TY  - JOUR
AU  - Mirjanić-Azarić, Bosa
AU  - Avram, Sanja
AU  - Stojaković-Jelisavac, Tanja
AU  - Stojanović, Darja
AU  - Petković, Mira
AU  - Bogavac-Stanojević, Nataša
AU  - Ignjatović, Svetlana
AU  - Stojanov, Marina
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3008
AB  - Background: The aim of this study was to determine the reference values for thyrotropin (TSH), thyroid hormones (total and free thyroxine, T4 and fT4; total and free triiodothyronine, T3 and fT3), thyroglobulin (Tg) and thyroid antibodies (thyroid peroxidase, TPOAb and thyroglobulin antibody, TgAb) in the population of the Republic of Srpska. Methods: A total of 250 euthyroid subjects were enrolled in this study. A direct method for choosing reference subjects was used to establish reference intervals. The hormones and thyroid antibodies were measured by an electrochemiluminescence immunoassay method (ECLIA, Roche Diagnostics, Mannheim, Germany). We calculated the re f erence intervals by MedCalc, version 12.1.4.0 (MedCalc software, Belgium) as recommended by the IFCC (CLSI C28-A3). Results: Using guidelines recommended by the National Academy of Clinical Biochemistry (NACB) and based on standard statistical approaches, the reference intervals derived for TSH, fT4, T4, fT3, T3 were 0.75-5.32 mIU/L, 12.29-20.03 pmol/L, 73.49-126,30 nmol/L, 4.11-6.32 pmol/L, 1.15-2.32 nmol/L and for Tg, TPOAb, TgAb were 3.63-26.00 mu g/L,  lt  18.02 mIU/L,  lt  98.00 mIU/L, respe ctively. We found a significant difference (p lt  0.05) in TSH and fT3 values between different age groups as well as in T4, fT4 and fT3 values between ge nder groups. Conclusions: The established reference values for the population of the Republic of Srpska were significantly different from the values recommended by the manufacturer of reagents (Roche Diagnostics). Our results showed that a laboratory needs to establish its own reference values in order to set up a proper diagnosis, as well as to treat patients successfully.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Direct Estimation of Reference Intervals for Thyroid Parameters in the Republic of Srpska
VL  - 36
IS  - 2
SP  - 137
EP  - 144
DO  - 10.1515/jomb-2017-0008
ER  - 

@article{
author = "Mirjanić-Azarić, Bosa and Avram, Sanja and Stojaković-Jelisavac, Tanja and Stojanović, Darja and Petković, Mira and Bogavac-Stanojević, Nataša and Ignjatović, Svetlana and Stojanov, Marina",
year = "2017",
abstract = "Background: The aim of this study was to determine the reference values for thyrotropin (TSH), thyroid hormones (total and free thyroxine, T4 and fT4; total and free triiodothyronine, T3 and fT3), thyroglobulin (Tg) and thyroid antibodies (thyroid peroxidase, TPOAb and thyroglobulin antibody, TgAb) in the population of the Republic of Srpska. Methods: A total of 250 euthyroid subjects were enrolled in this study. A direct method for choosing reference subjects was used to establish reference intervals. The hormones and thyroid antibodies were measured by an electrochemiluminescence immunoassay method (ECLIA, Roche Diagnostics, Mannheim, Germany). We calculated the re f erence intervals by MedCalc, version 12.1.4.0 (MedCalc software, Belgium) as recommended by the IFCC (CLSI C28-A3). Results: Using guidelines recommended by the National Academy of Clinical Biochemistry (NACB) and based on standard statistical approaches, the reference intervals derived for TSH, fT4, T4, fT3, T3 were 0.75-5.32 mIU/L, 12.29-20.03 pmol/L, 73.49-126,30 nmol/L, 4.11-6.32 pmol/L, 1.15-2.32 nmol/L and for Tg, TPOAb, TgAb were 3.63-26.00 mu g/L,  lt  18.02 mIU/L,  lt  98.00 mIU/L, respe ctively. We found a significant difference (p lt  0.05) in TSH and fT3 values between different age groups as well as in T4, fT4 and fT3 values between ge nder groups. Conclusions: The established reference values for the population of the Republic of Srpska were significantly different from the values recommended by the manufacturer of reagents (Roche Diagnostics). Our results showed that a laboratory needs to establish its own reference values in order to set up a proper diagnosis, as well as to treat patients successfully.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Direct Estimation of Reference Intervals for Thyroid Parameters in the Republic of Srpska",
volume = "36",
number = "2",
pages = "137-144",
doi = "10.1515/jomb-2017-0008"
}

Mirjanić-Azarić, B., Avram, S., Stojaković-Jelisavac, T., Stojanović, D., Petković, M., Bogavac-Stanojević, N., Ignjatović, S.,& Stojanov, M.. (2017). Direct Estimation of Reference Intervals for Thyroid Parameters in the Republic of Srpska. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 36(2), 137-144.
https://doi.org/10.1515/jomb-2017-0008

Mirjanić-Azarić B, Avram S, Stojaković-Jelisavac T, Stojanović D, Petković M, Bogavac-Stanojević N, Ignjatović S, Stojanov M. Direct Estimation of Reference Intervals for Thyroid Parameters in the Republic of Srpska. in Journal of Medical Biochemistry. 2017;36(2):137-144.
doi:10.1515/jomb-2017-0008 .

Mirjanić-Azarić, Bosa, Avram, Sanja, Stojaković-Jelisavac, Tanja, Stojanović, Darja, Petković, Mira, Bogavac-Stanojević, Nataša, Ignjatović, Svetlana, Stojanov, Marina, "Direct Estimation of Reference Intervals for Thyroid Parameters in the Republic of Srpska" in Journal of Medical Biochemistry, 36, no. 2 (2017):137-144,
https://doi.org/10.1515/jomb-2017-0008 . .