TY  - CONF
AU  - Jevtić, G. M.
AU  - Hrgić, S. P.
AU  - Vučetić, V. S.
AU  - Glišić, V.
AU  - Popović, B.
AU  - Vezmar-Kovačević, Sandra
AU  - Ćulafić, Milica
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1864
PB  - Springer, Dordrecht
C3  - International Journal of Clinical Pharmacy
T1  - What do patients know about their medication therapy at hospital discharge?
VL  - 35
IS  - 5
SP  - 866
EP  - 867
DO  - 10.1007/s11096-013-9801-0
ER  - 

@conference{
author = "Jevtić, G. M. and Hrgić, S. P. and Vučetić, V. S. and Glišić, V. and Popović, B. and Vezmar-Kovačević, Sandra and Ćulafić, Milica",
year = "2013",
publisher = "Springer, Dordrecht",
journal = "International Journal of Clinical Pharmacy",
title = "What do patients know about their medication therapy at hospital discharge?",
volume = "35",
number = "5",
pages = "866-867",
doi = "10.1007/s11096-013-9801-0"
}

Jevtić, G. M., Hrgić, S. P., Vučetić, V. S., Glišić, V., Popović, B., Vezmar-Kovačević, S.,& Ćulafić, M.. (2013). What do patients know about their medication therapy at hospital discharge?. in International Journal of Clinical Pharmacy
Springer, Dordrecht., 35(5), 866-867.
https://doi.org/10.1007/s11096-013-9801-0

Jevtić GM, Hrgić SP, Vučetić VS, Glišić V, Popović B, Vezmar-Kovačević S, Ćulafić M. What do patients know about their medication therapy at hospital discharge?. in International Journal of Clinical Pharmacy. 2013;35(5):866-867.
doi:10.1007/s11096-013-9801-0 .

Jevtić, G. M., Hrgić, S. P., Vučetić, V. S., Glišić, V., Popović, B., Vezmar-Kovačević, Sandra, Ćulafić, Milica, "What do patients know about their medication therapy at hospital discharge?" in International Journal of Clinical Pharmacy, 35, no. 5 (2013):866-867,
https://doi.org/10.1007/s11096-013-9801-0 . .

TY  - JOUR
AU  - Micov, Ana
AU  - Tomić, Maja
AU  - Popović, B.
AU  - Stepanović-Petrović, Radica
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1338
AB  - BACKGROUND AND PURPOSE Levetiracetam, a novel antiepileptic drug, has recently been shown to have antinociceptive effects in various animal models of pain. The purpose of this study was to investigate the antihyperalgesic effect of levetiracetam and its mechanism of action, by examining the involvement of GABAergic, opioidergic, 5-hydroxytryptaminergic (5-HTergic) and adrenergic systems in its effect, in a rat model of inflammatory pain. EXPERIMENTAL APPROACH Rats were intraplantarly injected with the pro-inflammatory compound carrageenan. A paw pressure test was used to determine: (i) the effect of levetiracetam on carrageenan-induced hyperalgesia; and (ii) the effects of bicuculline (selective GABA(A) receptor antagonist), naloxone (non-selective opioid receptor antagonist), methysergide (non-selective 5-HT receptor antagonist) and yohimbine (selective alpha(2)-adrenoceptor antagonist) on the antihyperalgesic action of levetiracetam. RESULTS Levetiracetam (10-200 mg center dot kg-1; p.o.) significantly reduced, in a dose-dependent manner, the inflammatory hyperalgesia induced by carrageenan. The antihyperalgesic effect of levetiracetam was significantly decreased after administration of bicuculline (0.5-2 mg center dot kg-1; i.p.), naloxone (1-3 mg center dot kg-1; i.p.), methysergide (0.25-1 mg center dot kg-1; i.p.) and yohimbine (1-3 mg center dot kg-1; i.p.). CONCLUSIONS AND IMPLICATIONS These results show that levetiracetam produced antihyperalgesia which is at least in part mediated by GABA(A), opioid, 5-HT and alpha(2)-adrenergic receptors, in an inflammatory model of pain. The efficacy of levetiracetam in this animal model of inflammatory pain suggests that it could be a potentially important agent for treating inflammatory pain conditions in humans.
PB  - Wiley-Blackwell, Malden
T2  - British Journal of Pharmacology
T1  - The antihyperalgesic effect of levetiracetam in an inflammatory model of pain in rats: mechanism of action
VL  - 161
IS  - 2
SP  - 384
EP  - 392
DO  - 10.1111/j.1476-5381.2010.00877.x
ER  - 

