TY  - JOUR
AU  - Stojanović, Stefan
AU  - Nićiforović, Jovan
AU  - Živanović, Sandra
AU  - Odović, Jadranka
AU  - Jelić, Ratomir
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3614
AB  - bstract: Concomitant use of two or more drugs in therapy is becoming a more frequent phenomenon and clinically relevant drug–drug interactions at the level of binding to human serum albumin (HSA) are more often. The influence of fluoroquinolones–sparfloxacin, levofloxacin, and ciprofloxacin, on the interaction between tigecycline and HSA, was investigated in vitro by means of fluorescence and absorption spectroscopy. The results of UV–Vis and fluorescence spectroscopy showed that the fluorescence quenching of HSA was a result of the formation of new complexes through a static quenching process. The binding constants (Ka) and the number of binding sites (n) of all systems were calculated. The presence of sparfloxacin and ciprofloxacin increases and that of levofloxacin slightly decreases the binding constant of the HSA–tigecycline system. Competitive binding studies in the presence of site-specific markers showed that tigecycline was not significantly displaced by ibuprofen, but warfarin showed a significant displacement of tigecycline. These results suggest that the competitive binding of tigecycline and warfarin to HSA exists. The results confirm that the binding site of tigecycline is mainly located in Sudlow’s site I (subdomain IIA) of HSA. Graphic abstract: [Figure not available: see fulltext.
PB  - Springer
T2  - Monatshefte fur Chemie
T1  - Spectroscopic studies on the drug–drug interaction: the influence of fluoroquinolones on the affinity of tigecycline to human serum albumin and identification of the binding site
VL  - 151
SP  - 999
EP  - 1007
DO  - 10.1007/s00706-020-02627-0
ER  - 

@article{
author = "Stojanović, Stefan and Nićiforović, Jovan and Živanović, Sandra and Odović, Jadranka and Jelić, Ratomir",
year = "2020",
abstract = "bstract: Concomitant use of two or more drugs in therapy is becoming a more frequent phenomenon and clinically relevant drug–drug interactions at the level of binding to human serum albumin (HSA) are more often. The influence of fluoroquinolones–sparfloxacin, levofloxacin, and ciprofloxacin, on the interaction between tigecycline and HSA, was investigated in vitro by means of fluorescence and absorption spectroscopy. The results of UV–Vis and fluorescence spectroscopy showed that the fluorescence quenching of HSA was a result of the formation of new complexes through a static quenching process. The binding constants (Ka) and the number of binding sites (n) of all systems were calculated. The presence of sparfloxacin and ciprofloxacin increases and that of levofloxacin slightly decreases the binding constant of the HSA–tigecycline system. Competitive binding studies in the presence of site-specific markers showed that tigecycline was not significantly displaced by ibuprofen, but warfarin showed a significant displacement of tigecycline. These results suggest that the competitive binding of tigecycline and warfarin to HSA exists. The results confirm that the binding site of tigecycline is mainly located in Sudlow’s site I (subdomain IIA) of HSA. Graphic abstract: [Figure not available: see fulltext.",
publisher = "Springer",
journal = "Monatshefte fur Chemie",
title = "Spectroscopic studies on the drug–drug interaction: the influence of fluoroquinolones on the affinity of tigecycline to human serum albumin and identification of the binding site",
volume = "151",
pages = "999-1007",
doi = "10.1007/s00706-020-02627-0"
}

Stojanović, S., Nićiforović, J., Živanović, S., Odović, J.,& Jelić, R.. (2020). Spectroscopic studies on the drug–drug interaction: the influence of fluoroquinolones on the affinity of tigecycline to human serum albumin and identification of the binding site. in Monatshefte fur Chemie
Springer., 151, 999-1007.
https://doi.org/10.1007/s00706-020-02627-0

Stojanović S, Nićiforović J, Živanović S, Odović J, Jelić R. Spectroscopic studies on the drug–drug interaction: the influence of fluoroquinolones on the affinity of tigecycline to human serum albumin and identification of the binding site. in Monatshefte fur Chemie. 2020;151:999-1007.
doi:10.1007/s00706-020-02627-0 .

Stojanović, Stefan, Nićiforović, Jovan, Živanović, Sandra, Odović, Jadranka, Jelić, Ratomir, "Spectroscopic studies on the drug–drug interaction: the influence of fluoroquinolones on the affinity of tigecycline to human serum albumin and identification of the binding site" in Monatshefte fur Chemie, 151 (2020):999-1007,
https://doi.org/10.1007/s00706-020-02627-0 . .

TY  - JOUR
AU  - Jelić, Ratomir
AU  - Stojanović, Stefan D.
AU  - Berić, Jelena D.
AU  - Odović, Jadranka
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3031
AB  - The co-administration of several drugs in multidrug therapy may alter the binding of each drug to human serum albumin (HSA) and, thus, their pharmacology effect. Therefore, in this study, the interaction mechanism between HSA and two fluoroquinolones (FQs), sparfloxacin (SPF) and levofloxacin (LVF), was investigated using fluorescence and absorption methods in the absence and presence of the competing drugtigecycline (TGC). The UV-Vis and fluorescence spectroscopy results showed that the fluorescence quenching of HSA was a result of the formation of the HSA-SPF and HSA-LVF complexes. The fluorescence quenching of HSA-TGC revealed that tigecycline can regulate the binding sites, binding mode and binding affinity of fl uoroquinolones. The binding constants (KA) and binding sites (n) of the interaction systems were calculated. The results confirmed that the KA values of the HSA-FQ system decreased in the presence of TGC, indicating that TGC can affect the binding ability of FQ for HSA. This interaction may increase the free plasma concentration of unbound FQ and enhance their pharmacology effect.
AB  - Istovremena primena nekoliko lekova, u multilek terapiji, može izmeniti njihovo vezivanje za humani serumski albumin (HSA) i njihov farmakološki efekat. Zbog toga, u ovom radu je proučavan mehanizam interakcije između HSA i dva fluorohinolona (FQs): sparfloksacina (SPF) i levofloksacina (LVF) fluorescentnim i apsorpcionim metodama u odsustvu i prisustvu konkurentskog leka - tigeciklina (TGC). Rezultati UV-Vis i fluorescentne spektroskopije su pokazali da je gašenje fluorescencije u HSA rezultat formiranja HSA-SPF i HSA-LVF kompleksa. Gašenje fluoroscencije u HSA-TGC je pokazalo da tigeciklin može regulisati mesta vezivanja, način vezivanja i afinitet vezivanja fluorohinolona. Konstante vezivanja (KA) i broj vezujućih mesta (n) za interakcije u sistemu su izračunate. Rezultati su potvrdili da su vrednosti KA u HSA-FQ sistemu, smanjene u prisustvu TGC, a to ukazuje da TGC može da utiče na sposobnost vezivanja FQ za HSA. Ova interakcija može povećati slobodnu koncentraciju u plazmi nevezanog FQ i poboljšati njegov farmakološki efekat.
PB  - Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac
T2  - Serbian Journal of Experimental and Clinical Research
T1  - The effect of tigecycline on the binding of fluoroquinolones to human serum albumin
T1  - Dejstvo tigeciklina na vezivanje fluorohinolona za humani serumski albumin
VL  - 19
IS  - 1
SP  - 17
EP  - 25
DO  - 10.1515/SJECR-2017-0006
ER  - 

