@conference{
author = "Kuzmanović Nedeljković, Snežana and Stević, Tatjana and Bigović, Dubravka and Šavikin, Katarina and Filipić, Brankica",
year = "2022",
abstract = "BACKGROUND
COVID-19 pandemic brought a burden to the health care system including a higher rate of patients admitted to the intensive care unit (ICU). Mechanical ventilation, needed in COVID-19 patients admitted to ICU, increases the risk of developing multidrug-resistant (MDR) Acinetobacter baumannii superinfection, which may cause major problems in antibiotic treatment.
OBJECTIVES
The aim of this research was to examine the susceptibility of A. baumannii isolates recovered from COVID-19 patients
to antibiotics usually used as treatment options, and to Oregano essential oil (EO) as naturally derived compound.
METHODS
The 54 A. baumannii isolates were recovered from COVID-19 patients admitted to ICU, during period from December
2020 to February 2021. Biofilm formation ability, as the factor that contributes to bacterial resistance, was examined. Minimum inhibitory concentrations (MICs) were determined for meropenem, imipenem, colistin, gentamicin, tobramycin and levofloxacin. In addition, all 54 isolates of A. baumanii were tested for susceptibility to Oregano EO.
RESULTS
Results obtained in this study revealed a significant MDR profile of tested A. baumannii isolates. Even 74% (40/54) were strong biofilm producers. A. baumannii isolates were resistant to all tested antibiotics, except to colistin, leaving colistin as the only treatment option. On the other hand, MIC results obtained for Oregano EO were extremely promising: 0.279 mg/mL for all tested isolates. The obtained results emphasize a potentially new treatment approach to infections caused by MDR A. baumannii, using natural products such as EOs.",
publisher = "Federation of European Microbiological Societies, Serbian Society for Microbiology",
journal = "FEMS Conference on Microbiology in association with Serbian Society of Microbiology, 30 June - 2 July 2022, Serbia - electronic abstract book",
title = "Oregano essential oil sensitivity of multiresistant Acinetobacter baumannii strains isolated from COVID-19 patients",
pages = "272-272",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5119"
}