TY  - JOUR
AU  - Ivanović, Nevena
AU  - Ilić, Tijana
AU  - Zrnić-Ćirić, Milica
AU  - Todorović, Vanja
AU  - Đuričić, Ivana
AU  - Dabetić, Nevena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4979
AB  - The disposal of waste generated in the agri-food industry is one of the greatest challenges
in achieving sustainable development. Although agri-food residues are a potential source of
bioactive compounds with proven health benefits, they are largely unused and disposed of as
organic waste. The recovery of bioactive compounds from agri-food waste to obtain products
with high biological value, such as functional foods and nutraceuticals, is an idea that stems from
the concept of bioeconomy and combines environmental issues with economically viable
production. Some of the main agri-food wastes in Serbia that have the potential to be recycled
into value-added products are apple, plum, grape, tomato, and beet pomace, and oilseed cakes.
Bioactive compounds isolated from these wastes include polyphenols, fibers, essential fatty acids,
minerals, various volatiles and pigments. This article focuses on the most common food wastes
and the potential reuse of these undervalued material to produce value-added products such as
functional foods, nutraceuticals or food additives.
AB  - Odlaganje otpada koji nastaje u prehrambenoj industriji jedan je od najvećih izazova u
postizanju održivog razvoja. Iako su nusproizvodi koji nastaju u prehrambenoj industriji
potencijalni izvor bioaktivnih jedinjenja sa dokazanim pozitivnim zdravstvenim efektima, oni se
uglavnom odlažu kao organski otpad. Iskorišćenje bioaktivnih jedinjenja iz ovih nusproizvoda u
cilju dobijanja proizvoda sa dodatom nutritivnom i biološkom vrednošću, kao što su funkcionalna
hrana i nutraceutici, ideja je koja proizilazi iz koncepta bioekonomije i kombinuje ekološki aspekt
sa ekonomski održivom proizvodnjom. Neki od glavnih nusproizvoda koji se generišu u Srbiji sa
potencijalom da se iskoriste u proizvodnji proizvoda sa dodatom vrednošću su trop jabuke, trop
šljive, komina grožđa, trop paradajza, uljane pogače i dr. Bioaktivna jedinjenja izolovana iz ovih
otpada uključuju polifenole, peptide, vlakna, esencijalne masne kiseline, minerale, različite
isparljive materije i pigmente. Ovaj članak se fokusira na najčešće otpade prehrambene industrije
i potencijalnu ponovnu upotrebu ovog još uvek neiskorišćenog otpadnog materijala za
proizvodnju proizvoda sa dodatom vrednošću kao što su funkcionalna hrana, nutraceutici ili
aditivi.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
T2  - Arhiv za farmaciju
T1  - Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals
T1  - Nusproizvodi agro-industrije kao izvor održivih sastojaka za proizvodnju funkcionalne hrane i nutraceutika
VL  - 73
IS  - 3
SP  - 190
EP  - 204
DO  - 10.5937/arhfarm73-44481
ER  - 

@article{
author = "Ivanović, Nevena and Ilić, Tijana and Zrnić-Ćirić, Milica and Todorović, Vanja and Đuričić, Ivana and Dabetić, Nevena",
year = "2023",
abstract = "The disposal of waste generated in the agri-food industry is one of the greatest challenges
in achieving sustainable development. Although agri-food residues are a potential source of
bioactive compounds with proven health benefits, they are largely unused and disposed of as
organic waste. The recovery of bioactive compounds from agri-food waste to obtain products
with high biological value, such as functional foods and nutraceuticals, is an idea that stems from
the concept of bioeconomy and combines environmental issues with economically viable
production. Some of the main agri-food wastes in Serbia that have the potential to be recycled
into value-added products are apple, plum, grape, tomato, and beet pomace, and oilseed cakes.
Bioactive compounds isolated from these wastes include polyphenols, fibers, essential fatty acids,
minerals, various volatiles and pigments. This article focuses on the most common food wastes
and the potential reuse of these undervalued material to produce value-added products such as
functional foods, nutraceuticals or food additives., Odlaganje otpada koji nastaje u prehrambenoj industriji jedan je od najvećih izazova u
postizanju održivog razvoja. Iako su nusproizvodi koji nastaju u prehrambenoj industriji
potencijalni izvor bioaktivnih jedinjenja sa dokazanim pozitivnim zdravstvenim efektima, oni se
uglavnom odlažu kao organski otpad. Iskorišćenje bioaktivnih jedinjenja iz ovih nusproizvoda u
cilju dobijanja proizvoda sa dodatom nutritivnom i biološkom vrednošću, kao što su funkcionalna
hrana i nutraceutici, ideja je koja proizilazi iz koncepta bioekonomije i kombinuje ekološki aspekt
sa ekonomski održivom proizvodnjom. Neki od glavnih nusproizvoda koji se generišu u Srbiji sa
potencijalom da se iskoriste u proizvodnji proizvoda sa dodatom vrednošću su trop jabuke, trop
šljive, komina grožđa, trop paradajza, uljane pogače i dr. Bioaktivna jedinjenja izolovana iz ovih
otpada uključuju polifenole, peptide, vlakna, esencijalne masne kiseline, minerale, različite
isparljive materije i pigmente. Ovaj članak se fokusira na najčešće otpade prehrambene industrije
i potencijalnu ponovnu upotrebu ovog još uvek neiskorišćenog otpadnog materijala za
proizvodnju proizvoda sa dodatom vrednošću kao što su funkcionalna hrana, nutraceutici ili
aditivi.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals, Nusproizvodi agro-industrije kao izvor održivih sastojaka za proizvodnju funkcionalne hrane i nutraceutika",
volume = "73",
number = "3",
pages = "190-204",
doi = "10.5937/arhfarm73-44481"
}

Ivanović, N., Ilić, T., Zrnić-Ćirić, M., Todorović, V., Đuričić, I.,& Dabetić, N.. (2023). Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 73(3), 190-204.
https://doi.org/10.5937/arhfarm73-44481

Ivanović N, Ilić T, Zrnić-Ćirić M, Todorović V, Đuričić I, Dabetić N. Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals. in Arhiv za farmaciju. 2023;73(3):190-204.
doi:10.5937/arhfarm73-44481 .

Ivanović, Nevena, Ilić, Tijana, Zrnić-Ćirić, Milica, Todorović, Vanja, Đuričić, Ivana, Dabetić, Nevena, "Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals" in Arhiv za farmaciju, 73, no. 3 (2023):190-204,
https://doi.org/10.5937/arhfarm73-44481 . .

TY  - JOUR
AU  - Zrnić-Ćirić, Milica
AU  - Kotur-Stevuljević, Jelena
AU  - Stanković, Ivan
AU  - Đorđević, Brižita
AU  - Baralić, Ivana
AU  - Ostojić, Miodrag
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4398
AB  - Background: The uneven lipid-lowering statin effects and
statin intolerance raise interest regarding the involvement
of coadministration of statins and dietary supplements.
This study aimed to evaluate the effects of octacosanol
supplementation on markers of redox status in cardiovascular patients on chronic atorvastatin therapy.
Methods: A double-blind, randomized, placebo-controlled,
single-centre study was conducted. Redox status home-
ostasis parameters  i.e., advanced oxidation protein products (AOPP), pro-oxidant-antioxidant balance (PAB), total
oxidant status (TOS), total antioxidant status (TAS), superoxide dismutase activity (SOD), total protein sulfhydryl (SH-
groups), and paraoxonase 1 (PON1) activity  were
assessed in 81 patients. According to favorable changes in
lipid profile, patients were classified into two groups:
responders (n = 35) and non-responders (n = 46), and
followed for 13 weeks. A principal component analysis
(PCA) was applied to explore the effect of octacosanol supplementation and the relationship between investigated
parameters as predictors of responders’ and non-responders’ status.
Results: Significant decrease in Oxy-score value was found
at the endpoint compared to baseline in responders’ group (21.0 (13.4–25.5) versus 15.1 (12.4–18.0); P < 0.01).
PCA analysis extracted 4 significant factors in the both
groups, whereas extracted factors containing »octacosanol
status« variable explained 14.7% and 11.5% of the variance
in responders’ and non-responders’ subgroups, respectively.
Conclusions: Octacosanol supplementation leads to an
improvement of lipid profile and markers of redox status in
responders’ group. New studies are needed to validate our
results in order to find the best approach for personalized
supplementation as a useful adjunct to standard statin
therapy.
AB  - Uvod: Neujednačeni hipolipemijski efekti primene statina kao i intolerancija na statine dovode do porasta inte resovanja u vezi sa zajedničkom primenom statina i dijetetskih suplemenata. Ova studija je imala za cilj da proceni efekte suplementacije oktakozanolom na markere redoks statusa kod kardiovaskularnih pacijenata na hroničnoj terapiji atorvastatinom. Metode: Sprovedena je dvostruko slepa, randomizovana, placebo kontrolisana studija. U serumu 81 pacijenta određivani su parametri redoks statusa [produkti uznapredovale oksidacije proteina (AOPP), prooksidativno-antioksidativni balans (PAB), totalni oksidativni status (TOS), totalni antioksidativni status (TAS), aktivnost superoksid dismutaze (SOD), sulfihidrilne grupe (SH-grupe) i aktivnost paraoksonaze 1 (PON1)]. U odnosu na povoljne promene lipidnog profila, pacijenti su klasifikovani u dve grupe: responderi (n = 35) i neresponderi (n = 46), i praćeni su 13 nedelja. Rezultati: Značajno smanjenje vrednosti oksi-skora primećeno je kod respondera na kraju studije u poređenju sa vrednostima na početku studije (21,0 (1 3,4 -25,5) vs. 15,1 (12,4 -18,0); P < 0,01). Principal component analiza (PCA) je primenjena da bi se procenio efekat suplementacije oktakozanolom kao i odnos između ispitivanih parametara kao prediktora odgovara u obe grupe. PCA analiza je izdvojila po 4 značajna faktora u obe grupe, pri čemu faktori koji sadrže varijablu "status oktakozanola" objašnjavaju 14,7% i 11,5% ukupne varijacije kod respondera i nerespondera, redom. Zaključak: Suplementacija oktakozanolom dovodi do poboljšanja lipidnog profila i markera redoks statusa u grupi respondera. Buduće studije su potrebne za potvrdu dobijenih rezultata a u cilju pronalaženja optimalnog pristupa za personalizovanu suplementaciju uz standardnu terapiju statinima.
PB  - Beograd : Društvo medicinskih biohemičara Srbije
T2  - Journal of Medical Biochemistry
T1  - Association of octacosanol supplementation with redox status in patients on chronic statin therapy
T1  - Povezanost suplementacije oktakozanolom i parametara redoks statusa kod pacijenata na hroničnoj terapiji atorvastatinom
VL  - 42
IS  - 1
SP  - 47
EP  - 57
DO  - 10.5937/jomb0-38224
ER  - 