@article{
author = "Jelić, Ratomir and Stojanović, Stefan D. and Berić, Jelena D. and Odović, Jadranka",
year = "2018",
abstract = "The co-administration of several drugs in multidrug therapy may alter the binding of each drug to human serum albumin (HSA) and, thus, their pharmacology effect. Therefore, in this study, the interaction mechanism between HSA and two fluoroquinolones (FQs), sparfloxacin (SPF) and levofloxacin (LVF), was investigated using fluorescence and absorption methods in the absence and presence of the competing drugtigecycline (TGC). The UV-Vis and fluorescence spectroscopy results showed that the fluorescence quenching of HSA was a result of the formation of the HSA-SPF and HSA-LVF complexes. The fluorescence quenching of HSA-TGC revealed that tigecycline can regulate the binding sites, binding mode and binding affinity of fl uoroquinolones. The binding constants (KA) and binding sites (n) of the interaction systems were calculated. The results confirmed that the KA values of the HSA-FQ system decreased in the presence of TGC, indicating that TGC can affect the binding ability of FQ for HSA. This interaction may increase the free plasma concentration of unbound FQ and enhance their pharmacology effect., Istovremena primena nekoliko lekova, u multilek terapiji, može izmeniti njihovo vezivanje za humani serumski albumin (HSA) i njihov farmakološki efekat. Zbog toga, u ovom radu je proučavan mehanizam interakcije između HSA i dva fluorohinolona (FQs): sparfloksacina (SPF) i levofloksacina (LVF) fluorescentnim i apsorpcionim metodama u odsustvu i prisustvu konkurentskog leka - tigeciklina (TGC). Rezultati UV-Vis i fluorescentne spektroskopije su pokazali da je gašenje fluorescencije u HSA rezultat formiranja HSA-SPF i HSA-LVF kompleksa. Gašenje fluoroscencije u HSA-TGC je pokazalo da tigeciklin može regulisati mesta vezivanja, način vezivanja i afinitet vezivanja fluorohinolona. Konstante vezivanja (KA) i broj vezujućih mesta (n) za interakcije u sistemu su izračunate. Rezultati su potvrdili da su vrednosti KA u HSA-FQ sistemu, smanjene u prisustvu TGC, a to ukazuje da TGC može da utiče na sposobnost vezivanja FQ za HSA. Ova interakcija može povećati slobodnu koncentraciju u plazmi nevezanog FQ i poboljšati njegov farmakološki efekat.",
publisher = "Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac",
journal = "Serbian Journal of Experimental and Clinical Research",
title = "The effect of tigecycline on the binding of fluoroquinolones to human serum albumin, Dejstvo tigeciklina na vezivanje fluorohinolona za humani serumski albumin",
volume = "19",
number = "1",
pages = "17-25",
doi = "10.1515/SJECR-2017-0006"
}

Jelić, R., Stojanović, S. D., Berić, J. D.,& Odović, J.. (2018). The effect of tigecycline on the binding of fluoroquinolones to human serum albumin. in Serbian Journal of Experimental and Clinical Research
Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac., 19(1), 17-25.
https://doi.org/10.1515/SJECR-2017-0006

Jelić R, Stojanović SD, Berić JD, Odović J. The effect of tigecycline on the binding of fluoroquinolones to human serum albumin. in Serbian Journal of Experimental and Clinical Research. 2018;19(1):17-25.
doi:10.1515/SJECR-2017-0006 .

Jelić, Ratomir, Stojanović, Stefan D., Berić, Jelena D., Odović, Jadranka, "The effect of tigecycline on the binding of fluoroquinolones to human serum albumin" in Serbian Journal of Experimental and Clinical Research, 19, no. 1 (2018):17-25,
https://doi.org/10.1515/SJECR-2017-0006 . .

