TY  - JOUR
AU  - Rašić, Jelena
AU  - Ivanović, Nevena
AU  - Anđelković, Marija
AU  - Nedeljković, Ivana
AU  - Nikolić, Ivan
AU  - Stojanović, Sava
AU  - Ristić-Medić, Danijela
AU  - Takić, Marija
AU  - Đorđević, Brižta
AU  - Dikić, Nenad
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3972
AB  - The aim of this study was to determine the ergogenic effects and the safety profile of a one-component higenamine supplement in female recreational athletes. Twelve recreational female basketball players (age 29–41 years, oxygen consumption (VO2max) > 30 ml⋅kg–1⋅min–1, with training > 5 h wk–1) were randomized either to the higenamine group, or to the placebo group for 3 weeks. In order to determine ergogenic effects and safety profile of higenamine administration, we assessed the following variables before and after 3 weeks of supplementation: anthropometric parameters, resting metabolic rate (RMR), exercise testing variables, serum free fatty acids (FFAs), blood pressure, enzyme activity, urea, lipid profile, and complete blood count. There were no differences between groups in anthropometric parameters, including basal metabolic rate (BMR), RMR and body fat [p = 0.706 (Cohen’s d 0.223), p = 0.169 (Cohen’s d 0.857), and p = 0.223 (Cohen’s d 0.750), respectively], FFAs [0.43 ± 0.03 vs. 0.54 ± 0.23, p = 0.206 (Cohen’s d 0.540)], neither significant differences in cardiopulmonary parameters after the intervention period. Furthermore, all measured outcome variables in the safety assessment were not significant, with values remaining stable during the intervention period for participants in both groups. This is the first study to document the effects and the safety profile of higenamine-based dietary supplements at a specified dose in female recreational athletes. Our data indicate that 21-day of supplementation with 75 mg higenamine would not result in improving cardiopulmonary exercise fitness and weight loss in female recreational athletes. Moreover, supplementation with 75 mg higenamine is safe and well-tolerated in younger recreational female athletes.
PB  - Frontiers Media S.A.
T2  - Frontiers in Psychology
T1  - Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial
VL  - 12
DO  - 10.3389/fpsyg.2021.633110
ER  - 

@article{
author = "Rašić, Jelena and Ivanović, Nevena and Anđelković, Marija and Nedeljković, Ivana and Nikolić, Ivan and Stojanović, Sava and Ristić-Medić, Danijela and Takić, Marija and Đorđević, Brižta and Dikić, Nenad",
year = "2021",
abstract = "The aim of this study was to determine the ergogenic effects and the safety profile of a one-component higenamine supplement in female recreational athletes. Twelve recreational female basketball players (age 29–41 years, oxygen consumption (VO2max) > 30 ml⋅kg–1⋅min–1, with training > 5 h wk–1) were randomized either to the higenamine group, or to the placebo group for 3 weeks. In order to determine ergogenic effects and safety profile of higenamine administration, we assessed the following variables before and after 3 weeks of supplementation: anthropometric parameters, resting metabolic rate (RMR), exercise testing variables, serum free fatty acids (FFAs), blood pressure, enzyme activity, urea, lipid profile, and complete blood count. There were no differences between groups in anthropometric parameters, including basal metabolic rate (BMR), RMR and body fat [p = 0.706 (Cohen’s d 0.223), p = 0.169 (Cohen’s d 0.857), and p = 0.223 (Cohen’s d 0.750), respectively], FFAs [0.43 ± 0.03 vs. 0.54 ± 0.23, p = 0.206 (Cohen’s d 0.540)], neither significant differences in cardiopulmonary parameters after the intervention period. Furthermore, all measured outcome variables in the safety assessment were not significant, with values remaining stable during the intervention period for participants in both groups. This is the first study to document the effects and the safety profile of higenamine-based dietary supplements at a specified dose in female recreational athletes. Our data indicate that 21-day of supplementation with 75 mg higenamine would not result in improving cardiopulmonary exercise fitness and weight loss in female recreational athletes. Moreover, supplementation with 75 mg higenamine is safe and well-tolerated in younger recreational female athletes.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Psychology",
title = "Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial",
volume = "12",
doi = "10.3389/fpsyg.2021.633110"
}

Rašić, J., Ivanović, N., Anđelković, M., Nedeljković, I., Nikolić, I., Stojanović, S., Ristić-Medić, D., Takić, M., Đorđević, B.,& Dikić, N.. (2021). Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial. in Frontiers in Psychology
Frontiers Media S.A.., 12.
https://doi.org/10.3389/fpsyg.2021.633110

Rašić J, Ivanović N, Anđelković M, Nedeljković I, Nikolić I, Stojanović S, Ristić-Medić D, Takić M, Đorđević B, Dikić N. Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial. in Frontiers in Psychology. 2021;12.
doi:10.3389/fpsyg.2021.633110 .

Rašić, Jelena, Ivanović, Nevena, Anđelković, Marija, Nedeljković, Ivana, Nikolić, Ivan, Stojanović, Sava, Ristić-Medić, Danijela, Takić, Marija, Đorđević, Brižta, Dikić, Nenad, "Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial" in Frontiers in Psychology, 12 (2021),
https://doi.org/10.3389/fpsyg.2021.633110 . .

TY  - JOUR
AU  - Michalickova, Danica
AU  - Kotur-Stevuljević, Jelena
AU  - Miljković, Milica
AU  - Dikić, Nenad
AU  - Kostić-Vučićević, Marija
AU  - Anđelković, Marija
AU  - Koricanac, Vladimir
AU  - Đorđević, Brižita
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3201
AB  - A randomized, double-blind, placebo-controlled study was conducted, in order to evaluate if Lactobacillus helveticus Lafti (R) L10 (Lallemand Health Solutions, Montreal, Canada) supplementation during three months could influence oxidative markers in the population of elite athletes: triathletes, cyclists and endurance athletes. Twenty-two elite athletes were randomized to either placebo (n = 12) or probiotic (n = 10) groups. The probiotic group received 2x1010 colony forming units of Lafti (R) L10. Before and after the supplementation serum samples were collected. Markers of oxidative stress and anti-oxidative defense: superoxide dismutase (SOD), paraoxonase (PON), advanced oxidation protein products (AOPP), malondialdehyde (MDA), total antioxidant status, total oxidant status, prooxidant-antioxidant balance, oxidative stress index, bilirubin, uric acid and albumin were determined in serum. Parameters of lipid status, as well as susceptibility to copper-induced oxidation of LDL particles in vitro were also determined. There was a significant interaction effect for MDA (p = 0.039), with a decrease in MDA in the probiotic group only (p = 0.049). There was a significant interaction effect for AOPP (p = 0.037), with a significant decrease in the probiotic group (p = 0.045). Interaction effect for SOD was approaching to formal significance (p = 0.108) and the post-hoc test showed a significant decrease in the probiotic group (p = 0.041) only. A significant correlation between AOPP and SOD (p = 0.012, r = -0.40) was found in the probiotic group at the end of the study. PON1 activity was decreased in both the probiotic (p = 0.032) and placebo group (p = 0.035). No significant changes in the remainder of the evaluated parameters were noted. In conclusion, probiotic strain Lafti (R) L10 exerts certain antioxidant potential, but further research is needed.
PB  - De Gruyter Poland Sp Zoo, Warsaw
T2  - Journal of Human Kinetics
T1  - Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant-Antioxidant Balance in Elite Athletes: A Double-Blind Randomized Placebo-Controlled Study
VL  - 64
IS  - 1
SP  - 111
EP  - 122
DO  - 10.1515/hukin-2017-0203
ER  - 

@article{
author = "Michalickova, Danica and Kotur-Stevuljević, Jelena and Miljković, Milica and Dikić, Nenad and Kostić-Vučićević, Marija and Anđelković, Marija and Koricanac, Vladimir and Đorđević, Brižita",
year = "2018",
abstract = "A randomized, double-blind, placebo-controlled study was conducted, in order to evaluate if Lactobacillus helveticus Lafti (R) L10 (Lallemand Health Solutions, Montreal, Canada) supplementation during three months could influence oxidative markers in the population of elite athletes: triathletes, cyclists and endurance athletes. Twenty-two elite athletes were randomized to either placebo (n = 12) or probiotic (n = 10) groups. The probiotic group received 2x1010 colony forming units of Lafti (R) L10. Before and after the supplementation serum samples were collected. Markers of oxidative stress and anti-oxidative defense: superoxide dismutase (SOD), paraoxonase (PON), advanced oxidation protein products (AOPP), malondialdehyde (MDA), total antioxidant status, total oxidant status, prooxidant-antioxidant balance, oxidative stress index, bilirubin, uric acid and albumin were determined in serum. Parameters of lipid status, as well as susceptibility to copper-induced oxidation of LDL particles in vitro were also determined. There was a significant interaction effect for MDA (p = 0.039), with a decrease in MDA in the probiotic group only (p = 0.049). There was a significant interaction effect for AOPP (p = 0.037), with a significant decrease in the probiotic group (p = 0.045). Interaction effect for SOD was approaching to formal significance (p = 0.108) and the post-hoc test showed a significant decrease in the probiotic group (p = 0.041) only. A significant correlation between AOPP and SOD (p = 0.012, r = -0.40) was found in the probiotic group at the end of the study. PON1 activity was decreased in both the probiotic (p = 0.032) and placebo group (p = 0.035). No significant changes in the remainder of the evaluated parameters were noted. In conclusion, probiotic strain Lafti (R) L10 exerts certain antioxidant potential, but further research is needed.",
publisher = "De Gruyter Poland Sp Zoo, Warsaw",
journal = "Journal of Human Kinetics",
title = "Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant-Antioxidant Balance in Elite Athletes: A Double-Blind Randomized Placebo-Controlled Study",
volume = "64",
number = "1",
pages = "111-122",
doi = "10.1515/hukin-2017-0203"
}

Michalickova, D., Kotur-Stevuljević, J., Miljković, M., Dikić, N., Kostić-Vučićević, M., Anđelković, M., Koricanac, V.,& Đorđević, B.. (2018). Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant-Antioxidant Balance in Elite Athletes: A Double-Blind Randomized Placebo-Controlled Study. in Journal of Human Kinetics
De Gruyter Poland Sp Zoo, Warsaw., 64(1), 111-122.
https://doi.org/10.1515/hukin-2017-0203

Michalickova D, Kotur-Stevuljević J, Miljković M, Dikić N, Kostić-Vučićević M, Anđelković M, Koricanac V, Đorđević B. Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant-Antioxidant Balance in Elite Athletes: A Double-Blind Randomized Placebo-Controlled Study. in Journal of Human Kinetics. 2018;64(1):111-122.
doi:10.1515/hukin-2017-0203 .

Michalickova, Danica, Kotur-Stevuljević, Jelena, Miljković, Milica, Dikić, Nenad, Kostić-Vučićević, Marija, Anđelković, Marija, Koricanac, Vladimir, Đorđević, Brižita, "Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant-Antioxidant Balance in Elite Athletes: A Double-Blind Randomized Placebo-Controlled Study" in Journal of Human Kinetics, 64, no. 1 (2018):111-122,
https://doi.org/10.1515/hukin-2017-0203 . .

