TY  - JOUR
AU  - Žunić, G.D
AU  - Spasić, S
AU  - Jelić-Ivanović, Zorana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1799
AB  - Whole blood and/or plasma amino acids are useful for monitoring whole body protein and amino acid metabolism in an organism under various physiological and pathophysiological conditions. Various methodological procedures are in use for their measurement in biological fluids. From the time when capillary electrophoresis was introduced as a technology offering rapid separation of various ionic and/or ionizable compounds with low sample and solvent consumption, there were many attempts to use it for the measurement of amino acids present in physiological fluids. As a rule, these methods require derivatization procedures for detection purposes. Here, we present two protocols for the analysis of free amino acids employing free zone capillary electrophoresis. Main advantage of both methods is an absence of any derivatization procedures that permits the analysis of free amino acid in physiological fluids. The method using direct detection and carrier electrolyte consisting of disodium monophosphate (10 mM at pH 2.90) permits determination of compounds that absorb in UV region (aromatic and sulfur containing amino acids, as well as some peptides, such as carnosine, reduced and oxidized glutathione). The other method uses indirect absorbance detection, employing 8 mM p-amino salicylic acid buffered with sodium carbonate at pH 10.2 as running electrolyte. It permits quantification of 30 underivatized physiological amino acids and peptides. In our experience, factorial design represents a useful tool for final optimization of the electrophoretic conditions if it is necessary.
T2  - Methods in Molecular Biology
T1  - Capillary electrophoresis of free amino acids in physiological fluids without derivatization employing direct or indirect absorbance detection
VL  - 828
SP  - 243
EP  - 254
DO  - 10.1007/978-1-61779-445-2_19
ER  - 

@article{
author = "Žunić, G.D and Spasić, S and Jelić-Ivanović, Zorana",
year = "2012",
abstract = "Whole blood and/or plasma amino acids are useful for monitoring whole body protein and amino acid metabolism in an organism under various physiological and pathophysiological conditions. Various methodological procedures are in use for their measurement in biological fluids. From the time when capillary electrophoresis was introduced as a technology offering rapid separation of various ionic and/or ionizable compounds with low sample and solvent consumption, there were many attempts to use it for the measurement of amino acids present in physiological fluids. As a rule, these methods require derivatization procedures for detection purposes. Here, we present two protocols for the analysis of free amino acids employing free zone capillary electrophoresis. Main advantage of both methods is an absence of any derivatization procedures that permits the analysis of free amino acid in physiological fluids. The method using direct detection and carrier electrolyte consisting of disodium monophosphate (10 mM at pH 2.90) permits determination of compounds that absorb in UV region (aromatic and sulfur containing amino acids, as well as some peptides, such as carnosine, reduced and oxidized glutathione). The other method uses indirect absorbance detection, employing 8 mM p-amino salicylic acid buffered with sodium carbonate at pH 10.2 as running electrolyte. It permits quantification of 30 underivatized physiological amino acids and peptides. In our experience, factorial design represents a useful tool for final optimization of the electrophoretic conditions if it is necessary.",
journal = "Methods in Molecular Biology",
title = "Capillary electrophoresis of free amino acids in physiological fluids without derivatization employing direct or indirect absorbance detection",
volume = "828",
pages = "243-254",
doi = "10.1007/978-1-61779-445-2_19"
}

Žunić, G.D, Spasić, S.,& Jelić-Ivanović, Z.. (2012). Capillary electrophoresis of free amino acids in physiological fluids without derivatization employing direct or indirect absorbance detection. in Methods in Molecular Biology, 828, 243-254.
https://doi.org/10.1007/978-1-61779-445-2_19

Žunić G, Spasić S, Jelić-Ivanović Z. Capillary electrophoresis of free amino acids in physiological fluids without derivatization employing direct or indirect absorbance detection. in Methods in Molecular Biology. 2012;828:243-254.
doi:10.1007/978-1-61779-445-2_19 .

Žunić, G.D, Spasić, S, Jelić-Ivanović, Zorana, "Capillary electrophoresis of free amino acids in physiological fluids without derivatization employing direct or indirect absorbance detection" in Methods in Molecular Biology, 828 (2012):243-254,
https://doi.org/10.1007/978-1-61779-445-2_19 . .

TY  - CHAP
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, S
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1796
AB  - Elevated serum low-density lipoprotein cholesterol (LDLcholesterol) concentration is firmly established as a risk factor for atherosclerosis and cardiovascular disease (CVD). Yet, a number of CVD patients have LDL-cholesterol levels within the recommended range, suggesting the need for advanced lipid testing to determine residual risk. In this manner, further improvement of risk assessment might be accomplished through a more detailed insight into qualitative and quantitative characteristics of LDL particles. Plasma LDL population comprise complex spectrum of particles of different size, density and lipid composition. There is now ample of evidence that certain LDL subclasses, particularly small, dense LDL particles, are superior to LDLcholesterol in terms of CVD risk prediction. Furthermore, elevation of small, dense LDL particles is also observed in various atherosclerosisrelated conditions, such as end-stage renal disease or ischemic stroke. Whereas the measurement of LDL-cholesterol concentrations has proven clinical utility, the usefulness of LDL particles characterisation in clinical practice needs to be further explored. Understanding of structural complexity of LDL particles and their functional consequences might improve prevention and prognosis of atherosclerosis-related diseases, leading toward more specialized therapeutic approaches. Therefore, the questions of whom, when and how to asses small, dense LDL particles still remain open.
PB  - Nova Science Publishers, Inc.
T2  - Dyslipidemia: Causes, Diagnosis and Treatment
T1  - Qualitative and quantitative characteristics of low-density lipoproteins in atherosclerosisrelated diseases
SP  - 95
EP  - 122
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1796
ER  - 

@inbook{
author = "Vekić, Jelena and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Spasić, S",
year = "2012",
abstract = "Elevated serum low-density lipoprotein cholesterol (LDLcholesterol) concentration is firmly established as a risk factor for atherosclerosis and cardiovascular disease (CVD). Yet, a number of CVD patients have LDL-cholesterol levels within the recommended range, suggesting the need for advanced lipid testing to determine residual risk. In this manner, further improvement of risk assessment might be accomplished through a more detailed insight into qualitative and quantitative characteristics of LDL particles. Plasma LDL population comprise complex spectrum of particles of different size, density and lipid composition. There is now ample of evidence that certain LDL subclasses, particularly small, dense LDL particles, are superior to LDLcholesterol in terms of CVD risk prediction. Furthermore, elevation of small, dense LDL particles is also observed in various atherosclerosisrelated conditions, such as end-stage renal disease or ischemic stroke. Whereas the measurement of LDL-cholesterol concentrations has proven clinical utility, the usefulness of LDL particles characterisation in clinical practice needs to be further explored. Understanding of structural complexity of LDL particles and their functional consequences might improve prevention and prognosis of atherosclerosis-related diseases, leading toward more specialized therapeutic approaches. Therefore, the questions of whom, when and how to asses small, dense LDL particles still remain open.",
publisher = "Nova Science Publishers, Inc.",
journal = "Dyslipidemia: Causes, Diagnosis and Treatment",
booktitle = "Qualitative and quantitative characteristics of low-density lipoproteins in atherosclerosisrelated diseases",
pages = "95-122",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1796"
}

Vekić, J., Zeljković, A., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V.,& Spasić, S.. (2012). Qualitative and quantitative characteristics of low-density lipoproteins in atherosclerosisrelated diseases. in Dyslipidemia: Causes, Diagnosis and Treatment
Nova Science Publishers, Inc.., 95-122.
https://hdl.handle.net/21.15107/rcub_farfar_1796

Vekić J, Zeljković A, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Spasić S. Qualitative and quantitative characteristics of low-density lipoproteins in atherosclerosisrelated diseases. in Dyslipidemia: Causes, Diagnosis and Treatment. 2012;:95-122.
https://hdl.handle.net/21.15107/rcub_farfar_1796 .

