@article{
author = "Pokrajac, Milena and Miljković, Branislava and Simić, D and Brzaković, B and Galetin, A",
year = "1998",
abstract = "The objective of this study was to assess both pharmacokinetic properties and bioavailability of a newly developed cotrimoxazole preparation (Bioprim(R) tablets, 80 mg of trimethoprim/400 mg sulfamethoxazole), in comparison with a reference preparation commercially available (Bactrim(R) tablets, 80 mg of trimethoprim/400 mg of sulfamethoxazole). The pharmacokinetics and bioavailability of cotrimoxazole from these preparations were compared in an open randomized crossover study in 12 healthy males. Plasma concentrations of trimethoprim and sulfamethoxazole were measured by HPLC after protein precipitation. Noncompartmental pharmacokinetic analysis was performed on the plasma concentration-time data. The obtained pharmacokinetic values (C-max, t(max), beta, t(1/2)(beta), CL, V-d, AUC36, AUC(infinity)) of both trimethoprim and sulfamethoxazole determined in our study agreed with values reported in the literature. Westlake's and Nonparametric probability tests with the 90% confidence intervals, for both trimethoprim and sulfamethoxazole gave the differences within 80 and 120%, for all necessary measures (C-max, t(max) and AUC(infinity)). Statistical analysis of the data has shown that the preparations have similar pharmacokinetic profiles and therefore can be considered equally bioavailable.",
publisher = "Govi-Verlag Gmbh, Eschborn",
journal = "Pharmazie",
title = "Comparative pharmacokinetics and bioavailability of two cotrimoxazole preparations",
volume = "53",
number = "7",
pages = "470-472",
url = "https://hdl.handle.net/21.15107/rcub_farfar_175"
}