TY  - JOUR
AU  - Forsdahl, Guro
AU  - Jančić-Stojanović, Biljana
AU  - Anđelković, Marija
AU  - Dikić, Nenad
AU  - Geisendorfer, Tomas
AU  - Jeitler, Veronika
AU  - Gmeiner, Gunter
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3044
AB  - Meldonium is a drug exhibiting cardioprotective and anti-ischemic effects. Due to its potential performance-enhancing benefit in sports, meldonium was added to the World Anti-Doping Agency list of prohibited substances in 2016. Since then, a high number of adverse analytical findings reported on meldonium has questioned meldonium's detection time in urine. Hence, the objective of the current study was to characterize the pharmacokinetic urinary excretion pattern of meldonium when administered as multiple intravenous injections. Three injections of 250 mg meldonium were given over a time period of five days to six healthy volunteers and urine samples were collected for eight months after the last injection of the drug. For the quantification of meldonium in urine, a liquid chromatography-tandem mass spectrometry method was fully validated according to the World Anti-Doping Agency guidelines in terms of specificity, matrix interferences, intra- and inter-day precision, accuracy, carry-over, robustness, linearity, limit of detection, and limit of quantification. The assay was successfully applied to the pharmacokinetic study. A three-compartment model was found to best describe the pharmacokinetics of meldonium with average alpha, beta, and gamma half-lives of 1.4 h, 9.4 h, and 655 h, respectively. The detection time in urine varied between 94 and 162 days.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Urinary excretion studies of meldonium after multidose parenteral application
VL  - 161
SP  - 289
EP  - 295
DO  - 10.1016/j.jpba.2018.08.053
ER  - 

@article{
author = "Forsdahl, Guro and Jančić-Stojanović, Biljana and Anđelković, Marija and Dikić, Nenad and Geisendorfer, Tomas and Jeitler, Veronika and Gmeiner, Gunter",
year = "2018",
abstract = "Meldonium is a drug exhibiting cardioprotective and anti-ischemic effects. Due to its potential performance-enhancing benefit in sports, meldonium was added to the World Anti-Doping Agency list of prohibited substances in 2016. Since then, a high number of adverse analytical findings reported on meldonium has questioned meldonium's detection time in urine. Hence, the objective of the current study was to characterize the pharmacokinetic urinary excretion pattern of meldonium when administered as multiple intravenous injections. Three injections of 250 mg meldonium were given over a time period of five days to six healthy volunteers and urine samples were collected for eight months after the last injection of the drug. For the quantification of meldonium in urine, a liquid chromatography-tandem mass spectrometry method was fully validated according to the World Anti-Doping Agency guidelines in terms of specificity, matrix interferences, intra- and inter-day precision, accuracy, carry-over, robustness, linearity, limit of detection, and limit of quantification. The assay was successfully applied to the pharmacokinetic study. A three-compartment model was found to best describe the pharmacokinetics of meldonium with average alpha, beta, and gamma half-lives of 1.4 h, 9.4 h, and 655 h, respectively. The detection time in urine varied between 94 and 162 days.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Urinary excretion studies of meldonium after multidose parenteral application",
volume = "161",
pages = "289-295",
doi = "10.1016/j.jpba.2018.08.053"
}

Forsdahl, G., Jančić-Stojanović, B., Anđelković, M., Dikić, N., Geisendorfer, T., Jeitler, V.,& Gmeiner, G.. (2018). Urinary excretion studies of meldonium after multidose parenteral application. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science BV, Amsterdam., 161, 289-295.
https://doi.org/10.1016/j.jpba.2018.08.053

Forsdahl G, Jančić-Stojanović B, Anđelković M, Dikić N, Geisendorfer T, Jeitler V, Gmeiner G. Urinary excretion studies of meldonium after multidose parenteral application. in Journal of Pharmaceutical and Biomedical Analysis. 2018;161:289-295.
doi:10.1016/j.jpba.2018.08.053 .

Forsdahl, Guro, Jančić-Stojanović, Biljana, Anđelković, Marija, Dikić, Nenad, Geisendorfer, Tomas, Jeitler, Veronika, Gmeiner, Gunter, "Urinary excretion studies of meldonium after multidose parenteral application" in Journal of Pharmaceutical and Biomedical Analysis, 161 (2018):289-295,
https://doi.org/10.1016/j.jpba.2018.08.053 . .

TY  - CONF
AU  - Stanković, Ivan
AU  - Michalickova, Danica
AU  - Minić, Rajna
AU  - Kotur-Stevuljević, Jelena
AU  - Miljković, Milica
AU  - Kostić-Vučićević, Marija
AU  - Dikić, Nenad
AU  - Anđelković, Marija
AU  - Baralić, Ivana
AU  - Ivanović, Nevena
AU  - Đorđević, Brižita
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2888
PB  - Lippincott Williams & Wilkins, Philadelphia
C3  - Medicine and Science in Sports and Exercise
T1  - Changes In Parameters Of Immunological And Oxidative Status In Elite Athletes During Winter
VL  - 49
IS  - 5
SP  - 457
EP  - 457
DO  - 10.1249/01.mss.0000518140.98604.f5
ER  - 

@conference{
author = "Stanković, Ivan and Michalickova, Danica and Minić, Rajna and Kotur-Stevuljević, Jelena and Miljković, Milica and Kostić-Vučićević, Marija and Dikić, Nenad and Anđelković, Marija and Baralić, Ivana and Ivanović, Nevena and Đorđević, Brižita",
year = "2017",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Medicine and Science in Sports and Exercise",
title = "Changes In Parameters Of Immunological And Oxidative Status In Elite Athletes During Winter",
volume = "49",
number = "5",
pages = "457-457",
doi = "10.1249/01.mss.0000518140.98604.f5"
}

Stanković, I., Michalickova, D., Minić, R., Kotur-Stevuljević, J., Miljković, M., Kostić-Vučićević, M., Dikić, N., Anđelković, M., Baralić, I., Ivanović, N.,& Đorđević, B.. (2017). Changes In Parameters Of Immunological And Oxidative Status In Elite Athletes During Winter. in Medicine and Science in Sports and Exercise
Lippincott Williams & Wilkins, Philadelphia., 49(5), 457-457.
https://doi.org/10.1249/01.mss.0000518140.98604.f5

Stanković I, Michalickova D, Minić R, Kotur-Stevuljević J, Miljković M, Kostić-Vučićević M, Dikić N, Anđelković M, Baralić I, Ivanović N, Đorđević B. Changes In Parameters Of Immunological And Oxidative Status In Elite Athletes During Winter. in Medicine and Science in Sports and Exercise. 2017;49(5):457-457.
doi:10.1249/01.mss.0000518140.98604.f5 .

Stanković, Ivan, Michalickova, Danica, Minić, Rajna, Kotur-Stevuljević, Jelena, Miljković, Milica, Kostić-Vučićević, Marija, Dikić, Nenad, Anđelković, Marija, Baralić, Ivana, Ivanović, Nevena, Đorđević, Brižita, "Changes In Parameters Of Immunological And Oxidative Status In Elite Athletes During Winter" in Medicine and Science in Sports and Exercise, 49, no. 5 (2017):457-457,
https://doi.org/10.1249/01.mss.0000518140.98604.f5 . .

TY  - JOUR
AU  - Michalickova, Danica
AU  - Kostić-Vučićević, Marija
AU  - Vukašinović-Vesić, Milica
AU  - Stojmenović, Tamara
AU  - Dikić, Nenad
AU  - Anđelković, Marija
AU  - Đorđević, Brižita
AU  - Tanasković, Bojana P.
AU  - Minić, Rajna
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2955
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3440
AB  - To test the influence of probiotic supplementation on humoral immune response, a double-blind, placebo-controlled trial was conducted. Thirty athletes (24 males and 6 females, females: (V)over dotO(2)max 38.2 +/- 4.9 ml.kg(-1).min(-1), age 23.2 +/- 1.4 years; males: (V)over dotO(2)max 57.5 +/- 9.2 ml.kg(-1).min(-1), age 24.0 +/- 2.4 years, mean +/- SD) were randomized either to the probiotic group (Lactobacillus helveticus Lafti L10, 2 x 10(10) colony-forming units) or to the placebo group. Serum and saliva samples were collected at the baseline and after 14 weeks. Total and specific antibacterial antibody levels of IgM, IgG, and IgA classes were determined for different bacteria in the serum, and in saliva, total and specific antibacterial IgA levels were examined. Total IgM was elevated in both probiotic (18%, 15-20%; mean, 90% confidence interval; p = 0.02) and placebo group (35%, 22-47%; p = 0.02), without observed differences in changes between the groups. No significant changes in IgM levels specific for tested bacteria were found. Total IgG level was constant in both groups. A significant (16%, 22.8 to 35%, p = 0.04) reduction of anti-Enterococcus faecalis IgG was noted in the placebo group, in comparison with the probiotic group. There was a substantial decrease in total IgA level in the placebo group, when measured either in serum (15%, 12-18%, p = 0.04) or in saliva (35%, -1.4 to 53%, p = 0.03). Significantly reduced levels of serum anti-lactic acid bacteria IgA antibodies in the placebo group compared with the probiotic group were detected for Lactobacillus rhamnosus LA68 (24%, 5.8-42%, p = 0.02) and for L. rhamnosus LB64 (15%, 2.7-27%, p = 0.02). Probiotic administration could have beneficial effects on systemic humoral and mucosal immune responses.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of Strength and Conditioning Research
T1  - Lactobacillus helveticus lafti L10 supplementation modulates mucosal and humoral immunity in elite athletes: A randomized, double-blind, placebo-controlled trial
VL  - 31
IS  - 1
SP  - 62
EP  - 70
DO  - 10.1519/JSC.0000000000001456
ER  - 

@article{
author = "Michalickova, Danica and Kostić-Vučićević, Marija and Vukašinović-Vesić, Milica and Stojmenović, Tamara and Dikić, Nenad and Anđelković, Marija and Đorđević, Brižita and Tanasković, Bojana P. and Minić, Rajna",
year = "2017",
abstract = "To test the influence of probiotic supplementation on humoral immune response, a double-blind, placebo-controlled trial was conducted. Thirty athletes (24 males and 6 females, females: (V)over dotO(2)max 38.2 +/- 4.9 ml.kg(-1).min(-1), age 23.2 +/- 1.4 years; males: (V)over dotO(2)max 57.5 +/- 9.2 ml.kg(-1).min(-1), age 24.0 +/- 2.4 years, mean +/- SD) were randomized either to the probiotic group (Lactobacillus helveticus Lafti L10, 2 x 10(10) colony-forming units) or to the placebo group. Serum and saliva samples were collected at the baseline and after 14 weeks. Total and specific antibacterial antibody levels of IgM, IgG, and IgA classes were determined for different bacteria in the serum, and in saliva, total and specific antibacterial IgA levels were examined. Total IgM was elevated in both probiotic (18%, 15-20%; mean, 90% confidence interval; p = 0.02) and placebo group (35%, 22-47%; p = 0.02), without observed differences in changes between the groups. No significant changes in IgM levels specific for tested bacteria were found. Total IgG level was constant in both groups. A significant (16%, 22.8 to 35%, p = 0.04) reduction of anti-Enterococcus faecalis IgG was noted in the placebo group, in comparison with the probiotic group. There was a substantial decrease in total IgA level in the placebo group, when measured either in serum (15%, 12-18%, p = 0.04) or in saliva (35%, -1.4 to 53%, p = 0.03). Significantly reduced levels of serum anti-lactic acid bacteria IgA antibodies in the placebo group compared with the probiotic group were detected for Lactobacillus rhamnosus LA68 (24%, 5.8-42%, p = 0.02) and for L. rhamnosus LB64 (15%, 2.7-27%, p = 0.02). Probiotic administration could have beneficial effects on systemic humoral and mucosal immune responses.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Strength and Conditioning Research",
title = "Lactobacillus helveticus lafti L10 supplementation modulates mucosal and humoral immunity in elite athletes: A randomized, double-blind, placebo-controlled trial",
volume = "31",
number = "1",
pages = "62-70",
doi = "10.1519/JSC.0000000000001456"
}

