TY  - CONF
AU  - Leković, Aleksandra
AU  - Samardžić, Stevan
AU  - Radović-Selgrad, Jelena
AU  - Kundaković-Vasović, Tatjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4584
AB  - Sorbus torminalis (L.) Crantz (Rosaceae), also known as wild service tree, is a
deciduous tree widespread in central and southern Europe, north-western Africa, western
Asia, the Balkan Peninsula and the Caucasus (1, 2). Species of the genus Sorbus represent a
rich source of polyphenols that are responsible for their numerous proven effects, including
anti-diarrhoeal, anti-inflammatory, antidiabetic, antioxidant and anti-atherogenic effect.
Accordingly, the bark of S. torminalis could have interesting composition and effects,
however, data about this herbal drug is insufficient (1). Bark dry methanol extract (DER
9.74:1), obtained after successive extraction with cyclohexane and dichloromethane, was
analyzed for antioxidant potential using DPPH and FRAP assay. Contents of total
polyphenols, flavonoids and tannins were determined using spectrophotometric methods
based on reaction with Folin-Ciocalteu reagent (FC), reaction with aluminum-chloride and
adsorption by hide powder in combination with reaction with FC, respectively. LC-DAD-ESI-
MS analysis was used for identification of main extract constituents. In DPPH test IC50 value
8.66±0.07 μg/mL was shown, while result of FRAP test was 3.01±0.11 μmol Fe 2+ /mg of dry
extract. Contents of total polyphenols, flavonoids and tannins were 0.39±0.06 mg GA/mg of
dry extract, 0.035±0.019% and 1.3±0.08%, respectively. By LC-DAD-ESI-MS analysis 25
compounds were detected among which procyanidins (dimers, trimers and tetramers) are
dominant. The results of this study showed that dry methanol extract of S. torminalis bark is
rich in procyanidins which potentially contribute to its antioxidant activity. Additional
significant effects of this herbal drug and its isolated compounds should be investigated in
future studies.
AB  - Sorbus torminalis (L.) Crantz (Rosaceae) je listopadno drvo, u narodu poznato pod
nazivom brekinja. Rasprostranjeno je širom centralne i južne Evrope, severozapadne Afrike,
zapadne Azije, Balkanskog poluostrva i Kavkaza (1, 2). Vrste roda Sorbus predstavljaju bogat
izvor polifenola koji su odgovorni za njihove brojne dokazane efekte, uključuju antidijaroični,
antiinflamatorni, antidijabetski, antioksidantni i antiaterogeni efekat. U skladu sa tim, kora S.
torminalis mogla bi imati interesantan sastav i efekte, međutim, o ovoj biljnoj drogi nema
dovoljno podataka (1). Antioksidantna aktivnost suvog metanolnog ekstrakta kore stabla
(DER 9,74:1), dobijenog nakon sukcesivne ekstrakcije cikloheksanom i dihlormetanom,
analizirana je DPPH i FRAP testom. Sadržaji ukupnih polifenola, flavonoida i tanina određeni
su spektrofotometrijskim metodama koje se zasnivaju na reakciji sa Folin‐Ciocalteu
reagensom (FC), reakciji sa aluminijum-hloridom i na adsorpciji na kožni prah u kombinaciji
sa reakcijom sa FC reagensom, redom. LC‐DAD‐ESI‐MS analiza korišćena je za identifikaciju
glavnih sastojaka ekstrakta. U DPPH testu dobijena je IC50 vrednost 8,66±0,07 μg/mL, a
rezultat FRAP testa bio je 3,01±0,11 μmol Fe 2+ /mg suvog ekstrakta. Sadžaj ukupnih
polifenola bio je 0,39±0,06 mg GA/mg suvog ekstrakta, flavonoida 0,035±0,019%, a tanina
1,3±0,08%. LC‐DAD‐ESI‐MS analizom detektovano je 25 jedinjenja od kojih su dominantni
procijanidini (dimeri, trimeri i tetrameri). Rezultati ovog istraživanja pokazali su da je suvi
metanolni ekstrakt kore stabla S. torminalis bogat procijanidinima koji potencijalno
doprinose njegovoj antioksidantnoj aktivnosti. Dodatne značajne efekte ove biljne droge i
njenih izolovanih jedinjenja trebalo bi ispitati u budućim istraživanjima.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Chemical composition and antioxidant activity of Sorbus torminalis bark methanol extract
T1  - Hemijski sastav i antioksidantna aktivnost metanolnog ekstrakta kore stabla Sorbus torminalis
VL  - 72
IS  - 4 suplement
SP  - S467
EP  - S468
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4584
ER  - 

