TY  - JOUR
AU  - Popović-Nikolić, Marija
AU  - Čakar, Mira
AU  - Todorović, Nina
AU  - Nikolić, Katarina
AU  - Popović, Gordana
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5589
AB  - The acid–base equilibria of raloxifene and the mutual influence of pH and solubility enhancers on the solubility of raloxifene
hydrochloride were studied. The apparent ionization constants (pKa*) of raloxifene were determined potentiometrically in
methanol–water mixtures (45%-55% w/w), and the pKa values (pKa1 = 7.21 ± 0.02, pKa2 = 7.86 ± 0.02, pKa3 = 9.97 ± 0.04)
defining ionization in aqueous media were obtained by extrapolating the pKa* values to 0% of methanol. The obtained pKa
values were assigned to the corresponding ionization centers. Based on the ionization constants obtained in this study, the
distribution of the equilibrium forms of raloxifene was calculated. The solubility of raloxifene hydrochloride in 0.01 M
HCl, acetate buffer pH 4.5 and phosphate buffer pH 6.8 was studied with and without the presence of β-CD, HP-β-CD and
polysorbate 80. The most effective solubility enhancer of raloxifene hydrochloride in 0.01 M HCl was polysorbate 80 at a
concentration of 0.5%, while the influence of this enhancer in phosphate buffer pH 6.8 was negligible. The highest solubility
of raloxifene hydrochloride in acetate and phosphate buffer was achieved in the presence of 10–
3 M HP–β-CD which
was 1.3-fold higher in both 0.01 M HCl and acetate buffer and 2.3-fold higher in phosphate buffer than in the presence of
10–
3 M β-CD.
PB  - Springer Nature
T2  - Chemical Papers
T1  - Study on protolytic equilibria and the effects of pH, cyclodextrins and polysorbate 80 on solubility of raloxifene hydrochloride
DO  - 10.1007/s11696-024-03399-1
ER  - 

@article{
author = "Popović-Nikolić, Marija and Čakar, Mira and Todorović, Nina and Nikolić, Katarina and Popović, Gordana",
year = "2024",
abstract = "The acid–base equilibria of raloxifene and the mutual influence of pH and solubility enhancers on the solubility of raloxifene
hydrochloride were studied. The apparent ionization constants (pKa*) of raloxifene were determined potentiometrically in
methanol–water mixtures (45%-55% w/w), and the pKa values (pKa1 = 7.21 ± 0.02, pKa2 = 7.86 ± 0.02, pKa3 = 9.97 ± 0.04)
defining ionization in aqueous media were obtained by extrapolating the pKa* values to 0% of methanol. The obtained pKa
values were assigned to the corresponding ionization centers. Based on the ionization constants obtained in this study, the
distribution of the equilibrium forms of raloxifene was calculated. The solubility of raloxifene hydrochloride in 0.01 M
HCl, acetate buffer pH 4.5 and phosphate buffer pH 6.8 was studied with and without the presence of β-CD, HP-β-CD and
polysorbate 80. The most effective solubility enhancer of raloxifene hydrochloride in 0.01 M HCl was polysorbate 80 at a
concentration of 0.5%, while the influence of this enhancer in phosphate buffer pH 6.8 was negligible. The highest solubility
of raloxifene hydrochloride in acetate and phosphate buffer was achieved in the presence of 10–
3 M HP–β-CD which
was 1.3-fold higher in both 0.01 M HCl and acetate buffer and 2.3-fold higher in phosphate buffer than in the presence of
10–
3 M β-CD.",
publisher = "Springer Nature",
journal = "Chemical Papers",
title = "Study on protolytic equilibria and the effects of pH, cyclodextrins and polysorbate 80 on solubility of raloxifene hydrochloride",
doi = "10.1007/s11696-024-03399-1"
}

Popović-Nikolić, M., Čakar, M., Todorović, N., Nikolić, K.,& Popović, G.. (2024). Study on protolytic equilibria and the effects of pH, cyclodextrins and polysorbate 80 on solubility of raloxifene hydrochloride. in Chemical Papers
Springer Nature..
https://doi.org/10.1007/s11696-024-03399-1

Popović-Nikolić M, Čakar M, Todorović N, Nikolić K, Popović G. Study on protolytic equilibria and the effects of pH, cyclodextrins and polysorbate 80 on solubility of raloxifene hydrochloride. in Chemical Papers. 2024;.
doi:10.1007/s11696-024-03399-1 .

Popović-Nikolić, Marija, Čakar, Mira, Todorović, Nina, Nikolić, Katarina, Popović, Gordana, "Study on protolytic equilibria and the effects of pH, cyclodextrins and polysorbate 80 on solubility of raloxifene hydrochloride" in Chemical Papers (2024),
https://doi.org/10.1007/s11696-024-03399-1 . .

TY  - CONF
AU  - Popović-Nikolić, Marija
AU  - Čakar, Mira
AU  - Popović, Gordana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4682
AB  - The apparent ionization constants (pKa*) of raloxifene have been determined potentiometrically in methanol water mixtures (45% - 55% wt/wt) and the pKa values (pKa1=7.21±0.02, pKa2=7.86±0.02, pKa3=9.97±0.04) which define the ionization in aqueous media were obtained by extrapolation of the pKa* values to 0% of methanol. Obtained pKa values were assigned to corresponding ionization centers. On the basis of the ionization constants determined in this study distribution of raloxifene equilibrium forms have been calculated.
PB  - Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
T1  - The protolytic equilibria of raloxifene
VL  - II
SP  - 581
EP  - 584
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4682
ER  - 

@conference{
author = "Popović-Nikolić, Marija and Čakar, Mira and Popović, Gordana",
year = "2022",
abstract = "The apparent ionization constants (pKa*) of raloxifene have been determined potentiometrically in methanol water mixtures (45% - 55% wt/wt) and the pKa values (pKa1=7.21±0.02, pKa2=7.86±0.02, pKa3=9.97±0.04) which define the ionization in aqueous media were obtained by extrapolation of the pKa* values to 0% of methanol. Obtained pKa values were assigned to corresponding ionization centers. On the basis of the ionization constants determined in this study distribution of raloxifene equilibrium forms have been calculated.",
publisher = "Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)",
title = "The protolytic equilibria of raloxifene",
volume = "II",
pages = "581-584",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4682"
}

Popović-Nikolić, M., Čakar, M.,& Popović, G.. (2022). The protolytic equilibria of raloxifene. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
Society of Physical Chemists of Serbia., II, 581-584.
https://hdl.handle.net/21.15107/rcub_farfar_4682

Popović-Nikolić M, Čakar M, Popović G. The protolytic equilibria of raloxifene. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings). 2022;II:581-584.
https://hdl.handle.net/21.15107/rcub_farfar_4682 .

Popović-Nikolić, Marija, Čakar, Mira, Popović, Gordana, "The protolytic equilibria of raloxifene" in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings), II (2022):581-584,
https://hdl.handle.net/21.15107/rcub_farfar_4682 .

TY  - CONF
AU  - Čakar, Uroš
AU  - Grozdanić, Nađa
AU  - Lisov, Nikolina
AU  - Petrović, Aleksandar
AU  - Čakar, Mira
AU  - Vajs, Vlatka
AU  - Đorđević, Brižita
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5390
AB  - Peach is fruit which is possible to find in different foods due to it nutritional value and nice
fresh flavor. Derived products from peach are also important. One of such derived product is wine
which possess possible beneficial health properties. ...
PB  - International Pharmaceutical Federation (FIP)
C3  - FIP Virtual 2020, 4 – 25 September 2020, "Living and learning through the
Covid-19 pandemic– Global reflections"
T1  - Stone fruit wine-potential functional food
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5390
ER  - 

@conference{
author = "Čakar, Uroš and Grozdanić, Nađa and Lisov, Nikolina and Petrović, Aleksandar and Čakar, Mira and Vajs, Vlatka and Đorđević, Brižita",
year = "2020",
abstract = "Peach is fruit which is possible to find in different foods due to it nutritional value and nice
fresh flavor. Derived products from peach are also important. One of such derived product is wine
which possess possible beneficial health properties. ...",
publisher = "International Pharmaceutical Federation (FIP)",
journal = "FIP Virtual 2020, 4 – 25 September 2020, "Living and learning through the
Covid-19 pandemic– Global reflections"",
title = "Stone fruit wine-potential functional food",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5390"
}

Čakar, U., Grozdanić, N., Lisov, N., Petrović, A., Čakar, M., Vajs, V.,& Đorđević, B.. (2020). Stone fruit wine-potential functional food. in FIP Virtual 2020, 4 – 25 September 2020, "Living and learning through the
Covid-19 pandemic– Global reflections"
International Pharmaceutical Federation (FIP)..
https://hdl.handle.net/21.15107/rcub_farfar_5390

Čakar U, Grozdanić N, Lisov N, Petrović A, Čakar M, Vajs V, Đorđević B. Stone fruit wine-potential functional food. in FIP Virtual 2020, 4 – 25 September 2020, "Living and learning through the
Covid-19 pandemic– Global reflections". 2020;.
https://hdl.handle.net/21.15107/rcub_farfar_5390 .

Čakar, Uroš, Grozdanić, Nađa, Lisov, Nikolina, Petrović, Aleksandar, Čakar, Mira, Vajs, Vlatka, Đorđević, Brižita, "Stone fruit wine-potential functional food" in FIP Virtual 2020, 4 – 25 September 2020, "Living and learning through the
Covid-19 pandemic– Global reflections" (2020),
https://hdl.handle.net/21.15107/rcub_farfar_5390 .

TY  - JOUR
AU  - Čakar, Uroš
AU  - Petrović, Aleksandar V.
AU  - Pejin, Boris
AU  - Čakar, Mira
AU  - Živković, Marijana
AU  - Vajs, Vlatka
AU  - Đorđević, Brižita
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3320
AB  - This study aimed to estimate the potential of the selected berry (strawberry) and drupe (apricot, plum and sweet cherry) fruits as the substrates for the production of new fruit wines enriched with phenolic compounds. Sweet cherry wine (cultivar Burlat) stood out both for the profound content of phenolics (followed by their chemical profile) and potent anti-DPPH radical activity. The same fruit wine samples exhibited high redox potentials, slightly lower than strawberry and plum wine samples. Therefore, sweet cherry cultivar Burlat may be well recommended for development of novel fruit-based products endowed with naturally occurring phenolics. In any case, the remaining four cultivars are also worth further research efforts, particularly apricot cultivar Keckemetska ruza, which is one of the representatives of greatly underestimated fruit type thus far as a substrate for the production of the relevant fruit wines.
PB  - Elsevier Science BV, Amsterdam
T2  - Scientific Reports
T1  - Fruit as a substrate for a wine: A case study of selected berry and drupe fruit wines
VL  - 244
SP  - 42
EP  - 49
DO  - 10.1016/j.scienta.2018.09.020
ER  - 

@article{
author = "Čakar, Uroš and Petrović, Aleksandar V. and Pejin, Boris and Čakar, Mira and Živković, Marijana and Vajs, Vlatka and Đorđević, Brižita",
year = "2019",
abstract = "This study aimed to estimate the potential of the selected berry (strawberry) and drupe (apricot, plum and sweet cherry) fruits as the substrates for the production of new fruit wines enriched with phenolic compounds. Sweet cherry wine (cultivar Burlat) stood out both for the profound content of phenolics (followed by their chemical profile) and potent anti-DPPH radical activity. The same fruit wine samples exhibited high redox potentials, slightly lower than strawberry and plum wine samples. Therefore, sweet cherry cultivar Burlat may be well recommended for development of novel fruit-based products endowed with naturally occurring phenolics. In any case, the remaining four cultivars are also worth further research efforts, particularly apricot cultivar Keckemetska ruza, which is one of the representatives of greatly underestimated fruit type thus far as a substrate for the production of the relevant fruit wines.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Scientific Reports",
title = "Fruit as a substrate for a wine: A case study of selected berry and drupe fruit wines",
volume = "244",
pages = "42-49",
doi = "10.1016/j.scienta.2018.09.020"
}

Čakar, U., Petrović, A. V., Pejin, B., Čakar, M., Živković, M., Vajs, V.,& Đorđević, B.. (2019). Fruit as a substrate for a wine: A case study of selected berry and drupe fruit wines. in Scientific Reports
Elsevier Science BV, Amsterdam., 244, 42-49.
https://doi.org/10.1016/j.scienta.2018.09.020

Čakar U, Petrović AV, Pejin B, Čakar M, Živković M, Vajs V, Đorđević B. Fruit as a substrate for a wine: A case study of selected berry and drupe fruit wines. in Scientific Reports. 2019;244:42-49.
doi:10.1016/j.scienta.2018.09.020 .