TY  - JOUR
AU  - Trbojević, Jovana
AU  - Odović, Jadranka
AU  - Trbojević-Stanković, Jasna
AU  - Stojimirović, Biljana
AU  - Jelić, Ratomir
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2781
AB  - Angiotensin-converting enzyme (ACE) inhibitors modulate the function of the renin-angiotensin-aldosterone system, and they are commonly prescribed antihypertensive drugs especially in patients with renal failure. In this study, the relationships between several molecular properties of eight ACE inhibitors (enalapril, quinapril, fosinopril, ramipril, benazepril, perindopril, moexipril, trandolapril) and their renal elimination data, from relevant literature, were investigated. The 'molecular descriptors of the ACE inhibitors, which included aqueous solubility data (logS); an electronic descriptor, polar surface area (PSA);, a constitutional parameter, molecular mass (Mr); and a geometric descriptor, volume value (Vol), as well as lipophilicity descriptors (logP values), were calculated using different software packages. Simple linear regression analysis showed the best correlation between renal elimination data and lipophilicity descriptor AClogP values (R2 = 0.5742). In the next stage of the study, multiple linear regression was applied to assess a higher correlation between the ACE inhibitors' renal elimination data and lipophilicity, AClogP, with one additional descriptor as an independent variable. Good correlations were established between renal elimination data from the literature and the AClogP lipophilicity descriptor using the constitutional parameter (molecular mass (R2 = 0.7425)) or the geometric descriptor (volume value (R2 = 0.7224)) as an independent variable. the application of computed molecular descriptors in evaluating drug elimination is of great importance in drug research.
AB  - Inhibitori enzima koji konvertuje angiotenzin (ACE) modifikuju funkciju renin-angiotenzin-aldosteron sistema i predstavljaju često propisane lekova za sniženje pritiska, posebno kod pacijenata sa insuficijencijom bubrega. U ovom radu, za osam odabranih ACE inhibitora (enalapril, kvinapril, fosinopril, ramipril, benazepril, perindopril, moeksipril, trandolapril) ispitan je odnos između osobina njihovih molekula i njihove eliminacije putem bubrega. Za ispitivane inhibitore ACE korišć enjem različitih softverskih paketa izračunate su vrednosti nekoliko molekulskih deskriptora: rastvorljivost u vodi (logS), elektronski deskriptor - polarna površina molekula (PSA), molekulska masa (Mw), geometrijski deskriptor - volumen molekula (Vol) kao i deskriptor lipofilnosti (logP vrednosti). Primenom proste linearne regresione analize najbolja zavisnost dobijena je između podataka o eliminaciji inhibitora ACE putem bubrega i deskriptora lipofilnosti, AClogP vrednosti (R2 = 0.5742). U sledećoj fazi istraživanja primenjena je metoda višestruke regresione analize (MLR) kako bi se dobila bolja zavisnost između podataka o eliminaciji ACE inhibitora putem bubrega i njihove lipofilnosti (AClogP vrednosti) uz primenu dodatnog molekulskog deskriptora kao nezavisno promenljive. Dobre korelacije su dobijene između podataka o eliminaciji putem bubrega i deskriptora lipofilnosti AClogP, uz primenu molekulske mase (R2 = 0.7425) ili zapremine molekula (R2 = 0.7224) kao nezavisno promenljive. Mogućnost primene izračunatih molekulskih deskriptora u proceni eliminacije lekova je od velikog značaja u njihovom istraživanju.
PB  - Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac
T2  - Serbian Journal of Experimental and Clinical Research
T1  - The evaluation of angiotensin-converting enzyme inhibitors in renal elimination with selected molecular descriptors
T1  - Procena renalne eliminacije inhibitora enzima koji konvertuje angiotensin sa odabranim molekulskim deskriptorima
VL  - 18
IS  - 2
SP  - 119
EP  - 123
DO  - 10.1515/SJECR-2016-0100
ER  - 

@article{
author = "Trbojević, Jovana and Odović, Jadranka and Trbojević-Stanković, Jasna and Stojimirović, Biljana and Jelić, Ratomir",
year = "2017",
abstract = "Angiotensin-converting enzyme (ACE) inhibitors modulate the function of the renin-angiotensin-aldosterone system, and they are commonly prescribed antihypertensive drugs especially in patients with renal failure. In this study, the relationships between several molecular properties of eight ACE inhibitors (enalapril, quinapril, fosinopril, ramipril, benazepril, perindopril, moexipril, trandolapril) and their renal elimination data, from relevant literature, were investigated. The 'molecular descriptors of the ACE inhibitors, which included aqueous solubility data (logS); an electronic descriptor, polar surface area (PSA);, a constitutional parameter, molecular mass (Mr); and a geometric descriptor, volume value (Vol), as well as lipophilicity descriptors (logP values), were calculated using different software packages. Simple linear regression analysis showed the best correlation between renal elimination data and lipophilicity descriptor AClogP values (R2 = 0.5742). In the next stage of the study, multiple linear regression was applied to assess a higher correlation between the ACE inhibitors' renal elimination data and lipophilicity, AClogP, with one additional descriptor as an independent variable. Good correlations were established between renal elimination data from the literature and the AClogP lipophilicity descriptor using the constitutional parameter (molecular mass (R2 = 0.7425)) or the geometric descriptor (volume value (R2 = 0.7224)) as an independent variable. the application of computed molecular descriptors in evaluating drug elimination is of great importance in drug research., Inhibitori enzima koji konvertuje angiotenzin (ACE) modifikuju funkciju renin-angiotenzin-aldosteron sistema i predstavljaju često propisane lekova za sniženje pritiska, posebno kod pacijenata sa insuficijencijom bubrega. U ovom radu, za osam odabranih ACE inhibitora (enalapril, kvinapril, fosinopril, ramipril, benazepril, perindopril, moeksipril, trandolapril) ispitan je odnos između osobina njihovih molekula i njihove eliminacije putem bubrega. Za ispitivane inhibitore ACE korišć enjem različitih softverskih paketa izračunate su vrednosti nekoliko molekulskih deskriptora: rastvorljivost u vodi (logS), elektronski deskriptor - polarna površina molekula (PSA), molekulska masa (Mw), geometrijski deskriptor - volumen molekula (Vol) kao i deskriptor lipofilnosti (logP vrednosti). Primenom proste linearne regresione analize najbolja zavisnost dobijena je između podataka o eliminaciji inhibitora ACE putem bubrega i deskriptora lipofilnosti, AClogP vrednosti (R2 = 0.5742). U sledećoj fazi istraživanja primenjena je metoda višestruke regresione analize (MLR) kako bi se dobila bolja zavisnost između podataka o eliminaciji ACE inhibitora putem bubrega i njihove lipofilnosti (AClogP vrednosti) uz primenu dodatnog molekulskog deskriptora kao nezavisno promenljive. Dobre korelacije su dobijene između podataka o eliminaciji putem bubrega i deskriptora lipofilnosti AClogP, uz primenu molekulske mase (R2 = 0.7425) ili zapremine molekula (R2 = 0.7224) kao nezavisno promenljive. Mogućnost primene izračunatih molekulskih deskriptora u proceni eliminacije lekova je od velikog značaja u njihovom istraživanju.",
publisher = "Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac",
journal = "Serbian Journal of Experimental and Clinical Research",
title = "The evaluation of angiotensin-converting enzyme inhibitors in renal elimination with selected molecular descriptors, Procena renalne eliminacije inhibitora enzima koji konvertuje angiotensin sa odabranim molekulskim deskriptorima",
volume = "18",
number = "2",
pages = "119-123",
doi = "10.1515/SJECR-2016-0100"
}

Trbojević, J., Odović, J., Trbojević-Stanković, J., Stojimirović, B.,& Jelić, R.. (2017). The evaluation of angiotensin-converting enzyme inhibitors in renal elimination with selected molecular descriptors. in Serbian Journal of Experimental and Clinical Research
Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac., 18(2), 119-123.
https://doi.org/10.1515/SJECR-2016-0100

Trbojević J, Odović J, Trbojević-Stanković J, Stojimirović B, Jelić R. The evaluation of angiotensin-converting enzyme inhibitors in renal elimination with selected molecular descriptors. in Serbian Journal of Experimental and Clinical Research. 2017;18(2):119-123.
doi:10.1515/SJECR-2016-0100 .