@conference{
author = "Leković, Aleksandra and Samardžić, Stevan and Radović-Selgrad, Jelena and Kundaković-Vasović, Tatjana",
year = "2022",
abstract = "Sorbus torminalis (L.) Crantz (Rosaceae), also known as wild service tree, is a
deciduous tree widespread in central and southern Europe, north-western Africa, western
Asia, the Balkan Peninsula and the Caucasus (1, 2). Species of the genus Sorbus represent a
rich source of polyphenols that are responsible for their numerous proven effects, including
anti-diarrhoeal, anti-inflammatory, antidiabetic, antioxidant and anti-atherogenic effect.
Accordingly, the bark of S. torminalis could have interesting composition and effects,
however, data about this herbal drug is insufficient (1). Bark dry methanol extract (DER
9.74:1), obtained after successive extraction with cyclohexane and dichloromethane, was
analyzed for antioxidant potential using DPPH and FRAP assay. Contents of total
polyphenols, flavonoids and tannins were determined using spectrophotometric methods
based on reaction with Folin-Ciocalteu reagent (FC), reaction with aluminum-chloride and
adsorption by hide powder in combination with reaction with FC, respectively. LC-DAD-ESI-
MS analysis was used for identification of main extract constituents. In DPPH test IC50 value
8.66±0.07 μg/mL was shown, while result of FRAP test was 3.01±0.11 μmol Fe 2+ /mg of dry
extract. Contents of total polyphenols, flavonoids and tannins were 0.39±0.06 mg GA/mg of
dry extract, 0.035±0.019% and 1.3±0.08%, respectively. By LC-DAD-ESI-MS analysis 25
compounds were detected among which procyanidins (dimers, trimers and tetramers) are
dominant. The results of this study showed that dry methanol extract of S. torminalis bark is
rich in procyanidins which potentially contribute to its antioxidant activity. Additional
significant effects of this herbal drug and its isolated compounds should be investigated in
future studies., Sorbus torminalis (L.) Crantz (Rosaceae) je listopadno drvo, u narodu poznato pod
nazivom brekinja. Rasprostranjeno je širom centralne i južne Evrope, severozapadne Afrike,
zapadne Azije, Balkanskog poluostrva i Kavkaza (1, 2). Vrste roda Sorbus predstavljaju bogat
izvor polifenola koji su odgovorni za njihove brojne dokazane efekte, uključuju antidijaroični,
antiinflamatorni, antidijabetski, antioksidantni i antiaterogeni efekat. U skladu sa tim, kora S.
torminalis mogla bi imati interesantan sastav i efekte, međutim, o ovoj biljnoj drogi nema
dovoljno podataka (1). Antioksidantna aktivnost suvog metanolnog ekstrakta kore stabla
(DER 9,74:1), dobijenog nakon sukcesivne ekstrakcije cikloheksanom i dihlormetanom,
analizirana je DPPH i FRAP testom. Sadržaji ukupnih polifenola, flavonoida i tanina određeni
su spektrofotometrijskim metodama koje se zasnivaju na reakciji sa Folin‐Ciocalteu
reagensom (FC), reakciji sa aluminijum-hloridom i na adsorpciji na kožni prah u kombinaciji
sa reakcijom sa FC reagensom, redom. LC‐DAD‐ESI‐MS analiza korišćena je za identifikaciju
glavnih sastojaka ekstrakta. U DPPH testu dobijena je IC50 vrednost 8,66±0,07 μg/mL, a
rezultat FRAP testa bio je 3,01±0,11 μmol Fe 2+ /mg suvog ekstrakta. Sadžaj ukupnih
polifenola bio je 0,39±0,06 mg GA/mg suvog ekstrakta, flavonoida 0,035±0,019%, a tanina
1,3±0,08%. LC‐DAD‐ESI‐MS analizom detektovano je 25 jedinjenja od kojih su dominantni
procijanidini (dimeri, trimeri i tetrameri). Rezultati ovog istraživanja pokazali su da je suvi
metanolni ekstrakt kore stabla S. torminalis bogat procijanidinima koji potencijalno
doprinose njegovoj antioksidantnoj aktivnosti. Dodatne značajne efekte ove biljne droge i
njenih izolovanih jedinjenja trebalo bi ispitati u budućim istraživanjima.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Chemical composition and antioxidant activity of Sorbus torminalis bark methanol extract, Hemijski sastav i antioksidantna aktivnost metanolnog ekstrakta kore stabla Sorbus torminalis",
volume = "72",
number = "4 suplement",
pages = "S467-S468",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4584"
}