@article{
author = "Zrnić-Ćirić, Milica and Kotur-Stevuljević, Jelena and Stanković, Ivan and Đorđević, Brižita and Baralić, Ivana and Ostojić, Miodrag",
year = "2023",
abstract = "Background: The uneven lipid-lowering statin effects and
statin intolerance raise interest regarding the involvement
of coadministration of statins and dietary supplements.
This study aimed to evaluate the effects of octacosanol
supplementation on markers of redox status in cardiovascular patients on chronic atorvastatin therapy.
Methods: A double-blind, randomized, placebo-controlled,
single-centre study was conducted. Redox status home-
ostasis parameters  i.e., advanced oxidation protein products (AOPP), pro-oxidant-antioxidant balance (PAB), total
oxidant status (TOS), total antioxidant status (TAS), superoxide dismutase activity (SOD), total protein sulfhydryl (SH-
groups), and paraoxonase 1 (PON1) activity  were
assessed in 81 patients. According to favorable changes in
lipid profile, patients were classified into two groups:
responders (n = 35) and non-responders (n = 46), and
followed for 13 weeks. A principal component analysis
(PCA) was applied to explore the effect of octacosanol supplementation and the relationship between investigated
parameters as predictors of responders’ and non-responders’ status.
Results: Significant decrease in Oxy-score value was found
at the endpoint compared to baseline in responders’ group (21.0 (13.4–25.5) versus 15.1 (12.4–18.0); P < 0.01).
PCA analysis extracted 4 significant factors in the both
groups, whereas extracted factors containing »octacosanol
status« variable explained 14.7% and 11.5% of the variance
in responders’ and non-responders’ subgroups, respectively.
Conclusions: Octacosanol supplementation leads to an
improvement of lipid profile and markers of redox status in
responders’ group. New studies are needed to validate our
results in order to find the best approach for personalized
supplementation as a useful adjunct to standard statin
therapy., Uvod: Neujednačeni hipolipemijski efekti primene statina kao i intolerancija na statine dovode do porasta inte resovanja u vezi sa zajedničkom primenom statina i dijetetskih suplemenata. Ova studija je imala za cilj da proceni efekte suplementacije oktakozanolom na markere redoks statusa kod kardiovaskularnih pacijenata na hroničnoj terapiji atorvastatinom. Metode: Sprovedena je dvostruko slepa, randomizovana, placebo kontrolisana studija. U serumu 81 pacijenta određivani su parametri redoks statusa [produkti uznapredovale oksidacije proteina (AOPP), prooksidativno-antioksidativni balans (PAB), totalni oksidativni status (TOS), totalni antioksidativni status (TAS), aktivnost superoksid dismutaze (SOD), sulfihidrilne grupe (SH-grupe) i aktivnost paraoksonaze 1 (PON1)]. U odnosu na povoljne promene lipidnog profila, pacijenti su klasifikovani u dve grupe: responderi (n = 35) i neresponderi (n = 46), i praćeni su 13 nedelja. Rezultati: Značajno smanjenje vrednosti oksi-skora primećeno je kod respondera na kraju studije u poređenju sa vrednostima na početku studije (21,0 (1 3,4 -25,5) vs. 15,1 (12,4 -18,0); P < 0,01). Principal component analiza (PCA) je primenjena da bi se procenio efekat suplementacije oktakozanolom kao i odnos između ispitivanih parametara kao prediktora odgovara u obe grupe. PCA analiza je izdvojila po 4 značajna faktora u obe grupe, pri čemu faktori koji sadrže varijablu "status oktakozanola" objašnjavaju 14,7% i 11,5% ukupne varijacije kod respondera i nerespondera, redom. Zaključak: Suplementacija oktakozanolom dovodi do poboljšanja lipidnog profila i markera redoks statusa u grupi respondera. Buduće studije su potrebne za potvrdu dobijenih rezultata a u cilju pronalaženja optimalnog pristupa za personalizovanu suplementaciju uz standardnu terapiju statinima.",
publisher = "Beograd : Društvo medicinskih biohemičara Srbije",
journal = "Journal of Medical Biochemistry",
title = "Association of octacosanol supplementation with redox status in patients on chronic statin therapy, Povezanost suplementacije oktakozanolom i parametara redoks statusa kod pacijenata na hroničnoj terapiji atorvastatinom",
volume = "42",
number = "1",
pages = "47-57",
doi = "10.5937/jomb0-38224"
}

Zrnić-Ćirić, M., Kotur-Stevuljević, J., Stanković, I., Đorđević, B., Baralić, I.,& Ostojić, M.. (2023). Association of octacosanol supplementation with redox status in patients on chronic statin therapy. in Journal of Medical Biochemistry
Beograd : Društvo medicinskih biohemičara Srbije., 42(1), 47-57.
https://doi.org/10.5937/jomb0-38224

Zrnić-Ćirić M, Kotur-Stevuljević J, Stanković I, Đorđević B, Baralić I, Ostojić M. Association of octacosanol supplementation with redox status in patients on chronic statin therapy. in Journal of Medical Biochemistry. 2023;42(1):47-57.
doi:10.5937/jomb0-38224 .

Zrnić-Ćirić, Milica, Kotur-Stevuljević, Jelena, Stanković, Ivan, Đorđević, Brižita, Baralić, Ivana, Ostojić, Miodrag, "Association of octacosanol supplementation with redox status in patients on chronic statin therapy" in Journal of Medical Biochemistry, 42, no. 1 (2023):47-57,
https://doi.org/10.5937/jomb0-38224 . .

TY  - CONF
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Zrnić-Ćirić, Milica
AU  - Đuričić, Ivana
AU  - Šobajić, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4499
AB  - Wine industry generates enormous quantities of solid organic waste consisted of
stems, skins and seeds. Grape seeds are considered the most valuable part of a pomace, since
it is rich in oil and containing numerous bioactive compounds. Grape seed oil (GSO)
composition depends mainly on grape variety, but also on environmental factors and
maturation degree. The aim of this study was to investigate the diversity of chemical
composition among seed oils obtained from different grape varieties. Eight varieties were
collected from the same wine region and at the same maturity phase. Investigation of fatty
acid composition was done using GC/FID, while HPLC/FD was employed for vitamin E
analyses. Linoleic acid was the most abundant in all samples, followed by oleic acid.
Saturated fatty acids, such as palmitic and stearic acid, were also present (up to 20 % of the
total fatty acid methyl esters). Vitamin E concentrations were significantly affected by grape
variety (p<0.01). α-tocopherol was found in high concentration in all samples. GSO from
Shiraz variety had about 25 mg α-tocopherol per kg of oil, while Gamay GSO contained more
than six times less amounts of this vitamin E isoform. Sum of β and γ tocopherol also varied
considerable, although Shiraz again stood out with the highest content. Finally, δ tocopherol
was found in four varieties, in minor quantities. Generally, considering variety diversification
on vitamin E composition of GSO, investigations that will include as much varieties as
possible, are needed to single out ones with the highest bio-oil potential.
AB  - Industrija vina ostavlja za sobom ogromne količine čvrstog organskog otpada koji se
sastoji od peteljki, pokožice i semenki grožđa. Semenke se smatraju najvrednijim delom
komine, jer su bogate uljem i sadrže brojna bioaktivna jedinjenja. Sastav ulja iz semenki
grožđa zavisi pre svega od sorte vinove loze, ali i od faktora sredine i stepena zrelosti ploda.
Cilj ovog rada bilo je ispitivanje raznolikosti hemijskog sastava ulja dobijenog iz semenki
različitih sorti grožđa. U tu svrhu, prikupljeno je osam sorti u istoj fazi zrelosti i iz istog
vinskog regiona. Ispitivanje sastava masnih kiselina vršeno je korišćenjem GC/FID, dok je
HPLC/FD korišćen za analizu koncentracije vitamina E. Linolna kiselina je bila
najzastupljenija u svim uzorcima, zatim oleinska kiselina. Zasićene masne kiseline, kao što su
palmitinska i stearinska kiselina, takođe su bile prisutne (do 20 % od ukupnih metil estara
masnih kiselina). Sorta vinove loze je značajno uticala na sadržaj vitamina E (p<0,01). α-
tokoferol je pronađen u visokim koncentracijama u svim uzorcima. Ulje iz semenki sorte
Širaz sadržalo je oko 25 miligrama α-tokoferola po kilogramu, dok je u ulju sorte Game
kvantifikovana šest puta manja koncentracija ove izoforme vitamina E. Zbir β i γ tokoferola
takođe je značajno varirao, iako se Širaz ponovo istakao sa najvećim sadržajem. δ tokoferol je
pronađen u ulju četiri sorte, u manjim količinama. Generalno, s obzirom na raznovrsnost
sastava vitamina E u ulju iz semenki grožđa, potrebna su opsežnija istraživanja koja će
obuhvatiti veći broj sorti vinove loze kako bi se izdvojile one sa najvećim potencijalom bio-
ulja.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Diversity of chemical composition among seed oils obtained from different grape varieties
T1  - Raznolikost hemijskog sastava ulja dobijenog iz semenki različitih sorti grožđa
VL  - 72
IS  - 4 suplement
SP  - S217
EP  - S218
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4499
ER  - 