Čakar, Uroš, Petrović, Aleksandar V., Pejin, Boris, Čakar, Mira, Živković, Marijana, Vajs, Vlatka, Đorđević, Brižita, "Fruit as a substrate for a wine: A case study of selected berry and drupe fruit wines" in Scientific Reports, 244 (2019):42-49,
https://doi.org/10.1016/j.scienta.2018.09.020 . .

TY  - JOUR
AU  - Čakar, Uroš
AU  - Grozdanić, Nada
AU  - Pejin, Boris
AU  - Vasić, Vesna
AU  - Čakar, Mira
AU  - Petrović, Aleksandar V.
AU  - Đorđević, Brižita
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3081
AB  - alpha-Glucosidase inhibitory activity (AGL) of fruit wine samples made from blueberry, black chokeberry, blackberry, raspberry and sour cherry cultivars grown in Serbia was studied using an microvinification procedure. More precisely, both sugar and enzyme were added to the fruit must before fermentation for half of the samples. This increased the extraction of phenolic compounds. All the samples showed higher bioactivity compared to acarbose, the compound used as a positive control. Blueberry (IC50 similar to 27 +/- 1 mu g/ml) and black chokeberry (IC50 similar to 28 +/- 1 mu g/ml) wine samples had the highest values regardless of the vinification method. In addition to this, chlorogenic and caffeic acids were recognised as their key AGL bioactives. Taken all together, the fruit wine samples or their lyophilised extracts may be considered as complementary medicine supplements of potential interest for the control of postprandial hyperglycemia.
PB  - Elsevier Science BV, Amsterdam
T2  - Food Bioscience
T1  - Impact of vinification procedure on fruit wine inhibitory activity against alpha-glucosidase
VL  - 25
SP  - 1
EP  - 7
DO  - 10.1016/j.fbio.2018.06.009
ER  - 

@article{
author = "Čakar, Uroš and Grozdanić, Nada and Pejin, Boris and Vasić, Vesna and Čakar, Mira and Petrović, Aleksandar V. and Đorđević, Brižita",
year = "2018",
abstract = "alpha-Glucosidase inhibitory activity (AGL) of fruit wine samples made from blueberry, black chokeberry, blackberry, raspberry and sour cherry cultivars grown in Serbia was studied using an microvinification procedure. More precisely, both sugar and enzyme were added to the fruit must before fermentation for half of the samples. This increased the extraction of phenolic compounds. All the samples showed higher bioactivity compared to acarbose, the compound used as a positive control. Blueberry (IC50 similar to 27 +/- 1 mu g/ml) and black chokeberry (IC50 similar to 28 +/- 1 mu g/ml) wine samples had the highest values regardless of the vinification method. In addition to this, chlorogenic and caffeic acids were recognised as their key AGL bioactives. Taken all together, the fruit wine samples or their lyophilised extracts may be considered as complementary medicine supplements of potential interest for the control of postprandial hyperglycemia.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Food Bioscience",
title = "Impact of vinification procedure on fruit wine inhibitory activity against alpha-glucosidase",
volume = "25",
pages = "1-7",
doi = "10.1016/j.fbio.2018.06.009"
}

Čakar, U., Grozdanić, N., Pejin, B., Vasić, V., Čakar, M., Petrović, A. V.,& Đorđević, B.. (2018). Impact of vinification procedure on fruit wine inhibitory activity against alpha-glucosidase. in Food Bioscience
Elsevier Science BV, Amsterdam., 25, 1-7.
https://doi.org/10.1016/j.fbio.2018.06.009

Čakar U, Grozdanić N, Pejin B, Vasić V, Čakar M, Petrović AV, Đorđević B. Impact of vinification procedure on fruit wine inhibitory activity against alpha-glucosidase. in Food Bioscience. 2018;25:1-7.
doi:10.1016/j.fbio.2018.06.009 .

Čakar, Uroš, Grozdanić, Nada, Pejin, Boris, Vasić, Vesna, Čakar, Mira, Petrović, Aleksandar V., Đorđević, Brižita, "Impact of vinification procedure on fruit wine inhibitory activity against alpha-glucosidase" in Food Bioscience, 25 (2018):1-7,
https://doi.org/10.1016/j.fbio.2018.06.009 . .

TY  - JOUR
AU  - Čakar, Uroš
AU  - Petrović, Aleksandra
AU  - Janković, M.
AU  - Pejin, Boris
AU  - Vajs, Vlatka
AU  - Čakar, Mira
AU  - Đorđević, Brižita
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3173
AB  - Introduction - Fruit and their products, including fruit wines, represent a rich source of natural bioactive compounds. This study focusing on fruit wines (prepared from commercially grown fruits by Serbian producers) has included the investigation of their chemical composition and biological activity. Materials and methods - Black chokeberry, blueberry, raspberry, blackberry and cherry were used for wine production by innovative vinification procedure, with or without using sugar and enzymatic preparation glycosidase, respectively. Selected phenolics were identified and quantified by UPLC/MS-MS analysis, while Total Phenolic Content (TPC) was determined by the Folin-Ciocalteu method. In addition to this, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and FRAP (Ferric Reducing Ability of Plasma) methods were applied for the preliminary evaluation of anti-DPPH radical activity and redox potential respectively at in vitro conditions. Results and discussion - Among the fruit wines examined within this study, the blackberry one stood out for profound FRAP (115.23 mmol L-1 Fe2+), DPPH (1.11%) and TPC values (2,395 mg GAE L-1). On the other hand, the raspberry wine showed the lowest potential towards the aforementioned parameters. Using principal component analysis, these fruit wines were chemically differentiated, according to the predominant phenolic compounds. Conclusions - All fruit wine samples displayed a good antioxidant potential with the blackberry one being most potent. Such a finding is of particular importance for Serbia as one of the leading producers of this edible fruit both in Europe and rest of the world.
PB  - Int Soc Horticultural Science-Ishs, Leuven
T2  - European Journal of Horticultural Science
T1  - Differentiation of wines made from berry and drupe fruits according to their phenolic profiles
VL  - 83
IS  - 1
SP  - 49
EP  - 61
DO  - 10.17660/eJHS.2018/83.1.7
ER  - 

@article{
author = "Čakar, Uroš and Petrović, Aleksandra and Janković, M. and Pejin, Boris and Vajs, Vlatka and Čakar, Mira and Đorđević, Brižita",
year = "2018",
abstract = "Introduction - Fruit and their products, including fruit wines, represent a rich source of natural bioactive compounds. This study focusing on fruit wines (prepared from commercially grown fruits by Serbian producers) has included the investigation of their chemical composition and biological activity. Materials and methods - Black chokeberry, blueberry, raspberry, blackberry and cherry were used for wine production by innovative vinification procedure, with or without using sugar and enzymatic preparation glycosidase, respectively. Selected phenolics were identified and quantified by UPLC/MS-MS analysis, while Total Phenolic Content (TPC) was determined by the Folin-Ciocalteu method. In addition to this, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and FRAP (Ferric Reducing Ability of Plasma) methods were applied for the preliminary evaluation of anti-DPPH radical activity and redox potential respectively at in vitro conditions. Results and discussion - Among the fruit wines examined within this study, the blackberry one stood out for profound FRAP (115.23 mmol L-1 Fe2+), DPPH (1.11%) and TPC values (2,395 mg GAE L-1). On the other hand, the raspberry wine showed the lowest potential towards the aforementioned parameters. Using principal component analysis, these fruit wines were chemically differentiated, according to the predominant phenolic compounds. Conclusions - All fruit wine samples displayed a good antioxidant potential with the blackberry one being most potent. Such a finding is of particular importance for Serbia as one of the leading producers of this edible fruit both in Europe and rest of the world.",
publisher = "Int Soc Horticultural Science-Ishs, Leuven",
journal = "European Journal of Horticultural Science",
title = "Differentiation of wines made from berry and drupe fruits according to their phenolic profiles",
volume = "83",
number = "1",
pages = "49-61",
doi = "10.17660/eJHS.2018/83.1.7"
}

Čakar, U., Petrović, A., Janković, M., Pejin, B., Vajs, V., Čakar, M.,& Đorđević, B.. (2018). Differentiation of wines made from berry and drupe fruits according to their phenolic profiles. in European Journal of Horticultural Science
Int Soc Horticultural Science-Ishs, Leuven., 83(1), 49-61.
https://doi.org/10.17660/eJHS.2018/83.1.7

Čakar U, Petrović A, Janković M, Pejin B, Vajs V, Čakar M, Đorđević B. Differentiation of wines made from berry and drupe fruits according to their phenolic profiles. in European Journal of Horticultural Science. 2018;83(1):49-61.
doi:10.17660/eJHS.2018/83.1.7 .

Čakar, Uroš, Petrović, Aleksandra, Janković, M., Pejin, Boris, Vajs, Vlatka, Čakar, Mira, Đorđević, Brižita, "Differentiation of wines made from berry and drupe fruits according to their phenolic profiles" in European Journal of Horticultural Science, 83, no. 1 (2018):49-61,
https://doi.org/10.17660/eJHS.2018/83.1.7 . .

TY  - JOUR
AU  - Čakar, Mira
AU  - Popović, Gordana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1822
AB  - A kinetic spectrophotometric method for determination of lisinopril in pharmaceuticals has been developed. The method is based on the activator action of lisinopril on Cu(II) ions catalysing the oxidation of Nile Blue A with hydrogen peroxide in borate buffer (pH 9.3). A decrease of the absorbance was recorded at 635 nm after 5 min at 25 °C. Linearity was established by application of the tangent method within the concentration range of lisinopril from 0.8-6.4 μg mL-1, the detection and quantification limits being 0.158 and 0.480 μg mL-1, respectively. The method was successfully applied to three brands of tablets containing lisinopril alone or in combination with hydrochlorothiazide.
AB  - Razvijena je kinetička spektrofotometrijska metoda za određivanje lizinoprila u farmaceutskim preparatima. Metoda se zasniva na aktivatorskom dejstvu lizinoprila na reakciju oksidacije boje nil plavog-A vodonik-peroksidom u boratnom puferu (pH 9,3), a koja je katalizovana Cu(II) jonima. Smanjenje apsorbancije mereno je na 635 nm u vremenskom periodu od 5 min na temperaturi 25°C. Linearnost je utvrđena primenom metode tangensa u opsegu koncentracija lizinoprila 0,8-6,4 μg mL-1, sa limitom detekcije 0,158 μg mL-1 i limitom određivanja 0,480 μg mL-1. Metoda je primenjena za analizu tri komercijalna preparata koja su sadržala lizinopril i lizinopril u kombinaciji sa hidrohlortiazidom.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Determination of lisinopril in pharmaceuticals by a kinetic spectrophotometric method
T1  - Određivanje lizinoprila u farmaceutskim preparatima primenom kinetičke spektrofotometrijske metode
VL  - 77
IS  - 10
SP  - 1437
EP  - 1442
DO  - 10.2298/JSC120131079C
ER  - 

