TY  - JOUR
AU  - Milenković, Milica
AU  - Pevec, Andrej
AU  - Turel, Iztok
AU  - Milenković, Marina
AU  - Cobeljić, Božidar
AU  - Sladić, Dušan
AU  - Krstić, Natalija
AU  - Anđelković, Katarina
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3423
AB  - Square-planar isocyanate and chloride Ni(II) complexes with tridentate PNO condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent have been synthesized and their crystal structures were determined. These Ni(II) complexes with different monodentate ligands, chloride, cyanate, and thiocyanate were tested for their antimicrobial activities against pathogenic microorganisms. The ligand and Ni(II) complexes were active not only against laboratory control strains of bacteria and yeast, but also on clinical isolates of Escherichia coli and Pseudomonas aeruginosa strains resistant to most of the clinically used antibiotics.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Coordination Chemistry
T1  - Synthesis, crystal structures, and antimicrobial activity of square-planar chloride and isocyanate Ni(II) complexes with the condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent
VL  - 68
IS  - 16
SP  - 2858
EP  - 2870
DO  - 10.1080/00958972.2015.1055260
ER  - 

@article{
author = "Milenković, Milica and Pevec, Andrej and Turel, Iztok and Milenković, Marina and Cobeljić, Božidar and Sladić, Dušan and Krstić, Natalija and Anđelković, Katarina",
year = "2015",
abstract = "Square-planar isocyanate and chloride Ni(II) complexes with tridentate PNO condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent have been synthesized and their crystal structures were determined. These Ni(II) complexes with different monodentate ligands, chloride, cyanate, and thiocyanate were tested for their antimicrobial activities against pathogenic microorganisms. The ligand and Ni(II) complexes were active not only against laboratory control strains of bacteria and yeast, but also on clinical isolates of Escherichia coli and Pseudomonas aeruginosa strains resistant to most of the clinically used antibiotics.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Coordination Chemistry",
title = "Synthesis, crystal structures, and antimicrobial activity of square-planar chloride and isocyanate Ni(II) complexes with the condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent",
volume = "68",
number = "16",
pages = "2858-2870",
doi = "10.1080/00958972.2015.1055260"
}

Milenković, M., Pevec, A., Turel, I., Milenković, M., Cobeljić, B., Sladić, D., Krstić, N.,& Anđelković, K.. (2015). Synthesis, crystal structures, and antimicrobial activity of square-planar chloride and isocyanate Ni(II) complexes with the condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent. in Journal of Coordination Chemistry
Taylor & Francis Ltd, Abingdon., 68(16), 2858-2870.
https://doi.org/10.1080/00958972.2015.1055260

Milenković M, Pevec A, Turel I, Milenković M, Cobeljić B, Sladić D, Krstić N, Anđelković K. Synthesis, crystal structures, and antimicrobial activity of square-planar chloride and isocyanate Ni(II) complexes with the condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent. in Journal of Coordination Chemistry. 2015;68(16):2858-2870.
doi:10.1080/00958972.2015.1055260 .

Milenković, Milica, Pevec, Andrej, Turel, Iztok, Milenković, Marina, Cobeljić, Božidar, Sladić, Dušan, Krstić, Natalija, Anđelković, Katarina, "Synthesis, crystal structures, and antimicrobial activity of square-planar chloride and isocyanate Ni(II) complexes with the condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent" in Journal of Coordination Chemistry, 68, no. 16 (2015):2858-2870,
https://doi.org/10.1080/00958972.2015.1055260 . .

TY  - JOUR
AU  - Milenković, Milica
AU  - Pevec, Andrej
AU  - Turel, Iztok
AU  - Milenković, Marina
AU  - Cobeljić, Božidar
AU  - Sladić, Dušan
AU  - Krstić, Natalija
AU  - Anđelković, Katarina
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2441
AB  - Square-planar isocyanate and chloride Ni(II) complexes with tridentate PNO condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent have been synthesized and their crystal structures were determined. These Ni(II) complexes with different monodentate ligands, chloride, cyanate, and thiocyanate were tested for their antimicrobial activities against pathogenic microorganisms. The ligand and Ni(II) complexes were active not only against laboratory control strains of bacteria and yeast, but also on clinical isolates of Escherichia coli and Pseudomonas aeruginosa strains resistant to most of the clinically used antibiotics.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Coordination Chemistry
T1  - Synthesis, crystal structures, and antimicrobial activity of square-planar chloride and isocyanate Ni(II) complexes with the condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent
VL  - 68
IS  - 16
SP  - 2858
EP  - 2870
DO  - 10.1080/00958972.2015.1055260
ER  - 