@conference{
author = "Dabetić, Nevena and Todorović, Vanja and Zrnić-Ćirić, Milica and Đuričić, Ivana and Šobajić, Slađana",
year = "2022",
abstract = "Wine industry generates enormous quantities of solid organic waste consisted of
stems, skins and seeds. Grape seeds are considered the most valuable part of a pomace, since
it is rich in oil and containing numerous bioactive compounds. Grape seed oil (GSO)
composition depends mainly on grape variety, but also on environmental factors and
maturation degree. The aim of this study was to investigate the diversity of chemical
composition among seed oils obtained from different grape varieties. Eight varieties were
collected from the same wine region and at the same maturity phase. Investigation of fatty
acid composition was done using GC/FID, while HPLC/FD was employed for vitamin E
analyses. Linoleic acid was the most abundant in all samples, followed by oleic acid.
Saturated fatty acids, such as palmitic and stearic acid, were also present (up to 20 % of the
total fatty acid methyl esters). Vitamin E concentrations were significantly affected by grape
variety (p<0.01). α-tocopherol was found in high concentration in all samples. GSO from
Shiraz variety had about 25 mg α-tocopherol per kg of oil, while Gamay GSO contained more
than six times less amounts of this vitamin E isoform. Sum of β and γ tocopherol also varied
considerable, although Shiraz again stood out with the highest content. Finally, δ tocopherol
was found in four varieties, in minor quantities. Generally, considering variety diversification
on vitamin E composition of GSO, investigations that will include as much varieties as
possible, are needed to single out ones with the highest bio-oil potential., Industrija vina ostavlja za sobom ogromne količine čvrstog organskog otpada koji se
sastoji od peteljki, pokožice i semenki grožđa. Semenke se smatraju najvrednijim delom
komine, jer su bogate uljem i sadrže brojna bioaktivna jedinjenja. Sastav ulja iz semenki
grožđa zavisi pre svega od sorte vinove loze, ali i od faktora sredine i stepena zrelosti ploda.
Cilj ovog rada bilo je ispitivanje raznolikosti hemijskog sastava ulja dobijenog iz semenki
različitih sorti grožđa. U tu svrhu, prikupljeno je osam sorti u istoj fazi zrelosti i iz istog
vinskog regiona. Ispitivanje sastava masnih kiselina vršeno je korišćenjem GC/FID, dok je
HPLC/FD korišćen za analizu koncentracije vitamina E. Linolna kiselina je bila
najzastupljenija u svim uzorcima, zatim oleinska kiselina. Zasićene masne kiseline, kao što su
palmitinska i stearinska kiselina, takođe su bile prisutne (do 20 % od ukupnih metil estara
masnih kiselina). Sorta vinove loze je značajno uticala na sadržaj vitamina E (p<0,01). α-
tokoferol je pronađen u visokim koncentracijama u svim uzorcima. Ulje iz semenki sorte
Širaz sadržalo je oko 25 miligrama α-tokoferola po kilogramu, dok je u ulju sorte Game
kvantifikovana šest puta manja koncentracija ove izoforme vitamina E. Zbir β i γ tokoferola
takođe je značajno varirao, iako se Širaz ponovo istakao sa najvećim sadržajem. δ tokoferol je
pronađen u ulju četiri sorte, u manjim količinama. Generalno, s obzirom na raznovrsnost
sastava vitamina E u ulju iz semenki grožđa, potrebna su opsežnija istraživanja koja će
obuhvatiti veći broj sorti vinove loze kako bi se izdvojile one sa najvećim potencijalom bio-
ulja.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Diversity of chemical composition among seed oils obtained from different grape varieties, Raznolikost hemijskog sastava ulja dobijenog iz semenki različitih sorti grožđa",
volume = "72",
number = "4 suplement",
pages = "S217-S218",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4499"
}

Dabetić, N., Todorović, V., Zrnić-Ćirić, M., Đuričić, I.,& Šobajić, S.. (2022). Diversity of chemical composition among seed oils obtained from different grape varieties. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S217-S218.
https://hdl.handle.net/21.15107/rcub_farfar_4499

Dabetić N, Todorović V, Zrnić-Ćirić M, Đuričić I, Šobajić S. Diversity of chemical composition among seed oils obtained from different grape varieties. in Arhiv za farmaciju. 2022;72(4 suplement):S217-S218.
https://hdl.handle.net/21.15107/rcub_farfar_4499 .

Dabetić, Nevena, Todorović, Vanja, Zrnić-Ćirić, Milica, Đuričić, Ivana, Šobajić, Slađana, "Diversity of chemical composition among seed oils obtained from different grape varieties" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S217-S218,
https://hdl.handle.net/21.15107/rcub_farfar_4499 .

TY  - JOUR
AU  - Đuričić, Ivana
AU  - Todorović, Vanja
AU  - Dabetić, Nevena
AU  - Zrnić-Ćirić, Milica
AU  - Ivanović, Nevena
AU  - Vidović, Bojana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4404
AB  - Besides iodine deficiency, autoimmune Hashimoto thyroiditis is the leading cause of
hypothyroidism globally, characterized by the increased titer of thyroid autoantibodies and
destruction of thyroid cells. Graves' disease is the most common etiology of hyperthyroidism
worldwide. Patients with thyroid dysfunction often require dietary modifications. Popular
interventions include supplementation with certain vitamins and minerals, as well as trace
elements such as iodine and selenium. The intake of food containing goitrogens should be limited.
Goitrogens are substances of plant origin that interfere with the production of thyroid hormones,
increasing the risk for goiter and hypothyroidism. The primary dietary sources of goitrogens are
cruciferous vegetables, soy products, starchy plants, and some fruits. Beyond essential nutrients,
there has been an increasing interest in using specific nutraceuticals, including myoinositol, L-
carnitine, melatonin, and resveratrol, as potential preventive and therapeutic agents in thyroid
diseases. Even though current evidence promotes some beneficial outcomes of these
nutraceuticals, further investigations are needed to clarify dose-dependent effects, duration of
supplementation, combination in different clinical settings, and the exact mechanism of their
action in thyroid disorders.
AB  - Pored nedostatka joda, najčešća etiologija hipotireoze u razvijenim zemljama je Hašimoto tireoiditis, koji karakteriše povišen nivo serum autoantitela i limfocitna infiltracija štitaste žlezde. Grejvsova bolest je vodeći uzrok hipertireoza na globalnom nivou. Pacijenti sa oboljenjem štitaste žlezde često zahtevaju modifikaciju dijetarnog režima. Popularne intervencije uključuju suplementaciju određenim vitaminima, mineralima i mikroelementima kao što su jod i selen. Preporučuje se ograničen unos namirnica koje sadrže goitrogene supstance jer ometaju normalnu sintezu tiroidnih hormona, povećavajući rizik za nastanak strume i hipotireoze. Primarni izvori goitrogena u ishrani su kruciferno povrće, proizvodi od soje, skrobne biljke i pojedine vrste voća. Osim esencijalnih nutrijenata, postoji sve veće interesovanje za primenu specifičnih nutraceutika u prevenciji i koterapiji bolesti štitaste žlezde, kao što su mioinozitol, L-karnitin, melatonin i rezveratrol. Trenutni dokazi ukazuju na moguće promotivne efekte ovih jedinjenja u oboljenjima štitaste žlezde. Potrebna su dalja ispitivanja koja bi pratila uticaj doze i dužine suplementacije nutraceutika i potvrdila tačne mehanizme njihovog delovanja u poremećajima funkcije štitaste žlezde.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Dietary factors and thyroid dysfunction
T1  - Dijetarni faktori i tiroidna disfunkcija
VL  - 72
IS  - 5
SP  - 455
EP  - 467
DO  - 10.5937/arhfarm72-39624
ER  - 

@article{
author = "Đuričić, Ivana and Todorović, Vanja and Dabetić, Nevena and Zrnić-Ćirić, Milica and Ivanović, Nevena and Vidović, Bojana",
year = "2022",
abstract = "Besides iodine deficiency, autoimmune Hashimoto thyroiditis is the leading cause of
hypothyroidism globally, characterized by the increased titer of thyroid autoantibodies and
destruction of thyroid cells. Graves' disease is the most common etiology of hyperthyroidism
worldwide. Patients with thyroid dysfunction often require dietary modifications. Popular
interventions include supplementation with certain vitamins and minerals, as well as trace
elements such as iodine and selenium. The intake of food containing goitrogens should be limited.
Goitrogens are substances of plant origin that interfere with the production of thyroid hormones,
increasing the risk for goiter and hypothyroidism. The primary dietary sources of goitrogens are
cruciferous vegetables, soy products, starchy plants, and some fruits. Beyond essential nutrients,
there has been an increasing interest in using specific nutraceuticals, including myoinositol, L-
carnitine, melatonin, and resveratrol, as potential preventive and therapeutic agents in thyroid
diseases. Even though current evidence promotes some beneficial outcomes of these
nutraceuticals, further investigations are needed to clarify dose-dependent effects, duration of
supplementation, combination in different clinical settings, and the exact mechanism of their
action in thyroid disorders., Pored nedostatka joda, najčešća etiologija hipotireoze u razvijenim zemljama je Hašimoto tireoiditis, koji karakteriše povišen nivo serum autoantitela i limfocitna infiltracija štitaste žlezde. Grejvsova bolest je vodeći uzrok hipertireoza na globalnom nivou. Pacijenti sa oboljenjem štitaste žlezde često zahtevaju modifikaciju dijetarnog režima. Popularne intervencije uključuju suplementaciju određenim vitaminima, mineralima i mikroelementima kao što su jod i selen. Preporučuje se ograničen unos namirnica koje sadrže goitrogene supstance jer ometaju normalnu sintezu tiroidnih hormona, povećavajući rizik za nastanak strume i hipotireoze. Primarni izvori goitrogena u ishrani su kruciferno povrće, proizvodi od soje, skrobne biljke i pojedine vrste voća. Osim esencijalnih nutrijenata, postoji sve veće interesovanje za primenu specifičnih nutraceutika u prevenciji i koterapiji bolesti štitaste žlezde, kao što su mioinozitol, L-karnitin, melatonin i rezveratrol. Trenutni dokazi ukazuju na moguće promotivne efekte ovih jedinjenja u oboljenjima štitaste žlezde. Potrebna su dalja ispitivanja koja bi pratila uticaj doze i dužine suplementacije nutraceutika i potvrdila tačne mehanizme njihovog delovanja u poremećajima funkcije štitaste žlezde.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Dietary factors and thyroid dysfunction, Dijetarni faktori i tiroidna disfunkcija",
volume = "72",
number = "5",
pages = "455-467",
doi = "10.5937/arhfarm72-39624"
}

Đuričić, I., Todorović, V., Dabetić, N., Zrnić-Ćirić, M., Ivanović, N.,& Vidović, B.. (2022). Dietary factors and thyroid dysfunction. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 72(5), 455-467.
https://doi.org/10.5937/arhfarm72-39624

Đuričić I, Todorović V, Dabetić N, Zrnić-Ćirić M, Ivanović N, Vidović B. Dietary factors and thyroid dysfunction. in Arhiv za farmaciju. 2022;72(5):455-467.
doi:10.5937/arhfarm72-39624 .

Đuričić, Ivana, Todorović, Vanja, Dabetić, Nevena, Zrnić-Ćirić, Milica, Ivanović, Nevena, Vidović, Bojana, "Dietary factors and thyroid dysfunction" in Arhiv za farmaciju, 72, no. 5 (2022):455-467,
https://doi.org/10.5937/arhfarm72-39624 . .