Leković, A., Samardžić, S., Radović-Selgrad, J.,& Kundaković-Vasović, T.. (2022). Chemical composition and antioxidant activity of Sorbus torminalis bark methanol extract. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S467-S468.
https://hdl.handle.net/21.15107/rcub_farfar_4584

Leković A, Samardžić S, Radović-Selgrad J, Kundaković-Vasović T. Chemical composition and antioxidant activity of Sorbus torminalis bark methanol extract. in Arhiv za farmaciju. 2022;72(4 suplement):S467-S468.
https://hdl.handle.net/21.15107/rcub_farfar_4584 .

Leković, Aleksandra, Samardžić, Stevan, Radović-Selgrad, Jelena, Kundaković-Vasović, Tatjana, "Chemical composition and antioxidant activity of Sorbus torminalis bark methanol extract" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S467-S468,
https://hdl.handle.net/21.15107/rcub_farfar_4584 .

TY  - JOUR
AU  - Radović, Jelena
AU  - Leković, Aleksandra
AU  - Damjanović, Ana B.
AU  - Kopanja, Đurđica
AU  - Dodevska, Margarita
AU  - Stanojković, Tatjana
AU  - Marinković, Tijana
AU  - Jelić, Čedomir
AU  - Kundaković-Vasović, Tatjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5057
AB  - The composition of biologically active compounds of Calocybe gambosa (Lyophyllaceae) was analysed, and
the antioxidant and cytotoxic activities were tested in vitro. C. gambosa was low in energy, fat, and car-
bohydrates, but rich in proteins and fibres. The total polyphenol content in the extracts was low (23.08 ±
0.67 in aqueous and 24.99 ± 4.25 mg GA mg 1 of extract in methanolic extract). The methanolic extract
showed anti-DPPH radical activity with an IC 50 of 626.10 ± 25.20 mg mL 1 . The sample of C. gambosa is
rich in nucleotides and amino acids responsible for its pleasant taste. The nucleoside and 50-mono-
phosphates contents were 0.97 mg g 1 and 2.32 mg g 1 of dry mushroom, respectively. The contents of
essential and non-essential amino acids were 18.41 ± 0.06 and 41.75 ± 0.30 mg g 1 d.w., respectively. The
percentages of saturated and unsaturated fatty acids were 42.6% and 57.4%, respectively. The most
abundant water-soluble and fat-soluble vitamins were B1 and E, respectively. Cytotoxic effect of the extracts was examined against different cancer cell lines, and the best cytotoxicity was showed by the
peptide extract against colon cancer cell line LS174.
T2  - Acta Alimentaria
T1  - St. George’s mushroom, Calocybe gambosa (Fr.) Donk: A promising source of nutrients and biologically active compounds
VL  - 51
IS  - 1
SP  - 134
EP  - 144
DO  - 10.1556/066.2021.00227
ER  - 