Michalickova, D., Kostić-Vučićević, M., Vukašinović-Vesić, M., Stojmenović, T., Dikić, N., Anđelković, M., Đorđević, B., Tanasković, B. P.,& Minić, R.. (2017). Lactobacillus helveticus lafti L10 supplementation modulates mucosal and humoral immunity in elite athletes: A randomized, double-blind, placebo-controlled trial. in Journal of Strength and Conditioning Research
Lippincott Williams & Wilkins, Philadelphia., 31(1), 62-70.
https://doi.org/10.1519/JSC.0000000000001456

Michalickova D, Kostić-Vučićević M, Vukašinović-Vesić M, Stojmenović T, Dikić N, Anđelković M, Đorđević B, Tanasković BP, Minić R. Lactobacillus helveticus lafti L10 supplementation modulates mucosal and humoral immunity in elite athletes: A randomized, double-blind, placebo-controlled trial. in Journal of Strength and Conditioning Research. 2017;31(1):62-70.
doi:10.1519/JSC.0000000000001456 .

Michalickova, Danica, Kostić-Vučićević, Marija, Vukašinović-Vesić, Milica, Stojmenović, Tamara, Dikić, Nenad, Anđelković, Marija, Đorđević, Brižita, Tanasković, Bojana P., Minić, Rajna, "Lactobacillus helveticus lafti L10 supplementation modulates mucosal and humoral immunity in elite athletes: A randomized, double-blind, placebo-controlled trial" in Journal of Strength and Conditioning Research, 31, no. 1 (2017):62-70,
https://doi.org/10.1519/JSC.0000000000001456 . .

TY  - JOUR
AU  - Michalickova, Danica
AU  - Kostić-Vučićević, Marija
AU  - Vukašinović-Vesić, Milica
AU  - Stojmenović, Tamara
AU  - Dikić, Nenad
AU  - Anđelković, Marija
AU  - Đorđević, Brižita
AU  - Tanasković, Bojana P.
AU  - Minić, Rajna
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2955
AB  - To test the influence of probiotic supplementation on humoral immune response, a double-blind, placebo-controlled trial was conducted. Thirty athletes (24 males and 6 females, females: (V)over dotO(2)max 38.2 +/- 4.9 ml.kg(-1).min(-1), age 23.2 +/- 1.4 years; males: (V)over dotO(2)max 57.5 +/- 9.2 ml.kg(-1).min(-1), age 24.0 +/- 2.4 years, mean +/- SD) were randomized either to the probiotic group (Lactobacillus helveticus Lafti L10, 2 x 10(10) colony-forming units) or to the placebo group. Serum and saliva samples were collected at the baseline and after 14 weeks. Total and specific antibacterial antibody levels of IgM, IgG, and IgA classes were determined for different bacteria in the serum, and in saliva, total and specific antibacterial IgA levels were examined. Total IgM was elevated in both probiotic (18%, 15-20%; mean, 90% confidence interval; p = 0.02) and placebo group (35%, 22-47%; p = 0.02), without observed differences in changes between the groups. No significant changes in IgM levels specific for tested bacteria were found. Total IgG level was constant in both groups. A significant (16%, 22.8 to 35%, p = 0.04) reduction of anti-Enterococcus faecalis IgG was noted in the placebo group, in comparison with the probiotic group. There was a substantial decrease in total IgA level in the placebo group, when measured either in serum (15%, 12-18%, p = 0.04) or in saliva (35%, -1.4 to 53%, p = 0.03). Significantly reduced levels of serum anti-lactic acid bacteria IgA antibodies in the placebo group compared with the probiotic group were detected for Lactobacillus rhamnosus LA68 (24%, 5.8-42%, p = 0.02) and for L. rhamnosus LB64 (15%, 2.7-27%, p = 0.02). Probiotic administration could have beneficial effects on systemic humoral and mucosal immune responses.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of Strength and Conditioning Research
T1  - Lactobacillus helveticus lafti L10 supplementation modulates mucosal and humoral immunity in elite athletes: A randomized, double-blind, placebo-controlled trial
VL  - 31
IS  - 1
SP  - 62
EP  - 70
DO  - 10.1519/JSC.0000000000001456
ER  - 

@article{
author = "Michalickova, Danica and Kostić-Vučićević, Marija and Vukašinović-Vesić, Milica and Stojmenović, Tamara and Dikić, Nenad and Anđelković, Marija and Đorđević, Brižita and Tanasković, Bojana P. and Minić, Rajna",
year = "2017",
abstract = "To test the influence of probiotic supplementation on humoral immune response, a double-blind, placebo-controlled trial was conducted. Thirty athletes (24 males and 6 females, females: (V)over dotO(2)max 38.2 +/- 4.9 ml.kg(-1).min(-1), age 23.2 +/- 1.4 years; males: (V)over dotO(2)max 57.5 +/- 9.2 ml.kg(-1).min(-1), age 24.0 +/- 2.4 years, mean +/- SD) were randomized either to the probiotic group (Lactobacillus helveticus Lafti L10, 2 x 10(10) colony-forming units) or to the placebo group. Serum and saliva samples were collected at the baseline and after 14 weeks. Total and specific antibacterial antibody levels of IgM, IgG, and IgA classes were determined for different bacteria in the serum, and in saliva, total and specific antibacterial IgA levels were examined. Total IgM was elevated in both probiotic (18%, 15-20%; mean, 90% confidence interval; p = 0.02) and placebo group (35%, 22-47%; p = 0.02), without observed differences in changes between the groups. No significant changes in IgM levels specific for tested bacteria were found. Total IgG level was constant in both groups. A significant (16%, 22.8 to 35%, p = 0.04) reduction of anti-Enterococcus faecalis IgG was noted in the placebo group, in comparison with the probiotic group. There was a substantial decrease in total IgA level in the placebo group, when measured either in serum (15%, 12-18%, p = 0.04) or in saliva (35%, -1.4 to 53%, p = 0.03). Significantly reduced levels of serum anti-lactic acid bacteria IgA antibodies in the placebo group compared with the probiotic group were detected for Lactobacillus rhamnosus LA68 (24%, 5.8-42%, p = 0.02) and for L. rhamnosus LB64 (15%, 2.7-27%, p = 0.02). Probiotic administration could have beneficial effects on systemic humoral and mucosal immune responses.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Strength and Conditioning Research",
title = "Lactobacillus helveticus lafti L10 supplementation modulates mucosal and humoral immunity in elite athletes: A randomized, double-blind, placebo-controlled trial",
volume = "31",
number = "1",
pages = "62-70",
doi = "10.1519/JSC.0000000000001456"
}

Michalickova, D., Kostić-Vučićević, M., Vukašinović-Vesić, M., Stojmenović, T., Dikić, N., Anđelković, M., Đorđević, B., Tanasković, B. P.,& Minić, R.. (2017). Lactobacillus helveticus lafti L10 supplementation modulates mucosal and humoral immunity in elite athletes: A randomized, double-blind, placebo-controlled trial. in Journal of Strength and Conditioning Research
Lippincott Williams & Wilkins, Philadelphia., 31(1), 62-70.
https://doi.org/10.1519/JSC.0000000000001456

Michalickova D, Kostić-Vučićević M, Vukašinović-Vesić M, Stojmenović T, Dikić N, Anđelković M, Đorđević B, Tanasković BP, Minić R. Lactobacillus helveticus lafti L10 supplementation modulates mucosal and humoral immunity in elite athletes: A randomized, double-blind, placebo-controlled trial. in Journal of Strength and Conditioning Research. 2017;31(1):62-70.
doi:10.1519/JSC.0000000000001456 .

Michalickova, Danica, Kostić-Vučićević, Marija, Vukašinović-Vesić, Milica, Stojmenović, Tamara, Dikić, Nenad, Anđelković, Marija, Đorđević, Brižita, Tanasković, Bojana P., Minić, Rajna, "Lactobacillus helveticus lafti L10 supplementation modulates mucosal and humoral immunity in elite athletes: A randomized, double-blind, placebo-controlled trial" in Journal of Strength and Conditioning Research, 31, no. 1 (2017):62-70,
https://doi.org/10.1519/JSC.0000000000001456 . .

TY  - JOUR
AU  - Stajić, Ana
AU  - Anđelković, Marija
AU  - Dikić, Nenad
AU  - Rasić, J.
AU  - Vukašinović-Vesić, Milica
AU  - Ivanović, D.
AU  - Jančić-Stojanović, Biljana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2869
AB  - From 1st January 2017 higenamine was added on the WADA (World Anti-doping Agency) Prohibited list under S3 group beta-2 agonists as at all times banned substance for the athletes. The main origine of higenamine (or norcoclaurine) are different plants including Nandina domestica, Aconitum carmichaelii, Asarum heterotropioides, Galium divaricatum, Annona squamosa, Nelumbo nucifera etc. Higenamine main use is related to weight loss and it could be found (un)labeled in different dietary supplements. The objective of this study was development of sensitive and reliable UHPLC/MS/MS method for determination of higenamine in various dietary supplement samples. In order to obtain high method sensitivity, hydrophilic interaction liquid chromatography (HILIC) mode was applied. Separation was carried out on UHPLC Acquity BEH HILIC analytical column (2.1 mm x 100 mm, 1.7 mu m particle size). Mobile phase consisted of 0.1% formic acid in water and acetonitrile, respectively, was mixed in ratio of 30:70, v/v. Flow rate was set at 0.2 mL min(-1). Quercetin was used as an internal standard. ESI (+) source ionization mode using multi reaction monitoring (MRM) mode was utilized and three ion transitions of higenamine were followed 272.08 -> 107.01, 272.08 -> 161.07 and 272.08 -> 77.08. Developed method was fully validated and applied for identification and quantification of higenamine in different dietary supplements. According to the results, the most of investigated supplements were free of higenamine, and on the other hand, presence of higenamine was confirmed in some samples while it was not declared on the label.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Determination of higenamine in dietary supplements by UHPLC/MS/MS method
VL  - 146
SP  - 48
EP  - 52
DO  - 10.1016/j.jpba.2017.08.017
ER  - 

