TY  - JOUR
AU  - Korčok, Davor J.
AU  - Tršić-Milanović, Nada
AU  - Ilić, Marija
AU  - Mitić, Bogdan
AU  - Đorđević, Brižita
AU  - Ivanović, Nevena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3820
AB  - In recent decades, probiotic products have been increasingly used to prevent certain gastrointestinal and urogenital disorders, to improve the general condition of the body and as a supplement to pharmacological therapy. They are most often registered as dietary supplements, and less often as drugs in the form of capsules, powders, and solutions. Optimization of technological processes of production and packaging of these products aims to maintain probiotic characteristics while adhering to all criteria during production that ensure quality, bioavailability and optimal therapeutic effects. In this paper, the importance of choosing primary and secondary packaging materials was explored with the aim of preserving the viability of probiotic cells in capsules for two years, i.e. during the shelf life. By comparing the applications of polyvinyl chloride (PVC) and PVC/polyvinylidene chloride/polyethylene blister foils, better protection of probiotic cells was observed by applying the multilayer foil. In addition, in this research, further improvements of probiotic cell protection were achieved by applying a secondary packing-flow pack bag with inert gas for storing multilayered blisters.
AB  - Probiotski proizvodi se poslednjih decenija sve više koriste za prevenciju određenih gastrointestinalnih i urogenitalnih poremećaja, za poboljšanje opšteg stanja organi-zma i kao dopuna farmakološke terapije. Najčešće su registrovani kao dijetetski suple-menti, a ređe kao lekovi u obliku kapsula, praškova i rastvora. Optimizacija tehnoloških procesa proizvodnje i pakovanje ovih proizvoda ima za cilj održavanje probiotskih karakteristika  uz istovremeno pridržavanje svih kriterijuma u toku proizvodnje koji osiguravaju kvalitet, biološku raspoloživost i optimalno terapijsko dejstvo U ovom radu razmatran je značaj izbora primarnog i sekundarnog materijala za pakovanje sa ciljem očuvanja vijabilnost probiotskih ćelija u kapsulama tokom dve godine tj. tokom roka upotrebe. Poređenjem primene PVC (polivinil hlorid) i PVC/poliviniliden  hlorid/poli-etilen (PVC/PVdC/PE) blister folija uočena je bolja zaštita probotskih ćelija od kiseonika i vlage primenom višeslojene folije. Dodatne efekte zaštite probiotskih ćelija u ovom radu potvrdjene su primenom dodatne zaštite blistera upotrebom sekundarnog pakovanja (engl. flow pack) kesice sa inertni gasom.
PB  - Association of the Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Improving the viability and stability of a probiotic product with Saccharomyces boulardii DBVPG
T1  - Unapređenje vijabilnosti i stabilnosti probiotskog proizvoda sa Saccharomyces boulardii DBVPG
VL  - 75
IS  - 1
SP  - 25
EP  - 30
DO  - 10.2298/HEMIND201211008K
ER  - 

@article{
author = "Korčok, Davor J. and Tršić-Milanović, Nada and Ilić, Marija and Mitić, Bogdan and Đorđević, Brižita and Ivanović, Nevena",
year = "2021",
abstract = "In recent decades, probiotic products have been increasingly used to prevent certain gastrointestinal and urogenital disorders, to improve the general condition of the body and as a supplement to pharmacological therapy. They are most often registered as dietary supplements, and less often as drugs in the form of capsules, powders, and solutions. Optimization of technological processes of production and packaging of these products aims to maintain probiotic characteristics while adhering to all criteria during production that ensure quality, bioavailability and optimal therapeutic effects. In this paper, the importance of choosing primary and secondary packaging materials was explored with the aim of preserving the viability of probiotic cells in capsules for two years, i.e. during the shelf life. By comparing the applications of polyvinyl chloride (PVC) and PVC/polyvinylidene chloride/polyethylene blister foils, better protection of probiotic cells was observed by applying the multilayer foil. In addition, in this research, further improvements of probiotic cell protection were achieved by applying a secondary packing-flow pack bag with inert gas for storing multilayered blisters., Probiotski proizvodi se poslednjih decenija sve više koriste za prevenciju određenih gastrointestinalnih i urogenitalnih poremećaja, za poboljšanje opšteg stanja organi-zma i kao dopuna farmakološke terapije. Najčešće su registrovani kao dijetetski suple-menti, a ređe kao lekovi u obliku kapsula, praškova i rastvora. Optimizacija tehnoloških procesa proizvodnje i pakovanje ovih proizvoda ima za cilj održavanje probiotskih karakteristika  uz istovremeno pridržavanje svih kriterijuma u toku proizvodnje koji osiguravaju kvalitet, biološku raspoloživost i optimalno terapijsko dejstvo U ovom radu razmatran je značaj izbora primarnog i sekundarnog materijala za pakovanje sa ciljem očuvanja vijabilnost probiotskih ćelija u kapsulama tokom dve godine tj. tokom roka upotrebe. Poređenjem primene PVC (polivinil hlorid) i PVC/poliviniliden  hlorid/poli-etilen (PVC/PVdC/PE) blister folija uočena je bolja zaštita probotskih ćelija od kiseonika i vlage primenom višeslojene folije. Dodatne efekte zaštite probiotskih ćelija u ovom radu potvrdjene su primenom dodatne zaštite blistera upotrebom sekundarnog pakovanja (engl. flow pack) kesice sa inertni gasom.",
publisher = "Association of the Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Improving the viability and stability of a probiotic product with Saccharomyces boulardii DBVPG, Unapređenje vijabilnosti i stabilnosti probiotskog proizvoda sa Saccharomyces boulardii DBVPG",
volume = "75",
number = "1",
pages = "25-30",
doi = "10.2298/HEMIND201211008K"
}

Korčok, D. J., Tršić-Milanović, N., Ilić, M., Mitić, B., Đorđević, B.,& Ivanović, N.. (2021). Improving the viability and stability of a probiotic product with Saccharomyces boulardii DBVPG. in Hemijska industrija
Association of the Chemical Engineers of Serbia., 75(1), 25-30.
https://doi.org/10.2298/HEMIND201211008K

Korčok DJ, Tršić-Milanović N, Ilić M, Mitić B, Đorđević B, Ivanović N. Improving the viability and stability of a probiotic product with Saccharomyces boulardii DBVPG. in Hemijska industrija. 2021;75(1):25-30.
doi:10.2298/HEMIND201211008K .

Korčok, Davor J., Tršić-Milanović, Nada, Ilić, Marija, Mitić, Bogdan, Đorđević, Brižita, Ivanović, Nevena, "Improving the viability and stability of a probiotic product with Saccharomyces boulardii DBVPG" in Hemijska industrija, 75, no. 1 (2021):25-30,
https://doi.org/10.2298/HEMIND201211008K . .