@article{
author = "Čakar, Mira and Popović, Gordana",
year = "2012",
abstract = "A kinetic spectrophotometric method for determination of lisinopril in pharmaceuticals has been developed. The method is based on the activator action of lisinopril on Cu(II) ions catalysing the oxidation of Nile Blue A with hydrogen peroxide in borate buffer (pH 9.3). A decrease of the absorbance was recorded at 635 nm after 5 min at 25 °C. Linearity was established by application of the tangent method within the concentration range of lisinopril from 0.8-6.4 μg mL-1, the detection and quantification limits being 0.158 and 0.480 μg mL-1, respectively. The method was successfully applied to three brands of tablets containing lisinopril alone or in combination with hydrochlorothiazide., Razvijena je kinetička spektrofotometrijska metoda za određivanje lizinoprila u farmaceutskim preparatima. Metoda se zasniva na aktivatorskom dejstvu lizinoprila na reakciju oksidacije boje nil plavog-A vodonik-peroksidom u boratnom puferu (pH 9,3), a koja je katalizovana Cu(II) jonima. Smanjenje apsorbancije mereno je na 635 nm u vremenskom periodu od 5 min na temperaturi 25°C. Linearnost je utvrđena primenom metode tangensa u opsegu koncentracija lizinoprila 0,8-6,4 μg mL-1, sa limitom detekcije 0,158 μg mL-1 i limitom određivanja 0,480 μg mL-1. Metoda je primenjena za analizu tri komercijalna preparata koja su sadržala lizinopril i lizinopril u kombinaciji sa hidrohlortiazidom.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Determination of lisinopril in pharmaceuticals by a kinetic spectrophotometric method, Određivanje lizinoprila u farmaceutskim preparatima primenom kinetičke spektrofotometrijske metode",
volume = "77",
number = "10",
pages = "1437-1442",
doi = "10.2298/JSC120131079C"
}

Čakar, M.,& Popović, G.. (2012). Determination of lisinopril in pharmaceuticals by a kinetic spectrophotometric method. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 77(10), 1437-1442.
https://doi.org/10.2298/JSC120131079C

Čakar M, Popović G. Determination of lisinopril in pharmaceuticals by a kinetic spectrophotometric method. in Journal of the Serbian Chemical Society. 2012;77(10):1437-1442.
doi:10.2298/JSC120131079C .

Čakar, Mira, Popović, Gordana, "Determination of lisinopril in pharmaceuticals by a kinetic spectrophotometric method" in Journal of the Serbian Chemical Society, 77, no. 10 (2012):1437-1442,
https://doi.org/10.2298/JSC120131079C . .

TY  - JOUR
AU  - Popović, Gordana
AU  - Čakar, Mira
AU  - Agbaba, Danica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1234
AB  - Acid-base equilibria in homogeneous and heterogeneous systems of two antihistaminics, loratadine and desloratadine were studied spectrophotometrically in Britton-Robinson's buffer at 25 degrees C. Acidity constant of loratadine was found to be pK(a) 5.25 and those of desloratadine pK(a1) 4.41 and pK(a2) 9.97. The values of intrinsic solubilities of loratadine and desloratadine were 8.65 x 10(-6) M and 3.82 x 10(-4) M, respectively. Based on the pK(a) values and intrinsic solubilities, solubility curves of these two drugs as a function of pH were calculated. The effects of anionic, cationic and non-ionic surfactants applied in the concentration exceeding critical micelle concentration (cmc) on acid-base properties of loratadine and desloratadine, as well as on intrinsic solubility of loratadine were also examined. The results revealed a shift of pK(a) values in micellar media comparing to the values obtained in water. These shifts (Delta pK(a)) ranged from -2.24 to +1.24.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Acid-base equilibria and solubility of loratadine and desloratadine in water and micellar media
VL  - 49
IS  - 1
SP  - 42
EP  - 47
DO  - 10.1016/j.jpba.2008.09.043
ER  - 

@article{
author = "Popović, Gordana and Čakar, Mira and Agbaba, Danica",
year = "2009",
abstract = "Acid-base equilibria in homogeneous and heterogeneous systems of two antihistaminics, loratadine and desloratadine were studied spectrophotometrically in Britton-Robinson's buffer at 25 degrees C. Acidity constant of loratadine was found to be pK(a) 5.25 and those of desloratadine pK(a1) 4.41 and pK(a2) 9.97. The values of intrinsic solubilities of loratadine and desloratadine were 8.65 x 10(-6) M and 3.82 x 10(-4) M, respectively. Based on the pK(a) values and intrinsic solubilities, solubility curves of these two drugs as a function of pH were calculated. The effects of anionic, cationic and non-ionic surfactants applied in the concentration exceeding critical micelle concentration (cmc) on acid-base properties of loratadine and desloratadine, as well as on intrinsic solubility of loratadine were also examined. The results revealed a shift of pK(a) values in micellar media comparing to the values obtained in water. These shifts (Delta pK(a)) ranged from -2.24 to +1.24.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Acid-base equilibria and solubility of loratadine and desloratadine in water and micellar media",
volume = "49",
number = "1",
pages = "42-47",
doi = "10.1016/j.jpba.2008.09.043"
}

Popović, G., Čakar, M.,& Agbaba, D.. (2009). Acid-base equilibria and solubility of loratadine and desloratadine in water and micellar media. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 49(1), 42-47.
https://doi.org/10.1016/j.jpba.2008.09.043

Popović G, Čakar M, Agbaba D. Acid-base equilibria and solubility of loratadine and desloratadine in water and micellar media. in Journal of Pharmaceutical and Biomedical Analysis. 2009;49(1):42-47.
doi:10.1016/j.jpba.2008.09.043 .

Popović, Gordana, Čakar, Mira, Agbaba, Danica, "Acid-base equilibria and solubility of loratadine and desloratadine in water and micellar media" in Journal of Pharmaceutical and Biomedical Analysis, 49, no. 1 (2009):42-47,
https://doi.org/10.1016/j.jpba.2008.09.043 . .

TY  - JOUR
AU  - Korićanac, Zagorka
AU  - Čakar, Mira
AU  - Tanasković, Slađana
AU  - Jovanović, Tatijana
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1003
AB  - A spectrophotometric method is described for the assay of thioctic acid. The method is based on the reaction between the drug and palladium(II) chloride. In this reaction, a yellow-colored, water soluble product with a 1:1 stoichiometric ratio and an absorption maximum at 365 nm was formed. The stability of the formed complex depends on various factors (pH, reaction time, concentration of reagents, ionic strength). Based on these findings, a new method is suggested for the spectrophotometric determination of thioctic acid in pharmaceutical formulations. This method is simple, sensitive and reproducible.
AB  - Opisana je jednostavna spektrofotometrijska metoda za brzo i tačno određivanje tioktinske kiseline u vodi, injekcionim rastvorima i tabletama. Spektrofotometrijska merenja su izvođena u Britton-Robinson-ovim puferima pri različitim pH vrednostima (2,00-6,00) i konstantnoj jonskoj sili. Sastav, konstanta stabilnosti, molarna apsorptivnost kompleksa su određene različitim metodama. Utvrđen je 1:1 sastav nagrađenog kompleksa i molarna apsorptivnost 4.2x103 l mol-1 cm-1. Relativna standardna devijacija iznosi od 3,10 do 3,76%,{to odgovara propisanim analitičkim standardima.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Spectrophotometric determination of thioctic (α-lipoic) acid in water and pharmaceutical preparations
T1  - Spektrofotometrijsko određivanje tioktinske kiseline u vodi i farmaceutskim preparatima
VL  - 72
IS  - 1
SP  - 29
EP  - 35
DO  - 10.2298/JSC0701029K
ER  - 

@article{
author = "Korićanac, Zagorka and Čakar, Mira and Tanasković, Slađana and Jovanović, Tatijana",
year = "2007",
abstract = "A spectrophotometric method is described for the assay of thioctic acid. The method is based on the reaction between the drug and palladium(II) chloride. In this reaction, a yellow-colored, water soluble product with a 1:1 stoichiometric ratio and an absorption maximum at 365 nm was formed. The stability of the formed complex depends on various factors (pH, reaction time, concentration of reagents, ionic strength). Based on these findings, a new method is suggested for the spectrophotometric determination of thioctic acid in pharmaceutical formulations. This method is simple, sensitive and reproducible., Opisana je jednostavna spektrofotometrijska metoda za brzo i tačno određivanje tioktinske kiseline u vodi, injekcionim rastvorima i tabletama. Spektrofotometrijska merenja su izvođena u Britton-Robinson-ovim puferima pri različitim pH vrednostima (2,00-6,00) i konstantnoj jonskoj sili. Sastav, konstanta stabilnosti, molarna apsorptivnost kompleksa su određene različitim metodama. Utvrđen je 1:1 sastav nagrađenog kompleksa i molarna apsorptivnost 4.2x103 l mol-1 cm-1. Relativna standardna devijacija iznosi od 3,10 do 3,76%,{to odgovara propisanim analitičkim standardima.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Spectrophotometric determination of thioctic (α-lipoic) acid in water and pharmaceutical preparations, Spektrofotometrijsko određivanje tioktinske kiseline u vodi i farmaceutskim preparatima",
volume = "72",
number = "1",
pages = "29-35",
doi = "10.2298/JSC0701029K"
}

Korićanac, Z., Čakar, M., Tanasković, S.,& Jovanović, T.. (2007). Spectrophotometric determination of thioctic (α-lipoic) acid in water and pharmaceutical preparations. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 72(1), 29-35.
https://doi.org/10.2298/JSC0701029K

Korićanac Z, Čakar M, Tanasković S, Jovanović T. Spectrophotometric determination of thioctic (α-lipoic) acid in water and pharmaceutical preparations. in Journal of the Serbian Chemical Society. 2007;72(1):29-35.
doi:10.2298/JSC0701029K .

Korićanac, Zagorka, Čakar, Mira, Tanasković, Slađana, Jovanović, Tatijana, "Spectrophotometric determination of thioctic (α-lipoic) acid in water and pharmaceutical preparations" in Journal of the Serbian Chemical Society, 72, no. 1 (2007):29-35,
https://doi.org/10.2298/JSC0701029K . .

