TY  - JOUR
AU  - Lukačišinová, Anna
AU  - Reissigová, Jindra
AU  - Ortner-Hadžiabdić, Maja
AU  - Brkić, Jovana
AU  - Okuyan, Betul
AU  - Volmer, Daisy
AU  - Tadić, Ivana
AU  - Modamio, Pilar
AU  - Mariño, Eduardo
AU  - Tachkov, Konstantine
AU  - Liperotti, Rosa
AU  - Onder, Graziano
AU  - Finne-Soveri, Harriet
AU  - van Hout, Hein
AU  - Howard, Elizabeth P.
AU  - Fialová, Daniela
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5563
AB  - Background: The use of benzodiazepines (BZDs) in older population is often accompanied by drug-related complications. Inappropriate BZD use significantly alters older adults’ clinical and functional status. This study compares the prevalence, prescribing patterns and factors associated with BZD use in community-dwelling older patients in 7 European countries. Methods: International, cross-sectional study was conducted in community-dwelling older adults (65 +) in the Czech Republic, Serbia, Estonia, Bulgaria, Croatia, Turkey, and Spain between Feb2019 and Mar2020. Structured and standardized questionnaire based on interRAI assessment scales was applied. Logistic regression was used to evaluate factors associated with BZD use. Results: Out of 2,865 older patients (mean age 73.2 years ± 6.8, 61.2% women) 14.9% were BZD users. The highest prevalence of BZD use was identified in Croatia (35.5%), Spain (33.5%) and Serbia (31.3%). The most frequently prescribed BZDs were diazepam (27.9% of 426 BZD users), alprazolam (23.7%), bromazepam (22.8%) and lorazepam (16.7%). Independent factors associated with BZD use were female gender (OR 1.58, 95%CI 1.19–2.10), hyperpolypharmacy (OR 1.97, 95%CI 1.22–3.16), anxiety (OR 4.26, 95%CI 2.86–6.38), sleeping problems (OR 4.47, 95%CI 3.38–5.92), depression (OR 1.95, 95%CI 1.29–2.95), repetitive anxious complaints (OR 1.77, 95%CI 1.29–2.42), problems with syncope (OR 1.78, 95%CI 1.03–3.06), and loss of appetite (OR 0.60, 95%CI 0.38–0.94). In comparison to Croatia, residing in other countries was associated with lower odds of BZD use (ORs varied from 0.49 (95%CI 0.32–0.75) in Spain to 0.01 (95%CI 0.00–0.03) in Turkey), excluding Serbia (OR 1.11, 95%CI 0.79–1.56). Conclusions: Despite well-known negative effects, BZDs are still frequently prescribed in older outpatient population in European countries. Principles of safer geriatric prescribing and effective deprescribing strategies should be individually applied in older BZD users.
PB  - BioMed Central Ltd
T2  - BMC Geriatrics
T1  - Prevalence, country-specific prescribing patterns and determinants of benzodiazepine use in community-residing older adults in 7 European countries
VL  - 24
IS  - 1
DO  - 10.1186/s12877-024-04742-7
ER  - 