@article{
author = "Milenković, Milica and Pevec, Andrej and Turel, Iztok and Milenković, Marina and Cobeljić, Božidar and Sladić, Dušan and Krstić, Natalija and Anđelković, Katarina",
year = "2015",
abstract = "Square-planar isocyanate and chloride Ni(II) complexes with tridentate PNO condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent have been synthesized and their crystal structures were determined. These Ni(II) complexes with different monodentate ligands, chloride, cyanate, and thiocyanate were tested for their antimicrobial activities against pathogenic microorganisms. The ligand and Ni(II) complexes were active not only against laboratory control strains of bacteria and yeast, but also on clinical isolates of Escherichia coli and Pseudomonas aeruginosa strains resistant to most of the clinically used antibiotics.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Coordination Chemistry",
title = "Synthesis, crystal structures, and antimicrobial activity of square-planar chloride and isocyanate Ni(II) complexes with the condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent",
volume = "68",
number = "16",
pages = "2858-2870",
doi = "10.1080/00958972.2015.1055260"
}

Milenković, M., Pevec, A., Turel, I., Milenković, M., Cobeljić, B., Sladić, D., Krstić, N.,& Anđelković, K.. (2015). Synthesis, crystal structures, and antimicrobial activity of square-planar chloride and isocyanate Ni(II) complexes with the condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent. in Journal of Coordination Chemistry
Taylor & Francis Ltd, Abingdon., 68(16), 2858-2870.
https://doi.org/10.1080/00958972.2015.1055260

Milenković M, Pevec A, Turel I, Milenković M, Cobeljić B, Sladić D, Krstić N, Anđelković K. Synthesis, crystal structures, and antimicrobial activity of square-planar chloride and isocyanate Ni(II) complexes with the condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent. in Journal of Coordination Chemistry. 2015;68(16):2858-2870.
doi:10.1080/00958972.2015.1055260 .

Milenković, Milica, Pevec, Andrej, Turel, Iztok, Milenković, Marina, Cobeljić, Božidar, Sladić, Dušan, Krstić, Natalija, Anđelković, Katarina, "Synthesis, crystal structures, and antimicrobial activity of square-planar chloride and isocyanate Ni(II) complexes with the condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent" in Journal of Coordination Chemistry, 68, no. 16 (2015):2858-2870,
https://doi.org/10.1080/00958972.2015.1055260 . .

TY  - JOUR
AU  - Milenković, Milica
AU  - Cantoni, Giulia
AU  - Bacchi, Alessia
AU  - Spasojević, Vojislav
AU  - Milenković, Marina
AU  - Sladić, Dušan
AU  - Krstić, Natalija
AU  - Anđelković, Katarina
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2103
AB  - Complexes of Pd(II) and Fe(III) with the condensation derivative of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate were synthesized, characterized, and their antimicrobial activity was evaluated. The structures of the Pd(II) and Fe(III) complexes in solid state were determined by IR, elemental analysis and X-ray analysis. The structure of Pd(II) complex in solution was determined by NMR spectroscopy. Results of magnetic measurements for Fe(III) complex were reported. In both complexes the ligand is coordinated as tridentate via the phosphorus, the imine nitrogen and the carbonyl oxygen atoms. Results of antimicrobial activity investigation indicate that the activity of the ligand is enhanced upon complexation, and that the MIC values of the iron complex to some bacterial strains are not much higher than those of cefotaxime.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Polyhedron
T1  - Synthesis, characterization and antimicrobial activity of Pd(II) and Fe(III) complexes with ethyl (2E)-2-[2-(diphenylphosphino)benzylidene]hydrazinecarboxylate
VL  - 80
SP  - 47
EP  - 52
DO  - 10.1016/j.poly.2014.01.022
ER  - 

@article{
author = "Milenković, Milica and Cantoni, Giulia and Bacchi, Alessia and Spasojević, Vojislav and Milenković, Marina and Sladić, Dušan and Krstić, Natalija and Anđelković, Katarina",
year = "2014",
abstract = "Complexes of Pd(II) and Fe(III) with the condensation derivative of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate were synthesized, characterized, and their antimicrobial activity was evaluated. The structures of the Pd(II) and Fe(III) complexes in solid state were determined by IR, elemental analysis and X-ray analysis. The structure of Pd(II) complex in solution was determined by NMR spectroscopy. Results of magnetic measurements for Fe(III) complex were reported. In both complexes the ligand is coordinated as tridentate via the phosphorus, the imine nitrogen and the carbonyl oxygen atoms. Results of antimicrobial activity investigation indicate that the activity of the ligand is enhanced upon complexation, and that the MIC values of the iron complex to some bacterial strains are not much higher than those of cefotaxime.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Polyhedron",
title = "Synthesis, characterization and antimicrobial activity of Pd(II) and Fe(III) complexes with ethyl (2E)-2-[2-(diphenylphosphino)benzylidene]hydrazinecarboxylate",
volume = "80",
pages = "47-52",
doi = "10.1016/j.poly.2014.01.022"
}