Vekić, Jelena, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Spasić, S, "Qualitative and quantitative characteristics of low-density lipoproteins in atherosclerosisrelated diseases" in Dyslipidemia: Causes, Diagnosis and Treatment (2012):95-122,
https://hdl.handle.net/21.15107/rcub_farfar_1796 .

TY  - CHAP
AU  - Vekić, Jelena
AU  - Kotur-Stevuljević, Jelena
AU  - Zeljković, Aleksandra
AU  - Stefanović, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, S
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1436
AB  - PON1 is a high density lipoprotein (HDL)-associated serum enzyme. Its primary function is to degrade commonly used insecticides and nerve gases. PON1 is found to be more effective than lecithin:cholesterol acyltransferase (LCAT) or apoA-I in protecting low density lipoproteins (LDL) against oxidation. This chapter reveals that the antioxidative properties of HDL can be compromised under conditions associated with accelerated atherosclerosis. It reveals that PON1 is largely responsible for the breakdown of lipid peroxides before they accumulate in LDL particles. In addition, PON1 also renders HDL resistant to oxidation and hydrolyzes lipid peroxides in human atherosclerotic lesions. The study also reveals that PON1 is primarily a lactonase acting upon certain lactones/hydroxyl acids. Therefore, one of the physiological roles of PON1 is the metabolism of lipid species arising from the oxidation of polyunsaturated fatty acids. The relationship between PON1 and HDL relies on a unique reciprocal arrangement. HDL facilitates the secretion of PON1 and offers a hydrophobic harbor for its anchoring. The chapter also provides a hydrophobic environment that is essential for optimal PON1 activity. In return, the enzyme prevents the oxidation of HDL and stimulates the cholesterol efflux from cells. Therefore, the association between PON1 and HDL is considered in both normal and pathological conditions.
PB  - Elsevier Inc.
T2  - The HDL Handbook
T1  - Serum paraoxonase (PON1) and its interactions with HDL: Relationship between PON1 and oxidative stress
SP  - 77
EP  - 98
DO  - 10.1016/B978-0-12-382171-3.10005-1
ER  - 

@inbook{
author = "Vekić, Jelena and Kotur-Stevuljević, Jelena and Zeljković, Aleksandra and Stefanović, Aleksandra and Jelić-Ivanović, Zorana and Spasić, S and Spasojević-Kalimanovska, Vesna",
year = "2010",
abstract = "PON1 is a high density lipoprotein (HDL)-associated serum enzyme. Its primary function is to degrade commonly used insecticides and nerve gases. PON1 is found to be more effective than lecithin:cholesterol acyltransferase (LCAT) or apoA-I in protecting low density lipoproteins (LDL) against oxidation. This chapter reveals that the antioxidative properties of HDL can be compromised under conditions associated with accelerated atherosclerosis. It reveals that PON1 is largely responsible for the breakdown of lipid peroxides before they accumulate in LDL particles. In addition, PON1 also renders HDL resistant to oxidation and hydrolyzes lipid peroxides in human atherosclerotic lesions. The study also reveals that PON1 is primarily a lactonase acting upon certain lactones/hydroxyl acids. Therefore, one of the physiological roles of PON1 is the metabolism of lipid species arising from the oxidation of polyunsaturated fatty acids. The relationship between PON1 and HDL relies on a unique reciprocal arrangement. HDL facilitates the secretion of PON1 and offers a hydrophobic harbor for its anchoring. The chapter also provides a hydrophobic environment that is essential for optimal PON1 activity. In return, the enzyme prevents the oxidation of HDL and stimulates the cholesterol efflux from cells. Therefore, the association between PON1 and HDL is considered in both normal and pathological conditions.",
publisher = "Elsevier Inc.",
journal = "The HDL Handbook",
booktitle = "Serum paraoxonase (PON1) and its interactions with HDL: Relationship between PON1 and oxidative stress",
pages = "77-98",
doi = "10.1016/B978-0-12-382171-3.10005-1"
}

Vekić, J., Kotur-Stevuljević, J., Zeljković, A., Stefanović, A., Jelić-Ivanović, Z., Spasić, S.,& Spasojević-Kalimanovska, V.. (2010). Serum paraoxonase (PON1) and its interactions with HDL: Relationship between PON1 and oxidative stress. in The HDL Handbook
Elsevier Inc.., 77-98.
https://doi.org/10.1016/B978-0-12-382171-3.10005-1

Vekić J, Kotur-Stevuljević J, Zeljković A, Stefanović A, Jelić-Ivanović Z, Spasić S, Spasojević-Kalimanovska V. Serum paraoxonase (PON1) and its interactions with HDL: Relationship between PON1 and oxidative stress. in The HDL Handbook. 2010;:77-98.
doi:10.1016/B978-0-12-382171-3.10005-1 .

Vekić, Jelena, Kotur-Stevuljević, Jelena, Zeljković, Aleksandra, Stefanović, Aleksandra, Jelić-Ivanović, Zorana, Spasić, S, Spasojević-Kalimanovska, Vesna, "Serum paraoxonase (PON1) and its interactions with HDL: Relationship between PON1 and oxidative stress" in The HDL Handbook (2010):77-98,
https://doi.org/10.1016/B978-0-12-382171-3.10005-1 . .

TY  - JOUR
AU  - Bogavac-Stanojević, Nataša
AU  - Jelić-Ivanović, Zorana
AU  - Đurović, Srđan
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, Slavica
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Memon, Lidija
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/610
AB  - High plasma HDL-cholesterol (HDL-c) is a well-established protective factor in coronary artery disease (CAD). One of its potential protective mechanisms is the inhibition of the cytokine-induced upregulation of expression of cellular adhesion molecules (CAMs). High sCAM levels were found to be associated with low HDL-c in some studies performed mostly in hyperlipidemic subjects, but this association has not yet been investigated in CAD patients. In addition, conflicting results were obtained from in vitro studies that explored the proposed HDL effect on cytokine-induced CAM expression. The aim of the present case-control study was to investigate whether low HDL-c values are associated with CAM overexpression in normolipidemic CAD patients and healthy individuals, matched according to age and gender. Plasma HDL-c, sICAM-1, sVCAM-1, and sE-selectin were measured in 37 normolipidemic patients with angiographically verified coronary artery disease and in 52 healthy normolipidemic subjects. The sCAM values obtained in the subjects (patients or controls) with low HDL-c levels ( lt 1.03 mmol/L) were compared with the values in the subjects with high HDL-c (>= 1.03 mmol/L). No significant difference was found between sICAM-1, sVCAM-1, and E-selectin values obtained in subjects with low and high HDL-c, either among the patients or the healthy controls. In conclusion, low HDL-c levels are not associated with CAM overexpression in normolipidemic CAD patients and healthy subjects.
PB  - International Heart Journal Association, Tokyo
T2  - International Heart Journal
T1  - Lack of association between low HDL-cholesterol and elevated circulating cellular adhesion molecules in normolipidemic CAD patients and healthy subjects
VL  - 46
IS  - 4
SP  - 593
EP  - 600
DO  - 10.1536/ihj.46.593
ER  - 