TY  - JOUR
AU  - Đuričić, Ivana
AU  - Zrnić-Ćirić, Milica
AU  - Vidović, Bojana
AU  - Todorović, Vanja
AU  - Dabetić, Nevena
AU  - Ivanović, Nevena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5375
AB  - The immune system defends the host from many pathogen-
ic microorganisms such as viruses, bacteria, parasites and
fungi, including a large number of specific cell types, inter-
related molecules, and biological responses. Due to infec-
tions, heightened immune system activity is accompanied
by expanded metabolic activities, requiring appropriate
energy supply, precursors for biosynthesis and regulatory
molecules. Numerous vitamins and minerals play a crucial
role in supporting body’s immunity and fighting against
viral infections. Other bioactive compounds like omega-3
fatty acids, probiotics and antioxidants (alpha-lipoic acid,
quercetin) are also important in the immune response. CO-
VID-19 may develop mild symptoms to severe damage of
the respiratory epithelium followed by a cytokine storm.
Many studies show that vitamin C, vitamin D, zinc and selenium are critical in defending against SARS-CoV-2 infection.
Intestinal dysbiosis is a feature of many infectious diseases, including COVID-19, so dietary approaches to establishing a
healthy microbiota are essential for improving immune function. This paper reviews the data on the roles and potential
effectiveness of selected nutraceuticals in the prevention and treatment of COVID-19.
AB  - Imunski sistem štiti organizam od brojnih patogena (bakterija, virusa, gljivica, parazita) uključujući veliki broj specijalizovanih tipova ćelija, komunikacionih molekula i
funkcionalnih odgovora. Pojačana aktivnost imunskog si
stema usled infekcija praćena je povećanim metaboličkim
aktivnostima, što zahteva izvore energije, supstrate za biosintezu i regulatorne molekule. Brojni vitamini i minerali
imaju ključnu ulogu u podršci imunskom sistemu i smanjenju rizika od infekcija. Ostale bioaktivne komponente kao omega-3 masne kiseline, probiotici i antioksidansi (alfa-lipoinska kiselina, kvercetin) takođe su od značaja u imunološkom
odgovoru. COVID-19 karakterišu kliničke slike od blagih simptoma do teške infekcije respiratornog epitela praćene citokinskom olujom. Pokazano je da starije osobe sa hroničnim bolestima imaju smanjenu aktivnost odbrambenog sistema
i neadekvatan nutritivni status, zbog čega postoji veći rizik za pojavu fatalnih ishoda. Ispitivanja ukazuju da su vitamin
C, vitamin D, cink i selen posebno važni u odbrani od infekcije SARS-CoV-2. Disbioza creva je karakteristika mnogih zaraznih bolesti uključujući COVID-19, zato su dijetetski pristupi za uspostavljanje zdrave mikrobiote važni u poboljšanju
imunoloških funkcija. U ovom radu prikazan je pregled literature o ulozi i potencijalnoj primeni odabranih nutraceutika u
prevenciji i tretmanu COVID-19.
PB  - Društvo za ishranu Srbije, Beograd
T2  - Hrana i ishrana
T1  - Nutraceuticals in prevention and management of COVID-19
T1  - Nutraceutici u prevenciji i tretmanu COVID-19
VL  - 62
IS  - 2
SP  - 7
EP  - 14
DO  - 10.5937/hraIsh2102007D
ER  - 

@article{
author = "Đuričić, Ivana and Zrnić-Ćirić, Milica and Vidović, Bojana and Todorović, Vanja and Dabetić, Nevena and Ivanović, Nevena",
year = "2021",
abstract = "The immune system defends the host from many pathogen-
ic microorganisms such as viruses, bacteria, parasites and
fungi, including a large number of specific cell types, inter-
related molecules, and biological responses. Due to infec-
tions, heightened immune system activity is accompanied
by expanded metabolic activities, requiring appropriate
energy supply, precursors for biosynthesis and regulatory
molecules. Numerous vitamins and minerals play a crucial
role in supporting body’s immunity and fighting against
viral infections. Other bioactive compounds like omega-3
fatty acids, probiotics and antioxidants (alpha-lipoic acid,
quercetin) are also important in the immune response. CO-
VID-19 may develop mild symptoms to severe damage of
the respiratory epithelium followed by a cytokine storm.
Many studies show that vitamin C, vitamin D, zinc and selenium are critical in defending against SARS-CoV-2 infection.
Intestinal dysbiosis is a feature of many infectious diseases, including COVID-19, so dietary approaches to establishing a
healthy microbiota are essential for improving immune function. This paper reviews the data on the roles and potential
effectiveness of selected nutraceuticals in the prevention and treatment of COVID-19., Imunski sistem štiti organizam od brojnih patogena (bakterija, virusa, gljivica, parazita) uključujući veliki broj specijalizovanih tipova ćelija, komunikacionih molekula i
funkcionalnih odgovora. Pojačana aktivnost imunskog si
stema usled infekcija praćena je povećanim metaboličkim
aktivnostima, što zahteva izvore energije, supstrate za biosintezu i regulatorne molekule. Brojni vitamini i minerali
imaju ključnu ulogu u podršci imunskom sistemu i smanjenju rizika od infekcija. Ostale bioaktivne komponente kao omega-3 masne kiseline, probiotici i antioksidansi (alfa-lipoinska kiselina, kvercetin) takođe su od značaja u imunološkom
odgovoru. COVID-19 karakterišu kliničke slike od blagih simptoma do teške infekcije respiratornog epitela praćene citokinskom olujom. Pokazano je da starije osobe sa hroničnim bolestima imaju smanjenu aktivnost odbrambenog sistema
i neadekvatan nutritivni status, zbog čega postoji veći rizik za pojavu fatalnih ishoda. Ispitivanja ukazuju da su vitamin
C, vitamin D, cink i selen posebno važni u odbrani od infekcije SARS-CoV-2. Disbioza creva je karakteristika mnogih zaraznih bolesti uključujući COVID-19, zato su dijetetski pristupi za uspostavljanje zdrave mikrobiote važni u poboljšanju
imunoloških funkcija. U ovom radu prikazan je pregled literature o ulozi i potencijalnoj primeni odabranih nutraceutika u
prevenciji i tretmanu COVID-19.",
publisher = "Društvo za ishranu Srbije, Beograd",
journal = "Hrana i ishrana",
title = "Nutraceuticals in prevention and management of COVID-19, Nutraceutici u prevenciji i tretmanu COVID-19",
volume = "62",
number = "2",
pages = "7-14",
doi = "10.5937/hraIsh2102007D"
}

Đuričić, I., Zrnić-Ćirić, M., Vidović, B., Todorović, V., Dabetić, N.,& Ivanović, N.. (2021). Nutraceuticals in prevention and management of COVID-19. in Hrana i ishrana
Društvo za ishranu Srbije, Beograd., 62(2), 7-14.
https://doi.org/10.5937/hraIsh2102007D

Đuričić I, Zrnić-Ćirić M, Vidović B, Todorović V, Dabetić N, Ivanović N. Nutraceuticals in prevention and management of COVID-19. in Hrana i ishrana. 2021;62(2):7-14.
doi:10.5937/hraIsh2102007D .

Đuričić, Ivana, Zrnić-Ćirić, Milica, Vidović, Bojana, Todorović, Vanja, Dabetić, Nevena, Ivanović, Nevena, "Nutraceuticals in prevention and management of COVID-19" in Hrana i ishrana, 62, no. 2 (2021):7-14,
https://doi.org/10.5937/hraIsh2102007D . .

TY  - JOUR
AU  - Zrnić-Ćirić, Milica
AU  - Ostojić, Miodrag
AU  - Baralić, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Đorđević, Brižita
AU  - Marković, Stana
AU  - Živković, Stefan
AU  - Stanković, Ivan
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3818
AB  - Dietary supplementation with sugar cane derivates may modulate low-density lipoproteincholesterol (LDL-C) and proprotein convertase subtilisin/kexin type 9 (PCSK9) levels. The purposeof this study was to determine if dietary supplement (DS), containing Octacosanol (20 mg) andvitamin K2 (45μg), could restore the disrupted physiologic relation between LDL-C and serumPCSK9. Double-blind, randomized, placebo-controlled, single-center study including 87 patients onchronic atorvastatin therapy was conducted. Eighty-seven patients were randomized to receive DS(n= 42) or placebo (n= 45), and followed for 13 weeks. Serum PCSK9 levels, lipid parameters andtheir relationship were the main efficacy endpoints. The absolute levels of PCSK9 and LDL-C werenot significantly different from baseline to 13 weeks. However, physiologic correlation between %change of PCSK9 and % change of LDL-C levels was normalized only in the group of patients treatedwith DS (r= 0.409,p= 0.012).  This study shows that DS can restore statin disrupted physiologicpositive correlation between PCSK9 and LDL-C. Elevated PCSK9 level is an independent risk factorso controlling its rise by statins may be important in prevention of cardiovascular events.
PB  - MDPI
T2  - Nutrients
T1  - Supplementation with Octacosanol Affects the Level of PCSK9 and Restore Its Physiologic Relation with LDL-C in Patients on Chronic Statin Therapy
VL  - 13
IS  - 3
DO  - 10.3390/nu13030903
ER  - 

@article{
author = "Zrnić-Ćirić, Milica and Ostojić, Miodrag and Baralić, Ivana and Kotur-Stevuljević, Jelena and Đorđević, Brižita and Marković, Stana and Živković, Stefan and Stanković, Ivan",
year = "2021",
abstract = "Dietary supplementation with sugar cane derivates may modulate low-density lipoproteincholesterol (LDL-C) and proprotein convertase subtilisin/kexin type 9 (PCSK9) levels. The purposeof this study was to determine if dietary supplement (DS), containing Octacosanol (20 mg) andvitamin K2 (45μg), could restore the disrupted physiologic relation between LDL-C and serumPCSK9. Double-blind, randomized, placebo-controlled, single-center study including 87 patients onchronic atorvastatin therapy was conducted. Eighty-seven patients were randomized to receive DS(n= 42) or placebo (n= 45), and followed for 13 weeks. Serum PCSK9 levels, lipid parameters andtheir relationship were the main efficacy endpoints. The absolute levels of PCSK9 and LDL-C werenot significantly different from baseline to 13 weeks. However, physiologic correlation between %change of PCSK9 and % change of LDL-C levels was normalized only in the group of patients treatedwith DS (r= 0.409,p= 0.012).  This study shows that DS can restore statin disrupted physiologicpositive correlation between PCSK9 and LDL-C. Elevated PCSK9 level is an independent risk factorso controlling its rise by statins may be important in prevention of cardiovascular events.",
publisher = "MDPI",
journal = "Nutrients",
title = "Supplementation with Octacosanol Affects the Level of PCSK9 and Restore Its Physiologic Relation with LDL-C in Patients on Chronic Statin Therapy",
volume = "13",
number = "3",
doi = "10.3390/nu13030903"
}

Zrnić-Ćirić, M., Ostojić, M., Baralić, I., Kotur-Stevuljević, J., Đorđević, B., Marković, S., Živković, S.,& Stanković, I.. (2021). Supplementation with Octacosanol Affects the Level of PCSK9 and Restore Its Physiologic Relation with LDL-C in Patients on Chronic Statin Therapy. in Nutrients
MDPI., 13(3).
https://doi.org/10.3390/nu13030903

Zrnić-Ćirić M, Ostojić M, Baralić I, Kotur-Stevuljević J, Đorđević B, Marković S, Živković S, Stanković I. Supplementation with Octacosanol Affects the Level of PCSK9 and Restore Its Physiologic Relation with LDL-C in Patients on Chronic Statin Therapy. in Nutrients. 2021;13(3).
doi:10.3390/nu13030903 .