@article{
author = "Radović, Jelena and Leković, Aleksandra and Damjanović, Ana B. and Kopanja, Đurđica and Dodevska, Margarita and Stanojković, Tatjana and Marinković, Tijana and Jelić, Čedomir and Kundaković-Vasović, Tatjana",
year = "2022",
abstract = "The composition of biologically active compounds of Calocybe gambosa (Lyophyllaceae) was analysed, and
the antioxidant and cytotoxic activities were tested in vitro. C. gambosa was low in energy, fat, and car-
bohydrates, but rich in proteins and fibres. The total polyphenol content in the extracts was low (23.08 ±
0.67 in aqueous and 24.99 ± 4.25 mg GA mg 1 of extract in methanolic extract). The methanolic extract
showed anti-DPPH radical activity with an IC 50 of 626.10 ± 25.20 mg mL 1 . The sample of C. gambosa is
rich in nucleotides and amino acids responsible for its pleasant taste. The nucleoside and 50-mono-
phosphates contents were 0.97 mg g 1 and 2.32 mg g 1 of dry mushroom, respectively. The contents of
essential and non-essential amino acids were 18.41 ± 0.06 and 41.75 ± 0.30 mg g 1 d.w., respectively. The
percentages of saturated and unsaturated fatty acids were 42.6% and 57.4%, respectively. The most
abundant water-soluble and fat-soluble vitamins were B1 and E, respectively. Cytotoxic effect of the extracts was examined against different cancer cell lines, and the best cytotoxicity was showed by the
peptide extract against colon cancer cell line LS174.",
journal = "Acta Alimentaria",
title = "St. George’s mushroom, Calocybe gambosa (Fr.) Donk: A promising source of nutrients and biologically active compounds",
volume = "51",
number = "1",
pages = "134-144",
doi = "10.1556/066.2021.00227"
}

Radović, J., Leković, A., Damjanović, A. B., Kopanja, Đ., Dodevska, M., Stanojković, T., Marinković, T., Jelić, Č.,& Kundaković-Vasović, T.. (2022). St. George’s mushroom, Calocybe gambosa (Fr.) Donk: A promising source of nutrients and biologically active compounds. in Acta Alimentaria, 51(1), 134-144.
https://doi.org/10.1556/066.2021.00227

Radović J, Leković A, Damjanović AB, Kopanja Đ, Dodevska M, Stanojković T, Marinković T, Jelić Č, Kundaković-Vasović T. St. George’s mushroom, Calocybe gambosa (Fr.) Donk: A promising source of nutrients and biologically active compounds. in Acta Alimentaria. 2022;51(1):134-144.
doi:10.1556/066.2021.00227 .

Radović, Jelena, Leković, Aleksandra, Damjanović, Ana B., Kopanja, Đurđica, Dodevska, Margarita, Stanojković, Tatjana, Marinković, Tijana, Jelić, Čedomir, Kundaković-Vasović, Tatjana, "St. George’s mushroom, Calocybe gambosa (Fr.) Donk: A promising source of nutrients and biologically active compounds" in Acta Alimentaria, 51, no. 1 (2022):134-144,
https://doi.org/10.1556/066.2021.00227 . .