Trbojević, Jovana, Odović, Jadranka, Trbojević-Stanković, Jasna, Stojimirović, Biljana, Jelić, Ratomir, "The evaluation of angiotensin-converting enzyme inhibitors in renal elimination with selected molecular descriptors" in Serbian Journal of Experimental and Clinical Research, 18, no. 2 (2017):119-123,
https://doi.org/10.1515/SJECR-2016-0100 . .

TY  - JOUR
AU  - Berić, Jelena D.
AU  - Jelić, Ratomir
AU  - Nešić, Dejan M.
AU  - Trbojević-Stanković, Jasna
AU  - Odović, Jadranka
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2794
AB  - The plasma protein binding (PPB) data of twelve antipsychotics (aripiprazole, clozapine, olanzapine, quetiapine, risperidone, sertindole, ziprasidone, chlorpromazine, flupentixol, fluphenazine, haloperidol, zuclopenthixol) were estimated using computed molecular descriptors, which included the electronic descriptor - polar surface area (PSA), the constitutional parameter - molecular weight (Mw), the geometric descriptor - volume value (Vol), the lipophilicity descriptor (logP) and aqueous solubility data (logS), and the acidity descriptor (pK(a)). The relationships between computed molecular properties of the selected antipsychotics and their PPB data were investigated by simple linear regression analysis. Low correlations were obtained between the PPB data of the antipsychotics and PSA, Mw, Vol, pKa, logS (R  lt  0.30) values, while relatively higher correlations (0.35 lt R-2 lt 0.70) were obtained for the majority of logP values. Multiple linear regression (MLR) analysis was applied to access reliable correlations of the PPB data of the antipsychotics and the computed molecular descriptors. Relationships with acceptable probability values (P lt 0.05) were established for five lipophilicity descriptors (logP values) with application of the acidity descriptor (pKa) as independent variables: AlogP (R-2=0.705), XlogP3 (R-2=0.679), ClogP (R-2=0.590), XlogP2 (R-2=0.567), as well as for the experimental lipophilicity parameter, logPexp (R-2=0.635). The best correlations obtained in MLR using AlogP and pKa as independent variables were checked using three additional antipsychotics: loxapine, sulpiride and amisulpride, with the PPB values of 97%, "less than" 40% and 17%, respectively. Their predicted PPB values were relatively close to the literature data. The proposed technique confirmed that lipophilicity, together with acidity significantly influences the PPB of antipsychotics. The described procedure can be regarded as an additional in vitro approach to the modeling of the investigated group of drugs.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Estimation of plasma protein binding of selected antipsychotics using computed molecular properties
VL  - 69
IS  - 3
SP  - 463
EP  - 468
DO  - 10.2298/ABS160912121B
ER  - 

@article{
author = "Berić, Jelena D. and Jelić, Ratomir and Nešić, Dejan M. and Trbojević-Stanković, Jasna and Odović, Jadranka",
year = "2017",
abstract = "The plasma protein binding (PPB) data of twelve antipsychotics (aripiprazole, clozapine, olanzapine, quetiapine, risperidone, sertindole, ziprasidone, chlorpromazine, flupentixol, fluphenazine, haloperidol, zuclopenthixol) were estimated using computed molecular descriptors, which included the electronic descriptor - polar surface area (PSA), the constitutional parameter - molecular weight (Mw), the geometric descriptor - volume value (Vol), the lipophilicity descriptor (logP) and aqueous solubility data (logS), and the acidity descriptor (pK(a)). The relationships between computed molecular properties of the selected antipsychotics and their PPB data were investigated by simple linear regression analysis. Low correlations were obtained between the PPB data of the antipsychotics and PSA, Mw, Vol, pKa, logS (R  lt  0.30) values, while relatively higher correlations (0.35 lt R-2 lt 0.70) were obtained for the majority of logP values. Multiple linear regression (MLR) analysis was applied to access reliable correlations of the PPB data of the antipsychotics and the computed molecular descriptors. Relationships with acceptable probability values (P lt 0.05) were established for five lipophilicity descriptors (logP values) with application of the acidity descriptor (pKa) as independent variables: AlogP (R-2=0.705), XlogP3 (R-2=0.679), ClogP (R-2=0.590), XlogP2 (R-2=0.567), as well as for the experimental lipophilicity parameter, logPexp (R-2=0.635). The best correlations obtained in MLR using AlogP and pKa as independent variables were checked using three additional antipsychotics: loxapine, sulpiride and amisulpride, with the PPB values of 97%, "less than" 40% and 17%, respectively. Their predicted PPB values were relatively close to the literature data. The proposed technique confirmed that lipophilicity, together with acidity significantly influences the PPB of antipsychotics. The described procedure can be regarded as an additional in vitro approach to the modeling of the investigated group of drugs.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Estimation of plasma protein binding of selected antipsychotics using computed molecular properties",
volume = "69",
number = "3",
pages = "463-468",
doi = "10.2298/ABS160912121B"
}

Berić, J. D., Jelić, R., Nešić, D. M., Trbojević-Stanković, J.,& Odović, J.. (2017). Estimation of plasma protein binding of selected antipsychotics using computed molecular properties. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 69(3), 463-468.
https://doi.org/10.2298/ABS160912121B

Berić JD, Jelić R, Nešić DM, Trbojević-Stanković J, Odović J. Estimation of plasma protein binding of selected antipsychotics using computed molecular properties. in Archives of Biological Sciences. 2017;69(3):463-468.
doi:10.2298/ABS160912121B .

Berić, Jelena D., Jelić, Ratomir, Nešić, Dejan M., Trbojević-Stanković, Jasna, Odović, Jadranka, "Estimation of plasma protein binding of selected antipsychotics using computed molecular properties" in Archives of Biological Sciences, 69, no. 3 (2017):463-468,
https://doi.org/10.2298/ABS160912121B . .