@article{
author = "Bogavac-Stanojević, Nataša and Jelić-Ivanović, Zorana and Đurović, Srđan and Spasojević-Kalimanovska, Vesna and Spasić, Slavica and Kalimanovska-Oštrić, Dimitra and Memon, Lidija",
year = "2005",
abstract = "High plasma HDL-cholesterol (HDL-c) is a well-established protective factor in coronary artery disease (CAD). One of its potential protective mechanisms is the inhibition of the cytokine-induced upregulation of expression of cellular adhesion molecules (CAMs). High sCAM levels were found to be associated with low HDL-c in some studies performed mostly in hyperlipidemic subjects, but this association has not yet been investigated in CAD patients. In addition, conflicting results were obtained from in vitro studies that explored the proposed HDL effect on cytokine-induced CAM expression. The aim of the present case-control study was to investigate whether low HDL-c values are associated with CAM overexpression in normolipidemic CAD patients and healthy individuals, matched according to age and gender. Plasma HDL-c, sICAM-1, sVCAM-1, and sE-selectin were measured in 37 normolipidemic patients with angiographically verified coronary artery disease and in 52 healthy normolipidemic subjects. The sCAM values obtained in the subjects (patients or controls) with low HDL-c levels ( lt 1.03 mmol/L) were compared with the values in the subjects with high HDL-c (>= 1.03 mmol/L). No significant difference was found between sICAM-1, sVCAM-1, and E-selectin values obtained in subjects with low and high HDL-c, either among the patients or the healthy controls. In conclusion, low HDL-c levels are not associated with CAM overexpression in normolipidemic CAD patients and healthy subjects.",
publisher = "International Heart Journal Association, Tokyo",
journal = "International Heart Journal",
title = "Lack of association between low HDL-cholesterol and elevated circulating cellular adhesion molecules in normolipidemic CAD patients and healthy subjects",
volume = "46",
number = "4",
pages = "593-600",
doi = "10.1536/ihj.46.593"
}

Bogavac-Stanojević, N., Jelić-Ivanović, Z., Đurović, S., Spasojević-Kalimanovska, V., Spasić, S., Kalimanovska-Oštrić, D.,& Memon, L.. (2005). Lack of association between low HDL-cholesterol and elevated circulating cellular adhesion molecules in normolipidemic CAD patients and healthy subjects. in International Heart Journal
International Heart Journal Association, Tokyo., 46(4), 593-600.
https://doi.org/10.1536/ihj.46.593

Bogavac-Stanojević N, Jelić-Ivanović Z, Đurović S, Spasojević-Kalimanovska V, Spasić S, Kalimanovska-Oštrić D, Memon L. Lack of association between low HDL-cholesterol and elevated circulating cellular adhesion molecules in normolipidemic CAD patients and healthy subjects. in International Heart Journal. 2005;46(4):593-600.
doi:10.1536/ihj.46.593 .

Bogavac-Stanojević, Nataša, Jelić-Ivanović, Zorana, Đurović, Srđan, Spasojević-Kalimanovska, Vesna, Spasić, Slavica, Kalimanovska-Oštrić, Dimitra, Memon, Lidija, "Lack of association between low HDL-cholesterol and elevated circulating cellular adhesion molecules in normolipidemic CAD patients and healthy subjects" in International Heart Journal, 46, no. 4 (2005):593-600,
https://doi.org/10.1536/ihj.46.593 . .

TY  - JOUR
AU  - Topić, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, S
AU  - Stanković, I
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/323
PB  - Wiley
T2  - Acta Paediatrica
T1  - Distribution of alpha-1-antitrypsin phenotypes in Serbian newborns and children with liver disease
VL  - 91
IS  - 6
SP  - 726
EP  - 727
DO  - 10.1111/j.1651-2227.2002.tb03314.x
UR  - https://hdl.handle.net/21.15107/rcub_farfar_323
ER  - 

@article{
author = "Topić, Aleksandra and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Spasić, S and Stanković, I",
year = "2002",
publisher = "Wiley",
journal = "Acta Paediatrica",
title = "Distribution of alpha-1-antitrypsin phenotypes in Serbian newborns and children with liver disease",
volume = "91",
number = "6",
pages = "726-727",
doi = "10.1111/j.1651-2227.2002.tb03314.x",
url = "https://hdl.handle.net/21.15107/rcub_farfar_323"
}

Topić, A., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Spasić, S.,& Stanković, I.. (2002). Distribution of alpha-1-antitrypsin phenotypes in Serbian newborns and children with liver disease. in Acta Paediatrica
Wiley., 91(6), 726-727.
https://doi.org/10.1111/j.1651-2227.2002.tb03314.x
https://hdl.handle.net/21.15107/rcub_farfar_323

Topić A, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Spasić S, Stanković I. Distribution of alpha-1-antitrypsin phenotypes in Serbian newborns and children with liver disease. in Acta Paediatrica. 2002;91(6):726-727.
doi:10.1111/j.1651-2227.2002.tb03314.x
https://hdl.handle.net/21.15107/rcub_farfar_323 .

Topić, Aleksandra, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Spasić, S, Stanković, I, "Distribution of alpha-1-antitrypsin phenotypes in Serbian newborns and children with liver disease" in Acta Paediatrica, 91, no. 6 (2002):726-727,
https://doi.org/10.1111/j.1651-2227.2002.tb03314.x .,
https://hdl.handle.net/21.15107/rcub_farfar_323 .

TY  - JOUR
AU  - Jugović, M
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, S
AU  - Nikolić, Z
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/316
AB  - Patients with chronic renal insufficiency on hemodialysis develop lipoprotein abnormalities that may contribute to increased risk for atherosclerosis. The atherogenic risk for chronic renal insufficiency patients and dialysis treated patients was assessed by measuring total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol and calculating the ratio: TC/HDL-C and LDL-C/HDL-C. The examined group consisted of 18 cronic renal insufficiency patients and 60 patients on hemodialysis. The results were compared to a control group of 85 voluntary blood donors. Serum lipid parameters were examined by standard methods. All lipid parameters in hemodialysis patients were statistically different compared to the control group (p lt 0.05) while chronic renal insufficiency patients showed significant difference only in triglycerides and HDL-cholesterol. Hypertriglyceridemia was present in both examined groups of patients and HDL-cholesterol was lower within both groups. All calculated atherogenic ratios were higher for patients than the control group. Lipid parameters were compared between chronic renal insufficiency and hemodialysis patients but statistical significantly difference was obtained only for HDL-cholesterol (p lt 0.05). We conclude that increased values of triglycerides and lower HDL-cholesterol in chronic renal insufficiency patients contribute to high incidence of cardiovascular disease. Chronic renal insufficiency patients have impaired reverse cholesterol transport from peripheral cells to lipoproteins, decreased levels of HDL-cholesterol, hypertriglyceridemia prevalence of small, dense LDL and increased levels of potentially atherogenic remnant particles.
PB  - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2  - Jugoslovenska medicinska biohemija
T1  - Lipoprotein metabolism abnormalities in patients with chronic renal insufficiency
VL  - 21
IS  - 4
SP  - 323
EP  - 330
DO  - 10.2298/JMH0204323J
ER  - 

@article{
author = "Jugović, M and Spasojević-Kalimanovska, Vesna and Spasić, S and Nikolić, Z",
year = "2002",
abstract = "Patients with chronic renal insufficiency on hemodialysis develop lipoprotein abnormalities that may contribute to increased risk for atherosclerosis. The atherogenic risk for chronic renal insufficiency patients and dialysis treated patients was assessed by measuring total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol and calculating the ratio: TC/HDL-C and LDL-C/HDL-C. The examined group consisted of 18 cronic renal insufficiency patients and 60 patients on hemodialysis. The results were compared to a control group of 85 voluntary blood donors. Serum lipid parameters were examined by standard methods. All lipid parameters in hemodialysis patients were statistically different compared to the control group (p lt 0.05) while chronic renal insufficiency patients showed significant difference only in triglycerides and HDL-cholesterol. Hypertriglyceridemia was present in both examined groups of patients and HDL-cholesterol was lower within both groups. All calculated atherogenic ratios were higher for patients than the control group. Lipid parameters were compared between chronic renal insufficiency and hemodialysis patients but statistical significantly difference was obtained only for HDL-cholesterol (p lt 0.05). We conclude that increased values of triglycerides and lower HDL-cholesterol in chronic renal insufficiency patients contribute to high incidence of cardiovascular disease. Chronic renal insufficiency patients have impaired reverse cholesterol transport from peripheral cells to lipoproteins, decreased levels of HDL-cholesterol, hypertriglyceridemia prevalence of small, dense LDL and increased levels of potentially atherogenic remnant particles.",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Lipoprotein metabolism abnormalities in patients with chronic renal insufficiency",
volume = "21",
number = "4",
pages = "323-330",
doi = "10.2298/JMH0204323J"
}

Jugović, M., Spasojević-Kalimanovska, V., Spasić, S.,& Nikolić, Z.. (2002). Lipoprotein metabolism abnormalities in patients with chronic renal insufficiency. in Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 21(4), 323-330.
https://doi.org/10.2298/JMH0204323J

Jugović M, Spasojević-Kalimanovska V, Spasić S, Nikolić Z. Lipoprotein metabolism abnormalities in patients with chronic renal insufficiency. in Jugoslovenska medicinska biohemija. 2002;21(4):323-330.
doi:10.2298/JMH0204323J .