Milenković, M., Cantoni, G., Bacchi, A., Spasojević, V., Milenković, M., Sladić, D., Krstić, N.,& Anđelković, K.. (2014). Synthesis, characterization and antimicrobial activity of Pd(II) and Fe(III) complexes with ethyl (2E)-2-[2-(diphenylphosphino)benzylidene]hydrazinecarboxylate. in Polyhedron
Pergamon-Elsevier Science Ltd, Oxford., 80, 47-52.
https://doi.org/10.1016/j.poly.2014.01.022

Milenković M, Cantoni G, Bacchi A, Spasojević V, Milenković M, Sladić D, Krstić N, Anđelković K. Synthesis, characterization and antimicrobial activity of Pd(II) and Fe(III) complexes with ethyl (2E)-2-[2-(diphenylphosphino)benzylidene]hydrazinecarboxylate. in Polyhedron. 2014;80:47-52.
doi:10.1016/j.poly.2014.01.022 .

Milenković, Milica, Cantoni, Giulia, Bacchi, Alessia, Spasojević, Vojislav, Milenković, Marina, Sladić, Dušan, Krstić, Natalija, Anđelković, Katarina, "Synthesis, characterization and antimicrobial activity of Pd(II) and Fe(III) complexes with ethyl (2E)-2-[2-(diphenylphosphino)benzylidene]hydrazinecarboxylate" in Polyhedron, 80 (2014):47-52,
https://doi.org/10.1016/j.poly.2014.01.022 . .

TY  - JOUR
AU  - Cobeljić, Božidar
AU  - Pevec, Andrej
AU  - Turel, Iztok
AU  - Swart, Marcel
AU  - Mitić, Dragana
AU  - Milenković, Marina
AU  - Marković, Ivanka
AU  - Jovanović, Maja
AU  - Sladić, Dušan
AU  - Jeremić, Marko
AU  - Anđelković, Katarina
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1964
AB  - A Schiff base of 3-acetylpyridine with semicarbazide as well as the corresponding tetrahedral Zn(II) complex were synthesized and characterized by X-ray crystal structure analysis and spectroscopic methods. It is interesting to note that the ligand coordinated as a monodentate although there are several donor atoms in it. Computational studies showed that such structure is more stable than the hypothetical structure with one ligand bound as a bidentate. The complex exibited moderate antibacterial, antifungal and cytotoxic activities while the ligand was mostly inactive. The complex strongly induced formation of reactive oxygen species in tumor cell lines. It also influenced cell cycle progression in tumor cell lines, and induced autophagy. The latter effect is, at least in part, a protective one.
PB  - Elsevier Science Sa, Lausanne
T2  - Inorganica Chimica Acta
T1  - Synthesis, characterization, DFT calculations and biological activity of derivatives of 3-acetylpyridine and the zinc(II) complex with the condensation product of 3-acetylpyridine and semicarbazide
VL  - 404
SP  - 5
EP  - 12
DO  - 10.1016/j.ica.2013.04.017
ER  - 

@article{
author = "Cobeljić, Božidar and Pevec, Andrej and Turel, Iztok and Swart, Marcel and Mitić, Dragana and Milenković, Marina and Marković, Ivanka and Jovanović, Maja and Sladić, Dušan and Jeremić, Marko and Anđelković, Katarina",
year = "2013",
abstract = "A Schiff base of 3-acetylpyridine with semicarbazide as well as the corresponding tetrahedral Zn(II) complex were synthesized and characterized by X-ray crystal structure analysis and spectroscopic methods. It is interesting to note that the ligand coordinated as a monodentate although there are several donor atoms in it. Computational studies showed that such structure is more stable than the hypothetical structure with one ligand bound as a bidentate. The complex exibited moderate antibacterial, antifungal and cytotoxic activities while the ligand was mostly inactive. The complex strongly induced formation of reactive oxygen species in tumor cell lines. It also influenced cell cycle progression in tumor cell lines, and induced autophagy. The latter effect is, at least in part, a protective one.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Inorganica Chimica Acta",
title = "Synthesis, characterization, DFT calculations and biological activity of derivatives of 3-acetylpyridine and the zinc(II) complex with the condensation product of 3-acetylpyridine and semicarbazide",
volume = "404",
pages = "5-12",
doi = "10.1016/j.ica.2013.04.017"
}

Cobeljić, B., Pevec, A., Turel, I., Swart, M., Mitić, D., Milenković, M., Marković, I., Jovanović, M., Sladić, D., Jeremić, M.,& Anđelković, K.. (2013). Synthesis, characterization, DFT calculations and biological activity of derivatives of 3-acetylpyridine and the zinc(II) complex with the condensation product of 3-acetylpyridine and semicarbazide. in Inorganica Chimica Acta
Elsevier Science Sa, Lausanne., 404, 5-12.
https://doi.org/10.1016/j.ica.2013.04.017

Cobeljić B, Pevec A, Turel I, Swart M, Mitić D, Milenković M, Marković I, Jovanović M, Sladić D, Jeremić M, Anđelković K. Synthesis, characterization, DFT calculations and biological activity of derivatives of 3-acetylpyridine and the zinc(II) complex with the condensation product of 3-acetylpyridine and semicarbazide. in Inorganica Chimica Acta. 2013;404:5-12.
doi:10.1016/j.ica.2013.04.017 .