TY  - JOUR
AU  - Radović, Jelena
AU  - Leković, Aleksandra
AU  - Tačić, Ana
AU  - Dodevska, Margarita
AU  - Stanojković, Tatjana
AU  - Marinković, Tijana
AU  - Jelić, Čedomir
AU  - Kundaković-Vasović, Tatjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4324
AB  - Nutritional value and chemical composition, including the content of vitamins, fatty acids, 5'-nucleotides and nucleosides and amino acids, as well as biological activities, including antioxidant, angiotensin converting enzyme (ACE) inhibitory and cytotoxic activity of black trumpet (Craterellus cornucopioides (L.) Pers.) were tested in vitro. C. cornucopioides was low in energy, fat and carbohydrate contents, but rich in dietary fibre, especially β-glucan as well as niacin and α-tocopherol. The content of essential and non-essential free amino acids was 1.49 and 5.48 mg/g dry weight (dw). The nucleosides and 5'-nucleotides were determined at 1.84 and 3.99 mg/g dw, respectively. The share of unsaturated fatty acids (UFAs) was 75.92% with oleic acid as the major UFA. Cyclohexane and dichloromethane extracts expressed significant cytotoxic activity against selected cell lines, human epithelial cervical cancer cells (HeLa), adenocarcinomic human alveolar basal epithelial cells (A549), colorectal cancer cells (LS174) and normal MRC-5 human embryonic lung fibroblast cells (IC50 of 78.3-155.6 μg/mL). ACE inhibitory activity of the aqueous extract was strong with an IC50 of 0.74 μg/mL. It can be concluded that black trumpet is a good source of nutrients, such as vitamins, dietary fibres, amino acids, nucleotides and fatty acids, which contribute to the overall nutritional value of this fungus with potential for ACE inhibitory activity and use in anti-hypertensive diet.
PB  - Polish Academy Sciences. Institute of Animal Reproduction and Food Research
T2  - Polish Journal of Food and Nutrition Sciences
T1  - Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity
VL  - 72
IS  - 2
SP  - 171
EP  - 181
DO  - 10.31883/pjfns/149914
ER  - 

@article{
author = "Radović, Jelena and Leković, Aleksandra and Tačić, Ana and Dodevska, Margarita and Stanojković, Tatjana and Marinković, Tijana and Jelić, Čedomir and Kundaković-Vasović, Tatjana",
year = "2022",
abstract = "Nutritional value and chemical composition, including the content of vitamins, fatty acids, 5'-nucleotides and nucleosides and amino acids, as well as biological activities, including antioxidant, angiotensin converting enzyme (ACE) inhibitory and cytotoxic activity of black trumpet (Craterellus cornucopioides (L.) Pers.) were tested in vitro. C. cornucopioides was low in energy, fat and carbohydrate contents, but rich in dietary fibre, especially β-glucan as well as niacin and α-tocopherol. The content of essential and non-essential free amino acids was 1.49 and 5.48 mg/g dry weight (dw). The nucleosides and 5'-nucleotides were determined at 1.84 and 3.99 mg/g dw, respectively. The share of unsaturated fatty acids (UFAs) was 75.92% with oleic acid as the major UFA. Cyclohexane and dichloromethane extracts expressed significant cytotoxic activity against selected cell lines, human epithelial cervical cancer cells (HeLa), adenocarcinomic human alveolar basal epithelial cells (A549), colorectal cancer cells (LS174) and normal MRC-5 human embryonic lung fibroblast cells (IC50 of 78.3-155.6 μg/mL). ACE inhibitory activity of the aqueous extract was strong with an IC50 of 0.74 μg/mL. It can be concluded that black trumpet is a good source of nutrients, such as vitamins, dietary fibres, amino acids, nucleotides and fatty acids, which contribute to the overall nutritional value of this fungus with potential for ACE inhibitory activity and use in anti-hypertensive diet.",
publisher = "Polish Academy Sciences. Institute of Animal Reproduction and Food Research",
journal = "Polish Journal of Food and Nutrition Sciences",
title = "Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity",
volume = "72",
number = "2",
pages = "171-181",
doi = "10.31883/pjfns/149914"
}

Radović, J., Leković, A., Tačić, A., Dodevska, M., Stanojković, T., Marinković, T., Jelić, Č.,& Kundaković-Vasović, T.. (2022). Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity. in Polish Journal of Food and Nutrition Sciences
Polish Academy Sciences. Institute of Animal Reproduction and Food Research., 72(2), 171-181.
https://doi.org/10.31883/pjfns/149914

Radović J, Leković A, Tačić A, Dodevska M, Stanojković T, Marinković T, Jelić Č, Kundaković-Vasović T. Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity. in Polish Journal of Food and Nutrition Sciences. 2022;72(2):171-181.
doi:10.31883/pjfns/149914 .