Jugović, M, Spasojević-Kalimanovska, Vesna, Spasić, S, Nikolić, Z, "Lipoprotein metabolism abnormalities in patients with chronic renal insufficiency" in Jugoslovenska medicinska biohemija, 21, no. 4 (2002):323-330,
https://doi.org/10.2298/JMH0204323J . .

TY  - JOUR
AU  - Zunić, G
AU  - Jelić-Ivanović, Zorana
AU  - Colić, M
AU  - Spasić, S
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/328
AB  - This report describes a rapid, single-run procedure, based on the optimization of capillary electrophoresis (CE) and indirect absorbance detection capabilities, which was developed for the separation and quantification of 30 underivatized physiological amino acids and peptides, usually present in biological fluids. p-Aminosalicylic acid buffered with sodium carbonate at pH 10.2 +/- 0.1 was used as the running electrolyte. Electrophoresis, carried out in a capillary (87 cmx75 mum) at 15 kV potential (normal polarity), separated the examined compounds within 30 min. Limits of detection ranged from 1.93 to 20.08 mumol/l (median 6.71 mumol/l). The method was linear within the 50-200 mumol/l concentration range (r ranged from 0.684 to 0.989, median r=0.934). Within run migration times precision was good (median C.V.=0.7%). Less favorable within run peak area precision (median C.V.=6.6%) was obtained. The analytical procedure presented was successfully tested for separation and quantification of amino acids in physiological fluids, such as plasma or supernatant of macrophage cultures. Sample preparations require only a protein precipitation and dilution step.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
T1  - Optimization of a free separation of 30 free amino acids and peptides by capillary zone electrophoresis with indirect absorbance detection: a potential for quantification in physiological fluids
VL  - 772
IS  - 1
SP  - 19
EP  - 33
UR  - https://hdl.handle.net/21.15107/rcub_farfar_328
ER  - 

@article{
author = "Zunić, G and Jelić-Ivanović, Zorana and Colić, M and Spasić, S",
year = "2002",
abstract = "This report describes a rapid, single-run procedure, based on the optimization of capillary electrophoresis (CE) and indirect absorbance detection capabilities, which was developed for the separation and quantification of 30 underivatized physiological amino acids and peptides, usually present in biological fluids. p-Aminosalicylic acid buffered with sodium carbonate at pH 10.2 +/- 0.1 was used as the running electrolyte. Electrophoresis, carried out in a capillary (87 cmx75 mum) at 15 kV potential (normal polarity), separated the examined compounds within 30 min. Limits of detection ranged from 1.93 to 20.08 mumol/l (median 6.71 mumol/l). The method was linear within the 50-200 mumol/l concentration range (r ranged from 0.684 to 0.989, median r=0.934). Within run migration times precision was good (median C.V.=0.7%). Less favorable within run peak area precision (median C.V.=6.6%) was obtained. The analytical procedure presented was successfully tested for separation and quantification of amino acids in physiological fluids, such as plasma or supernatant of macrophage cultures. Sample preparations require only a protein precipitation and dilution step.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences",
title = "Optimization of a free separation of 30 free amino acids and peptides by capillary zone electrophoresis with indirect absorbance detection: a potential for quantification in physiological fluids",
volume = "772",
number = "1",
pages = "19-33",
url = "https://hdl.handle.net/21.15107/rcub_farfar_328"
}

Zunić, G., Jelić-Ivanović, Z., Colić, M.,& Spasić, S.. (2002). Optimization of a free separation of 30 free amino acids and peptides by capillary zone electrophoresis with indirect absorbance detection: a potential for quantification in physiological fluids. in Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
Elsevier Science BV, Amsterdam., 772(1), 19-33.
https://hdl.handle.net/21.15107/rcub_farfar_328

Zunić G, Jelić-Ivanović Z, Colić M, Spasić S. Optimization of a free separation of 30 free amino acids and peptides by capillary zone electrophoresis with indirect absorbance detection: a potential for quantification in physiological fluids. in Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 2002;772(1):19-33.
https://hdl.handle.net/21.15107/rcub_farfar_328 .

Zunić, G, Jelić-Ivanović, Zorana, Colić, M, Spasić, S, "Optimization of a free separation of 30 free amino acids and peptides by capillary zone electrophoresis with indirect absorbance detection: a potential for quantification in physiological fluids" in Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 772, no. 1 (2002):19-33,
https://hdl.handle.net/21.15107/rcub_farfar_328 .

TY  - JOUR
AU  - Jelić-Ivanović, Zorana
AU  - Stanković, B
AU  - Topić, Aleksandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, S
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/246
AB  - Background. Serum alpha(1)-antitrypsin (alpha 1AT) antigen concentration is elevated in malignancies as the result of acute phase reaction. In the present study, we examined whether the alpha 1AT elevation in monoclonal gammopathies was accompanied by an adequate increase of its functional activity. Methods. In this case-control study, serum alpha 1AT concentration was measured in 187 ambulatory patients with monoclonal gammopathies and 320 healthy blood donors matched according to sex and age. The alpha 1AT antigen concentration was assayed by immunonephelometry, whereas its functional activity was measured as trypsin inhibitory capacity (TIC), The specific alpha 1AT inhibitory activity (SIA) was calculated, defined as the TIC/antigen concentration ratio. Results. The alpha 1AT antigen concentrations obtained in the patients' samples were very significantly higher as compared with the corresponding values in the control group (mean+/-SD =134+/-41.9% of normal, p lt 0.001). However, the TIC values were higher in the patients than in the healthy controls only by 4% (104+/-23.8%, p lt 0.05). The specific alpha 1AT activity was very significantly lower in the patients, as compared with the controls (p lt 0.001), indicating that serum alpha 1AT in monoclonal gammopathies was partially inactive. Conclusions. As poor correlation between the TIC values and the antigen concentrations was obtained in the patient group as well as the decreased specific alpha 1AT activities, the TIC values in patients with monoclonal gammopathies should be interpreted with caution.
PB  - Edizioni Minerva Medica, Turin
T2  - Panminerva Medica
T1  - Low serum alpha-1-antitrypsin specific activity in monoclonal gammopathies
VL  - 42
IS  - 1
SP  - 17
EP  - 21
UR  - https://hdl.handle.net/21.15107/rcub_farfar_246
ER  - 