TY  - JOUR
AU  - Popović, Gordana
AU  - Čakar, Mira
AU  - Agbaba, Danica
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/905
AB  - Simple, rapid, and precise densitometric TLC methods have been established for simultaneous determination of loratadine and preservatives in loratadine-sodium benzoate and loratadine-methylparaben-propylparaben mixtures. Chromatography was performed on aluminium plates precoated with silica gel 60 F-254. The mobile phases were n-butyl acetate-carbon tetrachloride-acetic acid-acetonitrile 3:6:0.2:3 (v/v) for loratadine-sodium benzoate mixtures and ethyl acetate-n-hexane-methanol-ammonia-diethylamine 1:4:0.8:0.4:2 (v/v) for loratadine-methylparaben-propylparaben mixtures. Chromatographic zones were scanned in reflectance-absorbance mode at 240 nm for the former mixture and 275 mu for the latter. Relationships between peak areas and amounts of the compounds were evaluated by linear regression analysis in the concentration ranges 0.3-0.7 mu g per band for loratadine, methylparaben, and sodium benzoate and 0.03-0.07 mu g per band for propylparaben. Mean recovery for all the compounds varied from 98.3 to 102.5 %. Detection and quantification limits ranged from 0.004 to 0.03 and from 0.01 to 0.1 mu g per band, respectively. The proposed method was used for simultaneous determination of loratadine. and the preservatives in commercial medicinal syrups.
PB  - Univ Silesia, Inst Chemistry, Katowice
T2  - Acta Chromatographica
T1  - Simultaneous determination of loratadine and preservatives in syrups by thin-layer chromatography
VL  - 19
SP  - 161
EP  - 169
UR  - https://hdl.handle.net/21.15107/rcub_farfar_905
ER  - 

@article{
author = "Popović, Gordana and Čakar, Mira and Agbaba, Danica",
year = "2007",
abstract = "Simple, rapid, and precise densitometric TLC methods have been established for simultaneous determination of loratadine and preservatives in loratadine-sodium benzoate and loratadine-methylparaben-propylparaben mixtures. Chromatography was performed on aluminium plates precoated with silica gel 60 F-254. The mobile phases were n-butyl acetate-carbon tetrachloride-acetic acid-acetonitrile 3:6:0.2:3 (v/v) for loratadine-sodium benzoate mixtures and ethyl acetate-n-hexane-methanol-ammonia-diethylamine 1:4:0.8:0.4:2 (v/v) for loratadine-methylparaben-propylparaben mixtures. Chromatographic zones were scanned in reflectance-absorbance mode at 240 nm for the former mixture and 275 mu for the latter. Relationships between peak areas and amounts of the compounds were evaluated by linear regression analysis in the concentration ranges 0.3-0.7 mu g per band for loratadine, methylparaben, and sodium benzoate and 0.03-0.07 mu g per band for propylparaben. Mean recovery for all the compounds varied from 98.3 to 102.5 %. Detection and quantification limits ranged from 0.004 to 0.03 and from 0.01 to 0.1 mu g per band, respectively. The proposed method was used for simultaneous determination of loratadine. and the preservatives in commercial medicinal syrups.",
publisher = "Univ Silesia, Inst Chemistry, Katowice",
journal = "Acta Chromatographica",
title = "Simultaneous determination of loratadine and preservatives in syrups by thin-layer chromatography",
volume = "19",
pages = "161-169",
url = "https://hdl.handle.net/21.15107/rcub_farfar_905"
}

Popović, G., Čakar, M.,& Agbaba, D.. (2007). Simultaneous determination of loratadine and preservatives in syrups by thin-layer chromatography. in Acta Chromatographica
Univ Silesia, Inst Chemistry, Katowice., 19, 161-169.
https://hdl.handle.net/21.15107/rcub_farfar_905

Popović G, Čakar M, Agbaba D. Simultaneous determination of loratadine and preservatives in syrups by thin-layer chromatography. in Acta Chromatographica. 2007;19:161-169.
https://hdl.handle.net/21.15107/rcub_farfar_905 .

Popović, Gordana, Čakar, Mira, Agbaba, Danica, "Simultaneous determination of loratadine and preservatives in syrups by thin-layer chromatography" in Acta Chromatographica, 19 (2007):161-169,
https://hdl.handle.net/21.15107/rcub_farfar_905 .

TY  - CONF
AU  - Čakar, Mira
AU  - Popović, Gordana
AU  - Agbaba, Danica
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/759
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - HPTLC determination of loratadine in Claritine® tablets
T1  - HPTLC određivanje loratadina u Claritine® tabletama
VL  - 56
IS  - 5
SP  - 732
EP  - 733
UR  - https://hdl.handle.net/21.15107/rcub_farfar_759
ER  - 

@conference{
author = "Čakar, Mira and Popović, Gordana and Agbaba, Danica",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "HPTLC determination of loratadine in Claritine® tablets, HPTLC određivanje loratadina u Claritine® tabletama",
volume = "56",
number = "5",
pages = "732-733",
url = "https://hdl.handle.net/21.15107/rcub_farfar_759"
}

Čakar, M., Popović, G.,& Agbaba, D.. (2006). HPTLC determination of loratadine in Claritine® tablets. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(5), 732-733.
https://hdl.handle.net/21.15107/rcub_farfar_759

Čakar M, Popović G, Agbaba D. HPTLC determination of loratadine in Claritine® tablets. in Arhiv za farmaciju. 2006;56(5):732-733.
https://hdl.handle.net/21.15107/rcub_farfar_759 .

Čakar, Mira, Popović, Gordana, Agbaba, Danica, "HPTLC determination of loratadine in Claritine® tablets" in Arhiv za farmaciju, 56, no. 5 (2006):732-733,
https://hdl.handle.net/21.15107/rcub_farfar_759 .

TY  - JOUR
AU  - Čakar, Mira
AU  - Popović, Gordana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/879
AB  - A simple, accurate and selective high performance thin layer chromatographic method for the determination of saccharin in pharmaceuticals has been developed. The chromatography was performed on silica-gel 60F254 plates with ethyl acetate-carbon tetrachloride-acetic acid (3 + 4 + 0.5 v/v/v) as the mobile phase. The chromatographic zones corresponding to the saccharin spots were scanned in the reflectance/absorbance mode at λ=230 mm. For the standard curves, two series of saccharin sodium salt solutions were prepared: in methanol (solvent 1) and in ethyl acetate-acetic acid (9:1, v/v) mixture (solvent 2). A linear calibration relationship was observed within the concentration range from 300-1200 ng saccharin sodium salt per spot correlation coefficients being 0.998 (solvent 1) and 0.995 (solvent 2). The relationship between the peak area and the amount of saccharin sodium salt was evaluated by linear regression analysis. The limits of detection and quantification of saccharin sodium salt were 35 ng and 110 ng per spot (solvent 1), respectively, and 45 ng and 150 ng per spot (solvent 2) respectively. Mean recovery values of 103.5 % (solvent 1) and 102.3 % (solvent 2), and RSD values of 4.42 % (solvent 1) and 2.53 % (solvent 2) were obtained. The proposed method was applied for saccharin determination in two pharmaceutical preparations, effervescent tablets and a carbomer- based gel.
AB  - Predložena je jednostavna i selektivna metoda za određivanje saharina u farmaceutskim preparatima primenom visoko efikasne tankoslojne hromatografije. Određivanja su vršena na silika-gel pločama 60F254 koristeći kao mobilnu fazu smešu etilacetata, ugljentetrahlorida i sirćetne kiseline (3 + 4 + 0,5, v/v/v). Pripremljene su dve serije standardnih rastvora natrijumove soli saharina: u metanolu (rastvarač 1) i smeši etilacetat-sirćetna kiselina (9:1, v/v) (rastvarač 2). Kalibracione krive snimljene su na talasnoj dužini od 230 nm u opsegu nanetih količina natrijumove soli saharina (300-1200 ng), sa koeficijentima korelacije 0,998 (rastvarač 1) i 0,995 (rastvarač 2). U ispitivanom opsegu utvrđena je linearna zavisnost između površine pikova i količine natrijumove soli saharina. Limit detekcije i limit kvantifikacije saharina iznosili su redom 35 ng i 110 ng (rastvarač 1) i 45 ng i 150 ng (rastvarač 2). Dobijene su sledeće vrednosti za "recovery" i relativnu standardnu devijaciju: 103,5 % i 4,42 % (rastvarač 1) i 102,3 % i 2,53 % (rastvarač 2). Predložena metoda je primenjena za određivanje saharina u šumećim tabletama Kalcijum® i Daktanol® gelu.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Determination of saccharin in pharmaceuticals by high performance thin layer chromatography
T1  - Određivanje saharina u farmaceutskim preparatima primenom visoko efikasne tankoslojne hromatografije
VL  - 71
IS  - 6
SP  - 669
EP  - 676
DO  - 10.2298/JSC0606669C
ER  - 

@article{
author = "Čakar, Mira and Popović, Gordana",
year = "2006",
abstract = "A simple, accurate and selective high performance thin layer chromatographic method for the determination of saccharin in pharmaceuticals has been developed. The chromatography was performed on silica-gel 60F254 plates with ethyl acetate-carbon tetrachloride-acetic acid (3 + 4 + 0.5 v/v/v) as the mobile phase. The chromatographic zones corresponding to the saccharin spots were scanned in the reflectance/absorbance mode at λ=230 mm. For the standard curves, two series of saccharin sodium salt solutions were prepared: in methanol (solvent 1) and in ethyl acetate-acetic acid (9:1, v/v) mixture (solvent 2). A linear calibration relationship was observed within the concentration range from 300-1200 ng saccharin sodium salt per spot correlation coefficients being 0.998 (solvent 1) and 0.995 (solvent 2). The relationship between the peak area and the amount of saccharin sodium salt was evaluated by linear regression analysis. The limits of detection and quantification of saccharin sodium salt were 35 ng and 110 ng per spot (solvent 1), respectively, and 45 ng and 150 ng per spot (solvent 2) respectively. Mean recovery values of 103.5 % (solvent 1) and 102.3 % (solvent 2), and RSD values of 4.42 % (solvent 1) and 2.53 % (solvent 2) were obtained. The proposed method was applied for saccharin determination in two pharmaceutical preparations, effervescent tablets and a carbomer- based gel., Predložena je jednostavna i selektivna metoda za određivanje saharina u farmaceutskim preparatima primenom visoko efikasne tankoslojne hromatografije. Određivanja su vršena na silika-gel pločama 60F254 koristeći kao mobilnu fazu smešu etilacetata, ugljentetrahlorida i sirćetne kiseline (3 + 4 + 0,5, v/v/v). Pripremljene su dve serije standardnih rastvora natrijumove soli saharina: u metanolu (rastvarač 1) i smeši etilacetat-sirćetna kiselina (9:1, v/v) (rastvarač 2). Kalibracione krive snimljene su na talasnoj dužini od 230 nm u opsegu nanetih količina natrijumove soli saharina (300-1200 ng), sa koeficijentima korelacije 0,998 (rastvarač 1) i 0,995 (rastvarač 2). U ispitivanom opsegu utvrđena je linearna zavisnost između površine pikova i količine natrijumove soli saharina. Limit detekcije i limit kvantifikacije saharina iznosili su redom 35 ng i 110 ng (rastvarač 1) i 45 ng i 150 ng (rastvarač 2). Dobijene su sledeće vrednosti za "recovery" i relativnu standardnu devijaciju: 103,5 % i 4,42 % (rastvarač 1) i 102,3 % i 2,53 % (rastvarač 2). Predložena metoda je primenjena za određivanje saharina u šumećim tabletama Kalcijum® i Daktanol® gelu.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Determination of saccharin in pharmaceuticals by high performance thin layer chromatography, Određivanje saharina u farmaceutskim preparatima primenom visoko efikasne tankoslojne hromatografije",
volume = "71",
number = "6",
pages = "669-676",
doi = "10.2298/JSC0606669C"
}

Čakar, M.,& Popović, G.. (2006). Determination of saccharin in pharmaceuticals by high performance thin layer chromatography. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 71(6), 669-676.
https://doi.org/10.2298/JSC0606669C

Čakar M, Popović G. Determination of saccharin in pharmaceuticals by high performance thin layer chromatography. in Journal of the Serbian Chemical Society. 2006;71(6):669-676.
doi:10.2298/JSC0606669C .

Čakar, Mira, Popović, Gordana, "Determination of saccharin in pharmaceuticals by high performance thin layer chromatography" in Journal of the Serbian Chemical Society, 71, no. 6 (2006):669-676,
https://doi.org/10.2298/JSC0606669C . .