Zrnić-Ćirić, Milica, Ostojić, Miodrag, Baralić, Ivana, Kotur-Stevuljević, Jelena, Đorđević, Brižita, Marković, Stana, Živković, Stefan, Stanković, Ivan, "Supplementation with Octacosanol Affects the Level of PCSK9 and Restore Its Physiologic Relation with LDL-C in Patients on Chronic Statin Therapy" in Nutrients, 13, no. 3 (2021),
https://doi.org/10.3390/nu13030903 . .

TY  - JOUR
AU  - Stanković, Ivan
AU  - Zrnić-Ćirić, Milica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3807
AB  - Food additive is any substance not normally consumed as a food, the intentional addition of which to food for a technological purpose results in it or its by-products becoming a component of such foods. The use of each new additive is preceded by a risk analysis consisting of three interrelated components: risk assessment, risk management and risk communication. At the international level in the Codex Alimentarius system, risk assessment is performed by the Joint (FAO/WHO) Expert Committee on Food Additives (JECFA) and risk management by Codex Alimentarius Commission (CAC) that, based on the results of the risk assessment, prepares international  standards  and  recommendations  that  Member  States incorporate  into  national regulations. At the level of the European Union (EU), risk assessment is performed by the European  Food  Safety  Authority  (EFSA)  as  a  basis  for  risk  management  by  the  European Commission  (EC)  that  prepares  food  additive  legislation,  and  member  states  authorities responsible for official control of additives on the market. Risk communication takes place between all stakeholders including academia, food producers and consumers. The regulation on additives in the Republic of Serbia is fully harmonized with the EU legislation in this area.
AB  - Prehrambeni aditiv je svaka supstanca koja se normalno ne koristi kao sastojak hrane, a koja se iz tehnoloških razloga namerno dodaje hrani u toku proizvodnje, prerade, pripreme, obrade, pakovanja, transporta ili čuvanja, tako da direktno ili indirektno preko svojih međuproizvoda postaje sastojak hrane. Upotrebi svakog aditiva prethodi analiza rizika koja se sastoji od tri međusobno povezane komponente: procene rizika, upravljanja rizikom i komunikacije o riziku. Na međunarodnom nivou u sistemu Codex Alimentarius-a procenu rizika radi Zajednički (FAO/WHO) ekspertski komitet za prehrambene aditive (JECFA) koji priprema hemijske specifikacije, vrši procenu izloženosti i kvantitativnu procenu bezbednosti upotrebe aditiva u hrani, a upravljanje rizikom radi Komisija Codex Alimentarius (CAC) koja na bazi rezultata procene rizika priprema međunarodne standarde i preporuke za upotrebu aditiva koje zemlje članice ugrađuju u nacionalne propise. Na nivou Evropske Unije (EU) procenu rizika radi Evropsko telo za bezbednost hrane (EFSA), a upravljanje rizikom Evropska komisija (EC) koja donosi propise, kao i nadležna ministarstva zemalja članica koja sprovode službenu kontrolu. Komunikacija o riziku odvija se između svih zainteresovanih strana uključujući i akademske krugove, proizvođače i konzumente hrane. Regulativa o aditivima u Republici Srbiji harmonizovana je sa regulativom EU u ovoj oblasti.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - Food additives – risk analysis and legislation
T1  - Prehrambeni aditivi – analiza rizika i regulativa
VL  - 71
IS  - 1
SP  - 22
EP  - 34
DO  - 10.5937/arhfarm71-30117
ER  - 

@article{
author = "Stanković, Ivan and Zrnić-Ćirić, Milica",
year = "2021",
abstract = "Food additive is any substance not normally consumed as a food, the intentional addition of which to food for a technological purpose results in it or its by-products becoming a component of such foods. The use of each new additive is preceded by a risk analysis consisting of three interrelated components: risk assessment, risk management and risk communication. At the international level in the Codex Alimentarius system, risk assessment is performed by the Joint (FAO/WHO) Expert Committee on Food Additives (JECFA) and risk management by Codex Alimentarius Commission (CAC) that, based on the results of the risk assessment, prepares international  standards  and  recommendations  that  Member  States incorporate  into  national regulations. At the level of the European Union (EU), risk assessment is performed by the European  Food  Safety  Authority  (EFSA)  as  a  basis  for  risk  management  by  the  European Commission  (EC)  that  prepares  food  additive  legislation,  and  member  states  authorities responsible for official control of additives on the market. Risk communication takes place between all stakeholders including academia, food producers and consumers. The regulation on additives in the Republic of Serbia is fully harmonized with the EU legislation in this area., Prehrambeni aditiv je svaka supstanca koja se normalno ne koristi kao sastojak hrane, a koja se iz tehnoloških razloga namerno dodaje hrani u toku proizvodnje, prerade, pripreme, obrade, pakovanja, transporta ili čuvanja, tako da direktno ili indirektno preko svojih međuproizvoda postaje sastojak hrane. Upotrebi svakog aditiva prethodi analiza rizika koja se sastoji od tri međusobno povezane komponente: procene rizika, upravljanja rizikom i komunikacije o riziku. Na međunarodnom nivou u sistemu Codex Alimentarius-a procenu rizika radi Zajednički (FAO/WHO) ekspertski komitet za prehrambene aditive (JECFA) koji priprema hemijske specifikacije, vrši procenu izloženosti i kvantitativnu procenu bezbednosti upotrebe aditiva u hrani, a upravljanje rizikom radi Komisija Codex Alimentarius (CAC) koja na bazi rezultata procene rizika priprema međunarodne standarde i preporuke za upotrebu aditiva koje zemlje članice ugrađuju u nacionalne propise. Na nivou Evropske Unije (EU) procenu rizika radi Evropsko telo za bezbednost hrane (EFSA), a upravljanje rizikom Evropska komisija (EC) koja donosi propise, kao i nadležna ministarstva zemalja članica koja sprovode službenu kontrolu. Komunikacija o riziku odvija se između svih zainteresovanih strana uključujući i akademske krugove, proizvođače i konzumente hrane. Regulativa o aditivima u Republici Srbiji harmonizovana je sa regulativom EU u ovoj oblasti.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Food additives – risk analysis and legislation, Prehrambeni aditivi – analiza rizika i regulativa",
volume = "71",
number = "1",
pages = "22-34",
doi = "10.5937/arhfarm71-30117"
}

Stanković, I.,& Zrnić-Ćirić, M.. (2021). Food additives – risk analysis and legislation. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 71(1), 22-34.
https://doi.org/10.5937/arhfarm71-30117

Stanković I, Zrnić-Ćirić M. Food additives – risk analysis and legislation. in Arhiv za farmaciju. 2021;71(1):22-34.
doi:10.5937/arhfarm71-30117 .

Stanković, Ivan, Zrnić-Ćirić, Milica, "Food additives – risk analysis and legislation" in Arhiv za farmaciju, 71, no. 1 (2021):22-34,
https://doi.org/10.5937/arhfarm71-30117 . .

TY  - JOUR
AU  - Zrnić-Ćirić, Milica
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Đuriš, Jelena
AU  - Vidović, Bojana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3628
AB  - Due to the presence of numerous bioactive compounds, including polysaccharides and polyphenols, mushroom-based food supplements are claimed to have many beneficial health effects. Despite their popularity, concerns have been raised in recent years over the quality of mushroom products, particularly regarding their non-standardized chemical composition. In this study, the β-glucan and total phenolic contents, as well as the antioxidant potential of mushroom-derived supplements available on the Serbian market were analyzed. The obtained results, revealing considerable differences in β-glucan and total polyphenol contents among these products, reflect variations in mushroom species, forms and recommended dosing regimens. A correlation between the total phenolic content and antioxidant activity was observed. The presence of other active ingredients, such as vitamin C, has contributed to antioxidant variability among the analyzed products. The obtained results indicate the need for the standardization of mushroom-derived food supplements to ensure their claiming effects.
AB  - ANALYSIS AND ANTIOXIDANT ACTIVITIES OF MUSHROOM BASED-DIETARY SUPPLEMENTS 449
ИЗВОД АНАЛИЗА САДРЖАЈА

БЕТА-ГЛУКАНА И АНТИОКСИДАТИВНА АКТИВНОСТ У ДОДАЦИМА ИСХРАНИ НА БАЗИ ГЉИВА 
МИЛИЦА ЗРНИЋЋИРИЋ1, НЕВЕНА ДАБЕТИЋ1, ВАЊА ТОДОРОВИЋ1, ЈЕЛЕНА ЂУРИШ2 и БОЈАНА ВИДОВИЋ11 Универзитет у Београду, Фармацеутскифакултет, Катедра за Броматологију, Београд Универзитет у Београду, Фармацеутски факултет, Катедра за Фармацеутску технологију и козметологију, Београд. Због присуства бројних биоактивних састојака, укључујући полисахариде и поли-феноле, додаци исхрани на бази гљива имају бројне позитивне здравствене ефекте. Поред популарности, последњих година се велика пажња посвећује и квалитету производа од гљива, посебно у погледу њиховог не стандардизованог хемијског састава. У овом раду анализиранје садржајβ-глукана и укупних полифенола, као и антиоксидативни потенцијал додатака исхрани на бази гљива који су доступни на тржишту Србије. Добијени резултати су показали велике разлике у садржају β-глукана и укупних полифенола што се може објаснити различитим врстама гљива, облицима и режимима дозирања. Уочена је корелација између укупног садржаја полифенола и антиоксидативне активности. Присуство других биолошки активних састојака, као што је витамин Ц, допринело је варијабилности антиоксидантне активности између анализираних производа. Добијени резултати указују на потребу за стандардизацијом дoдатака исхрани на бази гљива, како би се осигурао њихов ефекат.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Beta-glucan content and antioxidant activities of mushroom-derived food supplements
VL  - 85
IS  - 4
SP  - 439
EP  - 451
DO  - 10.2298/JSC190701121Z
ER  - 