@article{
author = "Jelić-Ivanović, Zorana and Stanković, B and Topić, Aleksandra and Spasojević-Kalimanovska, Vesna and Spasić, S",
year = "2000",
abstract = "Background. Serum alpha(1)-antitrypsin (alpha 1AT) antigen concentration is elevated in malignancies as the result of acute phase reaction. In the present study, we examined whether the alpha 1AT elevation in monoclonal gammopathies was accompanied by an adequate increase of its functional activity. Methods. In this case-control study, serum alpha 1AT concentration was measured in 187 ambulatory patients with monoclonal gammopathies and 320 healthy blood donors matched according to sex and age. The alpha 1AT antigen concentration was assayed by immunonephelometry, whereas its functional activity was measured as trypsin inhibitory capacity (TIC), The specific alpha 1AT inhibitory activity (SIA) was calculated, defined as the TIC/antigen concentration ratio. Results. The alpha 1AT antigen concentrations obtained in the patients' samples were very significantly higher as compared with the corresponding values in the control group (mean+/-SD =134+/-41.9% of normal, p lt 0.001). However, the TIC values were higher in the patients than in the healthy controls only by 4% (104+/-23.8%, p lt 0.05). The specific alpha 1AT activity was very significantly lower in the patients, as compared with the controls (p lt 0.001), indicating that serum alpha 1AT in monoclonal gammopathies was partially inactive. Conclusions. As poor correlation between the TIC values and the antigen concentrations was obtained in the patient group as well as the decreased specific alpha 1AT activities, the TIC values in patients with monoclonal gammopathies should be interpreted with caution.",
publisher = "Edizioni Minerva Medica, Turin",
journal = "Panminerva Medica",
title = "Low serum alpha-1-antitrypsin specific activity in monoclonal gammopathies",
volume = "42",
number = "1",
pages = "17-21",
url = "https://hdl.handle.net/21.15107/rcub_farfar_246"
}

Jelić-Ivanović, Z., Stanković, B., Topić, A., Spasojević-Kalimanovska, V.,& Spasić, S.. (2000). Low serum alpha-1-antitrypsin specific activity in monoclonal gammopathies. in Panminerva Medica
Edizioni Minerva Medica, Turin., 42(1), 17-21.
https://hdl.handle.net/21.15107/rcub_farfar_246

Jelić-Ivanović Z, Stanković B, Topić A, Spasojević-Kalimanovska V, Spasić S. Low serum alpha-1-antitrypsin specific activity in monoclonal gammopathies. in Panminerva Medica. 2000;42(1):17-21.
https://hdl.handle.net/21.15107/rcub_farfar_246 .

Jelić-Ivanović, Zorana, Stanković, B, Topić, Aleksandra, Spasojević-Kalimanovska, Vesna, Spasić, S, "Low serum alpha-1-antitrypsin specific activity in monoclonal gammopathies" in Panminerva Medica, 42, no. 1 (2000):17-21,
https://hdl.handle.net/21.15107/rcub_farfar_246 .

TY  - JOUR
AU  - Zunić, G
AU  - Spasić, S
AU  - Jelić-Ivanović, Zorana
PY  - 1999
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/221
AB  - Nitrite and nitrate levels in physiological fluids are commonly used as an index of nitric oxide production. We developed simple and rapid method for the determination of these anions by capillary zone electrophoresis employing berate buffer (pH 10, 100 mmol/l) as running electrolyte. The anions were analyzed in plasma and cerebrospinal fluid (CSF) without deproteinization of the samples. Electrophoresis was carried out in a capillary (36.5 cm X 75 mu m) at a potential of 15 kV, with on-column UV detection at 214 nm. Mean retention times for nitrite and nitrates were 4.631 and 5.152 min, respectively. The method was linear (r = 0.999) within a 1-500 mu mol/l concentration range. Physiological levels of nitrate in plasma (40.2 mu mol/l) and CSF (15.3 mu mol/l) could be determined with good precision (coefficients of variation  lt 6%) and accuracy (recoveries of added nitrate to plasma and CSF were 97.4 and 104.5%, respectively). Measurements of the physiological levels of nitrite in plasma (6.1 mu mol/l) and CSF (0.9 mu mol/l) were less precise and accurate.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Chromatography B
T1  - Simple and rapid method for the measurement of nitrite and nitrate in human plasma and cerebrospinal fluid by capillary electrophoresis
VL  - 727
IS  - 1-2
SP  - 73
EP  - 79
DO  - 10.1016/S0378-4347(99)00054-7
ER  - 

@article{
author = "Zunić, G and Spasić, S and Jelić-Ivanović, Zorana",
year = "1999",
abstract = "Nitrite and nitrate levels in physiological fluids are commonly used as an index of nitric oxide production. We developed simple and rapid method for the determination of these anions by capillary zone electrophoresis employing berate buffer (pH 10, 100 mmol/l) as running electrolyte. The anions were analyzed in plasma and cerebrospinal fluid (CSF) without deproteinization of the samples. Electrophoresis was carried out in a capillary (36.5 cm X 75 mu m) at a potential of 15 kV, with on-column UV detection at 214 nm. Mean retention times for nitrite and nitrates were 4.631 and 5.152 min, respectively. The method was linear (r = 0.999) within a 1-500 mu mol/l concentration range. Physiological levels of nitrate in plasma (40.2 mu mol/l) and CSF (15.3 mu mol/l) could be determined with good precision (coefficients of variation  lt 6%) and accuracy (recoveries of added nitrate to plasma and CSF were 97.4 and 104.5%, respectively). Measurements of the physiological levels of nitrite in plasma (6.1 mu mol/l) and CSF (0.9 mu mol/l) were less precise and accurate.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Chromatography B",
title = "Simple and rapid method for the measurement of nitrite and nitrate in human plasma and cerebrospinal fluid by capillary electrophoresis",
volume = "727",
number = "1-2",
pages = "73-79",
doi = "10.1016/S0378-4347(99)00054-7"
}

Zunić, G., Spasić, S.,& Jelić-Ivanović, Z.. (1999). Simple and rapid method for the measurement of nitrite and nitrate in human plasma and cerebrospinal fluid by capillary electrophoresis. in Journal of Chromatography B
Elsevier Science BV, Amsterdam., 727(1-2), 73-79.
https://doi.org/10.1016/S0378-4347(99)00054-7

Zunić G, Spasić S, Jelić-Ivanović Z. Simple and rapid method for the measurement of nitrite and nitrate in human plasma and cerebrospinal fluid by capillary electrophoresis. in Journal of Chromatography B. 1999;727(1-2):73-79.
doi:10.1016/S0378-4347(99)00054-7 .

Zunić, G, Spasić, S, Jelić-Ivanović, Zorana, "Simple and rapid method for the measurement of nitrite and nitrate in human plasma and cerebrospinal fluid by capillary electrophoresis" in Journal of Chromatography B, 727, no. 1-2 (1999):73-79,
https://doi.org/10.1016/S0378-4347(99)00054-7 . .

TY  - JOUR
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, S
AU  - Spasojević-Kalimanovska, Vesna
PY  - 1998
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/191
AB  - Clinical accuracy of a laboratory test refers its ability to differentiate alternative states of healths, i.e, to classify patients into clinicaly relevant groups. Basic parameters and methods used for the assessment of clinical accuracy are the following: specificity, sensitivity, ROC-curve, predictive values and diagnostic efficiency. Sensitivity and specificity are inherent characteristics of laboratory tests, which are not influenced by the prevalence of target disease. ROC-curve, which is a sensitivity/specificity pair for different cut-off limits in the whole range of the obtained values, offers the best insight into the clinical performance of a laboratory test. The use of ROC-curve is the best way to compare clinical accuracies of different tests and to identify the cutoff limits that yield optimal test sensitivity and specificity. Predictive values are influenced by the disease prevalence, and are used mostly for interpretation of results or in building sequential diagnostic strategies. Diagnostic efficiency is a combined parameter which is easy to obtain, but is not very useful for the assessment of clinical accuracy.
PB  - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2  - Jugoslovenska medicinska biohemija
T1  - Clinical value of laboratory measurements
VL  - 17
IS  - 4
SP  - 367
EP  - 375
UR  - https://hdl.handle.net/21.15107/rcub_farfar_191
ER  - 