@article{
author = "Lukačišinová, Anna and Reissigová, Jindra and Ortner-Hadžiabdić, Maja and Brkić, Jovana and Okuyan, Betul and Volmer, Daisy and Tadić, Ivana and Modamio, Pilar and Mariño, Eduardo and Tachkov, Konstantine and Liperotti, Rosa and Onder, Graziano and Finne-Soveri, Harriet and van Hout, Hein and Howard, Elizabeth P. and Fialová, Daniela",
year = "2024",
abstract = "Background: The use of benzodiazepines (BZDs) in older population is often accompanied by drug-related complications. Inappropriate BZD use significantly alters older adults’ clinical and functional status. This study compares the prevalence, prescribing patterns and factors associated with BZD use in community-dwelling older patients in 7 European countries. Methods: International, cross-sectional study was conducted in community-dwelling older adults (65 +) in the Czech Republic, Serbia, Estonia, Bulgaria, Croatia, Turkey, and Spain between Feb2019 and Mar2020. Structured and standardized questionnaire based on interRAI assessment scales was applied. Logistic regression was used to evaluate factors associated with BZD use. Results: Out of 2,865 older patients (mean age 73.2 years ± 6.8, 61.2% women) 14.9% were BZD users. The highest prevalence of BZD use was identified in Croatia (35.5%), Spain (33.5%) and Serbia (31.3%). The most frequently prescribed BZDs were diazepam (27.9% of 426 BZD users), alprazolam (23.7%), bromazepam (22.8%) and lorazepam (16.7%). Independent factors associated with BZD use were female gender (OR 1.58, 95%CI 1.19–2.10), hyperpolypharmacy (OR 1.97, 95%CI 1.22–3.16), anxiety (OR 4.26, 95%CI 2.86–6.38), sleeping problems (OR 4.47, 95%CI 3.38–5.92), depression (OR 1.95, 95%CI 1.29–2.95), repetitive anxious complaints (OR 1.77, 95%CI 1.29–2.42), problems with syncope (OR 1.78, 95%CI 1.03–3.06), and loss of appetite (OR 0.60, 95%CI 0.38–0.94). In comparison to Croatia, residing in other countries was associated with lower odds of BZD use (ORs varied from 0.49 (95%CI 0.32–0.75) in Spain to 0.01 (95%CI 0.00–0.03) in Turkey), excluding Serbia (OR 1.11, 95%CI 0.79–1.56). Conclusions: Despite well-known negative effects, BZDs are still frequently prescribed in older outpatient population in European countries. Principles of safer geriatric prescribing and effective deprescribing strategies should be individually applied in older BZD users.",
publisher = "BioMed Central Ltd",
journal = "BMC Geriatrics",
title = "Prevalence, country-specific prescribing patterns and determinants of benzodiazepine use in community-residing older adults in 7 European countries",
volume = "24",
number = "1",
doi = "10.1186/s12877-024-04742-7"
}

Lukačišinová, A., Reissigová, J., Ortner-Hadžiabdić, M., Brkić, J., Okuyan, B., Volmer, D., Tadić, I., Modamio, P., Mariño, E., Tachkov, K., Liperotti, R., Onder, G., Finne-Soveri, H., van Hout, H., Howard, E. P.,& Fialová, D.. (2024). Prevalence, country-specific prescribing patterns and determinants of benzodiazepine use in community-residing older adults in 7 European countries. in BMC Geriatrics
BioMed Central Ltd., 24(1).
https://doi.org/10.1186/s12877-024-04742-7

Lukačišinová A, Reissigová J, Ortner-Hadžiabdić M, Brkić J, Okuyan B, Volmer D, Tadić I, Modamio P, Mariño E, Tachkov K, Liperotti R, Onder G, Finne-Soveri H, van Hout H, Howard EP, Fialová D. Prevalence, country-specific prescribing patterns and determinants of benzodiazepine use in community-residing older adults in 7 European countries. in BMC Geriatrics. 2024;24(1).
doi:10.1186/s12877-024-04742-7 .

Lukačišinová, Anna, Reissigová, Jindra, Ortner-Hadžiabdić, Maja, Brkić, Jovana, Okuyan, Betul, Volmer, Daisy, Tadić, Ivana, Modamio, Pilar, Mariño, Eduardo, Tachkov, Konstantine, Liperotti, Rosa, Onder, Graziano, Finne-Soveri, Harriet, van Hout, Hein, Howard, Elizabeth P., Fialová, Daniela, "Prevalence, country-specific prescribing patterns and determinants of benzodiazepine use in community-residing older adults in 7 European countries" in BMC Geriatrics, 24, no. 1 (2024),
https://doi.org/10.1186/s12877-024-04742-7 . .