TY  - JOUR
AU  - Čakar, Mira
AU  - Popović, Gordana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/873
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Erratum: Determination of saccharin in pharmaceutical by high performance thin layer chromatography (Journal of the Serbian Chemical Society (2006) 71, 6, (667-674))
VL  - 71
IS  - 7
SP  - 849
UR  - https://hdl.handle.net/21.15107/rcub_farfar_873
ER  - 

@article{
author = "Čakar, Mira and Popović, Gordana",
year = "2006",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Erratum: Determination of saccharin in pharmaceutical by high performance thin layer chromatography (Journal of the Serbian Chemical Society (2006) 71, 6, (667-674))",
volume = "71",
number = "7",
pages = "849",
url = "https://hdl.handle.net/21.15107/rcub_farfar_873"
}

Čakar, M.,& Popović, G.. (2006). Erratum: Determination of saccharin in pharmaceutical by high performance thin layer chromatography (Journal of the Serbian Chemical Society (2006) 71, 6, (667-674)). in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 71(7), 849.
https://hdl.handle.net/21.15107/rcub_farfar_873

Čakar M, Popović G. Erratum: Determination of saccharin in pharmaceutical by high performance thin layer chromatography (Journal of the Serbian Chemical Society (2006) 71, 6, (667-674)). in Journal of the Serbian Chemical Society. 2006;71(7):849.
https://hdl.handle.net/21.15107/rcub_farfar_873 .

Čakar, Mira, Popović, Gordana, "Erratum: Determination of saccharin in pharmaceutical by high performance thin layer chromatography (Journal of the Serbian Chemical Society (2006) 71, 6, (667-674))" in Journal of the Serbian Chemical Society, 71, no. 7 (2006):849,
https://hdl.handle.net/21.15107/rcub_farfar_873 .

TY  - JOUR
AU  - Čakar, Mira
AU  - Popović, Gordana
AU  - Agbaba, Danica
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/612
AB  - Simple and reliable thin-layer chromatography-densitometry methods for determination of antimycotics (bifonazole, clotrimazole, and miconazole) and preservatives (benzyl alcohol and benzoic acid) were developed. The pairs bifonazole/benzyl alcohol, clotrimazole/benzyl alcohol, and miconazole/benzoic acid were determined simultaneously. The following mobile phases were used: ethyl acetate-n-heptane-methanol-diethylamine (3 + 4.5 + 1 + 0.2, v/v/v/v) for bifonazole and benzyl alcohol; n-butyl acetate-n-heptane-methanol-dietylamine (3 + 4.5 + 1 + 0.2, v/v/v/v) for clotrimazole and benzyl alcohol; and n-butyl acetate-carbon tetrachloride-methanol-diethylamine (3 + 6 + 2.5 + 0.5, v/v/v/v) for miconazole and benzoic acid. The chromatographic zones on silica gel plates were scanned in the reflectance/absorbance mode at 230 nm (bifonazole, benzyl alcohol, miconazole, and benzoic acid) and 210 nm (clotrimazole and benzyl alcohol). The recovery for all substances ranged from 98.7 to 100.7%. The limits of detection and quantitation were 0.03 to 0.2 mu g and 0.1 to 0.5 mu g/spot, respectively. The proposed methods were applied for determination of antimycotics and preservatives in commercially available pharmaceuticals.
PB  - AOAC Int, Gaithersburg
T2  - Journal of AOAC International
T1  - High-performance thin-layer chromatography determination of some antimycotic imidazole derivatives and preservatives in medicinal creams and a gel
VL  - 88
IS  - 5
SP  - 1544
EP  - 1548
DO  - 10.1093/jaoac/88.5.1544
ER  - 

@article{
author = "Čakar, Mira and Popović, Gordana and Agbaba, Danica",
year = "2005",
abstract = "Simple and reliable thin-layer chromatography-densitometry methods for determination of antimycotics (bifonazole, clotrimazole, and miconazole) and preservatives (benzyl alcohol and benzoic acid) were developed. The pairs bifonazole/benzyl alcohol, clotrimazole/benzyl alcohol, and miconazole/benzoic acid were determined simultaneously. The following mobile phases were used: ethyl acetate-n-heptane-methanol-diethylamine (3 + 4.5 + 1 + 0.2, v/v/v/v) for bifonazole and benzyl alcohol; n-butyl acetate-n-heptane-methanol-dietylamine (3 + 4.5 + 1 + 0.2, v/v/v/v) for clotrimazole and benzyl alcohol; and n-butyl acetate-carbon tetrachloride-methanol-diethylamine (3 + 6 + 2.5 + 0.5, v/v/v/v) for miconazole and benzoic acid. The chromatographic zones on silica gel plates were scanned in the reflectance/absorbance mode at 230 nm (bifonazole, benzyl alcohol, miconazole, and benzoic acid) and 210 nm (clotrimazole and benzyl alcohol). The recovery for all substances ranged from 98.7 to 100.7%. The limits of detection and quantitation were 0.03 to 0.2 mu g and 0.1 to 0.5 mu g/spot, respectively. The proposed methods were applied for determination of antimycotics and preservatives in commercially available pharmaceuticals.",
publisher = "AOAC Int, Gaithersburg",
journal = "Journal of AOAC International",
title = "High-performance thin-layer chromatography determination of some antimycotic imidazole derivatives and preservatives in medicinal creams and a gel",
volume = "88",
number = "5",
pages = "1544-1548",
doi = "10.1093/jaoac/88.5.1544"
}

Čakar, M., Popović, G.,& Agbaba, D.. (2005). High-performance thin-layer chromatography determination of some antimycotic imidazole derivatives and preservatives in medicinal creams and a gel. in Journal of AOAC International
AOAC Int, Gaithersburg., 88(5), 1544-1548.
https://doi.org/10.1093/jaoac/88.5.1544

Čakar M, Popović G, Agbaba D. High-performance thin-layer chromatography determination of some antimycotic imidazole derivatives and preservatives in medicinal creams and a gel. in Journal of AOAC International. 2005;88(5):1544-1548.
doi:10.1093/jaoac/88.5.1544 .

Čakar, Mira, Popović, Gordana, Agbaba, Danica, "High-performance thin-layer chromatography determination of some antimycotic imidazole derivatives and preservatives in medicinal creams and a gel" in Journal of AOAC International, 88, no. 5 (2005):1544-1548,
https://doi.org/10.1093/jaoac/88.5.1544 . .

TY  - JOUR
AU  - Vasić, Vesna
AU  - Živanović, MA
AU  - Čakar, Mira
AU  - Savić, Jasmina Z.
AU  - Nedeljković, Jovan M.
AU  - Bugarčić, Živadin
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/591
AB  - The reaction mechanism and thermodynamic parameters of the complex formation between [PdCl(dien)](+) and sulfur-containing ligands L-cysteine and glutathione (GSH) were investigated in the presence of sodium dodecyl sulfate micelles in the pH range 0.5-3.5. The reaction rates were determined under pseudo-first-order conditions (ligand in excess) in the temperature range 276-299 K by using the stopped-flow technique. A reaction mechanism was proposed that consisted of at least two parallel paths involving protonated and zwitterionic forms of thiols. The pH effects on reaction rate were interpreted in terms of the electrostatic interactions between the negatively charged micelle surface and different ionic forms of the ligand species. The calculation of pH-dependent activation parameters (Delta H-not equal and Delta S-not equal) revealed the considerable catalytic effects on the rate of complexation. The entropy of activation is strongly negative in the presence and absence of micelles, which is compatible with an associative reaction mechanism. Copyright
PB  - John Wiley & Sons Ltd, Chichester
T2  - Journal of Physical Organic Chemistry
T1  - Influence of acidity on the reaction between [PdCl(dien)](+) and L-cysteine or glutathione in the presence of sodium dodecyl sulfate micelles
VL  - 18
IS  - 5
SP  - 441
EP  - 447
DO  - 10.1002/poc.880
ER  - 

@article{
author = "Vasić, Vesna and Živanović, MA and Čakar, Mira and Savić, Jasmina Z. and Nedeljković, Jovan M. and Bugarčić, Živadin",
year = "2005",
abstract = "The reaction mechanism and thermodynamic parameters of the complex formation between [PdCl(dien)](+) and sulfur-containing ligands L-cysteine and glutathione (GSH) were investigated in the presence of sodium dodecyl sulfate micelles in the pH range 0.5-3.5. The reaction rates were determined under pseudo-first-order conditions (ligand in excess) in the temperature range 276-299 K by using the stopped-flow technique. A reaction mechanism was proposed that consisted of at least two parallel paths involving protonated and zwitterionic forms of thiols. The pH effects on reaction rate were interpreted in terms of the electrostatic interactions between the negatively charged micelle surface and different ionic forms of the ligand species. The calculation of pH-dependent activation parameters (Delta H-not equal and Delta S-not equal) revealed the considerable catalytic effects on the rate of complexation. The entropy of activation is strongly negative in the presence and absence of micelles, which is compatible with an associative reaction mechanism. Copyright",
publisher = "John Wiley & Sons Ltd, Chichester",
journal = "Journal of Physical Organic Chemistry",
title = "Influence of acidity on the reaction between [PdCl(dien)](+) and L-cysteine or glutathione in the presence of sodium dodecyl sulfate micelles",
volume = "18",
number = "5",
pages = "441-447",
doi = "10.1002/poc.880"
}

Vasić, V., Živanović, M., Čakar, M., Savić, J. Z., Nedeljković, J. M.,& Bugarčić, Ž.. (2005). Influence of acidity on the reaction between [PdCl(dien)](+) and L-cysteine or glutathione in the presence of sodium dodecyl sulfate micelles. in Journal of Physical Organic Chemistry
John Wiley & Sons Ltd, Chichester., 18(5), 441-447.
https://doi.org/10.1002/poc.880

Vasić V, Živanović M, Čakar M, Savić JZ, Nedeljković JM, Bugarčić Ž. Influence of acidity on the reaction between [PdCl(dien)](+) and L-cysteine or glutathione in the presence of sodium dodecyl sulfate micelles. in Journal of Physical Organic Chemistry. 2005;18(5):441-447.
doi:10.1002/poc.880 .

Vasić, Vesna, Živanović, MA, Čakar, Mira, Savić, Jasmina Z., Nedeljković, Jovan M., Bugarčić, Živadin, "Influence of acidity on the reaction between [PdCl(dien)](+) and L-cysteine or glutathione in the presence of sodium dodecyl sulfate micelles" in Journal of Physical Organic Chemistry, 18, no. 5 (2005):441-447,
https://doi.org/10.1002/poc.880 . .

TY  - JOUR
AU  - Čakar, Mira
AU  - Popović, Gordana
AU  - Vladimirov, Sote
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/524
AB  - A simple and reliable HPTLC method has been developed for simultaneous determination of antimycotics (bifonazole and econazole nitrate) and preservatives (methyl- and propylparaben) in medicinal creams. Chromatography was performed on silica gel plates with ethyl acetate-n-hexane-methanol-ammonia-diethylamine, 0.5 + 4 + 0.8 + 0.4 + 2 (v/v) as mobile phase. Chromatographic zones corresponding to spots of econazole nitrate, bifonazole, and parabens were scanned in reflectance/absorbance mode at lambda = 230, 250, and 300 nm, respectively. The method was successfully applied to simultaneous determination of the compounds in commercially available pharmaceuticals.
PB  - Springer Nature
T2  - Journal of Planar Chromatography - Modern TLC
T1  - Simultaneous HPTLC determination of imidazole antimycotics and parabens in creams
VL  - 17
IS  - 3
SP  - 177
EP  - 180
DO  - 10.1556/JPC.17.2004.3.4
ER  - 

@article{
author = "Čakar, Mira and Popović, Gordana and Vladimirov, Sote",
year = "2004",
abstract = "A simple and reliable HPTLC method has been developed for simultaneous determination of antimycotics (bifonazole and econazole nitrate) and preservatives (methyl- and propylparaben) in medicinal creams. Chromatography was performed on silica gel plates with ethyl acetate-n-hexane-methanol-ammonia-diethylamine, 0.5 + 4 + 0.8 + 0.4 + 2 (v/v) as mobile phase. Chromatographic zones corresponding to spots of econazole nitrate, bifonazole, and parabens were scanned in reflectance/absorbance mode at lambda = 230, 250, and 300 nm, respectively. The method was successfully applied to simultaneous determination of the compounds in commercially available pharmaceuticals.",
publisher = "Springer Nature",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "Simultaneous HPTLC determination of imidazole antimycotics and parabens in creams",
volume = "17",
number = "3",
pages = "177-180",
doi = "10.1556/JPC.17.2004.3.4"
}

Čakar, M., Popović, G.,& Vladimirov, S.. (2004). Simultaneous HPTLC determination of imidazole antimycotics and parabens in creams. in Journal of Planar Chromatography - Modern TLC
Springer Nature., 17(3), 177-180.
https://doi.org/10.1556/JPC.17.2004.3.4

Čakar M, Popović G, Vladimirov S. Simultaneous HPTLC determination of imidazole antimycotics and parabens in creams. in Journal of Planar Chromatography - Modern TLC. 2004;17(3):177-180.
doi:10.1556/JPC.17.2004.3.4 .