@article{
author = "Jelić-Ivanović, Zorana and Spasić, S and Spasojević-Kalimanovska, Vesna",
year = "1998",
abstract = "Clinical accuracy of a laboratory test refers its ability to differentiate alternative states of healths, i.e, to classify patients into clinicaly relevant groups. Basic parameters and methods used for the assessment of clinical accuracy are the following: specificity, sensitivity, ROC-curve, predictive values and diagnostic efficiency. Sensitivity and specificity are inherent characteristics of laboratory tests, which are not influenced by the prevalence of target disease. ROC-curve, which is a sensitivity/specificity pair for different cut-off limits in the whole range of the obtained values, offers the best insight into the clinical performance of a laboratory test. The use of ROC-curve is the best way to compare clinical accuracies of different tests and to identify the cutoff limits that yield optimal test sensitivity and specificity. Predictive values are influenced by the disease prevalence, and are used mostly for interpretation of results or in building sequential diagnostic strategies. Diagnostic efficiency is a combined parameter which is easy to obtain, but is not very useful for the assessment of clinical accuracy.",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Clinical value of laboratory measurements",
volume = "17",
number = "4",
pages = "367-375",
url = "https://hdl.handle.net/21.15107/rcub_farfar_191"
}

Jelić-Ivanović, Z., Spasić, S.,& Spasojević-Kalimanovska, V.. (1998). Clinical value of laboratory measurements. in Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 17(4), 367-375.
https://hdl.handle.net/21.15107/rcub_farfar_191

Jelić-Ivanović Z, Spasić S, Spasojević-Kalimanovska V. Clinical value of laboratory measurements. in Jugoslovenska medicinska biohemija. 1998;17(4):367-375.
https://hdl.handle.net/21.15107/rcub_farfar_191 .

Jelić-Ivanović, Zorana, Spasić, S, Spasojević-Kalimanovska, Vesna, "Clinical value of laboratory measurements" in Jugoslovenska medicinska biohemija, 17, no. 4 (1998):367-375,
https://hdl.handle.net/21.15107/rcub_farfar_191 .

TY  - JOUR
AU  - Perović, M
AU  - Spasić, S
AU  - Bilbija, V
AU  - Bolits, Z
AU  - Jelić-Ivanović, Zorana
PY  - 1997
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/159
AB  - The cholesterol values were epidemiologically studied in adults (N=21257) in the region of Vojvodina, Yugoslavia. All investigated persons were divided according to sex (7 319 males and 13 938 females) and age (in six decades). The cholesterol concentrations were assayed by the enzymatic method and the data were analyzed by GraphROC(R) for Windows and the Statgraphics(R) statistical software. The frequency distribution in each group was fitted to the Gaussian type by mathematical method and reference limits were calculated as 5% and 95% percentiles. Reference limits in all groups were higher than the values recommended by WHO. Cholesterol values in males and females increased with the age and reached the peak in the group of 50-60 yrs for men and in the group of 60-70 yrs for women. There was a significant difference between the mean values in subsequent age-groups. In the youngest age-group there were 50% of males and 50.4% of females with cholesterol levels below 5.2 mmol/L, and 17.5% of males and 14.5% of females with cholesterol levels above 6.5 mmol/L. The number of subjects with recommended values of cholesterol decreased with the age and in the group of 50-60 yrs we found 12.6% of males and 9.1% of females with cholesterol values below 5.2 mmol/L. In the same age-group, the largest number of subjects with cholesterol levels above 6.5 mmol/L was found: 50.7% of males and 60.1% of females. The study shows a very high prevalence of cholesterol risk factor among the adults in Vojvodina.
PB  - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2  - Jugoslovenska medicinska biohemija
T1  - Age and sex dependent cholesterol values of adults in region Vojvodina, Yugoslavia
T1  - Vrednosti holesterola u zavisnosti od pola i starosti kod odrasle populacije Vojvodine
VL  - 16
IS  - 1
SP  - 21
EP  - 24
UR  - https://hdl.handle.net/21.15107/rcub_farfar_159
ER  - 

@article{
author = "Perović, M and Spasić, S and Bilbija, V and Bolits, Z and Jelić-Ivanović, Zorana",
year = "1997",
abstract = "The cholesterol values were epidemiologically studied in adults (N=21257) in the region of Vojvodina, Yugoslavia. All investigated persons were divided according to sex (7 319 males and 13 938 females) and age (in six decades). The cholesterol concentrations were assayed by the enzymatic method and the data were analyzed by GraphROC(R) for Windows and the Statgraphics(R) statistical software. The frequency distribution in each group was fitted to the Gaussian type by mathematical method and reference limits were calculated as 5% and 95% percentiles. Reference limits in all groups were higher than the values recommended by WHO. Cholesterol values in males and females increased with the age and reached the peak in the group of 50-60 yrs for men and in the group of 60-70 yrs for women. There was a significant difference between the mean values in subsequent age-groups. In the youngest age-group there were 50% of males and 50.4% of females with cholesterol levels below 5.2 mmol/L, and 17.5% of males and 14.5% of females with cholesterol levels above 6.5 mmol/L. The number of subjects with recommended values of cholesterol decreased with the age and in the group of 50-60 yrs we found 12.6% of males and 9.1% of females with cholesterol values below 5.2 mmol/L. In the same age-group, the largest number of subjects with cholesterol levels above 6.5 mmol/L was found: 50.7% of males and 60.1% of females. The study shows a very high prevalence of cholesterol risk factor among the adults in Vojvodina.",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Age and sex dependent cholesterol values of adults in region Vojvodina, Yugoslavia, Vrednosti holesterola u zavisnosti od pola i starosti kod odrasle populacije Vojvodine",
volume = "16",
number = "1",
pages = "21-24",
url = "https://hdl.handle.net/21.15107/rcub_farfar_159"
}

Perović, M., Spasić, S., Bilbija, V., Bolits, Z.,& Jelić-Ivanović, Z.. (1997). Age and sex dependent cholesterol values of adults in region Vojvodina, Yugoslavia. in Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 16(1), 21-24.
https://hdl.handle.net/21.15107/rcub_farfar_159

Perović M, Spasić S, Bilbija V, Bolits Z, Jelić-Ivanović Z. Age and sex dependent cholesterol values of adults in region Vojvodina, Yugoslavia. in Jugoslovenska medicinska biohemija. 1997;16(1):21-24.
https://hdl.handle.net/21.15107/rcub_farfar_159 .

Perović, M, Spasić, S, Bilbija, V, Bolits, Z, Jelić-Ivanović, Zorana, "Age and sex dependent cholesterol values of adults in region Vojvodina, Yugoslavia" in Jugoslovenska medicinska biohemija, 16, no. 1 (1997):21-24,
https://hdl.handle.net/21.15107/rcub_farfar_159 .

