TY  - JOUR
AU  - Stojanović, Goran M
AU  - Milić, Lazar
AU  - Endro, Ali A
AU  - Simić, Mitar
AU  - Nikolić, Ines
AU  - Savić, Miroslav
AU  - Savić, Snežana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5539
AB  - In this article, a sensing element for detection of date rape drugs in drinks is presented. The element consists of a three-dimensional printed holder, in which two embroidered electrodes have been fixed, forming a capacitive structure. As the dielectric properties of the liquid between these electrodes’ changes, the capacitance and consequently the impedance are changed. For experimental purposes, diazepam, a model rape drug, sucrose, and sodium chloride, which are used as control ingredients, were dissolved in a 40% V/V alcoholic beverage, serving as solutions for testing and comparison. The selectivity, repeatability, and sensitivity of the proposed sensor were tested. The sensitivity of detection of 1 mg/ml of diazepam in drinks was 0.92628 Ωl/mg, sucrose was 0.94774 Ωl/mg and sodium chloride was 2.46867 Ωl/mg, at 1 MHz. Moreover, with the use of the Cole impedance model, the selectivity of the sensor in the detection of diazepam, through the Nyquist plot and parameter estimation, has been achieved. Sensor repeatability was calculated through the relative standard deviation with the result for 1 mg/ml of diazepam dissolved in alcohol on 1 MHz being 2.48, in terms of impedance modulus. The presented sensor platform can successfully detect drugs in drinks and can protect from many cases of such assaults in a real world.
PB  - SAGE Publications Ltd
T2  - Textile Research Journal
T1  - Textile-based wearable device for detection of date rape drugs in drinks
DO  - 10.1177/00405175231218740
ER  - 

@article{
author = "Stojanović, Goran M and Milić, Lazar and Endro, Ali A and Simić, Mitar and Nikolić, Ines and Savić, Miroslav and Savić, Snežana",
year = "2023",
abstract = "In this article, a sensing element for detection of date rape drugs in drinks is presented. The element consists of a three-dimensional printed holder, in which two embroidered electrodes have been fixed, forming a capacitive structure. As the dielectric properties of the liquid between these electrodes’ changes, the capacitance and consequently the impedance are changed. For experimental purposes, diazepam, a model rape drug, sucrose, and sodium chloride, which are used as control ingredients, were dissolved in a 40% V/V alcoholic beverage, serving as solutions for testing and comparison. The selectivity, repeatability, and sensitivity of the proposed sensor were tested. The sensitivity of detection of 1 mg/ml of diazepam in drinks was 0.92628 Ωl/mg, sucrose was 0.94774 Ωl/mg and sodium chloride was 2.46867 Ωl/mg, at 1 MHz. Moreover, with the use of the Cole impedance model, the selectivity of the sensor in the detection of diazepam, through the Nyquist plot and parameter estimation, has been achieved. Sensor repeatability was calculated through the relative standard deviation with the result for 1 mg/ml of diazepam dissolved in alcohol on 1 MHz being 2.48, in terms of impedance modulus. The presented sensor platform can successfully detect drugs in drinks and can protect from many cases of such assaults in a real world.",
publisher = "SAGE Publications Ltd",
journal = "Textile Research Journal",
title = "Textile-based wearable device for detection of date rape drugs in drinks",
doi = "10.1177/00405175231218740"
}

Stojanović, G. M., Milić, L., Endro, A. A., Simić, M., Nikolić, I., Savić, M.,& Savić, S.. (2023). Textile-based wearable device for detection of date rape drugs in drinks. in Textile Research Journal
SAGE Publications Ltd..
https://doi.org/10.1177/00405175231218740

Stojanović GM, Milić L, Endro AA, Simić M, Nikolić I, Savić M, Savić S. Textile-based wearable device for detection of date rape drugs in drinks. in Textile Research Journal. 2023;.
doi:10.1177/00405175231218740 .

Stojanović, Goran M, Milić, Lazar, Endro, Ali A, Simić, Mitar, Nikolić, Ines, Savić, Miroslav, Savić, Snežana, "Textile-based wearable device for detection of date rape drugs in drinks" in Textile Research Journal (2023),
https://doi.org/10.1177/00405175231218740 . .