TY  - JOUR
AU  - Brkić, Jovana
AU  - Fialova, Daniela
AU  - Okuyan, Betul
AU  - Kummer, Ingrid
AU  - Šesto, Sofija
AU  - Capiau, Andreas
AU  - Ortner Hadžiabdić, Maja
AU  - Tachkov, Konstantin
AU  - Bobrova, Veera
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4345
PB  - Nature Research
T2  - Scientific Reports
T1  - Author Correction: Prevalence of potentially inappropriate prescribing in older adults in Central and Eastern Europe: a systematic review and synthesis without meta‑analysis
VL  - 12
IS  - 1
DO  - 10.1038/s41598-022-25155-9
ER  - 

@article{
author = "Brkić, Jovana and Fialova, Daniela and Okuyan, Betul and Kummer, Ingrid and Šesto, Sofija and Capiau, Andreas and Ortner Hadžiabdić, Maja and Tachkov, Konstantin and Bobrova, Veera",
year = "2022",
publisher = "Nature Research",
journal = "Scientific Reports",
title = "Author Correction: Prevalence of potentially inappropriate prescribing in older adults in Central and Eastern Europe: a systematic review and synthesis without meta‑analysis",
volume = "12",
number = "1",
doi = "10.1038/s41598-022-25155-9"
}

Brkić, J., Fialova, D., Okuyan, B., Kummer, I., Šesto, S., Capiau, A., Ortner Hadžiabdić, M., Tachkov, K.,& Bobrova, V.. (2022). Author Correction: Prevalence of potentially inappropriate prescribing in older adults in Central and Eastern Europe: a systematic review and synthesis without meta‑analysis. in Scientific Reports
Nature Research., 12(1).
https://doi.org/10.1038/s41598-022-25155-9

Brkić J, Fialova D, Okuyan B, Kummer I, Šesto S, Capiau A, Ortner Hadžiabdić M, Tachkov K, Bobrova V. Author Correction: Prevalence of potentially inappropriate prescribing in older adults in Central and Eastern Europe: a systematic review and synthesis without meta‑analysis. in Scientific Reports. 2022;12(1).
doi:10.1038/s41598-022-25155-9 .

Brkić, Jovana, Fialova, Daniela, Okuyan, Betul, Kummer, Ingrid, Šesto, Sofija, Capiau, Andreas, Ortner Hadžiabdić, Maja, Tachkov, Konstantin, Bobrova, Veera, "Author Correction: Prevalence of potentially inappropriate prescribing in older adults in Central and Eastern Europe: a systematic review and synthesis without meta‑analysis" in Scientific Reports, 12, no. 1 (2022),
https://doi.org/10.1038/s41598-022-25155-9 . .

TY  - JOUR
AU  - Brkić, Jovana
AU  - Fialova, Daniela
AU  - Okuyan, Betul
AU  - Kummer, Ingrid
AU  - Šesto, Sofija
AU  - Capiau, Andreas
AU  - Ortner Hadžiabdić, Maja
AU  - Tachkov, Konstantin
AU  - Bobrova, Veera
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4286
AB  - We aimed to systematically review the prevalence of potentially inappropriate prescribing (PIP) in older adults in Central and Eastern Europe (CEE) in all care settings. We searched Embase and MEDLINE (up to June 2019) and checked the reference lists of the included studies and relevant reviews. Eligible studies used validated explicit or implicit tools to assess the PIP prevalence in older adults in CEE. All study designs were considered, except case‒control studies and case series. We assessed the risk of bias using the Joanna Briggs Institute Prevalence Critical Appraisal Tool and the certainty of evidence using the GRADE approach. Meta-analysis was inappropriate due to heterogeneity in the outcome measurements. Therefore, we used the synthesis without meta-analysis approach—summarizing effect estimates method. This review included twenty-seven studies with 139,693 participants. Most studies were cross-sectional and conducted in high-income countries. The data synthesis across 26 studies revealed the PIP prevalence: the median was 34.6%, the interquartile range was 25.9–63.2%, and the range was 6.5–95.8%. The certainty of this evidence was very low due to the risk of bias, imprecision, and inconsistency. These findings show that PIP is a prevalent issue in the CEE region. Further well-designed studies conducted across countries are needed to strengthen the existing evidence and increase the generalizability of findings.
PB  - Nature Research
T2  - Scientific Reports
T1  - Prevalence of potentially inappropriate prescribing in older adults in Central and Eastern Europe: a systematic review and synthesis without meta-analysis
VL  - 12
IS  - 1
DO  - 10.1038/s41598-022-19860-8
ER  - 