Cobeljić, Božidar, Pevec, Andrej, Turel, Iztok, Swart, Marcel, Mitić, Dragana, Milenković, Marina, Marković, Ivanka, Jovanović, Maja, Sladić, Dušan, Jeremić, Marko, Anđelković, Katarina, "Synthesis, characterization, DFT calculations and biological activity of derivatives of 3-acetylpyridine and the zinc(II) complex with the condensation product of 3-acetylpyridine and semicarbazide" in Inorganica Chimica Acta, 404 (2013):5-12,
https://doi.org/10.1016/j.ica.2013.04.017 . .

TY  - JOUR
AU  - Dražić, Branka
AU  - Popović, Gordana
AU  - Jelić, Ratomir
AU  - Sladić, Dušan
AU  - Mitić, Dragana
AU  - Anđelković, Katarina
AU  - Tešić, Živoslav
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1296
AB  - Acid-base equilibria of Zn(II) and Fe(III) complexes with N',N'2-bis- [(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (ligand L1) and N',N'2-bis[(1E)- -1-(2-pyridyl)ethylidene]propanedihydrazide (ligand L2), i.e., [Fe(L1)Cl2(H2O)], [Fe(L2)Cl(H2O)]2+, [Zn(L1)(H2O)3]+ and [Zn(L2)(H2O)2]2+, which expressed cytotoxic activity, were investigated in aqueous media. The equilibrium constants were determined potentiometrically at 25°C at a constant ionic strength of 0.10 mol/dm3 (Na2SO4). The results showed that at pH  lt  8 both the Fe(III) complexes studied here have three, while [Zn(L1)(H2O)3]+ and [Zn(L2)(H2O)2]2+ have one and two titratable protons, respectively. Based on the obtained values for the equilibrium constants, protonation schemes of the examined complexes are proposed.
AB  - U ovom radu su proučavane kiselinsko-bazne ravnoteže u vodenim rastvorima kompleksa Zn(II) i Fe(III) sa N',N'2-bis[(1E)-1-(2-piridil)etiliden]etandihidrazidom (ligand L1) i N',N'2-bis[(1E)-1-(2-piridil)etiliden]propandihidrazidom (ligand L2), tj. [Fe(L1)Cl2(H2O)], [Fe(L2)Cl(H2O)]2+, [Zn(L1)(H2O)3]+, [Zn(L2)(H2O)2]2+, koji pokazuju citotoksičnu aktivnost. Ravnotežne konstante su određivane potenciometrijski, na temperaturi 25°C i pri konstantnoj jonskoj jačini 0,10 mol/dm3 Na2SO4. Utvrđeno je da u intervalu pH  lt  8 ispitivani Fe(III) kompleksi imaju tri, [Zn(L1)(H2O)3]+ jedan, a [Zn(L2)(H2O)2]2+ dva protona koji mogu da se titrišu. Na osnovu dobijenih vrednosti za konstante, pretpostavljene su i odgovarajuće protonacione sheme.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid
T1  - Kiselinsko-bazne ravnoteže kompleksa Fe(III) i Zn(II) sa kondenzacionim derivatima 2-acetilpiridina i hidrazida oksalne, odnosno malonske kiseline
VL  - 74
IS  - 3
SP  - 269
EP  - 277
DO  - 10.2298/JSC0903269D
ER  - 