@article{
author = "Stajić, Ana and Anđelković, Marija and Dikić, Nenad and Rasić, J. and Vukašinović-Vesić, Milica and Ivanović, D. and Jančić-Stojanović, Biljana",
year = "2017",
abstract = "From 1st January 2017 higenamine was added on the WADA (World Anti-doping Agency) Prohibited list under S3 group beta-2 agonists as at all times banned substance for the athletes. The main origine of higenamine (or norcoclaurine) are different plants including Nandina domestica, Aconitum carmichaelii, Asarum heterotropioides, Galium divaricatum, Annona squamosa, Nelumbo nucifera etc. Higenamine main use is related to weight loss and it could be found (un)labeled in different dietary supplements. The objective of this study was development of sensitive and reliable UHPLC/MS/MS method for determination of higenamine in various dietary supplement samples. In order to obtain high method sensitivity, hydrophilic interaction liquid chromatography (HILIC) mode was applied. Separation was carried out on UHPLC Acquity BEH HILIC analytical column (2.1 mm x 100 mm, 1.7 mu m particle size). Mobile phase consisted of 0.1% formic acid in water and acetonitrile, respectively, was mixed in ratio of 30:70, v/v. Flow rate was set at 0.2 mL min(-1). Quercetin was used as an internal standard. ESI (+) source ionization mode using multi reaction monitoring (MRM) mode was utilized and three ion transitions of higenamine were followed 272.08 -> 107.01, 272.08 -> 161.07 and 272.08 -> 77.08. Developed method was fully validated and applied for identification and quantification of higenamine in different dietary supplements. According to the results, the most of investigated supplements were free of higenamine, and on the other hand, presence of higenamine was confirmed in some samples while it was not declared on the label.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Determination of higenamine in dietary supplements by UHPLC/MS/MS method",
volume = "146",
pages = "48-52",
doi = "10.1016/j.jpba.2017.08.017"
}

Stajić, A., Anđelković, M., Dikić, N., Rasić, J., Vukašinović-Vesić, M., Ivanović, D.,& Jančić-Stojanović, B.. (2017). Determination of higenamine in dietary supplements by UHPLC/MS/MS method. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science BV, Amsterdam., 146, 48-52.
https://doi.org/10.1016/j.jpba.2017.08.017

Stajić A, Anđelković M, Dikić N, Rasić J, Vukašinović-Vesić M, Ivanović D, Jančić-Stojanović B. Determination of higenamine in dietary supplements by UHPLC/MS/MS method. in Journal of Pharmaceutical and Biomedical Analysis. 2017;146:48-52.
doi:10.1016/j.jpba.2017.08.017 .

Stajić, Ana, Anđelković, Marija, Dikić, Nenad, Rasić, J., Vukašinović-Vesić, Milica, Ivanović, D., Jančić-Stojanović, Biljana, "Determination of higenamine in dietary supplements by UHPLC/MS/MS method" in Journal of Pharmaceutical and Biomedical Analysis, 146 (2017):48-52,
https://doi.org/10.1016/j.jpba.2017.08.017 . .

TY  - CONF
AU  - Đorđević, Brižita
AU  - Marinković, Danica
AU  - Minić, Rajna
AU  - Ivanović, Nevena
AU  - Dikić, Nenad
AU  - Anđelković, Marija
AU  - Živković, Irena
AU  - Stanković, Ivan
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2651
PB  - Lippincott Williams & Wilkins, Philadelphia
C3  - Medicine and Science in Sports and Exercise
T1  - Lactobacillus Helveticus L10 Supplementation Modulates Immunity Parameters in Elite Athletes
VL  - 48
IS  - 5
SP  - 246
EP  - 246
DO  - 10.1249/01.mss.0000485740.06462.11
ER  - 

@conference{
author = "Đorđević, Brižita and Marinković, Danica and Minić, Rajna and Ivanović, Nevena and Dikić, Nenad and Anđelković, Marija and Živković, Irena and Stanković, Ivan",
year = "2016",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Medicine and Science in Sports and Exercise",
title = "Lactobacillus Helveticus L10 Supplementation Modulates Immunity Parameters in Elite Athletes",
volume = "48",
number = "5",
pages = "246-246",
doi = "10.1249/01.mss.0000485740.06462.11"
}

Đorđević, B., Marinković, D., Minić, R., Ivanović, N., Dikić, N., Anđelković, M., Živković, I.,& Stanković, I.. (2016). Lactobacillus Helveticus L10 Supplementation Modulates Immunity Parameters in Elite Athletes. in Medicine and Science in Sports and Exercise
Lippincott Williams & Wilkins, Philadelphia., 48(5), 246-246.
https://doi.org/10.1249/01.mss.0000485740.06462.11

Đorđević B, Marinković D, Minić R, Ivanović N, Dikić N, Anđelković M, Živković I, Stanković I. Lactobacillus Helveticus L10 Supplementation Modulates Immunity Parameters in Elite Athletes. in Medicine and Science in Sports and Exercise. 2016;48(5):246-246.
doi:10.1249/01.mss.0000485740.06462.11 .

Đorđević, Brižita, Marinković, Danica, Minić, Rajna, Ivanović, Nevena, Dikić, Nenad, Anđelković, Marija, Živković, Irena, Stanković, Ivan, "Lactobacillus Helveticus L10 Supplementation Modulates Immunity Parameters in Elite Athletes" in Medicine and Science in Sports and Exercise, 48, no. 5 (2016):246-246,
https://doi.org/10.1249/01.mss.0000485740.06462.11 . .

TY  - CONF
AU  - Marinković, Danica
AU  - Minić, Rajna
AU  - Dikić, Nenad
AU  - Anđelković, Marija
AU  - Vukašinović-Vesić, Milica
AU  - Kostić-Vučićević, Marija
AU  - Stojmenović, Tamara
AU  - Nikolić, Ivan
AU  - Đorđević, Brižita
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2637
PB  - Lippincott Williams & Wilkins, Philadelphia
C3  - Journal of Clinical Gastroenterology
T1  - The Effect of Lactobacillus Helveticus L10 Supplementation on Respiratory Infections and Mucosal Immunity in Elite Athletes
VL  - 50
IS  - Supplement 2
SP  - S227
EP  - S228
DO  - 10.1097/MCG.0000000000000691
ER  - 

@conference{
author = "Marinković, Danica and Minić, Rajna and Dikić, Nenad and Anđelković, Marija and Vukašinović-Vesić, Milica and Kostić-Vučićević, Marija and Stojmenović, Tamara and Nikolić, Ivan and Đorđević, Brižita",
year = "2016",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Clinical Gastroenterology",
title = "The Effect of Lactobacillus Helveticus L10 Supplementation on Respiratory Infections and Mucosal Immunity in Elite Athletes",
volume = "50",
number = "Supplement 2",
pages = "S227-S228",
doi = "10.1097/MCG.0000000000000691"
}

Marinković, D., Minić, R., Dikić, N., Anđelković, M., Vukašinović-Vesić, M., Kostić-Vučićević, M., Stojmenović, T., Nikolić, I.,& Đorđević, B.. (2016). The Effect of Lactobacillus Helveticus L10 Supplementation on Respiratory Infections and Mucosal Immunity in Elite Athletes. in Journal of Clinical Gastroenterology
Lippincott Williams & Wilkins, Philadelphia., 50(Supplement 2), S227-S228.
https://doi.org/10.1097/MCG.0000000000000691

Marinković D, Minić R, Dikić N, Anđelković M, Vukašinović-Vesić M, Kostić-Vučićević M, Stojmenović T, Nikolić I, Đorđević B. The Effect of Lactobacillus Helveticus L10 Supplementation on Respiratory Infections and Mucosal Immunity in Elite Athletes. in Journal of Clinical Gastroenterology. 2016;50(Supplement 2):S227-S228.
doi:10.1097/MCG.0000000000000691 .

Marinković, Danica, Minić, Rajna, Dikić, Nenad, Anđelković, Marija, Vukašinović-Vesić, Milica, Kostić-Vučićević, Marija, Stojmenović, Tamara, Nikolić, Ivan, Đorđević, Brižita, "The Effect of Lactobacillus Helveticus L10 Supplementation on Respiratory Infections and Mucosal Immunity in Elite Athletes" in Journal of Clinical Gastroenterology, 50, no. Supplement 2 (2016):S227-S228,
https://doi.org/10.1097/MCG.0000000000000691 . .

TY  - JOUR
AU  - Michalickova, Danica
AU  - Minić, Rajna
AU  - Dikić, Nenad
AU  - Anđelković, Marija
AU  - Kostić-Vučićević, Marija
AU  - Stojmenović, Tamara
AU  - Nikolić, Ivan
AU  - Đorđević, Brižita
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3441
AB  - A randomized, double-blind, placebo-controlled study was conducted to evaluate if Lactobacillus helveticus Lafti L10 (Lallemand Health Solutions, Montreal, Que., Canada) supplementation during 14 weeks in winter can influence the duration, severity, and incidence of upper respiratory tract illness (URTI), as well as to monitor different immune parameters in the population of elite athletes. Before and after the treatment, cardiopulmonary testing and self-rated state of moods evaluation (by Profile of Mood States questionnaire) were performed and blood samples were collected. Thirty-nine elite athletes were randomized either to the placebo (n = 19) or the probiotic (n = 20) group. The probiotic group received L. helveticus Lafti L10, 2 x 10(10) Colony Forming Units. Lafti L10 significantly shortened the URTI episode duration (7.25 +/- 2.90 vs. 10.64 +/- 4.67 days, p = 0.047) and decreased the number of symptoms in the probiotic group (4.92 +/- 1.96 vs. 6.91 +/- 1.22, p = 0.035). Severity and incidence of URTI did not differ between the treatments. There were no significant changes in leukocyte subpopulation abundance, transforming growth factor-beta serum levels, level of interleukin-10 secreted from peptidoglican stimulated peripheral blood mononuclear cells (PBMCs), interferon-gamma level secreted from concanavalin A-stimulated PBMCs or viability/proliferation of PBMCs upon antigen stimulation. Group effect for CD4+/CD8+ ratio was significant (F-[1,F-37] = 6.99, p = 0.020, eta(2) = 0.350); this difference was not significant at baseline, but was evident after 14 weeks (p = 0.02). A significant interaction effect was noted for self-rated sense of vigor (F-[1,F-37] = 11.76, p = 0.009, eta(2) = 0.595). Self-rated sense of vigor increased in the probiotic group (18.5 +/- 4.1 vs. 21.0 +/- 2.6, p = 0.012). Probiotic strain Lafti L10 can be a beneficial nutritional supplement for the reduction of URTI length in elite athletes.
PB  - Canadian Science Publishing, Nrc Research Press, Ottawa
T2  - Applied Physiology Nutrition and Metabolism
T1  - Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial
VL  - 41
IS  - 7
SP  - 782
EP  - 789
DO  - 10.1139/apnm-2015-0541
ER  - 