TY  - JOUR
AU  - Perović, M
AU  - Spasić, S
AU  - Bilbija, V
AU  - Bolits, Z
AU  - Jelić-Ivanović, Zorana
PY  - 1997
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/157
AB  - The triglycerides values were epidemiologically studied in 21257 adults (aged 20-80 yrs.) in the region of Vojvodina, Yugoslavia. All investigated persons were divided according to sex (7319 males and 13 938 females) and age (in six decades). The triglycerides concentrations were assayed by the enzymatic method and data were analyzed by the GraphROC for Windows(R) and Statgraphics(R) statistical software. The frequency distributions in all groups were fitted to the log-Gaussian type by mathematical method and reference limits were calculated as 5 and 95 percentiles. Reference limits in all groups were higher than the values recommended by WHO. The obtained mean values in all males, except in subjects older than 70 years, were significantly higher than the values in females. Triglycerides values were age dependent and we found a significant difference among mean values in all age-groups. The lowest mean values were in the youngest subjects: males: (x) over bar = 1.65 +/- 0.98 mmol/L, females: (x) over bar = 1.22 +/- 0.61 mmol/L and the highest in the group of 40-50 yrs for males: (x) over bar = 2.47 +/- 1.53 mmol/L and in the group of 50-60 yrs for females: (x) over bar = 2.0 +/- 1.03 mmol/L. In the youngest age-group there were 60.4% of males and 81.3% of females with triglycerides level of  lt 1.7 mmol/L, and 21.3% of males and 7.7% of females with triglycerides level of >2.3 mmol/L. The largest number of subjects with triglycerides of >2.3 mmol/L was found in mates aged 40-50 yrs (45.3%) and in females aged 50-60 yrs (41.4%).
PB  - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2  - Jugoslovenska medicinska biohemija
T1  - Age- and sex-dependent values of triglycerides in adults in the region of Vojvodina, Yugoslavia
VL  - 16
IS  - 3
SP  - 155
EP  - 160
UR  - https://hdl.handle.net/21.15107/rcub_farfar_157
ER  - 

@article{
author = "Perović, M and Spasić, S and Bilbija, V and Bolits, Z and Jelić-Ivanović, Zorana",
year = "1997",
abstract = "The triglycerides values were epidemiologically studied in 21257 adults (aged 20-80 yrs.) in the region of Vojvodina, Yugoslavia. All investigated persons were divided according to sex (7319 males and 13 938 females) and age (in six decades). The triglycerides concentrations were assayed by the enzymatic method and data were analyzed by the GraphROC for Windows(R) and Statgraphics(R) statistical software. The frequency distributions in all groups were fitted to the log-Gaussian type by mathematical method and reference limits were calculated as 5 and 95 percentiles. Reference limits in all groups were higher than the values recommended by WHO. The obtained mean values in all males, except in subjects older than 70 years, were significantly higher than the values in females. Triglycerides values were age dependent and we found a significant difference among mean values in all age-groups. The lowest mean values were in the youngest subjects: males: (x) over bar = 1.65 +/- 0.98 mmol/L, females: (x) over bar = 1.22 +/- 0.61 mmol/L and the highest in the group of 40-50 yrs for males: (x) over bar = 2.47 +/- 1.53 mmol/L and in the group of 50-60 yrs for females: (x) over bar = 2.0 +/- 1.03 mmol/L. In the youngest age-group there were 60.4% of males and 81.3% of females with triglycerides level of  lt 1.7 mmol/L, and 21.3% of males and 7.7% of females with triglycerides level of >2.3 mmol/L. The largest number of subjects with triglycerides of >2.3 mmol/L was found in mates aged 40-50 yrs (45.3%) and in females aged 50-60 yrs (41.4%).",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Age- and sex-dependent values of triglycerides in adults in the region of Vojvodina, Yugoslavia",
volume = "16",
number = "3",
pages = "155-160",
url = "https://hdl.handle.net/21.15107/rcub_farfar_157"
}

Perović, M., Spasić, S., Bilbija, V., Bolits, Z.,& Jelić-Ivanović, Z.. (1997). Age- and sex-dependent values of triglycerides in adults in the region of Vojvodina, Yugoslavia. in Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 16(3), 155-160.
https://hdl.handle.net/21.15107/rcub_farfar_157

Perović M, Spasić S, Bilbija V, Bolits Z, Jelić-Ivanović Z. Age- and sex-dependent values of triglycerides in adults in the region of Vojvodina, Yugoslavia. in Jugoslovenska medicinska biohemija. 1997;16(3):155-160.
https://hdl.handle.net/21.15107/rcub_farfar_157 .

Perović, M, Spasić, S, Bilbija, V, Bolits, Z, Jelić-Ivanović, Zorana, "Age- and sex-dependent values of triglycerides in adults in the region of Vojvodina, Yugoslavia" in Jugoslovenska medicinska biohemija, 16, no. 3 (1997):155-160,
https://hdl.handle.net/21.15107/rcub_farfar_157 .

TY  - JOUR
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Stanković, B
AU  - Topić, Aleksandra
AU  - Spasić, S
PY  - 1996
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/143
AB  - The distribution of PI (protease inhibitor) phenotypes and PI M subtypes was studied in 200 patients with monoclonal gammopathies and 320 healthy blood donors by isoelectric focusing in thin-layer polyacrylamide gels, pH range 4-5. The distribution of PI phenotypes and gene frequencies in the patients differed significantly from the corresponding values found in the blood donors, as shown by the chi(2) test (chi(2) = 16.5, p = 0.02 and chi(2) = 17.6, p = 0.0014, respectively). A lower frequency of the M3 variant was observed in patients, both in homozygous (PI M3) and heterozygous forms (PI M1M3 and PI M2M3). No significant difference between PIz allele frequencies in patients and healthy controls was found.
PB  - Karger, Basel
T2  - Human Heredity
T1  - Low frequency of PIM3 gene in patients with monoclonal gammopathies
VL  - 46
IS  - 2
SP  - 115
EP  - 117
DO  - 10.1159/000154337
ER  - 

@article{
author = "Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Stanković, B and Topić, Aleksandra and Spasić, S",
year = "1996",
abstract = "The distribution of PI (protease inhibitor) phenotypes and PI M subtypes was studied in 200 patients with monoclonal gammopathies and 320 healthy blood donors by isoelectric focusing in thin-layer polyacrylamide gels, pH range 4-5. The distribution of PI phenotypes and gene frequencies in the patients differed significantly from the corresponding values found in the blood donors, as shown by the chi(2) test (chi(2) = 16.5, p = 0.02 and chi(2) = 17.6, p = 0.0014, respectively). A lower frequency of the M3 variant was observed in patients, both in homozygous (PI M3) and heterozygous forms (PI M1M3 and PI M2M3). No significant difference between PIz allele frequencies in patients and healthy controls was found.",
publisher = "Karger, Basel",
journal = "Human Heredity",
title = "Low frequency of PIM3 gene in patients with monoclonal gammopathies",
volume = "46",
number = "2",
pages = "115-117",
doi = "10.1159/000154337"
}

Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Stanković, B., Topić, A.,& Spasić, S.. (1996). Low frequency of PIM3 gene in patients with monoclonal gammopathies. in Human Heredity
Karger, Basel., 46(2), 115-117.
https://doi.org/10.1159/000154337

Jelić-Ivanović Z, Spasojević-Kalimanovska V, Stanković B, Topić A, Spasić S. Low frequency of PIM3 gene in patients with monoclonal gammopathies. in Human Heredity. 1996;46(2):115-117.
doi:10.1159/000154337 .

Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Stanković, B, Topić, Aleksandra, Spasić, S, "Low frequency of PIM3 gene in patients with monoclonal gammopathies" in Human Heredity, 46, no. 2 (1996):115-117,
https://doi.org/10.1159/000154337 . .

