TY  - JOUR
AU  - Kotur-Stevuljević, Jelena
AU  - Memon, Lidija
AU  - Stefanović, Aleksandra
AU  - Spasić, Slavica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Jelić-Ivanović, Zorana
AU  - Zunić, Gordana
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/947
AB  - Objectives: In addition to many traditional risk factors for coronary artery disease (CAD) development, enhanced oxidative stress and inflammation are serious conditions that may also be classified as novel risk factors. In the present study, we assessed the relationship between several parameters of oxidative stress status [malonaldehyde (MDA), superoxide anion (O-2(center dot)-) and plasma and erythrocyte superoxide dismutase (SOD) activities] with high sensitivity C-reactive protein (hsCRP) and fibrinogen as inflammation markers. Design and methods: Oxidative stress status parameters, inflammation markers and lipid status parameters were measured in 385 subjects [188 coronary heart disease (CHD) patients with angiographically diagnosed coronary artery disease (CAD), 141 patients with occlusion > 50% in at least one major coronary artery (CAD+) and 47 patients with occlusion less than 50% (CAD-), and 197 CHD-free middle-aged subjects (the control group)]. Results: The plasma MDA concentration and the level of O-2(center dot)- in plasma were significantly higher in combination with significantly lower SOD activity in the CAD+ group vs. the control group. By using multiple stepwise regression analysis, fibrinogen and hsCRP showed independent correlation with MDA. Binary logistic regression analysis indicated that both MDA and O-2(center dot)- were significantly associated with CAD development and adjustment for inflammatory markers weakened this association in the case of MDA. Conclusions: The relationship between oxidative stress parameters and inflammatory species suggest their strong mutual involvement in atherosclerosis development that leads to CAD progression.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients
VL  - 40
IS  - 3-4
SP  - 181
EP  - 187
DO  - 10.1016/j.clinbiochem.2006.09.007
ER  - 

@article{
author = "Kotur-Stevuljević, Jelena and Memon, Lidija and Stefanović, Aleksandra and Spasić, Slavica and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kalimanovska-Oštrić, Dimitra and Jelić-Ivanović, Zorana and Zunić, Gordana",
year = "2007",
abstract = "Objectives: In addition to many traditional risk factors for coronary artery disease (CAD) development, enhanced oxidative stress and inflammation are serious conditions that may also be classified as novel risk factors. In the present study, we assessed the relationship between several parameters of oxidative stress status [malonaldehyde (MDA), superoxide anion (O-2(center dot)-) and plasma and erythrocyte superoxide dismutase (SOD) activities] with high sensitivity C-reactive protein (hsCRP) and fibrinogen as inflammation markers. Design and methods: Oxidative stress status parameters, inflammation markers and lipid status parameters were measured in 385 subjects [188 coronary heart disease (CHD) patients with angiographically diagnosed coronary artery disease (CAD), 141 patients with occlusion > 50% in at least one major coronary artery (CAD+) and 47 patients with occlusion less than 50% (CAD-), and 197 CHD-free middle-aged subjects (the control group)]. Results: The plasma MDA concentration and the level of O-2(center dot)- in plasma were significantly higher in combination with significantly lower SOD activity in the CAD+ group vs. the control group. By using multiple stepwise regression analysis, fibrinogen and hsCRP showed independent correlation with MDA. Binary logistic regression analysis indicated that both MDA and O-2(center dot)- were significantly associated with CAD development and adjustment for inflammatory markers weakened this association in the case of MDA. Conclusions: The relationship between oxidative stress parameters and inflammatory species suggest their strong mutual involvement in atherosclerosis development that leads to CAD progression.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients",
volume = "40",
number = "3-4",
pages = "181-187",
doi = "10.1016/j.clinbiochem.2006.09.007"
}

Kotur-Stevuljević, J., Memon, L., Stefanović, A., Spasić, S., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kalimanovska-Oštrić, D., Jelić-Ivanović, Z.,& Zunić, G.. (2007). Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 40(3-4), 181-187.
https://doi.org/10.1016/j.clinbiochem.2006.09.007

Kotur-Stevuljević J, Memon L, Stefanović A, Spasić S, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kalimanovska-Oštrić D, Jelić-Ivanović Z, Zunić G. Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients. in Clinical Biochemistry. 2007;40(3-4):181-187.
doi:10.1016/j.clinbiochem.2006.09.007 .

Kotur-Stevuljević, Jelena, Memon, Lidija, Stefanović, Aleksandra, Spasić, Slavica, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kalimanovska-Oštrić, Dimitra, Jelić-Ivanović, Zorana, Zunić, Gordana, "Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients" in Clinical Biochemistry, 40, no. 3-4 (2007):181-187,
https://doi.org/10.1016/j.clinbiochem.2006.09.007 . .