Čakar, Mira, Popović, Gordana, Vladimirov, Sote, "Simultaneous HPTLC determination of imidazole antimycotics and parabens in creams" in Journal of Planar Chromatography - Modern TLC, 17, no. 3 (2004):177-180,
https://doi.org/10.1556/JPC.17.2004.3.4 . .

TY  - JOUR
AU  - Popović, Gordana
AU  - Čakar, Mira
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/550
AB  - The equlibria of bifonazole in saturated water solution within the pH range 4 to 10 [I = 0.1 mol/dm3 (NaCl); 25 ºC] were studied spectrophotometrically. Based on the equlibrium constants determined in a heterogeneous system, the acidity constant (pKa = 5.72) and solubility in water (S=10-5.79+10-(pH + 0.07))were calculated. The influence of β-cyclodextrin on bifonazole solubility was examined in the presence of 10-3 and 10-4 mol/dm3 β-cyclodextrin. At pH values over 8, bifonazole solubility was two- and 13-fold increased in the presence of 10-4 and 10-3 mol/dm3 β-cyclodextrin respectively, compared to its solubility in water. The ratio of bifonazole solubility in the presence of β-cyclodextrin and that in water decreased in parallel to the increase of acidity.
AB  - Spektrofotometrijski su proučavane ravnoteže u zasićenom vodenom rastvoru bifonazola u pH intervalu 4–10. Na osnovu ravnotežnih konstanti određenih u heterogenom sistemu izračunata je kiselinska konstanta (pKa = 5,72) i rastvorljivost bifonazola u funkciji kiselosti rastvora (S=10-5.79+10-(pH + 0.07)) Uticaj β-ciklodekstrina (β-CD) na rastvorljivost ispitivan je u prisustvu 10-3 i 10-4 mol/dm3 β-CD. Utvrđeno je da pri pH vrednostima većim od 8 dolazi do povećanja rastvorljivosti 2 puta (u prisustvu 10-4 mol/dm3 β-CD) i 13 puta (u prisustvu 10-3 mol/dm3 β-CD) u odnosu na rastvorljivost bifonazola u vodi (u odsustvu β-CD). Odnos rastvorljivosti bifonazola u prisustvu β-CD i rastvorljivosti u vodi smanjuje se sa povećanjem kiselosti rastvora.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - The effect of β-cyclodextrin and pH on bifonazole hydrosolubility
T1  - Uticaj β-ciklodekstrina i PH na rastvorljivost bifonazola u vodi
VL  - 69
IS  - 3
SP  - 225
EP  - 231
DO  - 10.2298/JSC0403225P
ER  - 

@article{
author = "Popović, Gordana and Čakar, Mira",
year = "2004",
abstract = "The equlibria of bifonazole in saturated water solution within the pH range 4 to 10 [I = 0.1 mol/dm3 (NaCl); 25 ºC] were studied spectrophotometrically. Based on the equlibrium constants determined in a heterogeneous system, the acidity constant (pKa = 5.72) and solubility in water (S=10-5.79+10-(pH + 0.07))were calculated. The influence of β-cyclodextrin on bifonazole solubility was examined in the presence of 10-3 and 10-4 mol/dm3 β-cyclodextrin. At pH values over 8, bifonazole solubility was two- and 13-fold increased in the presence of 10-4 and 10-3 mol/dm3 β-cyclodextrin respectively, compared to its solubility in water. The ratio of bifonazole solubility in the presence of β-cyclodextrin and that in water decreased in parallel to the increase of acidity., Spektrofotometrijski su proučavane ravnoteže u zasićenom vodenom rastvoru bifonazola u pH intervalu 4–10. Na osnovu ravnotežnih konstanti određenih u heterogenom sistemu izračunata je kiselinska konstanta (pKa = 5,72) i rastvorljivost bifonazola u funkciji kiselosti rastvora (S=10-5.79+10-(pH + 0.07)) Uticaj β-ciklodekstrina (β-CD) na rastvorljivost ispitivan je u prisustvu 10-3 i 10-4 mol/dm3 β-CD. Utvrđeno je da pri pH vrednostima većim od 8 dolazi do povećanja rastvorljivosti 2 puta (u prisustvu 10-4 mol/dm3 β-CD) i 13 puta (u prisustvu 10-3 mol/dm3 β-CD) u odnosu na rastvorljivost bifonazola u vodi (u odsustvu β-CD). Odnos rastvorljivosti bifonazola u prisustvu β-CD i rastvorljivosti u vodi smanjuje se sa povećanjem kiselosti rastvora.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "The effect of β-cyclodextrin and pH on bifonazole hydrosolubility, Uticaj β-ciklodekstrina i PH na rastvorljivost bifonazola u vodi",
volume = "69",
number = "3",
pages = "225-231",
doi = "10.2298/JSC0403225P"
}

Popović, G.,& Čakar, M.. (2004). The effect of β-cyclodextrin and pH on bifonazole hydrosolubility. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 69(3), 225-231.
https://doi.org/10.2298/JSC0403225P

Popović G, Čakar M. The effect of β-cyclodextrin and pH on bifonazole hydrosolubility. in Journal of the Serbian Chemical Society. 2004;69(3):225-231.
doi:10.2298/JSC0403225P .

Popović, Gordana, Čakar, Mira, "The effect of β-cyclodextrin and pH on bifonazole hydrosolubility" in Journal of the Serbian Chemical Society, 69, no. 3 (2004):225-231,
https://doi.org/10.2298/JSC0403225P . .

TY  - JOUR
AU  - Popović, Gordana
AU  - Čakar, Mira
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/512
AB  - Acidity constants (Ka) and intrinsic hydrosolubility (Ks0) of two parabens, methylparaben and propylparaben, were spectrophotometrically determined at 25oC and a constant ionic strength of I=0.1 M (NaCl). Based on the determined equilibrium constants Ks0 and Ka, equilibrium constant Ks1 in heterogeneous system of methyl-and propylparaben was calculated. Solubility of the two parabens as a function of solution acidity was calculated applying the equation: s1 s0 3 [ ] S [H O ] K K + = + In addition, the effects of varying β-cyclodextrin concentrations on pKa values of the two parabens were examined. The results showed that β-CD influenced absorption spectra of the parabens (a decreased absorptivity and a bathochromic shift of the absorption maxima), but their pKa values remained almost unchanged.
AB  - Spektrofotometrijski su određene kiselinske konstante (Ka) i osnovna rastvorljivost (Ks0) u vodi metilparabena i propilparabena. Određivanja su vršena na temperaturi od 25 oC i pri konstantnoj jonskoj sili I=0.1 M (NaCl). Na osnovu određenih ravnotežnih konstanti Ks0 i Ka izračunata je ravnotežna konstanta Ks1 u heterogenom sistemu parabena. Rastvorljivost parabena u funkciji kiselosti rastvora izračunata je primenom jednačine 1 0 3 [ ] [ ] s s K S K H O+ = + Pored toga, ispitan je uticaj različitih koncentracija β-ciklodekstrina na pKa vrednosti datih parabena.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Protolytic equilibria in homogeneous and heterogeneous aqueous systems of methyl- and propylparaben and influence of β-cyclodextrin on pKa values
T1  - Protolitičke ravnoteže u homogenim i heterogenim vodenim sistemima metil- i propilparabena i uticaj β -ciklodekstrina na pKa vrednosti
VL  - 54
IS  - 5
SP  - 601
EP  - 611
UR  - https://hdl.handle.net/21.15107/rcub_farfar_512
ER  - 

@article{
author = "Popović, Gordana and Čakar, Mira",
year = "2004",
abstract = "Acidity constants (Ka) and intrinsic hydrosolubility (Ks0) of two parabens, methylparaben and propylparaben, were spectrophotometrically determined at 25oC and a constant ionic strength of I=0.1 M (NaCl). Based on the determined equilibrium constants Ks0 and Ka, equilibrium constant Ks1 in heterogeneous system of methyl-and propylparaben was calculated. Solubility of the two parabens as a function of solution acidity was calculated applying the equation: s1 s0 3 [ ] S [H O ] K K + = + In addition, the effects of varying β-cyclodextrin concentrations on pKa values of the two parabens were examined. The results showed that β-CD influenced absorption spectra of the parabens (a decreased absorptivity and a bathochromic shift of the absorption maxima), but their pKa values remained almost unchanged., Spektrofotometrijski su određene kiselinske konstante (Ka) i osnovna rastvorljivost (Ks0) u vodi metilparabena i propilparabena. Određivanja su vršena na temperaturi od 25 oC i pri konstantnoj jonskoj sili I=0.1 M (NaCl). Na osnovu određenih ravnotežnih konstanti Ks0 i Ka izračunata je ravnotežna konstanta Ks1 u heterogenom sistemu parabena. Rastvorljivost parabena u funkciji kiselosti rastvora izračunata je primenom jednačine 1 0 3 [ ] [ ] s s K S K H O+ = + Pored toga, ispitan je uticaj različitih koncentracija β-ciklodekstrina na pKa vrednosti datih parabena.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Protolytic equilibria in homogeneous and heterogeneous aqueous systems of methyl- and propylparaben and influence of β-cyclodextrin on pKa values, Protolitičke ravnoteže u homogenim i heterogenim vodenim sistemima metil- i propilparabena i uticaj β -ciklodekstrina na pKa vrednosti",
volume = "54",
number = "5",
pages = "601-611",
url = "https://hdl.handle.net/21.15107/rcub_farfar_512"
}

Popović, G.,& Čakar, M.. (2004). Protolytic equilibria in homogeneous and heterogeneous aqueous systems of methyl- and propylparaben and influence of β-cyclodextrin on pKa values. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 54(5), 601-611.
https://hdl.handle.net/21.15107/rcub_farfar_512

Popović G, Čakar M. Protolytic equilibria in homogeneous and heterogeneous aqueous systems of methyl- and propylparaben and influence of β-cyclodextrin on pKa values. in Arhiv za farmaciju. 2004;54(5):601-611.
https://hdl.handle.net/21.15107/rcub_farfar_512 .

Popović, Gordana, Čakar, Mira, "Protolytic equilibria in homogeneous and heterogeneous aqueous systems of methyl- and propylparaben and influence of β-cyclodextrin on pKa values" in Arhiv za farmaciju, 54, no. 5 (2004):601-611,
https://hdl.handle.net/21.15107/rcub_farfar_512 .

