TY  - JOUR
AU  - Pavlović, Dragana
AU  - Dobrić, Silva
AU  - Stojanović, Nikola
AU  - Zlatković, Bojan
AU  - Matejić, Jelena
AU  - Kovačević, Nada
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5568
AB  - There is little data on the phytochemical/pharmacological properties of Erica spiculifolia Salisb. (syn. Bruckentalia spiculifolia (Salisb.) Rchb.). This study examines the antioxidative and anti-inflammatory activities of different extracts and fractions of E. spiculifolia in vitro on isolated rat peritoneal macrophages, in the carrageenan-induced rat paw oedema test, BSA test, and two complementary antioxidant assays. Ethanolic extracts of leaves, flowers, and aboveground parts, and petroleum ether, ether, ethyl acetate, and water fractionations of the ethanol extract of E. spiculifolia applied at doses of 50–200 mg/kg p.o. exhibited dose-dependent anti-inflammatory activity comparable with indomethacin. All tested samples, except for the petroleum ether fraction, exerted excellent in vitro antioxidant activity, and all of them exhibited significant and similar inhibition of BSA denaturation comparable with diclofenac. Ethanolic extract of the aboveground parts obtained by percolation, ethyl acetate and water fractions had the highest efficiency, attenuating inflammation by more than 50% in the lowest applied concentration alongside exceptional radical scavenging activity.
PB  - Taylor & Francis
T2  - Natural Product Research
T1  - Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions
DO  - 10.1080/14786419.2023.2301677
DO  - 001141584900001
ER  - 

@article{
author = "Pavlović, Dragana and Dobrić, Silva and Stojanović, Nikola and Zlatković, Bojan and Matejić, Jelena and Kovačević, Nada",
year = "2024",
abstract = "There is little data on the phytochemical/pharmacological properties of Erica spiculifolia Salisb. (syn. Bruckentalia spiculifolia (Salisb.) Rchb.). This study examines the antioxidative and anti-inflammatory activities of different extracts and fractions of E. spiculifolia in vitro on isolated rat peritoneal macrophages, in the carrageenan-induced rat paw oedema test, BSA test, and two complementary antioxidant assays. Ethanolic extracts of leaves, flowers, and aboveground parts, and petroleum ether, ether, ethyl acetate, and water fractionations of the ethanol extract of E. spiculifolia applied at doses of 50–200 mg/kg p.o. exhibited dose-dependent anti-inflammatory activity comparable with indomethacin. All tested samples, except for the petroleum ether fraction, exerted excellent in vitro antioxidant activity, and all of them exhibited significant and similar inhibition of BSA denaturation comparable with diclofenac. Ethanolic extract of the aboveground parts obtained by percolation, ethyl acetate and water fractions had the highest efficiency, attenuating inflammation by more than 50% in the lowest applied concentration alongside exceptional radical scavenging activity.",
publisher = "Taylor & Francis",
journal = "Natural Product Research",
title = "Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions",
doi = "10.1080/14786419.2023.2301677, 001141584900001"
}

Pavlović, D., Dobrić, S., Stojanović, N., Zlatković, B., Matejić, J.,& Kovačević, N.. (2024). Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions. in Natural Product Research
Taylor & Francis..
https://doi.org/10.1080/14786419.2023.2301677

Pavlović D, Dobrić S, Stojanović N, Zlatković B, Matejić J, Kovačević N. Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions. in Natural Product Research. 2024;.
doi:10.1080/14786419.2023.2301677 .

Pavlović, Dragana, Dobrić, Silva, Stojanović, Nikola, Zlatković, Bojan, Matejić, Jelena, Kovačević, Nada, "Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions" in Natural Product Research (2024),
https://doi.org/10.1080/14786419.2023.2301677 . .