TY  - JOUR
AU  - Stojanović, Stefan
AU  - Nićiforović, Jovan
AU  - Živanović, Sandra
AU  - Odović, Jadranka
AU  - Jelić, Ratomir
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3614
AB  - bstract: Concomitant use of two or more drugs in therapy is becoming a more frequent phenomenon and clinically relevant drug–drug interactions at the level of binding to human serum albumin (HSA) are more often. The influence of fluoroquinolones–sparfloxacin, levofloxacin, and ciprofloxacin, on the interaction between tigecycline and HSA, was investigated in vitro by means of fluorescence and absorption spectroscopy. The results of UV–Vis and fluorescence spectroscopy showed that the fluorescence quenching of HSA was a result of the formation of new complexes through a static quenching process. The binding constants (Ka) and the number of binding sites (n) of all systems were calculated. The presence of sparfloxacin and ciprofloxacin increases and that of levofloxacin slightly decreases the binding constant of the HSA–tigecycline system. Competitive binding studies in the presence of site-specific markers showed that tigecycline was not significantly displaced by ibuprofen, but warfarin showed a significant displacement of tigecycline. These results suggest that the competitive binding of tigecycline and warfarin to HSA exists. The results confirm that the binding site of tigecycline is mainly located in Sudlow’s site I (subdomain IIA) of HSA. Graphic abstract: [Figure not available: see fulltext.
PB  - Springer
T2  - Monatshefte fur Chemie
T1  - Spectroscopic studies on the drug–drug interaction: the influence of fluoroquinolones on the affinity of tigecycline to human serum albumin and identification of the binding site
VL  - 151
SP  - 999
EP  - 1007
DO  - 10.1007/s00706-020-02627-0
ER  - 

@article{
author = "Stojanović, Stefan and Nićiforović, Jovan and Živanović, Sandra and Odović, Jadranka and Jelić, Ratomir",
year = "2020",
abstract = "bstract: Concomitant use of two or more drugs in therapy is becoming a more frequent phenomenon and clinically relevant drug–drug interactions at the level of binding to human serum albumin (HSA) are more often. The influence of fluoroquinolones–sparfloxacin, levofloxacin, and ciprofloxacin, on the interaction between tigecycline and HSA, was investigated in vitro by means of fluorescence and absorption spectroscopy. The results of UV–Vis and fluorescence spectroscopy showed that the fluorescence quenching of HSA was a result of the formation of new complexes through a static quenching process. The binding constants (Ka) and the number of binding sites (n) of all systems were calculated. The presence of sparfloxacin and ciprofloxacin increases and that of levofloxacin slightly decreases the binding constant of the HSA–tigecycline system. Competitive binding studies in the presence of site-specific markers showed that tigecycline was not significantly displaced by ibuprofen, but warfarin showed a significant displacement of tigecycline. These results suggest that the competitive binding of tigecycline and warfarin to HSA exists. The results confirm that the binding site of tigecycline is mainly located in Sudlow’s site I (subdomain IIA) of HSA. Graphic abstract: [Figure not available: see fulltext.",
publisher = "Springer",
journal = "Monatshefte fur Chemie",
title = "Spectroscopic studies on the drug–drug interaction: the influence of fluoroquinolones on the affinity of tigecycline to human serum albumin and identification of the binding site",
volume = "151",
pages = "999-1007",
doi = "10.1007/s00706-020-02627-0"
}

Stojanović, S., Nićiforović, J., Živanović, S., Odović, J.,& Jelić, R.. (2020). Spectroscopic studies on the drug–drug interaction: the influence of fluoroquinolones on the affinity of tigecycline to human serum albumin and identification of the binding site. in Monatshefte fur Chemie
Springer., 151, 999-1007.
https://doi.org/10.1007/s00706-020-02627-0

Stojanović S, Nićiforović J, Živanović S, Odović J, Jelić R. Spectroscopic studies on the drug–drug interaction: the influence of fluoroquinolones on the affinity of tigecycline to human serum albumin and identification of the binding site. in Monatshefte fur Chemie. 2020;151:999-1007.
doi:10.1007/s00706-020-02627-0 .

Stojanović, Stefan, Nićiforović, Jovan, Živanović, Sandra, Odović, Jadranka, Jelić, Ratomir, "Spectroscopic studies on the drug–drug interaction: the influence of fluoroquinolones on the affinity of tigecycline to human serum albumin and identification of the binding site" in Monatshefte fur Chemie, 151 (2020):999-1007,
https://doi.org/10.1007/s00706-020-02627-0 . .