TY  - JOUR
AU  - Čakar, Mira
AU  - Popović, Gordana
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/543
AB  - A direct spectrophotometric method for the determination of bifonazole and clotrimazole in commercial lotions Bicutrin® and Canesten®, respectively, has been developed. The determinations were performed in a 0.1 M HCl solution at 257 nm (bifonazole) and 225 nm (clotrimazole). A calibration curves were obtained in the concentration range 1.5 -15.0 µg/ml and 2.5 - 25.0 µg/ml for bifonazole and clotrimazole, respectively, with correlation coefficient is 0.9999 for both curve. The accuracy and reproducibility of the method was checked by analyzing solutions of three different concentrations of bifonazole (recovery 98.7 - 99.7 % ; RSD 0.60-1.55 % ) and clotrimazole (recovery 98.3 - 99.1 % ; RSD 0.96 - 1.67 % ). The method proposed in this study is fast, accurate and reproductive. It enables the direct spectrophotometric determination of bifonazole and clotrimazole in lotions without previous isolation. The simplicity and low cost can be advantage of this method.
AB  - U radu je predložena direktna spektrofotometrijska metoda za određivanje antimikotika bifonazola i klotrimazola u losionima Bicutrin®, odnosno Canesten®. Određivanja su vršena u 0,1 M HCl na talasnoj dužini 257 nm (bifonazol), odnosno 225 nm (klotrimazol). Kalibraciona kriva dobijena je u opsegu koncentracija bifonazola 1,5-15 µg/ml, i klotrimazola 2,5-25 µg/ml, sa koeficientom korelacije 0,9999 za obe krive. Tačnost i reproduktivnost metode proverena je analizom rastvora tri različite koncentracije bifonazola („recovery” 98,7-99,7 % ; RSD 0,60-1,55 % ) i klotrimazola („recovery” 98,3-99,1 % ; RSD 0,96-1,67 % ). Dobijeni rezultati ukazuju na tačnost i reproduktivnost predložene spektrofotometrijske metode, kao i na mogućnost direknog spektrofotometrijskog određivanja bifonazola i klotrimazola u odgovarajućim losionima bez prethodnog izolovanja.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Spectrophotometric determination of Bifonazole and Clotrimazole in lotions Bicutrin® and Canesten®
T1  - Spektrofotometrijsko određivanje Bifonazola i Klotrimazola u losionima Bicutrin® i Canesten®
VL  - 54
IS  - 1-2
SP  - 1
EP  - 13
UR  - https://hdl.handle.net/21.15107/rcub_farfar_543
ER  - 

@article{
author = "Čakar, Mira and Popović, Gordana",
year = "2004",
abstract = "A direct spectrophotometric method for the determination of bifonazole and clotrimazole in commercial lotions Bicutrin® and Canesten®, respectively, has been developed. The determinations were performed in a 0.1 M HCl solution at 257 nm (bifonazole) and 225 nm (clotrimazole). A calibration curves were obtained in the concentration range 1.5 -15.0 µg/ml and 2.5 - 25.0 µg/ml for bifonazole and clotrimazole, respectively, with correlation coefficient is 0.9999 for both curve. The accuracy and reproducibility of the method was checked by analyzing solutions of three different concentrations of bifonazole (recovery 98.7 - 99.7 % ; RSD 0.60-1.55 % ) and clotrimazole (recovery 98.3 - 99.1 % ; RSD 0.96 - 1.67 % ). The method proposed in this study is fast, accurate and reproductive. It enables the direct spectrophotometric determination of bifonazole and clotrimazole in lotions without previous isolation. The simplicity and low cost can be advantage of this method., U radu je predložena direktna spektrofotometrijska metoda za određivanje antimikotika bifonazola i klotrimazola u losionima Bicutrin®, odnosno Canesten®. Određivanja su vršena u 0,1 M HCl na talasnoj dužini 257 nm (bifonazol), odnosno 225 nm (klotrimazol). Kalibraciona kriva dobijena je u opsegu koncentracija bifonazola 1,5-15 µg/ml, i klotrimazola 2,5-25 µg/ml, sa koeficientom korelacije 0,9999 za obe krive. Tačnost i reproduktivnost metode proverena je analizom rastvora tri različite koncentracije bifonazola („recovery” 98,7-99,7 % ; RSD 0,60-1,55 % ) i klotrimazola („recovery” 98,3-99,1 % ; RSD 0,96-1,67 % ). Dobijeni rezultati ukazuju na tačnost i reproduktivnost predložene spektrofotometrijske metode, kao i na mogućnost direknog spektrofotometrijskog određivanja bifonazola i klotrimazola u odgovarajućim losionima bez prethodnog izolovanja.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Spectrophotometric determination of Bifonazole and Clotrimazole in lotions Bicutrin® and Canesten®, Spektrofotometrijsko određivanje Bifonazola i Klotrimazola u losionima Bicutrin® i Canesten®",
volume = "54",
number = "1-2",
pages = "1-13",
url = "https://hdl.handle.net/21.15107/rcub_farfar_543"
}

Čakar, M.,& Popović, G.. (2004). Spectrophotometric determination of Bifonazole and Clotrimazole in lotions Bicutrin® and Canesten®. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 54(1-2), 1-13.
https://hdl.handle.net/21.15107/rcub_farfar_543

Čakar M, Popović G. Spectrophotometric determination of Bifonazole and Clotrimazole in lotions Bicutrin® and Canesten®. in Arhiv za farmaciju. 2004;54(1-2):1-13.
https://hdl.handle.net/21.15107/rcub_farfar_543 .

Čakar, Mira, Popović, Gordana, "Spectrophotometric determination of Bifonazole and Clotrimazole in lotions Bicutrin® and Canesten®" in Arhiv za farmaciju, 54, no. 1-2 (2004):1-13,
https://hdl.handle.net/21.15107/rcub_farfar_543 .

TY  - JOUR
AU  - Popović, Gordana
AU  - Čakar, Mira
AU  - Vučićević, Katarina
AU  - Vladimirov, S
AU  - Agbaba, Danica
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/479
AB  - HPTLC and HPLC methods have been established for separation and quantitative determination of econazole nitrate. HPTLC was performed on silica gel plates with n-butyl acetate-carbon tetrachloride-methanol-diethylamine, 3 + 6 + 2.5 + 0.5 (v/v), as mobile phase. Chromatographic zones, or spots, of econazole base and nitrate were used to quantify econazole nitrate. HPLC was performed on amino and C-8 columns with acetonitrile-water, 30 + 70 (v/v), pH 2.5 (adjusted with phosphoric acid), as a mobile phase. The chromatograms were characterized by single peaks of econazole (amino column) or nitrate (C-8 column). The methods were successfully used for determination of econazole nitrate in spray solution and vaginal pessaries.
PB  - Research Inst Medicinal Plants, Budakalasz
T2  - Journal of Planar Chromatography - Modern TLC
T1  - Comparison of HPTLC and HPLC for determination of econazole nitrate in topical dosage forms
VL  - 17
IS  - 2
SP  - 109
EP  - 112
DO  - 10.1556/JPC.17.2004.2.5
ER  - 

@article{
author = "Popović, Gordana and Čakar, Mira and Vučićević, Katarina and Vladimirov, S and Agbaba, Danica",
year = "2004",
abstract = "HPTLC and HPLC methods have been established for separation and quantitative determination of econazole nitrate. HPTLC was performed on silica gel plates with n-butyl acetate-carbon tetrachloride-methanol-diethylamine, 3 + 6 + 2.5 + 0.5 (v/v), as mobile phase. Chromatographic zones, or spots, of econazole base and nitrate were used to quantify econazole nitrate. HPLC was performed on amino and C-8 columns with acetonitrile-water, 30 + 70 (v/v), pH 2.5 (adjusted with phosphoric acid), as a mobile phase. The chromatograms were characterized by single peaks of econazole (amino column) or nitrate (C-8 column). The methods were successfully used for determination of econazole nitrate in spray solution and vaginal pessaries.",
publisher = "Research Inst Medicinal Plants, Budakalasz",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "Comparison of HPTLC and HPLC for determination of econazole nitrate in topical dosage forms",
volume = "17",
number = "2",
pages = "109-112",
doi = "10.1556/JPC.17.2004.2.5"
}

Popović, G., Čakar, M., Vučićević, K., Vladimirov, S.,& Agbaba, D.. (2004). Comparison of HPTLC and HPLC for determination of econazole nitrate in topical dosage forms. in Journal of Planar Chromatography - Modern TLC
Research Inst Medicinal Plants, Budakalasz., 17(2), 109-112.
https://doi.org/10.1556/JPC.17.2004.2.5

Popović G, Čakar M, Vučićević K, Vladimirov S, Agbaba D. Comparison of HPTLC and HPLC for determination of econazole nitrate in topical dosage forms. in Journal of Planar Chromatography - Modern TLC. 2004;17(2):109-112.
doi:10.1556/JPC.17.2004.2.5 .

Popović, Gordana, Čakar, Mira, Vučićević, Katarina, Vladimirov, S, Agbaba, Danica, "Comparison of HPTLC and HPLC for determination of econazole nitrate in topical dosage forms" in Journal of Planar Chromatography - Modern TLC, 17, no. 2 (2004):109-112,
https://doi.org/10.1556/JPC.17.2004.2.5 . .

TY  - JOUR
AU  - Vasić, Vesna
AU  - Čakar, Mira
AU  - Savić, J
AU  - Petrović, B
AU  - Nedeljković, J
AU  - Bugarcić, I
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/456
AB  - The effect of sodium dodecyl sulfate (SDS) micelles on the kinetics of the complex formation between [PdCl(dien)](+) and sulfur containing ligands L-cysteine and glutathione (GSH) was investigated by using the stopped-flow technique under pseudo-first order conditions (ligand in excess) in the acidity range from pH 1 to 6. The presence of anionic micelles induced the acceleration of the complex formation in the entire acidity range with the maxima corresponding to the first protolytic constant of the ligands. This effect was interpreted in terms of the attractive electrostatic interaction between reacting species and the micellar surface and their effective concentration in the vicinity of micelles. An increase of the ionic strength leads to a decrease of the rate of complex formation in the presence of anionic micelles due to competition of reactive species with cations originating from inert salt for the micellar surface. The calculation of activation parameters revealed that the entropy of activation is strongly negative in the presence and in the absence of micelles, which is compatible with an associative reaction mechanism.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Polyhedron
T1  - Influence of sodium dodecyl sulfate on the kinetics of complex formation between [PdCl(dien)](+) and sulfur containing ligands L-cysteine and glutathione
VL  - 22
IS  - 2
SP  - 279
EP  - 285
DO  - 10.1016/S0277-5387(02)01307-4
ER  - 

@article{
author = "Vasić, Vesna and Čakar, Mira and Savić, J and Petrović, B and Nedeljković, J and Bugarcić, I",
year = "2003",
abstract = "The effect of sodium dodecyl sulfate (SDS) micelles on the kinetics of the complex formation between [PdCl(dien)](+) and sulfur containing ligands L-cysteine and glutathione (GSH) was investigated by using the stopped-flow technique under pseudo-first order conditions (ligand in excess) in the acidity range from pH 1 to 6. The presence of anionic micelles induced the acceleration of the complex formation in the entire acidity range with the maxima corresponding to the first protolytic constant of the ligands. This effect was interpreted in terms of the attractive electrostatic interaction between reacting species and the micellar surface and their effective concentration in the vicinity of micelles. An increase of the ionic strength leads to a decrease of the rate of complex formation in the presence of anionic micelles due to competition of reactive species with cations originating from inert salt for the micellar surface. The calculation of activation parameters revealed that the entropy of activation is strongly negative in the presence and in the absence of micelles, which is compatible with an associative reaction mechanism.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Polyhedron",
title = "Influence of sodium dodecyl sulfate on the kinetics of complex formation between [PdCl(dien)](+) and sulfur containing ligands L-cysteine and glutathione",
volume = "22",
number = "2",
pages = "279-285",
doi = "10.1016/S0277-5387(02)01307-4"
}

Vasić, V., Čakar, M., Savić, J., Petrović, B., Nedeljković, J.,& Bugarcić, I.. (2003). Influence of sodium dodecyl sulfate on the kinetics of complex formation between [PdCl(dien)](+) and sulfur containing ligands L-cysteine and glutathione. in Polyhedron
Pergamon-Elsevier Science Ltd, Oxford., 22(2), 279-285.
https://doi.org/10.1016/S0277-5387(02)01307-4

Vasić V, Čakar M, Savić J, Petrović B, Nedeljković J, Bugarcić I. Influence of sodium dodecyl sulfate on the kinetics of complex formation between [PdCl(dien)](+) and sulfur containing ligands L-cysteine and glutathione. in Polyhedron. 2003;22(2):279-285.
doi:10.1016/S0277-5387(02)01307-4 .