@article{
author = "Brkić, Jovana and Fialova, Daniela and Okuyan, Betul and Kummer, Ingrid and Šesto, Sofija and Capiau, Andreas and Ortner Hadžiabdić, Maja and Tachkov, Konstantin and Bobrova, Veera",
year = "2022",
abstract = "We aimed to systematically review the prevalence of potentially inappropriate prescribing (PIP) in older adults in Central and Eastern Europe (CEE) in all care settings. We searched Embase and MEDLINE (up to June 2019) and checked the reference lists of the included studies and relevant reviews. Eligible studies used validated explicit or implicit tools to assess the PIP prevalence in older adults in CEE. All study designs were considered, except case‒control studies and case series. We assessed the risk of bias using the Joanna Briggs Institute Prevalence Critical Appraisal Tool and the certainty of evidence using the GRADE approach. Meta-analysis was inappropriate due to heterogeneity in the outcome measurements. Therefore, we used the synthesis without meta-analysis approach—summarizing effect estimates method. This review included twenty-seven studies with 139,693 participants. Most studies were cross-sectional and conducted in high-income countries. The data synthesis across 26 studies revealed the PIP prevalence: the median was 34.6%, the interquartile range was 25.9–63.2%, and the range was 6.5–95.8%. The certainty of this evidence was very low due to the risk of bias, imprecision, and inconsistency. These findings show that PIP is a prevalent issue in the CEE region. Further well-designed studies conducted across countries are needed to strengthen the existing evidence and increase the generalizability of findings.",
publisher = "Nature Research",
journal = "Scientific Reports",
title = "Prevalence of potentially inappropriate prescribing in older adults in Central and Eastern Europe: a systematic review and synthesis without meta-analysis",
volume = "12",
number = "1",
doi = "10.1038/s41598-022-19860-8"
}

Brkić, J., Fialova, D., Okuyan, B., Kummer, I., Šesto, S., Capiau, A., Ortner Hadžiabdić, M., Tachkov, K.,& Bobrova, V.. (2022). Prevalence of potentially inappropriate prescribing in older adults in Central and Eastern Europe: a systematic review and synthesis without meta-analysis. in Scientific Reports
Nature Research., 12(1).
https://doi.org/10.1038/s41598-022-19860-8

Brkić J, Fialova D, Okuyan B, Kummer I, Šesto S, Capiau A, Ortner Hadžiabdić M, Tachkov K, Bobrova V. Prevalence of potentially inappropriate prescribing in older adults in Central and Eastern Europe: a systematic review and synthesis without meta-analysis. in Scientific Reports. 2022;12(1).
doi:10.1038/s41598-022-19860-8 .

Brkić, Jovana, Fialova, Daniela, Okuyan, Betul, Kummer, Ingrid, Šesto, Sofija, Capiau, Andreas, Ortner Hadžiabdić, Maja, Tachkov, Konstantin, Bobrova, Veera, "Prevalence of potentially inappropriate prescribing in older adults in Central and Eastern Europe: a systematic review and synthesis without meta-analysis" in Scientific Reports, 12, no. 1 (2022),
https://doi.org/10.1038/s41598-022-19860-8 . .