@article{
author = "Michalickova, Danica and Minić, Rajna and Dikić, Nenad and Anđelković, Marija and Kostić-Vučićević, Marija and Stojmenović, Tamara and Nikolić, Ivan and Đorđević, Brižita",
year = "2016",
abstract = "A randomized, double-blind, placebo-controlled study was conducted to evaluate if Lactobacillus helveticus Lafti L10 (Lallemand Health Solutions, Montreal, Que., Canada) supplementation during 14 weeks in winter can influence the duration, severity, and incidence of upper respiratory tract illness (URTI), as well as to monitor different immune parameters in the population of elite athletes. Before and after the treatment, cardiopulmonary testing and self-rated state of moods evaluation (by Profile of Mood States questionnaire) were performed and blood samples were collected. Thirty-nine elite athletes were randomized either to the placebo (n = 19) or the probiotic (n = 20) group. The probiotic group received L. helveticus Lafti L10, 2 x 10(10) Colony Forming Units. Lafti L10 significantly shortened the URTI episode duration (7.25 +/- 2.90 vs. 10.64 +/- 4.67 days, p = 0.047) and decreased the number of symptoms in the probiotic group (4.92 +/- 1.96 vs. 6.91 +/- 1.22, p = 0.035). Severity and incidence of URTI did not differ between the treatments. There were no significant changes in leukocyte subpopulation abundance, transforming growth factor-beta serum levels, level of interleukin-10 secreted from peptidoglican stimulated peripheral blood mononuclear cells (PBMCs), interferon-gamma level secreted from concanavalin A-stimulated PBMCs or viability/proliferation of PBMCs upon antigen stimulation. Group effect for CD4+/CD8+ ratio was significant (F-[1,F-37] = 6.99, p = 0.020, eta(2) = 0.350); this difference was not significant at baseline, but was evident after 14 weeks (p = 0.02). A significant interaction effect was noted for self-rated sense of vigor (F-[1,F-37] = 11.76, p = 0.009, eta(2) = 0.595). Self-rated sense of vigor increased in the probiotic group (18.5 +/- 4.1 vs. 21.0 +/- 2.6, p = 0.012). Probiotic strain Lafti L10 can be a beneficial nutritional supplement for the reduction of URTI length in elite athletes.",
publisher = "Canadian Science Publishing, Nrc Research Press, Ottawa",
journal = "Applied Physiology Nutrition and Metabolism",
title = "Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial",
volume = "41",
number = "7",
pages = "782-789",
doi = "10.1139/apnm-2015-0541"
}

Michalickova, D., Minić, R., Dikić, N., Anđelković, M., Kostić-Vučićević, M., Stojmenović, T., Nikolić, I.,& Đorđević, B.. (2016). Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial. in Applied Physiology Nutrition and Metabolism
Canadian Science Publishing, Nrc Research Press, Ottawa., 41(7), 782-789.
https://doi.org/10.1139/apnm-2015-0541

Michalickova D, Minić R, Dikić N, Anđelković M, Kostić-Vučićević M, Stojmenović T, Nikolić I, Đorđević B. Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial. in Applied Physiology Nutrition and Metabolism. 2016;41(7):782-789.
doi:10.1139/apnm-2015-0541 .

Michalickova, Danica, Minić, Rajna, Dikić, Nenad, Anđelković, Marija, Kostić-Vučićević, Marija, Stojmenović, Tamara, Nikolić, Ivan, Đorđević, Brižita, "Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial" in Applied Physiology Nutrition and Metabolism, 41, no. 7 (2016):782-789,
https://doi.org/10.1139/apnm-2015-0541 . .

TY  - JOUR
AU  - Michalickova, Danica
AU  - Minić, Rajna
AU  - Dikić, Nenad
AU  - Anđelković, Marija
AU  - Kostić-Vučićević, Marija
AU  - Stojmenović, Tamara
AU  - Nikolić, Ivan
AU  - Đorđević, Brižita
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2753
AB  - A randomized, double-blind, placebo-controlled study was conducted to evaluate if Lactobacillus helveticus Lafti L10 (Lallemand Health Solutions, Montreal, Que., Canada) supplementation during 14 weeks in winter can influence the duration, severity, and incidence of upper respiratory tract illness (URTI), as well as to monitor different immune parameters in the population of elite athletes. Before and after the treatment, cardiopulmonary testing and self-rated state of moods evaluation (by Profile of Mood States questionnaire) were performed and blood samples were collected. Thirty-nine elite athletes were randomized either to the placebo (n = 19) or the probiotic (n = 20) group. The probiotic group received L. helveticus Lafti L10, 2 x 10(10) Colony Forming Units. Lafti L10 significantly shortened the URTI episode duration (7.25 +/- 2.90 vs. 10.64 +/- 4.67 days, p = 0.047) and decreased the number of symptoms in the probiotic group (4.92 +/- 1.96 vs. 6.91 +/- 1.22, p = 0.035). Severity and incidence of URTI did not differ between the treatments. There were no significant changes in leukocyte subpopulation abundance, transforming growth factor-beta serum levels, level of interleukin-10 secreted from peptidoglican stimulated peripheral blood mononuclear cells (PBMCs), interferon-gamma level secreted from concanavalin A-stimulated PBMCs or viability/proliferation of PBMCs upon antigen stimulation. Group effect for CD4+/CD8+ ratio was significant (F-[1,F-37] = 6.99, p = 0.020, eta(2) = 0.350); this difference was not significant at baseline, but was evident after 14 weeks (p = 0.02). A significant interaction effect was noted for self-rated sense of vigor (F-[1,F-37] = 11.76, p = 0.009, eta(2) = 0.595). Self-rated sense of vigor increased in the probiotic group (18.5 +/- 4.1 vs. 21.0 +/- 2.6, p = 0.012). Probiotic strain Lafti L10 can be a beneficial nutritional supplement for the reduction of URTI length in elite athletes.
PB  - Canadian Science Publishing, Nrc Research Press, Ottawa
T2  - Applied Physiology Nutrition and Metabolism
T1  - Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial
VL  - 41
IS  - 7
SP  - 782
EP  - 789
DO  - 10.1139/apnm-2015-0541
ER  - 

@article{
author = "Michalickova, Danica and Minić, Rajna and Dikić, Nenad and Anđelković, Marija and Kostić-Vučićević, Marija and Stojmenović, Tamara and Nikolić, Ivan and Đorđević, Brižita",
year = "2016",
abstract = "A randomized, double-blind, placebo-controlled study was conducted to evaluate if Lactobacillus helveticus Lafti L10 (Lallemand Health Solutions, Montreal, Que., Canada) supplementation during 14 weeks in winter can influence the duration, severity, and incidence of upper respiratory tract illness (URTI), as well as to monitor different immune parameters in the population of elite athletes. Before and after the treatment, cardiopulmonary testing and self-rated state of moods evaluation (by Profile of Mood States questionnaire) were performed and blood samples were collected. Thirty-nine elite athletes were randomized either to the placebo (n = 19) or the probiotic (n = 20) group. The probiotic group received L. helveticus Lafti L10, 2 x 10(10) Colony Forming Units. Lafti L10 significantly shortened the URTI episode duration (7.25 +/- 2.90 vs. 10.64 +/- 4.67 days, p = 0.047) and decreased the number of symptoms in the probiotic group (4.92 +/- 1.96 vs. 6.91 +/- 1.22, p = 0.035). Severity and incidence of URTI did not differ between the treatments. There were no significant changes in leukocyte subpopulation abundance, transforming growth factor-beta serum levels, level of interleukin-10 secreted from peptidoglican stimulated peripheral blood mononuclear cells (PBMCs), interferon-gamma level secreted from concanavalin A-stimulated PBMCs or viability/proliferation of PBMCs upon antigen stimulation. Group effect for CD4+/CD8+ ratio was significant (F-[1,F-37] = 6.99, p = 0.020, eta(2) = 0.350); this difference was not significant at baseline, but was evident after 14 weeks (p = 0.02). A significant interaction effect was noted for self-rated sense of vigor (F-[1,F-37] = 11.76, p = 0.009, eta(2) = 0.595). Self-rated sense of vigor increased in the probiotic group (18.5 +/- 4.1 vs. 21.0 +/- 2.6, p = 0.012). Probiotic strain Lafti L10 can be a beneficial nutritional supplement for the reduction of URTI length in elite athletes.",
publisher = "Canadian Science Publishing, Nrc Research Press, Ottawa",
journal = "Applied Physiology Nutrition and Metabolism",
title = "Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial",
volume = "41",
number = "7",
pages = "782-789",
doi = "10.1139/apnm-2015-0541"
}

Michalickova, D., Minić, R., Dikić, N., Anđelković, M., Kostić-Vučićević, M., Stojmenović, T., Nikolić, I.,& Đorđević, B.. (2016). Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial. in Applied Physiology Nutrition and Metabolism
Canadian Science Publishing, Nrc Research Press, Ottawa., 41(7), 782-789.
https://doi.org/10.1139/apnm-2015-0541

Michalickova D, Minić R, Dikić N, Anđelković M, Kostić-Vučićević M, Stojmenović T, Nikolić I, Đorđević B. Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial. in Applied Physiology Nutrition and Metabolism. 2016;41(7):782-789.
doi:10.1139/apnm-2015-0541 .

Michalickova, Danica, Minić, Rajna, Dikić, Nenad, Anđelković, Marija, Kostić-Vučićević, Marija, Stojmenović, Tamara, Nikolić, Ivan, Đorđević, Brižita, "Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial" in Applied Physiology Nutrition and Metabolism, 41, no. 7 (2016):782-789,
https://doi.org/10.1139/apnm-2015-0541 . .

TY  - CONF
AU  - Đorđević, Brižita
AU  - Baralić, Ivana
AU  - Anđelković, Marija
AU  - Stojmenović, Tamara
AU  - Vukašinović-Vesić, Milica
AU  - Malić, Tatjana
AU  - Marinković, Danica
AU  - Dikić, Nenad
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2503
PB  - Lippincott Williams & Wilkins, Philadelphia
C3  - Medicine and Science in Sports and Exercise
T1  - The Effect Of Astaxanthin On Mucosal Immunity, Oxidative Stress And Inflammation In Soccer Players
VL  - 47
IS  - 5
SP  - 894
EP  - 894
DO  - 10.1249/01.mss.0000479161.36874.7a
ER  - 

@conference{
author = "Đorđević, Brižita and Baralić, Ivana and Anđelković, Marija and Stojmenović, Tamara and Vukašinović-Vesić, Milica and Malić, Tatjana and Marinković, Danica and Dikić, Nenad",
year = "2015",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Medicine and Science in Sports and Exercise",
title = "The Effect Of Astaxanthin On Mucosal Immunity, Oxidative Stress And Inflammation In Soccer Players",
volume = "47",
number = "5",
pages = "894-894",
doi = "10.1249/01.mss.0000479161.36874.7a"
}

Đorđević, B., Baralić, I., Anđelković, M., Stojmenović, T., Vukašinović-Vesić, M., Malić, T., Marinković, D.,& Dikić, N.. (2015). The Effect Of Astaxanthin On Mucosal Immunity, Oxidative Stress And Inflammation In Soccer Players. in Medicine and Science in Sports and Exercise
Lippincott Williams & Wilkins, Philadelphia., 47(5), 894-894.
https://doi.org/10.1249/01.mss.0000479161.36874.7a

Đorđević B, Baralić I, Anđelković M, Stojmenović T, Vukašinović-Vesić M, Malić T, Marinković D, Dikić N. The Effect Of Astaxanthin On Mucosal Immunity, Oxidative Stress And Inflammation In Soccer Players. in Medicine and Science in Sports and Exercise. 2015;47(5):894-894.
doi:10.1249/01.mss.0000479161.36874.7a .