TY  - JOUR
AU  - Nikolić, Ines
AU  - Simić, Mitar
AU  - Pantelić, Ivana
AU  - Stojanović, Goran
AU  - Antić-Stanković, Jelena
AU  - Marković, Bojan
AU  - Savić, Snežana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4328
AB  - So far, various approaches have been proposed to improve dermal drug delivery. The
use of chemical penetration enhancers has a long history of application, while methods based on
the electrical current (such as iontophoresis) stand out as promising “active” techniques. Aiming to
evaluate the contribution of different approaches to dermal delivery, in this work curcumin-loaded
nanoemulsions with and without monoterpenes (eucalyptol or pinene) as chemical penetration
enhancers, and a custom-made adhesive dermal delivery system based on iontophoresis were
designed and assessed. In an in vivo study applying skin bioengineering techniques, their safety
profile was proven. Three examined iontophoresis protocols, with total skin exposure time of 15 min
(continuous flow for 15 min (15-0); 3 min of continuous flow and 2 min pause (3-2; 5 cycles) and
5 min of continuous flow and 1 min pause (5-1; 3 cycles) were equally efficient in terms of the
total amount of curcumin that penetrated through the superficial skin layers ( in vivo tape stripping)
(Q3-2 = 7.04 ± 3.21 μg/cm2; Q5-1 = 6.66 ± 2.11 μg/cm2; Q15-0 = 6.96 ± 3.21 μg/cm2), significantly
more efficient compared to the referent nanoemulsion and monoterpene-containing nanoemulsions.
Further improvement of an efficient mobile adhesive system for iontophoresis would be a practical
contribution in the field of dermal drug application.
PB  - MDPI
T2  - Pharmaceutics
T1  - Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis
VL  - 14
IS  - 6
DO  - 10.3390/pharmaceutics14061144
ER  - 

@article{
author = "Nikolić, Ines and Simić, Mitar and Pantelić, Ivana and Stojanović, Goran and Antić-Stanković, Jelena and Marković, Bojan and Savić, Snežana",
year = "2022",
abstract = "So far, various approaches have been proposed to improve dermal drug delivery. The
use of chemical penetration enhancers has a long history of application, while methods based on
the electrical current (such as iontophoresis) stand out as promising “active” techniques. Aiming to
evaluate the contribution of different approaches to dermal delivery, in this work curcumin-loaded
nanoemulsions with and without monoterpenes (eucalyptol or pinene) as chemical penetration
enhancers, and a custom-made adhesive dermal delivery system based on iontophoresis were
designed and assessed. In an in vivo study applying skin bioengineering techniques, their safety
profile was proven. Three examined iontophoresis protocols, with total skin exposure time of 15 min
(continuous flow for 15 min (15-0); 3 min of continuous flow and 2 min pause (3-2; 5 cycles) and
5 min of continuous flow and 1 min pause (5-1; 3 cycles) were equally efficient in terms of the
total amount of curcumin that penetrated through the superficial skin layers ( in vivo tape stripping)
(Q3-2 = 7.04 ± 3.21 μg/cm2; Q5-1 = 6.66 ± 2.11 μg/cm2; Q15-0 = 6.96 ± 3.21 μg/cm2), significantly
more efficient compared to the referent nanoemulsion and monoterpene-containing nanoemulsions.
Further improvement of an efficient mobile adhesive system for iontophoresis would be a practical
contribution in the field of dermal drug application.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis",
volume = "14",
number = "6",
doi = "10.3390/pharmaceutics14061144"
}

Nikolić, I., Simić, M., Pantelić, I., Stojanović, G., Antić-Stanković, J., Marković, B.,& Savić, S.. (2022). Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis. in Pharmaceutics
MDPI., 14(6).
https://doi.org/10.3390/pharmaceutics14061144

Nikolić I, Simić M, Pantelić I, Stojanović G, Antić-Stanković J, Marković B, Savić S. Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis. in Pharmaceutics. 2022;14(6).
doi:10.3390/pharmaceutics14061144 .

Nikolić, Ines, Simić, Mitar, Pantelić, Ivana, Stojanović, Goran, Antić-Stanković, Jelena, Marković, Bojan, Savić, Snežana, "Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis" in Pharmaceutics, 14, no. 6 (2022),
https://doi.org/10.3390/pharmaceutics14061144 . .