TY  - JOUR
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Topić, Aleksandra
AU  - Spasić, S
AU  - Petrović, V
PY  - 1994
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/113
AB  - The distribution of the alpha 1-antitrypsin (Pi) phenotypes and subtypes was investigated in a population sample of 1060 unrelated individuals from Serbia (Yugoslavia). The allele frequencies estimates were: Pi*M1: 0.702; Pi*M2: 0.183; Pi*M3: 0.088; Pi*Z: 0.013, Pi*S: 0.007; Pi*P: 0.004; Pi*F: 0.003. The observed phenotype frequencies differed very significantly from those expected assuming H.W. equilibrium (chi 2 = 49.51, p  lt  0.0005). The deviation from equilibrium involved the three Pi*M subtypes: an excess of Pi*M1, Pi*M2 and Pi*M3 homozygotes was found, with the corresponding decreased number of M1M2 and M1M3 heterozygotes. The possible significance of this finding is discussed.
T2  - Gene geography : a computerized bulletin on human gene frequencies
T1  - alpha-1-Antitrypsin (Pi) polymorphism in Serbia: deviation of Pi M subtype distribution from the Hardy-Weinberg equilibrium.
VL  - 8
IS  - 2
SP  - 129
EP  - 135
UR  - https://hdl.handle.net/21.15107/rcub_farfar_113
ER  - 

@article{
author = "Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Topić, Aleksandra and Spasić, S and Petrović, V",
year = "1994",
abstract = "The distribution of the alpha 1-antitrypsin (Pi) phenotypes and subtypes was investigated in a population sample of 1060 unrelated individuals from Serbia (Yugoslavia). The allele frequencies estimates were: Pi*M1: 0.702; Pi*M2: 0.183; Pi*M3: 0.088; Pi*Z: 0.013, Pi*S: 0.007; Pi*P: 0.004; Pi*F: 0.003. The observed phenotype frequencies differed very significantly from those expected assuming H.W. equilibrium (chi 2 = 49.51, p  lt  0.0005). The deviation from equilibrium involved the three Pi*M subtypes: an excess of Pi*M1, Pi*M2 and Pi*M3 homozygotes was found, with the corresponding decreased number of M1M2 and M1M3 heterozygotes. The possible significance of this finding is discussed.",
journal = "Gene geography : a computerized bulletin on human gene frequencies",
title = "alpha-1-Antitrypsin (Pi) polymorphism in Serbia: deviation of Pi M subtype distribution from the Hardy-Weinberg equilibrium.",
volume = "8",
number = "2",
pages = "129-135",
url = "https://hdl.handle.net/21.15107/rcub_farfar_113"
}

Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Topić, A., Spasić, S.,& Petrović, V.. (1994). alpha-1-Antitrypsin (Pi) polymorphism in Serbia: deviation of Pi M subtype distribution from the Hardy-Weinberg equilibrium.. in Gene geography : a computerized bulletin on human gene frequencies, 8(2), 129-135.
https://hdl.handle.net/21.15107/rcub_farfar_113

Jelić-Ivanović Z, Spasojević-Kalimanovska V, Topić A, Spasić S, Petrović V. alpha-1-Antitrypsin (Pi) polymorphism in Serbia: deviation of Pi M subtype distribution from the Hardy-Weinberg equilibrium.. in Gene geography : a computerized bulletin on human gene frequencies. 1994;8(2):129-135.
https://hdl.handle.net/21.15107/rcub_farfar_113 .

Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Topić, Aleksandra, Spasić, S, Petrović, V, "alpha-1-Antitrypsin (Pi) polymorphism in Serbia: deviation of Pi M subtype distribution from the Hardy-Weinberg equilibrium." in Gene geography : a computerized bulletin on human gene frequencies, 8, no. 2 (1994):129-135,
https://hdl.handle.net/21.15107/rcub_farfar_113 .

TY  - JOUR
AU  - Majkić-Singh, Nada
AU  - Bogavac, L
AU  - Kalimanovska, Vesna
AU  - Jelić, Z
AU  - Spasić, S
PY  - 1987
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/28
AB  - A new method for the determination of xanthine oxidase activity, based on the oxidation of 2, 2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) by use of uricase and peroxidase, is described. The absorbance increase of the oxidized form of ABTS, measured after 10 min at 410 nm is proportional to xanthine oxidase activity. The method is sensitive, precise (CV below 8.3%), and linear up to 20 U/l. The analytical recovery of the ABTS-method was quantitative. Comparison with the UV and colorimetric NBT-method gave good correlation (r ≥ 0.984). Reference values for serum xanthine oxidase activities determined with the new ABTS-method on 83 healthy persons are 0 to 1.20 U/l.
T2  - Clinica Chimica Acta
T1  - Spectrophotometric assay of xanthine oxidase with 2,2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) as chromogen
VL  - 162
IS  - 1
SP  - 29
EP  - 36
DO  - 10.1016/0009-8981(87)90229-4
ER  - 

@article{
author = "Majkić-Singh, Nada and Bogavac, L and Kalimanovska, Vesna and Jelić, Z and Spasić, S",
year = "1987",
abstract = "A new method for the determination of xanthine oxidase activity, based on the oxidation of 2, 2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) by use of uricase and peroxidase, is described. The absorbance increase of the oxidized form of ABTS, measured after 10 min at 410 nm is proportional to xanthine oxidase activity. The method is sensitive, precise (CV below 8.3%), and linear up to 20 U/l. The analytical recovery of the ABTS-method was quantitative. Comparison with the UV and colorimetric NBT-method gave good correlation (r ≥ 0.984). Reference values for serum xanthine oxidase activities determined with the new ABTS-method on 83 healthy persons are 0 to 1.20 U/l.",
journal = "Clinica Chimica Acta",
title = "Spectrophotometric assay of xanthine oxidase with 2,2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) as chromogen",
volume = "162",
number = "1",
pages = "29-36",
doi = "10.1016/0009-8981(87)90229-4"
}

Majkić-Singh, N., Bogavac, L., Kalimanovska, V., Jelić, Z.,& Spasić, S.. (1987). Spectrophotometric assay of xanthine oxidase with 2,2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) as chromogen. in Clinica Chimica Acta, 162(1), 29-36.
https://doi.org/10.1016/0009-8981(87)90229-4

Majkić-Singh N, Bogavac L, Kalimanovska V, Jelić Z, Spasić S. Spectrophotometric assay of xanthine oxidase with 2,2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) as chromogen. in Clinica Chimica Acta. 1987;162(1):29-36.
doi:10.1016/0009-8981(87)90229-4 .

Majkić-Singh, Nada, Bogavac, L, Kalimanovska, Vesna, Jelić, Z, Spasić, S, "Spectrophotometric assay of xanthine oxidase with 2,2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) as chromogen" in Clinica Chimica Acta, 162, no. 1 (1987):29-36,
https://doi.org/10.1016/0009-8981(87)90229-4 . .

TY  - JOUR
AU  - Jelić-Ivanović, Zorana
AU  - Majkić-Singh, Nada
AU  - Spasić, S
AU  - Todorović, P.
AU  - Stakić, D.Ž
PY  - 1983
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/10
T2  - Clinical Chemistry
T1  - Effect of analgesic and antirheumatic drugs on SMA II procedures
VL  - 29
IS  - 10
SP  - 1859
DO  - 10.1093/clinchem/29.10.1859
ER  - 

@article{
author = "Jelić-Ivanović, Zorana and Majkić-Singh, Nada and Spasić, S and Todorović, P. and Stakić, D.Ž",
year = "1983",
journal = "Clinical Chemistry",
title = "Effect of analgesic and antirheumatic drugs on SMA II procedures",
volume = "29",
number = "10",
pages = "1859",
doi = "10.1093/clinchem/29.10.1859"
}

Jelić-Ivanović, Z., Majkić-Singh, N., Spasić, S., Todorović, P.,& Stakić, D.Ž. (1983). Effect of analgesic and antirheumatic drugs on SMA II procedures. in Clinical Chemistry, 29(10), 1859.
https://doi.org/10.1093/clinchem/29.10.1859

Jelić-Ivanović Z, Majkić-Singh N, Spasić S, Todorović P, Stakić D. Effect of analgesic and antirheumatic drugs on SMA II procedures. in Clinical Chemistry. 1983;29(10):1859.
doi:10.1093/clinchem/29.10.1859 .

Jelić-Ivanović, Zorana, Majkić-Singh, Nada, Spasić, S, Todorović, P., Stakić, D.Ž, "Effect of analgesic and antirheumatic drugs on SMA II procedures" in Clinical Chemistry, 29, no. 10 (1983):1859,
https://doi.org/10.1093/clinchem/29.10.1859 . .