Đorđević, Brižita, Baralić, Ivana, Anđelković, Marija, Stojmenović, Tamara, Vukašinović-Vesić, Milica, Malić, Tatjana, Marinković, Danica, Dikić, Nenad, "The Effect Of Astaxanthin On Mucosal Immunity, Oxidative Stress And Inflammation In Soccer Players" in Medicine and Science in Sports and Exercise, 47, no. 5 (2015):894-894,
https://doi.org/10.1249/01.mss.0000479161.36874.7a . .

TY  - CONF
AU  - Baralić, Ivana
AU  - Dikić, Nenad
AU  - Anđelković, Marija
AU  - Mojsilović, Željko
AU  - Jeremić-Velimirović, Tanja
AU  - Popović, Milka
AU  - Vukašinović-Vesić, Milica
AU  - Malić, Tatjana
AU  - Stojmenović, Tamara
AU  - Marinković, Danica
AU  - Đorđević, Brižita
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2494
PB  - Lippincott Williams & Wilkins, Philadelphia
C3  - Medicine and Science in Sports and Exercise
T1  - The Impact Of High Risk Situation Announcement On Psychological Stress In Special Unit Forces Members
VL  - 47
IS  - 5
SP  - 810
EP  - 810
DO  - 10.1249/01.mss.0000478951.79597.1b
ER  - 

@conference{
author = "Baralić, Ivana and Dikić, Nenad and Anđelković, Marija and Mojsilović, Željko and Jeremić-Velimirović, Tanja and Popović, Milka and Vukašinović-Vesić, Milica and Malić, Tatjana and Stojmenović, Tamara and Marinković, Danica and Đorđević, Brižita",
year = "2015",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Medicine and Science in Sports and Exercise",
title = "The Impact Of High Risk Situation Announcement On Psychological Stress In Special Unit Forces Members",
volume = "47",
number = "5",
pages = "810-810",
doi = "10.1249/01.mss.0000478951.79597.1b"
}

Baralić, I., Dikić, N., Anđelković, M., Mojsilović, Ž., Jeremić-Velimirović, T., Popović, M., Vukašinović-Vesić, M., Malić, T., Stojmenović, T., Marinković, D.,& Đorđević, B.. (2015). The Impact Of High Risk Situation Announcement On Psychological Stress In Special Unit Forces Members. in Medicine and Science in Sports and Exercise
Lippincott Williams & Wilkins, Philadelphia., 47(5), 810-810.
https://doi.org/10.1249/01.mss.0000478951.79597.1b

Baralić I, Dikić N, Anđelković M, Mojsilović Ž, Jeremić-Velimirović T, Popović M, Vukašinović-Vesić M, Malić T, Stojmenović T, Marinković D, Đorđević B. The Impact Of High Risk Situation Announcement On Psychological Stress In Special Unit Forces Members. in Medicine and Science in Sports and Exercise. 2015;47(5):810-810.
doi:10.1249/01.mss.0000478951.79597.1b .

Baralić, Ivana, Dikić, Nenad, Anđelković, Marija, Mojsilović, Željko, Jeremić-Velimirović, Tanja, Popović, Milka, Vukašinović-Vesić, Milica, Malić, Tatjana, Stojmenović, Tamara, Marinković, Danica, Đorđević, Brižita, "The Impact Of High Risk Situation Announcement On Psychological Stress In Special Unit Forces Members" in Medicine and Science in Sports and Exercise, 47, no. 5 (2015):810-810,
https://doi.org/10.1249/01.mss.0000478951.79597.1b . .

TY  - CONF
AU  - Dikić, Nenad
AU  - Walser, Sabine
AU  - Anđelković, Marija
AU  - Jovanović, Zoran
AU  - Vukašinović-Vesić, Milica
AU  - Đorđević, Brižita
AU  - Baralić, Ivana
AU  - Stojmenović, Tamara
AU  - Malić, Tatjana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2491
PB  - Lippincott Williams & Wilkins, Philadelphia
C3  - Medicine and Science in Sports and Exercise
T1  - Harm Caused By Counterfeit Medicines - The Major Problem In Sport After Doping
VL  - 47
IS  - 5
SP  - 760
EP  - 760
DO  - 10.1249/01.mss.0000478811.21279.eb
ER  - 

@conference{
author = "Dikić, Nenad and Walser, Sabine and Anđelković, Marija and Jovanović, Zoran and Vukašinović-Vesić, Milica and Đorđević, Brižita and Baralić, Ivana and Stojmenović, Tamara and Malić, Tatjana",
year = "2015",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Medicine and Science in Sports and Exercise",
title = "Harm Caused By Counterfeit Medicines - The Major Problem In Sport After Doping",
volume = "47",
number = "5",
pages = "760-760",
doi = "10.1249/01.mss.0000478811.21279.eb"
}

Dikić, N., Walser, S., Anđelković, M., Jovanović, Z., Vukašinović-Vesić, M., Đorđević, B., Baralić, I., Stojmenović, T.,& Malić, T.. (2015). Harm Caused By Counterfeit Medicines - The Major Problem In Sport After Doping. in Medicine and Science in Sports and Exercise
Lippincott Williams & Wilkins, Philadelphia., 47(5), 760-760.
https://doi.org/10.1249/01.mss.0000478811.21279.eb

Dikić N, Walser S, Anđelković M, Jovanović Z, Vukašinović-Vesić M, Đorđević B, Baralić I, Stojmenović T, Malić T. Harm Caused By Counterfeit Medicines - The Major Problem In Sport After Doping. in Medicine and Science in Sports and Exercise. 2015;47(5):760-760.
doi:10.1249/01.mss.0000478811.21279.eb .

Dikić, Nenad, Walser, Sabine, Anđelković, Marija, Jovanović, Zoran, Vukašinović-Vesić, Milica, Đorđević, Brižita, Baralić, Ivana, Stojmenović, Tamara, Malić, Tatjana, "Harm Caused By Counterfeit Medicines - The Major Problem In Sport After Doping" in Medicine and Science in Sports and Exercise, 47, no. 5 (2015):760-760,
https://doi.org/10.1249/01.mss.0000478811.21279.eb . .

TY  - CONF
AU  - Struk, Tamara
AU  - Dikić, Nenad
AU  - Anđelković, Marija
AU  - Vukašinović-Vesić, Milica
AU  - Baralić, Ivana
AU  - Malić, Tatjana
AU  - Đorđević, Brižita
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2490
PB  - Lippincott Williams & Wilkins, Philadelphia
C3  - Medicine and Science in Sports and Exercise
T1  - Impact of Basketball Training on Aerobic Capacity, Strength and Flexibility in Young Girls Over Time
VL  - 47
IS  - 5
SP  - 689
EP  - 690
DO  - 10.1249/01.mss.0000478605.03658.bb
ER  - 

@conference{
author = "Struk, Tamara and Dikić, Nenad and Anđelković, Marija and Vukašinović-Vesić, Milica and Baralić, Ivana and Malić, Tatjana and Đorđević, Brižita",
year = "2015",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Medicine and Science in Sports and Exercise",
title = "Impact of Basketball Training on Aerobic Capacity, Strength and Flexibility in Young Girls Over Time",
volume = "47",
number = "5",
pages = "689-690",
doi = "10.1249/01.mss.0000478605.03658.bb"
}

Struk, T., Dikić, N., Anđelković, M., Vukašinović-Vesić, M., Baralić, I., Malić, T.,& Đorđević, B.. (2015). Impact of Basketball Training on Aerobic Capacity, Strength and Flexibility in Young Girls Over Time. in Medicine and Science in Sports and Exercise
Lippincott Williams & Wilkins, Philadelphia., 47(5), 689-690.
https://doi.org/10.1249/01.mss.0000478605.03658.bb

Struk T, Dikić N, Anđelković M, Vukašinović-Vesić M, Baralić I, Malić T, Đorđević B. Impact of Basketball Training on Aerobic Capacity, Strength and Flexibility in Young Girls Over Time. in Medicine and Science in Sports and Exercise. 2015;47(5):689-690.
doi:10.1249/01.mss.0000478605.03658.bb .

Struk, Tamara, Dikić, Nenad, Anđelković, Marija, Vukašinović-Vesić, Milica, Baralić, Ivana, Malić, Tatjana, Đorđević, Brižita, "Impact of Basketball Training on Aerobic Capacity, Strength and Flexibility in Young Girls Over Time" in Medicine and Science in Sports and Exercise, 47, no. 5 (2015):689-690,
https://doi.org/10.1249/01.mss.0000478605.03658.bb . .

TY  - CONF
AU  - Vukašinović-Vesić, Milica
AU  - Anđelković, Marija
AU  - Dikić, Nenad
AU  - Baralić, Ivana
AU  - Stojmenović, Tamara
AU  - Malić, Tatjana
AU  - Đorđević, Brižita
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2489
PB  - Lippincott Williams & Wilkins, Philadelphia
C3  - Medicine and Science in Sports and Exercise
T1  - Pre-Game And Post-Game Hydration Status Of Young Basketball Players
VL  - 47
IS  - 5
SP  - 503
EP  - 504
DO  - 10.1249/01.mss.0000477817.33697.4f
ER  - 

@conference{
author = "Vukašinović-Vesić, Milica and Anđelković, Marija and Dikić, Nenad and Baralić, Ivana and Stojmenović, Tamara and Malić, Tatjana and Đorđević, Brižita",
year = "2015",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Medicine and Science in Sports and Exercise",
title = "Pre-Game And Post-Game Hydration Status Of Young Basketball Players",
volume = "47",
number = "5",
pages = "503-504",
doi = "10.1249/01.mss.0000477817.33697.4f"
}

Vukašinović-Vesić, M., Anđelković, M., Dikić, N., Baralić, I., Stojmenović, T., Malić, T.,& Đorđević, B.. (2015). Pre-Game And Post-Game Hydration Status Of Young Basketball Players. in Medicine and Science in Sports and Exercise
Lippincott Williams & Wilkins, Philadelphia., 47(5), 503-504.
https://doi.org/10.1249/01.mss.0000477817.33697.4f

Vukašinović-Vesić M, Anđelković M, Dikić N, Baralić I, Stojmenović T, Malić T, Đorđević B. Pre-Game And Post-Game Hydration Status Of Young Basketball Players. in Medicine and Science in Sports and Exercise. 2015;47(5):503-504.
doi:10.1249/01.mss.0000477817.33697.4f .

Vukašinović-Vesić, Milica, Anđelković, Marija, Dikić, Nenad, Baralić, Ivana, Stojmenović, Tamara, Malić, Tatjana, Đorđević, Brižita, "Pre-Game And Post-Game Hydration Status Of Young Basketball Players" in Medicine and Science in Sports and Exercise, 47, no. 5 (2015):503-504,
https://doi.org/10.1249/01.mss.0000477817.33697.4f . .