TY  - JOUR
AU  - Odović, Jadranka
AU  - Trbojević, Jovana B.
AU  - Trbojević-Stanković, Jasna
AU  - Nešić, Dejan M.
AU  - Jelić, Ratomir
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2904
AB  - In this study we investigated the relationship between the calcium channel blockers (CCBs), amlodipine, felodipine, isradipine, nicardipine, nifedipine, nimodipine, nisoldipine, verapamil and diltiazem, and their calculated molecular descriptors: polar surface area (PSA), molecular weight (Mw), volume value (Vol), aqueous solubility data (logS), lipophilicity (logP), acidity (pKa values) and plasma protein binding (PPB) data, obtained from relevant literature. The relationships between the computed molecular properties of selected CCBs and their PPB data were investigated by simple linear regression analysis that revealed very low correlations (R2 lt 0.35). When multiple linear regression (MLR) analysis was applied to investigate reliable correlations between the CCBs' calculated molecular descriptors and PPB data, the best correlations were found for the relationships between CCBs, and PPB data and lipophilicity, and with application of the molecular descriptor (Mw, Vol, or pKa) data as additional independent variables (R2=0.623; R2=0.741; R2=0.657, respectively), with an acceptable probability value (P lt 0.05), confirming that lipophilicity, together with other molecular properties, are essential for the drugs' PPB. We conclude that this could be considered as an additional in vitro approach for modeling CCBs.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Assessment of the relationship between the molecular properties of calcium channel blockers and plasma protein binding data
VL  - 69
IS  - 1
SP  - 175
EP  - 179
DO  - 10.2298/ABS160609094O
ER  - 

@article{
author = "Odović, Jadranka and Trbojević, Jovana B. and Trbojević-Stanković, Jasna and Nešić, Dejan M. and Jelić, Ratomir",
year = "2017",
abstract = "In this study we investigated the relationship between the calcium channel blockers (CCBs), amlodipine, felodipine, isradipine, nicardipine, nifedipine, nimodipine, nisoldipine, verapamil and diltiazem, and their calculated molecular descriptors: polar surface area (PSA), molecular weight (Mw), volume value (Vol), aqueous solubility data (logS), lipophilicity (logP), acidity (pKa values) and plasma protein binding (PPB) data, obtained from relevant literature. The relationships between the computed molecular properties of selected CCBs and their PPB data were investigated by simple linear regression analysis that revealed very low correlations (R2 lt 0.35). When multiple linear regression (MLR) analysis was applied to investigate reliable correlations between the CCBs' calculated molecular descriptors and PPB data, the best correlations were found for the relationships between CCBs, and PPB data and lipophilicity, and with application of the molecular descriptor (Mw, Vol, or pKa) data as additional independent variables (R2=0.623; R2=0.741; R2=0.657, respectively), with an acceptable probability value (P lt 0.05), confirming that lipophilicity, together with other molecular properties, are essential for the drugs' PPB. We conclude that this could be considered as an additional in vitro approach for modeling CCBs.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Assessment of the relationship between the molecular properties of calcium channel blockers and plasma protein binding data",
volume = "69",
number = "1",
pages = "175-179",
doi = "10.2298/ABS160609094O"
}

Odović, J., Trbojević, J. B., Trbojević-Stanković, J., Nešić, D. M.,& Jelić, R.. (2017). Assessment of the relationship between the molecular properties of calcium channel blockers and plasma protein binding data. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 69(1), 175-179.
https://doi.org/10.2298/ABS160609094O

Odović J, Trbojević JB, Trbojević-Stanković J, Nešić DM, Jelić R. Assessment of the relationship between the molecular properties of calcium channel blockers and plasma protein binding data. in Archives of Biological Sciences. 2017;69(1):175-179.
doi:10.2298/ABS160609094O .

Odović, Jadranka, Trbojević, Jovana B., Trbojević-Stanković, Jasna, Nešić, Dejan M., Jelić, Ratomir, "Assessment of the relationship between the molecular properties of calcium channel blockers and plasma protein binding data" in Archives of Biological Sciences, 69, no. 1 (2017):175-179,
https://doi.org/10.2298/ABS160609094O . .

TY  - JOUR
AU  - Trbojević, Jovana B.
AU  - Odović, Jadranka
AU  - Trbojević-Stanković, Jasna
AU  - Nešić, Dejan M.
AU  - Jelić, Ratomir
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2536
AB  - In the present study, we investigated the relationships between several molecular properties and bioavailability data for seven of the most commonly prescribed angiotensin II receptor antagonists (also known as angiotensin II receptor blockers (ARBs) or sartans), candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan and valsartan. The molecular descriptors of ARBs are:, aqueous solubility (logS values), polar surface area (PSA), molecular weight (Mw), volume value (Vol), lipophilicity (logP values) and the acidity descriptor (pK(a1)). The respective descriptors were calculated using four different software packages. The relevant bioavailability data were obtained from literature. Among calculated molecular descriptors, simple linear regression analysis showed the best correlation between bioavailability data and the lipophilicity descriptor, logP (R-2 = 0.568). Multiple linear regression established good correlations between bioavailability and the lipophilicity descriptor, logP, using the molecular weight, Mw, or the acidity descriptor, pK(a1), as an additional, independent variable (with R-2 = 0.661 and 0.682, respectively). Finally, excluding candesartan from the calculations resulted in a very good correlation (R-2 = 0.852) between the remaining ARB bioavailability and molecular descriptors MlogP and Mw as independent variables, determined by multiple linear regression.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Relationship between the bioavailability and molecular properties of angiotensin II receptor antagonists
VL  - 68
IS  - 2
SP  - 273
EP  - 278
DO  - 10.2298/ABS150915015T
ER  - 

@article{
author = "Trbojević, Jovana B. and Odović, Jadranka and Trbojević-Stanković, Jasna and Nešić, Dejan M. and Jelić, Ratomir",
year = "2016",
abstract = "In the present study, we investigated the relationships between several molecular properties and bioavailability data for seven of the most commonly prescribed angiotensin II receptor antagonists (also known as angiotensin II receptor blockers (ARBs) or sartans), candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan and valsartan. The molecular descriptors of ARBs are:, aqueous solubility (logS values), polar surface area (PSA), molecular weight (Mw), volume value (Vol), lipophilicity (logP values) and the acidity descriptor (pK(a1)). The respective descriptors were calculated using four different software packages. The relevant bioavailability data were obtained from literature. Among calculated molecular descriptors, simple linear regression analysis showed the best correlation between bioavailability data and the lipophilicity descriptor, logP (R-2 = 0.568). Multiple linear regression established good correlations between bioavailability and the lipophilicity descriptor, logP, using the molecular weight, Mw, or the acidity descriptor, pK(a1), as an additional, independent variable (with R-2 = 0.661 and 0.682, respectively). Finally, excluding candesartan from the calculations resulted in a very good correlation (R-2 = 0.852) between the remaining ARB bioavailability and molecular descriptors MlogP and Mw as independent variables, determined by multiple linear regression.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Relationship between the bioavailability and molecular properties of angiotensin II receptor antagonists",
volume = "68",
number = "2",
pages = "273-278",
doi = "10.2298/ABS150915015T"
}