@article{
author = "Dražić, Branka and Popović, Gordana and Jelić, Ratomir and Sladić, Dušan and Mitić, Dragana and Anđelković, Katarina and Tešić, Živoslav",
year = "2009",
abstract = "Acid-base equilibria of Zn(II) and Fe(III) complexes with N',N'2-bis- [(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (ligand L1) and N',N'2-bis[(1E)- -1-(2-pyridyl)ethylidene]propanedihydrazide (ligand L2), i.e., [Fe(L1)Cl2(H2O)], [Fe(L2)Cl(H2O)]2+, [Zn(L1)(H2O)3]+ and [Zn(L2)(H2O)2]2+, which expressed cytotoxic activity, were investigated in aqueous media. The equilibrium constants were determined potentiometrically at 25°C at a constant ionic strength of 0.10 mol/dm3 (Na2SO4). The results showed that at pH  lt  8 both the Fe(III) complexes studied here have three, while [Zn(L1)(H2O)3]+ and [Zn(L2)(H2O)2]2+ have one and two titratable protons, respectively. Based on the obtained values for the equilibrium constants, protonation schemes of the examined complexes are proposed., U ovom radu su proučavane kiselinsko-bazne ravnoteže u vodenim rastvorima kompleksa Zn(II) i Fe(III) sa N',N'2-bis[(1E)-1-(2-piridil)etiliden]etandihidrazidom (ligand L1) i N',N'2-bis[(1E)-1-(2-piridil)etiliden]propandihidrazidom (ligand L2), tj. [Fe(L1)Cl2(H2O)], [Fe(L2)Cl(H2O)]2+, [Zn(L1)(H2O)3]+, [Zn(L2)(H2O)2]2+, koji pokazuju citotoksičnu aktivnost. Ravnotežne konstante su određivane potenciometrijski, na temperaturi 25°C i pri konstantnoj jonskoj jačini 0,10 mol/dm3 Na2SO4. Utvrđeno je da u intervalu pH  lt  8 ispitivani Fe(III) kompleksi imaju tri, [Zn(L1)(H2O)3]+ jedan, a [Zn(L2)(H2O)2]2+ dva protona koji mogu da se titrišu. Na osnovu dobijenih vrednosti za konstante, pretpostavljene su i odgovarajuće protonacione sheme.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid, Kiselinsko-bazne ravnoteže kompleksa Fe(III) i Zn(II) sa kondenzacionim derivatima 2-acetilpiridina i hidrazida oksalne, odnosno malonske kiseline",
volume = "74",
number = "3",
pages = "269-277",
doi = "10.2298/JSC0903269D"
}

Dražić, B., Popović, G., Jelić, R., Sladić, D., Mitić, D., Anđelković, K.,& Tešić, Ž.. (2009). Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 74(3), 269-277.
https://doi.org/10.2298/JSC0903269D

Dražić B, Popović G, Jelić R, Sladić D, Mitić D, Anđelković K, Tešić Ž. Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid. in Journal of the Serbian Chemical Society. 2009;74(3):269-277.
doi:10.2298/JSC0903269D .

Dražić, Branka, Popović, Gordana, Jelić, Ratomir, Sladić, Dušan, Mitić, Dragana, Anđelković, Katarina, Tešić, Živoslav, "Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid" in Journal of the Serbian Chemical Society, 74, no. 3 (2009):269-277,
https://doi.org/10.2298/JSC0903269D . .

TY  - JOUR
AU  - Vojić, Mirjana P.
AU  - Popović, Gordana
AU  - Sladić, Dušan
AU  - Pfendt, Lidija
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/659
AB  - The acid-base equilibria of a diprotic, slightly hydrosoluble base ketoconazole were studied in homogeneous and heterogeneous water systems. The determinations were performed at 25ºC at a constant ionic strength of M(NaCl). The acidity constant Ka1 was determined by potentiometric (pKa1 3.20) and spectrophotometric (pKa1 3.26) methods. A pKa2 constant of 6.10 was obtained based on the equilibrium constants pKs0 4.84 and pKs1 -1.26, determined in a heterogeneous ketoconazole system. The obtained values of the constants served to calculate the solubility and the distribution of the equilibrium forms of ketoconazole as a function of pH. On the basis of the distribution of the equilibrium forms of ketoconazole, a spectrophotometric method for the determination of its content in commercial tablets was developed. The determinations were performed at 225 nm in 0.1 M HCl. The method is simple and rapid and enables the direct spectrophotometric determination of the content of ketoconazole without previous isolation.
AB  - Proučene su kiselinsko-bazne ravnoteže u homogenom i heterogenom vodenom sistemu ketokonazola, diprotične teško rastvorne baze. Određivanja su vršena na temperaturi 25ºC i pri konstantnoj jonskoj sili 0,1M(NaCl). Kiselinska konstantaKa1 određena je potenciometrijski (pKa1 3,20) i spektrofotometrijski (pKa1 3,26). Konstanta pKa2 6,10 izračunata je iz ravnotežnih konstanti određenih u heterogenom sistemu: pKs0 4,84 i pKs1 -1,26. Na osnovu dobijenih vrednosti za konstante izračunata je rastvorljivost i raspodela ravnotežnih oblika ketokonazola u funkciji pH. Na bazi raspodele ravnotežnih oblika ketokonazola predložena je spektrofotometrijska metoda za njegovo određivanje u komercijalnim tabletama. Određivanja su vršena na talasnoj dužini 225 nm u 0,1M HCl.Metoda je jednostavna i brza, i omogućava direktno spektrofotometrijsko određivanje ketokonazola, bez prethodnog izolovanja.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Protolytic equilibria in homogeneous and heterogeneous systems of ketoconazole and its direct spectrophotometric determination in tablets
T1  - Protolitičke ravnoteže u homogenom i heterogenom sistemu ketokonazola i njegovo direktno spektrofotometrijsko određivanje u tabletama
VL  - 70
IS  - 1
SP  - 67
EP  - 78
DO  - 10.2298/JSC0501067V
ER  - 