TY  - JOUR
AU  - Baralić, Ivana
AU  - Anđelković, Marija
AU  - Đorđević, Brižita
AU  - Dikić, Nenad
AU  - Radivojević, Nenad
AU  - Suzin-Živković, Violeta
AU  - Radojević-Skodrić, Sanja
AU  - Pejić, Snežana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2445
AB  - The physiologic stress induced by physical activity is reflected in immune systemperturbations, oxidative stress, muscle injury, and inflammation. We investigated the effect of astaxanthin (Asx) supplementation on salivary IgA (sIgA) and oxidative stress status in plasma, along with changes in biochemical parameters and total/differential white cell counts. Forty trained male soccer players were randomly assigned to Asx and placebo groups. Asx group was supplemented with 4mg of Asx. Saliva and blood samples were collected at the baseline and after 90 days of supplementation in preexercise conditions. We observed a rise of sIgA levels at rest after 90 days of Asx supplementation, which was accompanied with a decrease in prooxidant-antioxidant balance. The plasma muscle enzymes levels were reduced significantly by Asx supplementation and by regular training. The increase in neutrophil count and hs-CRP level was found only in placebo group, indicating a significant blunting of the systemic inflammatory response in the subjects taking Asx. This study indicates that Asx supplementation improves sIgA response and attenuates muscle damage, thus preventing inflammation induced by rigorous physical training. Our findings also point that Asx could show significant physiologic modulation in individuals with mucosal immunity impairment or under conditions of increased oxidative stress and inflammation.
PB  - Hindawi Publishing Corp, New York
T2  - Evidence-Based Complementary and Alternative Medicine
T1  - Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players
DO  - 10.1155/2015/783761
ER  - 

@article{
author = "Baralić, Ivana and Anđelković, Marija and Đorđević, Brižita and Dikić, Nenad and Radivojević, Nenad and Suzin-Živković, Violeta and Radojević-Skodrić, Sanja and Pejić, Snežana",
year = "2015",
abstract = "The physiologic stress induced by physical activity is reflected in immune systemperturbations, oxidative stress, muscle injury, and inflammation. We investigated the effect of astaxanthin (Asx) supplementation on salivary IgA (sIgA) and oxidative stress status in plasma, along with changes in biochemical parameters and total/differential white cell counts. Forty trained male soccer players were randomly assigned to Asx and placebo groups. Asx group was supplemented with 4mg of Asx. Saliva and blood samples were collected at the baseline and after 90 days of supplementation in preexercise conditions. We observed a rise of sIgA levels at rest after 90 days of Asx supplementation, which was accompanied with a decrease in prooxidant-antioxidant balance. The plasma muscle enzymes levels were reduced significantly by Asx supplementation and by regular training. The increase in neutrophil count and hs-CRP level was found only in placebo group, indicating a significant blunting of the systemic inflammatory response in the subjects taking Asx. This study indicates that Asx supplementation improves sIgA response and attenuates muscle damage, thus preventing inflammation induced by rigorous physical training. Our findings also point that Asx could show significant physiologic modulation in individuals with mucosal immunity impairment or under conditions of increased oxidative stress and inflammation.",
publisher = "Hindawi Publishing Corp, New York",
journal = "Evidence-Based Complementary and Alternative Medicine",
title = "Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players",
doi = "10.1155/2015/783761"
}

Baralić, I., Anđelković, M., Đorđević, B., Dikić, N., Radivojević, N., Suzin-Živković, V., Radojević-Skodrić, S.,& Pejić, S.. (2015). Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players. in Evidence-Based Complementary and Alternative Medicine
Hindawi Publishing Corp, New York..
https://doi.org/10.1155/2015/783761

Baralić I, Anđelković M, Đorđević B, Dikić N, Radivojević N, Suzin-Živković V, Radojević-Skodrić S, Pejić S. Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players. in Evidence-Based Complementary and Alternative Medicine. 2015;.
doi:10.1155/2015/783761 .

Baralić, Ivana, Anđelković, Marija, Đorđević, Brižita, Dikić, Nenad, Radivojević, Nenad, Suzin-Živković, Violeta, Radojević-Skodrić, Sanja, Pejić, Snežana, "Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players" in Evidence-Based Complementary and Alternative Medicine (2015),
https://doi.org/10.1155/2015/783761 . .

TY  - JOUR
AU  - Anđelković, Marija
AU  - Baralić, Ivana
AU  - Đorđević, Brižita
AU  - Kotur-Stevuljević, Jelena
AU  - Radivojević, Nenad
AU  - Dikić, Nenad
AU  - Radojević-Skodrić, Sanja
AU  - Stojković, Mirjana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2310
AB  - Background: The purpose of the present study was to report and discuss the hematological and biochemical behavior of elite soccer players, in order to get more insight in the physiological characteristics of these sportsmen and to provide trainers and sports doctors with useful indicators. Methods: Nineteen male soccer players volunteered to participate in this study. We followed the young elite soccer players during a competitive half season. Venous blood samples were collected between 9:00 and 10:00 a.m. after an overnight fast (10 h) at baseline, after 45 and 90 days and hematological and biochemical parameters were measured. Results: Hemoglobin and hematocrit levels were significantly reduced over the observational period (p lt 0.05), but erythrocyte count and iron levels remained unchanged. Bilirubin and ferritin levels significantly increased in response to regular soccer training (p lt 0.05). We observed a significant decrease in muscle enzyme plasma activity during the 90 days study period. ANOVA analysis revealed a significant increase in the leukocyte and neutrophil counts (p lt 0.05), in parallel with a significant decrease in the lymphocyte count (p lt 0.05) after the observational period of 90 days. Conclusions: Elite soccer players are characterized by significant changes in biochemical and hematological parameters over the half season, which are linked to training workload, as well as adaptation induced by the soccer training. Although the values of the measured parameters fell within the reference range, regular monitoring of the biochemical and hematological parameters is fundamental for the identification of a healthy status and related optimal performances by sport doctors and trainers and selection of a correct workload by trainers.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Hematological and Biochemical Parameters in Elite Soccer Players during A Competitive Half Season
VL  - 34
IS  - 4
SP  - 460
EP  - 466
DO  - 10.2478/jomb-2014-0057
ER  - 

@article{
author = "Anđelković, Marija and Baralić, Ivana and Đorđević, Brižita and Kotur-Stevuljević, Jelena and Radivojević, Nenad and Dikić, Nenad and Radojević-Skodrić, Sanja and Stojković, Mirjana",
year = "2015",
abstract = "Background: The purpose of the present study was to report and discuss the hematological and biochemical behavior of elite soccer players, in order to get more insight in the physiological characteristics of these sportsmen and to provide trainers and sports doctors with useful indicators. Methods: Nineteen male soccer players volunteered to participate in this study. We followed the young elite soccer players during a competitive half season. Venous blood samples were collected between 9:00 and 10:00 a.m. after an overnight fast (10 h) at baseline, after 45 and 90 days and hematological and biochemical parameters were measured. Results: Hemoglobin and hematocrit levels were significantly reduced over the observational period (p lt 0.05), but erythrocyte count and iron levels remained unchanged. Bilirubin and ferritin levels significantly increased in response to regular soccer training (p lt 0.05). We observed a significant decrease in muscle enzyme plasma activity during the 90 days study period. ANOVA analysis revealed a significant increase in the leukocyte and neutrophil counts (p lt 0.05), in parallel with a significant decrease in the lymphocyte count (p lt 0.05) after the observational period of 90 days. Conclusions: Elite soccer players are characterized by significant changes in biochemical and hematological parameters over the half season, which are linked to training workload, as well as adaptation induced by the soccer training. Although the values of the measured parameters fell within the reference range, regular monitoring of the biochemical and hematological parameters is fundamental for the identification of a healthy status and related optimal performances by sport doctors and trainers and selection of a correct workload by trainers.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Hematological and Biochemical Parameters in Elite Soccer Players during A Competitive Half Season",
volume = "34",
number = "4",
pages = "460-466",
doi = "10.2478/jomb-2014-0057"
}

Anđelković, M., Baralić, I., Đorđević, B., Kotur-Stevuljević, J., Radivojević, N., Dikić, N., Radojević-Skodrić, S.,& Stojković, M.. (2015). Hematological and Biochemical Parameters in Elite Soccer Players during A Competitive Half Season. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 34(4), 460-466.
https://doi.org/10.2478/jomb-2014-0057

Anđelković M, Baralić I, Đorđević B, Kotur-Stevuljević J, Radivojević N, Dikić N, Radojević-Skodrić S, Stojković M. Hematological and Biochemical Parameters in Elite Soccer Players during A Competitive Half Season. in Journal of Medical Biochemistry. 2015;34(4):460-466.
doi:10.2478/jomb-2014-0057 .

Anđelković, Marija, Baralić, Ivana, Đorđević, Brižita, Kotur-Stevuljević, Jelena, Radivojević, Nenad, Dikić, Nenad, Radojević-Skodrić, Sanja, Stojković, Mirjana, "Hematological and Biochemical Parameters in Elite Soccer Players during A Competitive Half Season" in Journal of Medical Biochemistry, 34, no. 4 (2015):460-466,
https://doi.org/10.2478/jomb-2014-0057 . .

TY  - JOUR
AU  - Baralić, Ivana
AU  - Đorđević, Brižita
AU  - Dikić, Nenad
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
AU  - Jelić-Ivanović, Zorana
AU  - Radivojević, Nenad
AU  - Anđelković, Marija
AU  - Pejić, Snežana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1871
AB  - The purpose of the study was to examine the effects of astaxanthin (Asx) on paraoxonase (PON1) activities and oxidative stress status in soccer players. Forty soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. Blood samples were obtained before, 45 and 90days after supplementation. PON1 activity was assessed by using two substrates: paraoxon and diazoxon. The oxidative stress biomarkers were also examined: total sulphydryl group content (-SH groups), thiobarbituric acid-reactive substances (TBARS), advanced oxidation protein products and redox balance. The significant interaction effect of supplementation and training (p lt 0.05) on PON1 activity toward paraoxon was observed. The PON1 activity toward diazoxon increased in Asx group after 90days (p lt 0.01), while there was no significant difference in P group. SH groups content rose from pre- to post-supplementation period only in Asx group (supplementation and training, p lt 0.05; training, p lt 0.01). TBARS levels decreased after 45days and increased after 90days of regular soccer training in both groups (training, p lt 0.001). Redox balance decreased significantly in response to the regular training, regardless of treatment group (training, p lt 0.001). Asx supplementation might increase total SH groups content and improve PON1 activity through protection of free thiol groups against oxidative modification. Copyright
PB  - Wiley-Blackwell, Hoboken
T2  - Phytotherapy Research
T1  - Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players
VL  - 27
IS  - 10
SP  - 1536
EP  - 1542
DO  - 10.1002/ptr.4898
ER  - 