Radović, Jelena, Leković, Aleksandra, Tačić, Ana, Dodevska, Margarita, Stanojković, Tatjana, Marinković, Tijana, Jelić, Čedomir, Kundaković-Vasović, Tatjana, "Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity" in Polish Journal of Food and Nutrition Sciences, 72, no. 2 (2022):171-181,
https://doi.org/10.31883/pjfns/149914 . .

TY  - JOUR
AU  - Punoševac, Milka
AU  - Radović, Jelena
AU  - Leković, Aleksandra
AU  - Kundaković-Vasović, Tatjana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3919
AB  - Parsley is a biennial aromatic plant from the Apiaceae family, which is characterized by an unbranched root, pinnately divided leaves, umbels and schizocarp. It contains essential oil in all parts, with phenylpropane and terpene compounds as main components. It is rich in flavonoids and other polyphenolic compounds, containing furanocoumarins, carotenoids, polyacetylenes, and its leaves are a source of vitamins and minerals. The chemical composition of parsley depends on a number of factors, so it differs not only in different parts and varieties of the plant, but also in different samples of the same parts of one variety. The most important parsley compounds are myristicin,  apiol,  1-allyl-2,3,4,5-tetramethoxybenzene,  β-phellandrene,  1,3,8-p-menthatriene,                 β-pinene, terpinolene, apiin, oxypeucedanin and falcarinol. Parsley has a long tradition of use in the treatment of urinary tract disorders, and modern in vitro and in vivo studies reveal numerous effects  of  various  parsley  preparations  such  as  diuretic,  antiurolithiasis,  hypouricemic, hypolipidemic,  hypoglycemic,  hypotensive,  antioxidant,  anti-inflammatory  and  antiplatelet effect. Today, apart from its medical application, parsley is one of the most commonly used culinary herbs.
AB  - Peršun je dvogodišnja aromatična biljka iz familije Apiaceae koju karakterišu nerazgranat koren, perasto deljeni listovi, štitaste cvasti i plod šizokarpijum. U svim delovima sadrži etarsko ulje, čije su glavne komponente fenilpropanska i terpenska jedinjenja. Bogat je flavonoidima i drugim polifenolnim jedinjenjima, sadrži furanokumarine, karotenoide, poliacetilene, a listovi su izvor vitamina i minerala. Hemijski sastav peršuna zavisi od brojnih faktora, pa tako postoje razlike u sastavu između ne samo različitih delova i varijeteta biljke, već i različitih uzoraka istih delova jednog varijeteta. Najzastupljenija jedinjenja peršuna su miristicin, apiol, 1-alil-2,3,4,5tetrametoksibenzen, b-felandren, 1,3,8-p-mentatrien, b-pinen, terpinolen, apiin, oksipeucedanin i falkarinol. Peršun ima dugu tradiciju upotrebe u tretmanu poremećaja funkcije urinarnog trakta, a savremena in vitro i in vivo ispitivanja otkrivaju i brojne efekte koje poseduju različiti preparati peršuna kao što su diuretički, antiurolitijazni, hipourikemijski, hipolipidemijski, hipoglikemijski, hipotenzivni, antioksidativni, antiinflamatorni, antimikrobni i antiagregacioni. Danas, pored medicinske primene, peršun je jedna od najkorišćenijih začinskih biljaka.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - A review of botanical characteristics, chemical composition, pharmacological activity and use of parsley
T1  - Pregled botaničkih karakteristika, hemijskog sastava, farmakološke aktivnosti i primene peršuna
VL  - 71
IS  - 3
SP  - 177
EP  - 196
DO  - 10.5937/arhfarm71‐30800
ER  - 