@article{
author = "Vojić, Mirjana P. and Popović, Gordana and Sladić, Dušan and Pfendt, Lidija",
year = "2005",
abstract = "The acid-base equilibria of a diprotic, slightly hydrosoluble base ketoconazole were studied in homogeneous and heterogeneous water systems. The determinations were performed at 25ºC at a constant ionic strength of M(NaCl). The acidity constant Ka1 was determined by potentiometric (pKa1 3.20) and spectrophotometric (pKa1 3.26) methods. A pKa2 constant of 6.10 was obtained based on the equilibrium constants pKs0 4.84 and pKs1 -1.26, determined in a heterogeneous ketoconazole system. The obtained values of the constants served to calculate the solubility and the distribution of the equilibrium forms of ketoconazole as a function of pH. On the basis of the distribution of the equilibrium forms of ketoconazole, a spectrophotometric method for the determination of its content in commercial tablets was developed. The determinations were performed at 225 nm in 0.1 M HCl. The method is simple and rapid and enables the direct spectrophotometric determination of the content of ketoconazole without previous isolation., Proučene su kiselinsko-bazne ravnoteže u homogenom i heterogenom vodenom sistemu ketokonazola, diprotične teško rastvorne baze. Određivanja su vršena na temperaturi 25ºC i pri konstantnoj jonskoj sili 0,1M(NaCl). Kiselinska konstantaKa1 određena je potenciometrijski (pKa1 3,20) i spektrofotometrijski (pKa1 3,26). Konstanta pKa2 6,10 izračunata je iz ravnotežnih konstanti određenih u heterogenom sistemu: pKs0 4,84 i pKs1 -1,26. Na osnovu dobijenih vrednosti za konstante izračunata je rastvorljivost i raspodela ravnotežnih oblika ketokonazola u funkciji pH. Na bazi raspodele ravnotežnih oblika ketokonazola predložena je spektrofotometrijska metoda za njegovo određivanje u komercijalnim tabletama. Određivanja su vršena na talasnoj dužini 225 nm u 0,1M HCl.Metoda je jednostavna i brza, i omogućava direktno spektrofotometrijsko određivanje ketokonazola, bez prethodnog izolovanja.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Protolytic equilibria in homogeneous and heterogeneous systems of ketoconazole and its direct spectrophotometric determination in tablets, Protolitičke ravnoteže u homogenom i heterogenom sistemu ketokonazola i njegovo direktno spektrofotometrijsko određivanje u tabletama",
volume = "70",
number = "1",
pages = "67-78",
doi = "10.2298/JSC0501067V"
}

Vojić, M. P., Popović, G., Sladić, D.,& Pfendt, L.. (2005). Protolytic equilibria in homogeneous and heterogeneous systems of ketoconazole and its direct spectrophotometric determination in tablets. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 70(1), 67-78.
https://doi.org/10.2298/JSC0501067V

Vojić MP, Popović G, Sladić D, Pfendt L. Protolytic equilibria in homogeneous and heterogeneous systems of ketoconazole and its direct spectrophotometric determination in tablets. in Journal of the Serbian Chemical Society. 2005;70(1):67-78.
doi:10.2298/JSC0501067V .

Vojić, Mirjana P., Popović, Gordana, Sladić, Dušan, Pfendt, Lidija, "Protolytic equilibria in homogeneous and heterogeneous systems of ketoconazole and its direct spectrophotometric determination in tablets" in Journal of the Serbian Chemical Society, 70, no. 1 (2005):67-78,
https://doi.org/10.2298/JSC0501067V . .

TY  - JOUR
AU  - Popović, Gordana
AU  - Sladić, Dušan
AU  - Stefanović, Violeta M.
AU  - Pfendt, Lidija
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/418
AB  - Protolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 degreesC and ionic strength of 0.1 M. Acidity constants and equilibrium constants in a heterogeneous system were determined. On the basis of the analysis of the corresponding C-13- and H-1-NMR spectra, deprotonation site in the molecules of the investigated compounds was predicted. Finally, the correlation between chemical shifts in the H-1-NMR spectra and the acidity of the amide proton of 1,4-benzodiazepines was established.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy
VL  - 31
IS  - 4
SP  - 693
EP  - 699
DO  - 10.1016/S0731-7085(02)00686-6
ER  - 

@article{
author = "Popović, Gordana and Sladić, Dušan and Stefanović, Violeta M. and Pfendt, Lidija",
year = "2003",
abstract = "Protolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 degreesC and ionic strength of 0.1 M. Acidity constants and equilibrium constants in a heterogeneous system were determined. On the basis of the analysis of the corresponding C-13- and H-1-NMR spectra, deprotonation site in the molecules of the investigated compounds was predicted. Finally, the correlation between chemical shifts in the H-1-NMR spectra and the acidity of the amide proton of 1,4-benzodiazepines was established.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy",
volume = "31",
number = "4",
pages = "693-699",
doi = "10.1016/S0731-7085(02)00686-6"
}