@article{
author = "Zrnić-Ćirić, Milica and Dabetić, Nevena and Todorović, Vanja and Đuriš, Jelena and Vidović, Bojana",
year = "2020",
abstract = "Due to the presence of numerous bioactive compounds, including polysaccharides and polyphenols, mushroom-based food supplements are claimed to have many beneficial health effects. Despite their popularity, concerns have been raised in recent years over the quality of mushroom products, particularly regarding their non-standardized chemical composition. In this study, the β-glucan and total phenolic contents, as well as the antioxidant potential of mushroom-derived supplements available on the Serbian market were analyzed. The obtained results, revealing considerable differences in β-glucan and total polyphenol contents among these products, reflect variations in mushroom species, forms and recommended dosing regimens. A correlation between the total phenolic content and antioxidant activity was observed. The presence of other active ingredients, such as vitamin C, has contributed to antioxidant variability among the analyzed products. The obtained results indicate the need for the standardization of mushroom-derived food supplements to ensure their claiming effects., ANALYSIS AND ANTIOXIDANT ACTIVITIES OF MUSHROOM BASED-DIETARY SUPPLEMENTS 449
ИЗВОД АНАЛИЗА САДРЖАЈА

БЕТА-ГЛУКАНА И АНТИОКСИДАТИВНА АКТИВНОСТ У ДОДАЦИМА ИСХРАНИ НА БАЗИ ГЉИВА 
МИЛИЦА ЗРНИЋЋИРИЋ1, НЕВЕНА ДАБЕТИЋ1, ВАЊА ТОДОРОВИЋ1, ЈЕЛЕНА ЂУРИШ2 и БОЈАНА ВИДОВИЋ11 Универзитет у Београду, Фармацеутскифакултет, Катедра за Броматологију, Београд Универзитет у Београду, Фармацеутски факултет, Катедра за Фармацеутску технологију и козметологију, Београд. Због присуства бројних биоактивних састојака, укључујући полисахариде и поли-феноле, додаци исхрани на бази гљива имају бројне позитивне здравствене ефекте. Поред популарности, последњих година се велика пажња посвећује и квалитету производа од гљива, посебно у погледу њиховог не стандардизованог хемијског састава. У овом раду анализиранје садржајβ-глукана и укупних полифенола, као и антиоксидативни потенцијал додатака исхрани на бази гљива који су доступни на тржишту Србије. Добијени резултати су показали велике разлике у садржају β-глукана и укупних полифенола што се може објаснити различитим врстама гљива, облицима и режимима дозирања. Уочена је корелација између укупног садржаја полифенола и антиоксидативне активности. Присуство других биолошки активних састојака, као што је витамин Ц, допринело је варијабилности антиоксидантне активности између анализираних производа. Добијени резултати указују на потребу за стандардизацијом дoдатака исхрани на бази гљива, како би се осигурао њихов ефекат.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Beta-glucan content and antioxidant activities of mushroom-derived food supplements",
volume = "85",
number = "4",
pages = "439-451",
doi = "10.2298/JSC190701121Z"
}

Zrnić-Ćirić, M., Dabetić, N., Todorović, V., Đuriš, J.,& Vidović, B.. (2020). Beta-glucan content and antioxidant activities of mushroom-derived food supplements. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 85(4), 439-451.
https://doi.org/10.2298/JSC190701121Z

Zrnić-Ćirić M, Dabetić N, Todorović V, Đuriš J, Vidović B. Beta-glucan content and antioxidant activities of mushroom-derived food supplements. in Journal of the Serbian Chemical Society. 2020;85(4):439-451.
doi:10.2298/JSC190701121Z .

Zrnić-Ćirić, Milica, Dabetić, Nevena, Todorović, Vanja, Đuriš, Jelena, Vidović, Bojana, "Beta-glucan content and antioxidant activities of mushroom-derived food supplements" in Journal of the Serbian Chemical Society, 85, no. 4 (2020):439-451,
https://doi.org/10.2298/JSC190701121Z . .

TY  - CONF
AU  - Zrnić-Ćirić, Milica
AU  - Kotur-Stevuljević, Jelena
AU  - Baralić, Ivana
AU  - Đorđević, Brižita
AU  - Stanković, Ivan
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5395
AB  - Statins reduce the risk of cardiovascular disease mainly due to cholesterol reduction, but also
pleiotropic effects are present. Co-administration of statins with bioactive molecules may
obtain a synergistic benefit. The aim of this randomized, placebo-controlled, double-blind
study was to investigate whether 13-week long supplementation of policosanol affected
antioxidant status and markers of oxidative stress in patients on atorvastatin therapy. Eighty-
seven patients aged 40–80 years on chronic (>4 months) atorvastatin therapy (20 mg) were
randomly allocated to policosanol (n=42) or placebo (n=45). At baseline, after 8 and 13 weeks,
markers of oxidative stress and antioxidant defence include total antioxidant status (TAS), total
oxidant status (TOS), advanced oxidation protein products (AOPP) and activity of superoxide
dismutase (SOD) were measured. Creatinine phosphokinase and hepatic enzymes were the
main safety endpoints. The mean age of the patients was 62.6 ± 0.8 years. Patients in
supplemented group had higher TAS and TOS levels 1640 (963–1752) vs 927 (481–1305),
[μmol/L], p < 0.001 and 18 (13––20) vs 6 (5–11), [μmol/L], p < 0.001], respectively, compared
to baseline. In placebo group, subjects had also higher TAS and TOS levels after 13-week
compared to baseline. SOD and AOPP were not influenced by the intervention. The
investigated supplement possessed a good safety profile. Combination of policosanol with
atorvastatin may be useful in an attempt to avoid potential adverse effects associated with
statins. 13-week supplementation was not sufficient to induce remarkably changes in SOD and
AOPP. TAS and TOS were increased in both groups.
PB  - University of Belgrade, Belgrade, Serbia
C3  - Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade
T1  - May thirteen weeks of octacosanol supplementation affect prooxidant-antioxidant balance in patients on atorvastatin therapy
SP  - 15
EP  - 15
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5395
ER  - 

@conference{
author = "Zrnić-Ćirić, Milica and Kotur-Stevuljević, Jelena and Baralić, Ivana and Đorđević, Brižita and Stanković, Ivan",
year = "2020",
abstract = "Statins reduce the risk of cardiovascular disease mainly due to cholesterol reduction, but also
pleiotropic effects are present. Co-administration of statins with bioactive molecules may
obtain a synergistic benefit. The aim of this randomized, placebo-controlled, double-blind
study was to investigate whether 13-week long supplementation of policosanol affected
antioxidant status and markers of oxidative stress in patients on atorvastatin therapy. Eighty-
seven patients aged 40–80 years on chronic (>4 months) atorvastatin therapy (20 mg) were
randomly allocated to policosanol (n=42) or placebo (n=45). At baseline, after 8 and 13 weeks,
markers of oxidative stress and antioxidant defence include total antioxidant status (TAS), total
oxidant status (TOS), advanced oxidation protein products (AOPP) and activity of superoxide
dismutase (SOD) were measured. Creatinine phosphokinase and hepatic enzymes were the
main safety endpoints. The mean age of the patients was 62.6 ± 0.8 years. Patients in
supplemented group had higher TAS and TOS levels 1640 (963–1752) vs 927 (481–1305),
[μmol/L], p < 0.001 and 18 (13––20) vs 6 (5–11), [μmol/L], p < 0.001], respectively, compared
to baseline. In placebo group, subjects had also higher TAS and TOS levels after 13-week
compared to baseline. SOD and AOPP were not influenced by the intervention. The
investigated supplement possessed a good safety profile. Combination of policosanol with
atorvastatin may be useful in an attempt to avoid potential adverse effects associated with
statins. 13-week supplementation was not sufficient to induce remarkably changes in SOD and
AOPP. TAS and TOS were increased in both groups.",
publisher = "University of Belgrade, Belgrade, Serbia",
journal = "Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade",
title = "May thirteen weeks of octacosanol supplementation affect prooxidant-antioxidant balance in patients on atorvastatin therapy",
pages = "15-15",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5395"
}

Zrnić-Ćirić, M., Kotur-Stevuljević, J., Baralić, I., Đorđević, B.,& Stanković, I.. (2020). May thirteen weeks of octacosanol supplementation affect prooxidant-antioxidant balance in patients on atorvastatin therapy. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade
University of Belgrade, Belgrade, Serbia., 15-15.
https://hdl.handle.net/21.15107/rcub_farfar_5395

Zrnić-Ćirić M, Kotur-Stevuljević J, Baralić I, Đorđević B, Stanković I. May thirteen weeks of octacosanol supplementation affect prooxidant-antioxidant balance in patients on atorvastatin therapy. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade. 2020;:15-15.
https://hdl.handle.net/21.15107/rcub_farfar_5395 .

Zrnić-Ćirić, Milica, Kotur-Stevuljević, Jelena, Baralić, Ivana, Đorđević, Brižita, Stanković, Ivan, "May thirteen weeks of octacosanol supplementation affect prooxidant-antioxidant balance in patients on atorvastatin therapy" in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade (2020):15-15,
https://hdl.handle.net/21.15107/rcub_farfar_5395 .

TY  - JOUR
AU  - Stanković, Ivan
AU  - Zrnić-Ćirić, Milica
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2965
AB  - Celiac disease (gluten sensitive enteropathy) is a chronic, lifelong inflammatory disease of the small intestine that occurs in genetically predisposed individuals, and is characterized by a permanent specific hypersensitivity to wheat, rye, barley and oat gluten. Gluten intake in these individuals leads to damage of the small intestine mucosa, which is manifested by abdominal problems, resulting in reduced absorption of nutrients, leading to secondary disorders and diseases such as rachitis, osteoporosis, arthritis, delay in growth and development, anemia, sterility, neurological disorders, skin changes, intestinal lymphomas. The prevalence of celiac disease is about 1% in the general population. The diagnostic procedure includes histological and serological tests, and a strict gluten-free diet is a lifelong treatment of celiac disease and is a main requirement for any further treatment of the consequences of nutritional deficits. The main problems in implementing a gluten-free diet is the presence of hidden gluten in food, medicines and cosmetics, and gluten contamination during production, storage and food preparation. According to the international Codex alimentarius standard (CODEX STAN 118-1979) and national regulations, gluten-free dietary products must not contain more than 20 mg/kg of gluten.
AB  - Celijačna bolest (gluten senzitivna enteropatija) je hronično doživotno inflamatorno oboljenje tankog creva koje se javlja kod genetski predisponiranih osoba, a odlikuje se trajnom specifičnom preosetljivošću na gluten pšenice, raži, ječma i ovsa. Unos glutena kod ovih osoba dovodi do oštećenja sluznice tankog creva koje se manifestuje abdominalnim problemima što rezultuje smanjenom apsorpcijom hranljivih sastojaka, što dalje uzrokuje razvoj sekundarnih poremećaja i oboljenja kao što su rahitis, osteoporoza, artritis, zastoj u rastu i razvoju, anemija, sterilitet, neurološki poremećaji, kožne promene, intestinalni limfomi dr. Prevalenca celijačne bolesti je oko 1% u opštoj populaciji. Dijagnostička procedura uključuje histološka i serološka ispitivanja a striktna dijeta bez glutena je doživotni tretman celijakije i uslovljava svako dalje lečenje posledica nutritivnih deficita. Najveći problem u sprovođenju dijete bez glutena je prisustvo skrivenog glutena u hrani, lekovima i kozmetičkim proizvodima i kontaminacija glutenom tokom proizvodnje, čuvanja i pripreme hrane. Prema međunarodnom standardu Codex alimentarius-a (CODEX STAN 118-1979) i nacionalnoj regulativi dijetetski proizvodi bez glutena ne smeju da sadrže više od 20 mg/kg glutena.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Celiac disease and dietetic products for persons intolerant to gluthen
T1  - Celijačna bolest i dijetetski proizvodi za osobe na dijeti bez gluten
VL  - 67
IS  - 2
SP  - 143
EP  - 149
DO  - 10.5937/arhfarm1702143S
ER  - 