Trbojević, J. B., Odović, J., Trbojević-Stanković, J., Nešić, D. M.,& Jelić, R.. (2016). Relationship between the bioavailability and molecular properties of angiotensin II receptor antagonists. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 68(2), 273-278.
https://doi.org/10.2298/ABS150915015T

Trbojević JB, Odović J, Trbojević-Stanković J, Nešić DM, Jelić R. Relationship between the bioavailability and molecular properties of angiotensin II receptor antagonists. in Archives of Biological Sciences. 2016;68(2):273-278.
doi:10.2298/ABS150915015T .

Trbojević, Jovana B., Odović, Jadranka, Trbojević-Stanković, Jasna, Nešić, Dejan M., Jelić, Ratomir, "Relationship between the bioavailability and molecular properties of angiotensin II receptor antagonists" in Archives of Biological Sciences, 68, no. 2 (2016):273-278,
https://doi.org/10.2298/ABS150915015T . .

TY  - JOUR
AU  - Trbojević-Stanković, Jasna
AU  - Odović, Jadranka
AU  - Jelić, Ratomir
AU  - Nešić, Dejan M.
AU  - Stojimirović, Biljana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2356
AB  - Calcium channel blockers (CCBs) are among the most widely used drugs in cardiovascular medicine. In this study, nine CCBs (amlodipine, felodipine, isradipine, nicardipine, nifedipine, nimodipine, nisoldipine, verapamil and diltiazem) were investigated to assess the relationship between their molecular properties and elimination data obtained from literature. The descriptors of the molecular properties of CCBs were calculated using three software packages. The relationship between computed molecular properties and elimination data collected from relevant literature, initially investigated with simple linear regression analysis, showed poor correlation (R-2  lt  0.25). Application of molecular weight or volume data as additional independent variable, multiple linear regression (MLR) revealed better correlations (R-2 similar to 0.38) between CCB renal and fecal elimination data and their lipophilicity. Excluding nimodipine from the calculations resulted in more acceptable correlations. The best correlations were established after computed lipophilicity descriptor and molecular weight were applied (R-2 = 0.66 with acceptable probability value).
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - The effect of the molecular properties of calcium channel blockers on their elimination route
VL  - 67
IS  - 3
SP  - 801
EP  - 806
DO  - 10.2298/ABS150127039T
ER  - 

@article{
author = "Trbojević-Stanković, Jasna and Odović, Jadranka and Jelić, Ratomir and Nešić, Dejan M. and Stojimirović, Biljana",
year = "2015",
abstract = "Calcium channel blockers (CCBs) are among the most widely used drugs in cardiovascular medicine. In this study, nine CCBs (amlodipine, felodipine, isradipine, nicardipine, nifedipine, nimodipine, nisoldipine, verapamil and diltiazem) were investigated to assess the relationship between their molecular properties and elimination data obtained from literature. The descriptors of the molecular properties of CCBs were calculated using three software packages. The relationship between computed molecular properties and elimination data collected from relevant literature, initially investigated with simple linear regression analysis, showed poor correlation (R-2  lt  0.25). Application of molecular weight or volume data as additional independent variable, multiple linear regression (MLR) revealed better correlations (R-2 similar to 0.38) between CCB renal and fecal elimination data and their lipophilicity. Excluding nimodipine from the calculations resulted in more acceptable correlations. The best correlations were established after computed lipophilicity descriptor and molecular weight were applied (R-2 = 0.66 with acceptable probability value).",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "The effect of the molecular properties of calcium channel blockers on their elimination route",
volume = "67",
number = "3",
pages = "801-806",
doi = "10.2298/ABS150127039T"
}

Trbojević-Stanković, J., Odović, J., Jelić, R., Nešić, D. M.,& Stojimirović, B.. (2015). The effect of the molecular properties of calcium channel blockers on their elimination route. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 67(3), 801-806.
https://doi.org/10.2298/ABS150127039T

Trbojević-Stanković J, Odović J, Jelić R, Nešić DM, Stojimirović B. The effect of the molecular properties of calcium channel blockers on their elimination route. in Archives of Biological Sciences. 2015;67(3):801-806.
doi:10.2298/ABS150127039T .

Trbojević-Stanković, Jasna, Odović, Jadranka, Jelić, Ratomir, Nešić, Dejan M., Stojimirović, Biljana, "The effect of the molecular properties of calcium channel blockers on their elimination route" in Archives of Biological Sciences, 67, no. 3 (2015):801-806,
https://doi.org/10.2298/ABS150127039T . .

TY  - JOUR
AU  - Trbojević-Stanković, Jasna
AU  - Odović, Jadranka
AU  - Jelić, Ratomir
AU  - Nešić, Dejan M.
AU  - Stojimirović, Biljana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2420
AB  - Angiotensin II receptor antagonists (ARBs) modulate the function of the renin-angiotensin-aldosterone system and are commonly prescribed antihypertensive drugs, especially in patients with renal failure. In this study, the relationship between several molecular properties of seven ARBs (candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, valsartan) and their fecal elimination data obtained from the literature were investigated. The ARB molecular descriptors were calculated using three software packages. Simple linear regression analysis showed the best correlation between fecal elimination data and lipophilicity descriptor, ClogP values (R-2 = 0.725). Multiple linear regression was applied to examine the correlation of ARBs' fecal elimination data with their lipophilicity and one additional, calculated descriptor. The best correlation (R-2 = 0.909 with an acceptable probability value, P  lt  0.05) was established between the ARB fecal elimination data and their lipophilicity and aqueous solubility data. Applying computed molecular descriptors for evaluating drug elimination is of great importance in drug research.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - The influence of certain molecular descriptors of fecal elimination of angiotensin II receptor antagonists
VL  - 67
IS  - 1
SP  - 103
EP  - 109
DO  - 10.2298/ABS141104011T
ER  - 