@article{
author = "Baralić, Ivana and Đorđević, Brižita and Dikić, Nenad and Kotur-Stevuljević, Jelena and Spasić, Slavica and Jelić-Ivanović, Zorana and Radivojević, Nenad and Anđelković, Marija and Pejić, Snežana",
year = "2013",
abstract = "The purpose of the study was to examine the effects of astaxanthin (Asx) on paraoxonase (PON1) activities and oxidative stress status in soccer players. Forty soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. Blood samples were obtained before, 45 and 90days after supplementation. PON1 activity was assessed by using two substrates: paraoxon and diazoxon. The oxidative stress biomarkers were also examined: total sulphydryl group content (-SH groups), thiobarbituric acid-reactive substances (TBARS), advanced oxidation protein products and redox balance. The significant interaction effect of supplementation and training (p lt 0.05) on PON1 activity toward paraoxon was observed. The PON1 activity toward diazoxon increased in Asx group after 90days (p lt 0.01), while there was no significant difference in P group. SH groups content rose from pre- to post-supplementation period only in Asx group (supplementation and training, p lt 0.05; training, p lt 0.01). TBARS levels decreased after 45days and increased after 90days of regular soccer training in both groups (training, p lt 0.001). Redox balance decreased significantly in response to the regular training, regardless of treatment group (training, p lt 0.001). Asx supplementation might increase total SH groups content and improve PON1 activity through protection of free thiol groups against oxidative modification. Copyright",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Phytotherapy Research",
title = "Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players",
volume = "27",
number = "10",
pages = "1536-1542",
doi = "10.1002/ptr.4898"
}

Baralić, I., Đorđević, B., Dikić, N., Kotur-Stevuljević, J., Spasić, S., Jelić-Ivanović, Z., Radivojević, N., Anđelković, M.,& Pejić, S.. (2013). Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players. in Phytotherapy Research
Wiley-Blackwell, Hoboken., 27(10), 1536-1542.
https://doi.org/10.1002/ptr.4898

Baralić I, Đorđević B, Dikić N, Kotur-Stevuljević J, Spasić S, Jelić-Ivanović Z, Radivojević N, Anđelković M, Pejić S. Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players. in Phytotherapy Research. 2013;27(10):1536-1542.
doi:10.1002/ptr.4898 .

Baralić, Ivana, Đorđević, Brižita, Dikić, Nenad, Kotur-Stevuljević, Jelena, Spasić, Slavica, Jelić-Ivanović, Zorana, Radivojević, Nenad, Anđelković, Marija, Pejić, Snežana, "Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players" in Phytotherapy Research, 27, no. 10 (2013):1536-1542,
https://doi.org/10.1002/ptr.4898 . .

TY  - CONF
AU  - Baralić, Ivana
AU  - Đorđević, Brižita
AU  - Anđelković, Marija
AU  - Dikić, Nenad
AU  - Kotur-Stevuljević, Jelena
AU  - Dimitrijević, Ljiljana
AU  - Antić, T.
AU  - Vukašinović-Vesić, Milica
AU  - Radojević-Skodrić, Sanja
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1874
PB  - Karger, Basel
C3  - Annals of Nutrition and Metabolism
T1  - Effects of astaxanthin supplementation on dna stability and paraoxonase 1 activity in young soccer players
VL  - 63
IS  - Supplement 1
SP  - 772
EP  - 772
DO  - 10.1159/000354245
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1874
ER  - 

@conference{
author = "Baralić, Ivana and Đorđević, Brižita and Anđelković, Marija and Dikić, Nenad and Kotur-Stevuljević, Jelena and Dimitrijević, Ljiljana and Antić, T. and Vukašinović-Vesić, Milica and Radojević-Skodrić, Sanja",
year = "2013",
publisher = "Karger, Basel",
journal = "Annals of Nutrition and Metabolism",
title = "Effects of astaxanthin supplementation on dna stability and paraoxonase 1 activity in young soccer players",
volume = "63",
number = "Supplement 1",
pages = "772-772",
doi = "10.1159/000354245",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1874"
}

Baralić, I., Đorđević, B., Anđelković, M., Dikić, N., Kotur-Stevuljević, J., Dimitrijević, L., Antić, T., Vukašinović-Vesić, M.,& Radojević-Skodrić, S.. (2013). Effects of astaxanthin supplementation on dna stability and paraoxonase 1 activity in young soccer players. in Annals of Nutrition and Metabolism
Karger, Basel., 63(Supplement 1), 772-772.
https://doi.org/10.1159/000354245
https://hdl.handle.net/21.15107/rcub_farfar_1874

Baralić I, Đorđević B, Anđelković M, Dikić N, Kotur-Stevuljević J, Dimitrijević L, Antić T, Vukašinović-Vesić M, Radojević-Skodrić S. Effects of astaxanthin supplementation on dna stability and paraoxonase 1 activity in young soccer players. in Annals of Nutrition and Metabolism. 2013;63(Supplement 1):772-772.
doi:10.1159/000354245
https://hdl.handle.net/21.15107/rcub_farfar_1874 .

Baralić, Ivana, Đorđević, Brižita, Anđelković, Marija, Dikić, Nenad, Kotur-Stevuljević, Jelena, Dimitrijević, Ljiljana, Antić, T., Vukašinović-Vesić, Milica, Radojević-Skodrić, Sanja, "Effects of astaxanthin supplementation on dna stability and paraoxonase 1 activity in young soccer players" in Annals of Nutrition and Metabolism, 63, no. Supplement 1 (2013):772-772,
https://doi.org/10.1159/000354245 .,
https://hdl.handle.net/21.15107/rcub_farfar_1874 .

TY  - JOUR
AU  - Đorđević, Brižita
AU  - Baralić, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Ivanišević, Jasmina
AU  - Radivojević, Nenad
AU  - Anđelković, Marija
AU  - Dikić, Nenad
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1654
AB  - Aim. The purpose of the current study was to examine the effect of Astaxanthin (Asx) supplementation on muscle enzymes as indirect markers of muscle damage, oxidative stress markers and antioxidant response in elite young soccer players. Methods. Thirty-two male elite soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. After the 90 days of supplementation, the athletes performed a 2 hour acute exercise bout. Blood samples were obtained before and after 90 days of supplementation and after the exercise at the end of observational period for analysis of thiobarbituric acid-reacting substances (TBARS), advanced oxidation protein products (AOPP), superoxide anion (O-2(center dot-)), total antioxidative status (TAS), sulphydril groups (SH), superoxide-dismutase (SOD), serum creatine kinase (CK) and aspartate aminotransferase (AST). Results. TBARS and AOPP levels did not change throughout the study. Regular training significantly increased O-2(center dot-) levels (main training effect, P lt 0.01). O-2(center dot-) increased after the soccer exercise (main exercise effect, P lt 0.01), but these changes reached statistical significance only in the P group (exercise x supplementation effect, P lt 0.05). TAS levels decreased significantly post- exercise only in P group (P lt 0.01). Both Asx and P groups experienced increase in total SH groups content (by 21% and 9%, respectively) and supplementation effect was marginally significant (P=0.08). Basal SOD activity significantly decreased both in P and in Asx group by the end of the study (main training effect, P lt 0.01). All participants showed a significant decrease in basal CK and AST activities after 90 days (main training effect, P lt 0.01 and P lt 0.001, respectively). CK and AST activities in serum significantly increased as result of soccer exercise (main exercise effect, P lt 0.001 and P lt 0.01, respectively). Postexercise CK and AST levels were significantly lower in Asx group compared to P group (P lt 0.05) Conclusion. The results of the present study suggest that soccer training and soccer exercise are associated with excessive production of free radicals and oxidative stress, which might diminish antioxidant system efficiency. Supplementation with Asx could prevent exercise induced free radical production and depletion of non-enzymatic antioxidant defense in young soccer players
PB  - Edizioni Minerva Medica, Turin
T2  - Journal of Sports Medicine and Physical Fitness
T1  - Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players
VL  - 52
IS  - 4
SP  - 382
EP  - 392
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1654
ER  - 

@article{
author = "Đorđević, Brižita and Baralić, Ivana and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Ivanišević, Jasmina and Radivojević, Nenad and Anđelković, Marija and Dikić, Nenad",
year = "2012",
abstract = "Aim. The purpose of the current study was to examine the effect of Astaxanthin (Asx) supplementation on muscle enzymes as indirect markers of muscle damage, oxidative stress markers and antioxidant response in elite young soccer players. Methods. Thirty-two male elite soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. After the 90 days of supplementation, the athletes performed a 2 hour acute exercise bout. Blood samples were obtained before and after 90 days of supplementation and after the exercise at the end of observational period for analysis of thiobarbituric acid-reacting substances (TBARS), advanced oxidation protein products (AOPP), superoxide anion (O-2(center dot-)), total antioxidative status (TAS), sulphydril groups (SH), superoxide-dismutase (SOD), serum creatine kinase (CK) and aspartate aminotransferase (AST). Results. TBARS and AOPP levels did not change throughout the study. Regular training significantly increased O-2(center dot-) levels (main training effect, P lt 0.01). O-2(center dot-) increased after the soccer exercise (main exercise effect, P lt 0.01), but these changes reached statistical significance only in the P group (exercise x supplementation effect, P lt 0.05). TAS levels decreased significantly post- exercise only in P group (P lt 0.01). Both Asx and P groups experienced increase in total SH groups content (by 21% and 9%, respectively) and supplementation effect was marginally significant (P=0.08). Basal SOD activity significantly decreased both in P and in Asx group by the end of the study (main training effect, P lt 0.01). All participants showed a significant decrease in basal CK and AST activities after 90 days (main training effect, P lt 0.01 and P lt 0.001, respectively). CK and AST activities in serum significantly increased as result of soccer exercise (main exercise effect, P lt 0.001 and P lt 0.01, respectively). Postexercise CK and AST levels were significantly lower in Asx group compared to P group (P lt 0.05) Conclusion. The results of the present study suggest that soccer training and soccer exercise are associated with excessive production of free radicals and oxidative stress, which might diminish antioxidant system efficiency. Supplementation with Asx could prevent exercise induced free radical production and depletion of non-enzymatic antioxidant defense in young soccer players",
publisher = "Edizioni Minerva Medica, Turin",
journal = "Journal of Sports Medicine and Physical Fitness",
title = "Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players",
volume = "52",
number = "4",
pages = "382-392",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1654"
}

Đorđević, B., Baralić, I., Kotur-Stevuljević, J., Stefanović, A., Ivanišević, J., Radivojević, N., Anđelković, M.,& Dikić, N.. (2012). Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players. in Journal of Sports Medicine and Physical Fitness
Edizioni Minerva Medica, Turin., 52(4), 382-392.
https://hdl.handle.net/21.15107/rcub_farfar_1654

Đorđević B, Baralić I, Kotur-Stevuljević J, Stefanović A, Ivanišević J, Radivojević N, Anđelković M, Dikić N. Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players. in Journal of Sports Medicine and Physical Fitness. 2012;52(4):382-392.
https://hdl.handle.net/21.15107/rcub_farfar_1654 .

Đorđević, Brižita, Baralić, Ivana, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Ivanišević, Jasmina, Radivojević, Nenad, Anđelković, Marija, Dikić, Nenad, "Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players" in Journal of Sports Medicine and Physical Fitness, 52, no. 4 (2012):382-392,
https://hdl.handle.net/21.15107/rcub_farfar_1654 .