@article{
author = "Stanković, Ivan and Zrnić-Ćirić, Milica",
year = "2017",
abstract = "Celiac disease (gluten sensitive enteropathy) is a chronic, lifelong inflammatory disease of the small intestine that occurs in genetically predisposed individuals, and is characterized by a permanent specific hypersensitivity to wheat, rye, barley and oat gluten. Gluten intake in these individuals leads to damage of the small intestine mucosa, which is manifested by abdominal problems, resulting in reduced absorption of nutrients, leading to secondary disorders and diseases such as rachitis, osteoporosis, arthritis, delay in growth and development, anemia, sterility, neurological disorders, skin changes, intestinal lymphomas. The prevalence of celiac disease is about 1% in the general population. The diagnostic procedure includes histological and serological tests, and a strict gluten-free diet is a lifelong treatment of celiac disease and is a main requirement for any further treatment of the consequences of nutritional deficits. The main problems in implementing a gluten-free diet is the presence of hidden gluten in food, medicines and cosmetics, and gluten contamination during production, storage and food preparation. According to the international Codex alimentarius standard (CODEX STAN 118-1979) and national regulations, gluten-free dietary products must not contain more than 20 mg/kg of gluten., Celijačna bolest (gluten senzitivna enteropatija) je hronično doživotno inflamatorno oboljenje tankog creva koje se javlja kod genetski predisponiranih osoba, a odlikuje se trajnom specifičnom preosetljivošću na gluten pšenice, raži, ječma i ovsa. Unos glutena kod ovih osoba dovodi do oštećenja sluznice tankog creva koje se manifestuje abdominalnim problemima što rezultuje smanjenom apsorpcijom hranljivih sastojaka, što dalje uzrokuje razvoj sekundarnih poremećaja i oboljenja kao što su rahitis, osteoporoza, artritis, zastoj u rastu i razvoju, anemija, sterilitet, neurološki poremećaji, kožne promene, intestinalni limfomi dr. Prevalenca celijačne bolesti je oko 1% u opštoj populaciji. Dijagnostička procedura uključuje histološka i serološka ispitivanja a striktna dijeta bez glutena je doživotni tretman celijakije i uslovljava svako dalje lečenje posledica nutritivnih deficita. Najveći problem u sprovođenju dijete bez glutena je prisustvo skrivenog glutena u hrani, lekovima i kozmetičkim proizvodima i kontaminacija glutenom tokom proizvodnje, čuvanja i pripreme hrane. Prema međunarodnom standardu Codex alimentarius-a (CODEX STAN 118-1979) i nacionalnoj regulativi dijetetski proizvodi bez glutena ne smeju da sadrže više od 20 mg/kg glutena.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Celiac disease and dietetic products for persons intolerant to gluthen, Celijačna bolest i dijetetski proizvodi za osobe na dijeti bez gluten",
volume = "67",
number = "2",
pages = "143-149",
doi = "10.5937/arhfarm1702143S"
}

Stanković, I.,& Zrnić-Ćirić, M.. (2017). Celiac disease and dietetic products for persons intolerant to gluthen. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 67(2), 143-149.
https://doi.org/10.5937/arhfarm1702143S

Stanković I, Zrnić-Ćirić M. Celiac disease and dietetic products for persons intolerant to gluthen. in Arhiv za farmaciju. 2017;67(2):143-149.
doi:10.5937/arhfarm1702143S .

Stanković, Ivan, Zrnić-Ćirić, Milica, "Celiac disease and dietetic products for persons intolerant to gluthen" in Arhiv za farmaciju, 67, no. 2 (2017):143-149,
https://doi.org/10.5937/arhfarm1702143S . .

TY  - JOUR
AU  - Delević, Veselin
AU  - Zejnilović, R.M
AU  - Jančić-Stojanović, Biljana
AU  - Đorđević, Brižita
AU  - Tokić, Z.N
AU  - Zrnić-Ćirić, Milica
AU  - Stanković, Ivan
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2730
AB  - Acrylamide is toxic and probably carcinogenic compound, made as a result of high-temperature thermal treatment of carbohydrate-rich foodstuffs. In this article a method is improved for the extraction and quantitation of acrylamide in foods produced based on corn flour that are represented in our traditional diet. Acrylamide extraction was carried out using reduced volume of saturated solution of bromine water and the GC–MS method for the quantification was shown. Quantification of acrylamide was preceded by: sample homogenization, acrylamide extraction using water, extract purification using solid phase extraction, bromination, using a reduced volume of bromine water solution, dehydrobromination with sodium thiosulfate and transformation of dibromopropenamide in 2,3,2-bromopropenamide using triethylamine. Regression and correlation analysis were applied for the probability level of 0.05. Calibration is performed in the concentration range 5–80 ug/kg with a detection limit 6.86 mg/kg and the limits of quantification 10.78 ug/kg and the coefficient of determination R2 > 0.999. Calibration curve was obtained: y = 0.069x + 0.038. Recovery values were an average from 97 to 110%. Proposed GC–MS method is simple, precise and reliable for the determination of acrylamide in the samples of thermal treated foods. Our results show that the tested foods quantify the presence of acrylamide in concentrations of 18 to 77 mg/kg acrylamide depending on whether the food was prepared by cooking or baking.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Quantification of acrylamide in foods selected by using gas chromatography tandem mass spectrometry
T1  - Kvantifikacija akrilamida u izabranim namirnicama primenom gasne hromatografije u tandemu sa masenom spektrometrijom
VL  - 70
IS  - 2
SP  - 209
EP  - 215
DO  - 10.2298/HEMIND150225027D
ER  - 

@article{
author = "Delević, Veselin and Zejnilović, R.M and Jančić-Stojanović, Biljana and Đorđević, Brižita and Tokić, Z.N and Zrnić-Ćirić, Milica and Stanković, Ivan",
year = "2016",
abstract = "Acrylamide is toxic and probably carcinogenic compound, made as a result of high-temperature thermal treatment of carbohydrate-rich foodstuffs. In this article a method is improved for the extraction and quantitation of acrylamide in foods produced based on corn flour that are represented in our traditional diet. Acrylamide extraction was carried out using reduced volume of saturated solution of bromine water and the GC–MS method for the quantification was shown. Quantification of acrylamide was preceded by: sample homogenization, acrylamide extraction using water, extract purification using solid phase extraction, bromination, using a reduced volume of bromine water solution, dehydrobromination with sodium thiosulfate and transformation of dibromopropenamide in 2,3,2-bromopropenamide using triethylamine. Regression and correlation analysis were applied for the probability level of 0.05. Calibration is performed in the concentration range 5–80 ug/kg with a detection limit 6.86 mg/kg and the limits of quantification 10.78 ug/kg and the coefficient of determination R2 > 0.999. Calibration curve was obtained: y = 0.069x + 0.038. Recovery values were an average from 97 to 110%. Proposed GC–MS method is simple, precise and reliable for the determination of acrylamide in the samples of thermal treated foods. Our results show that the tested foods quantify the presence of acrylamide in concentrations of 18 to 77 mg/kg acrylamide depending on whether the food was prepared by cooking or baking.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Quantification of acrylamide in foods selected by using gas chromatography tandem mass spectrometry, Kvantifikacija akrilamida u izabranim namirnicama primenom gasne hromatografije u tandemu sa masenom spektrometrijom",
volume = "70",
number = "2",
pages = "209-215",
doi = "10.2298/HEMIND150225027D"
}

Delević, V., Zejnilović, R.M, Jančić-Stojanović, B., Đorđević, B., Tokić, Z.N, Zrnić-Ćirić, M.,& Stanković, I.. (2016). Quantification of acrylamide in foods selected by using gas chromatography tandem mass spectrometry. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 70(2), 209-215.
https://doi.org/10.2298/HEMIND150225027D

Delević V, Zejnilović R, Jančić-Stojanović B, Đorđević B, Tokić Z, Zrnić-Ćirić M, Stanković I. Quantification of acrylamide in foods selected by using gas chromatography tandem mass spectrometry. in Hemijska industrija. 2016;70(2):209-215.
doi:10.2298/HEMIND150225027D .

Delević, Veselin, Zejnilović, R.M, Jančić-Stojanović, Biljana, Đorđević, Brižita, Tokić, Z.N, Zrnić-Ćirić, Milica, Stanković, Ivan, "Quantification of acrylamide in foods selected by using gas chromatography tandem mass spectrometry" in Hemijska industrija, 70, no. 2 (2016):209-215,
https://doi.org/10.2298/HEMIND150225027D . .

