, S., Čakar, M., Radak, B. B.,& Milovanović, G. A.. (2000). Spectrophotometric investigations of the reaction between gold(III) and potassium iodide. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 65(5-6), 345-352.
https://hdl.handle.net/21.15107/rcub_vinar_6289

Vasić V, Premović S, Čakar M, Radak BB, Milovanović GA. Spectrophotometric investigations of the reaction between gold(III) and potassium iodide. in Journal of the Serbian Chemical Society. 2000;65(5-6):345-352.
https://hdl.handle.net/21.15107/rcub_vinar_6289 .

Vasić, Vesna, Premović, Suzana, Čakar, Mira, Radak, Bojan B., Milovanović, Gordana A., "Spectrophotometric investigations of the reaction between gold(III) and potassium iodide" in Journal of the Serbian Chemical Society, 65, no. 5-6 (2000):345-352,
https://hdl.handle.net/21.15107/rcub_vinar_6289 .

TY  - JOUR
AU  - Čakar, Mira
AU  - Vasić, Vesna
AU  - Petkovska, LT
AU  - Stojić, DL
AU  - Avramov-Ivić, M
AU  - Milovanović, GA
PY  - 1999
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/218
AB  - Newly synthesized oximes, mono and bis imidazole derivatives, which promise to be more effective acetylcholinesterase reactivators than standard antidotes used, were investigated by spectrophotometric and electrochemical methods. The electrochemical investigations confirmed the existence of overlapping equilibria, obtained by spectrophotometric methods. Dissociation constants of those oximes were also obtained by numerical treatment of overlapping equilibria, using the Lavendberg-Marquardt least square method, and when compared with the same for some similar compounds, were found to be very effective acetylcholinesterase reactivators. The distribution of ionic forms of the investigated oximes, as a dependence of pH values, was calculated from the obtained values of dissociation constants. The results indicated that many oxime anions will be available at physiological pH 7.4 and a relative increased ability to reactivate inhibited acetylcholinesterase could be expected.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Spectrophotometric and electrochemical study of protolytic equilibria of some oximes-acetylcholinesterase reactivators
VL  - 20
IS  - 4
SP  - 655
EP  - 662
DO  - 10.1016/S0731-7085(99)00056-4
ER  - 

@article{
author = "Čakar, Mira and Vasić, Vesna and Petkovska, LT and Stojić, DL and Avramov-Ivić, M and Milovanović, GA",
year = "1999",
abstract = "Newly synthesized oximes, mono and bis imidazole derivatives, which promise to be more effective acetylcholinesterase reactivators than standard antidotes used, were investigated by spectrophotometric and electrochemical methods. The electrochemical investigations confirmed the existence of overlapping equilibria, obtained by spectrophotometric methods. Dissociation constants of those oximes were also obtained by numerical treatment of overlapping equilibria, using the Lavendberg-Marquardt least square method, and when compared with the same for some similar compounds, were found to be very effective acetylcholinesterase reactivators. The distribution of ionic forms of the investigated oximes, as a dependence of pH values, was calculated from the obtained values of dissociation constants. The results indicated that many oxime anions will be available at physiological pH 7.4 and a relative increased ability to reactivate inhibited acetylcholinesterase could be expected.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Spectrophotometric and electrochemical study of protolytic equilibria of some oximes-acetylcholinesterase reactivators",
volume = "20",
number = "4",
pages = "655-662",
doi = "10.1016/S0731-7085(99)00056-4"
}

Čakar, M., Vasić, V., Petkovska, L., Stojić, D., Avramov-Ivić, M.,& Milovanović, G.. (1999). Spectrophotometric and electrochemical study of protolytic equilibria of some oximes-acetylcholinesterase reactivators. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 20(4), 655-662.
https://doi.org/10.1016/S0731-7085(99)00056-4

Čakar M, Vasić V, Petkovska L, Stojić D, Avramov-Ivić M, Milovanović G. Spectrophotometric and electrochemical study of protolytic equilibria of some oximes-acetylcholinesterase reactivators. in Journal of Pharmaceutical and Biomedical Analysis. 1999;20(4):655-662.
doi:10.1016/S0731-7085(99)00056-4 .

Čakar, Mira, Vasić, Vesna, Petkovska, LT, Stojić, DL, Avramov-Ivić, M, Milovanović, GA, "Spectrophotometric and electrochemical study of protolytic equilibria of some oximes-acetylcholinesterase reactivators" in Journal of Pharmaceutical and Biomedical Analysis, 20, no. 4 (1999):655-662,
https://doi.org/10.1016/S0731-7085(99)00056-4 . .