TY  - CONF
AU  - Manić, Luka
AU  - Đorđević, Vladimir
AU  - Grubor, Nikica
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
AU  - Uysal-Onganer, Pinar
AU  - Mortoglou, Maria
AU  - Wallace, David
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5512
AB  - Istraživanje u oblasti karcinoma pankreasa i zagađivača iz životne sredine sve je intenzivnije. Za neke od ovih zagađivača pretpostavlja se da su povezani sa nastankom ili progresijom karcinoma pankreasa. Nijedna meta-analiza o povezanosti navedenog nije sprovedena, dok bi rezultati iste mogli pomoći u tumačenju dostupnih podataka i usmeravanju budućeg istraživanja. ...
AB  - There is a rise in research on the connection between pancreatic cancer and environmental pollutants. Some of these pollutants are assumed to be associated with the onset or progression of pancreatic cancer. No meta-analyses summarizing the association between these two have been conducted yet, while the results of such an analysis could help interpret current and guide future research.  ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?
T1  - A meta-analysis excerpt: Is exposure to environmental pollutants associated with pancreatic cancer?
SP  - 143
EP  - 146
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5512
ER  - 

@conference{
author = "Manić, Luka and Đorđević, Vladimir and Grubor, Nikica and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela and Uysal-Onganer, Pinar and Mortoglou, Maria and Wallace, David and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Istraživanje u oblasti karcinoma pankreasa i zagađivača iz životne sredine sve je intenzivnije. Za neke od ovih zagađivača pretpostavlja se da su povezani sa nastankom ili progresijom karcinoma pankreasa. Nijedna meta-analiza o povezanosti navedenog nije sprovedena, dok bi rezultati iste mogli pomoći u tumačenju dostupnih podataka i usmeravanju budućeg istraživanja. ..., There is a rise in research on the connection between pancreatic cancer and environmental pollutants. Some of these pollutants are assumed to be associated with the onset or progression of pancreatic cancer. No meta-analyses summarizing the association between these two have been conducted yet, while the results of such an analysis could help interpret current and guide future research.  ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?, A meta-analysis excerpt: Is exposure to environmental pollutants associated with pancreatic cancer?",
pages = "143-146",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5512"
}

Manić, L., Đorđević, V., Grubor, N., Bulat, Z., Antonijević, B., Đukić-Ćosić, D., Uysal-Onganer, P., Mortoglou, M., Wallace, D.,& Buha-Đorđević, A.. (2023). Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 143-146.
https://hdl.handle.net/21.15107/rcub_farfar_5512

Manić L, Đorđević V, Grubor N, Bulat Z, Antonijević B, Đukić-Ćosić D, Uysal-Onganer P, Mortoglou M, Wallace D, Buha-Đorđević A. Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:143-146.
https://hdl.handle.net/21.15107/rcub_farfar_5512 .

Manić, Luka, Đorđević, Vladimir, Grubor, Nikica, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, Uysal-Onganer, Pinar, Mortoglou, Maria, Wallace, David, Buha-Đorđević, Aleksandra, "Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):143-146,
https://hdl.handle.net/21.15107/rcub_farfar_5512 .

TY  - CONF
AU  - Uysal-Onganer, Pinar
AU  - Mortoglou, Maria
AU  - Wallace, David
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5500
AB  - Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy, with a 5-year overall survival of less than 8%. Early detection is particularly difficult due to the lack of symptoms even in advanced stages. microRNAs (miRs/miRNAs) are small (~18–24 nucleotides), endogenous, non-coding RNAs, which are involved in the pathogenesis of several malignancies including PDAC. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Role of cadmium and nickel on selected microrna expression in pancreatic ductal adenocarcinoma
SP  - 10
EP  - 10
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5500
ER  - 

@conference{
author = "Uysal-Onganer, Pinar and Mortoglou, Maria and Wallace, David and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy, with a 5-year overall survival of less than 8%. Early detection is particularly difficult due to the lack of symptoms even in advanced stages. microRNAs (miRs/miRNAs) are small (~18–24 nucleotides), endogenous, non-coding RNAs, which are involved in the pathogenesis of several malignancies including PDAC. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Role of cadmium and nickel on selected microrna expression in pancreatic ductal adenocarcinoma",
pages = "10-10",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5500"
}

Uysal-Onganer, P., Mortoglou, M., Wallace, D.,& Buha-Đorđević, A.. (2023). Role of cadmium and nickel on selected microrna expression in pancreatic ductal adenocarcinoma. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 10-10.
https://hdl.handle.net/21.15107/rcub_farfar_5500

Uysal-Onganer P, Mortoglou M, Wallace D, Buha-Đorđević A. Role of cadmium and nickel on selected microrna expression in pancreatic ductal adenocarcinoma. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:10-10.
https://hdl.handle.net/21.15107/rcub_farfar_5500 .

Uysal-Onganer, Pinar, Mortoglou, Maria, Wallace, David, Buha-Đorđević, Aleksandra, "Role of cadmium and nickel on selected microrna expression in pancreatic ductal adenocarcinoma" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):10-10,
https://hdl.handle.net/21.15107/rcub_farfar_5500 .