TY  - JOUR
AU  - Veličković, Vesna
AU  - Simović, Slađana
AU  - Živanović, Sandra
AU  - Stojanović, Jasmina
AU  - Koravović, Mladen
AU  - Mihailović, Nataša
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2937
AB  - Objective. The aim of the present study was to investigate the frequency of allergic rhinitis in dysphonic professional voice users and to assess the correlation between allergic rhinitis and demographic characteristics (sex, ages and years in occupation) and presence of laryngopharyngeal reflux, as comorbidity health condition. Methods. A total of 104 male and female dysphonic patients who came to the Department of Otorhinolaryngology, Health Centre Kragujevac, Serbia because of the presence of dysphonia symptoms and who used their voice more than 4 hours per day at job were included in the study. The patients underwent rigid or transnasal fiberoptic laryngoscopy with videostroboscopy to assess the causes of dysphonia. Descriptive analysis, Pearson Chi-Square Tests and Binary Logistic regression were carried out using the SPSS 19.0 statistical software package. Results. Frequency of allergic rhinitis in dysphonic professional voice users was 44.2%. The patients were 1.1 times more likely to have allergic rhinitis with each passing year of life. Allergic rhinitis is with each year in occupation 0.89 times less frequent and 0.035 times less often in patients with laryngopharyngeal reflux. Conclusion. In dysphonic professional voice users, it has been found that allergic rhinitis occurs rarely with each year in occupation, which means that allergic rhinitis is not a predisposing factor for developing dysphonia, but year in occupation are a protective factor when it comes to the appearance of allergic rhinitis in the examined population.
AB  - Cilj. Cilj ovog rada bio je da se analizira učestalost alergijskog rinitisa kod profesionalnih korisnika glasa sa disfonijom, kao i povezanost između alergijskog rinitisa, demografskih karakteristika (pol, starost i dužina radnog staža) i laringofaringealnog refluksa u ispitivanoj populaciji. Metode. U studiju su uključena ukupno 104 ispitanika muškog i ženskog pola, koji su upućeni u Odeljenje za otorinolaringologiju Doma zdravlja Kragujevac, Srbija, zbog prisustva simptoma disfonije, a zaposleni su na poslovima koji zahtevaju upotrebu glasa više od četiri sata dnevno. Kod ispitanika je primenjena rigidna endovideostroboskopija ili transnazalna fibrooptička laringoskopija da bi se utvrdio uzrok disfonija. Statistička obrada podataka učinjena je primenom deskriptivne metode, Pirsonovog x2 testa i binarne logističke regresije, korišćenjem standardnog statističkog softverskog paketa SPSS 13.0. Rezultati. U ispitivanoj populaciji alergijski rinitis, identifikovan je kod 44,2% profesionalnih korisnika glasa sa disfonijom. U populaciji obuhvaćenoj istraživanjem alergijski rinitis se sa svakom godinom života 1,1 puta češće ispoljava, dok se sa svakom godinom radnog staža 0,89 puta ređe dijagnostikuje. Kod ispitivanih disfoničnih profesionalnih korisnika glasa, kod kojih je ustanovljen laringofaringealni refluks, alergijski rinitis je 0,035 puta ređe prisutan. Zaključak. Kod disfoničnih profesionalnih korisnika glasa, ustanovljeno je da se alergijski rinitis ređe javlja sa svakom godinom radnog staža, što znači da alergijski rinitis nije predisponirajući faktor za nastanak disfonije, već su godine radnog staža protektivni faktor kada je u pitanju pojava alergijskog rinitisa u ispitivanoj populaciji.
PB  - Srpsko lekarsko društvo - Okružna podružnica Kragujevac, Kragujevac
T2  - Medicinski časopis
T1  - The factors associated with allergic rhinitis in the dysphonic professional voice users
T1  - Faktori povezani s alergijskim rinitisom kod disfoničnih profesionalnih korisnika glasa
VL  - 51
IS  - 3
SP  - 73
EP  - 78
DO  - 10.5937/mckg51-16098
ER  - 