@article{
author = "Trbojević-Stanković, Jasna and Odović, Jadranka and Jelić, Ratomir and Nešić, Dejan M. and Stojimirović, Biljana",
year = "2015",
abstract = "Angiotensin II receptor antagonists (ARBs) modulate the function of the renin-angiotensin-aldosterone system and are commonly prescribed antihypertensive drugs, especially in patients with renal failure. In this study, the relationship between several molecular properties of seven ARBs (candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, valsartan) and their fecal elimination data obtained from the literature were investigated. The ARB molecular descriptors were calculated using three software packages. Simple linear regression analysis showed the best correlation between fecal elimination data and lipophilicity descriptor, ClogP values (R-2 = 0.725). Multiple linear regression was applied to examine the correlation of ARBs' fecal elimination data with their lipophilicity and one additional, calculated descriptor. The best correlation (R-2 = 0.909 with an acceptable probability value, P  lt  0.05) was established between the ARB fecal elimination data and their lipophilicity and aqueous solubility data. Applying computed molecular descriptors for evaluating drug elimination is of great importance in drug research.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "The influence of certain molecular descriptors of fecal elimination of angiotensin II receptor antagonists",
volume = "67",
number = "1",
pages = "103-109",
doi = "10.2298/ABS141104011T"
}

Trbojević-Stanković, J., Odović, J., Jelić, R., Nešić, D. M.,& Stojimirović, B.. (2015). The influence of certain molecular descriptors of fecal elimination of angiotensin II receptor antagonists. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 67(1), 103-109.
https://doi.org/10.2298/ABS141104011T

Trbojević-Stanković J, Odović J, Jelić R, Nešić DM, Stojimirović B. The influence of certain molecular descriptors of fecal elimination of angiotensin II receptor antagonists. in Archives of Biological Sciences. 2015;67(1):103-109.
doi:10.2298/ABS141104011T .

Trbojević-Stanković, Jasna, Odović, Jadranka, Jelić, Ratomir, Nešić, Dejan M., Stojimirović, Biljana, "The influence of certain molecular descriptors of fecal elimination of angiotensin II receptor antagonists" in Archives of Biological Sciences, 67, no. 1 (2015):103-109,
https://doi.org/10.2298/ABS141104011T . .

TY  - JOUR
AU  - Marković, Violeta
AU  - Erić, Slavica
AU  - Stanojković, Tatjana
AU  - Gligorijević, Nevenka
AU  - Aranđelović, Sandra
AU  - Todorović, Nina
AU  - Trifunović, Snežana
AU  - Manojlović, Nedeljko
AU  - Jelić, Ratomir
AU  - Joksović, Milan D.
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1555
AB  - Twenty five 4-aminomethylidene derivatives obtained from 3-phenyl-2-pyrazolin-5-one and 1,3-diphenyl-2-pyrazolin-5-one were synthesized and tested for their antiproliferative activity against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The compounds derived from 1,3-diphenyl-2-pyrazolin-5-one exhibited the most remarkable activity in the treatment of both cell lines. In vitro antiproliferative activities were accompanied by an important apoptotic fraction of both cell lines; also, compounds inhibited key endothelial cell functions implicated in invasion and angiogenesis. QSAR methods were performed in order to analyze the influence of structural features of the compounds investigated on the antiproliferative potential on MDA-MB-361 and MDA-MB-453 cancer cells. One-parameter heuristic analysis was performed and different whole molecule and fragmental descriptors were considered for rationalization of mechanism of interaction of these compounds with active place of hypothetical target included in tumorigenesis.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Bioorganic & Medicinal Chemistry Letters
T1  - Antiproliferative activity and QSAR studies of a series of new 4-aminomethylidene derivatives of some pyrazol-5-ones
VL  - 21
IS  - 15
SP  - 4416
EP  - 4421
DO  - 10.1016/j.bmcl.2011.06.025
ER  - 

@article{
author = "Marković, Violeta and Erić, Slavica and Stanojković, Tatjana and Gligorijević, Nevenka and Aranđelović, Sandra and Todorović, Nina and Trifunović, Snežana and Manojlović, Nedeljko and Jelić, Ratomir and Joksović, Milan D.",
year = "2011",
abstract = "Twenty five 4-aminomethylidene derivatives obtained from 3-phenyl-2-pyrazolin-5-one and 1,3-diphenyl-2-pyrazolin-5-one were synthesized and tested for their antiproliferative activity against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The compounds derived from 1,3-diphenyl-2-pyrazolin-5-one exhibited the most remarkable activity in the treatment of both cell lines. In vitro antiproliferative activities were accompanied by an important apoptotic fraction of both cell lines; also, compounds inhibited key endothelial cell functions implicated in invasion and angiogenesis. QSAR methods were performed in order to analyze the influence of structural features of the compounds investigated on the antiproliferative potential on MDA-MB-361 and MDA-MB-453 cancer cells. One-parameter heuristic analysis was performed and different whole molecule and fragmental descriptors were considered for rationalization of mechanism of interaction of these compounds with active place of hypothetical target included in tumorigenesis.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Bioorganic & Medicinal Chemistry Letters",
title = "Antiproliferative activity and QSAR studies of a series of new 4-aminomethylidene derivatives of some pyrazol-5-ones",
volume = "21",
number = "15",
pages = "4416-4421",
doi = "10.1016/j.bmcl.2011.06.025"
}

Marković, V., Erić, S., Stanojković, T., Gligorijević, N., Aranđelović, S., Todorović, N., Trifunović, S., Manojlović, N., Jelić, R.,& Joksović, M. D.. (2011). Antiproliferative activity and QSAR studies of a series of new 4-aminomethylidene derivatives of some pyrazol-5-ones. in Bioorganic & Medicinal Chemistry Letters
Pergamon-Elsevier Science Ltd, Oxford., 21(15), 4416-4421.
https://doi.org/10.1016/j.bmcl.2011.06.025

Marković V, Erić S, Stanojković T, Gligorijević N, Aranđelović S, Todorović N, Trifunović S, Manojlović N, Jelić R, Joksović MD. Antiproliferative activity and QSAR studies of a series of new 4-aminomethylidene derivatives of some pyrazol-5-ones. in Bioorganic & Medicinal Chemistry Letters. 2011;21(15):4416-4421.
doi:10.1016/j.bmcl.2011.06.025 .

