@article{
author = "Klisić, Aleksandra and Malenica, Maja and Kostadinović, Jelena and Kocić, Gordana and Ninić, Ana",
year = "2023",
abstract = "Background: Given the fact that the studies that examined
oxidative stress in relation to obesity that included late
adolescents are scarce and show inconclusive results we
aimed to investigate a wide spectrum of nitro-oxidative
stress biomarkers i.e., malondialdehyde (MDA), xanthine
oxidase (XO), xanthine oxidoreductase (XOD), xanthine
dehydrogenase (XDH), advanced oxidation protein
products (AOPP) and nitric oxide products (NOx), as well
as an antioxidative enzyme, i.e., catalase (CAT) in relation
with obesity in the cohort of adolescent girls ages between
16 and 19 years old.
Methods: A total of 59 teenage girls were included in this
cross-sectional study. Binary logistic regression analysis was
performed to examine possible associations between bio-
chemical and nitro-oxidative stress markers and body mass
index (BMI).
Results: There were not significant differences between
oxidative stress markers between normal weight and
overweight/obese girls (i.e., AOPP, XOD, XO, XDH) and
CAT, except for MDA (p<0.001) and NOx (p=0.010)
concentrations which were significantly higher in overweight/obese adolescent girls. Positive associations
were evident between BMI and high sensitivity C-reactive
protein (hsCRP) (OR=2.495), BMI and uric acid
(OR=1.024) and BMI and MDA (OR=1.062).
Multivariable binary regression analysis demonstrated sig-
nificant independent associations of BMI and hsCRP
(OR=2.150) and BMI and MDA (OR=1.105). Even
76.3% of the variation in BMI could be explained with this
Model.
Conclusions: Inflammation (as measured with hsCRP) and
oxidative stress (as determined with MDA) independently
correlated with BMI in teenage girls., Uvod: Imajući u vidu činjenicu da je malo studija koje su ispitivale povezanost oksidativnog stresa i gojaznosti kod adolescenata i da iste pokazuju oprečne rezultate, cilj istraživanja je bio da se ispita povezanost širokog spektra biomarkera nitro-oksidativnog stresa tj. malondialdehida (MDA), ksantin oksidaze (XO), ksantin oksidoreduktaze (XOD), ksantin dehidrogenaze (XDH), produkata uznapredovale oksidacije proteina (AOPP) i produkata azot-monoksida (NOx), kao i enzima antioksidativne zaštite, tj. katalaze (CAT) i gojaznosti u kohorti adolescentkinja starosne dobi izme|u 16 i 19 godina. Metode: Ukupno 59 tinejdžerki je uključeno u ovu studiju preseka. Binarna logistička regresija je primenjena u cilju ispitivanja potencijalne povezanosti između biohemijskih markera i markera nitro-oksidativnog stresa i indeksa telesne mase (ITM). Rezultati: Nije uočena razlika u biomarkerima oksidativnog stresa između normalno uhranjenih i predgojaznih/gojaznih adolescentkinja (odnosno AOPP, XOD, XO, XDH) i CAT, osim u vrednostima MDA (p<0,001) i NOx (p=0,010) koje su bile značajno veće kod predgojaznih/gojaznih adolescentkinja. Pozitivna korelacija je utvrđena izme|u ITM-a i visokosenzitivnog C-reaktivnog proteina (hsCRP) (OR=2,495), ITM-a i mokraćne kiseline (OR=1,024) i ITM-a i MDA (OR=1,062). Multivarijanta binarna regresija je pokazala nezavisnu povezanost ITM-a i hsCRP (OR=2,150), kao i ITM-a i MDA (OR=1,105). Čak 76,3% varijabiliteta ITM-a može biti objašnjeno ovim modelom. Zaključak: Inflamacija (merena hsCRP-om) i oksidativni stres (meren malondialdehidom) nezavisno koreliraju sa ITM kod adolescentkinja.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd",
journal = "Journal of Medical Biochemistry",
title = "Malondialdehyde as an independent predictor of body mass index in adolescent girls, Malondialdehid kao nezavisan prediktor indeksa telesne mase kod adolescentkinja",
volume = "42",
number = "2",
pages = "224-231",
doi = "10.5937/jomb0-39044"
}