Vasić, Vesna, Čakar, Mira, Savić, J, Petrović, B, Nedeljković, J, Bugarcić, I, "Influence of sodium dodecyl sulfate on the kinetics of complex formation between [PdCl(dien)](+) and sulfur containing ligands L-cysteine and glutathione" in Polyhedron, 22, no. 2 (2003):279-285,
https://doi.org/10.1016/S0277-5387(02)01307-4 . .

TY  - JOUR
AU  - Popović, Gordana
AU  - Čakar, Mira
AU  - Agbaba, Danica
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/431
AB  - A second order derivative spectrophotometric method for the determination of bifonazole in the presence of methyland propyl p-hydroxybenzoate as preservatives has been developed. The determination was performed in a 0.1 M HCl solution at 241.5 nm, a wavelength corresponding to the intersection of the second order derivative spectra (D-2) of methyl- and propyl p-hydroxybenzoate with the axis (zero-crossing point). On the basis of the knowledge of acidity constants and solubility, as well as of the investigations of zero-order and D-2 spectra of bifonazole and preservatives, these conditions were chosen as optimal ones. A calibration curve constructed for bifonazole concentrations ranging from 1.5 to 15 mug/ml had a correlation coefficient of 0.9998. Reliability and reproducibility of the method was checked by analyzing laboratory mixtures of bifonazole and preservatives (recovery 99.97-102.7%; RDS 0.48-1.46%). The proposed method was applied for the determination of bifonazole in a commercial cream formulation. The mean value of bifonazole obtained per 100 g cream was 1.029 g (102.9% of the labeled claim) with a RSD of 0.60%.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Determination of bifonazole in creams containing methyl- and propyl p-hydroxybenzoate by derivative spectrophotometric method
VL  - 33
IS  - 1
SP  - 131
EP  - 136
DO  - 10.1016/S0731-7085(03)00228-0
ER  - 

@article{
author = "Popović, Gordana and Čakar, Mira and Agbaba, Danica",
year = "2003",
abstract = "A second order derivative spectrophotometric method for the determination of bifonazole in the presence of methyland propyl p-hydroxybenzoate as preservatives has been developed. The determination was performed in a 0.1 M HCl solution at 241.5 nm, a wavelength corresponding to the intersection of the second order derivative spectra (D-2) of methyl- and propyl p-hydroxybenzoate with the axis (zero-crossing point). On the basis of the knowledge of acidity constants and solubility, as well as of the investigations of zero-order and D-2 spectra of bifonazole and preservatives, these conditions were chosen as optimal ones. A calibration curve constructed for bifonazole concentrations ranging from 1.5 to 15 mug/ml had a correlation coefficient of 0.9998. Reliability and reproducibility of the method was checked by analyzing laboratory mixtures of bifonazole and preservatives (recovery 99.97-102.7%; RDS 0.48-1.46%). The proposed method was applied for the determination of bifonazole in a commercial cream formulation. The mean value of bifonazole obtained per 100 g cream was 1.029 g (102.9% of the labeled claim) with a RSD of 0.60%.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Determination of bifonazole in creams containing methyl- and propyl p-hydroxybenzoate by derivative spectrophotometric method",
volume = "33",
number = "1",
pages = "131-136",
doi = "10.1016/S0731-7085(03)00228-0"
}

Popović, G., Čakar, M.,& Agbaba, D.. (2003). Determination of bifonazole in creams containing methyl- and propyl p-hydroxybenzoate by derivative spectrophotometric method. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 33(1), 131-136.
https://doi.org/10.1016/S0731-7085(03)00228-0

Popović G, Čakar M, Agbaba D. Determination of bifonazole in creams containing methyl- and propyl p-hydroxybenzoate by derivative spectrophotometric method. in Journal of Pharmaceutical and Biomedical Analysis. 2003;33(1):131-136.
doi:10.1016/S0731-7085(03)00228-0 .

Popović, Gordana, Čakar, Mira, Agbaba, Danica, "Determination of bifonazole in creams containing methyl- and propyl p-hydroxybenzoate by derivative spectrophotometric method" in Journal of Pharmaceutical and Biomedical Analysis, 33, no. 1 (2003):131-136,
https://doi.org/10.1016/S0731-7085(03)00228-0 . .

TY  - CONF
AU  - Čakar, Mira
AU  - Popović, Gordana
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/383
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Spectrophotometric determination of bifonazole in lotion
T1  - Spektrofotometrijsko određivanje bifonazola u losionu
VL  - 52
IS  - 4
SP  - 504
EP  - 505
UR  - https://hdl.handle.net/21.15107/rcub_farfar_383
ER  - 

@conference{
author = "Čakar, Mira and Popović, Gordana",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Spectrophotometric determination of bifonazole in lotion, Spektrofotometrijsko određivanje bifonazola u losionu",
volume = "52",
number = "4",
pages = "504-505",
url = "https://hdl.handle.net/21.15107/rcub_farfar_383"
}

Čakar, M.,& Popović, G.. (2002). Spectrophotometric determination of bifonazole in lotion. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 504-505.
https://hdl.handle.net/21.15107/rcub_farfar_383

Čakar M, Popović G. Spectrophotometric determination of bifonazole in lotion. in Arhiv za farmaciju. 2002;52(4):504-505.
https://hdl.handle.net/21.15107/rcub_farfar_383 .

Čakar, Mira, Popović, Gordana, "Spectrophotometric determination of bifonazole in lotion" in Arhiv za farmaciju, 52, no. 4 (2002):504-505,
https://hdl.handle.net/21.15107/rcub_farfar_383 .

TY  - CONF
AU  - Čakar, Mira
AU  - Vasić, Vesna
AU  - Savić, Jasmina Z.
AU  - Bugarčić, Živadin
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/384
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - The spectrophotometric investigation of the reaction of [Pd(dien)Cl]+ with amino acids
T1  - Spektrofotometrijsko ispitivanje reakcije [Pd(dien)Cl]+ sa amino kiselinama
VL  - 52
IS  - 4
SP  - 506
EP  - 507
UR  - https://hdl.handle.net/21.15107/rcub_farfar_384
ER  - 

@conference{
author = "Čakar, Mira and Vasić, Vesna and Savić, Jasmina Z. and Bugarčić, Živadin",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "The spectrophotometric investigation of the reaction of [Pd(dien)Cl]+ with amino acids, Spektrofotometrijsko ispitivanje reakcije [Pd(dien)Cl]+ sa amino kiselinama",
volume = "52",
number = "4",
pages = "506-507",
url = "https://hdl.handle.net/21.15107/rcub_farfar_384"
}

Čakar, M., Vasić, V., Savić, J. Z.,& Bugarčić, Ž.. (2002). The spectrophotometric investigation of the reaction of [Pd(dien)Cl]+ with amino acids. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 506-507.
https://hdl.handle.net/21.15107/rcub_farfar_384

Čakar M, Vasić V, Savić JZ, Bugarčić Ž. The spectrophotometric investigation of the reaction of [Pd(dien)Cl]+ with amino acids. in Arhiv za farmaciju. 2002;52(4):506-507.
https://hdl.handle.net/21.15107/rcub_farfar_384 .

Čakar, Mira, Vasić, Vesna, Savić, Jasmina Z., Bugarčić, Živadin, "The spectrophotometric investigation of the reaction of [Pd(dien)Cl]+ with amino acids" in Arhiv za farmaciju, 52, no. 4 (2002):506-507,
https://hdl.handle.net/21.15107/rcub_farfar_384 .

TY  - JOUR
AU  - Joksić, Gordana
AU  - Stanković, M
AU  - Vasić, Vesna
AU  - Čakar, Mira
AU  - Jokanović, M
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/243
AB  - Cytotoxic effects of the antiviremic drug ribavirin (1-beta -D-ribofuranosyl-1,2,4-triazole-3-carboxamide) were evaluated in vitro measuring micronucleus formation and cell proliferation kinetics in whole blood cultures employing cytokinesis block (CB) micronucleus test. The cells were exposed to ribavirin doses ranging from 0.05-0.65 mu mol/ml at three different incubation times. The frequency of micronuclei in treated samples demonstrated relatively low ability of ribavirin to induce micronuclei. However, the lowest concentration of ribavirin markedly changed the frequency of mononucleated and multinucleated cells, particularly binucleated ones, which declined significantly. The decline in the frequency of binucleate cells was followed with accumulation of greater number of mononucleate cells. Decreased proliferation potential of lymphocytes treated with ribavirin indicates that cells are arrested prior to metaphase. The present investigation showed that ribavirin is capable to induce a delay in cellular proliferation at all the doses assayed. The study demonstrated that CB micronucleus assay is simple and rapid method that can be used to assess toxic effect of drugs in vitro.
PB  - Slovak Academic Press Ltd, Bratislava
T2  - Neoplasma
T1  - Influence of ribavirin on the micronucleus formation and in vitro proliferation of human lymphocytes
VL  - 47
IS  - 5
SP  - 283
EP  - 287
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2383
ER  - 

@article{
author = "Joksić, Gordana and Stanković, M and Vasić, Vesna and Čakar, Mira and Jokanović, M",
year = "2000",
abstract = "Cytotoxic effects of the antiviremic drug ribavirin (1-beta -D-ribofuranosyl-1,2,4-triazole-3-carboxamide) were evaluated in vitro measuring micronucleus formation and cell proliferation kinetics in whole blood cultures employing cytokinesis block (CB) micronucleus test. The cells were exposed to ribavirin doses ranging from 0.05-0.65 mu mol/ml at three different incubation times. The frequency of micronuclei in treated samples demonstrated relatively low ability of ribavirin to induce micronuclei. However, the lowest concentration of ribavirin markedly changed the frequency of mononucleated and multinucleated cells, particularly binucleated ones, which declined significantly. The decline in the frequency of binucleate cells was followed with accumulation of greater number of mononucleate cells. Decreased proliferation potential of lymphocytes treated with ribavirin indicates that cells are arrested prior to metaphase. The present investigation showed that ribavirin is capable to induce a delay in cellular proliferation at all the doses assayed. The study demonstrated that CB micronucleus assay is simple and rapid method that can be used to assess toxic effect of drugs in vitro.",
publisher = "Slovak Academic Press Ltd, Bratislava",
journal = "Neoplasma",
title = "Influence of ribavirin on the micronucleus formation and in vitro proliferation of human lymphocytes",
volume = "47",
number = "5",
pages = "283-287",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2383"
}

Joksić, G., Stanković, M., Vasić, V., Čakar, M.,& Jokanović, M.. (2000). Influence of ribavirin on the micronucleus formation and in vitro proliferation of human lymphocytes. in Neoplasma
Slovak Academic Press Ltd, Bratislava., 47(5), 283-287.
https://hdl.handle.net/21.15107/rcub_vinar_2383

Joksić G, Stanković M, Vasić V, Čakar M, Jokanović M. Influence of ribavirin on the micronucleus formation and in vitro proliferation of human lymphocytes. in Neoplasma. 2000;47(5):283-287.
https://hdl.handle.net/21.15107/rcub_vinar_2383 .

Joksić, Gordana, Stanković, M, Vasić, Vesna, Čakar, Mira, Jokanović, M, "Influence of ribavirin on the micronucleus formation and in vitro proliferation of human lymphocytes" in Neoplasma, 47, no. 5 (2000):283-287,
https://hdl.handle.net/21.15107/rcub_vinar_2383 .