@conference{
author = "Vukadinović, Aleksandar and Knežević, Nikola and Janković, Drina and Radović, Magdalena and Perić, Marko and Mirković, Marija and Milanović, Zorana and Stanković, Dragana and Vranješ‐Đurić, Sanja and Prijović, Željko and Erić, Slavica",
year = "2022",
abstract = "Radioisotopes such as 90 Y that emit beta-particles are well known to be suitable for
use in tumor therapy. In addition, the delivery of a variety of therapeutics using
nanoparticles has become a large field of research in recent years. This study examined the
biological behavior of three different micro- and nanoparticle formulations that carry the
therapeutic 90 Y radioisotope. The first formulation was 90 Y-labeled citrate-coated
superparamagnetic iron-oxide nanoparticles ( 90 Y-CA-SPIONs), the second was mesoporous
silica-coated superparamagnetic iron-oxide nanoparticles ( 90 Y-Mag-MSN), and third
formulation was 90 Y-labelled albumin microspheres ( 90 Y-AMS). All three formulations are
shown to be stable over the relevant period of radioisotope decay. The sizes of particles were
22nm, 386nm, and 38μm for 90 Y-CA-SPIONs, 90 Y-Mag-MSN, and 90 Y-AMS, respectively. The
biodistribution studies were done using tumor-bearing BALB/c mice. The results showed
that, after the i.v. injection, the biodistribution was dependent on particle sizes. Thus,
smaller particles (90 Y-CA-SPIONs and 90 Y-Mag-MSN) were taken up mainly by the liver and
spleen (>90%ID), and larger particles (90Y-AMS) were taken up entirely by the lungs. None of
the formulations had a tumor uptake of more than 1%ID. After the direct intratumoral
injection, all three formulations have shown to be stable, and radioactivity remained only in
tumors during the four days of follow-up. This study confirms the delivery of nanoparticles
to solid tumors after i.v. injection is a challenge due to the low uptake by tumor tissue.
Nevertheless, all three examined materials have shown to be suitable for a direct
intratumoral application, and 90 Y-AMS is suitable for radioembolization (SIRT) procedures., Radioizotopi, kao što je 90 Y, koji emituju beta-čestice su pogodni za upotrebu u terapiji
tumora. Pored toga, isporuka terapeutika pomoću nanočestica predstavlja poslednjih godina
veliko polje istraživanja. U ovoj studiji je ispitivano biološko ponašanje tri različite
formulacije mikro- i nanočestica obeleženih terapeutskim radioizotopom 90 Y. Prvu
formulaciju su činile 90 Y-obeležene su perparamagnetne nanočestice gvožđe-oksida obložene
citratom (90 Y-CA-SPIONs), druga je bila superparamagnetna nanočestica gvožđe-oksida
obložena mezoporoznom silikom (90 Y-Mag-MSN), a treća formulacija je bila 90 Y-obeležena
albuminska mikrosfera ( 90 Y-AMS). Pokazalo se da su sve tri formulacije stabilne tokom
perioda poluraspada radioizotopa. Veličine čestica bile su 22 nm, 386 nm i 38 μm za 90 Y-CA-
SPION, 90 Y-Mag-MSN i 90 Y-AMS, respektivno. Studije biodistribucije su urađene korišćenjem
BALB/c miševa sa tumorskim ksenograftima. Rezultati su pokazali da, nakon i.v. injekcije,
biodistribucija radioobeleženih čestica zavisi od njihove veličine. Prema tome, manje čestice
( 90 Y-CA-SPIONs i 90 Y-Mag-MSN) se uglavnom nakupljaju u jetri i slezini (>90%ID), a veće
( 90 Y-AMS) u plućima. Nakupljanje čestica u tumorima je bilo manje od 1%ID. Posle direktne
lokalne intratumoralne injekcije, sve tri vrste radioobeleženih čestica su pokazale visoku
stabilnost, tako da se radioaktivnost zadržala isključivo u tumorskom tkivu tokom četiri dana
praćenja. Ova studija potvrđuje da je nakupljanje nanočestica u solidnim tumorima nakon i.v.
injekcije izazov zbog malog preuzimanja od strane tumorskog tkiva. Ipak, sve tri ispitivane
vrste čestica su se pokazale pogodnim za direktnu lokalnu intratumoralnu primenu, a 90 Y-
AMS je pogodan i za terapiju radioembolizacijom (SIRT).",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Biological behaviour of 90Y-labeled micro- and nanoparticles in tumor-bearing mice, Biološko ponašanje 90Y‐obeleženih mikro‐ i nanočestica kod miševa sa tumorskim ksenograftima",
volume = "72",
number = "4 suplement",
pages = "S522-S523",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4594"
}