TY  - CONF
AU  - Konić-Ristić, Aleksandra
AU  - Zrnić-Ćirić, Milica
AU  - Stanković, Ivan
AU  - Srdić-Rajić, Tatjana
AU  - Kardum, Nevena
AU  - Glibetić, Marija
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5398
AB  - It has been suggested that impairment of intestinal wall integrity may contribute to the low-grade inflammation in subjects with metabolic distribances and foster progression of cardiovascular, liver or neurological diseases. Recent studies provide evidence that dietary polyphenols may important role in gut health and homeostasis, as one of the proposed mechanisms of their beneficial systemic effects.
PB  - Institut National de la Recherche Agronomique (INRA), France
PB  - Institut National de la Santé et de la Recherche Médicale (INSERM), France
C3  - 7th International Conference on Polyphenols and Health (ICPH 2015), 27 - 30 October 2015, Congress Center Tours, France
T1  - Long term consumption of Aronia juice decreases serum zonulin levels and the expression of cd11b on monocytes in subjects at high cvd risk
SP  - 198
EP  - 198
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5398
ER  - 

@conference{
author = "Konić-Ristić, Aleksandra and Zrnić-Ćirić, Milica and Stanković, Ivan and Srdić-Rajić, Tatjana and Kardum, Nevena and Glibetić, Marija",
year = "2015",
abstract = "It has been suggested that impairment of intestinal wall integrity may contribute to the low-grade inflammation in subjects with metabolic distribances and foster progression of cardiovascular, liver or neurological diseases. Recent studies provide evidence that dietary polyphenols may important role in gut health and homeostasis, as one of the proposed mechanisms of their beneficial systemic effects.",
publisher = "Institut National de la Recherche Agronomique (INRA), France, Institut National de la Santé et de la Recherche Médicale (INSERM), France",
journal = "7th International Conference on Polyphenols and Health (ICPH 2015), 27 - 30 October 2015, Congress Center Tours, France",
title = "Long term consumption of Aronia juice decreases serum zonulin levels and the expression of cd11b on monocytes in subjects at high cvd risk",
pages = "198-198",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5398"
}

Konić-Ristić, A., Zrnić-Ćirić, M., Stanković, I., Srdić-Rajić, T., Kardum, N.,& Glibetić, M.. (2015). Long term consumption of Aronia juice decreases serum zonulin levels and the expression of cd11b on monocytes in subjects at high cvd risk. in 7th International Conference on Polyphenols and Health (ICPH 2015), 27 - 30 October 2015, Congress Center Tours, France
Institut National de la Recherche Agronomique (INRA), France., 198-198.
https://hdl.handle.net/21.15107/rcub_farfar_5398

Konić-Ristić A, Zrnić-Ćirić M, Stanković I, Srdić-Rajić T, Kardum N, Glibetić M. Long term consumption of Aronia juice decreases serum zonulin levels and the expression of cd11b on monocytes in subjects at high cvd risk. in 7th International Conference on Polyphenols and Health (ICPH 2015), 27 - 30 October 2015, Congress Center Tours, France. 2015;:198-198.
https://hdl.handle.net/21.15107/rcub_farfar_5398 .

Konić-Ristić, Aleksandra, Zrnić-Ćirić, Milica, Stanković, Ivan, Srdić-Rajić, Tatjana, Kardum, Nevena, Glibetić, Marija, "Long term consumption of Aronia juice decreases serum zonulin levels and the expression of cd11b on monocytes in subjects at high cvd risk" in 7th International Conference on Polyphenols and Health (ICPH 2015), 27 - 30 October 2015, Congress Center Tours, France (2015):198-198,
https://hdl.handle.net/21.15107/rcub_farfar_5398 .

TY  - CONF
AU  - Đuričić, Ivana
AU  - Marinković, Danica
AU  - Dodevska, Margarita
AU  - Zrnić-Ćirić, Milica
AU  - Šobajić, Slađana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2345
AB  - Introduction: There is a growing number of epidemiological evidences that wholegrain products may reduce the risk of cardiovascular
diseases, type 2 diabetes, some forms of cancers, as well as obesity. The
beneficial health effects are due to the presence of many biologically
active compounds, which are located in the outer layer and germ fraction of the grain. Therefore, the higher intake of wholegrain foodstuffs
is recommended. Wholegrain bread, locally known as brown bread, is
the most common foodstuff of this type in Serbian diet.
Objectives: The objective of this paper was to assess the quality
indicators, basic chemical composition, and fiber profile of wholegrain
breads sampled from Belgrade supermarkets and bakeries.
Method / Design: In total 8 different samples of wholegrain
bread were analyzed. The nutritional quality of samples was evaluated by common physicochemical analyses (contents of protein, ash, water, crude fiber, acid degree, sodium chloride, starch). Enzymatic
methods were used for determination of fiber profile (resistant starch,
beta-glucan, fructans, and arabinoxylan). Also, sensory characteristics
were assessed.
Results: During evaluation of the sensory quality all samples
fulfilled the regulatory requirements. All analyzed samples received
high marks for each individual property of quality. However, the varia-
bility of acid degree, as well as some nutrient content (protein, crude
fiber, starch) among samples was great. On the other hand, other
parameters were similar between different bread samples (content of
water, ash, sodium chloride). The fiber fractions that were analyzed in
wholegrain bread samples revealed that resistant starch, fructans and
arabonoxylan were the major fiber fractions, while cellulose content
was unexpectedly low.
Conclusions: Obtained results indicated that wholegrain bread
from Belgrade market is of the standard quality and could be an important source of specific fiber fractions in everyday diet.
PB  - Karger, Basel
C3  - Annals of Nutrition and Metabolism
T1  - Chemical composition and nutritional quality of wholegrain bread from Belgrade market
VL  - 67
IS  - Supplement 1
SP  - 546
EP  - 547
DO  - 10.1159/000440895
ER  - 

@conference{
author = "Đuričić, Ivana and Marinković, Danica and Dodevska, Margarita and Zrnić-Ćirić, Milica and Šobajić, Slađana",
year = "2015",
abstract = "Introduction: There is a growing number of epidemiological evidences that wholegrain products may reduce the risk of cardiovascular
diseases, type 2 diabetes, some forms of cancers, as well as obesity. The
beneficial health effects are due to the presence of many biologically
active compounds, which are located in the outer layer and germ fraction of the grain. Therefore, the higher intake of wholegrain foodstuffs
is recommended. Wholegrain bread, locally known as brown bread, is
the most common foodstuff of this type in Serbian diet.
Objectives: The objective of this paper was to assess the quality
indicators, basic chemical composition, and fiber profile of wholegrain
breads sampled from Belgrade supermarkets and bakeries.
Method / Design: In total 8 different samples of wholegrain
bread were analyzed. The nutritional quality of samples was evaluated by common physicochemical analyses (contents of protein, ash, water, crude fiber, acid degree, sodium chloride, starch). Enzymatic
methods were used for determination of fiber profile (resistant starch,
beta-glucan, fructans, and arabinoxylan). Also, sensory characteristics
were assessed.
Results: During evaluation of the sensory quality all samples
fulfilled the regulatory requirements. All analyzed samples received
high marks for each individual property of quality. However, the varia-
bility of acid degree, as well as some nutrient content (protein, crude
fiber, starch) among samples was great. On the other hand, other
parameters were similar between different bread samples (content of
water, ash, sodium chloride). The fiber fractions that were analyzed in
wholegrain bread samples revealed that resistant starch, fructans and
arabonoxylan were the major fiber fractions, while cellulose content
was unexpectedly low.
Conclusions: Obtained results indicated that wholegrain bread
from Belgrade market is of the standard quality and could be an important source of specific fiber fractions in everyday diet.",
publisher = "Karger, Basel",
journal = "Annals of Nutrition and Metabolism",
title = "Chemical composition and nutritional quality of wholegrain bread from Belgrade market",
volume = "67",
number = "Supplement 1",
pages = "546-547",
doi = "10.1159/000440895"
}

Đuričić, I., Marinković, D., Dodevska, M., Zrnić-Ćirić, M.,& Šobajić, S.. (2015). Chemical composition and nutritional quality of wholegrain bread from Belgrade market. in Annals of Nutrition and Metabolism
Karger, Basel., 67(Supplement 1), 546-547.
https://doi.org/10.1159/000440895

Đuričić I, Marinković D, Dodevska M, Zrnić-Ćirić M, Šobajić S. Chemical composition and nutritional quality of wholegrain bread from Belgrade market. in Annals of Nutrition and Metabolism. 2015;67(Supplement 1):546-547.
doi:10.1159/000440895 .

Đuričić, Ivana, Marinković, Danica, Dodevska, Margarita, Zrnić-Ćirić, Milica, Šobajić, Slađana, "Chemical composition and nutritional quality of wholegrain bread from Belgrade market" in Annals of Nutrition and Metabolism, 67, no. Supplement 1 (2015):546-547,
https://doi.org/10.1159/000440895 . .

TY  - CONF
AU  - Koricanac, Vladimir
AU  - Vranić, Danijela
AU  - Lilić, Slobodan
AU  - Milicević, Dragan
AU  - Šobajić, Slađana
AU  - Zrnić-Ćirić, Milica
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2516
AB  - In the period January 2014 to March 2015, phosphorous levels were measured in 701 samples of different types of cooked sausages from the Serbian market. The highest level of phosphorus (9.52 g/kg, expressed as P2O5) was found in fine comminuted sausage, and the lowest (0.94 g/kg) in meat pate. The most common (33.38%) range of phosphorous levels was 4.01-5.00 g/kg P2O5. National Regulation allows total phosphorus content (as P2O5) up to 8.00 g/kg. Only three sausages (0.43%) did not meet this requirement, but the rest of the analyzed sausages (99.57%) were safe for consumption, with respect to content of phosphorus.
PB  - Elsevier Science BV, Amsterdam
C3  - 58th International Meat Industry Conference (MEATCON2015)
T1  - Total phosphorus content in various types of cooked sausages from the Serbian market
VL  - 5
SP  - 152
EP  - 155
DO  - 10.1016/j.profoo.2015.09.044
ER  - 

@conference{
author = "Koricanac, Vladimir and Vranić, Danijela and Lilić, Slobodan and Milicević, Dragan and Šobajić, Slađana and Zrnić-Ćirić, Milica",
year = "2015",
abstract = "In the period January 2014 to March 2015, phosphorous levels were measured in 701 samples of different types of cooked sausages from the Serbian market. The highest level of phosphorus (9.52 g/kg, expressed as P2O5) was found in fine comminuted sausage, and the lowest (0.94 g/kg) in meat pate. The most common (33.38%) range of phosphorous levels was 4.01-5.00 g/kg P2O5. National Regulation allows total phosphorus content (as P2O5) up to 8.00 g/kg. Only three sausages (0.43%) did not meet this requirement, but the rest of the analyzed sausages (99.57%) were safe for consumption, with respect to content of phosphorus.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "58th International Meat Industry Conference (MEATCON2015)",
title = "Total phosphorus content in various types of cooked sausages from the Serbian market",
volume = "5",
pages = "152-155",
doi = "10.1016/j.profoo.2015.09.044"
}

Koricanac, V., Vranić, D., Lilić, S., Milicević, D., Šobajić, S.,& Zrnić-Ćirić, M.. (2015). Total phosphorus content in various types of cooked sausages from the Serbian market. in 58th International Meat Industry Conference (MEATCON2015)
Elsevier Science BV, Amsterdam., 5, 152-155.
https://doi.org/10.1016/j.profoo.2015.09.044

Koricanac V, Vranić D, Lilić S, Milicević D, Šobajić S, Zrnić-Ćirić M. Total phosphorus content in various types of cooked sausages from the Serbian market. in 58th International Meat Industry Conference (MEATCON2015). 2015;5:152-155.
doi:10.1016/j.profoo.2015.09.044 .

Koricanac, Vladimir, Vranić, Danijela, Lilić, Slobodan, Milicević, Dragan, Šobajić, Slađana, Zrnić-Ćirić, Milica, "Total phosphorus content in various types of cooked sausages from the Serbian market" in 58th International Meat Industry Conference (MEATCON2015), 5 (2015):152-155,
https://doi.org/10.1016/j.profoo.2015.09.044 . .