Marković, Violeta, Erić, Slavica, Stanojković, Tatjana, Gligorijević, Nevenka, Aranđelović, Sandra, Todorović, Nina, Trifunović, Snežana, Manojlović, Nedeljko, Jelić, Ratomir, Joksović, Milan D., "Antiproliferative activity and QSAR studies of a series of new 4-aminomethylidene derivatives of some pyrazol-5-ones" in Bioorganic & Medicinal Chemistry Letters, 21, no. 15 (2011):4416-4421,
https://doi.org/10.1016/j.bmcl.2011.06.025 . .

TY  - JOUR
AU  - Dražić, Branka
AU  - Popović, Gordana
AU  - Jelić, Ratomir
AU  - Sladić, Dušan
AU  - Mitić, Dragana
AU  - Anđelković, Katarina
AU  - Tešić, Živoslav
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1296
AB  - Acid-base equilibria of Zn(II) and Fe(III) complexes with N',N'2-bis- [(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (ligand L1) and N',N'2-bis[(1E)- -1-(2-pyridyl)ethylidene]propanedihydrazide (ligand L2), i.e., [Fe(L1)Cl2(H2O)], [Fe(L2)Cl(H2O)]2+, [Zn(L1)(H2O)3]+ and [Zn(L2)(H2O)2]2+, which expressed cytotoxic activity, were investigated in aqueous media. The equilibrium constants were determined potentiometrically at 25°C at a constant ionic strength of 0.10 mol/dm3 (Na2SO4). The results showed that at pH  lt  8 both the Fe(III) complexes studied here have three, while [Zn(L1)(H2O)3]+ and [Zn(L2)(H2O)2]2+ have one and two titratable protons, respectively. Based on the obtained values for the equilibrium constants, protonation schemes of the examined complexes are proposed.
AB  - U ovom radu su proučavane kiselinsko-bazne ravnoteže u vodenim rastvorima kompleksa Zn(II) i Fe(III) sa N',N'2-bis[(1E)-1-(2-piridil)etiliden]etandihidrazidom (ligand L1) i N',N'2-bis[(1E)-1-(2-piridil)etiliden]propandihidrazidom (ligand L2), tj. [Fe(L1)Cl2(H2O)], [Fe(L2)Cl(H2O)]2+, [Zn(L1)(H2O)3]+, [Zn(L2)(H2O)2]2+, koji pokazuju citotoksičnu aktivnost. Ravnotežne konstante su određivane potenciometrijski, na temperaturi 25°C i pri konstantnoj jonskoj jačini 0,10 mol/dm3 Na2SO4. Utvrđeno je da u intervalu pH  lt  8 ispitivani Fe(III) kompleksi imaju tri, [Zn(L1)(H2O)3]+ jedan, a [Zn(L2)(H2O)2]2+ dva protona koji mogu da se titrišu. Na osnovu dobijenih vrednosti za konstante, pretpostavljene su i odgovarajuće protonacione sheme.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid
T1  - Kiselinsko-bazne ravnoteže kompleksa Fe(III) i Zn(II) sa kondenzacionim derivatima 2-acetilpiridina i hidrazida oksalne, odnosno malonske kiseline
VL  - 74
IS  - 3
SP  - 269
EP  - 277
DO  - 10.2298/JSC0903269D
ER  - 

@article{
author = "Dražić, Branka and Popović, Gordana and Jelić, Ratomir and Sladić, Dušan and Mitić, Dragana and Anđelković, Katarina and Tešić, Živoslav",
year = "2009",
abstract = "Acid-base equilibria of Zn(II) and Fe(III) complexes with N',N'2-bis- [(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (ligand L1) and N',N'2-bis[(1E)- -1-(2-pyridyl)ethylidene]propanedihydrazide (ligand L2), i.e., [Fe(L1)Cl2(H2O)], [Fe(L2)Cl(H2O)]2+, [Zn(L1)(H2O)3]+ and [Zn(L2)(H2O)2]2+, which expressed cytotoxic activity, were investigated in aqueous media. The equilibrium constants were determined potentiometrically at 25°C at a constant ionic strength of 0.10 mol/dm3 (Na2SO4). The results showed that at pH  lt  8 both the Fe(III) complexes studied here have three, while [Zn(L1)(H2O)3]+ and [Zn(L2)(H2O)2]2+ have one and two titratable protons, respectively. Based on the obtained values for the equilibrium constants, protonation schemes of the examined complexes are proposed., U ovom radu su proučavane kiselinsko-bazne ravnoteže u vodenim rastvorima kompleksa Zn(II) i Fe(III) sa N',N'2-bis[(1E)-1-(2-piridil)etiliden]etandihidrazidom (ligand L1) i N',N'2-bis[(1E)-1-(2-piridil)etiliden]propandihidrazidom (ligand L2), tj. [Fe(L1)Cl2(H2O)], [Fe(L2)Cl(H2O)]2+, [Zn(L1)(H2O)3]+, [Zn(L2)(H2O)2]2+, koji pokazuju citotoksičnu aktivnost. Ravnotežne konstante su određivane potenciometrijski, na temperaturi 25°C i pri konstantnoj jonskoj jačini 0,10 mol/dm3 Na2SO4. Utvrđeno je da u intervalu pH  lt  8 ispitivani Fe(III) kompleksi imaju tri, [Zn(L1)(H2O)3]+ jedan, a [Zn(L2)(H2O)2]2+ dva protona koji mogu da se titrišu. Na osnovu dobijenih vrednosti za konstante, pretpostavljene su i odgovarajuće protonacione sheme.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid, Kiselinsko-bazne ravnoteže kompleksa Fe(III) i Zn(II) sa kondenzacionim derivatima 2-acetilpiridina i hidrazida oksalne, odnosno malonske kiseline",
volume = "74",
number = "3",
pages = "269-277",
doi = "10.2298/JSC0903269D"
}

Dražić, B., Popović, G., Jelić, R., Sladić, D., Mitić, D., Anđelković, K.,& Tešić, Ž.. (2009). Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 74(3), 269-277.
https://doi.org/10.2298/JSC0903269D

Dražić B, Popović G, Jelić R, Sladić D, Mitić D, Anđelković K, Tešić Ž. Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid. in Journal of the Serbian Chemical Society. 2009;74(3):269-277.
doi:10.2298/JSC0903269D .

Dražić, Branka, Popović, Gordana, Jelić, Ratomir, Sladić, Dušan, Mitić, Dragana, Anđelković, Katarina, Tešić, Živoslav, "Acid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid" in Journal of the Serbian Chemical Society, 74, no. 3 (2009):269-277,
https://doi.org/10.2298/JSC0903269D . .