Popović, G., Sladić, D., Stefanović, V. M.,& Pfendt, L.. (2003). Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 31(4), 693-699.
https://doi.org/10.1016/S0731-7085(02)00686-6

Popović G, Sladić D, Stefanović VM, Pfendt L. Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy. in Journal of Pharmaceutical and Biomedical Analysis. 2003;31(4):693-699.
doi:10.1016/S0731-7085(02)00686-6 .

Popović, Gordana, Sladić, Dušan, Stefanović, Violeta M., Pfendt, Lidija, "Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy" in Journal of Pharmaceutical and Biomedical Analysis, 31, no. 4 (2003):693-699,
https://doi.org/10.1016/S0731-7085(02)00686-6 . .

TY  - JOUR
AU  - Pfendt, Lidija
AU  - Popović, Gordana
AU  - Damjanović, Tatjana
AU  - Sladić, Dušan
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/395
AB  - The protolytic equilibria of bromazepam, an ampholyte sparingly soluble in water, in homogeneous and heterogeneous systems were studied in the pH range 0–14 at 25ºC and at ionic strength of 0.1 mol/dm3 (NaCl). On the basis of 13C-NMR spectra, the protonation site was predicted – in acidic media the pyridine nitrogen of bormazepam is protonated. The acidity constants of bromazepam were determined spectrophotometrically (pKa1 2.83 and pKa2 11.60) and potentiometrically (pKa1 2.99). In the heterogeneous system the following equilibrium constants were determined: Ks0 =[HA](pKs0 3.44), Ks1 =[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04).
AB  - Proučavane su protolitičke ravnoteže bromazepama, amfolita iz klase 1,4-benzodiazepina, slabo rastvornog u vodi. Ispitivanja su vršena u homogenom i heterogenom sistemu u pH intervalu 0–14, na temperaturi 25ºC i pri jonskoj sili 0,1 mol/dm3 (NaCl). Na osnovu 13C-NMR spektara pretpostavljeno je da do protonovanja u molekulu bromazepama dolazi na piridinskom atomu azota. Kiselinske konstante određene su spektrofotometrijski (pKa1 2.83 and pKa2 11.60) i potenciometrijski (pKa1 2,99). U heterogenom sistemu određene su sledeće ravnotežne konstante Ks0 =[HA](pKs0 3.44), Ks1=[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04).
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Protolytic equlibria of bromazepam
T1  - Protolitičke ravnoteže bromazepama
VL  - 67
IS  - 3
SP  - 187
EP  - 195
DO  - 10.2298/JSC0203187P
ER  - 

@article{
author = "Pfendt, Lidija and Popović, Gordana and Damjanović, Tatjana and Sladić, Dušan",
year = "2002",
abstract = "The protolytic equilibria of bromazepam, an ampholyte sparingly soluble in water, in homogeneous and heterogeneous systems were studied in the pH range 0–14 at 25ºC and at ionic strength of 0.1 mol/dm3 (NaCl). On the basis of 13C-NMR spectra, the protonation site was predicted – in acidic media the pyridine nitrogen of bormazepam is protonated. The acidity constants of bromazepam were determined spectrophotometrically (pKa1 2.83 and pKa2 11.60) and potentiometrically (pKa1 2.99). In the heterogeneous system the following equilibrium constants were determined: Ks0 =[HA](pKs0 3.44), Ks1 =[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04)., Proučavane su protolitičke ravnoteže bromazepama, amfolita iz klase 1,4-benzodiazepina, slabo rastvornog u vodi. Ispitivanja su vršena u homogenom i heterogenom sistemu u pH intervalu 0–14, na temperaturi 25ºC i pri jonskoj sili 0,1 mol/dm3 (NaCl). Na osnovu 13C-NMR spektara pretpostavljeno je da do protonovanja u molekulu bromazepama dolazi na piridinskom atomu azota. Kiselinske konstante određene su spektrofotometrijski (pKa1 2.83 and pKa2 11.60) i potenciometrijski (pKa1 2,99). U heterogenom sistemu određene su sledeće ravnotežne konstante Ks0 =[HA](pKs0 3.44), Ks1=[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04).",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Protolytic equlibria of bromazepam, Protolitičke ravnoteže bromazepama",
volume = "67",
number = "3",
pages = "187-195",
doi = "10.2298/JSC0203187P"
}

Pfendt, L., Popović, G., Damjanović, T.,& Sladić, D.. (2002). Protolytic equlibria of bromazepam. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 67(3), 187-195.
https://doi.org/10.2298/JSC0203187P

Pfendt L, Popović G, Damjanović T, Sladić D. Protolytic equlibria of bromazepam. in Journal of the Serbian Chemical Society. 2002;67(3):187-195.
doi:10.2298/JSC0203187P .