TY  - JOUR
AU  - Mortoglou, Maria
AU  - Manić, Luka
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Đorđević, Vladimir
AU  - Manis, Katherine
AU  - York, Lauren
AU  - Valle, Elizabeth
AU  - Wallace, David
AU  - Uysal-Onganer, Pinar
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4352
AB  - Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types with a limited overall survival rate due to the asymptomatic progression of symptoms in metastatic stages of the malignancy and the lack of an early reliable diagnostic biomarker. MicroRNAs (miRs/miRNAs) are small (~18–24 nucleotides), endogenous, non-coding RNAs, which are closely linked to the development of numerous malignancies comprising PDAC. Recent studies have described the role of environmental pollutants such as nickel (Ni) in PDAC, but the mechanisms of Ni-mediated toxicity in cancer are still not completely understood. Specifically, Ni has been found to alter the expression and function of miRs in several malignancies, leading to changes in target gene expression. In this study, we found that levels of Ni were significantly higher in cancerous tissue, thus implicating Ni in pancreatic carcinogenesis. Hence, in vitro studies followed by using both normal and pancreatic tumor cell lines and increasing Ni concentration increased lethality. Comparing LC50 values, Ni-acetate groups demonstrated lower values needed than in NiCl2 groups, suggesting greater Ni-acetate. Panc-10.05 cell line appeared the most sensitive to Ni compounds. Exposure to Ni-acetate resulted in an increased phospho-AKT, and decreased FOXO1 expression in Panc-10.05 cells, while NiCl2 also increased PTEN expression in Panc-10.05 cells. Specifically, following NiCl2 exposure to PDAC cells, the expression levels of miR-221 and miR-155 were significantly upregulated, while the expression levels of miR-126 were significantly decreased. Hence, our study has suggested pilot insights to indicate that the environmental pollutant Ni plays an important role in the progression of PDAC by promoting an association between miRs and Ni exposure during PDAC pathogenesis.
PB  - MDPI
T2  - Toxics
T1  - Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs
VL  - 10
IS  - 3
DO  - 10.3390/toxics10030148
ER  - 

@article{
author = "Mortoglou, Maria and Manić, Luka and Buha-Đorđević, Aleksandra and Bulat, Zorica and Đorđević, Vladimir and Manis, Katherine and York, Lauren and Valle, Elizabeth and Wallace, David and Uysal-Onganer, Pinar",
year = "2022",
abstract = "Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types with a limited overall survival rate due to the asymptomatic progression of symptoms in metastatic stages of the malignancy and the lack of an early reliable diagnostic biomarker. MicroRNAs (miRs/miRNAs) are small (~18–24 nucleotides), endogenous, non-coding RNAs, which are closely linked to the development of numerous malignancies comprising PDAC. Recent studies have described the role of environmental pollutants such as nickel (Ni) in PDAC, but the mechanisms of Ni-mediated toxicity in cancer are still not completely understood. Specifically, Ni has been found to alter the expression and function of miRs in several malignancies, leading to changes in target gene expression. In this study, we found that levels of Ni were significantly higher in cancerous tissue, thus implicating Ni in pancreatic carcinogenesis. Hence, in vitro studies followed by using both normal and pancreatic tumor cell lines and increasing Ni concentration increased lethality. Comparing LC50 values, Ni-acetate groups demonstrated lower values needed than in NiCl2 groups, suggesting greater Ni-acetate. Panc-10.05 cell line appeared the most sensitive to Ni compounds. Exposure to Ni-acetate resulted in an increased phospho-AKT, and decreased FOXO1 expression in Panc-10.05 cells, while NiCl2 also increased PTEN expression in Panc-10.05 cells. Specifically, following NiCl2 exposure to PDAC cells, the expression levels of miR-221 and miR-155 were significantly upregulated, while the expression levels of miR-126 were significantly decreased. Hence, our study has suggested pilot insights to indicate that the environmental pollutant Ni plays an important role in the progression of PDAC by promoting an association between miRs and Ni exposure during PDAC pathogenesis.",
publisher = "MDPI",
journal = "Toxics",
title = "Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs",
volume = "10",
number = "3",
doi = "10.3390/toxics10030148"
}

Mortoglou, M., Manić, L., Buha-Đorđević, A., Bulat, Z., Đorđević, V., Manis, K., York, L., Valle, E., Wallace, D.,& Uysal-Onganer, P.. (2022). Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs. in Toxics
MDPI., 10(3).
https://doi.org/10.3390/toxics10030148

Mortoglou M, Manić L, Buha-Đorđević A, Bulat Z, Đorđević V, Manis K, York L, Valle E, Wallace D, Uysal-Onganer P. Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs. in Toxics. 2022;10(3).
doi:10.3390/toxics10030148 .

Mortoglou, Maria, Manić, Luka, Buha-Đorđević, Aleksandra, Bulat, Zorica, Đorđević, Vladimir, Manis, Katherine, York, Lauren, Valle, Elizabeth, Wallace, David, Uysal-Onganer, Pinar, "Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs" in Toxics, 10, no. 3 (2022),
https://doi.org/10.3390/toxics10030148 . .