@article{
author = "Veličković, Vesna and Simović, Slađana and Živanović, Sandra and Stojanović, Jasmina and Koravović, Mladen and Mihailović, Nataša",
year = "2017",
abstract = "Objective. The aim of the present study was to investigate the frequency of allergic rhinitis in dysphonic professional voice users and to assess the correlation between allergic rhinitis and demographic characteristics (sex, ages and years in occupation) and presence of laryngopharyngeal reflux, as comorbidity health condition. Methods. A total of 104 male and female dysphonic patients who came to the Department of Otorhinolaryngology, Health Centre Kragujevac, Serbia because of the presence of dysphonia symptoms and who used their voice more than 4 hours per day at job were included in the study. The patients underwent rigid or transnasal fiberoptic laryngoscopy with videostroboscopy to assess the causes of dysphonia. Descriptive analysis, Pearson Chi-Square Tests and Binary Logistic regression were carried out using the SPSS 19.0 statistical software package. Results. Frequency of allergic rhinitis in dysphonic professional voice users was 44.2%. The patients were 1.1 times more likely to have allergic rhinitis with each passing year of life. Allergic rhinitis is with each year in occupation 0.89 times less frequent and 0.035 times less often in patients with laryngopharyngeal reflux. Conclusion. In dysphonic professional voice users, it has been found that allergic rhinitis occurs rarely with each year in occupation, which means that allergic rhinitis is not a predisposing factor for developing dysphonia, but year in occupation are a protective factor when it comes to the appearance of allergic rhinitis in the examined population., Cilj. Cilj ovog rada bio je da se analizira učestalost alergijskog rinitisa kod profesionalnih korisnika glasa sa disfonijom, kao i povezanost između alergijskog rinitisa, demografskih karakteristika (pol, starost i dužina radnog staža) i laringofaringealnog refluksa u ispitivanoj populaciji. Metode. U studiju su uključena ukupno 104 ispitanika muškog i ženskog pola, koji su upućeni u Odeljenje za otorinolaringologiju Doma zdravlja Kragujevac, Srbija, zbog prisustva simptoma disfonije, a zaposleni su na poslovima koji zahtevaju upotrebu glasa više od četiri sata dnevno. Kod ispitanika je primenjena rigidna endovideostroboskopija ili transnazalna fibrooptička laringoskopija da bi se utvrdio uzrok disfonija. Statistička obrada podataka učinjena je primenom deskriptivne metode, Pirsonovog x2 testa i binarne logističke regresije, korišćenjem standardnog statističkog softverskog paketa SPSS 13.0. Rezultati. U ispitivanoj populaciji alergijski rinitis, identifikovan je kod 44,2% profesionalnih korisnika glasa sa disfonijom. U populaciji obuhvaćenoj istraživanjem alergijski rinitis se sa svakom godinom života 1,1 puta češće ispoljava, dok se sa svakom godinom radnog staža 0,89 puta ređe dijagnostikuje. Kod ispitivanih disfoničnih profesionalnih korisnika glasa, kod kojih je ustanovljen laringofaringealni refluks, alergijski rinitis je 0,035 puta ređe prisutan. Zaključak. Kod disfoničnih profesionalnih korisnika glasa, ustanovljeno je da se alergijski rinitis ređe javlja sa svakom godinom radnog staža, što znači da alergijski rinitis nije predisponirajući faktor za nastanak disfonije, već su godine radnog staža protektivni faktor kada je u pitanju pojava alergijskog rinitisa u ispitivanoj populaciji.",
publisher = "Srpsko lekarsko društvo - Okružna podružnica Kragujevac, Kragujevac",
journal = "Medicinski časopis",
title = "The factors associated with allergic rhinitis in the dysphonic professional voice users, Faktori povezani s alergijskim rinitisom kod disfoničnih profesionalnih korisnika glasa",
volume = "51",
number = "3",
pages = "73-78",
doi = "10.5937/mckg51-16098"
}

Veličković, V., Simović, S., Živanović, S., Stojanović, J., Koravović, M.,& Mihailović, N.. (2017). The factors associated with allergic rhinitis in the dysphonic professional voice users. in Medicinski časopis
Srpsko lekarsko društvo - Okružna podružnica Kragujevac, Kragujevac., 51(3), 73-78.
https://doi.org/10.5937/mckg51-16098

Veličković V, Simović S, Živanović S, Stojanović J, Koravović M, Mihailović N. The factors associated with allergic rhinitis in the dysphonic professional voice users. in Medicinski časopis. 2017;51(3):73-78.
doi:10.5937/mckg51-16098 .

Veličković, Vesna, Simović, Slađana, Živanović, Sandra, Stojanović, Jasmina, Koravović, Mladen, Mihailović, Nataša, "The factors associated with allergic rhinitis in the dysphonic professional voice users" in Medicinski časopis, 51, no. 3 (2017):73-78,
https://doi.org/10.5937/mckg51-16098 . .