Pfendt, Lidija, Popović, Gordana, Damjanović, Tatjana, Sladić, Dušan, "Protolytic equlibria of bromazepam" in Journal of the Serbian Chemical Society, 67, no. 3 (2002):187-195,
https://doi.org/10.2298/JSC0203187P . .

TY  - CONF
AU  - Popović, Gordana
AU  - Damjanović, Tatjana
AU  - Sladić, Dušan
AU  - Pfendt, Lidija
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/310
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Identification of the diazepine ring opening site in the reaction of acidic hydrolysis of bromazepam
T1  - Identifikacija mesta hidrolitičkog otvaranja diazepinskog prstena bromazepama u kiseloj sredini
VL  - 52
IS  - 4
SP  - 462
EP  - 463
UR  - https://hdl.handle.net/21.15107/rcub_farfar_310
ER  - 

@conference{
author = "Popović, Gordana and Damjanović, Tatjana and Sladić, Dušan and Pfendt, Lidija",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Identification of the diazepine ring opening site in the reaction of acidic hydrolysis of bromazepam, Identifikacija mesta hidrolitičkog otvaranja diazepinskog prstena bromazepama u kiseloj sredini",
volume = "52",
number = "4",
pages = "462-463",
url = "https://hdl.handle.net/21.15107/rcub_farfar_310"
}

Popović, G., Damjanović, T., Sladić, D.,& Pfendt, L.. (2002). Identification of the diazepine ring opening site in the reaction of acidic hydrolysis of bromazepam. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 462-463.
https://hdl.handle.net/21.15107/rcub_farfar_310

Popović G, Damjanović T, Sladić D, Pfendt L. Identification of the diazepine ring opening site in the reaction of acidic hydrolysis of bromazepam. in Arhiv za farmaciju. 2002;52(4):462-463.
https://hdl.handle.net/21.15107/rcub_farfar_310 .

Popović, Gordana, Damjanović, Tatjana, Sladić, Dušan, Pfendt, Lidija, "Identification of the diazepine ring opening site in the reaction of acidic hydrolysis of bromazepam" in Arhiv za farmaciju, 52, no. 4 (2002):462-463,
https://hdl.handle.net/21.15107/rcub_farfar_310 .

TY  - JOUR
AU  - Pfendt, Lidija
AU  - Sladić, Dušan
AU  - Janjić, T.J
AU  - Popović, Gordana
PY  - 1990
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/76
AB  - Acid-base equilibria in heterogeneous and homogeneous systems of some sparingly soluble benzodiazepines (diazepam, prazepam, chlordiazepoxide and medazepam) were investigated in aqueous solution and the corresponding equilibrium constants were determined by the application of pH-metric, spectrophotometric and solubility methods. The sites of protonation were predicted on the basis of the analysis of the corresponding carbon-13 nuclear magnetic resonance spectra. In addition, buffer characteristics of saturated aqueous solutions of these drugs in the presence of the solid phase were investigated and it was established that they possess a very high buffer capacity over a specific pH range.
T2  - The Analyst
T1  - Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines
VL  - 115
IS  - 4
SP  - 383
EP  - 387
DO  - 10.1039/an9901500383
ER  - 

@article{
author = "Pfendt, Lidija and Sladić, Dušan and Janjić, T.J and Popović, Gordana",
year = "1990",
abstract = "Acid-base equilibria in heterogeneous and homogeneous systems of some sparingly soluble benzodiazepines (diazepam, prazepam, chlordiazepoxide and medazepam) were investigated in aqueous solution and the corresponding equilibrium constants were determined by the application of pH-metric, spectrophotometric and solubility methods. The sites of protonation were predicted on the basis of the analysis of the corresponding carbon-13 nuclear magnetic resonance spectra. In addition, buffer characteristics of saturated aqueous solutions of these drugs in the presence of the solid phase were investigated and it was established that they possess a very high buffer capacity over a specific pH range.",
journal = "The Analyst",
title = "Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines",
volume = "115",
number = "4",
pages = "383-387",
doi = "10.1039/an9901500383"
}

Pfendt, L., Sladić, D., Janjić, T.J,& Popović, G.. (1990). Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines. in The Analyst, 115(4), 383-387.
https://doi.org/10.1039/an9901500383

Pfendt L, Sladić D, Janjić T, Popović G. Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines. in The Analyst. 1990;115(4):383-387.
doi:10.1039/an9901500383 .

Pfendt, Lidija, Sladić, Dušan, Janjić, T.J, Popović, Gordana, "Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines" in The Analyst, 115, no. 4 (1990):383-387,
https://doi.org/10.1039/an9901500383 . .