@article{
author = "Punoševac, Milka and Radović, Jelena and Leković, Aleksandra and Kundaković-Vasović, Tatjana",
year = "2021",
abstract = "Parsley is a biennial aromatic plant from the Apiaceae family, which is characterized by an unbranched root, pinnately divided leaves, umbels and schizocarp. It contains essential oil in all parts, with phenylpropane and terpene compounds as main components. It is rich in flavonoids and other polyphenolic compounds, containing furanocoumarins, carotenoids, polyacetylenes, and its leaves are a source of vitamins and minerals. The chemical composition of parsley depends on a number of factors, so it differs not only in different parts and varieties of the plant, but also in different samples of the same parts of one variety. The most important parsley compounds are myristicin,  apiol,  1-allyl-2,3,4,5-tetramethoxybenzene,  β-phellandrene,  1,3,8-p-menthatriene,                 β-pinene, terpinolene, apiin, oxypeucedanin and falcarinol. Parsley has a long tradition of use in the treatment of urinary tract disorders, and modern in vitro and in vivo studies reveal numerous effects  of  various  parsley  preparations  such  as  diuretic,  antiurolithiasis,  hypouricemic, hypolipidemic,  hypoglycemic,  hypotensive,  antioxidant,  anti-inflammatory  and  antiplatelet effect. Today, apart from its medical application, parsley is one of the most commonly used culinary herbs., Peršun je dvogodišnja aromatična biljka iz familije Apiaceae koju karakterišu nerazgranat koren, perasto deljeni listovi, štitaste cvasti i plod šizokarpijum. U svim delovima sadrži etarsko ulje, čije su glavne komponente fenilpropanska i terpenska jedinjenja. Bogat je flavonoidima i drugim polifenolnim jedinjenjima, sadrži furanokumarine, karotenoide, poliacetilene, a listovi su izvor vitamina i minerala. Hemijski sastav peršuna zavisi od brojnih faktora, pa tako postoje razlike u sastavu između ne samo različitih delova i varijeteta biljke, već i različitih uzoraka istih delova jednog varijeteta. Najzastupljenija jedinjenja peršuna su miristicin, apiol, 1-alil-2,3,4,5tetrametoksibenzen, b-felandren, 1,3,8-p-mentatrien, b-pinen, terpinolen, apiin, oksipeucedanin i falkarinol. Peršun ima dugu tradiciju upotrebe u tretmanu poremećaja funkcije urinarnog trakta, a savremena in vitro i in vivo ispitivanja otkrivaju i brojne efekte koje poseduju različiti preparati peršuna kao što su diuretički, antiurolitijazni, hipourikemijski, hipolipidemijski, hipoglikemijski, hipotenzivni, antioksidativni, antiinflamatorni, antimikrobni i antiagregacioni. Danas, pored medicinske primene, peršun je jedna od najkorišćenijih začinskih biljaka.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "A review of botanical characteristics, chemical composition, pharmacological activity and use of parsley, Pregled botaničkih karakteristika, hemijskog sastava, farmakološke aktivnosti i primene peršuna",
volume = "71",
number = "3",
pages = "177-196",
doi = "10.5937/arhfarm71‐30800"
}

Punoševac, M., Radović, J., Leković, A.,& Kundaković-Vasović, T.. (2021). A review of botanical characteristics, chemical composition, pharmacological activity and use of parsley. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 71(3), 177-196.
https://doi.org/10.5937/arhfarm71‐30800

Punoševac M, Radović J, Leković A, Kundaković-Vasović T. A review of botanical characteristics, chemical composition, pharmacological activity and use of parsley. in Arhiv za farmaciju. 2021;71(3):177-196.
doi:10.5937/arhfarm71‐30800 .

Punoševac, Milka, Radović, Jelena, Leković, Aleksandra, Kundaković-Vasović, Tatjana, "A review of botanical characteristics, chemical composition, pharmacological activity and use of parsley" in Arhiv za farmaciju, 71, no. 3 (2021):177-196,
https://doi.org/10.5937/arhfarm71‐30800 . .