@article{
author = "Micov, Ana and Tomić, Maja and Popović, B. and Stepanović-Petrović, Radica",
year = "2010",
abstract = "BACKGROUND AND PURPOSE Levetiracetam, a novel antiepileptic drug, has recently been shown to have antinociceptive effects in various animal models of pain. The purpose of this study was to investigate the antihyperalgesic effect of levetiracetam and its mechanism of action, by examining the involvement of GABAergic, opioidergic, 5-hydroxytryptaminergic (5-HTergic) and adrenergic systems in its effect, in a rat model of inflammatory pain. EXPERIMENTAL APPROACH Rats were intraplantarly injected with the pro-inflammatory compound carrageenan. A paw pressure test was used to determine: (i) the effect of levetiracetam on carrageenan-induced hyperalgesia; and (ii) the effects of bicuculline (selective GABA(A) receptor antagonist), naloxone (non-selective opioid receptor antagonist), methysergide (non-selective 5-HT receptor antagonist) and yohimbine (selective alpha(2)-adrenoceptor antagonist) on the antihyperalgesic action of levetiracetam. RESULTS Levetiracetam (10-200 mg center dot kg-1; p.o.) significantly reduced, in a dose-dependent manner, the inflammatory hyperalgesia induced by carrageenan. The antihyperalgesic effect of levetiracetam was significantly decreased after administration of bicuculline (0.5-2 mg center dot kg-1; i.p.), naloxone (1-3 mg center dot kg-1; i.p.), methysergide (0.25-1 mg center dot kg-1; i.p.) and yohimbine (1-3 mg center dot kg-1; i.p.). CONCLUSIONS AND IMPLICATIONS These results show that levetiracetam produced antihyperalgesia which is at least in part mediated by GABA(A), opioid, 5-HT and alpha(2)-adrenergic receptors, in an inflammatory model of pain. The efficacy of levetiracetam in this animal model of inflammatory pain suggests that it could be a potentially important agent for treating inflammatory pain conditions in humans.",
publisher = "Wiley-Blackwell, Malden",
journal = "British Journal of Pharmacology",
title = "The antihyperalgesic effect of levetiracetam in an inflammatory model of pain in rats: mechanism of action",
volume = "161",
number = "2",
pages = "384-392",
doi = "10.1111/j.1476-5381.2010.00877.x"
}

Micov, A., Tomić, M., Popović, B.,& Stepanović-Petrović, R.. (2010). The antihyperalgesic effect of levetiracetam in an inflammatory model of pain in rats: mechanism of action. in British Journal of Pharmacology
Wiley-Blackwell, Malden., 161(2), 384-392.
https://doi.org/10.1111/j.1476-5381.2010.00877.x

Micov A, Tomić M, Popović B, Stepanović-Petrović R. The antihyperalgesic effect of levetiracetam in an inflammatory model of pain in rats: mechanism of action. in British Journal of Pharmacology. 2010;161(2):384-392.
doi:10.1111/j.1476-5381.2010.00877.x .

Micov, Ana, Tomić, Maja, Popović, B., Stepanović-Petrović, Radica, "The antihyperalgesic effect of levetiracetam in an inflammatory model of pain in rats: mechanism of action" in British Journal of Pharmacology, 161, no. 2 (2010):384-392,
https://doi.org/10.1111/j.1476-5381.2010.00877.x . .