TY  - JOUR
AU  - Žuža, Olivera
AU  - Minić, Rajna
AU  - Kotur-Stevuljević, Jelena
AU  - Žujović, Dejan
AU  - Đorđević, Brižita
AU  - Ilić, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4090
AB  - OBJECTIVE: The aim of this study was to determine any differences in ox- idative stress and inflammation parameters in COPD patients treated with either N-acetyl cys- teine (NAC) alone or with NAC in combination with propolis (NACP). PATIENTS AND METHODS: Forty COPD pa- tients in the exacerbation phase were enrolled into the study and were treated with either NAC (NAC group; n=20) or NACP (NACP group; n=20) twice daily for one month. Redox status was de - termined by measuring superoxide anion (O 2 .– ), advanced oxidation protein products (AOPP), total oxidative status (TOS), prooxidative-anti- oxidant balance (PAB), malondialdehyde (MDA), ischemia modified albumin (IMA) and sever- al other antioxidant markers: superoxide dis- mutase (SOD), paraoxonase 1 (PON1), total sulf- hydryl groups (SHG) and total antioxidant status (TAS). Interleukins 6, 8 and 17 were measured as markers of inflammatory status. RESULTS: Both groups had similar socio-de - mographic and clinical characteristics. Af- ter treatment significantly higher SHG [0.446 (0.395-0.516) vs. 0.292 (0.270-0.325), p<0.001] and significantly lower TOS – 50.6 [49.7-53.4 vs. 73.2 (50.9-84.6), p<0.05] – and IMA [0.650 (0.629-0.682) vs. 0.709 (0.667-0.756), p<0.05] – were found in the NACP group compared to the NAC group. Factorial analysis indicated a larger oxidative stress-inflammatory load in the NAC group after treatment. CONCLUSIONS: From an oxidative stress and inflammatory status perspective, treatment with NACP was more successful than with NAC. The inclusion of propolis into therapy for COPD patients, especially those in the exacerbation phase, could prove beneficial.
PB  - Verduci Editore srl
T2  - European Review for Medical and Pharmacological Sciences
T1  - A combination of N-acetyl cysteine and propolis
attenuates oxidative-inflammatory parameters
during COPD exacerbation
VL  - 26
IS  - 7
SP  - 2467
EP  - 2477
DO  - 10.26355/eurrev_202204_28481
ER  - 

@article{
author = "Žuža, Olivera and Minić, Rajna and Kotur-Stevuljević, Jelena and Žujović, Dejan and Đorđević, Brižita and Ilić, Aleksandra",
year = "2022",
abstract = "OBJECTIVE: The aim of this study was to determine any differences in ox- idative stress and inflammation parameters in COPD patients treated with either N-acetyl cys- teine (NAC) alone or with NAC in combination with propolis (NACP). PATIENTS AND METHODS: Forty COPD pa- tients in the exacerbation phase were enrolled into the study and were treated with either NAC (NAC group; n=20) or NACP (NACP group; n=20) twice daily for one month. Redox status was de - termined by measuring superoxide anion (O 2 .– ), advanced oxidation protein products (AOPP), total oxidative status (TOS), prooxidative-anti- oxidant balance (PAB), malondialdehyde (MDA), ischemia modified albumin (IMA) and sever- al other antioxidant markers: superoxide dis- mutase (SOD), paraoxonase 1 (PON1), total sulf- hydryl groups (SHG) and total antioxidant status (TAS). Interleukins 6, 8 and 17 were measured as markers of inflammatory status. RESULTS: Both groups had similar socio-de - mographic and clinical characteristics. Af- ter treatment significantly higher SHG [0.446 (0.395-0.516) vs. 0.292 (0.270-0.325), p<0.001] and significantly lower TOS – 50.6 [49.7-53.4 vs. 73.2 (50.9-84.6), p<0.05] – and IMA [0.650 (0.629-0.682) vs. 0.709 (0.667-0.756), p<0.05] – were found in the NACP group compared to the NAC group. Factorial analysis indicated a larger oxidative stress-inflammatory load in the NAC group after treatment. CONCLUSIONS: From an oxidative stress and inflammatory status perspective, treatment with NACP was more successful than with NAC. The inclusion of propolis into therapy for COPD patients, especially those in the exacerbation phase, could prove beneficial.",
publisher = "Verduci Editore srl",
journal = "European Review for Medical and Pharmacological Sciences",
title = "A combination of N-acetyl cysteine and propolis
attenuates oxidative-inflammatory parameters
during COPD exacerbation",
volume = "26",
number = "7",
pages = "2467-2477",
doi = "10.26355/eurrev_202204_28481"
}

Žuža, O., Minić, R., Kotur-Stevuljević, J., Žujović, D., Đorđević, B.,& Ilić, A.. (2022). A combination of N-acetyl cysteine and propolis
attenuates oxidative-inflammatory parameters
during COPD exacerbation. in European Review for Medical and Pharmacological Sciences
Verduci Editore srl., 26(7), 2467-2477.
https://doi.org/10.26355/eurrev_202204_28481

Žuža O, Minić R, Kotur-Stevuljević J, Žujović D, Đorđević B, Ilić A. A combination of N-acetyl cysteine and propolis
attenuates oxidative-inflammatory parameters
during COPD exacerbation. in European Review for Medical and Pharmacological Sciences. 2022;26(7):2467-2477.
doi:10.26355/eurrev_202204_28481 .

Žuža, Olivera, Minić, Rajna, Kotur-Stevuljević, Jelena, Žujović, Dejan, Đorđević, Brižita, Ilić, Aleksandra, "A combination of N-acetyl cysteine and propolis
attenuates oxidative-inflammatory parameters
during COPD exacerbation" in European Review for Medical and Pharmacological Sciences, 26, no. 7 (2022):2467-2477,
https://doi.org/10.26355/eurrev_202204_28481 . .

TY  - CONF
AU  - Milenković, B.
AU  - Božić, I.
AU  - Kotur, Jelena
AU  - Stanojković, I.
AU  - Ilić, A.
AU  - Janković, J.
AU  - Cvok, T.
AU  - Mitić, J.
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1742
PB  - Springer Wien, Wien
C3  - Willdenowia
T1  - Osteoporosis in COPD patients
VL  - 124
IS  - 13-14
SP  - 484
EP  - 485
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1742
ER  - 

@conference{
author = "Milenković, B. and Božić, I. and Kotur, Jelena and Stanojković, I. and Ilić, A. and Janković, J. and Cvok, T. and Mitić, J.",
year = "2012",
publisher = "Springer Wien, Wien",
journal = "Willdenowia",
title = "Osteoporosis in COPD patients",
volume = "124",
number = "13-14",
pages = "484-485",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1742"
}

Milenković, B., Božić, I., Kotur, J., Stanojković, I., Ilić, A., Janković, J., Cvok, T.,& Mitić, J.. (2012). Osteoporosis in COPD patients. in Willdenowia
Springer Wien, Wien., 124(13-14), 484-485.
https://hdl.handle.net/21.15107/rcub_farfar_1742

Milenković B, Božić I, Kotur J, Stanojković I, Ilić A, Janković J, Cvok T, Mitić J. Osteoporosis in COPD patients. in Willdenowia. 2012;124(13-14):484-485.
https://hdl.handle.net/21.15107/rcub_farfar_1742 .

Milenković, B., Božić, I., Kotur, Jelena, Stanojković, I., Ilić, A., Janković, J., Cvok, T., Mitić, J., "Osteoporosis in COPD patients" in Willdenowia, 124, no. 13-14 (2012):484-485,
https://hdl.handle.net/21.15107/rcub_farfar_1742 .